EP1872120A4 - Free thyroxine and free triiodothyronine analysis by mass spectrometry - Google Patents

Free thyroxine and free triiodothyronine analysis by mass spectrometry

Info

Publication number
EP1872120A4
EP1872120A4 EP05851243A EP05851243A EP1872120A4 EP 1872120 A4 EP1872120 A4 EP 1872120A4 EP 05851243 A EP05851243 A EP 05851243A EP 05851243 A EP05851243 A EP 05851243A EP 1872120 A4 EP1872120 A4 EP 1872120A4
Authority
EP
European Patent Office
Prior art keywords
free
analysis
mass spectrometry
triiodothyronine
thyroxine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05851243A
Other languages
German (de)
French (fr)
Other versions
EP1872120B1 (en
EP1872120A2 (en
Inventor
Steven J Soldin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of EP1872120A2 publication Critical patent/EP1872120A2/en
Publication of EP1872120A4 publication Critical patent/EP1872120A4/en
Application granted granted Critical
Publication of EP1872120B1 publication Critical patent/EP1872120B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP05851243A 2005-03-31 2005-10-20 Free thyroxine and free triiodothyronine analysis by mass spectrometry Active EP1872120B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66671205P 2005-03-31 2005-03-31
PCT/US2005/038232 WO2006107339A2 (en) 2005-03-31 2005-10-20 Free thyroxine and free triiodothyronine analysis by mass spectrometry

Publications (3)

Publication Number Publication Date
EP1872120A2 EP1872120A2 (en) 2008-01-02
EP1872120A4 true EP1872120A4 (en) 2009-04-29
EP1872120B1 EP1872120B1 (en) 2012-12-05

Family

ID=37073885

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05851243A Active EP1872120B1 (en) 2005-03-31 2005-10-20 Free thyroxine and free triiodothyronine analysis by mass spectrometry

Country Status (5)

Country Link
US (1) US8227259B2 (en)
EP (1) EP1872120B1 (en)
JP (1) JP2008534955A (en)
CA (1) CA2608796C (en)
WO (1) WO2006107339A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
WO2007090081A2 (en) * 2006-01-27 2007-08-09 The Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations Analysis of mycophenolic acid in saliva using liquid chromatography tandem mass spectrometry
WO2007139956A2 (en) * 2006-05-26 2007-12-06 Laboratory Corporation Of America Holdings Methods and systems for the quantitative analysis of biomarkers
US20080102535A1 (en) * 2006-11-01 2008-05-01 Chace Donald H Measuring thyroxine levels from dried blood samples using mass spectrometry
US20090134325A1 (en) * 2007-11-27 2009-05-28 Goldman Mildred M Methods for detecting estradiol by mass spectrometry
US7972868B2 (en) * 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
US8030084B2 (en) * 2007-12-06 2011-10-04 Quest Diagnostics Investments Incorporated Thyroglobulin quantitation by mass spectrometry
US8916385B2 (en) 2007-12-13 2014-12-23 Quest Diagnostics Investments, Inc. Methods for detecting estrone by mass spectrometry
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
CA2783708C (en) 2009-12-11 2018-09-18 Quest Diagnostics Investments Incorporated Mass spectrometry of steroidal compounds in multiplex samples
JP6113504B2 (en) 2009-12-11 2017-04-12 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド Determination of non-derivatized non-metabolized vitamin D by mass spectrometry
US8669519B2 (en) * 2011-12-05 2014-03-11 Quest Diagnostics Investments, Inc. Methods for detecting reverse triiodothyronine by mass spectrometry
US9012394B2 (en) 2012-09-20 2015-04-21 Quest Diagnostics Investments, Inc. Thyroglobulin quantitation by mass spectroscopy
WO2016019037A1 (en) * 2014-07-29 2016-02-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Free hormone and hormone metabolite workup and analysis by mass spectrometry
WO2016042627A1 (en) * 2014-09-17 2016-03-24 株式会社島津製作所 Mass spectrometer
EP4328739A3 (en) 2017-07-07 2024-04-03 nChain Licensing AG Control flow in blockchain scripts
CN111398490A (en) * 2020-03-04 2020-07-10 上海睿质科技有限公司 Kit for detecting free triiodothyronine and free thyroxine by mass spectrometry
CN113281526B (en) * 2021-03-18 2022-04-08 杭州微策生物技术股份有限公司 Sample pad treatment reagent of free thyroxine detection reagent strip
CN116298023A (en) * 2021-04-13 2023-06-23 杭州凯莱谱精准医疗检测技术有限公司 Method for simultaneously measuring free thyroid hormones T3, rT3, T4 and cortisol in saliva
CN116626191A (en) * 2022-03-22 2023-08-22 合肥歆智医疗器械有限公司 Ultrafiltration-liquid chromatography tandem mass spectrometry for detecting free testosterone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046772A1 (en) * 2000-12-08 2002-06-13 Women's And Children's Hospital Detection of compounds such as thyroxine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4023398A (en) 1975-03-03 1977-05-17 John Barry French Apparatus for analyzing trace components
US4328420A (en) 1980-07-28 1982-05-04 French John B Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system
US4741897A (en) 1986-07-08 1988-05-03 Baxter Travenol Thyroxine analogs and reagents for thyroid hormone assays
CA1307859C (en) 1988-12-12 1992-09-22 Donald James Douglas Mass spectrometer and method with improved ion transmission
US5179278A (en) 1991-08-23 1993-01-12 Mds Health Group Limited Multipole inlet system for ion traps
US5248875A (en) 1992-04-24 1993-09-28 Mds Health Group Limited Method for increased resolution in tandem mass spectrometry
US5412208A (en) 1994-01-13 1995-05-02 Mds Health Group Limited Ion spray with intersecting flow
WO1997007530A1 (en) 1995-08-11 1997-02-27 Mds Health Group Limited Spectrometer with axial field
US6153440A (en) * 1998-09-23 2000-11-28 The Regents Of The University Of California Simultaneous measurement of free triiodothyronine and free thyroxine by equilibrium dialysis and immunoassay
AU2001264650A1 (en) 2000-05-18 2001-11-26 Mayo Foundation For Medical Education And Research Adrenal dysfunction
EP1644743B1 (en) 2003-04-14 2014-11-12 Georgetown University Thyroid hormone analysis by mass spectrometry

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046772A1 (en) * 2000-12-08 2002-06-13 Women's And Children's Hospital Detection of compounds such as thyroxine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GU JIANGHONG ET AL: "Simultaneous quantification of free triiodothyronine and free thyroxine by isotope dilution tandem mass spectrometry", December 2007, CLINICAL BIOCHEMISTRY, VOL. 40, NR. 18, PAGE(S) 1386-1391, ISSN: 0009-9120, XP002518784 *
See also references of WO2006107339A2 *
SOUKHOVA N ET AL: "ISOTOPE DILUTION TANDEM MASS SPECTROMETRIC METHOD FOR T4/T3", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 343, no. 1/02, 1 January 2004 (2004-01-01), pages 185 - 190, XP001181882, ISSN: 0009-8981 *

Also Published As

Publication number Publication date
WO2006107339A3 (en) 2007-11-01
EP1872120B1 (en) 2012-12-05
US8227259B2 (en) 2012-07-24
US20060223188A1 (en) 2006-10-05
EP1872120A2 (en) 2008-01-02
CA2608796C (en) 2013-09-03
WO2006107339A2 (en) 2006-10-12
JP2008534955A (en) 2008-08-28
CA2608796A1 (en) 2006-10-12

Similar Documents

Publication Publication Date Title
EP1872120A4 (en) Free thyroxine and free triiodothyronine analysis by mass spectrometry
GB2429110B (en) Mass spectrometer
GB2423866B (en) Mass spectrometer
GB2432255B (en) Mass spectrometer
GB2423864B (en) Mass spectrometer
GB0624481D0 (en) Mass Spectrometer
GB0621787D0 (en) Mass spectrometer
GB0524042D0 (en) Mass spectrometer
GB0523812D0 (en) Mass spectrometer
GB0526043D0 (en) Mass spectrometer
GB2425650B (en) Mass spectrometer
GB0511333D0 (en) Mass spectrometer
EP1933134A4 (en) Mass analyzer
GB2428870B (en) Mass spectrometric mixture analysis
GB0623376D0 (en) Mass spectrometer
GB2423820B (en) Mass spectrometer
GB0623377D0 (en) Mass spectrometer
GB0713286D0 (en) Mass spectrometer
HK1111072A1 (en) Fingerprint analysis using mass spectrometry
GB0725273D0 (en) Mass spectrometer
GB0516271D0 (en) Fingerprint analysis using mass spectrometry
GB0503620D0 (en) Mass spectrometer
GB0500842D0 (en) Mass spectrometer
GB0504569D0 (en) Mass spectrometer
GB0513019D0 (en) Mass spectrometer

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20071017

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK YU

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20090401

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/78 20060101AFI20090323BHEP

17Q First examination report despatched

Effective date: 20090803

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602005037345

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: G01N0033000000

Ipc: G01N0033680000

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/78 20060101ALI20120308BHEP

Ipc: G01N 33/68 20060101AFI20120308BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 587535

Country of ref document: AT

Kind code of ref document: T

Effective date: 20121215

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602005037345

Country of ref document: DE

Effective date: 20130131

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 587535

Country of ref document: AT

Kind code of ref document: T

Effective date: 20121205

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130316

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20121205

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130306

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130405

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130305

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130405

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

26N No opposition filed

Effective date: 20130906

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602005037345

Country of ref document: DE

Effective date: 20130906

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131031

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131020

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121205

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20051020

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131020

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 11

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 12

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 13

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 14

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20230831

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20230911

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20230822

Year of fee payment: 19