EP1851227A4 - An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one - Google Patents

An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one

Info

Publication number
EP1851227A4
EP1851227A4 EP06735630A EP06735630A EP1851227A4 EP 1851227 A4 EP1851227 A4 EP 1851227A4 EP 06735630 A EP06735630 A EP 06735630A EP 06735630 A EP06735630 A EP 06735630A EP 1851227 A4 EP1851227 A4 EP 1851227A4
Authority
EP
European Patent Office
Prior art keywords
tetrahydropyrrolo
dihydrobenzofuran
quinolin
efficient
large scale
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06735630A
Other languages
German (de)
French (fr)
Other versions
EP1851227A1 (en
Inventor
Xun Li
Sebastien Lemaire
Istvan Marko
Albert Willemsens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Priority claimed from PCT/US2006/006061 external-priority patent/WO2006093719A1/en
Publication of EP1851227A1 publication Critical patent/EP1851227A1/en
Publication of EP1851227A4 publication Critical patent/EP1851227A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
EP06735630A 2005-02-25 2006-02-21 An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one Withdrawn EP1851227A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65635305P 2005-02-25 2005-02-25
US66595405P 2005-03-29 2005-03-29
PCT/US2006/006061 WO2006093719A1 (en) 2005-02-25 2006-02-21 An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one

Publications (2)

Publication Number Publication Date
EP1851227A1 EP1851227A1 (en) 2007-11-07
EP1851227A4 true EP1851227A4 (en) 2010-03-10

Family

ID=38561458

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06735630A Withdrawn EP1851227A4 (en) 2005-02-25 2006-02-21 An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one

Country Status (2)

Country Link
EP (1) EP1851227A4 (en)
JP (1) JP2008531570A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014046145A1 (en) * 2012-09-24 2014-03-27 コニカミノルタ株式会社 Photoelectric conversion element and method for manufacturing same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087882A2 (en) * 2000-05-17 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087882A2 (en) * 2000-05-17 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
See also references of WO2006093719A1 *
WEIQIN JIANG ET AL.: "Furoyl and benzofuroyl Pyrroloquinolones as Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 3, 2003, pages 441 - 444, XP002564494 *
WEIQIN JIANG ET AL.: "Potassium Superoxide as an Alternative Reagent for Winterfeldt Oxidation of beta-Carbolines", ORGANIC LETTERS, vol. 5, no. 1, 2003, pages 43 - 46, XP002564493 *
WEIQIN JIANG ET AL.: "Synthesis of optically pure pyrroloquinolones via Pictet-Spengler and Winterfeldt reactions", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 43, no. 49, 2 December 2002 (2002-12-02), pages 8941 - 8945, XP004391871, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
JP2008531570A (en) 2008-08-14
EP1851227A1 (en) 2007-11-07

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