EP1830665A1 - Haustierfutter - Google Patents

Haustierfutter

Info

Publication number
EP1830665A1
EP1830665A1 EP05817621A EP05817621A EP1830665A1 EP 1830665 A1 EP1830665 A1 EP 1830665A1 EP 05817621 A EP05817621 A EP 05817621A EP 05817621 A EP05817621 A EP 05817621A EP 1830665 A1 EP1830665 A1 EP 1830665A1
Authority
EP
European Patent Office
Prior art keywords
egcg
weight
green tea
pet food
food
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05817621A
Other languages
English (en)
French (fr)
Inventor
Stephanie Krammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Priority to EP05817621A priority Critical patent/EP1830665A1/de
Publication of EP1830665A1 publication Critical patent/EP1830665A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A23K50/48—Moist feed
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs

Definitions

  • the present invention relates to pet food more particularly to that capable of preventing periodontal diseases of dogs and cats.
  • Pet food is processed from fish, meat, milk and the like with additional dairy products, vegetables, vitamins and so on.
  • pet food such as dry- type food in which less than 10 % of water is contained, semi-moist-type food in which 20- 40 % of water is contained and wet-type food in which more than 70 % of liquid, i.e. water or milk is contained.
  • wet-type cat food containing more than 70% water or milk, are packed in containers by about 100 g.
  • pet food having a deodorant effect so that feces and urine of cats and dogs may not make a foul smell.
  • Such pet food often contains a very small quantity (from 0.01 to 0.02 % by weight) of a green tea extract as an additive, which has an antibacterial effect.
  • the feed of green tee extracts to cats and dogs has a big disadvantage. Since the green tea extract has a bitter and stringent taste because of tannin, its principal ingredient, it is hard for cats and dogs to take it. Therefore in order to let the pets take the extract spontaneously every day only a few manufacturers add a very small quantity of that to pet food.
  • the present invention provides pet food comprising Epigallocatechingallate (EGCG) as a green tea extract in a concentration of from 0.001% to 3% by weight, for example from 0.01% to 3% by weight, preferably from 0.1% to 2% by weight.
  • EGCG is a polyphenol derived from the green tea plant Camellia sinensis. It may be added to the cat food in any form, including, e.g., green tea extracts containing varying amounts of EGCG as well as highly enriched EGCG preparations such as the EGCG preparation obtained by the process as described in EP 1,077,211. In this process EGCG is highly enriched starting from any green tea extract, e.g.
  • green tea leaves are typically extracted with hot or cold water to form a solution containing tea catechins and caffeine .
  • This green tea solution can be further concentrated to form either a concentrated extract solution or a dry powder.
  • Tea extract powders are commercially available e. g. from Guizhou Highyin Biological Product Co., Guiyang, P. R. China, or Zhejang Zhongke Plant Technical Co. Ltd., Hangzhou, Zhejang, P. R. China.
  • EGCG is present in the compositions of the present invention in a concentration of from about 0.001 to about 3 % (w/w).
  • the green tea extract i.e. EGCG
  • bacteria in the oral cavities of pets can be reduced and inflammatory diseases can be suppressed since the green tea extract, i.e. EGCG has an antibacterial effect.
  • the present invention provides dry- and wet-type pet food containing EGCG in a concentration of from 0.001% to 3% by weight, for example from 0.01% to 3% by weight, preferably from 0.1% to 2% by weight.
  • the present invention provides wet-type cat food containing from 0.001% to 3% by weight of a green tea extract.
  • Cat milk a preferred wet- type cat food preferably contains EGCG in an amount from about 0.1 mg/kg diet to about 300 mg/kg diet.
  • the present invention relates to the use of EGCG in the manufacture of a pet food for preventing or treating plaque, gingivitis, periodontal disease and oral malodor (halitosis) in cats and dogs, and for enhancing the antioxidative capacity in the whole organism; and for the use of the aforesaid ingredient for preventing or treating plaque, gingivitis, periodontal disease and oral malodor (halitosis) in cats and dogs, and for enhancing the antioxidative capacity in the whole organism.
  • the pet food contains EGCG in an amount sufficient to administer to a subject a daily dosage of 0.1 mg per kg body weight to about 100 mg, preferably 20 mg per kg body weight.
  • the present invention relates to the use of EGCG in the manufacture of a pet food for weight reduction in cats and dogs.
  • the pet food contains EGCG in an amount sufficient to administer to a subject a daily dosage of 0.1 mg per kg body weight to about 100 mg, preferably 20 mg per kg body weight.
  • the pet food according to the present invention contains for example EGCG in a concentration of about 30 mg/kg by weight to about 1000 mg/kg by weight, based on the total weight of the pet food and may be based on any conventional pet food.
  • EGCG in a concentration of about 30 mg/kg by weight to about 1000 mg/kg by weight, based on the total weight of the pet food and may be based on any conventional pet food.
  • Complete diets may be fed in addition to water for an extended period as the sole source of nutrients and will provide for all the energetic and nutrient needs of the animal and the physiological state for which it is intended.
  • Complementary diets normally are not sufficient to ensure that all nutrient and energy requirements are met unless fed in combination with another foodstuff or diet. Snacks and treats are appetizers or for occasional feeding and are considered as complementary products.
  • the pet food of the present invention may be in a dry, canned, semi -moist or baked form.
  • Typical components of such compositions are crude protein, crude fat, carbohydrates, starch, crude fibers, and ash, further on minerals, trace elements, vitamins, fatty acids, protein and amino acids, choline, carnitin, dietary fiber and substances required for balanced diets of the different animal species.
  • Basic ingredients of such food compositions are: - Crude Protein including proteins and N-containing compounds of non-proteinaceous nature, e.g. acid amides, amines, free amino acids, ammonium salts, alkaloids;
  • NFE N-free Extractions
  • polysaccharides starch, glycogen
  • soluble saccharides glucose, fructose, saccharose, lactose, maltose and oligosaccharides
  • soluble fractions of cellulose, hemicellulose, lignin and pectines - Crude Fibers including insoluble fractions of cellulose, hemicellulose, lignin and other components of the cell wall like suberin, cutin etc.
  • Ash including minerals (macrominerals such as calcium, phosphorus, sodium, chloride, potassium, magnesium, and microminerals, i.e., trace elements, such as iron, copper manganese, zinc, iodine, selenium,) and further inorganic substances e.g. silicate.
  • minerals such as calcium, phosphorus, sodium, chloride, potassium, magnesium, and microminerals, i.e., trace elements, such as iron, copper manganese, zinc, iodine, selenium,
  • inorganic substances e.g. silicate.
  • Vitamins including vitamins A, Bl, B2, B6, B 12, D, pantothenic acid, niacin, biotin, folic acid, linolic acid and choline.
  • Further components may, e.g. be omega-6-fatty acids, omega-3-fatty acids, L- carnitine, chondroitin sulfate, glucosamine, glutamine/glutamic acid, arginine, taurine and hydroxyproline.
  • Typical components which provide the ingredients for a dog food composition, in addition to EGCG comprise e.g., chicken/beef/turkey, liver, broken pearl barley, ground corn, brute fat, whole dried egg, fowl protein hydrolyzate, vegetable oil, calcium carbonate, choline chloride, potassium chloride, iodinized salt, iron oxide, zinc oxide, copper sulfate, manganese oxide, sodium selenite, calcium iodate, provitamin D, vitamin Bi, niacin, calcium panthothenate, pyridoxin hydrochloride, riboflavin, folic acid, biotin, vitamin Bi 2 .
  • EGCG e.g., chicken/beef/turkey, liver, broken pearl barley, ground corn, brute fat, whole dried egg, fowl protein hydrolyzate, vegetable oil, calcium carbonate, choline chloride, potassium chloride, iodinized salt, iron oxide, zinc oxide, copper sulfate, manganes
  • Typical components which provide the ingredients for a cat food composition comprise beef, chicken meat, dried chicken liver, lamb meat, lamb liver, pork, turkey meat, turkey liver, poultry meal, fish meal, fowl protein hydrolysate, animal fats, plant oils, soy bean meal, pea bran, maize gluten, whole dry egg, ground corn, corn flour, rice, rice flour, dry sugar beet molasses, fructooligosaccharides, soluble fibres, plant gums, cellulose powder, clay, bakers yeast, iodized sodium chloride, calcium sulfate, sodium triphosphate, dicalcium phosphate, calcium carbonate, potassium chloride, choline chloride, magnesium oxide, zinc oxide, iron oxide, copper sulfate, iron sulfate, manganese oxide, calcium jodate, sodium selenite, provitamin D, thiamine, niacin, calcium pantothenate, pyridoxine hydrochloride, riboflavin,
  • Wet pet food contains about 70% and more moisture.
  • a typical wet food for adult dogs may, e.g. comprise, in addition to EGCG, at minimum 24 % protein, 15 % fat, 52 % starch, 0.8 % fibre, 3 % linolic acid, 0.6 % calcium, 0.5 % phosphorus, the Ca:P ratio being 1:1, 0.2 % potassium, 0.6 % sodium, 0.09 % chloride, 0.09 % magnesium, 170 mg/kg of iron, 15 mg/kg of copper, 70 mg/kg of manganese, 220 mg/kg of zinc, 4 mg/kg of iodine, 0.43 mg/kg of selenium, 74000 IU/kg of vitamin A, 1200 IU/kg of vitamin D, 11 mg/kg of vitamin B 1 , 6 mg/kg of riboflavin, 30 mg/kg of pantothenic acid, 20 mg/kg of niacin, 4.3 mg/kg of pyridoxine, 0.9 mg/kg of folic acid, 0.2 ⁇ g/kg of vitamin
  • a typical wet food for adult cats may, e.g. comprise, in addition to EGCG, at minimum 44 % protein, 25 % fat, 20 % starch, 2.5 % fibre, 0.8 % calcium, 0.6 % phosphorus, 0.8 % potassium, 0.3 % sodium, 0.09 % chloride, 0.08 % magnesium, 0.25 % taurin, 170 mg/kg of iron, 15 mg/kg of copper, 70 mg/kg of manganese, 220 mg/kg of zinc, 4 mg/kg of iodine, 0.43 mg/kg of selenium, 74000 IU/kg of vitamin A, 1200 IU/kg of vitamin D, 11 mg/kg of vitamin Bl, 6 mg/kg of riboflavin, 30 mg/kg of pantothenic acid, 20 mg/kg of niacin, 4.3 mg/kg of pyridoxine, 0.9 mg/kg of folic acid, 0.2 ⁇ g/kg of vitamin B12, 2500 mg/kg of choline
  • Dry pet food contains between about 6 and aboutH % moisture and about 86% and more dry matter.
  • a typical dry food for adult dogs may, e.g. comprise, in addition to EGCG, at minimum 25 % protein, 12 % fat, 41.5 % starch, 2.5 % fibre, 1 % linolic acid, 1 % calcium, 0.8 % phosphorus, the Ca:P ratio being 1 :1, 0.6 % potassium, 0.35 % sodium, 0.09 % chloride, 0.1 % magnesium, 170 mg/kg of iron, 35 mg/kg of copper, 70 mg/kg of manganese, 220 mg/kg of zinc, 4 mg/kg of iodine, 0.43 mg/kg of selenium, 15000 IU/kg of vitamin A, 1200 IU/kg of vitamin D, 11 mg/kg of vitamin B 1 , 6 mg/kg of riboflavin, 30 mg/kg of pantothenic acid, 20 mg/kg of niacin, 4.3 mg/kg of pyridoxine, 0.9 mg/kg of folic acid, 0.2 ⁇ g/kg of vitamin Bi
  • a preferred cat food composition of the present invention is in the form of a wet-type milk product.
  • a typical wet-type milk food for cats may, e.g. comprise, in addition to EGCG, at minimum 3 % raw protein, 2 % raw fat, 0.5% to 0.3% ashes, at minimum 80% moisture, 0.8% raw starch, vitamins A, E, Bl, B2, B6 and/or B12 in a range of from O.OOlmg to about 5 mg per kg food, wherein all percentages being based on dry weight of the total food composition.
  • Dry food may be prepared, e.g., by screw extrusion including cooking, shaping and cutting of raw ingredients into a specific kibble shape and size in a very short period of time, while simultaneously destroying detrimental micro-organisms.
  • the ingredients may be mixed into homogenous expandable dough and cooked in an extruder (steam/pressure) and forced through a plate under pressure and high heat. After cooking, the kibbles are then allowed to cool, before optionally being sprayed with a coating which may include liquid fat or digest including liquid or powdered hydro lyzed forms of an animal tissue such as liver or intestine from, e.g., chicken or rabbit. Hot air drying then reduces the total moisture content to 10 % or less.
  • Canned (wet) food may be prepared, e.g., by blending the raw ingredients including meats and vegetables, fatty acids, gelling agents, gravies, vitamins, minerals and water. The mix is then fed into cans on a production line, the lids are sealed on and the filled cans are sterilized at a temperature of about 13O 0 C for about 50 to 100 min.
  • the pet foods of the present invention are useful in preventing or treating plaque, gingivitis, periodontal disease and oral malodor (halitosis) in dogs and cats, and for enhancing the antioxidative capacity in the whole organism.
  • Plaque is a soft, gelatinous material composed of bacteria and their metabolic byproducts, oral debris, and salivary components. Mature plaque is not removed by normal actions of the tongue or by rising of the mouth. Rather, mechanical abrasion from chewing or tooth brushing is necessary for plaque removal.
  • gingivitis persists without progressing into periodontitis. However, in most, untreated gingivitis eventually progresses to periodontal disease. Clinical signs of gingivitis and periodontal disease include oral malodor, gingival sensitivity and bleeding, tooth loss, and difficulty in eating.
  • halitosis Oral malodor (halitosis) is commonly reported in cats and is perceived by many owners to be a significant problem. Being associated with gingivitis and periodontitis one explanation for halitosis may be that chronic inflammation and tissue damage provides increased protein substrate for microorganisms in the mouth, enhancing the production of VSCs, volatile sulfur compounds. These compounds, particularly mercaptyl sulfide and hydrogen sulfide, produce breath malodor when exhaled.
  • Odontoclastic resorptive lesions in cats also have been associated with gingival inflammation and, possibly, periodontal disease. Since the majority of periodontal pathogens are gram-negative bacteria which release endotoxins (lipopolysaccharides - LPS) dental diseases are a potential risk factor for systemic disease in cats resulting in a systemic bacteremia or LPS challenge.
  • endotoxins lipopolysaccharides - LPS
  • the importance of maintaining healthy periodontal tissues is of greater significance when considered that chronic periodontal disease my have a systemic as well as local effects.
  • the most important factor that influences the development of gingivitis and periodontal disease in the dog and cat is the presence and persistence of undisturbed plaque on tooth surface. Once plaque has been deposited on the surface of the tooth, it may be reduced mechanically through abrasion provided by diet, chewing on supplemental chew toys or foods.
  • antimicrobial agents like chlorhexidine digluconate in conjunction with brushing, and the use of a chemical mouthwash is not effective in removing the hardened calculus that forms when plaque is allowed to accumulate.
  • Antioxidative capacity in the whole organism is a means to reflect the organism's capability to withstand oxidative stress and protect cell membrane and cytosolic components against free radical damage. The higher the antioxidative capacity the higher its ability to neutralize free radicals and arrest the chain effect of free radical damage thereby playing a vital role in maintaining the health and integrity of individual cells.
  • the amount of plaque forming bacteria may be determined by counting the bacteria commonly considered responsible for the pathogenesis of periodontitis, e.g. Streptococcus mutans, Eikenella corrodens and Porphyromonas gingivalis, and further Prevotella ssp, Bacteroides gingivalis, Bacteroides intermedius, Actinobacillus and Actinobacillus.
  • subgingival plaque may be taken from the maxillary premolars of dogs with a scalar.
  • Saliva, tongue dorsum and bucal mucosa may be obtained as cotton swabs.
  • Each specimen may be placed immediately, e.g., in sterile oxygen free tubes containing, e.g.
  • each sample may, e.g., be placed on Brain Heart Infusion agar with 7% horse blood for total counts, and Brucella HK agar with 7% horse blood for counts of genus Porphyromonas as black-pigmented bacteria.
  • Identification and bacterial count of representative colonies may be carried out using Rapid ANA II system, AIP 2OA and API-ZYM systems.
  • Streptococcus mutans a Brain Heart Infusion would be used, too. The conditions used would be aerobic. After incubation at 37°C for 48 hours, MICs would be estimated using the systems mentioned above.
  • Gingivitis oral inflammation
  • gingival index a method for estimating severity of inflammation of the gums.
  • a total blood count may be carried out.
  • Red blood cell count Hemoglobin, hematocrit, number of erythrocytes, erythrocyte indices MCHC, MCH, MCV.
  • White blood cell count Total number of leukocytes, differential blood count (Basophiles, neutrophiles, eosinophiles, monocytes, thrombocytes, B - and T- lymphocytes) relative and absolute.
  • Parameters for the determination of the antioxidant capacity include TEAC (Trolox equivalent antioxidant capacity) which may be measured, e.g. after a 1 : 1 dilution with a spctrophotometer, on which absorbance values were recorded over 3 minutes, according to the method of Armstrong and Browne, Adv Exp Med Biol 366:43-58 (1994), Total
  • TAC Antioxidant Capacity
  • SOD Erythrocyte Superoxid Dismutase
  • TAC Antioxidant Capacity
  • SOD Erythrocyte Superoxid Dismutase
  • EGCG as supplied by DSM Nutritional Products Ltd.
  • Vitamin C and E and ⁇ -carotene are incorporated in an amount sufficient to provide 30 mg vitamin C/kg, and 300 IU vitamin E/kg and 280 mg ⁇ -carotene/kg in the final food composition before extruding the entire blend.
  • the food composition is dried to contain dry matter of about 90 % by weight.
  • EGCG as supplied by DSM Nutritional Products Ltd.
  • Vitamin C and E and ⁇ -carotene are incorporated in an amount sufficient to provide 30 mg vitamin C/kg, and 300 IU vitamin E/kg and 280 mg ⁇ -carotene/kg in the final food composition before cooking the entire blend.
  • the food composition is dried to contain a dry matter of about 90% by weight.
  • EGCG as supplied by DSM Nutritional Products Ltd.
  • Vitamin C and E and ⁇ -carotene are incorporated in an amount sufficient to provide 30 mg vitamin C/kg, and 300 IU vitamin E/kg and 280 mg ⁇ -carotene/kg in the final food composition before extruding the entire blend.
  • the food composition is dried to contain a dry matter of about 90 % by weight.
  • EGCG as supplied by DSM Nutritional Products Ltd.
  • F Further Vitamin C and E and ⁇ - carotene are incorporated in an amount sufficient to provide 30 mg vitamin C/kg, and 300 IU vitamin E/kg and 280 mg ⁇ -carotene/kg in the final food composition before extruding the entire blend.
  • the food composition is dried to contain a dry matter of about 90 % by weight.
  • EGCG as supplied by DSM Nutritional Products Ltd.
  • Vitamin C and E and ⁇ - carotene are incorporated in an amount sufficient to provide 30 mg vitamin C/kg, and 300 IU vitamin E/kg and 280 mg ⁇ -carotene/kg in the final food composition before cooking the entire blend.
  • the food composition is dried to contain a dry matter of about 90 % by weight.
  • EGCG (as supplied by DSM Nutritional Products Ltd.) in aqueous solution and in an amount sufficient to provide 0.001% to 3.0% by weight of EGCG in the final food composition is added.
  • EGCG (as supplied by DSM Nutritional Products Ltd.) in aqueous solution and in an amount sufficient to provide 0.001% to 3.0 % by weight of EGCG in the final food composition is added.
  • Periodontopathic conditions are the most common disease in dogs and cats. Especially in cats, prophylaxis is usually limited to professional dental cleaning under anaesthesia. Special diets which reduce plaque and calculus accumulation have been formulated to extend the period of time between professional dental cleanings. The study was conducted to determine the effect of EGCG in a regular dry diet on the oral health of cats. In addition, the in vitro antibacterial activity of the substance and its effect on the antioxidant status of cats were evaluated.
  • the substance under investigation was sprayed on a standard dry cat food.
  • the supplemented diet contained 227 mg/kg of EGCG.
  • the study group was given the prepared feed (epigallocatechingallate) and the control group was given the placebo feed.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Birds (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
EP05817621A 2004-12-31 2005-12-19 Haustierfutter Withdrawn EP1830665A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05817621A EP1830665A1 (de) 2004-12-31 2005-12-19 Haustierfutter

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04031082 2004-12-31
PCT/EP2005/013641 WO2006069662A1 (en) 2004-12-31 2005-12-19 Pet food
EP05817621A EP1830665A1 (de) 2004-12-31 2005-12-19 Haustierfutter

Publications (1)

Publication Number Publication Date
EP1830665A1 true EP1830665A1 (de) 2007-09-12

Family

ID=35767632

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05817621A Withdrawn EP1830665A1 (de) 2004-12-31 2005-12-19 Haustierfutter

Country Status (2)

Country Link
EP (1) EP1830665A1 (de)
WO (1) WO2006069662A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2090178A1 (de) * 2008-02-13 2009-08-19 Bühler AG Haustier-Nahrungsmittelprodukt und Verfahren zu seiner Herstellung
NL2005194C2 (en) * 2010-08-05 2012-02-07 Eric Jan Ostwald Pharmaceutical composition for use in the prevention and treatment of gingivitis and parodontitis.
CN106998755A (zh) 2014-12-17 2017-08-01 希尔氏宠物营养品公司 用于减轻或治疗口腔炎症的组合物和方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2963887B2 (ja) * 1997-11-11 1999-10-18 いなば食品株式会社 キャットフード
US6428817B1 (en) * 1999-07-06 2002-08-06 Peter Donald Collin Companion animal therapeutic treat
JP2005533864A (ja) * 2002-07-26 2005-11-10 ディーエスエム アイピー アセッツ ビー．ブイ． ラクトフェリンを含む組成物
PT1581199E (pt) * 2002-09-09 2015-04-27 Nestec Sa Composição oralmente adiminstrável para melhorar a qualidade da pele

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2006069662A1 *

Also Published As

Publication number Publication date
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