EP1817062A4 - Radiation dosimetry and blocking antibodies and methods and uses threfor in the treatment of cancer - Google Patents

Radiation dosimetry and blocking antibodies and methods and uses threfor in the treatment of cancer

Info

Publication number
EP1817062A4
EP1817062A4 EP05856975A EP05856975A EP1817062A4 EP 1817062 A4 EP1817062 A4 EP 1817062A4 EP 05856975 A EP05856975 A EP 05856975A EP 05856975 A EP05856975 A EP 05856975A EP 1817062 A4 EP1817062 A4 EP 1817062A4
Authority
EP
European Patent Office
Prior art keywords
threfor
cancer
treatment
methods
blocking antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP05856975A
Other languages
German (de)
French (fr)
Other versions
EP1817062A2 (en
Inventor
Gamal Akabani-Hneide
Darell D Bigner
Michael R Zalutsky
David A Rizzieri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of EP1817062A2 publication Critical patent/EP1817062A2/en
Publication of EP1817062A4 publication Critical patent/EP1817062A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1066—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1014—Intracavitary radiation therapy
    • A61N5/1015—Treatment of resected cavities created by surgery, e.g. lumpectomy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
EP05856975A 2004-11-17 2005-11-17 Radiation dosimetry and blocking antibodies and methods and uses threfor in the treatment of cancer Ceased EP1817062A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62874004P 2004-11-17 2004-11-17
US62890204P 2004-11-17 2004-11-17
PCT/US2005/041884 WO2006073586A2 (en) 2004-11-17 2005-11-17 Radiation dosimetry and blocking antibodies and methods and uses threfor in the treatment of cancer

Publications (2)

Publication Number Publication Date
EP1817062A2 EP1817062A2 (en) 2007-08-15
EP1817062A4 true EP1817062A4 (en) 2010-01-20

Family

ID=36647943

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05856975A Ceased EP1817062A4 (en) 2004-11-17 2005-11-17 Radiation dosimetry and blocking antibodies and methods and uses threfor in the treatment of cancer

Country Status (8)

Country Link
US (1) US20060127311A1 (en)
EP (1) EP1817062A4 (en)
JP (1) JP2008520707A (en)
AU (1) AU2005323377A1 (en)
CA (1) CA2587172A1 (en)
RU (1) RU2007121808A (en)
WO (1) WO2006073586A2 (en)
ZA (1) ZA200704642B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101636412A (en) * 2007-03-30 2010-01-27 霍夫曼-拉罗奇有限公司 Mark and composition cold monoclonal antibody
CN114404429B (en) * 2021-11-30 2023-06-30 重庆医科大学附属第二医院 Nanometer silver modified tannic acid-iron network drug-loaded nanometer compound and preparation method and application thereof in reversing tumor drug resistance
WO2024181576A1 (en) * 2023-03-02 2024-09-06 日本メジフィジックス株式会社 Radioactive metal labeled antibody, radiopharmaceutical, and compound

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034632A1 (en) * 1995-05-04 1996-11-07 The Regents Of The University Of Michigan Method of establishing the optimal radiation dose for radiopharmaceutical treatment of disease
WO1999062565A2 (en) * 1998-06-04 1999-12-09 Coulter Pharmaceutical, Inc. Patient-specific dosimetry

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
USRE38008E1 (en) * 1986-10-09 2003-02-25 Neorx Corporation Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
US6787153B1 (en) * 1991-06-28 2004-09-07 Mitsubishi Chemical Corporation Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
AU6445894A (en) * 1993-03-19 1994-10-11 Duke University Method of treatment of tumors with an antibody binding to tenascin
GB9314623D0 (en) * 1993-07-14 1993-08-25 Nordion Int Inc Localization and therapy with agents directed against prostate specific antigen in breast cancer
US5874540A (en) * 1994-10-05 1999-02-23 Immunomedics, Inc. CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
EP1047457A2 (en) * 1998-01-16 2000-11-02 MCA Development B.V. USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE
US6312694B1 (en) * 1998-07-13 2001-11-06 Board Of Regents, The University Of Texas System Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
US20020187100A1 (en) * 2000-12-21 2002-12-12 David Rizzieri Anti-tenascin monoclonal antibody therapy for lymphoma
US6455026B1 (en) * 2001-03-23 2002-09-24 Agy Therapeutics, Inc. Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors
US7011814B2 (en) * 2001-04-23 2006-03-14 Sicel Technologies, Inc. Systems, methods and devices for in vivo monitoring of a localized response via a radiolabeled analyte in a subject

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034632A1 (en) * 1995-05-04 1996-11-07 The Regents Of The University Of Michigan Method of establishing the optimal radiation dose for radiopharmaceutical treatment of disease
WO1999062565A2 (en) * 1998-06-04 1999-12-09 Coulter Pharmaceutical, Inc. Patient-specific dosimetry

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AKABANI G ET AL: "DOSIMETRY AND DOSE-RESPONSE RELATIONSHIPS IN NEWLY DIAGNOSED PATIENTS WITH MALIGNANT GLIOMAS TREATED WITH IODINE-131-LABELED ANTI-TENASCIN MONOCLONAL ANTIBODY 81C6 THERAPY", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS, PERGAMON PRESS, USA, vol. 46, no. 4, 1 January 2000 (2000-01-01), pages 947 - 958, XP000939295, ISSN: 0360-3016, DOI: 10.1016/S0360-3016(99)00500-3 *
AKABANI G ET AL: "DOSIMETRY OF 131 I-LABELED 81C6 MONOCLONAL ANTIBODY ADMINISTERED INTO SURGICALLY CREATED RESECTION CAVITIES IN PATIENTS WITH MALIGNANT BRAIN TUMORS", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, RESTON, VA, US, vol. 40, 1 April 1999 (1999-04-01), pages 631 - 638, XP000931279, ISSN: 0161-5505 *
WAHL R L ET AL: "Patient-specific whole-body dosimetry: principles and a simplified method for clinical implementation", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, RESTON, VA, US, vol. 39, no. 8, SUPPL, 1 August 1998 (1998-08-01), pages 14S - 20S, XP002126650, ISSN: 0161-5505 *

Also Published As

Publication number Publication date
RU2007121808A (en) 2008-12-27
WO2006073586A8 (en) 2007-02-22
AU2005323377A1 (en) 2006-07-13
EP1817062A2 (en) 2007-08-15
ZA200704642B (en) 2008-07-30
CA2587172A1 (en) 2006-07-13
JP2008520707A (en) 2008-06-19
US20060127311A1 (en) 2006-06-15
WO2006073586A3 (en) 2006-11-23
WO2006073586A2 (en) 2006-07-13

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