EP1813595A1 - 3(4),7(8)-Bis (aminomethyl)-bicyclo[4.3.0] nonan and a method for its manufacture - Google Patents

Abstract

Preparation of 3(4),7(8)-bis(aminomethyl)-bicyclo[4.3.0]nonane (I) by hydroformylation comprises reaction of bicyclo[4.3.0]nona-3,7-diene (Ia) with synthesis gas in homogeneous organic phase in the presence of transition metal compounds of group VIII of the periodic table containing complex-bound organophosphorus compounds and excess organophosphorus compounds, at 70-160[deg]C and 5-35 MPa and reductive amination of the obtained 3(4),7(8)-bisformylbicyclo[4.3.0]nonane gives (I). An independent claim is included for a chemical compound such as 3(4),7(8)-bis(aminomethyl)-bicyclo[4.3.0]nonane, obtained by the above process.

Description

The present invention relates to the chemical compound 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane and a process for their preparation from bicyclo [4.3.0] nona-3,7-diene.

Condensed, alicyclic, unsaturated hydrocarbons with isolated double bonds in the rings are valuable starting materials that can be converted into useful compounds. The ring-shaped and condensed hydrocarbon skeleton gives it special properties. An important example of this class of compounds is the dicyclopentadiene (DCP), which is easily accessible and also industrially produced by dimerization of cyclopentadiene and which can be converted into compounds which are important in terms of application, to which the tricyclodecane skeleton confers special properties. The DCP-derived compounds having a tricyclodecane structure are also frequently referred to in the literature as TCD derivatives ( Chemiker-Zeitung, 98, 1974, pages 70-76 ).

In particular, the hydroformylation of DCP provides interesting TCD aldehydes, such as 3 (4), 8 (9) -bis-formyl-tricyclo [5.2.10 ^2.6 ] decane, also referred to as TCD-dialdehyde, which is further processed to important intermediates.

Because of their thermal lability, which leads to losses in the workup by distillation, TCD dialdehyde is usually not purely isolated, but further processed as a crude product of the hydroformylation reaction. For example, the reductive amination of TCD-dialdehyde leads to TCD-diamine {3 (4), 8 (9) -bis (aminomethyl) -tricyclo [5.2.1.0 ^2.6 ] decane}, which is used as a valuable intermediate in many technically-advanced syntheses For example, for the production of light-resistant polyurethane systems according to DE 28 19 980 A1 , for the production of dental materials ( WO2002 / 013767 A2 . EP 678 533 A2 ), for the synthesis of polyamides ( EP 168 816 A2 ), polyfunctional epoxy resin systems ( JP 58 135 875 A ), thermosetting coating materials ( EP 59 962 A1 ), of epoxy resin hardeners ( JP 54 004 992 A ) and for the preparation of TCD-diisocyanate ( NL 66 14 717 A ).

The preparation of aldehydes by catalytic addition of carbon monoxide and hydrogen to olefinic double bonds is known. While this reaction was previously carried out almost exclusively with cobalt as the catalyst, modern methods using metallic rhodium or with rhodium compounds as catalysts which are used alone or with complex-forming ligands, for example organic phosphines or esters of phosphorous acid. Hydrogencarbonyl compounds of rhodium, which can be represented by the general formula H [Rh (CO) _4-x L _x ], where L denotes a ligand and x is 0 or an integer, are effective under the reaction conditions as a catalyst from 1 to 3.

A special case is the hydroformylation of dienes. Whereas in the hydroformylation of conjugated dienes almost exclusively monoaldehydes are obtained under the customary conditions of oxo synthesis, dicyclopentadiene (DCP) with its isolated double bonds can be used in addition to mono- and disubstitution products. Due to the Great importance of the hydroformylation of DCP are also in the technical literature numerous papers that deal both with the hydroformylation reaction of DCP and with the subsequent workup of the crude product. So treat DE 38 22 038 A1 and GB 1 170 226 the hydroformylation of DCP in the presence of rhodium in an organic solvent at elevated pressure and elevated temperature. A summary of the hydroformylation of dicyclopentadiene can be found in the Chemist Newspaper 98, 1974, 70-76 , which also refers to the thermal lability of the TCD aldehydes, which leads to high product losses in the workup by distillation of the crude hydroformylation mixture. Therefore, TCD dialdehydes are usually not purely isolated, but further processed in their mixtures with the by-products of the oxo synthesis. It can be found in the prior art, eg in EP-1 065 194 A1 or US 5,138,101 A but also evidence of extractive work-up processes without thermal stress. In this case, the organic crude mixture is extracted with a polar organic solvent, for example with a polyhydric alcohol or with a methanol / water mixture, wherein the TCD dialdehydes go into the polar, alcoholic phase and the hydroformylation catalyst remains in the hydrocarbon phase.

The production of TCD-diamine is out DE 38 22 038 A1 known. Thereafter, dicyclopentadiene is hydroformylated in organic solution in the presence of rhodium to give crude TCD-dialdehyde which is then reductively aminated without further separation of the TCD-dialdehyde and without removal of the catalyst in a second reaction step in the presence of a primary amine.

After JP 10 087 573 A the preparation of TCD-diamine is carried out by hydrogenating the corresponding TCD-dialdehyde dioxime in the presence of Fe-Cr-modified Raney nickel.

Because of the great economic importance that aminomethylated diamines based on condensed alicyclic hydrocarbons have, therefore, there is a need to provide further, low-cost, high-purity aminomethylated diamines having a ring-shaped, fused-ring hydrocarbon backbone.

The present invention therefore relates to the chemical compound 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane.

The invention also relates to a process for the preparation of 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane by hydroformylation of bicyclo [4.3.0] nona-3,7-diene with the following reductive amination. It is characterized in that bicyclo [4.3.0] nona-3,7-diene in homogeneous organic phase in the presence of complex-bonded organophosphorus compounds containing transition metal compounds of Group VIII of the Periodic Table of the Elements and excess organophosphorus compound at temperatures of 70 to 160 ° C and pressures of 5 to 35 MPa with synthesis gas and the resulting 3 (4), 7 (8) -bis-formyl-bicyclo [4.3.0] nonane then to 3 (4), 7 (8) -Bis ( aminomethyl) -bicyclo [4.3.0] nonane reductively aminated.

The compound according to the invention is derived from bicyclo [4.3.0] nona-3,7-diene, which is prepared industrially by Diels-Alder reaction of butadiene with cyclopentadiene and which is therefore available in inexpensive quantities.

wobei beide Strukturformeln identisch sind.The count of carbon atoms bound in the unsaturated bicyclic hydrocarbon is in the following order:

where both structural formulas are identical.

Compound 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane according to the invention is a mixture of different isomers of bis (aminomethyl) bicyclo [4.3.0] nonane where the aminomethyl group in the six-membered ring may be bonded once at the 3- or the 4-position and the aminomethyl group in the five-membered ring once at the 7- or 8-position.

wobei beide Strukturformeln identisch sind.In analogy to that in the TCD derivatives according to Chemiker-Zeitung, 98, 1974, pages 70-76 conventional notation, compound 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane according to the invention can be formally described as follows:

where both structural formulas are identical.

The starting product bicyclo [4.3.0] nona-3,7-diene can be added as such or in solution to the hydroformylation. Suitable solvents are those in which starting material, reaction product and catalyst are soluble and which are inert under the reaction conditions, for example water-insoluble ketones, dialkyl ethers, aliphatic nitriles, aromatic hydrocarbons such as benzene, toluene, the isomeric xylenes or mesitylene and saturated cycloaliphatic hydrocarbons such as cyclopentane or cyclohexane or saturated aliphatic hydrocarbons such as n-hexane, n-heptane or n-octane. The proportion of the solvent in the reaction medium can be varied over a wide range and is usually between 10 and 80 wt .-%, preferably 20 to 50 wt .-%, based on the reaction mixture.

The hydroformylation step is carried out in a homogeneous reaction system. The term homogeneous reaction system stands for a homogeneous solvent composed essentially of solvent, if added in the reaction stage, catalyst, excess organophosphorus compound, unreacted starting compound and hydroformylation product.

The catalysts used are transition metal compounds of Group VIII of the Periodic Table of the Elements containing complexed organophosphorus compounds. Preference is given to complex compounds of cobalt, rhodium, iridium, nickel, iron, platinum, palladium or ruthenium and in particular of cobalt, rhodium and iridium. Particularly preferred is the use of rhodium complex compounds containing organic phosphorus (III) compounds as ligands. Such complex compounds and their preparation are known (eg US Pat. No. 3,527,809 A . US 4 148 830 A . US 4 247 486 A . US 4,283,562 A ). They can be used as uniform complex compounds or as a mixture of different complex compounds. The rhodium concentration in the reaction medium extends over a range of 5 to 1000 ppm by weight and is preferably 10 to 700 ppm by weight. In particular, rhodium is used in concentrations of from 20 to 500 ppm by weight, based in each case on the homogeneous reaction mixture. The hydroformylation is carried out in the presence of a rhodium-organophosphorus complex compound catalyst system and free, ie excess organophosphorus ligand carried out, which does not undergo complex compound with rhodium. The free organophosphorus ligand can be the same as in the rhodium complex compound, but it can also be used by this different ligands. The free ligand may be a unitary compound or consist of a mixture of different organophosphorus compounds. Examples of rhodium-organophosphorus complex compounds that can be used as catalysts are in US Pat. No. 3,527,809 A described. Among the preferred ligands in the rhodium complex catalysts include, for. Triarylphosphines such as triphenylphosphine, trialkylphosphines such as tri- (n-octyl) phosphine, trilaurylphosphine, tri (cyclohexyl) phosphine, alkylarylphosphines, alkyl phosphites, aryl phosphites, alkyl diphosphites and aryl diphosphites. Thus, rhodium complex compounds containing complexed aryl phosphites of the general formula P (OR ¹ ) (OR ² ) (OR ³ ), where at least one of the groups R ¹ , R ² or R ^{3 is} an ortho-substituted phenyl ring, also be used. Suitable complex ligands have proved to be tris (2-tert-butylphenyl) phosphite or tris (2-tert-butyl-4-methylphenyl) phosphite. The rhodium catalyzed hydroformylation of olefins with phosphite-modified complex compounds is out EP 0 054 986 A1 known. Because of its easy accessibility, triphenylphosphine is used particularly frequently.

Usually, in the homogeneous reaction mixture, the molar ratio of rhodium to phosphorus is 1: 5 to 1: 200, but the molar proportion of the phosphorus in the form of organic phosphorus compounds may also be higher. It is preferable to use rhodium and organically bound phosphorus in molar ratios of 1:10 to 1: 100.

If, in the hydroformylation stage, another transition metal of group VIII of the periodic table of the elements is used as rhodium, then this is Transition metal concentration and molar ratio of transition metal to phosphorus in the ranges chosen for rhodium. The respective optimum values can be determined by simple routine tests, depending on the transition metal used in each case.

The conditions under which the hydroformylation takes place can vary within wide limits and be adapted to individual circumstances. They hang u.a. from the feedstock, the selected catalyst system and the desired degree of conversion. Usually, the hydroformylation of bicyclo [4.3.0] nona-3,7-diene is carried out at temperatures of 70 to 160 ° C. Preferably, temperatures of from 80 to 150.degree. C. and in particular from 90 to 140.degree. C. are maintained. The total pressure extends over a range of 5 to 35 MPa, preferably 10 to 30 MPa and in particular 20 to 30 MPa. The molar ratio of hydrogen to carbon monoxide usually ranges between 1:10 and 10: 1, mixtures containing hydrogen and carbon monoxide in a molar ratio of 3: 1 to 1: 3, in particular about 1: 1, are particularly suitable.

The catalyst is usually formed from the components transition metal or transition metal compound, organophosphorus compound and synthesis gas under the conditions of the hydroformylation reaction in the reaction mixture. However, it is also possible first to preform the catalyst and then to feed it to the actual hydroformylation stage. The conditions of preforming generally correspond to the hydroformylation conditions.

To prepare the hydroformylation catalyst, the transition metal of group VIII of the Periodic Table of the Elements, in particular rhodium, is used either in metallic form or as a compound. In metallic form, the transition metal is used either as finely divided particles or deposited in a thin layer on a support, such as activated carbon, calcium carbonate, aluminum silicate, alumina. Suitable transition metal compounds are salts of aliphatic mono- and polycarboxylic acids, such as transition metal 2-ethylhexanoates, acetates, oxalates, propionates or malonates. Furthermore, salts of inorganic hydrogen and oxygen acids, such as nitrates or sulfates, the various transition metal oxides or transition metal carbonyl compounds such as Rh ₃ (CO) ₁₂ , Rh ₆ (CO) ₁₆ , CO ₂ (CO) ₈ , CO ₄ (CO) ₁₆ , Fe (CO) ₅ , Fe ₂ (CO) ₉ , Ir ₂ (CO) ₈ , Ir ₄ (CO) ₁₂ or transition metal complex compounds, eg cyclopentadienyl rhodium compounds, rhodium acetylacetonate, cyclopentadienyl cobalt cyclooctadiene-1,5, Fe (CO) ₃ - Cyclooctadiene-1,5, [RhCl (cyclooctadiene-1,5] ₂ or PtCl ₂ (cyclooctadiene-1,5).) Transition metal halide compounds are less suitable because of their corrosive nature of the halide ions.

Preference is given to transition metal oxides and in particular transition metal acetates and 2-ethylhexanoates. Rhodium oxide, rhodium acetate, rhodium 2-ethylhexanoate, cobalt oxide, cobalt acetate and cobalt 2-ethylhexanoate have proven to be particularly suitable.

The hydroformylation step can be carried out either batchwise or continuously. In the process of the invention, the starting olefin bicyclo [4.3.0] nona-3,7-diene is almost completely reacted and a crude hydroformylation product is obtained with a high content of the desired bis-formyl product, generally greater than 75% by weight to the crude hydroformylation product.

The reaction product of the hydroformylation stage is reductively aminated without further purification and without catalyst removal.

Reductive amination is the reaction of 3 (4), 7 (8) -bis-formyl-bicyclo [4.3.0] nonane with hydrogen and ammonia in the presence of a hydrogenation catalyst. However, it is also possible first to react the dialdehyde with a primary amine to form a diazomethine and then treat the diazomethine with hydrogen and ammonia in the presence of a hydrogenation catalyst. This reaction is referred to in the context of the invention as a reductive amination.

To form the diazomethine is added to the unreacted hydroformylation per mole of 3 (4), 7 (8) -Bisformyl-bicyclo [4.3.0] nonane 2 to 6 mol, especially 3 to 4 mol of a primary amine. The reaction between the starting materials already proceeds at room temperature, it can be accelerated by heating to 20 to 60 ° C, in particular 30 to 50 ° C. Suitable primary amines are amines having 2 to 10 carbon atoms in the molecule. With particular success amines having 3 to 5 carbon atoms in the molecule, preferably n-butylamine, are used.

The reductive amination of the dialdehyde or diazomethine is advantageously carried out at temperatures of 60 to 150 ° C, preferably 80 to 140 ° C. The hydrogen pressure in the reaction vessel is 2 to 12 and in particular 8 to 10 MPa at the reaction temperature.

As hydrogenation catalysts nickel or cobalt are used, either in the form of Raney nickel or Raney cobalt or in the form of appropriate supported catalysts. A preferred catalyst contains 50 to 60 wt% nickel on kieselguhr.

Ammonia should be expediently used in excess. Per mole of formyl group or per mole diazomethine group at least 2 moles of ammonia are required, preferably 4 to 10 moles of ammonia are used.

The reductive amination of the dialdehyde or diazomethine can be carried out in the absence of solvents, usually the end product itself acts as a solvent. However, in small batch approaches, it is advantageous to work in a solvent. Particularly good results are achieved when using tetrahydrofuran, isobutanol, butanol or isopropanol as a solvent.

The mixture of isomeric diamines is obtained in good yields. Only a small portion of the dialdehydes passes into higher molecular weight condensation products. They are dissolved in the reaction mixture and interfere with the product removal from the reactor and a trouble-free workup of the crude products.

To remove 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane, the reaction mixture is distilled, preferably under reduced pressure. The compounds are obtained as a colorless liquid which, for example, boils at about 149.degree. C. under a pressure of 5 hPa. The hydrogenation catalyst and the transition metal used in the hydroformylation stage accumulate in the distillation residue and are recovered by known methods.

However, the reaction product of the hydroformylation of bicyclo [4.3.0] nona-3,7-diene can also initially be distilled by conventional methods and can be reductively aminated as a purified product. Surprisingly, 3 (4), 7 (8) -bisformyl-bicyclo [4.3.0] nonane can be obtained in pure form with high distillative yield. This is all the more surprising because the prior art points to the thermal lability of dialdehydes with fused, alicyclic ring structures. Transition metal, preferably rhodium and added organophosphorus compound are obtained in the distillation residue and are prepared by known methods recovered. The subsequent reductive amination of the purified 3 (4), 7 (8) -bisformyl-bicyclo [4.3.0] nonane is carried out as in the reaction of the crude hydroformylation product.

The process according to the invention allows a simple and inexpensive access to 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane in high yield and in high purity. The diamine produced by the process according to the invention can be used in an excellent manner for different applications, for example as a hardener for epoxy resins, as a component in polyurethanes and polyamides, and for the production of secondary products, which are used as additives in fuels and lubricants.

The method according to the invention will be explained in more detail below, but it is not limited to the described embodiments.

Examples Preparation of 3 (4), 7 (8) -bis (aminomethyl) bicyclo [4.3.0] nonane 1. Preparation of 3 (4), 7 (8) -bisformyl-bicyclo [4.3.0] nonane

In a steel autoclave with magnetic stirrer, 1000 g of bicyclo [4.3.0] nona-3,7-diene, technical grade, and 1000 g of toluene were submitted. After addition of 12.75 g of triphenylphosphine and 50 mg of Rh, in the form of a toluene solution of Rh-2-ethylhexanoate with a content of 7062 mg Rh / kg, the mixture was heated to 130 ° C and under a pressure of 26 MPa with Treated syngas. After a reaction time of 8 hours, the hydroformylation reaction was terminated.

The organic phase was analyzed by gas chromatography. GC analysis (area percent without toluene) light ends 0.2 [4.3.0] nona-3,7-dien-area 0.1 components 4.6 3 (4), 7 (8) -bisformylbicyclo [4.3.0] nonane 89.1 Triphenylphosphine / triphenylphosphine 1.2 high boiler 4.8

2. Preparation of 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane

The crude 3 (4), 7 (8) -bis-formyl-bicyclo [4.3.0] nonane obtained after the hydroformylation was substantially freed from toluene by distillation on a thin-film evaporator (jacket temperature 140 ° C., pressure 100 hPa). There was a residue which according to gas chromatographic analysis in addition to 6.7% toluene and 83.8% 3 (4), 7 (8) -Bisformyl-bicyclo [4.3.0] nonane still 9.5% components. The residue was then used in the reductive amination.

For this purpose, 380.3 g of n-butylamine were placed in a 2-l three-necked flask with stirrer and treated within 120 minutes at a temperature of 50 ° C with 477.5 g of distillation residue. The mixture was stirred for a further two hours at 50 ° C, then cooled and separated the resulting water phase (50.4 g) from the organic phase (807.4 g) (Schiff base).

805.0 g of the organic phase and 48.3 g of Ni 52/35 catalyst from Johnson-Matthey Plc were then placed in a 3 l autoclave. After pressurizing hydrogen up to a pressure of 1.5 MPa, 340.6 g of ammonia were pumped in. The mixture was then heated to 125 ° C and the pressure is adjusted to 10 MPa by further addition of hydrogen. The Schiff base formed from the reaction between 3 (4), 7 (8) -bis-formyl-bicyclo [4.3.0] nonane and n-butylamine was reacted under these conditions after 6 hours. After the reaction had ended, the mixture was cooled, vented and filtered off from the catalyst. The resulting reaction product was analyzed by gas chromatography. GC analysis (area percent) light ends 0.1% n-butylamine 36.2% Toluene / methylcyclohexane 3 (4), 7 (8) -bis (aminomethyl) - 4.5% [4.3.0] nonane 51.7% other 7.5%

For workup, 721.7 g of the crude 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane were distilled on a column with 4.5 theoretical plates. This gave 281.4 g of the main fraction in a boiling range of 148-149 ° C at a pressure of 5 hPa with the following composition. GC analysis (area percent) light ends <0.1% 3 (4), 7 (8) -bis (aminomethyl) bicyclo [4.3.0] nonane 99.3% other 0.7%

The overall yield of 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane is 73.0% of theory, based on bicyclo [4.3.0] nona-3, over all stages. 7-dien.

Characterization:

NMR data
¹ H-NMR (500 MHz, DMSO-d _6, ppm): 0.57 to 2.71 (m, 22 H, CH, CH ₂ and NH ₂₎
¹³ C-NMR (125 MHz, DMSO-d _6, ppm): 24.48 to 49.63 (CH and _CH2)
GC-MS (PCl): m / z = 365 {2M × H} ⁺ , 239 {M × C ₄ H ₉ } ⁺ , 183 {M × H} ⁺
IR data (diamond ATR-IR spectroscopy)
ν (cm ^-1 ): 3369 (w), 3287 (w), 2908 (s), 2852 (s), 1603 (m, br), 1446 (m), 807 (s, br)
Density at 20 ° C 0.9845 g / cm ³
Refractive index n _D at 20 ° C 1.5106

The process of the invention provides an elegant preparation route for 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane in high yields. The new compound 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane has an alicyclic ring structure with fused rings, which is outstandingly suitable as a hardener for epoxy resins or as a component for polyurethanes and polyamides. It can also be used to make secondary products used as additives in fuels and lubricants.

Claims (13)

Process for the preparation of 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane by hydroformylation of bicyclo [4.3.0] nona-3,7-diene with subsequent reductive amination, characterized in that bicyclo [4.3.0] nona-3,7-diene in homogeneous organic phase in the presence of complex-bonded organophosphorus compounds containing transition metal compounds of Group VIII of the Periodic Table of the Elements and excess organophosphorus compound at temperatures of 70 to 160 ° C and pressures of 5 reacted with synthesis gas to 35 MPa and the resulting 3 (4), 7 (8) -bisformyl-bicyclo [4.3.0] nonane then to 3 (4), 7 (8) -bis (aminomethyl) bicyclo [4.3. 0] nonane reductively aminated. A method according to claim 1, characterized in that is used as the organophosphorus organic phosphorus (III) compounds selected from the group of triarylphosphines, trialkylphosphines, alkylarylphosphines, alkyl phosphites, aryl phosphites, alkyl diphosphites or Aryldiphosphiten. A method according to claim 2, characterized in that is used as triarylphosphine triphenylphosphine and as aryl phosphite tris (2-tertiary-butylphenyl) phosphite or tris (2-tert-butyl-4-methylphenyl) phosphite. Process according to one or more of Claims 1 to 3, characterized in that, as transition metal compounds of Group VIII of the Periodic Table of the Elements, compounds of rhodium, Cobalt, iridium, nickel, palladium, platinum, iron or ruthenium. Process according to one or more of Claims 1 to 4, characterized in that compounds of rhodium are used as transition metal compounds of Group VIII of the Periodic Table of the Elements. Method according to one or more of claims 1 to 5, characterized in that one uses rhodium in a concentration of 5 to 1000 ppm by weight, based on the homogeneous reaction mixture. A method according to claim 6, characterized in that one uses rhodium in a concentration of 10 to 700 ppm by weight, preferably from 20 to 500 ppm by weight, based on the homogeneous reaction mixture. Process according to one or more of Claims 1 to 7, characterized in that the molar ratio of rhodium to phosphorus is 1: 5 to 1: 200. A method according to claim 8, characterized in that the molar ratio of rhodium to phosphorus is 1:10 to 1: 100. Method according to one or more of claims 1 to 9, characterized in that in the hydroformylation at temperatures of 80 to 150 ° C, preferably from 90 to 140 ° C, and at pressures of 10 to 30 MPa, preferably from 20 to 30 MPa, works. Method according to one or more of claims 1 to 10, characterized in that one carries out the reductive amination in the presence of nickel catalysts at temperatures of 60 to 150 ° C and at a hydrogen pressure of 2 to 12 MPa. Process according to Claim 11, characterized in that the diazomethine formed from 3 (4), 7 (8) -bis-formyl-bicyclo [4.3.0] nonane and a primary amine having 2 to 10 carbon atoms in the molecule is used for the reductive amination. The chemical compound 3 (4), 7 (8) -bis (aminomethyl) -bicyclo [4.3.0] nonane.