EP1808176A3 - 5 alpha reduced glucocorticoid metabolites for the treatment of inflammation - Google Patents
5 alpha reduced glucocorticoid metabolites for the treatment of inflammation Download PDFInfo
- Publication number
- EP1808176A3 EP1808176A3 EP07004317A EP07004317A EP1808176A3 EP 1808176 A3 EP1808176 A3 EP 1808176A3 EP 07004317 A EP07004317 A EP 07004317A EP 07004317 A EP07004317 A EP 07004317A EP 1808176 A3 EP1808176 A3 EP 1808176A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- treatment
- inflammation
- reduced glucocorticoid
- relates
- glucocorticoid metabolites
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003862 glucocorticoid Substances 0.000 title abstract 3
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 239000002207 metabolite Substances 0.000 title 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000005714 functional activity Effects 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 229940037128 systemic glucocorticoids Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0213745.3A GB0213745D0 (en) | 2002-06-14 | 2002-06-14 | Enzyme |
EP03760087A EP1515718A2 (en) | 2002-06-14 | 2003-06-16 | Modulation of activation of glucocorticoid receptors by breakdown products of glucocorticoids |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03760087.1 Division | 2003-06-16 | ||
EP03760087A Division EP1515718A2 (en) | 2002-06-14 | 2003-06-16 | Modulation of activation of glucocorticoid receptors by breakdown products of glucocorticoids |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1808176A2 EP1808176A2 (en) | 2007-07-18 |
EP1808176A3 true EP1808176A3 (en) | 2007-12-26 |
EP1808176B1 EP1808176B1 (en) | 2013-10-23 |
Family
ID=9938625
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07004317.9A Expired - Lifetime EP1808176B1 (en) | 2002-06-14 | 2003-06-16 | 5 alpha reduced glucocorticoid metabolites for the treatment of inflammation |
EP03760087A Withdrawn EP1515718A2 (en) | 2002-06-14 | 2003-06-16 | Modulation of activation of glucocorticoid receptors by breakdown products of glucocorticoids |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03760087A Withdrawn EP1515718A2 (en) | 2002-06-14 | 2003-06-16 | Modulation of activation of glucocorticoid receptors by breakdown products of glucocorticoids |
Country Status (6)
Country | Link |
---|---|
EP (2) | EP1808176B1 (en) |
JP (1) | JP2005533785A (en) |
AU (1) | AU2003250368A1 (en) |
CA (1) | CA2489312A1 (en) |
GB (3) | GB0213745D0 (en) |
WO (1) | WO2003105838A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7790706B2 (en) | 2002-06-14 | 2010-09-07 | The University Of Edinburgh | Treatment of inflammation with 5α reduced metabolites |
WO2005027901A1 (en) * | 2003-09-25 | 2005-03-31 | Tel Aviv University Future Technology Development L.P. | Compositions and methods using same for treating amyloid-associated diseases |
EP2305352A1 (en) * | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
PT3206692T (en) * | 2014-10-15 | 2024-04-30 | Corcept Therapeutics Inc | Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5358943A (en) * | 1987-12-29 | 1994-10-25 | Clark Abbot F | Use of tetrahydrocortisol to prevent elevations in intraocular pressure caused by corticosteroids |
WO2003059267A2 (en) * | 2001-12-21 | 2003-07-24 | Rhode Island Hospital | SELECTIVE 11β-HSD INHIBITORS AND METHODS FOR USE THEREOF |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
JPH0244454B2 (en) * | 1984-10-31 | 1990-10-04 | Kureha Chemical Ind Co Ltd | MENEKYOKUSEIBUTSUSHITSUJOKYOZAI |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
EP0318554B2 (en) | 1987-05-21 | 2005-01-12 | Micromet AG | Targeted multifunctional proteins |
IL91501A (en) | 1988-09-02 | 1998-03-10 | Dyax Corp | Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity |
AU634186B2 (en) | 1988-11-11 | 1993-02-18 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
AU732820B2 (en) | 1995-06-02 | 2001-05-03 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to growth factors |
US5547957A (en) * | 1993-10-15 | 1996-08-20 | Merck & Co., Inc. | Method of treating androgenic alopecia with 5-α reductase inhibitors |
JPH08259465A (en) * | 1995-03-27 | 1996-10-08 | Sekisui Chem Co Ltd | External preparation for treating skin desease |
JPH11513711A (en) * | 1995-10-23 | 1999-11-24 | メルク エンド カンパニー インコーポレーテッド | 17-alkyl-7-substituted-4-azasteroid derivatives |
US5939069A (en) * | 1996-08-23 | 1999-08-17 | University Of Florida | Materials and methods for detection and treatment of immune system dysfunctions |
AU8559598A (en) * | 1997-08-08 | 1999-03-01 | Ono Pharmaceutical Co. Ltd. | Gamma-type regulators for peroxisome proliferator-activated receptor |
AU1289899A (en) * | 1997-10-31 | 1999-05-24 | Arch Development Corporation | Methods and compositions for regulation of 5-alpha reductase activity |
WO1999036030A2 (en) * | 1998-01-16 | 1999-07-22 | Davitz, Michael, A. | Pharmaceutical composition and method for treating di-hydroxytestosterone dependent conditions |
FR2820636B1 (en) * | 2001-02-09 | 2007-10-05 | Laprophan Laboratoires De Prod | USE OF INDOMETACIN CALCIUM TO TREAT MEDIATED MEDIATION PATHOLOGIES OF CYCLO-OXYGENASE 2 |
CN1136887C (en) * | 2001-06-21 | 2004-02-04 | 贵州宏奇药业有限公司 | Exterior-applied medicine for treating dermatopathy |
-
2002
- 2002-06-14 GB GBGB0213745.3A patent/GB0213745D0/en not_active Ceased
-
2003
- 2003-06-16 JP JP2004512742A patent/JP2005533785A/en active Pending
- 2003-06-16 EP EP07004317.9A patent/EP1808176B1/en not_active Expired - Lifetime
- 2003-06-16 EP EP03760087A patent/EP1515718A2/en not_active Withdrawn
- 2003-06-16 WO PCT/GB2003/002597 patent/WO2003105838A2/en not_active Application Discontinuation
- 2003-06-16 CA CA002489312A patent/CA2489312A1/en not_active Abandoned
- 2003-06-16 AU AU2003250368A patent/AU2003250368A1/en not_active Abandoned
- 2003-06-16 GB GB0610137A patent/GB2426451A/en not_active Withdrawn
- 2003-06-16 GB GB0500686A patent/GB2407502A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5358943A (en) * | 1987-12-29 | 1994-10-25 | Clark Abbot F | Use of tetrahydrocortisol to prevent elevations in intraocular pressure caused by corticosteroids |
WO2003059267A2 (en) * | 2001-12-21 | 2003-07-24 | Rhode Island Hospital | SELECTIVE 11β-HSD INHIBITORS AND METHODS FOR USE THEREOF |
Non-Patent Citations (7)
Title |
---|
BERGER T S ET AL: "INTERACTION OF GLUCOCORTICOID ANALOGUES WITH THE HUMAN GLUCOCORTICOID RECEPTOR", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 41, no. 3-8, 1992, 10TH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, PARIS, pages 733 - 738, XP009024951, ISSN: 0960-0760 * |
COLVILLE-NASH PAUL R ET AL: "The pharmacological modulation of angiogenesis in chronic granulomatous inflammation", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 274, no. 3, 1995, pages 1463 - 1472, XP009024952, ISSN: 0022-3565 * |
DUBROVSKY B ET AL: "EFFECTS OF CORTICOSTERONE AND 5-ALPHA DIHYDROCORTICOSTERONE ON BRAIN EXCITABILITY IN THE RAT", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 14, no. 1, 1985, pages 117 - 128, XP009025027, ISSN: 0360-4012 * |
GOLF S W ET AL: "EFFECT OF 5-ALPHA DIHYDROCORTICOIDS ON ENZYMES OF GLUCONEOGENESIS IN RAT LIVER", STEROIDS, vol. 43, no. 1, 1984, pages 85 - 92, XP009025028, ISSN: 0039-128X * |
KOKATE TUSHAR G ET AL: "Anticonvulsant activity of neurosteroids: Correlation with gamma-aminobutyric acid-evoked chloride current potentiation", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 270, no. 3, 1994, pages 1223 - 1229, XP009025014, ISSN: 0022-3565 * |
LACKNER CAROLIN ET AL: "Glucocorticoid-recognizing and -effector sites in rat liver plasma membrane. Kinetics of corticosterone uptake by isolated membrane vesicles. III. Specificity and stereospecificity", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 64, no. 1-2, January 1998 (1998-01-01), pages 69 - 82, XP002435875, ISSN: 0960-0760 * |
TEICHER BEVERLY A ET AL: "Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 38, no. 2, 1996, pages 169 - 177, XP000973352, ISSN: 0344-5704 * |
Also Published As
Publication number | Publication date |
---|---|
EP1808176A2 (en) | 2007-07-18 |
GB2426451A (en) | 2006-11-29 |
GB0610137D0 (en) | 2006-06-28 |
WO2003105838A2 (en) | 2003-12-24 |
GB0213745D0 (en) | 2002-07-24 |
JP2005533785A (en) | 2005-11-10 |
CA2489312A1 (en) | 2003-12-24 |
GB2407502A (en) | 2005-05-04 |
EP1808176B1 (en) | 2013-10-23 |
GB0500686D0 (en) | 2005-02-23 |
AU2003250368A1 (en) | 2003-12-31 |
WO2003105838A3 (en) | 2004-05-06 |
EP1515718A2 (en) | 2005-03-23 |
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