EP1804795A4 - Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease - Google Patents

Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease

Info

Publication number
EP1804795A4
EP1804795A4 EP05800096A EP05800096A EP1804795A4 EP 1804795 A4 EP1804795 A4 EP 1804795A4 EP 05800096 A EP05800096 A EP 05800096A EP 05800096 A EP05800096 A EP 05800096A EP 1804795 A4 EP1804795 A4 EP 1804795A4
Authority
EP
European Patent Office
Prior art keywords
cicletanine
disease
agents
alone
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP05800096A
Other languages
German (de)
French (fr)
Other versions
EP1804795A2 (en
Inventor
Jim Page
Glenn Cornett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CORNETT GLEN
Original Assignee
CORNETT GLEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/035,231 external-priority patent/US20060154971A1/en
Priority claimed from US11/035,308 external-priority patent/US20060153934A1/en
Priority claimed from US11/035,328 external-priority patent/US20060154959A1/en
Priority claimed from US11/232,724 external-priority patent/US20060089374A1/en
Application filed by CORNETT GLEN filed Critical CORNETT GLEN
Publication of EP1804795A2 publication Critical patent/EP1804795A2/en
Publication of EP1804795A4 publication Critical patent/EP1804795A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP05800096A 2004-09-22 2005-09-22 Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease Ceased EP1804795A4 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US61232304P 2004-09-22 2004-09-22
US61236904P 2004-09-22 2004-09-22
US11/035,231 US20060154971A1 (en) 2005-01-13 2005-01-13 Combination therapies of cicletanine and lacidipine
US11/035,308 US20060153934A1 (en) 2005-01-13 2005-01-13 Combination therapies of cicletanine and magnesium
US11/035,328 US20060154959A1 (en) 2005-01-13 2005-01-13 Combination therapies of cicletanine and carvedilol
US68468405P 2005-05-26 2005-05-26
US11/232,724 US20060089374A1 (en) 2003-07-17 2005-09-21 Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
PCT/US2005/034763 WO2006034510A2 (en) 2004-09-22 2005-09-22 Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease

Publications (2)

Publication Number Publication Date
EP1804795A2 EP1804795A2 (en) 2007-07-11
EP1804795A4 true EP1804795A4 (en) 2007-11-07

Family

ID=36090724

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05800096A Ceased EP1804795A4 (en) 2004-09-22 2005-09-22 Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease

Country Status (3)

Country Link
EP (1) EP1804795A4 (en)
CA (1) CA2581337A1 (en)
WO (1) WO2006034510A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080096915A1 (en) * 2005-01-13 2008-04-24 Greenberg Traurig LLP Compositions for the treatment of metabolic disorders
KR101701943B1 (en) 2009-11-13 2017-02-02 도레이 카부시키가이샤 Therapeutic or prophylactic agent for diabetes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661147A (en) * 1993-09-03 1997-08-26 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinazoline derivatives
WO2004091612A1 (en) * 2003-04-15 2004-10-28 SynoSens Kutató és Fejlesztő Kft. A synergistic pharmaceutical combination comprising cicletanine for the prevention or treatment of diabetes
WO2005009446A1 (en) * 2003-07-17 2005-02-03 Cotherix, Inc. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
WO2005021039A1 (en) * 2003-08-29 2005-03-10 Cotherix, Inc. Combination of cicletanine and an oral antidiabetic and/or blood lipid-lowering agent for treating diabetes and metabolic syndrome

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN156817B (en) * 1981-02-10 1985-11-09 Scras

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661147A (en) * 1993-09-03 1997-08-26 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinazoline derivatives
WO2004091612A1 (en) * 2003-04-15 2004-10-28 SynoSens Kutató és Fejlesztő Kft. A synergistic pharmaceutical combination comprising cicletanine for the prevention or treatment of diabetes
WO2005009446A1 (en) * 2003-07-17 2005-02-03 Cotherix, Inc. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
WO2005021039A1 (en) * 2003-08-29 2005-03-10 Cotherix, Inc. Combination of cicletanine and an oral antidiabetic and/or blood lipid-lowering agent for treating diabetes and metabolic syndrome

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUCHHOLZ, R.A. ET AL.: "Natriuretic and diuretic effects of cicletanine in conscious, hydrated, normotensive rats", DRUG DEVELOPMENT RESEARCH, vol. 25, 1992, pages 125 - 137, XP002452886 *
KOHZUKI, M. ET AL.: "Renal-protective effect of nondepressor dose of cicletanine in diabetic rats with hypertension", AMERICAN JOURNAL OF HYPERTENSION, vol. 13, 2000, pages 298 - 306, XP002452885 *
PASSA, P.: "Etude de la tolérance du ciclétanine chez des patients hypertendus présentant des troubles métaboliques", ARCH MAL COEUR, vol. 824, 1989, pages 135 - 138, XP009090138 *

Also Published As

Publication number Publication date
WO2006034510A2 (en) 2006-03-30
EP1804795A2 (en) 2007-07-11
CA2581337A1 (en) 2006-03-30
WO2006034510A3 (en) 2006-06-01

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20070420

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CORNETT, GLENN

Inventor name: PAGE, JIM

A4 Supplementary search report drawn up and despatched

Effective date: 20071010

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 3/00 20060101ALI20071001BHEP

Ipc: A61P 9/12 20060101ALI20071001BHEP

Ipc: A01N 25/00 20060101ALI20071001BHEP

Ipc: A61K 31/4355 20060101AFI20071001BHEP

DAX Request for extension of the european patent (deleted)
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Effective date: 20090929

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