EP1766073A4 - Verbesserte proteinexpression - Google Patents
Verbesserte proteinexpressionInfo
- Publication number
- EP1766073A4 EP1766073A4 EP05758747A EP05758747A EP1766073A4 EP 1766073 A4 EP1766073 A4 EP 1766073A4 EP 05758747 A EP05758747 A EP 05758747A EP 05758747 A EP05758747 A EP 05758747A EP 1766073 A4 EP1766073 A4 EP 1766073A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- protein expression
- enhancing protein
- enhancing
- expression
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57681904P | 2004-06-04 | 2004-06-04 | |
PCT/US2005/019592 WO2005118874A1 (en) | 2004-06-04 | 2005-06-06 | Enhancing protein expression |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1766073A1 EP1766073A1 (de) | 2007-03-28 |
EP1766073A4 true EP1766073A4 (de) | 2007-08-01 |
Family
ID=35462920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05758747A Withdrawn EP1766073A4 (de) | 2004-06-04 | 2005-06-06 | Verbesserte proteinexpression |
Country Status (5)
Country | Link |
---|---|
US (1) | US20090069256A1 (de) |
EP (1) | EP1766073A4 (de) |
AU (1) | AU2005250477A1 (de) |
CA (1) | CA2567116A1 (de) |
WO (1) | WO2005118874A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007207785B2 (en) * | 2006-01-13 | 2013-11-14 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Codon optimized IL- 15 and IL- 15R-alpha genes for expression in mammalian cells |
ATE533782T1 (de) | 2006-01-13 | 2011-12-15 | Univ Pennsylvania | Impfstoffe und immuntherapeutika mit codon- optimiertem il-15 und verwendungsverfahren dafür |
AU2013203171B2 (en) * | 2006-01-13 | 2016-05-19 | The Government of the United States, as represented by The Secretary, Department of Health and Human Services, National Institutes of Health | Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells |
WO2007084364A2 (en) * | 2006-01-13 | 2007-07-26 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health | Improved il-12 for expression in mammalian cells |
GB0909689D0 (en) * | 2009-06-05 | 2009-07-22 | Trinity College Dublin | Fluorescent proteins |
WO2012040101A1 (en) | 2010-09-21 | 2012-03-29 | University Of Miami | Compositions and methods for inducing migration by dendritic cells and an immune response |
WO2012040266A2 (en) * | 2010-09-24 | 2012-03-29 | University Of Miami | Gene-based adjuvants and compositions thereof to increase antibody production in response to gene-based vaccines |
CN105142676B (zh) | 2013-03-14 | 2022-06-28 | 夏尔人类遗传性治疗公司 | Cftr mrna组合物以及相关方法和用途 |
WO2014145038A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Vaccines with biomolecular adjuvants |
KR20230122181A (ko) | 2013-11-29 | 2023-08-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신 |
US20210244795A1 (en) * | 2018-06-11 | 2021-08-12 | The Wistar Institute Of Anatomy And Biology | Compositions and methods for in vivo post translational modification |
CA3127645A1 (en) * | 2019-01-30 | 2020-08-06 | The Wistar Institute Of Anatomy And Biology | Dna-encoded bispecific t-cell engagers targeting cancer antigens and methods of use in cancer theraputics |
WO2023235805A2 (en) * | 2022-06-01 | 2023-12-07 | The Wistar Institute Of Anatomy And Biology | Dna-encoded bispecific antibodies targeting carbonic anhydrase 9 and methods of use in cancer therapeutics |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002029088A2 (en) * | 2000-10-04 | 2002-04-11 | The Trustees Of The University Of Pennsylvania | Highly expressible genes |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6174666B1 (en) * | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
US5795737A (en) * | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
US5786464C1 (en) * | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
-
2005
- 2005-06-06 US US11/628,455 patent/US20090069256A1/en not_active Abandoned
- 2005-06-06 CA CA002567116A patent/CA2567116A1/en not_active Abandoned
- 2005-06-06 WO PCT/US2005/019592 patent/WO2005118874A1/en active Application Filing
- 2005-06-06 EP EP05758747A patent/EP1766073A4/de not_active Withdrawn
- 2005-06-06 AU AU2005250477A patent/AU2005250477A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002029088A2 (en) * | 2000-10-04 | 2002-04-11 | The Trustees Of The University Of Pennsylvania | Highly expressible genes |
Non-Patent Citations (4)
Title |
---|
HAAS J ET AL: "CODON USAGE LIMITATION IN THE EXPRESSION OF HIV-1 ENVELOPE GLYCOPROTEIN", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 6, no. 3, 1 March 1996 (1996-03-01), pages 315 - 324, XP000619599, ISSN: 0960-9822 * |
MILLAND JULIE ET AL: "Translation is enhanced after silent nucleotide substitutions in A+T-rich sequences of the coding region of CD46 cDNA", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 238, no. 1, 1996, pages 221 - 230 * |
See also references of WO2005118874A1 * |
ZOLOTUKHIN S ET AL: "A HUMANIZED GREEN FLUORESCENT PROTEIN CDNA ADAPTED FOR HIGH-LEVEL EXPRESSION IN MAMMALIAN CELLS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 70, no. 7, July 1996 (1996-07-01), pages 4646 - 4654, XP002030427, ISSN: 0022-538X * |
Also Published As
Publication number | Publication date |
---|---|
CA2567116A1 (en) | 2005-12-15 |
AU2005250477A1 (en) | 2005-12-15 |
EP1766073A1 (de) | 2007-03-28 |
WO2005118874A9 (en) | 2006-03-16 |
WO2005118874A1 (en) | 2005-12-15 |
US20090069256A1 (en) | 2009-03-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20061222 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SHAHABI, VAFA Inventor name: SMITH, LARRY, RUSSELL Inventor name: SIDHU, MANINDER, K. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20070629 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 48/00 20060101ALI20070626BHEP Ipc: C12N 15/63 20060101ALI20070626BHEP Ipc: C12N 15/67 20060101AFI20070626BHEP |
|
DAX | Request for extension of the european patent (deleted) | ||
17Q | First examination report despatched |
Effective date: 20070827 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20090512 |