EP1756297A4 - High throughput reactive oxygen species-based cytochrome p450 inhibition assay - Google Patents

High throughput reactive oxygen species-based cytochrome p450 inhibition assay

Info

Publication number
EP1756297A4
EP1756297A4 EP05733259A EP05733259A EP1756297A4 EP 1756297 A4 EP1756297 A4 EP 1756297A4 EP 05733259 A EP05733259 A EP 05733259A EP 05733259 A EP05733259 A EP 05733259A EP 1756297 A4 EP1756297 A4 EP 1756297A4
Authority
EP
European Patent Office
Prior art keywords
high throughput
oxygen species
reactive oxygen
inhibition assay
cytochrome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05733259A
Other languages
German (de)
French (fr)
Other versions
EP1756297A2 (en
Inventor
Dhiren R Thakker
John H Ansede
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Publication of EP1756297A2 publication Critical patent/EP1756297A2/en
Publication of EP1756297A4 publication Critical patent/EP1756297A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP05733259A 2004-04-05 2005-04-05 High throughput reactive oxygen species-based cytochrome p450 inhibition assay Withdrawn EP1756297A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55957004P 2004-04-05 2004-04-05
PCT/US2005/011551 WO2005098025A2 (en) 2004-04-05 2005-04-05 High throughput reactive oxygen species-based cytochrome p450 inhibition assay

Publications (2)

Publication Number Publication Date
EP1756297A2 EP1756297A2 (en) 2007-02-28
EP1756297A4 true EP1756297A4 (en) 2008-05-21

Family

ID=35125680

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05733259A Withdrawn EP1756297A4 (en) 2004-04-05 2005-04-05 High throughput reactive oxygen species-based cytochrome p450 inhibition assay

Country Status (3)

Country Link
EP (1) EP1756297A4 (en)
JP (1) JP2007531538A (en)
WO (1) WO2005098025A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629140B2 (en) * 2004-10-07 2009-12-08 Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.P.A. Assay for cytochrome P450 isoform 2C9

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034506A2 (en) * 1998-12-04 2000-06-15 University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to oxidative metabolism

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20023357D0 (en) * 2002-04-19 2002-07-11 Amersham Health As Mixture
NO20023358D0 (en) * 2002-04-19 2002-07-11 Amersham Health As Method
WO2004004702A2 (en) * 2002-07-09 2004-01-15 The Scripps Research Institute Method to inhibit ischemia and reperfusion injury

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034506A2 (en) * 1998-12-04 2000-06-15 University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to oxidative metabolism

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FERRER A S ET AL: "FLUORESCENCE DETECTION OF ENZYMATICALLY FORMED HYDROGEN PEROXIDE INAQUEOUS SOLUTION AND IN REVERSED MICELLES", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 187, 1990, pages 129 - 132, XP000920918, ISSN: 0003-2697 *
SHERTZER HOWARD G ET AL: "Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes.", FREE RADICAL BIOLOGY & MEDICINE, vol. 36, no. 5, 1 March 2004 (2004-03-01), pages 618 - 631, XP002461880, ISSN: 0891-5849 *

Also Published As

Publication number Publication date
WO2005098025A2 (en) 2005-10-20
JP2007531538A (en) 2007-11-08
EP1756297A2 (en) 2007-02-28
WO2005098025A3 (en) 2006-03-23

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20061106

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DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20080423

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/26 20060101AFI20051025BHEP

Ipc: G01N 33/15 20060101ALI20080414BHEP

Ipc: G01N 33/50 20060101ALI20080414BHEP

STAA Information on the status of an ep patent application or granted ep patent

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Effective date: 20080724