EP1744787A4 - Polymeric coupling agents and pharmaceutically-active polymers made therefrom - Google Patents

Polymeric coupling agents and pharmaceutically-active polymers made therefrom

Info

Publication number
EP1744787A4
EP1744787A4 EP05746912A EP05746912A EP1744787A4 EP 1744787 A4 EP1744787 A4 EP 1744787A4 EP 05746912 A EP05746912 A EP 05746912A EP 05746912 A EP05746912 A EP 05746912A EP 1744787 A4 EP1744787 A4 EP 1744787A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutically
coupling agents
made therefrom
polymers made
active polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05746912A
Other languages
German (de)
French (fr)
Other versions
EP1744787A1 (en
Inventor
Paul J Santerre
Frank J Laronde
Mei Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interface Biologics Inc
Original Assignee
Interface Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002467321A external-priority patent/CA2467321A1/en
Application filed by Interface Biologics Inc filed Critical Interface Biologics Inc
Priority to EP15163241.1A priority Critical patent/EP2939695B1/en
Publication of EP1744787A1 publication Critical patent/EP1744787A1/en
Publication of EP1744787A4 publication Critical patent/EP1744787A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
EP05746912A 2004-05-14 2005-05-13 Polymeric coupling agents and pharmaceutically-active polymers made therefrom Withdrawn EP1744787A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15163241.1A EP2939695B1 (en) 2004-05-14 2005-05-13 Polymeric coupling agents and pharmaceutically-active polymers made therefrom

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA002467321A CA2467321A1 (en) 2004-05-14 2004-05-14 Polymeric coupling agents and pharmaceutically-active polymers made therefrom
US10/875,550 US20050255079A1 (en) 2004-05-14 2004-06-25 Polymeric coupling agents and pharmaceutically-active polymers made therefrom
PCT/CA2005/000742 WO2005110485A1 (en) 2004-05-14 2005-05-13 Polymeric coupling agents and pharmaceutically-active polymers made therefrom

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP15163241.1A Division EP2939695B1 (en) 2004-05-14 2005-05-13 Polymeric coupling agents and pharmaceutically-active polymers made therefrom

Publications (2)

Publication Number Publication Date
EP1744787A1 EP1744787A1 (en) 2007-01-24
EP1744787A4 true EP1744787A4 (en) 2011-04-06

Family

ID=35393999

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05746912A Withdrawn EP1744787A4 (en) 2004-05-14 2005-05-13 Polymeric coupling agents and pharmaceutically-active polymers made therefrom

Country Status (4)

Country Link
EP (1) EP1744787A4 (en)
JP (1) JP5247144B2 (en)
AU (1) AU2005244037A1 (en)
WO (1) WO2005110485A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2620175C (en) * 2005-08-22 2013-04-30 Quick-Med Technologies, Inc. Disinfectant with quaternary ammonium polymers and copolymers
WO2007148230A2 (en) * 2006-04-14 2007-12-27 Interface Biologics Incorporated Grafted polymers and uses thereof
CA2656112A1 (en) * 2006-06-30 2008-05-08 Hanje Chen Bioresponsive polymers
WO2009124386A1 (en) * 2008-04-07 2009-10-15 Interface Biologics Inc. Combination therapy for the treatment of bacterial infections
US8440176B2 (en) 2008-04-25 2013-05-14 Interface Biologics, Inc. Covalently grafted pharmaceutically active polymers
EP3357522B1 (en) * 2013-03-15 2019-10-16 Interface Biologics Inc. Coated medical article for drug release
JP2021512852A (en) 2018-02-02 2021-05-20 リップル セラピューティクス コーポレーション Glass preparation containing steroid dimer and its use
EP4146664A2 (en) 2020-05-01 2023-03-15 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012990A1 (en) * 1997-09-10 1999-03-18 Rutgers, The State University Polyanhydrides with therapeutically useful degradation products

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
AU705101B2 (en) * 1996-02-15 1999-05-13 Interface Biologics Inc. Bioresponsive pharmacologically-active polymers and articles made therefrom
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
WO2002009768A2 (en) * 2000-07-27 2002-02-07 Rutgers, The State University Therapeutic polyesters and polyamides
US6602915B2 (en) * 2000-07-27 2003-08-05 Rutgers, The State University Of New Jersey Therapeutic azo-compounds for drug delivery
US20030158598A1 (en) * 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
US7326685B2 (en) * 2001-09-21 2008-02-05 The Administrators Of The Tulane Educational Fund Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
WO2003043657A1 (en) * 2001-11-19 2003-05-30 Control Delivery Systems, Inc. Topical delivery of codrugs
EP1542664A4 (en) * 2002-08-14 2008-04-16 Med College Georgia Res Inst Methods and compositions for treatment of macular and retinal disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012990A1 (en) * 1997-09-10 1999-03-18 Rutgers, The State University Polyanhydrides with therapeutically useful degradation products

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUDAVARI S (EDITOR): "THE MERCK INDEX - TWELFTH EDITION", 1 January 1996, MERCK RESEARCH LABORATORIES, Whitehouse Station, NJ, USA, ISBN: 091 1910-12-3, pages: 1305, XP002624238 *
J CHIRIFE ET AL: "In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 24, no. 3, 1 September 1983 (1983-09-01), pages 409 - 412, XP055128830, ISSN: 0066-4804, DOI: 10.1128/AAC.24.3.409 *
See also references of WO2005110485A1 *

Also Published As

Publication number Publication date
EP1744787A1 (en) 2007-01-24
AU2005244037A1 (en) 2005-11-24
JP5247144B2 (en) 2013-07-24
JP2007537168A (en) 2007-12-20
WO2005110485A1 (en) 2005-11-24

Similar Documents

Publication Publication Date Title
GB2436775B (en) Polymer compound and device using the same
IL172094A0 (en) Polymeric conjugates and methods for the preparation thereof
EP1719794A4 (en) Novel polymers and uses thereof
GB2435194B (en) Polymer material and device using the same
EP1608688A4 (en) Branched water-soluble polymers and their conjugates
PL1756221T3 (en) Polymeric materials and additives therefor
IL183582A0 (en) Polymer conjugates and methods for the preparation thereof
EP1781709A4 (en) Superabsorbent polymers in agricultural applications
IL182405A0 (en) Mouldable biodegradable polymer
EP1744787A4 (en) Polymeric coupling agents and pharmaceutically-active polymers made therefrom
EP1824467A4 (en) Apogossypolone and the uses thereof
EP1731540A4 (en) Polymer particle
EP1734988A4 (en) Interferon-beta polymer conjugates
GB0504862D0 (en) Polymeric void-board
GB2434584B (en) Solution composition and polymer light-emitting device
BRPI0513872A (en) polymeric composition and shaped article
EP1976546A4 (en) Cyclodextrin-containing polymers and uses thereof
AU2003241279A8 (en) Antimicrobial polymer conjugates
GB2436758B (en) Salicylate substituted conjugated polymers and devices
GB0423212D0 (en) Polymer
EP1761256A4 (en) Cla-enriched milkfat and uses thereof
GB0420893D0 (en) Photosensitisers and their uses
ZA200803627B (en) Polymers incorporating 1,3 and 1,4 cyclohexnedimethanol
GB0424811D0 (en) Polymeric materials
EP1741740A4 (en) Polymer having oxocarbon group and use thereof

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20061123

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20110309

RIC1 Information provided on ipc code assigned before grant

Ipc: A61L 27/54 20060101ALI20110301BHEP

Ipc: A61K 47/48 20060101AFI20051201BHEP

17Q First examination report despatched

Effective date: 20111121

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20150414