EP1716256A2 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis - Google Patents

Abstract

Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.

Description

Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of use thereof for

Diagnosis

FIELD QF THE INVENTION

The present invention is related to novel nucleotide sequences that are useful as diagnostic markers, and assays and methods of use thereof.

BACKGROUND OF THE INVENTION Nucleic Acid Testing (NAT) is a subset of molecular diagnostic markers, based on testing for the presence of a nucleic acid sequence in a sample, associated with a certain condition (most often a clinical pathology). The sample could be a body fluid, a tissue sample, a body secretion or any other sample obtained from a patient which could contain the targeted nucleic acids. Traditionally, NAT diagnosis has been used for the diagnosis of infectious diseases.

Particularly, it has been used for the diagnosis of HIV, Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), Chlamydia trachomatis, Neisseria gonorrhoeae and Mycobacteria tuberculosis. In recent years NAT diagnosis has expanded to noninfectious diseases, for example, for the diagnosis of prostate cancer based on DD3 (PCA3). DD3 (PCA3) is a very prostate cancer- specific gene. It has shown a great diagnostic value for prostate cancer by measuring quantitavely the DD3 (PCA3) transcript in urine sediments obtained after prostatic massage. DD3( PCA3) is a non-coding transcript, therefore diagnosis in the protein level is not possible. More NAT markers for more cancers in addition to prostate cancer are currently pursued. NAT diagnostic markers have at least four advantages on protein based diagnostic modalities:

1. They are likely to be more sensitive and specific (as has been shown for diagnostic kits for HIV and HCV). This finding could be related to at least two things: a. The test analyte could be amplified (e.g. with PCR) b. The detection method is sequence specific rather than epitope specific 2. They allow diagnosis even if a differentially expressed transcript is non-coding (as in the case of DD3(PCA3))

3. The research tools for the discovery of novel NAT markers are much more advanced and robust than for protein markers (e.g. advanced DNA chip technology compared with protein chip technology)

4. NAT analytes are sometimes found in body secretions and/or body fluids and therefore could replace the need for a tissue biopsy when a serum marker is not available.

However, NAT markers suffer from a few disadvantages including: 1. The analyte itself is quite an unstable molecule (certainly when compared with a protein). 2. The analyte itself is by nature not physiologically secreted, therefore it is not always easily found in samples.

NAT markers development for noninfectious diseases was not pursued for a long time, which was mostly a result of expensive and not fully developed detection methods on one hand and intellectual property barriers on the other. With the advance in technology and expiration of key patents in the field, the industry is investing more and more resources in that direction and it seems that NAT based tests are going to be much more prevalent for noninfectious diseases in the future.

SUMMARY OF THE INVENTION

The present invention overcomes deficiencies of the background art by providing novel variants that are suitable for use with NAT and/or nucleic acid hybridization methods and assays, which may optionally be used as diagnostic markers. Collectively, methods and assays that are suitable for detecting a nucleic acid sequence (oligonucleotides) are referred to herein as "oligonucleotide detection technologies", including but not limited to NAT and hybridization technologies. The markers of the present invention may optionally be used with any such oligonucleotide detection technology. The markers are useful for detecting variant-detectable diseases (marker- detectable diseases), wherein these diseases and/or pathological states and/or conditions are described in greater detail below with regard to the different clusters (genes) below.

Preferably these variants are useful as diagnostic markers for variant-detectable diseases. According to one embodiment of the present invention markers are specifically released to the bloodstream under disease conditions according to one of the above differential variant marker conditions.

The present invention therefore also relates to diagnostic assays for disease detection optionally and preferably in a sample taken from a subject (patient), which is more preferably some type of blood sample or body secretion sample. The assays are optionally NAT (nucleic acid amplification technology) -based assays, such as PCR for example (or variations thereof such as real-time PCR for example). The assays may also optionally encompass nucleic acid hybridization assays. The assays may optionally be qualitative or quantitative.

The present invention also relates to kits based upon such diagnostic methods or assays. In certain embodiments, the sample taken from the subject can be selected from one or more of blood, serum, plasma, blood cells, urine, sputum, saliva, stool, spinal fluid, lymph fluid, the external sections of the skin, respiratory, intestinal, and genitourinary tracts, tears, milk, neuronal tissue, pleural fluid, peritoneal fluid, cyst fluid, including ovarian cyst fluid, and any human organ and tissue. In another embodiment, this invention provides an isolated nucleic acid molecule encoding for a splice variant according to the present invention, having a nucleotide sequence as set forth in any one of the sequences listed herein, or a sequence complementary thereto. In another embodiment, this invention provides an isolated nucleic acid molecule, having a nucleotide sequence as set forth in any one of the sequences listed herein, or a sequence complementary thereto. In another embodiment, this invention provides an oligonucleotide of at least about 12 nucleotides, specifically hybridizable with the nucleic acid molecules of this invention. In another embodiment, this invention provides vectors, cells, liposomes and compositions comprising the isolated nucleic acids of this invention.

In another embodiment, this invention provides a method for detecting a splice variant nucleic acid sequence in a biological sample, comprising: hybridizing the isolated nucleic acid molecules or oligonucleotide fragments of at least about 12 nucleotides thereof to a nucleic acid material of a biological sample and detecting a hybridization complex; wherein the presence of a hybridization complex correlates with the presence of a splice variant nucleic acid sequence in the biological sample. According to the present invention, the splice variant nucleic acid sequences described herein are non- limiting examples of markers for diagnosing the below described disease condition(s). Each splice variant nucleic acid sequence marker of the present invention can be used alone or in combination, for various uses, including but not limited to, prognosis, prediction, screening, early diagnosis, determination of progression, therapy selection and treatment monitoring of one of the above-described diseases.

According to optional but preferred embodiments of the present invention, any marker according to the present invention may optionally be used alone or combination. Such a combination may optionally comprise a plurality of markers described herein, optionally including any subcombination of markers, and/or a combination featuring at least one other marker, for example a known marker. Furthermore, such a combination may optionally and preferably be used as described above with regard to determining a ratio between a quantitative or semi-quantitative measurement of any marker described herein to any other marker described herein, and/or any other known marker, and/or any other marker. With regard to such a ratio between any marker described herein (or a combination thereof) and a known marker, more preferably the known marker comprises the "known protein" as described in greater detail below with regard to each cluster or gene.

Although optionally any method may be used to detect the presence (for example in the blood) and/or differential expression of this marker, optionally a NAT-based technology is used. Therefore, optionally and preferably, any nucleic acid molecule capable of selectively hybridizing to a nucleic acid of a splice variant marker as previously defined is also encompassed within the present invention.

According to other preferred embodiments of the present invention, a splice variant nucleic acid sequence or a fragment thereof, may be featured as a biomarker for detecting a variant-detectable disease, such that a biomarker may optionally comprise any of the above. According to still other preferred embodiments, the present invention optionally and preferably encompasses any amino acid sequence or fragment thereof encoded by a nucleic acid sequence as described herein. The present invention also optionally and preferably encompasses any nucleic acid sequence or fragment thereof, or amino acid sequence or fragment thereof, corresponding to a splice variant nucleic acid sequence of the present invention as described above, optionally for any application.

According to still other optional but preferred embodiments of the present invention, a variant according to the present invention may be a marker for one or more of the diseases and/or pathologies as described above. Information is given in the text with regard to SNPs (single nucleotide polymorphisms).

A description of the abbreviations is as follows. "T - > C", for example, means that the SNP results in a change at the position given in the table from T to C. Similarly, "M - > Q", for example, means that the SNP has caused a change in the corresponding amino acid sequence, from methionine (M) to glutamine (Q). If, in place of a letter at the right hand side for the nucleotide sequence SNP, there is a space, it indicates that a frameshift has occurred. A frameshift may also be indicated with a hyphen (-). A stop codon is indicated with an asterisk at the right hand side (*). As part of the description of an SNP, a comment may be found in parentheses after the above description of the SNP itself. This comment may include an FTId, which is an identifier to a SwissProt entry that was created with the indicated SNP. An FTId is a unique and stable feature identifier, which allows to construct links directly from position- specific annotation in the feature table to specialized protein-related databases. The FTId is always the last component of a feature in the description field, as follows: FTId=XXX_number, in which XXX is the 3- letter code for the specific feature key, separated by an underscore from a 6- digit number.

Information is given with regard to overexpression of a cluster in cancer based on ESTs. A key to the p values with regard to the analysis of such overexpression is as follows:

- library-based statistics: P- value without including the level of expression in cell- lines (Pl) - library based statistics: P-value including the level of expression in cell- lines (P2) - EST clone statistics: P- value without including the level of expression in cell- lines (SPl)

- EST clone statistics: predicted overexpression ratio without including the level of expression in cell- lines (R3) - EST clone statistics: P- value including the level of expression in cell- lines (SP2)

- EST clone statistics: predicted overexpression ratio including the level of expression in cell- lines (R4)

Library-based statistics refer to statistics over an entire library, while EST clone statistics refer to expression only for ESTs from a particular tissue or cancer.

Information is given with regard to overexpression of a cluster in cancer based on microarrays. As a microarray reference, in the specific segment paragraphs, the unabbreviated tissue name was used as the reference to the type of chip for which expression was measured. The microarray fabrication procedure is described in detail in Materials and Experimental Procedures section herein.

The following list of abbreviations for tissues was used in the TAA histograms. The term "TAA" stands for "Tumor Associated Antigen", and the TAA histograms, given in the text, represent the cancerous tissue expression pattern as predicted by the biomarkers selection engine, as described in detail in examples 1-5 below: "BONE" for "bone";

"COL" for "colon";

"EPI" for "epithelial";

"GEN" for "general";

"LIVER" for "liver"; "LUN" for "lung";

"LYMPH" for "lymph nodes";

"MARROW" for "bone marrow";

"OVA" for "ovary";

"PANCREAS" for "pancreas"; "PRO" for "prostate";

"STOMACH" for "stomach";

"TCELL" for "T cells";

"THYROID" for "Thyroid";

"MAM" for "breast"; "BRAIN" for "brain";

"UTERUS" for "uterus"; "SKIN" for "skin"; "KIDNEY" for "kidney"; "MUSCLE" for "muscle"; "ADREN" for "adrenal"; "HEAD" for "head and neck";

"BLADDER" for "bladder";

It should be noted that the terms "segment", "seg" and "node" are used interchangeably in reference to nucleic acid sequences of the present invention; they refer to portions of nucleic acid sequences that were shown to have one or more properties as described below. They are also the building blocks that were used to construct complete nucleic acid sequences as described in greater detail below.Unless defined otherwise, all technical and scientific terms used herein have the meaning commonly understood by a person skilled in the art to which this invention belongs. The following references provide one of skill with a general definition of many of the terms used in this invention: Singleton et al., Dictionary of Microbiology and Molecular Biology (2nd ed. 1994); The Cambridge Dictionary of Science and Technology (Walker ed., 1988); The Glossary of Genetics, 5th Ed., R. Rieger et al. (eds.), Springer Verlag (1991); and Hale & Marham, The Harper Collins Dictionary of Biology (1991). All of these are hereby incorporated by reference as if fully set forth herein. As used herein, the following terms have the meanings ascribed to them unless specified otherwise.

Assays, terms and definitions

As used herein the phrase "disease" includes any type of pathology and/or damage, including both chronic and acute damage, as well as a progress from acute to chronic damage. The term "marker" in the context of the present invention refers to a nucleic acid fragment, which is differentially present in a sample taken from patients having one of the above- described diseases or conditions, as compared to a comparable sampb taken from subjects who do not have one the above-described diseases or conditions.

The phrase "differentially present" refers to differences in the quantity of a marker present in a sample taken from patients having one of the above- described diseases or conditions as compared to a comparable sample taken from patients who do not have one of the above- described diseases or conditions. For example, a nucleic acid fragment may optionally be differentially present between the two samples if the amount of the nucleic acid fragment in one sample is significantly different from the amount of the nucleic acid fragment in the other sample, for example as measured by hybridization and/or NAT-based assays. It should be noted that if the marker is detectable in one sample and not detectable in the other, then such a marker can be considered to be differentially present. Optionally, a relatively low amount of up- regulation may serve as the marker, as described above. One of ordinary skill in the art could easily determine such relative levels of the markers; further guidance is provided in the description of each individual marker below.

The term "diagnostic" means identifying the presence or nature of a pathologic condition. Diagnostic methods differ in their sensitivity and specificity. The "sensitivity" of a diagnostic assay is the percentage of diseased individuals who test positive (percent of "true positives"). Diseased individuals not detected by the assay are "false negatives." Subjects who are not diseased and who test negative in the assay are termed "true negatives." The "specificity" of a diagnostic assay is 1 minus the false positive rate, where the "false positive" rate is defined as the proportion of those without the disease who test positive. While a particular diagnostic method may not provide a definitive diagnosis of a condition, it suffices if the method provides a positive indication that aids in diagnosis.

As used herein the term "diagnosing" refers to classifying a disease or a symptom, determining a severity of the disease, monitoring disease progression, forecasting an outcome of a disease and/or prospects of recovery. The term "detecting" may also optionally encompass any of the above.

Diagnosis of a disease according to the present invention can be effected by determining a level of a polynucleotide of the present invention in a biological sample obtained from the subject, wherein the level determined can be correlated with predisposition to, or presence or absence of the disease. As used herein, the term "level" refers to expression levels of RNA or to DNA copy number of a marker of the present invention.

Typically the level of the marker in a biological sample obtained from the subject is different (i.e., increased or decreased) from the level of the same variant in a similar sample obtained from a healthy individual. As used herein "a biological sample" refers to a sample of tissue or fluid isolated from a subject, including but not limited to, for example, plasma, serum, spinal fluid, lymph fluid, the external sections of the skin, respiratory, intestinal, and genitourinary tracts, tears, saliva, sputum, milk, whole blood or any blood fraction, blood cells, tumors, neuronal tissue, organs or any other types of tissue, any sample obtained by lavage (for example of the bronchial system), and also samples of in vivo cell culture constituents. Numerous well known tissue or fluid collection methods can be utilized to collect the biological sample from the subject in order to determine the level of DNA, RNA and/or polypeptide of the variant of interest in the subject.

Examples include, but are not limited to, fine needle biopsy, needle biopsy, core needle biopsy and surgical biopsy (e.g., brain biopsy), and lavage. Regardless of the procedure employed, once a biopsy/sample is obtained the level of the variant can be determined and a diagnosis can thus be made.

Determining the level of the same variant in normal tissues of the same origin is preferably effected along-side to detect an elevated expression and/or amplification, and/or a decreased expression, of the variant as opposed to the normal tissues. A "test amount" of a marker refers to an amount of a marker present in a sample being tested. A test amount can be either in absolute amount (e.g., microgram/ml) or a relative amount (e.g., relative intensity of signals).

A "diagnostic amount" of a marker refers to an amount of a marker in a subject's sample that is consistent with a diagnosis of a variant- detectable disease. A diagnostic amount can be either in absolute amount (e.g., microgram/ml) or a relative amount (e.g., relative intensity of signals).

A "control amount" of a marker can be any amount or a range of amounts to be compared against a test amount of a marker. For example, a control amount of a marker can be the amount of a marker in a patient with variant- detectable disease or a person without variant - detectable disease. A control amount can be either in absolute amount (e.g., microgram/ml) or a relative amount (e.g., relative intensity of signals).

"Substrate" refers to a solid phase onto which an adsorbent can be provided (e.g., by attachment, deposition, etc.)

"Adsorbent" refers to any material capable of adsorbing a marker. The term "adsorbent" is used herein to refer both to a single material ("monoplex adsorbent") (e.g., a compound or functional group) to which the marker is exposed, and to a plurality of different materials ("multiplex adsorbent") to which the marker is exposed. The adsorbent materials in a multiplex adsorbent are referred to as "adsorbent species." For example, an addressable location on a probe substrate can comprise a multiplex adsorbent characterized by many different adsorbent species (e.g., anion exchange materials, metal chelators, or antibodies), having different binding characteristics. Substrate material itself can also contribute to adsorbing a marker and may be considered part of an "adsorbent."

"Adsorption" or "retention" refers to the detectable binding between an absorbent and a marker either before or after washing with an eluant (selectivity threshold modifier) or a washing solution.

"Eluant" or "washing solution" refers to an agent that can be used to mediate adsoiption of a marker to an adsorbent. Eluants and washing solutions can be used to wash and remove unbound materials from the probe substrate surface.

"Detect" refers to identifying the presence, absence or amount of the object to be detected.

"Detectable moiety" or a "label" refers to a composition detectable by spectroscopic, photo chemical, biochemical, immunochemical, or chemical means. For example, useful labels include ³²P, ³⁵S, fluorescent dyes, electron- dense reagents, enzymes (e.g., as commonly used in an ELISA), biotin- strep tavadin, dioxigenin, or nucleic acid molecules with a sequence complementary to a target. The detectable moiety often generates a measurable signal, such as a radioactive, chromogenic, or fluorescent signal, that can be used to quantify the amount of bound detectable moiety in a sample. The detectable moiety can be incorporated in or attached to a primer or probe either covalently, or through ionic, van der Waals or hydrogen bonds, e.g., incorporation of radioactive nucleotides, or biotinylated nucleotides that are recognized by streptavadin. The detectable moiety may be directly or indirectly detectable. Indirect detection can involve the binding of a second directly or indirectly detectable moiety to the detectable moiety. For example, the detectable moiety can be a nucleotide sequence, which is the binding partner for a complementary sequence, to which it can specifically hybridize. The binding partner may itself be directly detectable, for example, the partner may be itself labeled with a fluorescent molecule. The binding partner also may be indirectly detectable, for example, a nucleic acid having a complementary nucleotide sequence can be a part of a branched DNA molecule that is in turn detectable through hybridization with other labeled nucleic acid molecules (see, e.g., P. D. Fahrlander and A. Klausner, Bio/Technology 6:1 165 (1988)). Quantitation of the signal is achieved by, e.g., scintillation counting, densitometry, or flow cytometry.

Nucleic acids

A "nucleic acid fragment" or an "oligonucleotide" or a "polynucleotide" are used herein interchangeably to refer to a polymer of nucleic acids. A polynucleotide sequence of the present invention refers to a single or double stranded nucleic acid sequences which is isolated and provided in the form of an RNA sequence, a complementary polynucleotide sequence (cDNA), a genomic polynucleotide sequence and/or a composite polynucleotide sequences (e.g., a combination of the above).

As used herein the phrase "complementary polynucleotide sequence" refers to a sequence, which results from reverse transcription of messenger RNA using a reverse transcriptase or any other RNA dependent DNA polymerase. Such a sequence can be subsequently amplified in vivo or in vitro using a DNA dependent DNA polymerase.

As used herein the phrase "genomic polynucleotide sequence" refers to a sequence derived (isolated) from a chromosome and thus it represents a contiguous portion of a chromosome. As used herein the phrase "composite polynucleotide sequence" refers to a sequence, which is composed of genomic and cDNA sequences. A composite sequence can include some exonal sequences required to encode the polypeptide of the present invention, as well as some intronic sequences interposing therebetween. The intronic sequences can be of any source, including of other genes, and typically will include conserved splicing signal sequences. Such intronic sequences may further include cis acting expression regulatory elements.

Thus, the present invention encompasses nucleic acid sequences described hereinabove; fragments thereof, sequences hybridizable therewith, sequences homologous thereto [e.g., at least 50 %, at least 55 %, at least 60%, at least 65 %, at least 70 %, at least 75 %, at least 80 %, at least 85 %, at least 95 % or more say 100 % identical to the nucleic acid sequences set forth below], sequences encoding similar polypeptides with different codon usage, altered sequences characterized by mutations, such as deletion, insertion or substitution of one or more nucleotides, either naturally occurring or artificially induced, either randomly or in a targeted fashion. The present invention also encompasses homologous nucleic acid sequences (i.e., which form a part of a polynucleotide sequence of the present invention) which include sequence regions unique to the polynucleotides of the present invention. In cases where the polynucleotide sequences of the present invention encode previously unidentified polypeptides, the present invention also encompasses novel polypeptides or portions thereof, which are encoded by the isolated polynucleotide and respective nucleic acid fragments thereof described hereinabove.

Thus, the present invention also encompasses polypeptides encoded by the polynucleotide sequences of the present invention. The present invention also encompasses homologues of these polypeptides, such homologues can be at least 50 %, at least 55 %, at least 60%, at least 65 %, at least 70 %, at least 75 %, at least 80 %, at least 85 %, at least 95 % or more say 100 % homologous to the amino acid sequences set forth below, as can be determined using BlastP software of the National Center of Biotechnology Information (NCBI) using default parameters, optionally and preferably including the following: filtering on (this option filters repetitive or low- complexity sequences from the query using the SEG (protein) program), scoring matrix is BLOSUM62 for proteins, word size is 3, E value is 10, gap costs are 11, 1 (initialization and extension), and number of alignments shown is 50. Finally, the present invention also encompasses fragments of the above described polypeptides and polypeptides having mutations, such as deletions, insertions or substitutions of one or more amino acids, either naturally occurring or artificially induced, either randomly or in a targeted fashion.

As mentioned hereinabove, biomolecular sequences uncovered using the methodology of the present invention can be efficiently utilized as tissue or pathological markers and as putative drugs or drug targets for treating or preventing a disease. Oligonucleotides designed for carrying out the methods of the present invention for any of the sequences provided herein (designed as described above) can be generated according to any oligonucleotide synthesis method known in the art such as enzymatic synthesis or solid phase synthesis. Equipment and reagents for executing solid-phase synthesis are commercially available from, for example, Applied Biosystems. Any other means for such synthesis may also be employed; the actual synthesis of the oligonucleotides is well within the capabilities of one skilled in the art.

Oligonucleotides used according to this aspect of the present invention are those having a length selected from a range of about 10 to about 200 bases preferably about 15 to about 150 bases, more preferably about 20 to about 100 bases, most preferably about 20 to about 50 bases.

The oligonucleotides of the present invention may comprise heterocylic nucleosides consisting of purine and pyrimidine bases, bonded in a 3¹ to 5' phosphodiester linkage.

Preferably used oligonucleotides are those modified at one or more of backbone, internucleoside linkages or bases, as is broadly described hereinunder. Such modifications can oftentimes facilitate oligonucleotide uptake and resistivity to intracellular conditions.

Specific non- limiting examples of preferred oligonucleotides useful according to this aspect of the present invention include oligonucleotides containing modified backbones or non- natural internucleoside linkages. Oligonucleotides having modified backbones include those that retain a phosphorus atom in the backbone, as disclosed in U.S. Pat. NOs: ,687,808; 4,469,863; 4,476,301; 5,023,243; 5,177,196; 5,188,897; 5,264,423; 5,276,019; 5,278,302; 5,286,717; 5,321,131; 5,399,676; 5,405,939; 5,453,496; 5,455,233; 5,466, 677; 5,476,925; 5,519,126; 5,536,821; 5,541,306; 5,550,111; 5,563,253; 5,571,799; 5,587,361; and 5,625,050.

Preferred modified oligonucleotide backbones include, for example, phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkyl phosphotriesters, methyl and other alkyl phosphonates including 3'-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3'-amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkylphosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3'-5' linkages, 2'-5' linked analogs of these, and those having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3'-5' to 5'-3' or 2'-5' to 5'-2'. Various salts, mixed salts and free acid forms can also be used.

Alternatively, modified oligonucleotide backbones that do not include a phosphorus atom therein have backbones that are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. These include those having morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulfone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulfamate backbones; methyleneimino and methylenehydrazino backbones; sulfonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH₂ component parts, as disclosed in U.S. Pat. Nos. 5,034,506; 5,166,315; 5,185,444; 5,214,134; 5,216,141; 5,235,033; 5,264,562; 5,264,564; 5,405,938; 5,434,257; 5,466,677; 5,470,967; 5,489,677; 5,541,307; 5,561,225; 5,596,086; 5,602,240; 5,610,289; 5,602,240; 5,608,046; 5,610,289; 5,618,704; 5,623, 070; 5,663,312; 5,633,360; 5,677,437; and 5,677,439.

Other oligonucleotides which can be used according to the present invention, for example, are those modified in both sugar and the internucleoside linkage, i.e., the backbone, of the nucleotide units are replaced with novel groups. The base units are maintained for complementation with the appropriate polynucleotide target. An example for such an oligonucleotide mimetic includes but is not limited to peptide nucleic acid (PNA). A PNA oligonucleotide refers to an oligonucleotide where the sugar-backbone is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The bases are retained and are bound directly or indirectly to aza nitrogen atoms of the amide portion of the backbone. United States patents that teach the preparation of PNA compounds include, but are not limited to, U.S. Pat. Nos. 5,539,082; 5,714,331; and 5,719,262, each of which is herein incorporated by reference. Other non-limiting backbone modifications, which can be used in the present invention are disclosed in U.S. Pat. No: 6,303,374.

Oligonucleotides of the present invention may also include base modifications or substitutions. As used herein, "unmodified" or "natural" bases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified bases include but are not limited to other synthetic and natural bases such as 5- methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl and other 8- substituted adenines and guanines, 5-halo particularly 5-bromo, 5-trifluoromethyl and other 5- substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8- azaadenine, 7-deazaguanine and 7-deazaadenine and 3-deazaguanine and 3-deazaadenine. Further bases include those disclosed in U.S. Pat. No: 3,687,808, those disclosed in The Concise Encyclopedia Of Polymer Science and Engineering, pages 858-859, Kroschwitz, J. L, ed. John Wiley & Sons, 1990, those disclosed by Englisch et al., Angewandte Chemie, International Edition, 1991, 30, 613, and those disclosed by Sanghvi, Y. S., Chapter 15, Antisense Research and Applications, pages 289-302, Crooke, S. T. and Lebleu, B. , ed., CRC Press, 1993. Such bases are particularly useful for increasing the binding affinity of the oligomeric compounds of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and O-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6- 1.2⁰C. [Sanghvi YS et al. (1993) Antisense Research and Applications, CRC Press, Boca Raton 276-278] and are optional but preferred base substitutions, even more particularly when combined with 2'-O-methoxyethyl sugar modifications.

Another modification of the oligonucleotides of the invention involves chemically linking to the oligonucleotide one or more moieties or conjugates, which enhance the activity, cellular distribution or cellular uptake of the oligonucleotide. Such moieties include but are not limited to lipid moieties such as a cholesterol moiety, cholic acid, a thioether, e.g., hexyl-S- tritylthiol, a thiocholesterol, an aliphatic chain, e.g., dodecandiol or undecyl residues, a phospholipid, e.g., di-hexadecyl-rac- glycerol or triethylammonium 1,2-di-O-hexadecyl-rac- glycero-3-H-phosphonate, a polyamine or a polyethylene glycol chain, or adamantane acetic acid, a palmityl moiety, or an octadecylamine or hexylamino-carbonyl-oxycholesterol moiety, as disclosed in U.S. Pat. No: 6,303,374.

It is not necessary for all positions in a given oligonucleotide molecule to be uniformly modified, and in fact more than one of the aforementioned modifications may be incorporated in a single compound or even at a single nucleoside within an oligonucleotide.

DESCRIPTION OF PREFERRED EMBODIMENTS

The present invention provides novel variants, which may optionally be used as diagnostic markers.

Preferably these variants are useful as diagnostic markers for variant- detectable diseases. Differential variant markers are collectively described as "variant disease markers". Hybridization assays

Detection of a nucleic acid of interest in a biological sample may optionally be effected by hybridization-based assays using an oligonucleotide probe (non- limiting examples of probes according to the present invention are described in greater detail below).

Hybridization based assays which allow the detection of a variant of interest (i.e., DNA or RNA) in a biological sample rely on the use of oligonucleotide which can be 10, 15, 20, or 30 to 100 nucleotides long preferably from 10 to 50, more preferably from 40 to 50 nucleotides long. Hybridization of short nucleic acids (below 200 bp in length, e.g. 17-40 bp in length) can be effected using the following exemplary hybridization protocols which can be modified according to the desired stringency; (i) hybridization solution of 6 x SSC and 1 % SDS or 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS, 100 μg/ml denatured salmon sperm DNA and 0.1 % nonfat dried milk, hybridization temperature of 1 - 1.5 ⁰C below the T_1n, final wash solution of 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS at 1 - 1.5 ⁰C below the T_m; (H) hybridization solution of 6 x SSC and 0.1 % SDS or 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS, 100 μg/ml denatured salmon sperm DNA and 0.1 % nonfat dried milk, hybridization temperature of 2 - 2.5 ⁰C below the T_1n, final wash solution of 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS at 1 - 1.5 ⁰C below the T_1n, final wash solution of 6 x SSC, and final wash at 22 ⁰C; (Hi) hybridization solution of 6 x SSC and 1 % SDS or 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS, 100 μg/ml denatured salmon sperm DNA and 0.1 % nonfat dried milk, hybridization temperature. The detection of hybrid duplexes can be carried out by a number of methods. Typically, hybridization duplexes are separated from unhybridized nucleic acids and the labels bound to the duplexes are then detected. Such labels refer to radioactive, fluorescent, biological or enzymatic tags or labels of standard use in the art. A label can be conjugated to either the oligonucleotide probes or the nucleic acids derived from the biological sample. For example, oligonucleotides of the present invention can be labeled subsequent to synthesis, by incorporating biotinylated dNTPs or rNTP, or some similar means (e.g., photo- cross- linking a psoralen derivative of biotin to RNAs), followed by addition of labeled streptavidin (e.g., phycoerythrin-conjugated streptavidin) or the equivalent. Alternatively, when fluorescently- labeled oligonucleotide probes are used, fluorescein, lissamine, phycoerythrin, rhodamine (Perkin Elmer Cetus), Cy2, Cy3, Cy3.5, Cy5, Cy5.5, Cy7, FluorX (Amersham) and others [e.g., Kricka et al. (1992), Academic Press San Diego, Calif] can be attached to the oligonucleotides .

Traditional hybridization assays include PCR, RT-PCR, Real-time PCR, RNase protection, in-situ hybridization, primer extension, Southern blots (DNA detection), dot or slot blots (DNA, RNA), and Northern blots (RNA detection) (NAT type assays are described in greater detail below). More recently, PNAs have been described (Nielsen et al. 1999, Current Opin. Biotechnol. 10:71-75). Other detection methods include kits containing probes on a dipstick setup and the like. Although the present invention is not specifically dependent on the use of a label for the detection of a particular nucleic acid sequence, such a label might be beneficial, by increasing the sensitivity of the detection.

Furthermore, it enables automation. Probes can be labeled according to numerous well known methods (Sambrook et al., 1989, supra). Non- limiting examples of radioactive labels include ³H, ¹⁴C, ³²P, and ³⁵S. Non- limiting examples of detectable markers include ligands, fluorophores, chemiluminescent agents, enzymes, and antibodies. Other detectable markers for use with probes, which can enable an increase in sensitivity of the method of the invention, include biotin and radio-nucleotides. It will become evident to the person of ordinary skill that the choice of a particular label dictates the manner in which it is bound to the probe. As commonly known, radioactive nucleotides can be incorporated into probes of the invention by several methods. Non- limiting examples thereof include kinasing the 5' ends of the probes using gamma ATP and polynucleotide kinase, using the Klenow fragment of Pol I of E coli in the presence of radioactive dNTP (i.e. uniformly labeled DNA probe using random oligonucleotide primers in low- melt gels), using the SP6/T7 system to transcribe a DNA segment in the presence of one or more radioactive NTP, and the like. Those skilled in the art will appreciate that wash steps may be employed to wash away excess target DNA or probe as well as unbound conjugate. Further, standard heterogeneous assay formats are suitable for detecting the hybrids using the labels present on the oligonucleotide primers and probes. It will be appreciated that a variety of controls may be usefully employed to improve accuracy of hybridization assays. For instance, samples may be hybridized to an irrelevant probe and treated with RNAse A prior to hybridization, to assess false hybridization.

Probes of the invention can be utilized with naturally occurring sugar-phosphate backbones as well as modified backbones including phosphorothioates, dithionates, alkyl phosphonates and a- nucleotides and the like. Modified sugar-phosphate backbones are generally taught by Miller, 1988, Ann. Reports Med. Chem. 23:295 and Moran et al, 1987, Nucleic acid molecule. Acids Res., 14:5019. Probes of the invention can be constructed of either ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), and preferably of DNA.

NAT Assays

Detection of a nucleic acid of interest in a biological sample may also optionally be effected byNAT-based assays, which involve nucleic acid amplification technology, such as PCR for example (or variations thereof such as realtime PCR for example).

Amplification of a selected, or target, nucleic acid sequence may be carried out by a number of suitable methods. See generally Kwoh et al., 1990, Am. Biotechnol. Lab. 8:14 Numerous amplification techniques have been described and can be readily adapted to suit particular needs of a person of ordinary skill. Non- limiting examples of amplification techniques include polymerase chain reaction (PCR), ligase chain reaction (LCR), strand displacement amplification (SDA), transcription-based amplification, the q3 replicase system and NASBA (Kwoh et al., 1989, Proc. Natl. Acad. Sci. USA 86, 1173-1177; Lizardi et al., 1988,

BioTechnology 6:1197-1202; Malek et al., 1994, Methods MoI. Biol., 28:253-260; and Sambrook et al., 1989, supra).

Polymerase chain reaction (PCR) is carried out in accordance with known techniques, as described for example, in U.S. Pat. Nos. 4,683,195; 47683,202; 4.800,159; and 4,965,188 (the disclosures of all three U.S. patents are incorporated herein by reference). In general, PCR involves a treatment of a nucleic acid sample (e.g., in the presence of a heat stable DNA polymerase) under hybridizing conditions, with one oligonucleotide primer for each strand of the specific sequence to be detected. An extension product of each primer which is synthesized is complementary to each of the two nucleic acid strands, with the primers sufficiently complementary to each strand of the specific sequence to hybridize therewith. The extension product synthesized from each primer can also serve as a template for further synthesis of extension products using the same primers. Following a sufficient number of rounds of synthesis of extension products, the sample is analyzed to assess whether the sequence or sequences to be detected are present. Detection of the amplified sequence may be carried out by visualization following EtBr staining of the DNA following gel electrophores, or using a detectable label in accordance with known techniques, and the like. For a review of PCR techniques, see PCR Protocols, A Guide to Methods and Amplifications, Michael et al. Eds, Acad. Press, 1990.

As used herein, a "primer" defines an oligonucleotide which is capable of annealing to a target sequence, thereby creating a double stranded region which can serve as an initiation point for DNA synthesis under suitable conditions. Ligase chain reaction (LCR) is carried out in accordance with known techniques (Weiss,

1991, Science 254:1292). Adaptation of the protocol to meet the desired needs can be carried out by a person of ordinary skill. Strand displacement amplification (SDA) is also carried out in accordance with known techniques or adaptations thereof to meet the 1 5 particular needs (Walker et al., 1992, Proc. Natl. Acad. Sd. USA 89:392-396; and ibid., 1992, Nucleic Acids Res. 20:1691-1696).

The terminology "amplification pair" (or "primer pair") refers herein to a pair of oligonucleotides (oligos) of the present invention, which are selected to be used together in amplifying a selected nucleic acid sequence by one of a number of types of amplification processes, preferably a polymerase chain reaction. Other types of amplification processes include ligase chain reaction, strand displacement amplification, or nucleic acid sequence-based amplification, as explained in greater detail below. As commonly known in the art, the oligos are designed to bind to a complementary sequence under selected conditions.

In one particular embodiment, amplification of a nucleic acid sample from a patient is amplified under conditions which favor the amplification of the most abundant differentially expressed nucleic acid. In one preferred embodiment, RT-PCR is carried out on an mRNA sample from a patient under conditions which favor the amplification of the most abundant mRNA. In another preferred embodiment, the amplification of the differentially expressed nucleic acids is carried out simultaneously.

The nucleic acid (i.e. DNA or RNA) for practicing the present invention may be obtained according to well known methods. Oligonucleotide primers of the present invention may be of any suitable length, depending on the particular assay format and the particular needs and targeted genomes employed. In general, the oligonucleotide primers are at least 12 nucleotides in length, preferably between 15 and 24 molecules, and they may be adapted to be especially suited to a chosen nucleic acid amplification system. As commonly known in the art, the oligonucleotide primers can be designed by taking into consideration the melting point of hybridization thereof with its targeted sequence (see below and in Sambrook et al., 1989, Molecular Cloning -A Laboratory Manual, 2nd Edition, CSH Laboratories; Ausubel et al., 1989, in Current Protocols in Molecular Biology, John Wiley & Sons Inc., N.Y.).

Oligonucleotide Probes

Oligonucleotides according to the present invention may optionally be used as molecular probes as described herein. Such probes are use&l for hybridization assays, and also for NAT assays (as primers, for example).

Thus, the present invention encompasses nucleic acid sequences described hereinabove; fragments thereof, sequences hybridizable therewith, sequences homologous thereto, sequences encoding similar polypeptides with different codon usage, altered sequences characterized by mutations, such as deletion, insertion or substitution of one or more nucleotides, either naturally occurring or artificially induced, either randomly or in a targeted fashion.

Typically, detection of a nucleic acid of interest in a biological sample is effected by hybridization-based assays using an oligonucleotide probe.

The term "oligonucleotide" refers to a single stranded or double stranded oligomer or polymer of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) or mimetics thereof. This term includes oligonucleotides composed of naturally-occurring bases, sugars and covalent internucleoside linkages (e.g., backbone) as well as oligonucleotides having non-naturally- occurring portions which function similarly to respective naturally-occurring portions. An example of an oligonucleotide probe which can be utilized by the present invention is a single stranded polynucleotide which includes a sequence complementary to the unique sequence region of any variant according to the present invention, including but not limited to a nucleotide sequence coding for an amino sequence of a bridge, tail, head and/or insertion according to the present invention, and/or the equivalent portions of any nucleotide sequence given herein (including but not limited to a nucleotide sequence of a node, segment or amplicon described herein).

Alternatively, an oligonucleotide probe of the present invention can be designed to hybridize with a nucleic acid sequence encompassed by any of the above nucleic acid sequences, particularly the portions specified above, including but not limited to a nucleotide sequence coding for an amino sequence of a bridge, tail, head and/or insertion according to the present invention, and/or the equivalent portions of any nucleotide sequence given herein (including but not limited to a nucleotide sequence of a node, segment or amplicon described herein).

Oligonucleotides designed according to the teachings of the present invention can be generated according to any oligonucleotide synthesis method known in the art such as enzymatic synthesis or solid phase synthesis. Equipment and reagents for executing solid-phase synthesis are commercially available from, for example, Applied Biosystems. Any other means for such synthesis may also be employed; the actual synthesis of the oligonucleotides is well within the capabilities of one skilled in the art and can be accomplished via established methodologies as detailed in, for example, "Molecular Cloning: A laboratory Manual" Sambrook et al., (1989); "Current Protocols in Molecular Biology" Volumes I-III Ausubel, R. M., ed. (1994); Ausubel et al., "Current Protocols in Molecular Biology", John Wiley and Sons, Baltimore, Maryland (1989); Perbal, "A Practical Guide to Molecular Cloning", John Wiley & Sons, New York (1988) and "Oligonucleotide Synthesis" Gait, M. J., ed. (1984) utilizing solid phase chemistry, e.g. cyanoethyl phosphoramidite followed by deprotection, desalting and purification by for example, an automated trityl-on method or HPLC.

The oligonucleotide of the present invention is of at least 17, at least 18, at least 19, at least 20, at least 22, at least 25, at least 30 or at least 40, bases specifically hybridizable with the biomarkers of the present invention. The oligonucleotides of the present invention may comprise heterocylic nucleosides consisting of purines and the pyrimidines bases, bonded in a 3' to 5' phosphodiester linkage. Preferably used oligonucleotides are those modified at one or more of the backbone, interaucleoside linkages or bases, as is broadly described hereinunder.

Specific examples of preferred oligonucleotides useful according to this aspect of the present invention include oligonucleotides containing modified backbones or non- natural internucleoside linkages. Oligonucleotides having modified backbones include those that retain a phosphorus atom in the backbone, as disclosed in U.S. Pat. NOs: 4,469,863; 4,476,301; 5,023,243; 5,177,196; 5,188,897; 5,264,423; 5,276,019; 5,278,302; 5,286,717; 5,321,131; 5,399,676; 5,405,939; 5,453,496; 5,455,233; 5,466, 677; 5,476,925; 5,519,126; 5,536,821; 5,541,306; 5,550,111; 5,563,253; 5,571,799; 5,587,361; and 5,625,050. Preferred modified oligonucleotide backbones include, for example, phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkyl phosphotriesters, methyl and other alkyl phosphonates including 3'-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3'-amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkylphosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3'-5' linkages, 2'-5' linked analogs of these, and those having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3'-5' to 5'-3' or 2'-5' to 5'-2'. Various salts, mixed salts and free acid forms can also be used.

Alternatively, modified oligonucleotide backbones that do not include a phosphorus atom therein have backbones that are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. These include those having morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulfone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulfamate backbones; methyleneimino and methylenehydrazino backbones; sulfonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH₂ component parts, as disclosed h U.S. Pat. Nos. 5,034,506; 5,166,315; 5,185,444; 5,214,134; 5,216,141; 5,235,033; 5,264,562; 5,264,564; 5,405,938; 5,434,257; 5,466,677; 5,470,967; 5,489,677; 5,541,307; 5,561,225; 5,596,086; 5,602,240; 5,610,289; 5,602,240; 5,608,046; 5,610,289; 5,618,704; 5,623, 070; 5,663,312; 5,633,360; 5,677,437; and 5,677,439. Other oligonucleotides which can be used according to the present invention, are those modified in both sugar and the internucleoside linkage, i.e., the backbone, of the nucleotide units are replaced with novel groups. The base units are maintained for complementation with the appropriate polynucleotide target. An example for such an oligonucleotide mimetic, includes peptide nucleic acid (PNA). A PNA oligonucleotide refers to an oligonucleotide where the sugar-backbone is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The bases are retained and are bound directly or indirectly to aza nitrogen atoms of the amide portion of the backbone. United States patents that teach the preparation of PNA compounds include, but are not limited to, U.S. Pat. Nos. 5,539,082; 5,714,331; and 5,719,262, each of which is herein incorporated by reference. Other backbone modifications, which can be used in the present invention are disclosed in U.S. Pat. No: 6,303,374.

Oligonucleotides of the present invention may also include base modifications or substitutions. As used herein, "unmodified" or "natural" bases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified bases include but are not limited to other synthetic and natural bases such as 5- methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6- methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5 -uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl and other 8- substituted adenines and guanines, 5-halo particularly 5-bromo, 5-trifluoromethyl and other 5- substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8- azaadenine, 7-deazaguanine and 7-deazaadenine and 3-deazaguanine and 3-deazaadenine. Further bases include those disclosed in U.S. Pat. No: 3,687,808, those disclosed in The Concise Encyclopedia Of Polymer Science And Engineering, pages 858-859, Kroschwitz, J. L, ed. John Wiley & Sons, 1990, those disclosed by Englisch et al., Angewandte Chemie, International Edition, 1991, 30, 613, and those disclosed by Sanghvi, Y. S., Chapter 15, Antisense Research and Applications, pages 289-302, Crooke, S. T. and Lebleu, B. , ed., CRC Press, 1993. Such bases are particularly useful for increasing the binding affinity of the oligomeric compounds of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and O-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6- 1.2 ⁰C. [Sanghvi YS et al. (1993) Antisense Research and Applications, CRC Press, Boca Raton 276-278] and are presently preferred base substitutions, even more particularly when combined with 2'-O-methoxyethyl sugar modifications.

It will be appreciated that oligonucleotides of the present invention may include further modifications which increase bioavailability, therapeutic efficacy and reduce cytotoxicity. Such modifications are described in Younes (2002) Current Pharmaceutical Design 8:1451-1466.

The isolated polynucleotides of the present invention can optionally be detected (and optionally quantified) by using hybridization assays. Thus, the isolated polynucleotides of the present invention are preferably hybridizable with any of the above described nucleic acid sequences under moderate to stringent hybridization conditions.

Moderate to stringent hybridization conditions are characterized by a hybridization solution such as containing 10 % dextrane sulfate, 1 M NaCl, 1 % SDS and 5 x 10^ cpm ³²P labeled probe, at 65 ⁰C, with a final wash solution of 0.2 x SSC and 0.1 % SDS and final wash at 65⁰C and whereas moderate hybridization is effected using a hybridization solution containing 10 % dextrane sulfate, 1 M NaCl, 1 % SDS and 5 x 10⁶ cpm ³²P labeled probe, at 65 ⁰C, with a final wash solution of 1 x SSC and 0.1 % SDS and final wash at 50 ⁰C.

Hybridization based assays which allow the detection of the biomarkers of the present invention (i.e., DNA or RNA) in a biological sample rely on the use of oligonucleotides which can be 10, 15, 20, or 30 to 100 nucleotides long, preferably from 10 to 50, and more preferably from 40 to 50 nucleotides.

Hybridization of short nucleic acids (below 200 bp in length, e.g. 17-40 bp in length) can be effected using the following exemplary hybridization protocols which can be modified according to the desired stringency; (i) hybridization solution of 6 x SSC and 1 % SDS or 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS, 100 μg/ml denatured salmon sperm DNA and 0.1 % nonfat dried milk, hybridization temperature of 1 - 1.5 ⁰C below the T_1n, final wash solution of 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS at 1 - 1.5 ⁰C below the T_m; (H) hybridization solution of 6 x SSC and 0.1 % SDS or 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS, 100 μg/ml denatured salmon sperm DNA and 0.1 % nonfat dried milk, hybridization temperature of 2 - 2.5 ⁰C below the T_1n, final wash solution of 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS at 1 - 1.5 ⁰C below the T_m final wash solution of 6 x SSC, and final wash at 22 ⁰C; (Hi) hybridization solution of 6 x SSC and 1 % SDS or 3 M TMACI, 0.01 M sodium phosphate (pH 6.8), 1 mM EDTA (pH 7.6), 0.5 % SDS, 100 μg/ml denatured salmon sperm DNA and 0.1 % nonfat dried milk, hybridization temperature.

The detection of hybrid duplexes can be carried out by a number of methods. Typically, hybridization duplexes are separated from unhybridized nucleic acids and the labels bound to the duplexes are then detected. Such labels refer to radioactive, fluorescent, biological or enzymatic tags or labels of standard use in the art. A label can be conjugated to either the oligonucleotide probes or the nucleic acids derived from the biological sample (target).

For example, oligonucleotides of the present invention can be labeled subsequent to synthesis, by incorporating biotinylated dNTPs or rNTP, or some similar means (e.g., photo- cross- linking a psoralen derivative of biotin to RNAs), followed by addition of labeled streptavidin (e.g., phycoerythrin- conjugated streptavidin) or the equivalent. Alternatively, when fluorescently- labeled oligonucleotide probes are used, fluorescein, lissamine, phycoerythrin, rhodamine (Perkin Elmer Cetus), Cy2, Cy3, Cy3.5, Cy5, Cy5.5, Cy7, FluorX (Amersham) and others [e.g., Kricka et al. (1992), Academic Press San Diego, Calif] can be attached to the oligonucleotides.

Traditional hybridization assays include PCR, RT-PCR, Real-time PCR, RNase protection, in-situ hybridization, primer extension, Southern blots (DNA detection), dot or slot blots (DNA, RNA), and Northern blots (RNA detection) (NAT type assays are described in greater detail below). More recently, PNAs have been described (Nielsen et al. 1999, Current Opin. Biotechnol. 10:71-75). Other detection methods include kits containing probes on a dipstick setup and the like.

Although the present invention is not specifically dependent on the use of a label for the detection of a particular nucleic acid sequence, such a label might be beneficial, by increasing the sensitivity of the detection. Furthermore, it enables automation. Probes can be labeled according to numerous well known methods (Sambrook et al., 1989, supra). Non- limiting examples of radioactive labels include 3H, 14C, 32P, and 35S. Non- limiting examples of detectable markers include ligands, fluorophores, chemiluminescent agents, enzymes, and antibodies. Other detectable markers for use with probes, which can enable an increase in sensitivity of the method of the invention, include biotin and radio-nucleotides. It will become evident to the person of ordinary skill that the choice of a particular label dictates the manner in which it is bound to the probe.

As commonly known, radioactive nucleotides can be incorporated into probes of the invention by several methods. Non- limiting examples thereof include kinasing the 5' ends of the probes using gamma ATP and polynucleotide kinase, using the Klenow fragment of Pol I of E coli in the presence of radioactive dNTP (i.e. uniformly labeled DNA probe using random oligonucleotide primers in low- melt gels), using the SP6/T7 system to transcribe a DNA segment in the presence of one or more radioactive NTP, and the like.

Those skilled in the art will appreciate that wash steps may be employed to wash away excess target DNA or probe as well as unbound conjugate. Further, standard heterogeneous assay formats are suitable for detecting the hybrids using the labels present on the oligonucleotide primers and probes.

It will be appreciated that a variety of controls may be usefully employed to improve accuracy of hybridization assays. For instance, samples may be hybridized to an irrelevant probe and treated with RNAse A prior to hybridization, to assess false hybridization.

Probes of the invention can be utilized with naturally occurring sugar-phosphate backbones as well as modified backbones including phosphorothioates, dithionates, alkyl phosphonates and a- nucleotides and the like. Modified sugar-phosphate backbones are generally taught by Miller, 1988, Ann. Reports Med. Chem. 23:295 and Moran et al., 1987, Nucleic acid molecule. Acids Res., 14:5019. Probes of the invention can be constructed of either ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), and preferably of DNA.

Detection (and optionally quantification) of a nucleic acid of interest in a biological sample may also optionally be effected by NAT-based assays, which involve nucleic acid amplification technology, such as PCR for example (or variations thereof such as real-time PCR for example). Amplification of a selected, or target, nucleic acid sequence may be carried out by a number of suitable methods. See generally Kwoh et al., 1990, Am. Biotechnol. Lab. 8: 14 Numerous amplification techniques have been described and can be readily adapted to suit particular needs of a person of ordinary skill. Non- limiting examples of amplification techniques include polymerase chain reaction (PCR), ligase chain reaction (LCR), strand displacement amplification (SDA), transcription-based amplification, the q3 replicase system and NASBA (Kwoh et al., 1989, Proc. Natl. Acad. Sci. USA 86, 1173-1177; Lizardi et al., 1988, BioTechnology 6:1197-1202; Malek et al., 1994, Methods MoI. Biol., 28:253-260; and Sambrook et al., 1989, supra). Polymerase chain reaction (PCR) is carried out in accordance with known techniques, as described for example, in U.S. Pat. Nos. 4,683,195; 47683,202; 4,800,159; and 4,965,188 (the disclosures of all three U.S. patents are incorporated herein by reference). In general, PCR involves a treatment of a nucleic acid sample (e.g., in the presence of a heat stable DNA polymerase) under hybridizing conditions, with one oligonucleotide primer for each strand of the specific sequence to be detected. An extension product of each primer which is synthesized is complementary to each of the two nucleic acid strands, with the primers sufficiently complementary to each strand of the specific sequence to hybridize therewith. The extension product synthesized from each primer can also serve as a template for further synthesis of extension products using the same primers. Following a sufficient number of rounds of synthesis of extension products, the sample is analyzed to assess whether the sequence or sequences to be detected are present. Detection of the amplified sequence may be carried out by visualization following EtBr staining of the DNA following gel electrophores, or using a detectable label in accordance with known techniques, and the like. For a review of PCR techniques, see PCR Protocols, A Guide to Methods and Amplifications, Michael et al. Eds, Acad. Press, 1990. As used herein, a "primer" defines an oligonucleotide which is capable of annealing to a target sequence, thereby creating a double stranded region which can serve as an initiation point for DNA synthesis under suitable conditions.

Ligase chain reaction (LCR) is carried out in accordance with known techniques (Weiss, 1991, Science 254:1292). Adaptation of the protocol to meet the desired needs can be carried out by a person of ordinary skill. Strand displacement amplification (SDA) is also carried out in accordance with known techniques or adaptations thereof to meet the 1 5 particular needs (Walker et al., 1992, Proc. Natl. Acad. Sci. USA 89:392-396; and ibid., 1992, Nucleic Acids Res. 20:1691-1696).

The terminology "amplification pair" (or "primer pair") refers herein to a pair of oligonucleotides (oligos) of the present invention, which are selected to be used together in amplifying a selected nucleic acid sequence by one of a number of types of amplification processes, preferably a polymerase chain reaction. Other types of amplification processes include ligase chain reaction, strand displacement amplification, or nucleic acid sequence-based amplification, as explained in greater detail below. As commonly known in the art, the oligos are designed to bind to a complementary sequence under selected conditions. In one particular embodiment, amplification of a nucleic acid sample from a patient is amplified under conditions which favor the amplification of the most abundant differentially expressed nucleic acid. In one preferred embodiment, RT-PCR is carried out on an mRNA sample from a patient under conditions which favor the amplification of the most abundant mRNA. In another preferred embodiment, the amplification of the differentially expressed nucleic acids is carried out simultaneously.

The nucleic acid (i.e. DNA or RNA) for practicing the present invention may be obtained according to well known methods.

Oligonucleotide primers of the present invention may be of any suitable length, depending on the particular assay format and the particular needs and targeted genomes employed. In general, the oligonucleotide primers are at least 12 nucleotides in length, preferably between 15 and 24 molecules, and they may be adapted to be especially suited to a chosen nucleic acid amplification system. As commonly known in the art, the oligonucleotide primers can be designed by taking into consideration the melting point of hybridization thereof with its targeted sequence (see below and in Sambrook et al., 1989, Molecular Cloning -A Laboratory Manual, 2nd Edition, CSH Laboratories; Ausubel et al., 1989, in Current Protocols in Molecular Biology, John Wiley & Sons Inc., N.Y.).

It will be appreciated that antisense oligonucleotides may be employed to quantify expression of a splice isoform of interest. Such detection is effected at the pre-mRNA level. Essentially the ability to quantitate transcription from a splice site of interest can be effected based on splice site accessibility. Oligonucleotides may compete with splicing factors for the splice site sequences. Thus, low activity of the antisense oligonucleotide is indicative of splicing activity [see Sazani and KoIe (2003), supra].

Polymerase chain reaction (PCR)-based methods may be used to identify the presence of mRNA of the markers of the present invention. For PCR-based methods a pair of oligonucleotides is used, which is specifically hybridizable with the polynucleotide sequences described hereinabove in an opposite orientation so as to direct exponential amplification of a portion thereof (including the hereinabove described sequence alteration) in a nucleic acid amplification reaction. For example, oligonucleotide pairs of primers specifically hybridizable with nucleic acid sequences according to the present invention are described in greater detail with regard to the Examples below.

The polymerase chain reaction and other nucleic acid amplification reactions are well known in the art (various non- limiting examples of these reactions are described in greater detail below). The pair of oligonucleotides according to this aspect of the present invention are preferably selected to have compatible melting temperatures (Tm), e.g., melting temperatures which differ by less than that 7 ⁰C, preferably less than 5 ⁰C, more preferably less than 4 ⁰C, most preferably less than 3 ⁰C, ideally between 3 ⁰C and 0 ⁰C.

Hybridization to oligonucleotide arrays may be also used to determine expression of the biomarkers of the present invention (hybridization itself is described above). Such screening has been undertaken in the BRCAl gene and in the protease gene of HIV-I virus [see Hacia et al., (1996) Nat Genet 1996;14(4):441-447; Shoemaker et al., (1996) Nat Genet 1996;14(4):450-456; Kozal et al., (1996) Nat Med 1996;2(7):753-759]. Optionally and preferably, such hybridization is combined with amplification as described herein.

The nucleic acid sample which includes the candidate region to be analyzed is preferably isolated, amplified and labeled with a reporter group. This reporter group can be a fluorescent group such as phycoerythrin. The labeled nucleic acid is then incubated with the probes immobilized on the chip using a fluidics station. For example, Manz et al. (1993) Adv in Chromatogr 1993; 33:1-66 describe the fabrication of fluidics devices and particularly microcapillary devices, in silicon and glass substrates.

Once the reaction is completed, the chip is inserted into a scanner and patterns of hybridization are detected. The hybridization data is collected, as a signal emitted from the reporter groups already incorporated into the nucleic acid, which is now bound to the probes attached to the chip. Since the sequence and position of each probe immobilized on the chip is known, the identity of the nucleic acid hybridized to a given probe can be determined.

It will be appreciated that when utilized along with automated equipment, the above described detection methods can be used to screen multiple samples for ferretin light chain variant detectable disease both rapidly and easily.

According to various preferred embodiments of the methods of the present invention, determining the presence and/or level of any specific nucleic or amino acid in a biological sample obtained from, for example, a patient is effected by any one of a variety of methods including, but not limited to, a signal amplification method, a direct detection method and detection of at least one sequence change.

The signal amplification methods according to various preferred embodiments of the present invention may amplify, for example, a DNA molecule or an RNA molecule. Signal amplification methods which might be used as part of the present invention include, but are not limited to PCR, LCR (LAR), Self-Sustained Synthetic Reaction (3SR/NASBA) or a Q-Beta (Q β) Replicase reaction.

Polymerase Chain Reaction (PCR): The polymerase chain reaction (PCR), as described in U.S. Pat. Nos. 4,683,195 and 4,683,202 to Mullis and Mullis et ah, is a method of increasing the concentration of a segment of target sequence in a mixture of genomic DNA without cloning or purification. This technology provides one approach to the problems of low target sequence concentration. PCR can be used to directly increase the concentration of the target to an easily detectable level. This process for amplifying the target sequence involves the introduction of a molar excess of two oligonucleotide primers which are complementary to their respective strands of the double -stranded target sequence to the DNA mixture containing the desired target sequence. The mixture is denatured and then allowed to hybridize. Following hybridization, the primers are extended with polymerase so as to form complementary strands, denaturation, hybridization (annealing), and polymerase extension (elongation) can be repeated as often as needed, in order to obtain relatively high concentrations of a segment of the desired target sequence. The length of the segment of the desired target sequence is determined by the relative positions of the primers with respect to each other, and, therefore, this length is a controllable parameter. Because the desired segments of the target sequence become the dominant sequences (in terms of concentration) in the mixture, they are said to be "PCR- amplified." Ligase Chain Reaction (LCR or LAR): The ligase chain reaction [LCR; sometimes referred to as "Ligase Amplification Reaction" (LAR)] described by Barany, Proc. Natl. Acad. Sci., 88:189 (1991); Barany, PCR Methods and Applic, 1:5 (1991); and Wu and Wallace, Genomics 4:560 (1989) has developed into a well- recognized alternative method of amplifying nucleic acids. In LCR, four oligonucleotides, two adjacent oligonucleotides which uniquely hybridize to one strand of target DNA, and a complementary set of adjacent oligonucleotides, which hybridize to the opposite strand are mixed and DNA ligase is added to the mixture. Provided that there is complete complementarity at the junction, ligase will covalently link each set of hybridized molecules. Importantly, in LCR, two probes are ligated together only when they base-pair with sequences in the target sample, without gaps or mismatches. Repeated cycles of denaturation, and ligation amplify a short segment of DNA. LCR has also been used in combination with PCR to achieve enhanced detection of single-base changes; see for example Segev, PCT Publication No. W09001069 Al (1990). However, because the four oligonucleotides used in this assay can pair to form two short ligatable fragments, there is the potential for the generation of target- independent background signal. The use of LCR for mutant screening is limited to the examination of specific nucleic acid positions.

Self-Sustained Synthetic Reaction (3SR/NASBA): The self- sustained sequence replication reaction (3SR) (Guatelli et ah, Proc. Natl. Acad. Sci., 87:1874-1878, 1990), with an erratum at Proc. Natl. Acad. Sci., 87:7797, 1990) is a transcription-based in vitro amplification system (Kwok et ah, Proc. Natl. Acad. Sci., 86:1173-1177, 1989) that can exponentially amplify RNA sequences at a uniform temperature. The amplified RNA can then be utilized for mutation detection (Fahy et al., PCR Meth. Appl., 1:25-33, 1991). In this method, an oligonucleotide primer is used to add a phage RNA polymerase promoter to the 5' end of the sequence of interest. In a cocktail of enzymes and substrates that includes a second primer, reverse transcriptase, RNase H, RNA polymerase and ribo-and deoxyribonucleoside triphosphates, the target sequence undergoes repeated rounds of transcription, cDNA synthesis and second-strand synthesis to amplify the area of interest. The use of 3SR to detect mutations is kinetically limited to screening small segments of DNA (e.g., 200-300 base pairs).

Q-B eta (Q β) Replicase: In this method, a probe which recognizes the sequence of interest is attached to the replicatable KNA template for Qβ replicase. A previously identified major problem with false positives resulting from the replication of unhybridized probes has been addressed through use of a sequence- specific ligation step. However, available thermostable DNA ligases are not effective on this RNA substrate, so the ligation must be performed by T4 DNA ligase at low temperatures (37 degrees C). This prevents the use of high temperature as a means of achieving specificity as in the LCR, the ligation event can be used to detect a mutation at the junction site, but not elsewhere.

A successful diagnostic method must be very specific. A straight-forward method of controlling the specificity of nucleic acid hybridization is by controlling the temperature of the reaction. While the 3SR/NASBA, and Qβ systems are all able to generate a large quantity of signal, one or more of the enzymes involved in each cannot be used at high temperature (i.e., > 55 degrees C). Therefore the reaction temperatures cannot be raised to prevent non-specific hybridization of the probes. If probes are shortened in order to make them melt more easily at low temperatures, the likelihood of having more than one perfect match in a complex genome increases. For these reasons, PCR and LCR currently dominate the research field in detection technologies. The basis of the amplification procedure in the PCR and LCR is the fact that the products of one cycle become usable templates in all subsequent cycles, consequently doubling the population with each cycle. The final yield of any such doubling system can be expressed as: (1+X)ⁿ=y, where "X" is the mean efficiency (percent copied in each cycle), "n" is the number of cycles, and "y" is the overall efficiency, or yield of the reaction (Mullis, PCR Methods Applic, 1:1, 1991). If every copy of a target DNA is utilized as a template in every cycle of a polymerase chain reaction, then the mean efficiency is 100 %. If 20 cycles of PCR are performed, then the yield will be 2^O_{5 or} 1,048,576 copies of the starting material. If the reaction conditions reduce the mean efficiency to 85 %, then the yield in those 20 cycles will be only

1.85-20, _or 220,513 copies of the starting material. In other words, a PCR running at 85 % efficiency will yield only 21 % as much final product, compared to a reaction running at 100 % efficiency. A reaction that is reduced to 50 % mean efficiency will yield less than 1 % of the possible product.

In practice, routine polymerase chain reactions rarely achieve the theoretical maximum yield, and PCRs are usually run for more than 20 cycles to compensate for the lower yield. At 50 % mean efficiency, it would take 34 cycles to achieve the million-fold amplification theoretically possible in 20, and at lower efficiencies, the number of cycles required becomes prohibitive. In addition, any background products that amplify with a better mean efficiency than the intended target will become the dominant products.

Also, many variables can influence the mean efficiency of PCR, including target DNA length and secondary structure, primer length and design, primer and dNTP concentrations, and buffer composition, to name but a few. Contamination of the reaction with exogenous DNA (e.g., DNA spilled onto lab surfaces) or cross-contamination is also a major consideration. Reaction conditions must be carefully optimized for each different primer pair and target sequence, and the process can take days, even for an experienced investigator. The laboriousness of this process, including numerous technical considerations and other factors, presents a significant drawback to using PCR in the clinical setting. Indeed, PCR has yet to penetrate the clinical market in a significant way. The same concerns arise with LCR, as LCR must also be optimized to use different oligonucleotide sequences for each target sequence. In addition, both methods require expensive equipment, capable of precise temperature cycling. Many applications of nucleic acid detection technologies, such as in studies of allelic variation, involve not only detection of a specific sequence in a complex background, but also the discrimination between sequences with few, or single, nucleotide differences. One method of the detection of allele -specific variants by PCR is based upon the fact that it is difficult for Taq polymerase to synthesize a DNA strand when there is a mismatch between the template strand and the 3' end of the primer. An allele -specific variant may be detected by the use of a primer that is perfectly matched with only one of the possible alleles; the mismatch to the other allele acts to prevent the extension of the primer, thereby preventing the amplification of that sequence. This method has a substantial limitation in that the base composition of the mismatch influences the ability to prevent extension across the mismatch, and certain mismatches do not prevent extension or have only a minimal effect (Kwok et al., Nucl. Acids Res., 18:999, 1990) A similar 3'- mismatch strategy is used with greater effect to prevent ligation in the LCR (Barany, PCR Meth. Applic, 1:5, 1991). Any mismatch effectively blocks the action of the thermostable ligase, but LCR still has the drawback of target- independent background ligation products initiating the amplification. Moreover, the combination of PCR with subsequent LCR to identify the nucleotides at individual positions is also a clearly cumbersome proposition for the clinical laboratory.

The direct detection method according to various preferred embodiments of the present invention may be, for example a cycling probe reaction (CPR) or a branched DNA analysis.

When a sufficient amount of a nucleic acid to be detected is available, there are advantages to detecting that sequence directly, instead of making more copies of that target, (e.g., as in PCR and LCR). Most notably, a method that does not amplify the signal exponentially is more amenable to quantitative analysis. Even if the signal is enhanced by attaching multiple dyes to a single oligonucleotide, the correlation between the final signal intensity and amount of target is direct. Such a system has an additional advantage that the products of the reaction will not themselves promote further reaction, so contamination of lab surfaces by the products is not as much of a concern. Traditional methods of direct detection including Northern and Southern band RNase protection assays usually require the use of radioactivity and are not amenable to automation. Recently devised techniques have sought to eliminate the use of radioactivity and/or improve the sensitivity in automatable formats. Two examples are the 'Cycling Probe Reaction" (CPR), and "Branched DNA" (bDNA).

Cycling probe reaction (CPR): The cycling probe reaction (CPR) (Duck et al., BioTech., 9:142, 1990), uses a long chimeric oligonucleotide in which a central portion is made of RNA while the two termini are made of DNA. Hybridization of the probe to a target DNA and exposure to a thermostable RNase H causes the RNA portion to be digested. This destabilizes the remaining DNA portions of the duplex, releasing the remainder of the probe from the target DNA and allowing another probe molecule to repeat the process. The signal, in the form of cleaved probe molecules, accumulates at a linear rate. While the repeating process increases the signal, the RNA portion of the oligonucleotide is vulnerable to RNases that may carried through sample preparation. Branched DNA: Branched DNA (bDNA), described by Urdea et al, Gene 61:253-264

(1987), involves oligonucleotides with branched structures that allow each individual oligonucleotide to carry 35 to 40 labels (e.g., alkaline phosphatase enzymes). While this enhances the signal from a hybridization event, signal from non-specific binding is similarly increased.

The detection of at least one sequence change according to various preferred embodiments of the present invention may be accomplished by, for example restriction fragment length polymorphism (RFLP analysis), allele specific oligonucleotide (ASO) analysis, Denaturing/Temperature Gradient Gel Electrophoresis (DGGE/TGGE), Single- Strand Conformation Po lymorphism (SSCP) analysis or Dideoxy fingerprinting (ddF).

The demand for tests which allow the detection of specific nucleic acid sequences and sequence changes is growing rapidly in clinical diagnostics. As nucleic acid sequence data for genes from humans and pathogenic organisms accumulates, the demand for fast, cost-effective, and easy-to-use tests for as yet mutations within specific sequences is rapidly increasing.

A handful of methods have been devised to scan nucleic acid segments for mutations. One option is to determine the entire gene sequence of each test sample (e.g., a bacterial isolate). For sequences under approximately 600 nucleotides, this may be accomplished using amplified material (e.g., PCR reaction products). This avoids the time and expense associated with cloning the segment of interest. However, specialized equipment and highly trained personnel are required, and the method is too labor- intense and expensive to be practical and effective in the clinical setting. In view of the difficulties associated with sequencing, a given segment of nucleic acid may be characterized on several other levels. At the lowest resolution, the size of the molecule can be determined by electrophoresis by comparison to a known standard run on the same gel. A more detailed picture of the molecule may be achieved by cleavage with combinations of restriction enzymes prior to electrophoresis, to allow construction of an ordered map. The presence of specific sequences within the fragment can be detected by hybridization of a labeled probe, or the precise nucleotide sequence can be determined by partial chemical degradation or by primer extension in the presence of chain- terminating nucleotide analogs.

Restriction fragment length polymorphism (RFLP): For detection of single-base differences between like sequences, the requirements of the analysis are often at the highest level of resolution. For cases in which the position of the nucleotide in question is known in advance, several methods have been developed for examining single base changes without direct sequencing. For example, if a mutation of interest happens to fall within a restriction recognition sequence, a change in the pattern of digestion can be used as a diagnostic tool (e.g., restriction fragment length polymorphism [RFLP] analysis).

Single point mutations have been also detected by the creation or destruction of RFLPs. Mutations are detected and localized by the presence and size of the RNA fragments generated by cleavage at the mismatches. Single nucleotide mismatches in DNA heteroduplexes are also recognized and cleaved by some chemicals, providing an alternative strategy to detect single base substitutions, generically named the "Mismatch Chemical Cleavage" (MCC) (Gogos et al., Nucl Acids Res., 18:6807-6817, 1990). However, this method requires the use of osmium tetroxide and piperidine, two highly noxious chemicals which are not suited for use in a clinical laboratory.

RFLP analysis suffers from low sensitivity and requires a large amount of sample. When RFLP analysis is used for the detection of point mutations, it is, by its nature, limited to the detection of only those single base changes which fall within a restriction sequence of a known restriction endonuclease. Moreover, the majority of the available enzymes have 4 to 6 base-pair recognition sequences, and cleave too frequently for many large-scale DNA manipulations (Eckstein and Lilley (eds.), Nucleic Acids and Molecular Biology, vol. 2, Springer- Verlag, Heidelberg, 1988). Thus, it is applicable only in a small fraction of cases, as most mutations do not fall within such sites. A handful of rare-cutting restriction enzymes with 8 base-pair specificities have been isolated and these are widely used in genetic mapping, but these enzymes are few in number, are limited to the recognition of G+C-rich sequences, and cleave at sites that tend to be highly clustered (Barlow and Lehrach, Trends Genet., 3:167, 1987). Recently, endonucleases encoded by group I introns have been discovered that might have greater than 12 base-pair specificity (Perlman and Butow, Science 246:1106, 1989), but again, these are few in number.

Allele specific oligonucleotide (ASO): If the change is not in a recognition sequence, then allele-specific oligonucleotides (ASOs), can be designed to hybridize in proximity to the mutated nucleotide, such that a primer extension or ligation event can bused as the indicator of a match or a mis-match. Hybridization with radioactively labeled allelic specific oligonucleotides (ASO) also has been applied to the detection of specific point mutations (Conner et ah, Proc. Natl. Acad. ScL, 80:278-282, 1983). The method is based on the differences in the melting temperature of short DNA fragments differing by a single nucleotide. Stringent hybridization and washing conditions can differentiate between mutant and wild-type alleles. The ASO approach applied to PCR products also has been extensively utilized by various researchers to detect and characterize point nutations in ras genes (Vogelstein et al, N. Eng. J. Med., 319:525-532, 1988; and Farr e? α/., Proc. Natl. Acad. ScL, 85:1629-1633, 1988), and gsp/gip oncogenes (Lyons et al, Science 249:655-659, 1990). Because of the presence of various nucleotide changes in multiple positions, the ASO method requires the use of many oligonucleotides to cover all possible oncogenic mutations.

With either of the techniques described above (i.e., PvFLP and ASO), the precise location of the suspected mutation must be known in advance of the test. That is to say, they are inapplicable when one needs to detect the presence of a mutation within a gene or sequence of interest.

Denaturing/Temperature Gradient Gel Electrophoresis (DGGE/TGGE): Two other methods rely on detecting changes in electrophoretic mobility in response to minor sequence changes. One of these methods, termed "Denaturing Gradient Gel Electrophoresis" (DGGE) is based on the observation that slightly different sequences will display different patterns of local melting when electrophoretically resolved on a gradient gel. In this manner, variants can be distinguished, as differences in melting properties of homoduplexes versus heteroduplexes differing in a single nucleotide can detect the presence of mutations in the target sequences because of the corresponding changes in their electrophoretic mobilities. The fragments to be analyzed, usually PCR products, are "clamped" at one end by a long stretch of GC base pairs (30-80) to allow complete denaturation of the sequence of interest without complete dissociation of the strands. The attachment of a GC "clamp" to the DNA fragments increases the fraction of mutations that can be recognized by DGGE (Abrams et al., Genomics 7:463-475, 1990). Attaching a GC clamp to one primer is critical to ensure that the amplified sequence has a low dissociation temperature (Sheffield et al, Proc. Natl. Acad. ScL, 86:232-236, 1989; and Lerman and Silverstein, Meth. Enzymol., 155:482-501, 1987). Modifications of the technique have been developed, using temperature gradients (Wartell et al, Nucl. Acids Res., 18:2699- 2701, 1990), and the method can be also applied to RNA:RNA duplexes (Smith et al, Genomics 3:217-223, 1988). Limitations on the utility of DGGE include the requirement that the denaturing conditions must be optimized for each type of DNA to be tested. Furthermore, the method requires specialized equipment to prepare the gels and maintain the needed high temperatures during electrophoresis. The expense associated with the synthesis of the clamping tail on one oligonucleotide for each sequence to be tested is also a major consideration. In addition, long running times are required for DGGE. The long running time of DGGE was shortened in a modification of DGGE called constant denaturant gel electrophoresis (CDGE) (Borrensen et al,

Proc. Natl. Acad. Sci. USA 88:8405, 1991). CDGE requires that gels be performed under different denaturant conditions in order to reach high efficiency for the detection of mutations. A technique analogous to DGGE, termed temperature gradient gel electrophoresis

(TGGE), uses a thermal gradient rather than a chemical denaturant gradient (Scholz, et al, Hum.

MoI. Genet. 2:2155, 1993). TGGE requires the use of specialized equipment which can generate a temperature gradient perpendicularly oriented relative to the electrical field. TGGE can detect mutations in relatively small fragments of DNA therefore scanning of large gene segments requires the use of multiple PCR products prior to running the gel.

Single-Strand Conformation Polymorphism (SSCP): Another common method, called "Single- Strand Conformation Polymorphism" (SSCP) was developed by Hayashi, Sekya and colleagues (reviewed by Hayashi, PCR Meth. Appl., 1:34-38, 1991) and is based on the observation that single strands of nucleic acid can take on characteristic conformations in non- denaturing conditions, and these confoπnations influence electrophoretic mobility. The complementary strands assume sufficiently different structures that one strand may be resolved from the other. Changes in sequences within the fragment will also change the conformation, consequently altering the mobility and allowing this to be used as an assay for sequence variations (Orita, et al, Genomics 5:874-879, 1989). The SSCP process involves denaturing a DNA segment (e.g., a PCR product) that is labeled on both strands, followed by slow electrophoretic separation on a non-denaturing polyacrylamide gel, so that intra- molecular interactions can form and not be disturbed during the run. This technique is extremely sensitive to variations in gel composition and temperature. A serious limitation of this method is the relative difficulty encountered in comparing data generated in different laboratories, under apparently similar conditions. Dideoxy fingerprinting (ddF): The dideoxy fingerprinting (ddF) is another technique developed to scan genes for the presence of mutations (Liu and Sominer, PCR Methods Appli., 4:97, 1994). The ddF technique combines components of Sanger dideoxy sequencing with SSCP. A dideoxy sequencing reaction is performed using one dideoxy terminator and then the reaction products are electrophoresed on nondenaturing polyacrylamide gels to detect alterations in mobility of the termination segments as in SSCP analysis. While ddF is an improvement over SSCP in terms of increased sensitivity, ddF requires the use of expensive dideoxynucleotides and this technique is still limited to the analysis of fragments of the size suitable for SSCP (i.e., fragments of 200-300 bases for optimal detection of mutations). In addition to the above limitations, all of these methods are limited as to the size of the nucleic acid fragment that can be analyzed. For the direct sequencing approach, sequences of greater than 600 base pairs require cloning, with the consequent delays and expense of either deletion sub-cloning or primer walking, in order to cover the entire fragment. SSCP and DGGE have even more severe size limitations. Because of reduced sensitivity to sequence changes, these methods are not considered suitable for larger fragments. Although SSCP is reportedly able to detect 90 % of single-base substitutions within a 200 base-pair fragment, the detection drops to less than 50 % for 400 base pair fragments. Similarly, the sensitivity of DGGE decreases as the length of the fragment reaches 500 base-pairs. The ddF technique, as a combination of direct sequencing and SSCP, is also limited by the relatively small size of the DNA that can be screened.

According to a presently preferred embodiment of the present invention the step of searching for the mutation or mutations in any of the genes listed above, such as, for example, the reduced folate carrier (RFC) gene, in tumor cells or in cells derived from a cancer patient is effected by a single strand conformational polymorphism (SSCP) technique, such as cDNA- SSCP or genomic DNA-SSCP. However, alternative methods can be employed, including, but not limited to, nucleic acid sequencing, polymerase chain reaction, ligase chain reaction, self- sustained synthetic reaction, Qβ-Replicase, cycling probe reaction, branched DNA, restriction fragment length polymorphism analysis, mismatch chemical cleavage, heteroduplex analysis, allele- specific oligonucleotides, denaturing gradient gel electrophoresis, constant denaturant gel electrophoresis, temperature gradient gel electrophoresis and dideoxy fingerprinting. The following sections relate to Candidate Marker Examples (first section).

CANDIDATE MARKER EXAMPLES SECTION

This Section relates to Examples of sequences according to the present invention, including illustrative methods of selection thereof.

A brief explanation is provided with regard to the method of selecting the candidates. However, it should noted that this explanation is provided for descriptive purposes only, and is not intended to be limiting in any way. The potential markers were identified by a computational process that was designed to find genes and/or their splice variants that are over- expressed in tumor tissues, by using databases of expressed sequences. Various parameters related to the information in the EST libraries, determined according to a manual classification process, were used to assist in locating genes and/or splice variants thereof that are over-expressed in cancerous tissues. The detailed description of the selection method is presented in Example 1 below. The cancer biomarkers selection engine and the following wet validation stages are schematically summarized in Figure 1.

EXAMPLE l Identification of differentially expressed gene products — A lgorithm

In order to distinguish between differentially expressed gene products and constitutively expressed genes (i.e., house keeping genes ) an algorithm based on an analysis of frequencies was configured. A specific algorithm for identification of transcripts over expressed in cancer is described hereinbelow. Dry analysis

Library annotation — EST libraries are manually classified according to:

• Tissue origin

• Biological source - Examples of frequently used biological sources for construction of EST libraries include cancer cell- lines; normal tissues; cancer tissues; fetal tissues; and others such as normal cell lines and pools of normal cell- lines, cancer cell- lines and combinations thereof. A specific description of abbreviations used below with regard to these tissues/cell lines etc is given above. • Protocol of library construction - various methods are known in the art for library construction including normalized library construction; non-normalized library construction; subtracted libraries; ORESTES and others. It will be appreciated that at times the protocol of library construction is not indicated.

The following rules are followed:

EST libraries originating from identical biological samples are considered as a single library.

EST libraries which include above-average levels of DNA contamination are eliminated.

Dry computation - development of engines which are capable of identifying genes and splice variants that are temporally and spacially expressed.

Clusters (genes) having at least five sequences including at least two sequences from the tissue of interest are analyzed.

EXAMPLE 2

Identification of genes over expressed in cancer. Two different scoring algorithms were developed. Libraries score -candidate sequences which are supported by a number of cancer libraries, are more likely to serve as specific and effective diagnostic markers.

The basic algorithm - for each cluster the number of cancer and normal libraries contributing sequences to the cluster was counted. Fisher exact test was used to check if cancer libraries are significantly over-represented in the cluster as compared to the total number of cancer and normal libraries.

Library counting: Small libraries (e.g., less than 1000 sequences) were excluded from consideration unless they participate in the cluster. For this reason, the total number of libraries is actually adjusted for each cluster.

Clones no. score — Generally, when the number of ESTs is much higher in the cancer libraries relative to the normal libraries it might indicate actual over- expression. The algorithm - Clone counting: For counting EST clones each library protocol class was given a weight based on our belief of how much the protocol reflects real expression levels:

(i) non-normalized : 1

(ii) normalized : 0.2 (iii) all other classes : 0.1

Clones number score - The total weighted number of EST clones from cancer libraries was compared to the EST clones from normal libraries. To avoid cases where one library contributes to the majority of the score, the contribution of the library that gives most clones for a given cluster was limited to 2 clones. The score was computed as

where: c — weighted number of "cancer" clones in the cluster.

C- weighted number of clones in all "cancer" libraries. n - weighted number of "normal" clones in the cluster.

Ν- weighted number of clones in all "normal" libraries.

Clones number score significance - Fisher exact test was used to check if EST clones from cancer libraries are significantly over-represented in the cluster as compared to the total number of EST clones from cancer and normal libraries.

Two search approaches were used to find either general cancer- specific candidates or tumor specific candidates.

• Libraries/sequences originating from tumor tissues are counted as well as libraries originating from cancer cell- lines ("normal" cell- lines were ignored).

• Only libraries/sequences originating from tumor tissues are counted EXAMPLE 3

Identification of tissue specific genes

For detection of tissue specific clusters, tissue libraries/sequences were compared to the total number of libraries/sequences in cluster. Similar statistical tools to those described in above were employed to identify tissue specific genes. Tissue abbreviations are the same as for cancerous tissues, but are indicated with the header "normal tissue".

The algorithm - for each tested tissue T and for each tested cluster the following were examined:

1. Each cluster includes at least 2 libraries from the tissue T. At least 3 clones (weighed - as described above) from tissue T in the cluster; and

2. Clones from the tissue T are at least 40 % from all the clones participating in the tested cluster

Fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant.

EXAMPLE 4

Identification of splice variants over expressed in cancer of clusters which are not over expressed in cancer

Cancer- specific splice variants containing a unique region were identified.

Identification of unique sequence regions in splice variants

A Region is defined as a group of adjacent exons that always appear or do not appear together in each splice variant.

A "segment" (sometimes referred also as "seg" or "node") is defined as the shortest contiguous transcribed region without known splicing inside.

Only reliable ESTs were considered for region and segment analysis. An EST was defined as unreliable if: (i) Unspliced; (ii) Not covered by RNA; (iii) Not covered by spliced ESTs; and (iv) Alignment to the genome ends in proximity of long poly-A stretch or starts in proximity of long poly- T stretch.

Only reliable regions were selected for firmer scoring. Unique sequence regions were considered reliable if: (i) Aligned to the genome; and

(ii) Regions supported by more than 2 ESTs.

The algorithm

Each unique sequence region divides the set of transcripts into 2 groups:

(i) Transcripts containing this region (group TA). (ii) Transcripts not containing this region (group TB).

The set of EST clones of every cluster is divided into 3 groups:

(i) Supporting (originating from) transcripts of group TA (Sl).

(ii) Supporting transcripts of group TB (S2).

(iii) Supporting transcripts from both groups (S3). Library and clones number scores described above were given to Sl group.

Fisher Exact Test P- values were used to check if:

Sl is significantly enriched by cancer EST clones compared to S2; and

Sl is significantly enriched by cancer EST clones compared to cluster background (S1+S2+S3). Identification of unique sequence regions and division of the group of transcripts accordingly is illustrated in Figure 2. Each of these unique sequence regions corresponds to a segment, also termed herein a "node".

Region 1: common to all transcripts, thus it is not considered; Region 2: specific to Transcript 1: T_l unique regions (2+6) against T_2+3 unique regions (3+4); Region 3: specific to Transcripts 2+3: T_2+3 unique regions (3+4) against Tl unique regions (2+6); Region 4: specific to Transcript 3: T_3 unique regions (4) against Tl+2 unique regions (2+5+6); Region 5: specific to Transcript 1+2: T_l+2 unique regions (2+5+6) against T3 unique regions (4); Region 6: specific to Transcript 1: same as region 2.

EXAMPLE 5 Identification of cancer specific splice variants of genes over expressed in cancer A search for EST supported (no mRNA) regions for genes of: (i) known cancer markers

(ii) Genes shown to be over- expressed in cancer in published micro-array experiments. Reliable EST supported-regions were defined as supported by minimum of one of the following:

(i) 3 spliced ESTs; or (ii) 2 spliced ESTs from 2 libraries; (iii) 10 unspliced ESTs from 2 libraries, or (iv) 3 libraries.

Actual Marker Examples

The following examples relate to specific actual marker examples. It should be noted that Figure and Table numbering is restarted within each example related to a particular Cluster, as indicated by the titles bebw. Before the cluster descriptions, there is provided a description of the categories into which each cluster falls with regard to diagnostic utility or utilities.

Heart

Z24779

C03950

C03218

AA436634

D62617

H79892

AL600896

AA722065

H88495_PEA_3

Z30117_PEA_l

Z18303_PEA_l

HSACMHCP_PEA_1

HUMANFB_PEA_1

ChipColon

HUMCAlXIA

Rl 0078

H41850

HSB6PR

R49883 Dl 1793

Z44716

HSCDC2

Z20721

HUMRAP IGAP

HUMCEA

R00317_PEA_l

D12335_PEA_1

T47019

S56200_PEA_l

ChipOvary

Dl 1793

Dl 1495

T78438

HSCDC2

HUMPROTP

HSAPHOL

HUMPAX8A

N23262

HSHE4MR_PEA_1

HSMRPl

Z38148_PEA_1

Z43749_PEA_1

Z39337_PEA_2_PEA_

ChipBreast

Z39788

HUMCAlXIA

Z44103

R36629

R10078

WOl 871

R20779

R49883

R14741

HSCDC2

T11628_PEA_1

ChipLungAll

Z39788

HUMCAlXIA

F10611

Z45766

N69694 Z40569

M85976

T07775

Z44103

HUMPFK

WOl 871

H41850

HSB6PR

T86235

AA318609

R14741

HUMGRP5E

Z44716

T78438

HUMDNAPOLD

HSCDC2

HUMPROTP

Tl 1832

HUMTLEII

M62246

M79217_PEA_1

M62096_PEA_l

F09066

T99080_PEA_4

HUMHOXAB_PEA_1

Z43749_PEA_1

ChipLungAC

HUMCAlXIA

Z44103

HUMPFK

Dl 1793

T86235

T78438

T11628_PEA_1

ChipLungSCC

Z39788

F10611

Z45766

N69694

Z40569

M85976

T07775

R10078

HUMPFK WOl 871

T86235

AA318609

Rl 4741

HUMGRP5E

Z44716

HUMDNAPOLD

HSCDC2

HSCYTK

HUMPROTP

Tl 1832

HUMTLEII

M62246

HUMRAP IGAP

M79217_PEA_1

M62096_PEA_l

F09066

T99080_PEA_4

HUMHOXABJPEAJ

Z43749_PEA_1

ChipLungSQ

HUMCAlXIA

HUMKERK5A

F10611

Z44103

WOl 871

H41850

HSB6PR

T86235

AA318609

HSCDC2

Tl 1832

M62246

HUMCEA_PEA_1

S56200_PEA_l

TAA_GEN

AA056634

HUMCAlXIA

HUMKER56K

HSBMYB

HUMKERK5A

N50847

T51634

F10611 Z45766

N69694

Z40569

M85976

D12232

R36629

Rl 0078

HUMPFK

W01871

R60180

M78378

AA604379

HUMMPP2X

R20779

HSB6PR

Dl 1793

T55968

T86235

Dl 1495

HSU03911

Z19129

HSKERELP

Z44716

Z40494

HSAE2

T78438

T93947

HUMASHlA

T66935

R34204

D12392

HUMDNAPOLD

T78346

Z21997

HSCDC2

HUMPKM2L

HSCYTK

W25389

Z25166

T41334

Tl 1832

M79251

HUMETR103

F13779

AA563651

T06117 HUMSTPKl 3

R82331

HUMCYCB

D11717

T07560

HUMPAX8A

Z20721

Tl 9724

AA091457

HUMKERMII

R34187

HUMGGTX_PEA_1

HUMCEA_PEA_1

R00317_PEA_l

D12335_PEA_1

T46984_PEA_1

Z38219JPEAJ

Z28497_PEA_1

HSRR2SS_PEA_1

HUMHOXAB_PEA_1

Z43749_PEA_1

HSLDHAR_PEA_3

R31990_PEA_l

HSUDGM_PEA_1

AA056634

HUMCAlXIA

HSBMYB

N50847

T51634

F10611

Z45766

N69694

Z40569

M85976

D12232

R36629

Rl 0078

HUMPFK

W01871

R60180

M78378

AA604379

HUMMPP2X

R20779

T49823

Dl 1793 T55968

T86235

Dl 1495

HSU03911

AA318609

HSKERELP

Z44716

Z40494

T78438

T93947

HUMASHlA

T66935

R34204

D12392

HUMDNAPOLD

T78346

Z21997

HSCDC2

T86345

HUMPKM2L

W25389

Z25166

T11832

M79251

F13779

AA563651

HUMSTPKl 3

R82331

HUMCYCB

R17570

D11717

HUMPAX8A

Z20721

Tl 9724

M62246

AA091457

R34187

HUMCEA_PEA_1

R00317_PEA_l

D12335_PEA_1

T46984_PEA_1

Z38219_PEA_1

Z28497_PEA_1

HSRR2SS_PEA_1

HUMHOXAB_PEA_1

Z43749 PEA 1 Z39337_PEA_2_PEA_1 R31990_PEA_l HSUDGM PEA 1

TAAJDVA

HSBMYB

Dl 1793

T78438

Tl 0374

T78346

HUMPKM2L

Z25166

T59832

R82331

M78445

M77903

HUMPAX8A

Tl 9724

HUMKERMII

HSHE4MRJPEA 1

HSMRPl

T46984_PEA_1

Z38219_PEA_1

HSLDHAR PEA 3

TAA_PRO

R47363

M78378

T07259

HSEF2

Dl 1495

HSAE2

M85927

R52151

Z19214

HUMETR103

TAA_MAM

Z19204

HUMBFN15K

T78438

T78346

Z21997

HSCDC2 T59832

HUMCYCB

T07560

Z20721

T46984_PEA_1

TAA COL

Tl 0476

M85976

D12232

Z38489

Dl 1495

Z19129

Z19214

D11717

R00317_PEA_l

Z38219_PEA_1

Z28497JPEAJ

HSRR2SS_PEA_1

TAA_LUN

T08538

HUMCAlXIA

T51634

Z44103

HUMTIAlE

M78378

R20779

R01445

HUMASHlA

Z21997

AA563651

HUMSTPK13

M62117

D12335_PEA_1

Z38219_PEA_1

HSRR2SS_PEA_1

TAA_BLADDER

HUMKERK5A

R36629

HSKERELP

HUMKERMII TAA_KIDNEY

HSBMYB

R60180

M78378

T41334

Z19214

HUMCYCB

T19724

HUMVWFJPEAJ

D12335_PEA_1

TAAJJTERUS

HSBMYB

T51634

D12232

R36629

R60180

AA604379

HUMMPP2X

Dl 1495

HSKERELP

R34204

T78346

Z21997

HUMPKM2L

T41334

Z19214

HUMSTPK13

R82331

HUMCYCB

M77903

HUMPAX8A

T19724

M62189

HSHE4MR_PEA_1

Z43749_PEA_1

TAA_PANCREAS

AA056634

R47363

HUMKER56K

HSBMYB

HUMKERK5A

N50847

T51634 R60180

Dl 1793

T55968

HSKERELP

Z40494

Z21997

HUMPKM2L

T59832

HUMSTPKl 3

HUMCYCB

T07560

HUMKERMII

HSTCRT3E

HUMVWF_PEA_1

HUMCEA_PEA_1

Rl 3007

HUMMHGM

T47019

S95936_PEA_1

T46984_PEA_1

HSRR2SS_PEA_1

TAA_BRAIN

AA056634

HSBMYB

T51634

Z45766

Z40569

M85976

R36629

Rl 0078

R60180

HSCD44E

AA604379

HUMMPP2X

R49883

T55968

T86235

HUMIFNl 5K

Z40494

HSAE2

T93947

HUMASHlA

M85927

HUMDNAPOLD T78346

Z21997

HSCDC2

W25389

HUMETRl 03

T59832

R82331

HUMCYCB

D11717

T07560

M78001

R34187

D12335_PEA_1

HUMMHGM

H8RR2SS_PEA_1

TAAjSKIN

HSBMYB

T51634

R10078-

R60180

M78378

AA604379

HUMMPP2X

T49823

T55968

T86235

Z40494

D12392

HUMDNAPOLD

Z21997

F13779

R20420

HUMSTPKl 3

R82331

HUMCYCB

Tl 9724

Z38219JPEAJ

HSRR2SS_PEA_1

TAA_STOMACH

T51634

HSCD44E

R34204

T86345 HUMPKM2L

Z25166

D11717

D12335_PEA_1

HSRR2SSJPEA 1

Z39337_PEA_2_PEA_

HSLDHAR PEA 3

DESCRIPTION FOR CLUSTER Z45766

Cluster Z45766 features 17 transcript(s) and 37 segment(s) of interest, the names for which are given in Tables 1 and 2, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3.

Table 1 - Transcripts of interest

TranscriptName

Z45766 TO

Z45766 Tl

Z45766 T3

Z45766 T7

Z45766 T9

Z45766 TlO

Z45766 TIl

Z45766 T12

Z45766 T15

Z45766 T16

Z45766 T17

Z45766 T18

Z45766 T21

Z45766 T22

Z45766 T25

Z45766 T27

Z45766 T28

Table2 -Segmentsofinterest

SegmentName

Z45766 node 4

Table 3 - Proteins of interest

These sequences are variants of the known protein G2 and S phase expressed protein 1 (SwissProt accession identifier GTSEJHUMAN; known also according to the synonyms B99 homolog), referred to herein as the previously known protein. Protein G2 and S phase expressed protein 1 is known or believed to have the following function(s): May be involved in p53- induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. The sequence for protein G2 and S phase expressed protein 1 is given at the end of the application, as "G2 and S phase expressed protein 1 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4.

Table 4 - Amino acid mutations for Known Protein

Protein G2 and S phase expressed protein 1 localization is believed to be Cytoplasmic. Associated with microtubules.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: G2 phase of mitotic cell cycle; DNA damage response, induction of cell arrest by p53; microtubule-based process, which are annotation(s) related to Biological Process; and cytoplasmic microtubule, which are annotation(s) related to Cellular Component. The GO assignment relies on infoπnation from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http ://www.ncbi .nlm .nih.gov/proj ects/LocusLink/>.

Cluster Z45766 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 3 below refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 3 and Table 5. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 5 - Normal tissue distribution

Uterus 45

Table 6 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z45766 features 37 segment(s), which were listed in Table 2 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z45766_node_4 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T28. Table 7 below describes the starting and ending position of this segment on each transcript.

Table 7 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P18.

Segment cluster Z45766_node_8 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766JN8, Z45766_T21, Z45766_T22 and Z45766_T25. Table 8 below describes the starting and ending position of this segment on each transcript.

Table 8 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P2. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766_P12, Z45766JP8, Z45766JP14 and Z45766JP16, since it is in the coding region for the corresponding transcript. Segment cluster Z45766_node_9 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T18, Z45766_T21 and Z45766_T22. Table 9 below describes the starting and ending position of this segment on each transcript.

Table 9 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766_P19, Z45766_P2,

Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766JP12, Z45766_P8 and Z45766 P14.

Segment cluster Z45766_node_12 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T18, Z45766_T21 and Z45766_T22. Table 10 below describes the starting and ending position of this segment on each transcript. Table 10 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766_P19, Z45766JP2, Z45766_P4, Z45766_P5, Z45766JP6, Z45766_P7, Z45766_P9, Z45766_P12, Z45766_P8 and Z45766 P14.

Segment cluster Z45766_node_16 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T15, Z45766_T18, Z45766_T21, Z45766_T22 and Z45766_T28. Table 11 below describes the starting and ending position of this segment on each transcript.

Table 11 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766JP18. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766JM, Z45766_P5, Z45766_P6, Z45766_P9, Z45766_P12, Z45766_P8 and Z45766_P14, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766jnode_17 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T28. Table 12 below describes the starting and ending position of this segment on each transcript.

Table 12 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766JP18.

Segment cluster Z45766_node_19 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T18, Z45766_T21 and Z45766_T22. Table 13 below describes the starting and ending position of this segment on each transcript.

Table 13 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766_P12, Z45766_P8 and Z45766 P14.

Segment cluster Z45766_node_22 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766JN1, Z45766_T12, Z45766_T18, Z45766_T21 and Z45766_T22. Table 14 below describes the starting and ending position of this segment on each transcript.

Table 14 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P7. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P12, Z45766_P8 and Z45766_P14, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node__24 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T21 and Z45766_T22. Table 15 below describes the starting and ending position of this segment on each transcript.

Table 15 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766JP8. This segment can also be found in the following protein(s): Z45766_P14, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_28 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766 T16. Table 16 below describes the starting and ending position of this segment on each transcript.

Table 16 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766JP10.

Segment cluster Z45766_node_30 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T17 and Z45766_T27. Table 17 below describes the starting and ending position of this segment on each transcript.

Table 17 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766_P11 and Z45766_P17.

Segment cluster Z45766_node_33 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T16, Z45766_T17, Z45766_T18 and Z45766_T27. Table 18 below describes the starting and ending position of this segment on each transcript.

Table 18 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 19. Table 19 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P5 and Z45766_P7. This segment can also be found in the following protein(s): Z45766JP19, Z45766_JP2, Z45766_P4, Z45766_P6, Z45766_P10, Z45766_P11, Z45766_P12 and Z45766_P17, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_34 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T27. Table 20 below describes the starting and ending position of this segment on each transcript.

Table 20 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766_P17.

Segment cluster Z45766_node_37 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7,

Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T16, Z45766_T17 and Z45766_T18. Table

21 below describes the starting and ending position of this segment on each transcript.

Table 21 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P5 and Z45766_P7. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766_P6, Z45766_P10, Z45766_P11 and

Z45766_P12, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_39 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T18. Table 22 below describes the starting and ending position of this segment on each transcript.

Table 22 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766_P12.

Segment cluster Z45766_node_42 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T12, Z45766_T16 and Z45766_T17. Table 23 below describes the starting and ending position of this segment on each transcript.

Table 23 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P4, Z45766_P5 and Z45766_P7. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766_P10 and Z45766_P11, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_44 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7,

Z45766_T9, Z45766_T10, Z45766_T12, Z45766_T16 and Z45766_T17. Table 24 below describes the starting and ending position of this segment on each transcript.

Table 24 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of tanscript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766JP4, Z45766_P5 and Z45766_P7. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766_P10 and Z45766_P11, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_45 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T16 and Z45766_T17. Table 25 below describes the starting and ending position of this segment on each transcript.

Table 25 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P7, Z45766_P10 and Z45766JP11. This segment can also be found in the following protein(s): Z45766_P6, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_46 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_ T11, Z45766_T12, Z45766_T16 and Z45766_T17. Table 26 below describes the starting and ending position of this segment on each transcript.

Table 26 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766JP19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766JP6, Z45766_P7, Z45766_P10 and Z45766_Pl l.

Segment cluster Z45766_node_47 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T16 and Z45766_T17. Table 27 below describes the starting and ending position of this segment on each transcript.

Table 27 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766JP7, Z45766_P10 and Z45766JP11. This segment can also be found in the following protein(s): Z45766_P9, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_51 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T16, Z45766_T17 and Z45766_T25. Table 28 below describes the starting and ending position of this segment on each transcript.

Table 28 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 29.

Table 29 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766JP7, Z45766_P9, Z45766_P10 and Z45766_P11. This segment can also be found in the following protein(s): Z45766__P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_53 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T16, Z45766_T17 and Z45766_T25. Table 30 below describes the starting and ending position of this segment on each transcript.

Table 30 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766_P10, Z45766_P11 and Z45766_P16.

Segment cluster Z45766_node_55 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766JN 1, Z45766_T12, Z45766_T15, Z45766_T16, Z45766_T17 and Z45766_T25. Table 31 below describes the starting and ending position of this segment on each transcript.

Table 31 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766_P10, Z45766_P11 and Z45766_P16.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are i innrcVllπurdlfevdi i inn a a s craepiaϋrrnattpe H dpessrc.rirmpttiinonn. Segment cluster Z45766_node_0 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T18, Z45766_T21, Z45766_T22 and Z45766_T25. Table 32 below describes the starting and ending position of this segment on each transcript.

Table 32 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766_P12, Z45766_P8, Z45766_P14 and Z45766_P16.

Segment cluster Z45766_node_2 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T18, Z45766JT21, Z45766_T22 and Z45766_T25. Table 33 below describes the starting and ending position of this segment on each transcript.

Table 33 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P2. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766_P12, Z45766_P8, Z45766_P14 and Z45766_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_6 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T18, Z45766_T21, Z45766_T22 and Z45766_T25. Table 34 below describes the starting and ending position of this segment on each transcript.

Table 34 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766_P19, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766_P12, Z45766_P8, Z45766_P14 and Z45766_P16.

Segment cluster Z45766_node_15 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T28. Table 35 below describes the starting and ending position of this segment on each transcript.

Table 35 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P18.

Segment cluster Z45766_node_20 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T18, Z45766_T21 and Z45766JT22. Table 36 below describes the starting and ending position of this segment on each transcript.

Table 36 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766JP19, Z45766JP2, Z45766_P4, Z45766_P6, Z45766_P7, Z45766_P9, Z45766JP12, Z45766_P8 and Z45766JP14.

Segment cluster Z45766_node_21 according to the present invention can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T11, Z45766_T12, Z45766_T18, Z45766_T21 and Z45766_T22. Table 37 below describes the starting and ending position of this segment on each transcript.

Table 37 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766JP4, Z45766_P6, Z45766_P7, Z45766_P12, Z45766_P8 and Z45766_P14.

Segment cluster Z45766_node_23 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be W

81 found in the following transcript(s): Z45766_T21. Table 38 below describes the starting and ending position of this segment on each transcript.

Table 38 - Segment location on transcripts

This segment can be found in the following protein(s): Z45766JP8.

Segment cluster Z45766_node_25 according to the present invention can be found in the following transcript(s): Z45766_T21 and Z45766_T22. Table 39 below describes the starting and ending position of this segment on each transcript. Table 39 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766JP8 and Z45766_P14.

Segment cluster Z45766_node_26 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): Z45766_T21 and Z45766_T22. Table 40 below describes the starting and ending position of this segment on each transcript.

Table 40 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z45766_P8 and Z45766_P14. Segment cluster Z45766_node_31 according to the present invention is supported by 28 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T16, Z45766_T17, Z45766_T18 and Z45766_T27. Table 41 below describes the starting and ending position of this segment on each transcript.

Table 41 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P5 and Z45766_P7. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P6, Z45766_P10, Z45766_P11, Z45766_P12 and Z45766_P17, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_38 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T16, Z45766_T17 and Z45766_T18. Table

42 below describes the starting and ending position of this segment on each transcript. Table 42 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P5 and Z45766_P7. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766_P6, Z45766_P10, Z45766_P11 and

Z45766_P12, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_41 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7,

Z45766_T9, Z45766_T10, Z45766_T12, Z45766_T16 and Z45766_T17. Table 43 below describes the starting and ending position of this segment on each transcript.

Table 43 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P5 and Z45766_P7. This segment can also be found in the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P10 and Z45766JP11, since it is in the coding region for the corresponding transcript.

Segment cluster Z45766_node_50 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T16, Z45766_T17 and Z45766_T25. Table 44 below describes the starting and ending position of this segment on each transcript.

Table 44 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766JP7, Z45766_P9, Z45766JP10 and Z45766JP11. This segment can also be found in the following protein(s): Z45766_P16, since it is in the coding region for the corresponding transcript. Segment cluster Z45766_node_52 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z45766_T0, Z45766_T1, Z45766_T3, Z45766_T7, Z45766_T9, Z45766_T10, Z45766_T11, Z45766_T12, Z45766_T15, Z45766_T16, Z45766_T17 and Z45766_T25. Table 45 below describes the starting and ending position of this segment on each transcript.

Table 45 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z45766_P19, Z45766_P2, Z45766_P4, Z45766_P5, Z45766_P6, Z45766_P7, Z45766_P9, Z45766_P10, Z45766_P11 and Z45766_P16.

DESCRIPTION FOR CLUSTER AA436634

Cluster AA436634 features 1 transcript(s) and 1 segment(s) of interest, the names for which are given in Tables 46 and 47, respectively, the sequences themselves are given at the end of the application..

Table 46 - Transcripts of interest

Transcript Name

AA436634 TO Table 47 - Segments of interest

Segment Name

AA436634 node 0

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster AA436634. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y-axis of the Figure 4 below refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 4, concerning the number of heart- specific clones in libraries/sequences.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non-heart ESTs, which was found to be 39.1; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 74; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be l.lOE-05.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher fevel in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 39.1, which clearly supports specific expression in heart tissue. As noted above, cluster AA436634 features 1 segment(s), which were listed in Table 47 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster AA436634_node_0 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA436634_T0. Table 49 below describes the starting and ending position of this segment on each transcript.

Table 49 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER AA604379

Cluster AA604379 features 4 transcript(s) and 22 segment(s) of interest, the names for which are given in Tables 50 and 51, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 52.

Table 50 - Transcripts of interest

Transcript Name

AA604379 T4

AA604379 T5

AA604379 T6

AA604379 TlO

Table 51 - Segments of interest

Table 52 - Proteins of interest

Cluster AA604379 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 5 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 5 and Table 53. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant rumors, a mixture of malignant rumors from different

Table 53 - Normal tissue distribution

As noted above, cluster AA604379 features 22 segment(s), which were listed in Table 51 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster AA604379_node_2 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 55 below describes the starting and ending position of this segment on each transcript.

Table 55 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379_P3, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_14 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 56 below describes the starting and ending position of this segment on each transcript.

Table 56 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379_P3, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_19 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T5 and AA604379_T10. Table 57 below describes the starting and ending position of this segment on each transcript.

Table 57 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P3. This segment can also be found in the following protein(s): AA604379_P4, since it is in the coding region for the corresponding transcript. Segment cluster AA604379_node_21 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA6O4379_T1O. Table 58 below describes the starting and ending position of this segment on each transcript.

Table 58 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA6O4379_P1 and AA604379_P3. This segment can also be found in the following protein(s): AA604379_P4, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_22 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 59 below describes the starting and ending position of this segment on each transcript.

Table 59 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA6O4379_P1, AA604379_P3 and AA604379_P4. Segment cluster AA604379_node_25 according to the present invention is supported by

44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 60 below describes the starting and ending position of this segment on each transcript.

Table 60 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379JP1, AA604379JP3 and AA604379_P4.

Segment cluster AA604379_node_27 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 61 below describes the starting and ending position of this segment on each transcript.

Table 61 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA6O4379_P1, AA604379_P3 and AA604379_P4. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster AA604379_node_0 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 62 below describes the starting and ending position of this segment on each transcript.

Table 62 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379_P3, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_3 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 63 below describes the starting and ending position of this segment on each transcript. Table 63 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379_P3, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_4 according to the present invention can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 64 below describes the starting and ending position of this segment on each transcript.

Table 64 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379_P3, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_5 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5 and AA604379_T6. Table 65 below describes the starting and ending position of this segment on each transcript.

Table 65 - Segment location on transcripts

This segment can be found in the following protein(s): AA6O4379_P1 and

AA604379 P3.

Segment cluster AA604379_node_6 according to the present invention can be found in the following transcript(s): AA604379_T4, AA604379_T5 and AA604379_T6. Table 66 below describes the starting and ending position of this segment on each transcript.

Table 66 - Segment location on transcripts

This segment can be found in the following protein(s): AA6O4379_P1 and AA604379_P3.

Segment cluster AA604379_node_10 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 67 below describes the starting and ending position of this segment on each transcript.

Table 67 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379_P3, since it is in the coding region for the corresponding transcript, i

Segment cluster AA604379_node_l 1 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 68 below describes the starting and ending position of this segment on each transcript.

Table 68 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379 P3, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_12 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 69 below describes the starting and ending position of this segment on each transcript.

Table 69 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379_P3, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_13 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379 T10. Table 70 below describes the starting and ending position of this segment on each transcript.

Table 70 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P4. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379_P3, since it is in the coding region for the corresponding transcript. Segment cluster AA604379_node_16 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 71 below describes the starting and ending position of this segment on each transcript.

Table 71 - Segment location on transcripts

This segment can be found in the following protein(s): AA6O4379_P1, AA604379_P3 and AA604379 P4.

Segment cluster AA604379_node_18 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T5, AA604379_T6 and AA604379_T10. Table 72 below describes the starting and ending position of this segment on each transcript.

Table 72 - Segment location on transcripts

This segment can be found in the following protein(s): AA604379_P3 and AA604379_P4.

Segment cluster AA604379_node_20 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can W

100 be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 73 below describes the starting and ending position of this segment on each transcript.

Table 73 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA604379_P3. This segment can also be found in the following protein(s): AA6O4379_P1 and AA604379JP4, since it is in the coding region for the corresponding transcript.

Segment cluster AA604379_node_j23 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 74 below describes the starting and ending position of this segment on each transcript.

Table 74 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): AA6O4379_P1, AA604379_P3 and AA604379_P4. Segment cluster AA604379_node_24 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 75 below describes the starting and ending position of this segment on each transcript.

Table 75 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA6O4379_P1, AA604379_P3 and AA604379_P4.

Segment cluster AA604379_node_26 according to the present invention can be found in the following transcript(s): AA604379_T4, AA604379_T5, AA604379_T6 and AA604379_T10. Table 76 below describes the starting and ending position of this segment on each transcript.

Table 76 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA6O4379_P1, AA604379_P3 and AA604379_P4.

DESCRIPTION FOR CLUSTER C03218 Cluster C03218 features 6 transcript(s) and 7 segment(s) of interest, the names for which are given in Tables 77 and 78, respectively, the sequences themselves are given at the end of the application.

Table 77 - Transcripts of interest

Transcript Name

C03218 TO

C03218 Tl

C03218_ T2

C03218 T3

C03218 T4

C03218 T5

Table 78 - Segments of interest

Segment Name

C03218 node 0

C03218 node 7

C03218 node 8

C03218 node 10

C03218 node 2

C03218 node 4

C03218 node 5

The heart-selective diagnostic marker prediction engine provided the following results with regard to cluster C03218. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of the first Figure 6 below refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histogram in

Figure 6, concerning the number of heart- specific clones in libraries/sequences.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in no n- heart ESTs, which was found to be 130.1; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 96.2; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 1.70E-08.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 130.1, which clearly supports specific expression in heart tissue.

As noted above, cluster C03218 features 7 segment(s), which were listed in Table 78 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster C03218_node_0 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03218_T0, CO3218_T1, C03218_T2, C03218_T3, C03218_T4 and C03218_T5. Table 80 below describes the starting and ending position of this segment on each transcript. Table 80 - Segment location on transcripts

C03218 T5 174

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster C03218_node_7 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03218_T0, C03218_T1, C03218_T2 and C03218_T3. Table 81 below describes the starting and ending position of this segment on each transcript.

Table 81 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster C03218_node_8 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03218_T0, CO3218_T1 and C03218_T2. Table 82 below describes the starting and ending position of this segment on each transcript.

Table 82 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster C03218_node_10 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03218_T3, C03218_T4 and C03218_T5. Table 83 below describes the starting and ending position of this segment on each transcript.

Table 83 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster C03218_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03218_T2. Table 84 below describes the starting and ending position of this segment on each transcript.

Table 84 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster C03218_node_4 according to the present invention can be found in the following transcript(s): CO3218_T1, C03218_T2 and C03218_T3. Table 85 below describes the starting and ending position of this segment on each transcript.

Table 85 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster C03218_node_5 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03218_T0, CO3218_T1, C03218_T2, C03218_T3 and C03218_T5. Table 86 below describes the starting and ending position of this segment on each transcript.

Table 86 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER C03950

Cluster C03950 features 5 transcript(s) and 34 segment(s) of interest, the names for which are given in Tables 87 and 88, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 89.

Table 87 - Transcripts of interest

Transcript Name

C03950 TO

C03950 T7

C03950 T8

C03950 T9

C03950 T13

Table 88 - Segments of interest SegmentName

C03950 node 4

C03950 node 8

C03950 node 13

C03950 node 25

C03950 node 29

C03950 node 36

C03950 node 47

C03950 node 48

C03950 node 57

C03950 node 63

C03950 node 67

C03950 node 71

C03950 node 77

C03950 node 0

C03950 node 1

C03950 node 2

C03950 node 6

C03950 node 11

C03950 node 15

C03950 node 17

C03950 node 21

C03950 node 23

C03950 node 32

C03950 node 34

C03950 node 38

C03950 node 40

C03950 node 42

C03950 node 45

C03950 node 50

C03950 node 59

C03950 node 61

C03950 node 65

C03950 node 69

C03950 node 73

Table 89 - Proteins of interest

I C03950 P14 I C03950 TO I

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster C03950. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of the first Figure 7 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histogram in

Figure 7, concerning the number of heart- specific clones in libraries/sequences.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 9.5; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 3.7; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be l.40E-03.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 9.5, which clearly supports specific expression in heart tissue. As noted above, cluster C03950 features 34 segment(s), which were listed in Table 88 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster C03950_node_4 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T7, C03950_T8, C03950_T9 and C03950_T13. Table 90 below describes the starting and ending position of this segment on each transcript.

Table 90 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P7, C03950_P8, C03950_P9 and C03950_P13.

Segment cluster C03950_node_8 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0. Table 91 below describes the starting and ending position of this segment on each transcript.

Table 91 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14.

Segment cluster C03950_node_13 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T13. Table 92 below describes the starting and ending position of this segment on each transcript.

Table 92 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P13.

Segment cluster C03950_node_25 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950 T0, C03950_T7, C03950_T8 and C03950_T9. Table 93 below describes the starting and ending position of this segment on each transcript.

Table 93 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7, C03950_P8 and C03950_P9.

Segment cluster C03950_node_29 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950JT7, C03950_T8 and C03950_T9. Table 94 below describes the starting and ending position of tills segment on each transcript.

Table 94 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7, C03950_P8 and C03950_P9.

Segment cluster C03950_node_36 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 95 below describes the starting and ending position of this segment on each transcript.

Table 95 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7, C03950 P8 and C03950 P9.

Segment cluster C03950_node_47 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 96 below describes the starting and ending position of this segment on each transcript.

Table 96 - Segment location on transcripts

This segment can be found in the following protein(s): C03950 P14, C03950_P7, C03950 P8 and C03950 P9. Segment cluster C03950__node_48 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T9. Table 97 below describes the starting and ending position of this segment on each transcript.

Table 97 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P9.

Segment cluster C03950_node_57 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T7. Table 98 below describes the starting and ending position of this segment on each transcript.

Table 98 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P7.

Segment cluster C03950_node_63 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0 and C03950_T8. Table 99 below describes the starting and ending position of this segment on each transcript.

Table 99 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14 and C03950_P8.

Segment cluster C03950_node_67 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T8. Table 100 below describes the starting and ending position of this segment on each transcript.

Table 100 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P8.

Segment cluster C03950_node_71 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0. Table 101 below describes the starting and ending position of this segment on each transcript.

Table 101 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14.

Segment cluster C03950_node_77 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0. Table 102 below describes the starting and ending position of this segment on each transcript.

Table 102 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster C03950_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T13. Table 103 below describes the starting and ending position of this segment on each transcript.

Table 103 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P13.

Segment cluster C03950_node_l according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T7, C03950_T8 and C03950_T9. Table 104 below describes the starting and ending position of this segment on each transcript.

Table 104 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P7, C03950_P8 and C03950 P9. Segment cluster C03950_node_2 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T7, C03950_T8, C03950_T9 and C03950_T13. Table 105 below describes the starting and ending position of this segment on each transcript.

Table 105 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P7, C03950_P8, C03950_P9 and C03950_P13.

Segment cluster C03950_node_6 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T7, C03950_T8, C03950_T9 and C03950_T13. Table 106 below describes the starting and ending position of this segment on each transcript.

Table 106 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P7, C03950_P8, C03950 P9 and C03950 P13.

Segment cluster C03950_node_l 1 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8, C03950_T9 and C03950_T13. Table 107 below describes the starting and ending position of this segment on each transcript.

Table 107 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7,

C03950_P8, C03950JP9 and C03950_P13.

Segment cluster C03950_node_15 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following franscript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 108 below describes the starting and ending position of this segment on each transcript.

Table 108 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7, C03950 P8 and C03950 P9.

Segment cluster C03950_node_17 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 109 below describes the starting and ending position of this segment on each transcript.

Table 109 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950__P7, C03950JP8 and C03950_P9.

Segment cluster C03950_node_21 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 110 below describes the starting and ending position of this segment on each transcript.

Table 110 - Segment location on transcripts

This segment can be found in the following ρrotein(s): C03950_P14, C03950_P7, C03950 P8 and C03950 P9.

Segment cluster C03950_node_23 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 111 below describes the starting and ending position of this segment on each transcript.

Table 111 - Segment location on transcripts

C03950 T9 787 885

This segment can be found in the following protein(s): C03950J^>14, C03950_P7, C03950_P8 and C03950J^>9.

Segment cluster C03950_node_32 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 112 below describes the starting and ending position of this segment on each transcript.

Table 112 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7, C03950 P8 and C03950 P9.

Segment cluster C03950_node_34 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 113 below describes the starting and ending position of this segment on each transcript.

Table 113 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950JP7, C03950 P8 and C03950 P9. Segment cluster C03950_node_38 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 114 below describes the starting and ending position of this segment on each transcript.

Table 114 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7, C03950_P8 and C03950_P9.

Segment cluster C03950_node_40 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): <D3950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 115 below describes the starting and ending position of this segment on each transcript.

Table 115 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7, C03950 P8 and C03950 P9.

Segment cluster C03950_node_42 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 116 below describes the starting and ending position of this segment on each transcript.

Table 116 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950JP7,

C03950 P8 and C03950 P9.

Segment cluster C03950_node_45 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7, C03950_T8 and C03950_T9. Table 117 below describes the starting and ending position of this segment on each transcript.

Table 117 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7, C03950 P8 and C03950 P9.

Segment cluster C03950_node_50 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0, C03950_T7 and C03950_T8. Table 118 below describes the starting and ending position of this segment on each transcript.

Table 118 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14, C03950_P7 and C03950 P8.

Segment cluster C03950_node_59 according to the present invention is supported by 0 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0 and C03950_T8. Table 119 below describes the starting and ending position of this segment on each transcript.

Table 119 - Segment location on transcripts

This segment can be found in the following protein(s): C03950 P14 and C03950_P8.

Segment cluster C03950_node_61 according to the present invention is supported by 0 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0 and C03950_T8. Table 120 below describes the starting and ending position of this segment on each transcript.

Table 120 - Segment location on transcripts

This segment can be found in the following protein(s): C03950 P14 and C03950_P8. Segment cluster C03950_node__65 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0 and C03950_T8. Table 121 below describes the starting and ending position of this segment on each transcript.

Table 121 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14 and C03950_P8.

Segment cluster C03950_node_69 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950 T0. Table 122 below describes the starting and ending position of this segment on each transcript.

Table 122 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14.

Segment cluster C03950_node_73 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): C03950_T0. Table 123 below describes the starting and ending position of this segment on each transcript.

Table 123 - Segment location on transcripts

This segment can be found in the following protein(s): C03950_P14. DESCRIPTION FOR CLUSTER Dl 1495

Cluster Dl 1495 features 6 transcript(s) and 20 segment(s) of interest, the names for which are given in Tables 1 and 2, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 126.

Table 124 - Transcripts of interest

Table 125 - Segments of interest

Table 126 - Proteins of interest

These sequences are variants of the known protein NAD (SwissProt accession identifier NQO1_HUMAN; known also according to the synonyms P; EC 1.6.99.2; Quinone reductase 1; QRl; DT-diaphorase; DTD; Azoreductase; Phylloquinone reductase; Menadione reductase), referred to herein as the previously known protein.

Protein NAD is known or believed to have the following function(s): The en2yme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma- carboxylation of glutamate residues in prothrombin synthesis. The sequence for protein NAD is given at the end of the application, as "NAD amino acid sequence". Known polymorphisms for this sequence are as shown in Table 127.

Table 127 -Amino acid mutations for Known Protein

Protein NAD localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: electron transport; xenobiotic metabolism; nitric oxide biosynthesis; synaptic transmission, cholinergic; detoxification response, which are annotation(s) related to Biological Process; NAD(P)H dehydrogenase (quinone); cytochrome b5 reductase; oxidoreductase, which are annotation(s) related to Molecular Function; and cytoplasm, which are annotation(s) related to Cellular Component.

The QD assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nkn.nih.gov/projects/LocusLink/>.

Cluster Dl 1495 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 8 below refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 8 and Table 128. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: colorectal cancer, epithelial malignant tumors, a mixture of malignant tumors from different tissues, hepatocellular carcinoma, prostate cancer and uterine malignancies.

Table 128 - Nonnal tissue distribution

Table 129 - P values and ratios for expression in cancerous tissue

As noted above, cluster Dl 1495 features 20 segment(s), which were listed in Table 125 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster D11495_node_0 according to the present invention is supported by 203 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T18 and D11495_T19. Table 130 below describes the starting and ending position of this segment on each transcript.

Table 130 - Segment location on transcripts

This segment can be found in the following protein(s): D11495JP4, D11495_P13 and D11495JP14.

Segment cluster D11495_node_5 according to the present invention is supported by 238 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T18 and D11495_T19. Table 131 below describes the starting and ending position of this segment on each transcript.

Table 131 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P4, D11495_P13 and Dl 1495 P14.

Segment cluster D11495_node_l l according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T19. Table 132 below describes the starting and ending position of this segment on each transcript. Table 132 - Segment location on transcripts

This segment can be found in the following protein(s): Dl 1495_P14.

Segment cluster D11495_node_21 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T17 and D11495_T20. Table 133 below describes the starting and ending position of this segment on each transcript.

Table 133 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Dl 1495_node_23 according to the present invention is supported by 251 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T17 and D11495_T20. Table 134 below describes the starting and ending position of this segment on each transcript.

Table 134 - Segment location on transcripts

This segment can be found in the following protein(s): Dl 1495_P4. Segment cluster D11495_node_25 according to the present invention is supported by 142 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6 and D11495_T17. Table 135 below describes the starting and ending position of this segment on each transcript.

Table 135 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1495_P4.

Segment cluster D11495_node_27 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T18. Table 136 below describes the starting and ending position of this segment on each transcript.

Table 136 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P13.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster D11495_node_l according to the present invention can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T18 and D11495_T19. Table 137 below describes the starting and ending position of this segment on each transcript. Table 137 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P4, D11495_P13 and D11495_P14.

Segment cluster D11495_node_3 according to the present invention can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T18 and D11495_T19. Table 138 below describes the starting and ending position of this segment on each transcript.

Table 138 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P4, D11495_P13 and Dl 1495 P14.

Segment cluster D11495_node_4 according to the present invention is supported by 224 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T18 and D11495_T19. Table 139 below describes the starting and ending position of this segment on each transcript.

Table 139 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P4, D11495_P13 and D11495_P14.

Segment cluster D11495_node_7 according to the present invention is supported by 212 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T18 and D11495_T19. Table 140 below describes the starting and ending position of this segment on each transcript.

Table 140 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P4, D11495_P13 and Dl 1495 P14.

Segment cluster D11495_node_8 according to the present invention can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T18 and D11495_T19. Table 141 below describes the starting and ending position of this segment on each transcript.

Table 141 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P4, D11495_P13 and D11495 P14. Segment cluster D11495_node_9 according to the present invention is supported by 196 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6, D11495_T11, D11495_T18 and D11495_T19. Table 142 below describes the starting and ending position of this segment on each transcript.

Table 142 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P4, D11495_P13 and Dl 1495 P14.

Segment cluster D11495_node_10 according to the present invention can be found in the following transcript(s): D11495_T6, D11495_T11, D11495 T18 and D11495_T19. Table 143 below describes the starting and ending position of this segment on each transcript.

Table 143 - Segment location on transcripts

This segment can be found in the following protein(s): D11495_P4, D11495_P13 and D11495 P14.

Segment cluster D11495_node_13 according to the present invention can be found in the following transcript(s): D11495_T6 and D11495_T11. Table 144 below describes the starting and ending position of this segment on each transcript.

Table 144 - Segment location on transcripts

This segment can be found in the following protein(s): Dl 1495_P4.

Segment cluster D11495_node_14 according to the present invention is supported by 174 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6 and D11495_T11. Table 145 below describes the starting and ending position of this segment on each transcript.

Table 145 - Segment location on transcripts

This segment can be found in the following protein(s): Dl 1495_P4.

Segment cluster D11495_node_15 according to the present invention is supported by 184 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11495_T6 and D11495_T11. Table 146 below describes the starting and ending position of this segment on each transcript.

Table 146 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 147.

Table 147 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): Dl 1495_P4.

Segment cluster D11495_node_16 according to the present invention can be found in the following transcript(s): D11495_T6 and D11495_T11. Table 148 below describes the starting and ending position of this segment on each transcript.

Table 148 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 149.

Table 149 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): Dl 1495_P4.

Segment cluster D11495_node_22 according to the present invention can be found in the following transcript(s): D11495 T6, D11495_T11, D11495_T17 and D11495_T20. Table 150 below describes the starting and ending position of this segment on each transcript. Table 150 - Segment location on transcripts

Dl 1495 T20 268 290

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 151.

Table 151 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): D11495_P4.

Segment cluster D11495_node_24 according to the present invention can be found in the following transcript(s): D11495 T6 and D11495_T17. Table 152 below describes the starting and ending position of this segment on each transcript.

Table 152 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1495_P4.

DESCRIPTION FOR CLUSTER Dl 1793

Cluster Dl 1793 features 11 transcript(s) and 53 segment(s) of interest, the names for which are given in Tables 153 and 154, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 155.

Table 153 - Transcripts of interest

Transcript Name

Dl 1793 T5

Dl 1793 T6 Dl1793 TlO

Dl1793 T14

Dl1793 T18

Dl1793 T24

Dl1793 T32

Dl1793 T40

Dl1793 T41

Dl1793 T42

Dl1793 T43

Table154-Segmentsofinterest

Dl 1793 node 40

Dl 1793 node 41

Dl 1793 node 42

D11793 node 43

Dl 1793 node 44

Dl 1793 node 45

Dl 1793 node 46

Dl 1793 node 47

Dl 1793 node 48

Dl 1793 node 49

D11793 node 50

Dl 1793 node 51

Dl 1793 node 52

Dl 1793 node 53

Dl 1793 node 54

Dl 1793 node 55

Dl 1793 node 57

Dl 1793 node 58

Dl 1793 node 59

Dl 1793 node 60

Dl 1793 node 61

Dl 1793 node 62

Table 155 - Proteins of interest

These sequences are variants of the known protein Solute carrier family 2, facilitated glucose transporter, member 1 (SwissProt accession identifier GTR1_HUMAN; known also according to the synonyms Glucose transporter type 1, erythrocyte/brain; HepG2 glucose transporter), referred to herein as the previously known protein.

Protein Solute carrier family 2, facilitated glucose transporter, member 1 $ known or believed to have the following function(s): Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. The sequence for protein Solute carrier family 2, facilitated glucose transporter, member 1 is given at the end of the application, as "Solute carrier family 2, facilitated glucose transporter, member 1 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 156.

Table 156 -Amino acid mutations for Known Protein

Protein Solute carrier family 2, facilitated glucose transporter, member 1 localization is believed to be Integral membrane protein. Localizes primarily at the cell surface (By similarity).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: carbohydrate transport; glucose transport, which are annotation(s) related to Biological Process; transporter; sugar porter; glucose transporter, which are annotation(s) related to Molecular Function; and membrane fraction; membrane; integral membrane protein, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLinlc/>.

Cluster Dl 1793 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 9 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 9 and Table 157. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues, hepatocellular carcinoma, ovarian carcinoma and pancreas carcinoma.

Table 157 - Normal tissue distribution

Table 158 - P values and ratios for expression in cancerous tissue

As noted above, cluster Dl 1793 features 53 segment(s), which were listed in Table 154 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster D11793_node_0 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T40 and D11793_T42. Table 159 below describes the starting and ending position of this segment on each transcript.

Table 159 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793JP29, D11793_P6, D11793_P9, Dl 1793 JPI l, D11793_P26 and Dl 1793 P28.

Segment cluster D11793_node_2 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793 T14, D11793_T18, D11793_T40 and D11793_T42. Table 160 below describes the starting and ending position of this segment on each transcript

Table 160 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793JP9, D11793JP11 and D11793JP28. This segment can also be found in the following protein(s): D11793_P29, D11793_P6 and D11793_P26, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_4 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T41. Table 161 below describes the starting and ending position of this segment on each transcript.

Table 161 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 162.

Table 162 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): Dl 1793_P27.

Segment cluster D11793_node_5 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T41 and Dl 1793_T42. Table 163 below describes the starting and ending position of this segment on each transcript.

Table 163 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 164.

Table 164 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P27. This segment can also be found in the following protein(s): Dl 1793_P28, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_7 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T24 and D11793_T43. Table 165 below describes the starting and ending position of this segment on each transcript.

Table 165 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P13.

Segment cluster D11793_node_9 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T40 and D11793_T43. Table 166 below describes the starting and ending position of this segment on each transcript. Table 166 - Segment location on transcripts

This segment can be found in the following protein(s): Dl 1793 P26.

Segment cluster D11793_node_l l according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T32. Table 167 below describes the starting and ending position of this segment on each transcript.

Table 167 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P9.

Segment cluster D11793_node_13 according to the present invention is supported by 116 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14,

D11793_T18, D11793_T24 and D11793_T32. Table 168 below describes the starting and ending position of this segment on each transcript.

Table 168 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P9 and D11793JP11. This segment can also be found in the following protein(s): D11793_P29, D11793_P6 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_18 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 169 below describes the starting and ending position of this segment on each transcript.

Table 169 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P9 and D11793JP11. This segment can also be found in the following protein(s): D11793_P29, D11793_P6 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_19 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T14, D11793_T18 and D11793_T32. Table 170 below describes the starting and ending position of this segment on each transcript.

Table 170 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P9 and Dl 1793_P11.

Segment cluster D11793_node_37 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 171 below describes the starting and ending position of this segment on each transcript.

Table 171 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_63 according to the present invention is supported by 204 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 172 below describes the starting and ending position of this segment on each transcript.

Table 172 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793 JPl 1 and Dl 1793 JP13.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster D11793_node_l according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14,

D11793_T18, D11793_T40 and D11793_T42. Table 173 below describes the starting and ending position of this segment on each transcript.

Table 173 - Segment location on transcripts

Dl 1793 T42 135 161

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P29, D11793_P6, D11793_P9, D11793_P11, D11793_P26 and D11793_P28.

Segment cluster D11793_node_8 according to the present invention is supported by 118 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24, D11793_T40 and D11793_T43. Table 174 below describes the starting and ending position of this segment on each transcript.

Table 174 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P9 and D11793_P11. This segment can also be found in the following protein(s): D11793_P29, D11793_P6, D11793_P13 and D11793_P26, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_12 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14,

D11793_T18, D11793_T24 and D11793_T32. Table 175 below describes the starting and ending position of this segment on each transcript. Table 175 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D11793 P9 and D11793 P11. This segment can also be found in the following protein(s): D11793_P29, D11793_P6 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_14 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T32. Table 176 below describes the starting and ending position of this segment on each transcript.

Table 176 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P9.

Segment cluster D11793_node_15 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T32. Table 177 below describes the starting and ending position of this segment on each transcript. Table 177 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P9.

Segment cluster D11793_node_16 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14,

D11793_T18, D11793_T24 and D11793_T32. Table 178 below describes the starting and ending position of this segment on each transcript.

Table 178 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P9 and D11793_P11. This segment can also be found in the following protein(s): D11793_P29, D11793_P6 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_17 according to the present invention is supported by 130 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D1 1793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 179 below describes the starting and ending position of this segment on each transcript.

Table 179 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P9 and D11793_P11. This segment can also be found in the following protein(s): D11793_P29, D11793_P6 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_20 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 180 below describes the starting and ending position of this segment on each transcript.

Table 180 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P11. This segment can also be found in the following protein(s): Dl 1793_P29, D11793_P6, Dl 1793_P9 and Dl 1793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_21 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D1 1793_T32. Table 181 below describes the starting and ending position of this segment on each transcript. Table 181 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P11. This segment can also be found in the following protein(s): DI l 793_P29, D 11793_P6, D 11793_P9 and D 11793_P 13 , since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_22 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, Dl 1793_T24 and Dl 1793_T32. Table 182 below describes the starting and ending position of this segment on each transcript.

Table 182 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P11. This segment can also be found in the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9 and Dl 1793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_23 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, Dl 1793 _TlO, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 183 below describes the starting and ending position of this segment on each transcript.

Table 183 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P11. This segment can also be found in the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9 and Dl 1793JP13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_24 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T10 and D11793_T18. Table 184 below describes the starting and ending position of this segment on each transcript.

Table 184 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P11. This segment can also be found in the following protein(s): Dl 1793_P6, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_25 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 185 below describes the starting and ending position of this segment on each transcript. Table 185 - Segment location on transcripts

This segment can be found in the following protein(s): D11793_P29, D11793_P6, D11793_P9, D11793 Pl l and D11793 P13.

Segment cluster D11793_node_26 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 186 below describes the starting and ending position of this segment on each transcript.

Table 186 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793 P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_27 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 187 below describes the starting and ending position of this segment on each transcript.

Table 187 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793JP6. This segment can also be found in the following protein(s): D11793_P29, D11793JP9, Dl 1793 JPI l and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_28 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 188 below describes the starting and ending position of this segment on each transcript.

Table 188 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s):

D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript. Segment cluster D11793_node_31 according to the present invention is supported by 100 libraries. The number of libraπes was determined as previously described. This segment can be found in the following transcπpt(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 189 below describes the starting and ending position of this segment on each transcript.

Table 189 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793JP11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_34 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14,

D11793_T18, D11793_T24 and D11793_T32. Table 190 below describes the starting and ending position of this segment on each transcript.

Table 190 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is h the coding region for the corresponding transcript.

Segment cluster D11793_node_38 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14,

D11793_T18, D11793_T24 and D11793_T32. Table 191 below describes the starting and ending position of this segment on each transcript.

Table 191 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_40 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 192 below describes the starting and ending position of this segment on each transcript.

Table 192 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s):

D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_41 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 193 below describes the starting and ending position of this segment on each transcript.

Table 193 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_42 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcripts): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 194 below describes the starting and ending position of this segment on each transcript.

Table 194 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_43 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 195 below describes the starting and ending position of this segment on each transcript.

Table 195 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_44 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 196 below describes the starting and ending position of this segment on each transcript.

Table 196 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_45 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 197 below describes the starting and ending position of this segment on each transcript.

Table 197 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P6. This segment can also be found in the following protein(s): D11793_P29, D11793_P9, D11793_P11 and D11793_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D11793_node_46 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 198 below describes the starting and ending position of this segment on each transcript.

Table 198 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793 JP29, Dl 1793_P6, Dl 1793_P9, Dl 1793JP11 and Dl 1793_P13.

Segment cluster D11793_node_47 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 199 below describes the starting and ending position of this segment on each transcript. Table 199 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13.

Segment cluster D11793_node_48 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793JN4, D11793_T 18, D11793_T24 and D11793_T32. Table 200 below describes the starting and ending position of this segment on each transcript.

Table 200 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13.

Segment cluster D11793_node_49 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 201 below describes the starting and ending position of this segment on each transcript. Table 201 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13.

Segment cluster D11793_node_50 according to the present invention is supported by 158 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D1 1793_ T18, D11793_T24 and D11793_T32. Table 202 below describes the starting and ending position of this segment on each transcript.

Table 202 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13.

Segment cluster D11793_node_51 according to the present invention is supported by 182 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 203 below describes the starting and ending position of this segment on each transcript.

Table 203 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P29, D11793_P6, D11793_P9, D11793_P11 and D11793_P13. Segment cluster D11793_node_52 according to the present invention is supported by 190 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 204 below describes the starting and ending position of this segment on each transcript.

Table 204 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793JP6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13.

Segment cluster D11793_node_53 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793JN8, D11793_T24 and D11793_T32. Table 205 below describes the starting and ending position of this segment on each transcript.

Table 205 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13. Segment cluster D11793_node_54 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 206 below describes the starting and ending position of this segment on each transcript.

Table 206 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13.

Segment cluster D11793_node_55 according to the present invention is supported by 195 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14,

D11793JU8, D11793_T24 and D11793_T32. Table 207 below describes the starting and ending position of this segment on each transcript.

Table 207 - Segment location on transcripts

This segment can be found in a non-codmg region of transcript(s) that are related to the following protein(s): D11793_P29, D11793_P6, D11793_P9, D11793_P11 and D11793_P13.

Segment cluster D11793_node_57 according to the present invention is supported by 236 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, Dl 1793 _T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 208 below describes the starting and ending position of this segment on each transcript.

Table 208 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D 11793_P29, D 11793_P6, D 11793_P9, D 11793_P 11 and D 11793_P 13.

Segment cluster D11793_node_58 according to the present invention is supported by 229 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14,

D11793_T18, D11793_T24 and D11793_T32. Table 209 below describes the starting and ending position of this segment on each transcript.

Table 209 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13.

Segment cluster D11793_node_59 according to the present invention is supported by 218 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 210 below describes the starting and ending position of this segment on each transcript. Table 210 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793_P11 and Dl 1793_P13.

Segment cluster Dl 1793_node_60 according to the present invention is supported by 197 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 211 below describes the starting and ending position of this segment on each transcript. Table 211 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11793_P29, D11793_P6, D11793_P9, D11793_P11 and D11793_P13.

Segment cluster D11793jnode_61 according to the present invention is supported by 190 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 212 below describes the starting and ending position of this segment on each transcript.

Table 212 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793 JPl 1 and Dl 1793_P13.

Segment cluster D11793_node_62 according to the present invention can be found in the following transcript(s): D11793_T5, D11793_T6, D11793_T10, D11793_T14, D11793_T18, D11793_T24 and D11793_T32. Table 213 below describes the starting and ending position of this segment on each transcript.

Table 213 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1793_P29, Dl 1793_P6, Dl 1793_P9, Dl 1793 J^>11 and Dl 1793_P13. DESCRIPTION FOR CLUSTER D 12232

Cluster D 12232 features 7 transcript(s) and 48 segment(s) of interest, the names for which are given in Tables 214 and 215, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 216.

Table 214 - Transcripts of interest

Transcript Mame

D12232 TlO

D12232 T13

D12232 T15

D12232 T18

D12232 T21

D 12232 T22

D12232 T23

Table 215 - Segments of interest

Segment Nam€

D 12232 node 0

D12232 node 1

D12232 node 17

D 12232 node 25

D12232 node 27

D12232 node 30

D 12232 node 32

D12232 node 40

D12232 node 41

Table 216- Proteins of interest

These sequences are variants of the known protein Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl- tRNA synthetase (EC 6.1.1.17) (Glutamate-tRNA ligase); Prolyl- tRNA synthetase (EC 6.1.1.15) (Proline— tRNA ligase)] (SwissProt accession identifier SYEP_HUMAN), referred to herein as the previously known protein.

The sequence for protein Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl- tRNA synthetase (EC 6.1.1.17) (Glutamate-tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline— tRNA ligase)] is given at the end of the application, as "Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl- tRNA synthetase (EC 6.1.1.17) (Glutamate— tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline-tRNA ligase)] amino acid sequence".

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein complex assembly, which are annotation(s) related to Biological Process; and soluble fraction; cytoplasm, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster D 12232 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 10 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 10 and Table 217. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: adrenal cortical carcinoma, colorectal cancer, epithelial malignant tumors, a mixture of malignant tumors from different tissues and uterine malignancies.

Table 217 - Normal tissue distribution

Table 218 - P values and ratios for expression in cancerous tissue

As noted above, cluster D 12232 features 48 segment(s), which were listed in Table 215 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster D12232_node_0 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T13 and D12232_T18. Table 219 below describes the starting and ending position of this segment on each transcript.

Table 219 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12232_P9 and D12232JP14. Segment cluster D12232_node_l according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T13 and D12232_T18. Table 220 below describes the starting and ending position of this segment on each transcript.

Table 220 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P9 and D12232_P14.

Segment cluster D12232_node_17 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10. Table 221 below describes the starting and ending position of this segment on each transcript.

Table 221 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12232_P5.

Segment cluster D12232_node_25 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 222 below describes the starting and ending position of this segment on each transcript.

Table 222 - Segment location on transcripts

D12232 Tl 8 899 1025

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232_P14.

Segment cluster D12232_node_27 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 223 below describes the starting and ending position of this segment on each transcript.

Table 223 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232 P9 and D12232 P14.

Segment cluster D12232_node_30 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 224 below describes the starting and ending position of this segment on each transcript.

Table 224 - Segment location on transcripts

This segment can be found in the following protein(s): D12232JP5, D12232_P9 and D12232 P14. Segment cluster D12232_node_32 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 225 below describes the starting and ending position of this segment on each transcript.

Table 225 - Segment location on transcripts

This segment can be found in the following protein(s): D12232JP5, D12232_P9 and D12232_P14.

Segment cluster D12232_node_40 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T15. Table 226 below describes the starting and ending position of this segment on each transcript.

Table 226 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12232_P11.

Segment cluster D12232_node_41 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and

D12232_T18. Table 227 below describes the starting and ending position of this segment on each transcript.

Table 227 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9, D12232_P11 and D12232_P14.

Segment cluster D12232_node_43 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 228 below describes the starting and ending position of this segment on each transcript.

Table 228 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9, D12232 PI l and D12232 P14.

Segment cluster D12232_node_49 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 229 below describes the starting and ending position of this segment on each transcript. Table 229 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9, D12232_P11 and D12232_P14.

Segment cluster D12232_node_53 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 230 below describes the starting and ending position of this segment on each transcript. Table 230 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9, D12232 Pl l and D12232 P14.

Segment cluster D12232_node_55 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 231 below describes the starting and ending position of this segment on each transcript. Table 231 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9, D12232_P11 and D12232_P14.

Segment cluster D12232_node_60 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 232 below describes the starting and ending position of this segment on each transcript. Table 232 - Segment location on transcripts

This segment can be found in the following protein(s): D12232JP5, D12232JP9, D12232 PI l and D12232 P14.

Segment cluster D12232_node_63 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T18. Table 233 below describes the starting and ending position of this segment on each transcript.

Table 233 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P14. Segment cluster D12232_node_69 according to the present invention is supported by 97 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T15. Table 234 below describes the starting and ending position of this segment on each transcript.

Table 234 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232JP11.

Segment cluster D12232_node_73 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T15. Table 235 below describes the starting and ending position of this segment on each transcript.

Table 235 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232 PI l.

Segment cluster D12232_node_75 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T15. Table 236 below describes the starting and ending position of this segment on each transcript.

Table 236 - Segment location on transcripts

This segment can be found in the following protein(s): D12232JP5, D12232_P9 and D12232_P11.

Segment cluster D12232_node_77 according to the present invention is supported by 155 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T15. Table 237 below describes the starting and ending position of this segment on each transcript.

Table 237 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232 PI l.

Segment cluster D12232_node_80 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T13. Table 238 below describes the starting and ending position of this segment on each transcript.

Table 238 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P9. Segment cluster D12232_node_82 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T21, D12232_T22 and D12232_T23. Table 239 below describes the starting and ending position of this segment on each transcript.

Table 239 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster D12232_node_85 according to the present invention is supported by 181 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T15, D12232_T21, D12232_T22 and D12232_T23. Table 240 below describes the starting and ending position of this segment on each transcript.

Table 240 - Segment location on transcripts

This segment can be found in the following protein(s): D12232JP5 and D12232_P11.

Segment cluster D12232_node__87 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T22. Table 241 below describes the starting and ending position of this segment on each transcript. Table 241 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster D12232_node_6 according to the present invention can be found in the following transcript(s): D12232_T13 and D12232_T18. Table 242 below describes the starting and ending position of this segment on each transcript.

Table 242 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P9 and D12232_P14.

Segment cluster D12232_node_7 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T13 and D12232_T18. Table 243 below describes the starting and ending position of this segment on each transcript.

Table 243 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P9 and D12232_P14.

Segment cluster D12232_node_12 according to the present invention is supported by 89 libraries. The number of libraries was determined as previous Iy described. This segment can be found in the following transcript(s): D12232_T13 and D12232_T18. Table 244 below describes the starting and ending position of this segment on each transcript.

Table 244 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P9 and D12232_P14.

Segment cluster D12232_node_14 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T13 and D12232_T18. Table 245 below describes the starting and ending position of this segment on each transcript.

Table 245 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P9 and D12232_P14.

Segment cluster D12232_node_15 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T13 and D12232_T18. Table 246 below describes the starting and ending position of this segment on each transcript.

Table 246 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P9 and D12232JP14.

Segment cluster D12232_node_18 according to the present invention can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 247 below describes the starting and ending position of this segment on each transcript.

Table 247 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12232JP5. This segment can also be found in the following protein(s): D12232_P9 and D12232_P14, since it is in the coding region for the corresponding transcript.

Segment cluster D12232_node_19 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the βllowing transcriρt(s): D12232_T10, D12232_T13 and D 12232 JN 8. Table 248 below describes the starting and ending position of this segment on each transcript.

Table 248 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12232_P5. This segment can also be found in the following protein(s): D12232_P9 and D12232_P14, since it is in the coding region for the corresponding transcript.

Segment cluster D12232_node_20 according to the present invention can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 249 below describes the starting and ending position of this segment on each transcript.

Table 249 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12232_P5. This segment can also be found in the following protein(s): D12232_P9 and D12232_P14, since it is in the coding region for the corresponding transcript.

Segment cluster D12232_node_22 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 250 below describes the starting and ending position of this segment on each transcript.

Table 250 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232 P14. Segment cluster D12232_node_34 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 251 below describes the starting and ending position of this segment on each transcript.

Table 251 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232_P14.

Segment cluster D12232_node_36 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 252 below describes the starting and ending position of this segment on each transcript.

Table 252 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232 P14.

Segment cluster D12232_node_38 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T18. Table 253 below describes the starting and ending position of this segment on each transcript. Table 253 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232 P14.

Segment cluster D12232_node_45 according to the present invention is supported by 52 libraries. The number of libraries ^■was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 254 below describes the starting and ending position of this segment on each transcript.

Table 254 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9, D12232_P11 and D12232_P14.

Segment cluster D12232_node_47 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 255 below describes the starting and ending position of this segment on each transcript.

Table 255 - Segment location on transcripts

This segment can be found in the following protein(s): D12232JP5, D12232_P9, D12232_P11 and D12232_P14.

Segment cluster D12232_node_51 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 256 below describes the starting and ending position of this segment on each transcript.

Table 256 - Segment location on transcripts

This segment can be found in the following protein(s): D12232JP5, D12232_P9, D12232 PI l and D12232 P14.

Segment cluster D12232_node_58 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 257 below describes the starting and ending position of this segment on each transcript. Table 257 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9, D12232 Pl l and D12232 P14.

Segment cluster D12232_node_62 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13, D12232_T15 and D12232_T18. Table 258 below describes the starting and ending position of this segment on each transcript.

Table 258 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9, D12232_P11 and D12232_P14.

Segment cluster D12232_node_65 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T15. Table 259 below describes the starting and ending position of this segment on each transcript.

Table 259 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232JP11.

Segment cluster D12232_node_67 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T15. Table 260 below describes the starting and ending position of this segment on each transcript.

Table 260 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232 PI l.

Segment cluster D12232_node_71 according to the present invention can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232JN5. Table 261 below describes the starting and ending position of this segment on each transcript.

Table 261 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232 PI l. Segment cluster D12232_node_72 according to the present invention can be found in the following transcript(s): D12232_T10, D12232JN3 and D12232_T15. Table 262 below describes the starting and ending position of this segment on each transcript. Table 262 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232JP11.

Segment cluster D12232_node_79 according to the present invention is supported by 158 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T13 and D12232_T15. Table 263 below describes the starting and ending position of this segment on each transcript.

Table 263 - Segment location on transcripts

This segment can be found in the following protein(s): D12232_P5, D12232_P9 and D12232 PIl.

Segment cluster D12232_node_83 according to the present invention is supported by 168 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T10, D12232_T15, D12232_T21, D12232_T22 and D12232_T23. Table 264 below describes the starting and ending position of this segment on each transcript. Table 264 - Segment location on transcripts

This segment can be found in the following protein(s): D12232JP5 and D12232JP11.

Segment cluster D12232_node_84 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12232_T23. Table 265 below describes the starting and ending position of this segment on each transcript.

Table 265 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster D12232_node_86 according to the present invention can be found in the following transcript(s): D12232_T22. Table 266 below describes the starting and ending position of this segment on each transcript.

Table 266 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER FOO 120 Cluster FOO 120 features 1 transcript(s) and 73 segment(s) of interest, the names for which are given in Tables 267 and 268, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 269.

Table 267 - Transcripts of interest

TranscriptName

F00120 T15

Table268-Segmentsofinterest

SegmentName

F00120 node 4

FOO120 node 45

FOO120 node 0

FOO120 node 1

FOO120 node 2

F00120 node 3

F00120 node 5

F00120 node 6

FOO120 node 7

F00120 node 8

FOO120 node 9

F00120 node 11

F00120 node 12

FOO120 node 13

F00120 node 14

FOO120 node 15

FOO120 node 16

F00120 node 17

FOO120 node 20

FOO120 node 23

F00120 node 24

F00120_.node _26

F00120 node 27

F00120 node 28

FOO120 node 29

F00120 node 32

F00120 node 33

F00120 node 36

F00120 node 37

F00120 node 38

F00120 node 39 FOO120 node 44

FOO120 node 46

FOO120 node 48

F00120 node 49

F00120 node 51

FOO120 node 52

FOO120 node 53

F00120 node 54

F00120 node 55

FOO120 node _56

F00120 node 57

F00120 node 58

FOO120 node 59

F00120 node 60

F00120 node 61

FOO120 node 62

FOO120 node 63

FOO120 node 64

FOO120 node 65

F00120 node 66

FOO120 node 67

FOO120 node 68

F00120 node 69

F00120 node 70

F00120 node 71

FOO120 node 72

F00120 node 73

F00120 node 74

F00120 node 75

F00120 node 76

F00120 node 77

F00120 node 78

F00120 node 79

FOO120 node 80

F00120 node 81

F00120 node 82

FOO120 node 83

F00120 node 84

F00120 node 86

FOO120 node 87

F00120_ node 88

FOO120 node 89

Table 269 - Proteins of interest

These sequences are variants of the known protein Desmin (SwissProt accession identifier DESM_HUMAN), referred to herein as the previously known protein.

Protein Desmin is known or believed to have the following function(s): Desmin are class- III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z- line structures. The sequence for protein Desmin is given at the end of the application, as "Desmin amino acid sequence". Known polymorphisms for this sequence are as shown in Table 270. Table 270 - Amino acid mutations for Known Protein

Protein Desmin localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: muscle contraction; cytoskeleton organization and biogenesis; control of heart, which are annotation(s) related to Biological Process; structural protein of cytoskeleton, which are annotation(s) related to Molecular Function; and intermediate filament, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster F00120. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 11 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 11, concerning the number of heart-specific clones in libraries/sequences; as well as with regard to the histogram in Figures , 12 - 13, concerning the actual expression of oligonucleotides in various tissues, including heart.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 5.2; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 1.5; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 3.20E-73.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 5.2, which clearly supports specific expression in heart tissue. As noted above, cluster FOO 120 features 73 segment(s), which were listed in Table 268 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster F00120_node_4 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 271 below describes the starting and ending position of this segment on each transcript.

Table 271 - Segment location on transcripts

This segment can be found in the following protein(s): F00120JP9.

Segment cluster F00120_node_45 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 272 below describes the starting and ending position of this segment on each transcript.

Table 272 - Segment location on transcripts

This segment can be found in the following protein(s): F00120JP9. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster F00120_node_0 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 273 below describes the starting and ending position of this segment on each transcript.

Table 273 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_l according to the present invention can be found in the following transcript(s): F00120_T15. Table 274 below describes the starting and ending position of this segment on each transcript.

Table 274 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): FOO 120_P9.

Segment cluster F00120_node_2 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 275 below describes the starting and ending position of this segment on each transcript.

Table 275 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_3 according to the present invention can be found in the following transcript(s): F00120_T15. Table 276 below describes the starting and ending position of this segment on each transcript.

Table 276 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_5 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 277 below describes the starting and ending position of this segment on each transcript.

Table 277 - Segment location on transcripts

This segment can be found in the following protein(s): F00120JP9.

Segment cluster F00120_node_6 according to the present invention can be found in the following transcript(s): F00120_T15. Table 278 below describes the starting and ending position of this segment on each transcript.

Table 278 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_7 according to the present invention can be found in the following transcript(s): F00120_T15. Table 279 below describes the starting and ending position of this segment on each transcript.

Table 279 - Segment location on transcripts

This segment can be found in the following protein(s): F00120JP9.

Segment cluster F00120_node_8 according to the present invention is supported by 113 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 280 below describes the starting and ending position of this segment on each transcript.

Table 280 - Segment location on transcripts

This segment can be found in the following protein(s): F00120JP9.

Segment cluster F00120_node_9 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following trarficript(s): F00120_T15. Table 281 below describes the starting and ending position of this segment on each transcript.

Table 281 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_l l according to the present invention is supported by 127 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 282 below describes the starting and ending position of this segment on each transcript.

Table 282 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_12 according to the present invention can be found in the following transcript(s): F00120_T15. Table 283 below describes the starting and ending position of this segment on each transcript. Table 283 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_13 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 284 below describes the starting and ending position of this segment on each transcript.

Table 284 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_ 14 according to the present invention can be found in the following transcript(s): F00120_T15. Table 285 below describes the starting and ending position of this segment on each transcript.

Table 285 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_15 according to the present invention can be found in the following transcript(s): F00120_T15. Table 286 below describes the starting and ending position of this segment on each transcript.

Table 286 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_16 according to the present invention can be found in the following transcript(s): F00120_T15. Table 287 below describes the starting and ending position of this segment on each transcript.

Table 287 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_17 according to the present invention is supported by 178 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 288 below describes the starting and ending position of this segment on each transcript.

Table 288 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_20 according to the present invention is supported by 190 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 289 below describes the starting and ending position of this segment on each transcript.

Table 289 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_23 according to the present invention can be found in the following transcript(s): F00120_T15. Table 290 below describes the starting and ending position of this segment on each transcript.

Table 290 - Segment location on transcripts

F00120 T15 790 811

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_24 according to the present invention is supported by 221 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 291 below describes the starting and ending position of this segment on each transcript.

Table 291 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_26 according to the present invention is supported by 236 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 292 below describes the starting and ending position of this segment on each transcript.

Table 292 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_27 according to the present invention B supported by 241 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 293 below describes the starting and ending position of this segment on each transcript.

Table 293 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_28 according to the present invention is supported by 254 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 294 below describes the starting and ending position of this segment on each transcript.

Table 294 - Segment location on transcripts

This segment can be found in the following protein(s): F00120 P9.

Segment cluster F00120_node_29 according to the present invention can be found in the following transcript(s): F00120_T15. Table 295 below describes the starting and ending position of this segment on each transcript. Table 295 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_32 according to the present invention is supported by 269 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 296 below describes the starting and ending position of this segment on each transcript.

Table 296 - Segtnent location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_33 according to the present invention is supported by 288 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 297 below describes the starting and ending position of this segment on each transcript.

Table 297 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_36 according to the present invention is supported by 330 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 298 below describes the starting and ending position of this segment on each transcript.

Table 298 - Segment location on transcripts

This segment can be found in the following protein(s): F00120JP9.

Segment cluster F00120_node_37 according to the present invention is supported by 309 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 299 below describes the starting and ending position of this segment on each transcript.

Table 299 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_38 according to the present invention is supported by 324 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 300 below describes the starting and ending position of this segment on each transcript.

Table 300 - Segment location on transcripts

This segment can be found in the following protein(s): F00120 P9.

Segment cluster F00120_node_39 according to the present invention can be found in the following transcript(s): F00120 T15. Table 301 below describes the starting and ending position of this segment on each transcript. Table 301 - Segment location on transcripts

This segment can be found in the following protein(s): F00120_P9.

Segment cluster F00120_node_44 according to the present invention is supported by 316 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 302 below describes the starting and ending position of this segment on each transcript.

Table 302 - Segment location on transcripts

This segment can be found in the following protein(s): F00120JP9.

Segment cluster F00120_node_46 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 303 below describes the starting and ending position of this segment on each transcript.

Table 303 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_48 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 304 below describes the starting and ending position of this segment on each transcript.

Table 304 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_49 according to the present invention is supported by 344 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 305 below describes the starting and ending position of this segment on each transcript.

Table 305 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_51 according to the present invention is supported by 331 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 306 below describes the starting and ending position of this segment on each transcript.

Table 306 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_52 according to the present invention can be found in the following transcript(s): F00120_T15. Table 307 below describes the starting and ending position of this segment on each transcript. Table 307 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120_P9. Segment cluster F00120_node_53 according to the present invention can be found in the following transcπpt(s): F00120_T15. Table 308 below describes the starting and ending position of this segment on each transcript.

Table 308 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_54 according to the present invention can be found in the following transcript(s): F00120_T15. Table 309 below describes the starting and ending position of this segment on each transcript.

Table 309 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_55 according to the present invention can be found in the following transcript(s): F00120_T15. Table 310 below describes the starting and ending position of this segment on each transcript. Table 310 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9. Segment cluster F00120_node_56 according to the present invention can be found in the following transcript(s): F00120_T15. Table 311 below describes the starting and ending position of this segment on each transcript.

Table 311 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_57 according to the present invention can be found in the following transcript(s): F00120_T15. Table 312 below describes the starting and ending position of this segment on each transcript.

Table 312 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_58 according to the present invention can be found in the following transcript(s): F00120_T15. Table 313 below describes the starting and ending position of this segment on each transcript. Table 313 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120_P9. Segment cluster F00120_node_59 according to the present invention can be found in the following transcript(s): F00120_T15. Table 314 below describes the starting and ending position of this segment on each transcript.

Table 314 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_60 according to the present invention can be found in the following transcript(s): F00120_T15. Table 315 below describes the starting and ending position of this segment on each transcript.

Table 315 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_61 according to the present invention is supported by 332 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 316 below describes the starting and ending position of this segment on each transcript.

Table 316 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9. Segment cluster F00120_node_62 according to the present invention can be found in the following transcript(s): F00120_T15. Table 317 below describes the starting and ending position of this segment on each transcript. Table 317 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_63 according to the present invention can be found in the following transcript(s): F00120_T15. Table 318 below describes the starting and ending position of this segment on each transcript.

Table 318 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120JP9.

Segment cluster F00120_node_64 according to the present invention can be found in the following transcript(s): F00120_T15. Table 319 below describes the starting and ending position of this segment on each transcript.

Table 319 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120JP9. Segment cluster F00120_node_65 according to the present invention can be found in the following transcript(s): F00120_T15. Table 320 below describes the starting and ending position of this segment on each transcript. Table 320 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_66 according to the present invention is supported by 323 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 321 below describes the starting and ending position of this segment on each transcript.

Table 321 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120__node_67 according to the present invention can be found in the following transcript(s): F00120_T15. Table 322 below describes the starting and ending position of this segment on each transcript.

Table 322 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_68 according to the present invention is supported by 311 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 323 below describes the starting and ending position of this segment on each transcript.

Table 323 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120JP9.

Segment cluster F00120_node_69 according to the present invention can be found in the following transcript(s): F00120_T15. Table 324 below describes the starting and ending position of this segment on ^'each transcript.

Table 324 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_70 according to the present invention can be found in the following transcript(s): F00120_T15. Table 325 below describes the starting and ending position of this segment on each transcript.

Table 325 - Segment location on transcripts

I F00120 T15 1 3677 | 3699 |

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_71 according to the present invention can be found in the following transcript(s): F00120_T15. Table 326 below describes the starting and ending position of this segment on each transcript.

Table 326 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_72 according to the present invention can be found in the following transcript(s): F00120_T15. Table 327 below describes the starting and ending position of this segment on each transcript.

Table 327 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_73 according to the present invention is supported by 333 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 328 below describes the starting and ending position of this segment on each transcript. Table 328 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_74 according to the present invention is supported by 324 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 329 below describes the starting and ending position of this segment on each transcript.

Table 329 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120 P9.

Segment cluster F00120_node_75 according to the present invention is supported by 321 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 330 below describes the starting and ending position of this segment on each transcript.

Table 330 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_76 according to the present invention is supported by 327 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 331 below describes the starting and ending position of this segment on each transcript.

Table 331 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_77 according to the present invention can be found in the following transcript(s): F00120_T15. Table 332 below describes the starting and ending position of this segment on each transcript.

Table 332 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_78 according to the present invention can be found in the following transcript(s): F00120_T15. Table 333 below describes the starting and ending position of this segment on each transcript.

Table 333 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9. Segment cluster F00120_node_79 according to the present invention can be found in the following transcript(s): F00120_T15. Table 334 below describes the starting and ending position of this segment on each transcript.

Table 334 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_80 according to the present invention is supported by 292 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 335 below describes the starting and ending position of this segment on each transcript.

Table 335 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_81 according to the present invention can be found in the following transcript(s): F00120_T15. Table 336 below describes the starting and ending position of this segment on each transcript.

Table 336 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120_P9. Segment cluster F00120_node_82 according to the present invention can be found in the following transcript(s): F00120_T15. Table 337 below describes the starting and ending position of this segment on each transcript. Table 337 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_83 according to the present invention can be found in the following transcript(s): F00120_T15. Table 338 below describes the starting and ending position of this segment on each transcript.

Table 338 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120 P9.

Segment cluster F00120_node_84 according to the present invention can be found in the following transcript(s): F00120_T15. Table 339 below describes the starting and ending position of this segment on each transcript.

Table 339 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9. Segment cluster F00120_node_86 according to the present invention can be found in the following transcript(s): F00120_T15. Table 340 below describes the starting and ending position of this segment on each transcript.

Table 340 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_87 according to the present invention can be found in the following transcript(s): F00120_T15. Table 341 below describes the starting and ending position of this segment on each transcript.

Table 341 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F00120JP9.

Segment cluster F00120_node_88 according to the present invention can be found in the following transcript(s): F00120_T15. Table 342 below describes the starting and ending position of this segment on each transcript.

Table 342 - Segment location on transcripts

I F00120 T15 I I 4095 I I 4116 I

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

Segment cluster F00120_node_89 according to the present invention is supported by 192 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F00120_T15. Table 343 below describes the starting and ending position of this segment on each transcript.

Table 343 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F00120_P9.

DESCRIPTION FOR CLUSTER F 10611

Cluster F 10611 features 30 transcript(s) and 76 segment(s) of interest, the names for which are given in Tables 344 and 345, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 346.

Table 344 - Transcripts of interest

Transcript Name

F10611 TO

F10611 Tl

F10611 T2

F10611 T3

F10611 T4

F10611 T5

F10611 T6

F10611 T7

F10611 T8

F10611 T9

F10611 TlO

F10611 TIl F10611 T12

F10611 T13

F10611 T14

F10611 T15

F10611 T16

F10611 T17

F10611 T19

F10611 T20

F10611 T21

F10611_. _T22

F10611 T23

F10611 T24

F10611 T25

F10611 T26

F10611 T27

F10611 T28

F10611 T31

F10611 T32

Table345-Segmentsofinterest

SegmentName

F10611 node 4

F10611 node 6

F10611 node 11

F10611 node 16

F10611 node 18

F10611 node 19

F10611 node 22

F10611 node 25

F10611 node 26

F10611 node 29

F10611 node 30

F10611_. node .31

F10611 node 34

F10611 node 38

F10611 node 44

F10611 node 46

F10611 node 56

F10611 node 59

F10611 node 63

F10611 node 66

F10611 node 68

F10611 node 70 F10611 node 91

F1061 1 node 98

F10611 node 100

F10611 node 107

F1061 1 node 109

F1061 1 node 113

F1061 1 node 114

F1061 1 node 116

F1061 1 node 117

F1061 1 node 121

Table 346 - Proteins of interest

Cluster F 10611 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 14 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 14 and Table 347. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 347 - Normal tissue distribution

Table 348 - P values and ratios for expression in cancerous tissue

As noted above, cluster F 10611 features 76 segment(s), which were listed in Table 345 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster F10611_node_4 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20, F10611_T24 and F10611_T27. Table 349 below describes the starting and ending position of this segment on each transcript.

Table 349 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P10 and F10611_P24. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P3, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P8, F10611JP9, F10611JP11, F10611_P12, F10611_P13, F10611JP14, F10611_P15, F10611_P16, F10611_P17, F10611_P18, F10611_P19 and F 10611_P21, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_6 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F10611_Tl l, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20, F10611_T24 and F10611_T27. Table 350 below describes the starting and ending position of this segment on each transcript.

Table 350 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P10 and F10611_P24. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611JP3, F10611JP4, F10611_P5, F10611_P6, F10611_P7, F10611_P8, F10611_P9, F10611JP11, F10611JP12, F10611JP13, F10611JP14, F10611JP15, F10611JP16, F10611_P17, F10611JP18, F10611_P19 and F10611_P21, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_l l according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F1061 1_T17, F10611 T19 and F1061 l_T20. Table 351 below describes the starting and ending position of this segment on each transcript.

Table 351 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P10. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P3, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P8, F10611_P9, F10611JP11, F10611_P12, F10611JP13, F10611_P14, F10611_P15, F10611_P16, F10611_P17, F10611_P18 and F10611JP19, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_16 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611JTO, F1O611_T1, F10611JT2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F1061 1_T16, F 10611_T17, F 10611_T19 and F 1061 l_T20. Table 352 below describes the starting and ending position of this segment on each transcript.

Table 352 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P10 and F10611_P12. This segment can also be found in the following protein(s): F10611_P29, F10611JP2, F10611_P3, F10611_P4, F10611_P5, F10611JP6, F10611_P7, F10611_P8, F10611_P9, F10611JP11, F10611JP13, F10611_P14, F10611_P15, F10611JP16, F10611JP17, F10611JP18 and F10611_P19, since it is in the coding region for the corresponding transcript. Segment cluster F10611_node_18 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, FIOoI l-TS₅ F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19 and F10611_T20. Table 353 below describes the starting and ending position of this segment on each transcript.

Table 353 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P10 and F10611JP12. This segment can also be found in the following protein(s): F10611_P29, F10611JP2, F10611_P3, F10611_P4, F10611_P5, F10611JP6, F10611JP7, F10611_P8, F10611JP9, F10611JP11, F10611_P13, F10611JP14, F10611JP15, F10611JP16, F10611_P17, F10611_P18 and F10611 P19, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_19 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T10. Table 354 below describes the starting and ending position of this segment on each transcript.

Table 354 - Segment location on transcripts

This segment can be found in the following protein(s): F10611_P11.

Segment cluster F10611_node_22 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T22 and F10611_T23. Table 355 below describes the starting and ending position of this segment on each transcript.

Table 355 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F1061 l_P10 and F1061 l_P20.

Segment cluster F10611_node_25 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T21 and F10611_T31. Table 356 below describes the starting and ending position of this segment on each transcript.

Table 356 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F1061 l_P20 and F10611_P27.

Segment cluster F10611_node_26 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611 T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20, F10611_T21, F10611_T22, F10611_T23 and F10611_T31. Table 357 below describes the starting and ending position of this segment on each transcript.

Table 357 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P9, F1O611_P11, F10611JP12, F10611JP20, F10611_P10 and F10611_P27. This segment can also be found in the following protein(s): F10611_P29, F10611JP2, F10611_P3, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P8, F10611_P13, F10611_P14, F10611JP15, F10611_P16, F10611_P17, F10611_P18 and F 1061 I P 19, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_29 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T2, F10611_T8, F10611_T10, F1O611_T11, F10611_T19, F10611_T21 and F10611_T23. Table 358 below describes the starting and ending position of this segment on each transcript. Table 358 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P9, F10611JP11 and F10611_P12. This segment can also be found in the following protein(s): F10611_P3 and F10611_P20, since it is in the coding region for the corresponding transcript. Segment cluster F1061 1_node_30 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20, F10611_T21, F10611_T22, F10611_T23 and F10611_T31. Table 359 below describes the starting and ending position of this segment on each transcript.

Table 359 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 360.

Table 360 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611JP5, F10611_P6, F10611_P7, F10611_P8, F10611_P10, F10611_P13, F10611JP14, F10611JP15, F10611_P16, F10611_P17, F10611JP18, F10611_P19 and F 10611_P27, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_31 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T2, F10611_T8, F1061 I_TlO, F1O611_T11, F 10611_T21 , F 10611_T23 and F 10611_T31. Table 361 below describes the starting and ending position of this segment on each transcript.

Table 361 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P27, since it is in the coding region for the corresponding transcript.

Segment cluster F10611__node_34 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T19, F10611_T20 and F10611_T31. Table 362 below describes the starting and ending position of this segment on each transcript.

Table 362 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611 P3 and F10611_P27. This segment can also be found in the following protein(s): F10611_P19, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_38 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 363 below describes the starting and ending position of this segment on each transcript.

Table 363 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 364.

Table 364 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611JP2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P10, F10611_P13, F10611_P14, F10611JP15, F10611_P16, F10611_P17 and F10611_P18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_44 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F1061 1_T8, F10611_T9, F10611_T10, F10611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T 16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 365 below describes the starting and ending position of this segment on each transcript.

Table 365 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611JP5, F10611_P6, F10611JP7, F10611_P10, F10611JP13, F10611_P14, F10611_P15, F10611_P16, F10611_P17 and F10611JP18, since it is in the coding region for the corresponding transcript. Segment cluster F10611_node_46 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F1O61 1_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 366 below describes the starting and ending position of this segment on each transcript.

Table 366 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611JP12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F1061 IJPlO, F10611JP13, F10611JP14, F10611JP15, F10611JP16, F10611_P17 and F10611JP18, since it is in the coding region for the corresponding transcript. Segment cluster F10611_node_56 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611 T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 367 below describes the starting and ending position of this segment on each transcript.

Table 367 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 368. Table 368 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611JP6, F10611_P7, F10611JP10, F10611JP13, F10611_P14, F10611_P15, F10611_P16, F10611_P17 and F10611JP18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_59 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 369 below describes the starting and ending position of this segment on each transcript.

Table 369 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611J^>4, F10611_P5, F10611JP6, F10611_P7, F1061 IJPlO, F10611_P13, F10611_P14, F10611_P16, F10611 P17 and F10611_P18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_63 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611 T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 370 below describes the starting and ending position of this segment on each transcript.

Table 370 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611JP5, F10611_P6, F10611_P7, F10611_P10, F10611_P13, F10611_P14, F10611_P16, F10611_P17 and F10611 P18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_66 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T21, F10611_T22 and F10611_T23. Table 371 below describes the starting and ending position of this segment on each transcript.

Table 371 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F1061 IJPlO, F10611_P13, F10611_P14, F10611_P16 and F1061 IJP 17, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_68 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3,

F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F1061 I_TlO, F10611_T11,

F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T21, F10611_T22 and

F10611_T23. Table 372 below describes the starting and ending position of this segment on each transcript.

Table 372 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611JP9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611 P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F1061 IJPlO, F10611JP13, F10611JP14, F 10611_P16 and F 10611_P17, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_70 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T25. Table 373 below describes the starting and ending position of this segment on each transcript.

Table 373 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P22.

Segment cluster F10611_node_73 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following rranscript(s): F10611_T0, F10611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F10611_Tl l, F1061 1_T12, F10611_T13, F10611_T15, F10611_T16, F1061 1_T21, F1061 1_T22, F10611_T23 and F10611_T25. Table 374 below describes the starting and ending position of this segment on each transcript.

Table 374 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611JP3, F10611_P9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611JP6, F10611_P7, F1061 IJPlO, F10611_P13, F10611JP14, F10611_P16, F10611_P17 and F10611_P22, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_81 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F1061 1_T6, F1061 1_T8, F10611_T9, F1061 I_TlO, F10611_T1 1, F10611_T12, F10611_T13, F1061 1_T15, F10611_T16, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F1061 1_T25 and F10611_T26. Table 375 below describes the starting and ending position of this segment on each transcript.

Table 375 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcripts) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611JP3, F10611JP9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611JP6, F10611_P7, F10611_P10, F10611JP13, F10611JP14, F10611_P16, F10611_P17, F10611JP21, F10611_P22 and F10611_P23, since it is in the coding region for the corresponding transcript. Segment cluster F10611_node_83 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611 T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611 T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T21, F1061 1_T22, F10611_T23, F10611_T24, F10611_T25 and F10611_T26. Table 376 below describes the starting and ending position of this segment on each transcript.

Table 376 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611JP29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F1061 IJPlO, F10611_P13, F10611_P14, F10611__P16, F10611_P17, F10611JP21, F10611_P22 and F10611_P23, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_85 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3,

F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11,

F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T21, F10611_T22,

F10611_T23, F10611_T24, F10611_T25 and F10611_T26. Table 377 below describes the starting and ending position of this segment on each transcript.

Table 377 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611 P12^' and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P10, F10611 P13, F10611_P14, F10611_P16, F10611_P17, F10611_P21, F10611_P22 and F10611_P23, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_93 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611 T28 and F10611_T32. Table 378 below describes the starting and ending position of this segment on each transcript.

Table 378 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611JP25.

Segment cluster F10611_node_94 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T28 and F10611_T32. Table 379 below describes the starting and ending position of this segment on each transcript.

Table 379 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 380.

Table 380 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611JP20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P10, F10611JP13, F10611JP14, F10611JP16, F10611JP21, F10611JP22, F10611_P23 and F10611_P25, since it is in the coding region for the corresponding transcript. Segment cluster F1061 1_node_95 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T15 and F10611_T32. Table 381 below describes the starting and ending position of this segment on each transcript.

Table 381 - Segment location on transcripts

This segment can be found in the following protein(s): F10611_P16.

Segment cluster F10611_node_99 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T4. Table 382 below describes the starting and ending position of this segment on each transcript.

Table 382 - Segment location on transcripts

This segment can be found in the following protein(s): F10611_P5.

Segment cluster F10611_node_102 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26 and F10611_T28. Table 383 below describes the starting and ending position of this segment on each transcript.

Table 383 - Segment location on transcripts

, This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611_P9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P7, F1061 IJPlO, F10611JP13, F10611JP14, F10611_P21, F10611JP22, F10611JP23 and F10611JP25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_104 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T27. Table 384 below describes the starting and ending position of this segment on each transcript.

Table 384 - Segment location on transcripts

F10611 T27 458 734

This segment can be found in a non-codmg region of transcript(s) that are related to the following protein(s): F10611_P24.

Segment cluster F10611_node_105 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F10611_T11, F10611_T12, F10611_T13, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 385 below describes the starting and ending position of this segment on each transcript.

Table 385 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611JP9, F1O611_P11, F10611JP12, F10611JP20 and F10611_P24. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P6, F10611_P7, F1061 IJPlO, F10611_P13, F10611_P14, F10611_P21, F10611_P22, F10611_P23 and F10611_P25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_l ll according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611_T1, F10611_T2, F10611_T3,

F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F1061 I_TlO, F1O611_T11,

F10611_T12, F10611_T13, F10611_T21, F10611_T22, F10611_T23, F10611_T24,

F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 386 below describes the starting and ending position of this segment on each transcript.

Table 386 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611_P6, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611JP4, F10611_P7, F1061 IJPlO, F10611_P13, F10611_P14, F10611JP21, F10611_P22, F10611JP23, F10611_P24 and F10611_P25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611 node_l 19 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_TO, F10611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F10611_T11, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 387 below describes the starting and ending position of this segment on each transcript.

Table 387 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611_P6, F10611_P9, F1061 IJPl 1, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P7, F10611_P10, F10611_P21, F10611_P22, F10611_P23, F10611_P24 and F10611_P25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_122 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 388 below describes the starting and ending position of this segment on each transcript.

Table 388 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611_P6, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611JP7, F10611_P10, F10611_P21, F10611_P22, F10611_P23, F10611_P24 and F10611_P25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_125 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 389 below describes the starting and ending position of this segment on each transcript.

Table 389 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P2, F10611JP3, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P9, F10611JP10, F1O611_P11, F10611_P12, F10611_P20, F10611_P21, F10611_P22, F10611_P23, F10611_P24 and F10611_P25. This segment can also be found in the following protein(s): F10611_P29, since it is in the coding region for the corresponding transcript.

Segment cluster F1061 l_node_126 according to the present invention is supported by 141 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 390 below describes the starting and ending position of this segment on each transcript.

Table 390 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P29, F10611_P2, F10611_P3, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P9, F10611_P10, F1O611_P11, F10611_P12, F10611_P20, F10611_P21, F10611_P22, F10611_P23, F10611 P24 and F10611_P25. This segment can also be found in the following protein(s): F10611_P8, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_127 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T14, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 391 below describes the starting and ending position of this segment on each transcript.

Table 391 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P29, F10611_P2, F10611_P3, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P8, F10611_P9, F10611_P10, F10611JP11, F10611_P12, F10611_P20, F10611_P21, F10611_P22, F10611_P23, F10611_P24 and F10611_P25. This segment can also be found in the following protein(s): F10611_P15, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster F10611_node_0 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F10611_Tl l, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20, F1061 1_T24 and F1061 1_T27. Table 392 below describes the starting and ending position of this segment on each transcript.

Table 392 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611JP29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611JP10, F10611_P12, F10611JP13, F10611JP14, F10611JP16, F10611_P17, F10611JP18, F10611JP21 and F10611_P24. This segment can also be found in the following protein(s): F10611_P3, F10611_P8, F10611_P9, F1O611_P11, F10611_P15 and F10611_P19, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_2 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F1061 1_T2, F1061 1_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19, F1061 1_T20, F10611_T24 and F10611_T27. Table 393 below describes the starting and ending position of this segment on each transcript.

Table 393 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P10 and F10611_P24. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611JP3, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P8, F10611_P9, F1O611_P11, F10611_P12, F10611JP13, F10611JP14, F10611JP15, F10611_P16, F10611_P17, F10611JP18, F10611_P19 and F10611_P21, since it is in the coding region for the corresponding transcript. Segment cluster F10611_node_7 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611 T9, F10611_T10, F1O611_T11, F10611__T12, F10611_T13, F10611_T14, F10611 T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20 and F10611_T24. Table 394 below describes the starting and ending position of this segment on each transcript.

Table 394 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P10. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P3, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P8, F10611_P9, F1O611_P11, F10611_P12, F10611_P13, F10611_P14, F10611JP15, F10611_P16, F10611_P17, F10611_P18, F10611 P19 and F10611_P21, since it is in the coding region for the corresponding transcript.

Segment cluster F10611jnode_9 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F1061 1_T3, F10611 T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F1061 I_TlO, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20 and F10611_T24. Table 395 below describes the starting and ending position of this segment on each transcript.

Table 395 - Segment location on transcripts

This segment can be found h both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P10. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P3, F10611_P4, F10611_P5, F10611_P6, F10611JP7, F10611_P8, F10611_P9, F1O611_P11, F10611JP12, F10611_P13, F10611_P14, F10611_P15, F10611_P16, F10611_P17, F10611_P18, F10611_P19 and F10611_P21, since it is in the coding region for the corresponding transcript.

Segment cluster F10611jnode 13 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3,

F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10,

F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16,

F10611 T17, F10611_T19 and F1061 l_T20. Table 396 below describes the starting and ending position of this segment on each transcript.

Table 396 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F1061 IJPlO. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P3, F10611J^>4, F10611_P5, F10611_P6, F10611_P7, F10611_P8, F10611_P9, F10611JP11, F10611_P12, F10611JP13, F10611 P14, F10611_P15, F10611_P16, F10611_P17, F10611_P18 and F10611_P19, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_15 according to the present invention can be found in the following transcript(s): F10611__T11. Table 397 below describes the starting and ending position of this segment on each transcript.

Table 397 - Segment location on transcripts

This segment can be found in the following protein(s): F10611_P12.

Segment cluster F10611_node_20 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T8 and F10611_T10. Table 398 below describes the starting and ending position of this segment on each transcript.

Table 398 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Fl 061 IJPl 1. This segment can also be found in the following protein(s): F10611_P9, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_23 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T23. Table 399 below describes the starting and ending position of this segment on each transcript.

Table 399 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F 1061 l_P20.

Segment cluster F10611_node_28 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20, F10611_T21, F10611_T22, F10611_T23 and F10611_T31. Table 400 below describes the starting and ending position of this segment on each transcript.

Table 400 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P9, F10611JP11 and F10611_P12. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P3, F10611_P4, F10611_P5, F10611_P6, F10611JP7, ^~F10611_P8, π061 IJPlO, F10611_P13, F10611_P14, F10611J^»15, F10611JP16, F10611JP17, F10611_P18, F10611JP19, F10611_P20 and F 10611_P27, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_32 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611_Tl, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T7, F10611_T8, F10611_T9, F1061 I_TlO, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611JN6, F10611_T17, F10611_T19, F10611_T20, F10611_T21, F10611_T22, F10611_T23 and F10611_T31. Table 401 below describes the starting and ending position of this segment on each transcript.

Table 401 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611JP12, F10611_P20 and F10611_P27. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611JP6, F10611_P7, F10611JP8, F1061 IJPlO, F10611JP13, F10611JP14, F10611JP15, F10611_P16, F10611_P17, F10611_P18 and F10611_P19, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_33 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F1061 1_T12, F10611_T13, F10611_T14, F1061 1_T15, F10611_T16, F10611_T17, F10611_T19, F10611_T20, F10611_T21, F1061 1_T22, F10611_T23 and F10611_T31. Table 402 below describes the starting and ending position of this segment on each transcript.

Table 402 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611JP12, F10611_P20 and F10611JP27. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F1061 IJPlO, F10611JP13, F10611_P14, F10611_P15, F10611JP16, F10611JP17, F10611_P18 and F10611JP19, since it is in the coding region for the corresponding transcript. Segment cluster F10611_node_36 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T2, F10611_T8, F10611_T10, F1O611_T11, F10611_T21 and F10611_T23. Table 403 below describes the starting and ending position of this segment on each transcript.

Table 403 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611_P11, F10611_P12 and F10611_P20.

Segment cluster F10611_node_40 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611_Tl, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 404 below describes the starting and ending position of this segment on each transcript.

Table 404 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611JP3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_JP2, F10611_P4, F10611_P5, F10611_P6, F10611JP7, F1061 IJPlO, F10611JP13, F10611JP14, F10611JP15, F10611_P16, F10611_P17 and F10611_P18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_42 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 405 below describes the starting and ending position of this segment on each transcript.

Table 405 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611JP9, F1O611_P11, F10611JP12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611JP7, F1061 IJPlO, F10611JP13, F10611JP14, F10611JP15, F10611JP16, F10611_P17 and F10611JP18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_50 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F10611_T11, F10611_T12, F10611_T13, F10611__T14, F10611_T15, F10611_T16, F10611_T17, F 10611_T21 , F 10611_T22 and F 10611_T23. Table 406 below describes the starting and ending position of this segment on each transcript.

Table 406 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611_Pl l, F10611JP12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611JP5, F10611_P6, F10611_P7, F10611_P10, F10611_P13, F10611_P14, F10611JP15, F10611JP16, F10611_P17 and F10611_P18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_52 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F1061 1_T21, F10611_T22 and F10611_T23. Table 407 below describes the starting and ending position of this segment on each transcript.

Table 407 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611JP4, F10611_P5, F10611JP6, F10611_P7, F1061 IJPlO, F10611JP13, F10611_P14, F10611JP15, F10611_P16, F10611JP17 and F10611JP18, since i is in the coding region for the corresponding transcript.

Segment cluster F10611_node_54 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F1061 1_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F1061 1_T10, F10611_T11, F1061 1_T12, F10611_T13, F10611_T14, F10611_T15, F10611_T16, F10611_T17, F1061 1_T21, F10611_T22 and F10611_T23. Table 408 below describes the starting and ending position of this segment on each transcript.

Table 408 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F1061 IJPlO, F10611JP13, F10611_P14, F10611JP15, F10611JP16, F10611JP17 and F10611JP18, since it is in the coding region for the corresponding transcript. Segment cluster F10611_node_57 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F1061 1_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 409 below describes the starting and ending position of this segment on each transcript.

Table 409 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 410.

Table 410 - Oligonucleotides related to this segment

F10611 0 0 6663 lung malignant tumors LUN

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611JP2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P10, F10611JP13, F10611_P14, F10611JP16, F10611_P17 and F10611JP18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_61 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T17, F10611_T21, F10611_T22 and F10611_T23. Table 411 below describes the starting and ending position of this segment on each transcript.

Table 411 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F1061 1JP3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F1061 1_P29, F10611_P2, F10611_P4, F10611 P5, F10611 P6, F10611_P7, F10611_P10, F10611JP13, F10611JP14, F10611JP16, F10611 P17 and F10611_P18, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_64 according to the present invention can be found in the following transcript(s): F10611_T17. Table 412 below describes the starting and ending position of this segment on each transcript.

Table 412 - Segment location on transcripts

This segment can be found in the following protein(s): F10611_P18.

Segment cluster F10611_node_71 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F10611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T21, F10611_T22, F10611_T23 and F10611_T25. Table 413 below describes the starting and ending position of this segment on each transcript.

Table 413 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P10, F10611_P13, F10611_P14, F10611JP16, F10611_P17 and F10611_P22, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_75 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T21, F10611_T22, F10611_T23, F10611_T24 and F10611 _T25. Table 414 below describes the starting and ending position of this segment on each transcript.

Table 414 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611JP3, F10611_P9, F10611JP11, F10611JP12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611JP6, F10611_P7, F10611JP10, F10611JP13, F10611JP14, F10611_P16, F10611JP17, F10611_P21 and F10611_P22, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_77 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans criρt(s): F10611_T26. Table 415 below describes the starting and ending position of this segment on each transcript.

Table 415 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P23.

Segment cluster F10611_node_78 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0 and F10611_T26. Table 416 below describes the starting and ending position of this segment on each transcript.

Table 416 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P23. This segment can also be found in the following protein(s): F 10611_P29, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_79 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T 12, F10611_T13, F10611_T15, F10611_T16, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25 and F10611_T26. Table 417 below describes the starting and ending position of this segment on each transcript.

Table 417 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611JP9,^~ F10611_Pl l, F10611JP12, F10611_P20 and F10611_P23. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F10611_P10, F10611_P13, F10611JP14, F10611_P16, F10611JP17, F10611_P21 and F10611_P22, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_87 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F10611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T16, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25 and F10611_T26. Table 418 below describes the starting and ending position of this segment on each transcript.

Table 418 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P5, F10611_P6, F10611_P7, F1061 IJPlO, F10611_P13, F10611_P14, F10611JP16, F10611_P17, F10611JP21, F10611_P22 and F10611_P23, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_89 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T16. Table 419 below describes the starting and ending position of this segment on each transcript.

Table 419 - Segment location on transcripts

This segment can be found m the following protein(s): F10611_P17.

Segment cluster F10611_node_91 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T13, F10611_T15, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25 and F10611_T26. Table 420 below describes the starting and ending position of this segment on each transcript.

Table 420 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611JP2, F10611JP4, F10611_P5, F10611_P6, F10611_P7, F10611JP10, F10611_P13, F10611_P14, F10611_P16, F10611_P21, F10611_P22 and F10611_P23, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_98 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T3 and F10611_T4. Table 421 below describes the starting and ending position of this segment on each transcript.

Table 421 - Segment location on transcripts

This segment can be found in the following protein(s): F10611_P4 and F10611_P5.

Segment cluster F10611_node_100 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F106l l_Tll, F10611_T12, F10611_T13, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26 and F10611_T28. Table 422 below describes the starting and ending position of this segment on each transcript.

Table 422 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611JP3, F10611_P5, F10611_P9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P6, F10611_P7, F1061 IJPlO, F10611JP13, F10611JP14, F10611JP21, F10611JP22, F10611JP23 and F10611JP25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_107 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611JN0, F1O611_T11, F10611_T12, F10611_T13, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 423 below describes the starting and ending position of this segment on each transcript.

Table 423 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611_P6, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611_P4, F10611_P7, F10611_P10, F10611_P13, F10611JP14, F10611JP21, F10611_P22, F10611_P23, F10611_P24 and F10611_P25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_109 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T0, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611__T12, F10611_T13, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611 T27 and F10611_T28. Table 424 below describes the starting and ending position of this segment on each transcript.

Table 424 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611_P6, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611JP2, F10611_P4, F10611_P7, F1061 IJPlO, F10611_P13, F10611JP14, F10611_P21, F10611_P22, F10611JP23, F10611JP24 and F10611JP25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_node_113 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_TO, F1O611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O61 1_T11, F10611_T12, F10611_T13, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 425 below describes the starting and ending position of this segment on each transcript.

Table 425 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611JP6, F10611_P9, F10611JP11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611_P29, F10611_P2, F10611JP4, F10611_P7, F1061 IJPlO, F10611JP13, F10611_P14, F10611JP21, F10611_P22, F10611_P23, F10611JP24 and F10611_P25, since it is in the coding region for the corresponding transcript. Segment cluster F10611_node_114 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T13. Table 426 below describes the starting and ending position of this segment on each transcript.

Table 426 - Segment location on transcripts

This segment can be found in the following protein(s): F10611_P14.

Segment cluster F10611_node_116 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript®: F10611_T0, F10611_T1, F10611_T2, F10611_T3, F10611_T4, F10611_T5, F10611_T6, F10611_T8, F10611_T9, F10611_T10, F1O611_T11, F10611_T12, F10611_T21, F10611_T22, F10611_T23, F10611_T24, F10611_T25, F10611_T26, F10611_T27 and F10611_T28. Table 427 below describes the starting and ending position of this segment on each transcript.

Table 427 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F10611_P3, F10611_P5, F10611_P6, F10611_P9, F1O611_P11, F10611_P12 and F10611_P20. This segment can also be found in the following protein(s): F10611JP29, F10611_P2, F10611_P4, F10611_P7, F1061 IJPlO, F10611JP13, F10611_P21, F10611JP22, F10611_P23, F10611_P24 and F10611JP25, since it is in the coding region for the corresponding transcript.

Segment cluster F10611_jnode_117 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T12. Table 428 below describes the starting and ending position of this segment on each transcript.

Table 428 - Segment location on transcripts

This segment can be found in the following protein(s): F10611JP13.

Segment cluster F10611_node_121 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F10611_T6. Table 429 below describes the starting and ending position of this segment on each transcript.

Table 429 - Segment location on transcripts

This segment can be found in the following protein(s): F10611_P7.

DESCRIPTION FOR CLUSTER H41850

Cluster H41850 features 1 transcript(s) and 22 segment(s) of interest, the names for which are given in Tables 430 and 431, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 432.

Table 430 - Transcripts of interest

Transcript Name

H41850 T5

Table 431 - Segments of interest

Segment Name

H41850 node 0

H41850 node 3

H41850 node 11

H41850 node 16

H41850 node 24

H41850 node 34

H41850 node 36

H41850 node 37

H41850 node 5

H41850 node 6

H41850 node 7

H41850 node 8

H41850 node 12

H41850 node 15

H41850 node 17

H41850 node 18 H41850 node 22

H41850 node 25

H41850 node 26

H41850 node 28

H41850 node 29

H41850 node 30

Table 432 - Proteins of interest

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 433.

Table 433 - Oligonucleotides related to this cluster

As noted above, cluster H41850 features 22 segment(s), which were listed in Table 431 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster H41850_node_0 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 434 below describes the starting and ending position of this segment on each transcript. Table 434 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H41850_P6.

Segment cluster H41850_node_3 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 435 below describes the starting and ending position of this segment on each transcript.

Table 435 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H41850_P6.

Segment cluster H41850_node_l l according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 436 below describes the starting and ending position of this segment on each transcript.

Table 436 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H41850_P6. Segment cluster H41850_node_16 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): H41850_T5. Table 437 below describes the starting and ending position of this segment on each transcript.

Table 437 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6.

Segment cluster H41850_node_24 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 438 below describes the starting and ending position of this segment on each transcript.

Table 438 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6.

Segment cluster H41850_node_34 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 439 below describes the starting and ending position of this segment on each transcript.

Table 439 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6. Segment cluster H41850_node_36 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 440 below describes the starting and ending position of this segment on each transcript.

Table 440 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6.

Segment cluster H41850_node_37 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 441 below describes the starting and ending position of this segment on each transcript.

Table 441 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster H41850_node_5 according to the present invention can be found in the following transcript(s): H41850_T5. Table 442 below describes the starting and ending position of this segment on each transcript. Table 442 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H41850JP6.

Segment cluster H41850_node_6 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 443 below describes the starting and ending position of this segment on each transcript.

Table 443 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H41850_P6.

Segment cluster H41850_node_7 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 444 below describes the starting and ending position of this segment on each transcript.

Table 444 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H41850_P6. Segment cluster H41850_node_8 according to the present invention can be found in the following transcript(s): H41850_T5. Table 445 below describes the starting and ending position of this segment on each transcript.

Table 445 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H41850_P6.

Segment cluster H41850_node_12 according to the present invention can be found in the following transcript(s): H41850_T5. Table 446 below describes the starting and ending position of this segment on each transcript.

Table 446 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H41850_P6.

Segment cluster H41850_node_15 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 447 below describes the starting and ending position of this segment on each transcript.

Table 447 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H41850_P6. Segment cluster H41850_node_17 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 448 below describes the starting and ending position of this segment on each transcript.

Table 448 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6.

Segment cluster H41850_node_ 18 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 449 below describes the starting and ending position of this segment on each transcript.

Table 449 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6.

Segment cluster H41850_node_22 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 450 below describes the starting and ending position of this segment on each transcript.

Table 450 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6. Segment cluster H41850_node_25 according to the present invention can be found in the following transcπpt(s): H41850_T5. Table 451 below describes the starting and ending position of this segment on each transcript Table 451 - Segment location on transcripts

This segment can be found in the following protein(s): H41850JP6.

Segment cluster H41850_node_26 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 452 below describes the starting and ending position of this segment on each transcript

Table 452 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6.

Segment cluster H41850_node_28 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 453 below describes the starting and ending position of this segment on each transcript.

Table 453 - Segment location on transcripts

This segment can be found in the following protein(s): H41850JP6. Segment cluster H41850_node_29 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 454 below describes the starting and ending position of this segment on each transcript.

Table 454 - Segment location on transcripts

This segment can be found in the following protein(s): H41850JP6.

Segment cluster H41850_node_30 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H41850_T5. Table 455 below describes the starting and ending position of this segment on each transcript.

Table 455 - Segment location on transcripts

This segment can be found in the following protein(s): H41850_P6.

DESCRIPTION FOR CLUSTER HSB6PR

Cluster HSB6PR features 3 transcript(s) and 17 segment(s) of interest, the names for which are given in Tables 456 and 457, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 458.

Table 456 - Transcripts of interest

Transcript Name

HSB6PR T2

HSB6PR T4

HSB6PR T6 Table 457 - Segments of interest

Segment Hame

HSB6PR node 1

HSB6PR node 6

HSB6PR node 10

HSB6PR node 12

HSB6PR node 14

HSB6PR node 15

HSB6PR node 17

HSB6PR node 32

HSB6PR node 35

HSB6PR node 37

HSB6PR node 39

HSB6PR node 0

HSB6PR node 4

HSB6PR node 8

HSB6PR node _33

HSB6PR node 36

HSB6PR node 38

Table 458 - Proteins of interest

These sequences are variants of the known protein Plakophilin 1 (SwissProt accession identifier PKP1_HUMAN; known also according to the synonyms Band-6-protein; B6P), referred to herein as the previously known protein.

Protein Plakophilin 1 is known or believed to have the following function(s): SEEMS TO PLAY A ROLE IN JUNCTIONAL PLAQUES. The sequence for protein Plakophilin 1 is given at the end of the application, as "Plakophilin 1 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 459.

Table 459 - Amino acid mutations for Known Protein

Protein Plakophilin 1 localization is believed to be Nuclear. Isoform 1 is also associated with desmosomes.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell adhesion; signal transduction, which are annotation(s) related to Biological Process; intermediate filament binding; structural protein of epidermis, which are annotation(s) related to Molecular Function; and nucleus; cytoskeleton; desmosome, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nkn.nih.gov/projects/LocusLink/>.

Cluster HSB6PR can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 15 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 15 and Table 460. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: a mixture of malignant tumors from different tissues.

Table 460 - Normal tissue distribution

Table 461 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSB6PR features 17 segment(s), which were listed in Table 457 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSB6PR_node_l according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T4. Table 462 below describes the starting and ending position of this segment on each transcript.

Table 462 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PR_P4.

Segment cluster HSB6PR_node_6 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T4. Table 463 below describes the starting and ending position of this segment on each transcript.

Table 463 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PR_P4.

Segment cluster HSB6PR_node_10 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T4 and HSB6PR_T6. Table 464 below describes the starting and ending position of this segment on each transcript. Table 464 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PR_P4 and HSB6PR_P6.

Segment cluster HSB6PR_node_12 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T4 and HSB6PR_T6. Table 465 below describes the starting and ending position of this segment on each transcript.

Table 465 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PR_P4 and HSB6PR_P6.

Segment cluster HSB6PR_node_14 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR T4 and HSB6PR T6. Table 466 below describes the starting and ending position of this segment on each transcript.

Table 466 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PR_P4 and HSB6PRJP6.

Segment cluster HSB6PR_node_15 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T4. Table 467 below describes the starting and ending position of this segment on each transcript.

Table 467 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PR_P4.

Segment cluster HSB6PR_node_17 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T6. Table 468 below describes the starting and ending position of this segment on each transcript

Table 468 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PR_P6.

Segment cluster HSB6PR_node_32 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PRJT2. Table 469 below describes the starting and ending position of this segment on each transcript.

Table 469 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSB6PRJ?2. Segment cluster HSB6PR_node_35 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T2. Table 470 below describes the starting and ending position of this segment on each transcript.

Table 470 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSB6PR_P2.

Segment' cluster HSB6PR_node_37 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR T2. Table 471 below describes the starting and ending position of this segment on each transcript.

Table 471 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 472.

Table 472 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HSB6PR_P2. Segment cluster HSB6PR_node_39 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR T2. Table 473 below describes the starting and ending position of this segment on each transcript.

Table 473 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSB6PRJP2.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSB6PR_node_0 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T4. Table 474 below describes the starting and ending position of this segment on each transcript.

Table 474 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSB6PR_P4.

Segment cluster HSB6PR_node_4 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T4. Table 475 below describes the starting and ending position of this segment on each transcript.

Table 475 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PRJP4.

Segment cluster HSB6PR_node_8 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T6. Table 476 below describes the starting and ending position of this segment on each transcript.

Table 476 - Segment location on transcripts

This segment can be found in the following protein(s): HSB6PR_P6.

Segment cluster HSB6PR_node_33 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T2. Table 477 below describes the starting and ending position of this segment on each transcript.

Table 477 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSB6PRJP2. Segment cluster HSB6PR_node_36 according to the present invention can be found in the following transcript(s): HSB6PR T2. Table 478 below describes the starting and ending position of this segment on each transcript.

Table 478 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following ρrotein(s): HSB6PR_P2.

Segment cluster HSB6PR_node_38 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSB6PR_T2. Table 479 below describes the starting and ending position of this segment on each transcript.

Table 479 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSB6PR_P2.

DESCRIPTION FOR CLUSTER HSBMYB

Cluster HSBMYB features 3 transcript(s) and 36 segment(s) of interest, the names for which are given in Tables 480 and 481, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 482.

Table 480 - Transcripts of interest

Transcript Name

HSBMYB T23

HSBMYB T24

HSBMYB T26 Table 481 - - Segments of interest

Segment Name

HSBMYB node 0

HSBMYB node 11

HSBMYB node 15

HSBMYB node 18

HSBMYB node 21

HSBMYB node 22

HSBMYB node 25

HSBMYB node 26

HSBMYB node 28

HSBMYB node 33

HSBMYB node 40

HSBMYB node 47

HSBMYB node 50

HSBMYB node 52

HSBMYB node 2

HSBMYB node 5

HSBMYB node 7

HSBMYB node 8

HSBMYB node 17

HSBMYB node 29

HSBMYB node 30

HSBMYB node 31

HSBMYB node 32

HSBMYB node 34

HSBMYB_ node _35

HSBMYB node 36

HSBMYB node 37

HSBMYB node 38

HSBMYB node 41

HSBMYB node 42

HSBMYB node 46

HSBMYB node 49

HSBMYB node 51

HSBMYB node 53

HSBMYB node 54

HSBMYB node 55

Table 482 - Proteins of interest

These sequences are variants of the known protein Myb -related protein B (SwissProt accession identifier MYBB_HUMAN; known also according to the synonyms B-Myb), referred to herein as the previously known protein. The sequence for protein Myb-related protein B is given at the end of the application, as

"Myb-related protein B amino acid sequence". Protein Myb-related protein B localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell cycle control; transcription regulation; transcription, from Pol II promoter; anttapoptosis; developmental processes, which are annotation(s) related to Biological

Process; transcription factor, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster HSBMYB can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 16 and Table 483. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, kidney malignant tumors, myosarcoma, ovarian carcinoma, pancreas carcinoma, skin malignancies and uterine malignancies.

Table 483 - Normal tissue distribution

Table 484 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSBMYB features 36 segment(s), which were listed in Table 481 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSBMYB_node_0 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 485 below describes the starting and ending position of this segment on each transcript. Table 485 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB JP20.

Segment cluster HSBMYB_node_l 1 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found m the following transcript(s): HSBMYB_T23. Table 486 below describes the starting and ending position of this segment on each transcript.

Table 486 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_15 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 487 below describes the starting and ending position of this segment on each transcript.

Table 487 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_l 8 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 488 below describes the starting and ending position of this segment on each transcript.

Table 488 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_21 according to the present invention is supported by libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 489 below describes the starting and ending position of this segment on each transcript.

Table 489 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_22 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 490 below describes the starting and ending position of this segment on each transcript.

Table 490 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_25 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 491 below describes the starting and ending position of this segment on each transcript.

Table 491 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_26 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 492 below describes the starting and ending position of this segment on each transcript.

Table 492 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_28 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24. Table 493 below describes the starting and ending position of this segment on each transcript.

Table 493 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21.

Segment cluster HSBMYB_node_33 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24. Table 494 below describes the starting and ending position of this segment on each transcript.

Table 494 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21. Segment cluster HSBMYB_node_40 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T26. Table 495 below describes the starting and ending position of this segment on each transcript.

Table 495 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSBMYB_P23.

Segment cluster HSBMYB_node_47 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 496 below describes the starting and ending position of this segment on each transcript.

Table 496 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21 and HSBMYB P23.

Segment cluster HSBMYB_node_50 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 497 below describes the starting and ending position of this segment on each transcript.

Table 497 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21 and HSBMYB_P23.

Segment cluster HSBMYB_node_52 according to the present invention is supported by

127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 498 below describes the starting and ending position of this segment on each transcript.

Table 498 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21 and HSBMYB_P23.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSBMYB_node_2 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HSBMYB_T23. Table 499 below describes the starting and ending position of this segment on each transcript.

Table 499 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20. Segment cluster HSBMYB_node_5 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 500 below describes the starting and ending position of this segment on each transcript.

Table 500 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_7 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB T23. Table 501 below describes the starting and ending position of this segment on each transcript.

Table 501 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_8 according to the present invention can be found in the following transcript(s): HSBMYB_T23. Table 502 below describes the starting and ending position of this segment on each transcript.

Table 502 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20. Segment cluster HSBMYB_node_17 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T23. Table 503 below describes the starting and ending position of this segment on each transcript.

Table 503 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P20.

Segment cluster HSBMYB_node_29 according to the present invention can be found in the following transcript(s): HSBMYB T24. Table 504 below describes the starting and ending position of this segment on each transcript.

Table 504 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21.

Segment cluster HSBMYB_node__30 according to the present invention can be found in the following transcript(s): HSBMYB_T24. Table 505 below describes the starting and ending position of this segment on each transcript. Table 505 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21. Segment cluster HSBMYB_node_31 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24. Table 506 below describes the starting and ending position of this segment on each transcript.

Table 506 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21.

Segment cluster HSBMYB_node_32 according to the present invention can be found in the following transcript(s): HSBMYB_T24. Table 507 below describes the starting and ending position of this segment on each transcript.

Table 507 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21.

Segment cluster HSBMYB_node_34 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24. Table 508 below describes the starting and ending position of this segment on each transcript.

Table 508 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21. Segment cluster HSBMYB_node_35 according to the present invention can be found in the following Iranscript(s): HSBMYB_T24. Table 509 below describes the starting and ending position of this segment on each transcript. Table 509 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21.

Segment cluster HSBMYB_node_36 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24. Table 510 below describes the starting and ending position of this segment on each transcript.

Table 510 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21.

Segment cluster HSBMYB_node_37 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24. Table 511 below describes the starting and ending position of this segment on each transcript.

Table 511 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21. Segment cluster HSBMYB_node_38 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24. Table 512 below describes the starting and ending position of this segment on each transcript.

Table 512 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21.

Segment cluster HSBMYB_node_41 according to the present invention can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 513 below describes the starting and ending position of this segment on each transcript.

Table 513 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSBMYB_P23. This segment can also be found in the following protein(s): HSBMYB_P21, since it is in the coding region for the corresponding transcript.

Segment cluster HSBMYB_node_42 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 514 below describes the starting and ending position of this segment on each transcript.

Table 514 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21 and HSBMYB_P23.

Segment cluster HSBMYB_node_46 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 515 below describes the starting and ending position of this segment on each transcript.

Table 515 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYB_P21 and HSBMYB P23.

Segment cluster HSBMYB_node_49 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 516 below describes the starting and ending position of this segment on each transcript.

Table 516 - Segment location on transcripts

This segment can be found in the following protein(s): HSBMYBJP21 and HSBMYB P23. Segment cluster HSBMYB_node_51 according to the present invention can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 517 below describes the starting and ending position of this segment on each transcript.

Table 517 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21 and HSBMYB_P23.

Segment cluster HSBMYB_node_53 according to the present invention can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 518 below describes the starting and ending position of this segment on each transcript.

Table 518 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21 and HSBMYB_P23.

Segment cluster HSBMYB_node_54 according to the present invention is supported by 118 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 519 below describes the starting and ending position of this segment on each transcript.

Table 519 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21 and HSBMYB_P23.

Segment cluster HSBMYB_node_55 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSBMYB_T24 and HSBMYB_T26. Table 520 below describes the starting and ending position of this segment on each transcript.

Table 520 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSBMYB_P21 and HSBMYB_P23. DESCRIPTION FOR CLUSTER HSCALLA

Cluster HSCALLA features 10 transcript(s) and 36 segment(s) of interest, the names for which are given in Tables 521 and 522, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 523.

Table 521 - Transcripts of interest

Transcript Name

HSCALLA T6

HSCALLA T7

HSCALLA T8

HSCALLA T9

HSCALLA TlO

HSCALLA T12

HSCALLA T14

HSCALLA T20

HSCALLA T24

HSCALLA T26

Table 522 - Segments of interest Segment Name

HSCALLA node 0

HSCALLA node 6

HSCALLA node 8

HSCALLA node 11

HSCALLA node 13

HSCALLA node 15

HSCALLA node 16

HSCALLA node 18

HSCALLA node 23

HSCALLA node 25

HSCALLA node 26

HSCALLA node 27

HSCALLA node 30

HSCALLA node 40

HSCALLA node 42

HSCALLA node 46

HSCALLA node 50

HSCALLA node 60

HSCALLA node 63

HSCALLA node 78

HSCALLA node 2

HSCALLA node 7

HSCALLA node 20

HSCALLA node 33

HSCALLA node _.35

HSCALLA node 37

HSCALLA node 39

HSCALLA node 44

HSCALLA node 48

HSCALLA node 52

HSCALLA node 54

HSCALLA node 56

HSCALLA node 58

HSCALLA node 65

HSCALLA node 69

HSCALLA node 71

Table 523 - Proteins of interest

These sequences are variants of the known protein Neprilysin (SwissProt accession identifier NEP_HUMAN; known also according to the synonyms EC 3.4.24.11; Neutral endopeptidase; NEP; Enkephalinase; Common acute lymphocytic leukemia antigen; CALLA; Neutral endopeptidase 24.11 ; CDl 0), referred to herein as the previously known protein.

Protein Neprilysin is known or believed to have the following function(s): Thermolysin- like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu- enkephalins by cleavage of a Gly-Phe bond. The sequence for protein Neprilysin is given at the end of the application, as "Neprilysin amino acid sequence". Known polymorphisms for this sequence are as shown in Table 524.

Table 524 - Amino acid mutations for Known Protein

Protein Neprilysin localization is believed to be Type II membrane protein.

The previously known protein also has the following indication(s) and/or potential therapeutic use(s): Inflammation. It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Enkephalinase stimulant. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication." Ophthalmological; GI inflammatory/bowel disorders; Anti- inflammatory; Anticancer; Antimigraine.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: proteolysis and peptidolysis; cell-cell signaling, which are annotation(s) related to Biological Process; metallopeptidase, which are annotation(s) related to Molecular Function; and integral plasma membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HSCALLA can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 17 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 17 and Table 525. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: adrenal cortical carcinoma.

Table 525 - Normal tissue distribution

Table 526 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSCALLA features 36 segment(s), which were listed in Table 522 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSCALLA_node_0 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6. Table 527 below describes the starting and ending position of this segment on each transcript.

Table 527 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSCALLA_P11.

Segment cluster HSCALLA_node_6 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T12, HSCALLA_T24 and HSCALLA_ T26. Table 528 below describes the starting and ending position of this segment on each transcript.

Table 528 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P2, HSCALLA_P8 and HSCALLA_P9.

Segment cluster HSCALLA_node_8 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLAJT12, HSCALLA_T24 and HSCALLA_T26. Table 529 below describes the starting and ending position of this segment on each transcript.

Table 529 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P2, HSCALLA_P8 and HSCALLA_P9. Segment cluster HSCALLA_node_l 1 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T10. Table 530 below describes the starting and ending position of this segment on each transcript.

Table 530 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P11.

Segment cluster HSCALLA_node_13 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T9. Table 531 below describes the starting and ending position of this segment on each transcript.

Table 531 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P11.

Segment cluster HSCALLA_node_15 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T7 and HSCALLA_T8. Table 532 below describes the starting and ending position of this segment on each transcript.

Table 532 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA P11.

Segment cluster HSCALLA_node_16 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T7. Table 533 below describes the starting and ending position of this segment on each transcript.

Table 533 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLAJP11.

Segment cluster HSCALLA_node_l 8 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_T10, HSCALLA_T12, HSCALLA_T20, HSCALLA_T24 and HSCALLA_T26. Table 534 below describes the starting and ending position of this segment on each transcript. Table 534 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P2. This segment can also be found in the following protein(s): HSCALLA_P11, HSCALLAJP1, HSCALLA_P8 and HSCALLA_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HSCALLA_node_23 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T26. Table 535 below describes the starting and ending position of this segment on each transcript.

Table 535 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P9.

Segment cluster HSCALLA_node_25 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T14. Table 536 below describes the starting and ending position of this segment on each transcript. Table 536 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSCALLAJP4. Segment cluster HSCALLA_node_26 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T12 and HSCALLA_T14. Table 537 below describes the starting and ending position of this segment on each transcript.

Table 537 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P4. This segment can also be found in the following protein(s): HSCALLAJP2, since it is in the coding region for the corresponding transcript.

Segment cluster HSCALLA_node_27 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in4he following transcript(s): HSCALLA_T14. Table 538 below describes the starting and ending position of this segment on each transcript.

Table 538 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P4.

Segment cluster HSCALLA_node_30 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14, HSCALLA_T20 and HSCALLA_T24. Table 539 below describes the starting and ending position of this segment on each transcript.

Table 539 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P11, HSCALLA_P2, HSCALLA_P4, HSCALLA_P1 and HSCALLA_P8.

Segment cluster HSCALLA_node_40 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T24. Table 540 below describes the starting and ending position of this segment on each transcript.

Table 540 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P8.

Segment cluster HSCALLA_node_42 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_T10, HSCALLAJ12, HSCALLA_T14 and HSCALLA_T20. Table 541 below describes the starting and ending position of this segment on each transcript. Table 541 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJP11, HSCALLA_P2, HSCALLA P4 and HSCALLA Pl.

Segment cluster HSCALLA_node_46 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 542 below describes the starting and ending position"of this segment on-each transcript.-

Table 542 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJP11, HSCALLA_P2, HSCALLA P4 and HSCALLA Pl. Segment cluster HSCALLA_node_50 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA _T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_T10, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 543 below describes the starting and ending position of this segment on each transcript.

Table 543 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P11, HSCALLA_P2, HSCALLA_P4 and HSCALLA_P1.

Segment cluster HSCALLA_node_60 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_T10, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 544 below describes the starting and ending position of this segment on each transcript.

Table 544 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA-Pl 1, HSCALLA_P2, HSCALLA_P4 and HSCALLA_P1.

Segment cluster HSCALLA_node_63 according to the present invention is supported by

31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 545 below describes the starting and ending position of this segment on each transcript. Table 545 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P11, HSCALLA_P2, HSCALLA P4 and HSCALLA Pl.

Segment cluster HSCALLA_node_78 according to the present invention is supported by

247 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 546 below describes the starting and ending position of this segment on each transcript. Table 546 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJPl l, HSCALLA_P2, HSCALLA P4 and HSCALLA Pl.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSCALLA_node_2 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T20. Table 547 below describes the starting and ending ppsition_^pf this segment on each transcript.

Table 547 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P1.

Segment cluster HSCALLA_node_7 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T 12, HSCALLA_T24 and HSCALLA_T26. Table 548 below describes the starting and ending position of this segment on each transcript.

Table 548 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P2, HSCALLAJP8 and HSCALLA_P9.

Segment cluster HSCALLA_node_20 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_T10, HSCALLA_T12, HSCALLA_T20, HSCALLA_T24 and HSCALLA_T26. Table 549 below describes the starting and ending position of this segment on each transcript.

Table 549 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCALLA_P2. This segment can also be found in the following protein(s): HSCALLAJP11, HSCALLAJP1, HSCALLA_P8 and HSCALLA_P9, since it is in the coding region for the corresponding transcript. Segment cluster HSCALLA_node_33 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14, HSCALLA_T20 and HSCALLA_T24. Table 550 below describes the starting and ending position of this segment on each transcript.

Table 550 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA J?11,_HSCALLA_P2, HSCALLA P4, HSCALLA_P1 and HSCALLA_P8.

Segment cluster HSCALLA_node_35 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA T8, HSCALLA_T9, HSCALLA_T10, HSCALLA_T12, HSCALLA_T14, HSCALLA_T20 and HSCALLA T24. Table 551 below describes the starting and ending position of this segment on each transcript.

Table 551 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJP11, HSCALLA_P2, HSCALLA_P4, HSCALLA_P1 and HSCALLA_P8.

Segment cluster HSCALLA_node_37 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14, HSCALLA_T20 and HSCALLA_T24. Table 552 below describes the starting and ending position of this segment on each transcript.

Table 552 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P11, HSCALLA J^>2, HSCALLA_P4, HSCALLA_P1 and HSCALLA_P8.

Segment cluster HSCALLA_node_39 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA__T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14, HSCALLA_T20 and HSCALLA_T24. Table 553 below describes the starting and ending position of this segment on each transcript.

Table 553 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P11, HSCALLA P2, HSCALLA_P4, HSCALLA_P1 and HSCALLA_P8.

Segment cluster HSCALLA_node_44 according to the present invention is supported by

24 libraries. The number of libraries was determined as previously described. JThis_ segment, can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8,

HSCALLA_T9, HSCALLA_T10, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20.

Table 554 below describes the starting and ending position of this segment on each transcript.

Table 554 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P11, HSCALLA_P2, HSCALLA P4 and HSCALLA Pl. Segment cluster HSCALLA_node_48 according to the present invention is supported by

24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_T10, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20.

Table 555 below describes the starting and ending position of this segment on each transcript.

Table 555 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJP11, HSCALLA_P2, HSCALLA- P4 and HSCALLA Pl.

Segment cluster HSCALLA_node_52 according to the present invention is supported by

24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20.

Table 556 below describes the starting and ending position of this segment on each transcript.

Table 556 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJP11, HSCALLA_P2, HSCALLA_P4 and HSCALLAJP 1.

Segment cluster HSCALLA_node_54 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 557 below describes the starting and ending position of this segment on each transcript.

Table 557 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJP11, HSCALLAJP2, HSCALLA P4 and HSCALLA Pl.

Segment cluster HSCALLA_node_56 according to the present invention is supported by

29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLAJNO, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 558 below describes the starting and ending position of this segment on each transcript. Table 558 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJP11, HSCALLA_P2, HSCALLA_P4 and HSCALLA_P1.

Segment cluster HSCALLA_node_58 according to the present invention is supported by

30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 559 below describes the starting and ending position of this segment on each transcript. ' Table 559 - Segment location on transcripts ^{~ ~ ~ ~ "} - - -

This segment can be found in the following protein(s): HSCALLA_P11, HSCALLA_P2, HSCALLA P4 and HSCALLA Pl.

Segment cluster HSCALLA_node_65 according to the present invention is supported by

25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9₅ HSCALLA_TIO, HSCALLA_T12, HSCALLA_T14 and HSCALLA_T20. Table 560 below describes the starting and ending position of this segment on each transcript.

Table 560 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLAJP11, HSCALLA_P2, HSCALLA P4 and HSCALLA Pl.

Segment cluster HSCALLA_node_69 according to the present invention is supported by

32 libraries. The number of libraries was determined as previously described. This segment can -be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8,

HSCALLA_T9, HSCALLA_T10, HSCALLA_T12, HSCALLA J14 and HSCALLA_T20.

Table 561 below describes the starting and ending position of this segment on each transcript.

Table 561 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA_P11, HSCALLA_P2, HSCALLA P4 and HSCALLA Pl. Segment cluster HSCALLA_node_71 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCALLA_T6, HSCALLA_T7, HSCALLA_T8, HSCALLA_T9, HSCALLA_T10, HSCALLAJN2, HSCALLA_T14 and HSCALLA_T20. Table 562 below describes the starting and ending position of this segment on each transcript.

Table 562 - Segment location on transcripts

This segment can be found in the following protein(s): HSCALLA-PI l, HSCALLA_P2, -HSCALLA_P4 and HSCALLA-Pl.

DESCRIPTION FOR CLUSTER HSCD44E

Cluster HSCD44E features 30 transcript(s) and 66 segment(s) of interest, the names for which are given in Tables 563 and 564, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 565.

Table 563 - Transcripts of interest

Transcript Name

HSCD44E Tl

HSCD44E T3

HSCD44E T6

HSCD44E T7

HSCD44E T8

HSCD44E TlO

HSCD44E T12

HSCD44E T13 HSCD44E T16

HSCD44E T22

HSCD44E T26

HSCD44E T32

HSCD44E T34

HSCD44E T35

HSCD44E T36

HSCD44E T38

HSCD44E T39

HSCD44E T40

HSCD44E T45

HSCD44E T46

HSCD44E T47

HSCD44E T57

HSCD44E T63

HSCD44E T65

HSCD44E T68

HSCD44E T69

HSCD44E T72

HSCD44E T73

HSCD44E T82

HSCD44E T83

Table 564 - Segments of interest

Segment Name

HSCD44E node 0

HSCD44E node 4

HSCD44E node 6

HSCD44E node 16

HSCD44E node 23

HSCD44E node 29

HSCD44E node 32

HSCD44E node 34

HSCD44E node 35

HSCD44E node 36

HSCD44E node 39

HSCD44E node 41

HSCD44E node 46

HSCD44E node 48

HSCD44E node 50

HSCD44E node 52

HSCD44E node 53

HSCD44E node 54 HSCD44E node 55

HSCD44E node 57

HSCD44E node 61

HSCD44E node 66

HSCD44E node 68

HSCD44E node 69

HSCD44E node 73

HSCD44E node 90

HSCD44E node 92

HSCD44E node 93

HSCD44E node 94

HSCD44E node 2

HSCD44E node 7

HSCD44E node 8

HSCD44E node 10

HSCD44E node 11

HSCD44E node 12

HSCD44E node 13

HSCD44E node 17

HSCD44E node 18

HSCD44E node 19

HSCD44E node 20

HSCD44E node 24

HSCD44E node 25

HSCD44E node 30

HSCD44E_ node 31

HSCD44E node 37

HSCD44E node 40

HSCD44E node 42

HSCD44E node 43

HSCD44E node 47

HSCD44E node 49

HSCD44E node 58

HSCD44E node 59

HSCD44E node 64

HSCD44E node 65

HSCD44E node 67

HSCD44E node 74

HSCD44E node 75

HSCD44E node 77

HSCD44E node _79

HSCD44E node 80

HSCD44E node 82

HSCD44E node 83 HSCD44E node 84

HSCD44E node 85

HSCD44E node 86

HSCD44E node 91

Table 565 - Proteins of interest

These sequences are variants of the known protein CD44 antigen precursor (SwissProt accession identifier CD44_HUMAN; known also according to the synonyms Phagocytic glycoprotein I; PGP-I; HUTCH-I; Extracellular matrix receptor-III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; Hyaluronate receptor; Heparan sulfate proteoglycan; Epican; CDw44), referred to herein as the previously known protein.

Protein CD44 antigen precursor is known or believed to have the following function(s): Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix matalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopofesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. The sequence for protein CD44 antigen precursor is given at the end of the application, as "CD44 antigen precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 566.

Table 566 - Amino acid mutations for Known Protein

Protein CD44 antigen precursor localization is believed to be Type I membrane protein.

It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related — activity or activities of the previously known protein are as follows: CD44 antagonist; DNA ^■ antagonist. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Anticancer; Immunoconjugate; Antiinflammatory; Antiarthritic, immunological; Monoclonal antibody, humanized.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell adhesion; cell-matrix adhesion; cell-cell adhesion, which are annotation(s) related to Biological Process; receptor; collagen binding; hyaluronic acid binding, which are annotation(s) related to Molecular Function; and integral plasma membrane protein; membrane, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhri.nih.gov/projects/LocusLink/>. Cluster HSCD44E can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 18 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 18 and Table 567. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors and gastric carcinoma.

Table 567 - Normal tissue distribution

Table 568 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSCD44E features 66 segment(s), which were listed in Table 564 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSCD44E_node_0 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following trarecript(s): HSCD44E_T35, HSCD44E_T82 and HSCD44E_T83. Table 569 below describes the starting and ending position of this segment on each transcript.

Table 569 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2.

Segment cluster HSCD44E_node_4 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T82 and HSCD44E_T83. Table 570 below describes the starting and ending position of this segment on each transcript.

Table 570 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSCD44E_node_6 according to the present invention is supported by 133 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_ T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T38, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 571 below describes the starting and ending position of this segment on each transcript.

Table 571 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44E_P10, HSCD44E_P18 and HSCD44E_P40. This segment can also be found in the following protein(s): HSCD44E_P41, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_16 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T36. Table 572 below describes the starting and ending position of this segment on each transcript.

Table 572 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2.

Segment cluster HSCD44E_node_23 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T39. Table 573 below describes the starting and ending position of this segment on each transcript.

Table 573 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2.

Segment cluster HSCD44E_node_29 according to the present invention is supported by 204 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 574 below describes the starting and ending position of this segment on each transcript.

Table 574 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcriρt(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44EJP41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44EJP6, HSCD44EJP8, HSCD44E_P10 and HSCD44EJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_32 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T72 and HSCD44E_T73. Table 575 below describes the starting and ending position of this segment on each transcript.

Table 575 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of trans cript(s) that are related to the following protein(s): HSCD44E_P41. This segment can also be found in the following protein(s): HSCD44E_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_34 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T32. Table 576 below describes the starting and ending position of this segment on each transcript.

Table 576 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSCD44E_node_35 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68 and HSCD44E_T69. Table 577 below describes the starting and ending position of this segment on each transcript.

Table 577 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2 and HSCD44EJP18. This segment can also be found in the following protein(s): HSCD44E_P10, since it is in the coding legion for the corresponding transcript.

Segment cluster HSCD44E_node_36 according to the present invention is supported by

29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H8CD44E_T1, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34,

HSCD44E_T35, HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65,

HSCD44E_T68 and HSCD44E_T69. Table 578 below describes the starting and ending

-position of this segment on each transcript. Table 578 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2 and HSCD44E P18. This segment can also be found in the following protein(s): HSCD44E_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_39 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44EJN2, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68 and HSCD44E_T69. Table 579 below describes the starting and ending position of this segment on each transcript. Table 579 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18. Segment cluster HSCD44E_node_41 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously descπbed. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68 and HSCD44E_T69. Table 580 below describes the starting and ending position of this segment on each transcript.

Table 580 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18.

Segment cluster HSCD44E_node_46 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T40. Table 581 below describes the starting and ending position of this segment on each transcript.

Table 581 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2.

Segment cluster HSCD44E_node_48 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_ T1, HSCD44E_T7, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E T22, HSCD44E_T26, HSCD44E_T32, HSCD44E T34, HSCD44E T35, HSCD44E_T36, HSCD44E_T39, HSCD44E_T40, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68 and HSCD44E_T69. Table 582 below describes the starting and ending position of this segment on each transcript.

Table 582 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44EJP10 and HSCD44E_P18. Segment cluster HSCD44E_node_50 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T69. Table 583 below describes the starting and ending position of this segment on each transcript.

Table 583 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44EJP10.

Segment cluster HSCD44E_node_52 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44EJN3, HSϋD44E_Tr67 ^~ΗSCD44E_T22,— HSCD44E_T26/ HSCD44E_T32, ^~ HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 584 below describes the starting and ending position of this segment on each transcript.

Table 584 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44EJP10 and HSCD44E_P18. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6 and HSCD44E_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_53 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be^~~ found^" in^" the following transcript(s): -HSCD44E_Tl^', - HSCD44E1T3, HSCD44E_T6/ HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E T36, HSCD44E T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 585 below describes the starting and ending position of this segment on each transcript.

Table 585 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6 and HSCD44E_P8, since it is in the coding region for the corresponding transcript.

Segment^" cluster HSCD44E_node_54 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, H8CD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, H8CD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 586 below describes the starting and ending position of this segment on each transcript.

Table 586 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44EJP6, HSCD44E_P8 and HSCD44EJP10. This segment can also be found in the following ρrotein(s): HSCD44EJP2 and HSCD44E_P18, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_55 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 587 below describes the starting and ending position of this segment on each transcript.

Table 587 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44EJP6, HSCD44E_P8 and HSCD44EJP10. This segment can also be found in the following protein(s): HSCD44E_P2 and HSCD44E_P18, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_57 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T45 and HSCD44E_T47. Table 588 below describes the starting and ending position of this segment on each transcript.

Table 588 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P28 and HSCD44EJP29.

Segment cluster HSCD44E_node_61 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T46. Table 589 below describes the starting and ending position of this segment on each transcript.

Table 589 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSCD44Ejnode_66 according to the present hvention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T12, HSCD44E_T16 and HSCD44E_T46. Table 590 below^" describes the starting and ending position^~of this segment oh each transcript.

Table 590 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSCD44E_P10.

Segment cluster HSCD44E_node_68 according to the present invention is supported by 89 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T46, HSCD44E_T47, HSCD44E_T63 and HSCD44E_T68. Table 591 below describes the starting and ending position of this segment on each transcript.

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44E_P18, HSCD44E_P28 and HSCD44EJP29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_69 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T13 and HSCD44E T16. Table 592 below describes the starting and ending position of this segment on each transcript.

Table 592 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSCD44E_P10.

Segment cluster HSCD44E_node_73 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T13 and HSCD44E_T16. Table 593 below describes the starting and ending position of this segment on each transcript.

Table 593 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44EJP10.

Segment cluster HSCD44E_node_90 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T57. Table 594 below describes the starting and ending position of this segment on each transcript.

Table 594 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSCD44E_node_92 according to the present invention is supported by 413 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T46, HSCD44E_T47, HSCD44E_T57, HSCD44E_T63 and HSCD44E_T65. Table 595 below describes the starting and ending position of this segment on each transcript.

Table 595 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E P2, HSCD44E_P18, HSCD44EJP28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_93 according to the present invention is supported by 458 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34,

HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T46, HSCD44E_T47 and HSCD44E_T57. Table 596 below describes the starting and ending position of this segment on each transcript. Table 596 - Segment location on transcripts _ _

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, H8CD44EJP10, HSCD44E_P18, HSCD44EJP28 and HSCD44E_P29.

Segment cluster HSCD44E_node_94 according to the present invention is supported by 216 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s) : HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T46, HSCD44E_T47 and HSCD44E_T57. Table 597 below describes the starting and ending position of this segment on each transcript.

Table 597 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44E_P10, HSCD44E_P18, HSCD44E_P28 and HSCD44E_P29.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSCD44E_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T83. Table 598 below describes the starting and ending position o_f this_segment on each transcript. _

Table 598 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSCD44E_node_7 according to the present invention is supported by 160 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T38, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 599 below describes the starting and ending position of this segment on each transcript.

Table 599 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44EJP10, HSCD44E_P18 and HSCD44E_P40. This segment can also be found in the following protein(s): HSCD44E_P41, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_8 according to the present invention is supported by

168 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T38, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 600 below describes the starting and ending position of this segment on each transcript.

Table 600 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2 and HSCD44E_P18. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44E_P10, HSCD44E_P40 and HSCD44E_P41, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_10 according to the present invention is supported by

171 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, H8CD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35, HSCD44E_T38, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 601 below describes the starting and ending position of this segment on each transcript.

Table 601 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44EJP41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44E P10 and HSCD44E_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_l 1 according to the present invention is supported by 173 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35, HSCD44E_T38, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 602 below describes the starting and ending position of this segment on each transcript.

Table 602 - Segment location on transcripts

This segment can be found in both coding and non- coding legions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44E_P41. This segment can also be found in the following protein(s): HSCD44EJP4, HSCD44E_P6, HSCD44E_P8, HSCD44E_P10 and HSCD44EJP40, since it is in the coding region for the corresponding transcript. Segment cluster HSCD44E_node_12 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44EJN0, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35, HSCD44E_T38, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 603 below describes the starting and ending position of this segment on each transcript.

Table 603 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44EJP41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, H8CD44E_P8, HSCD44E_P10 and HSCD44E P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_13 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35, HSCD44E_T38, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 604 below describes the starting and ending position of this segment on each transcript.

Table 604 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44E_P41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44EJP8, HSCD44E_P10 and HSCD44E_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_17 according to the present invention is supported by 157 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T35, HSCD44E_T36, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 605 below describes the starting and ending position of this segment on each transcript.

Table 605 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44E_P41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44E P10 and HSCD44E_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_l 8 according to the present invention can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E T22, HSCD44E_T26, HSCD44E_T35, HSCD44E_T36, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 606 below describes the starting and ending position of this segment on each transcript.

Table 606 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44EJP41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44E P10 and HSCD44EJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_l 9 according to the present invention is supported by 161 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E T26, HSCD44E_T35, HSCD44E_T36, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 607 below describes the starting and ending position of this segment on each transcript.

Table 607 - Segment location on transcripts

HSCD44E T73 724 749

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44EJP18 and HSCD44EJP41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44E_P10 and HSCD44E_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_20 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T35, HSCD44E_T36,

HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 608 below describes the starting and ending position of this segment on each transcript.

Table 608 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44EJP41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44EJP8, HSCD44EJP10 and HSCD44E_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_24 according to the present invention is supported by 168 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 l«d JISCD44E_T73._Table 609_ below describes the starting and ending position of this segment on each transcript.

Table 609 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P18 and HSCD44E_P41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44EJP6, HSCD44E_P8, HSCD44EJP10 and HSCD44E P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_25 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 610 below describes the starting and ending position of this segment on each transcript.

Table 610 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HBCD44EJP18 and HSCD44E_P41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44E_P10 and HSCD44E_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_30 according to the present invention is supported by 188 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E_T73. Table 611 below describes the starting and ending position of this segment on each transcript.

Table 611 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44EJP2, HSCD44E_P18 and HSCD44E_P41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8, HSCD44EJP10 and HSCD44EJP40, since it is in the coding region for the corresponding transcript. -

Segment cluster HSCD44E_node_31 according to the present invention is supported by 187 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68, HSCD44E_T69, HSCD44E_T72 and HSCD44E T73. Table 612 below describes the starting and ending position of this segment on each transcript.

Table 612 - Segment location on transcripts

This segment can be found in both coding aid non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44EJP2, HSCD44E_P18 and HSCD44E_P41. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44EJP8, HSCD44E_P10 and HSCD44E P40, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_37 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34,

HSCD44E_T35, HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65,

HSCD44E_T68 and HSCD44E_T69. Table 613 below describes the starting and ending position of this segment on each transcript.

Table 613 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18.

Segment cluster HSCD44E_node_40 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E T1, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, H8CD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68 and HSCD44E_T69. Table 614 below describes the starting and ending position of this segment on each transcript.

Table 614 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18.

Segment cluster HSCD44E_node_42 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44EJT3, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68 and HSCD44E_T69. Table 615 below describes the starting and ending position of this segment on each transcript.

Table 615 - Segment location on transcripts

HSCD44E T69 2477 2503

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18. This segment can also be found in the following protein(s): HSCD44E_P4, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_43 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T7, HSCD44E_T10, HSCD44E T12, HSCD44E T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68 and HSCD44E T69. Table 616 below describes the starting and ending position of this segment on each transcript.

Table 616 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18. This segment can also be found in the following protein(s): HSCD44E_P4 and HSCD44E_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_47 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T63, HSCD44E_T65, HSCD44E_T68 and HSCD44E_T69. Table 617 below describes the starting and ending position of this segment on each transcript.

Table 617 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44EJP6 and HSCD44E_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_49 according to the present invention is supported by

30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16,

HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T63,

— ΗSCD44E_T65, HSCD44E_T68 and HSCD44E_T69. Table 618 below describes the starting and ending position of this segment on each transcript.

Table 618 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P2, HSCD44E_P10 and HSCD44E_P18. This segment can also be found in the following protein(s): HSCD44E_P4, HSCD44E_P6 and HSCD44E_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_58 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22; - HSCD44E_T26; — ΗSCD44E_T32 — HSCD44E_T34,

HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 619 below describes the starting and ending position of this segment on each transcript.

Table 619 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44E_P18, HSCD44E_P28 and HSCD44E P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_59 according to the present invention can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7,

HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16,

HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45,

HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 620 below describes the starting and ending position of this segment on each transcript.

Table 620 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44EJP6, HSCD44E_P8 and HSCD44E_P10. This - segment can- also be -found in-the -following- protein(s):^~HSCD44E_P2, HSCD44E_P18, HSCD44E_P28 and HSCD44E P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_64 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34,

HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 621 below describes the starting and ending position of this segment on each transcript.

Table 621 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E P2, HSCD44E_P18 and HSCD44E_P28, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_65 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T12 and HSCD44E_T16. Table 622 below describes the starting and ending position of this segment on each transcript.

Table 622 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P10.

Segment cluster HSCD44E_node_67 according to the present invention can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, H8CD44E_T8, H8CD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T46, HSCD44E_T47, HSCD44E_T63 and HSCD44E_T68. Table 623 below describes the starting and ending position of this segment on each transcript.

Table 623 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44EJP18, HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_74 according to the present invention B supported by 193 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E T6,

HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34,

HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T46, HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and

HSCD44E_T68. Table 624 below describes the starting and ending position of this segment on each transcript.

Table 624 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44EJP18, HSCD44E_P28 and HSCD44EJP29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_75 according to the present invention can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7,

HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16,

- - HSCD44E_T22, HSCD44E_T26, - HSCD44E_T32, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45,

HSCD44E_T46, HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 625 below describes the starting and ending position of this segment on each transcript.

Table 625 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44E P18, HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_77 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T26. Table 626 below describes the starting and ending position of this segment on each transcript.

Table 626 - Segment location on transcripts

This segment can be found in the following protein(s): HSCD44E_P18.

Segment cluster HSCD44E_node_79 according to the present invention can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E_T46, HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 627 below describes the starting and ending position of this segment on each transcript.

Table 627 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E__P6, HSCD44EJP8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44E_P18, HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript. Segment cluster HSCD44E_node_80 according to the present invention is supported by

206 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13,

HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34,

HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40,

HSCD44E_T45, HSCD44E_T46, HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and

HSCD44E_T68. Table 628 below describes the starting and ending position of this segment on each transcript.

Table 628 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44EJP2, HSCD44EJP18, HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_82 according to the present invention is supported by 207 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E T46, HSCD44E_T47, HSCD44E T63, HSCD44E_T65 and HSCD44E_T68. Table 629 below describes the starting and ending position of this segment on each transcript. Table^~629^'z~Segment location on transcripts ^{~ " ~}

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44E_P18, HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_83 according to the present invention can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36,^~ H^~SCD44E_T38, ^{~ ~}HSCD44E_T39, HSCD44E_T40^~ HSCD44E_T457 HSCD44E_T46, HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 630 below describes the starting and ending position of this segment on each transcript.

Table 630 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSCD44E P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44E_P18, HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_πode_84 according to the present invention can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7,

HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16,

HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45,

HSCD44E_T46, HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 631 below describes the starting and ending position of this segment on each transcript.

Table 631 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E__P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44E_P18,

HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_85 according to the present invention can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, HSCD44E_T7,

HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16,

HSCD44E_T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35,

HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45,

HSCD44E_T46, HSCD44E_T47, HSCD44E_T63, HSCD44E_T65 and HSCD44E_T68. Table 632 below describes the starting and ending position of this segment on each transcript.

Table 632 - Segment location on transcripts 2

420

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E_P2, HSCD44E_P18, HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HSCD44E_node_86 according to the present invention can be found in the following transcript(s): HSCD44E_T68. Table 633 below describes the starting and ending position of this segment on each transcript.

Table 633 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P10.

Segment cluster HSCD44E_node_91 according to the present invention is supported by 223 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCD44E_T1, HSCD44E_T3, HSCD44E_T6, H8CD44E_T7, HSCD44E_T8, HSCD44E_T10, HSCD44E_T12, HSCD44E_T13, HSCD44E_T16, HSCD44E T22, HSCD44E_T26, HSCD44E_T32, HSCD44E_T34, HSCD44E_T35, HSCD44E_T36, HSCD44E_T38, HSCD44E_T39, HSCD44E_T40, HSCD44E_T45, HSCD44E T46, HSCD44E_T47, HSCD44E__T57, HSCD44E_T63 and HSCD44E_T65. Table 634 below describes the starting and ending position of this segment on each transcript.

Table 634 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCD44E_P4, HSCD44E_P6, HSCD44E_P8 and HSCD44E_P10. This segment can also be found in the following protein(s): HSCD44E P2, HSCD44E_P18, HSCD44E_P28 and HSCD44E_P29, since it is in the coding region for he corresponding transcript.

DESCRIPTION FOR CLUSTER HSEF2

Cluster HSEF2 features 9 transcript(s) and 137 segment(s) of interest, the names for which are given in Tables 635 and 636, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 637.

Table 635 - Transcripts of interest

Transcript Name

HSEF2 T13

HSEF2 T19

HSEF2 T30

HSEF2 T38

HSEF2 T42

HSEF2 T47

HSEF2 T71

HSEF2 T82

HSEF2 T85

Table 636 - Segments of interest

Segment Name

HSEF2 node 32

HSEF2 node 41

HSEF2 node 55 HSEF2 node 65

HSEF2 node 74

HSEF2 node 111

HSEF2 node 153

HSEF2 node 0

HSEF2 node 2

HSEF2 node 3

HSEF2 node 4

HSEF2 node 5

HSEF2_ node 8

HSEF2 node 9

HSEF2 node 10

HSEF2 node 11

HSEF2 node 12

HSEF2 node 13

HSEF2 node 15

HSEF2 node 16

HSEF2 node 17

HSEF2 node 18

HSEF2 node 21

HSEF2 node 22

HSEF2 node 23

HSEF2 node 24

HSEF2 node 25

HSEF2 node 26

HSEF2 node 30

HSEF2 node 31

HSEF2 node 33

HSEF2 node 34

HSEF2 node 35

HSEF2 node 36

HSEF2 node 37

HSEF2 node 38

HSEF2 node 39

HSEF2 node 40

HSEF2 node 42

HSEF2 node 43

HSEF2 node 44

HSEF2 node 45

HSEF2 node 46

HSEF2 node 47

HSEF2 node 48

HSEF2 node 49

HSEF2 node 51 HSEF2 node 52

HSEF2 node 53

HSEF2 node 54

HSEF2 node 56

HSEF2 node 57

HSEF2 node 58

HSEF2 node 59

HSEF2 node 60

HSEF2 node 61

HSEF2 node 62

HSEF2 node 63

HSEF2 node 64

HSEF2 node 67

HSEF2 node 68

HSEF2 node 69

HSEF2 node 70

HSEF2 node 71

HSEF2 node 72

HSEF2 node 73

HSEF2 node 77

HSEF2 node 78

HSEF2 node 79

HSEF2 node 80

HSEE2 node 81

HSEF2 node 82

HSEF2 node 83

HSEF2 node 84

HSEF2 node 85

HSEF2 node 86

HSEF2 node 87

HSEF2 node 88

HSEF2 node 89

HSEF2 node 90

HSEF2 node 91

HSEF2 node 92

HSEF2 node 96

HSEF2 node 97

HSEF2 node 98

HSEF2 node 99

HSEF2 node 100

HSEF2 node 101

HSEF2 node 102

HSEF2 node 103

HSEF2 node 104 HSEF2 node 105

HSEF2 node 106

HSEF2 node 107

HSEF2 node 108

HSEF2 node 109

HSEF2 node 110

HSEF2 node 113

HSEF2 node 114

HSEF2 node 115

HSEF2 node 116

HSEF2 node 117

HSEF2 node 118

HSEF2 node 119

HSEF2 node 120

HSEF2 node 121

HSEF2 node 122

HSEF2 node 123

HSEF2 node 124

HSEF2 node 125

HSEF2 node 126

HSEF2 node 127

HSEF2 node 128

HSEF2 node 129

HSEF2 node J 30

HSEF2 node 131

HSEF2 node 132

HSEF2 node 133

HSEF2 node 134

HSEF2 node 135

HSEF2 node 136

HSEF2 node 137

HSEF2 node 138

HSEF2 node 139

HSEF2 node 140

HSEF2 node 141

HSEF2 node 142

HSEF2 node 143

HSEF2 node 144

HSEF2 node 145

HSEF2 node 146

HSEF2 node 147

HSEF2 node 148

HSEF2 node 149

HSEF2 node 150 HSEF2 node 151

HSEF2 node 152

Table 637 - Proteins of interest

These sequences are variants of the known protein Elongation factor 2 (SwissProt accession identifier EF2JHUMAN; known also according to the synonyms EF-2), referred to herein as the previously known protein.

Protein Elongation factor 2 is known or believed to have the following function(s): This protein promotes the GTP -dependent translocation of the nascent protein chain from the A- site to the P-site of the ribosome. The sequence for protein Elongation factor 2 is given at the end of the application, as "Elongation factor 2 amino acid sequence". Protein Elongation factor 2 localization is believed to be Cytoplasmic.

Cluster HSEF2 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of figure 19 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 19 and Table 638. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: prostate cancer. Table 638 - Normal tissue distribution

Table 639 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSEF2 features 137 segment(s), which were listed in Table 636 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSEF2_node_32 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T19 and HSEF2_T30. Table 640 below describes the starting and ending position of this segment on each transcript. ^{~ ~ ~~ ~}

Table 640 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7 and HSEF2_P15.

Segment cluster HSEF2_node_41 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T30 and HSEF2_T38. Table 641 below describes the starting and ending position of this segment on each transcript.

Table 641 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P15, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_55 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T38, HSEF2_T82 and HSEF2_T85. Table 642 below describes the starting and ending position of this segment on each transcript.

Table 642 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_65 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T85. Table 643 below describes the starting and ending position of this segment on each transcript.

Table 643 - Segment location on transcripts W 2

430

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2_P2.

Segment cluster HSEF2_node_74 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T71 and HSEF2_T82. Table 644 below describes the starting and ending position of this segment on each transcript.

Table 644 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as -follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2 P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_l 11 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T42 and HSEF2_T47. Table 645 below describes the starting and ending position of this segment on each transcript.

Table 645 - Segment location on transcripts

This segment can be found in both coding and non-coding legions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P6. This segment can also be found in the following protein(s): HSEF2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_153 according to the present invention is supported by 192 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 646 below describes the starting and ending position of this segment on each transcript.

Table 646 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2J^>22.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSEF2_node_0 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 647 below describes the starting and ending position of this segment on each transcript.

Table 647 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2JP22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_2 according to the present invention is supported by 143 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38,

HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 648 below describes the starting and ending position of this segment on each transcript.

Table 648 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2JP6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_3 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 649 below describes the starting and ending position of this segment on each transcript.

Table 649 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_4 according to the present invention is supported by 166 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38,

HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 650 below describes the starting and ending position of this segment on each transcript.

Table 650 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_5 according to the present invention is supported by 187 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2 T19, HSEF2_T30, HSEF2_T38,

HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 651 below describes the starting and ending position of this segment on each transcript.

Table 651 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_8 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 652 below describes the starting and ending position of this segment on each transcript.

Table 652 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2JP26, HSEF2JP6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_9 according to the present invention is supported by 197 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 653 below describes the starting and ending position of this segment on each transcript.

Table 653 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2 P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_10 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 654 below describes the starting and ending position of this segment on each transcript.

Table 654 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2__P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_l l according to the present invention is supported by 195 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 655 below describes the starting and ending position of this segment on each transcript.

Table 655 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_12 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and H8EF2_T85. Table 656 below describes the starting and ending position of this segment on each transcript.

Table 656 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2JP2, HSEF2_P26, HSEF2JP6 and HSEF2JP54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_13 according to the present invention is supported by 196 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s):^~HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38,

HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 657 below describes the starting and ending position of this segment on each transcript.

Table 657 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_15 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 658 below describes the starting and ending position of this segment on each transcript.

Table 658 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2JP54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_16 according to the present invention is supported by 207 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 659 below describes the starting and ending position of this segment on each transcript. Table 659 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_17 according to the present invention is supported by 216 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 660 below describes the starting and ending position of this segment on each transcript.

Table 660 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2JP6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_18 according to the present invention is supported by 232 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 661 below describes the starting and ending position of this segment on each transcript.

Table 661 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2JP2, HSEF2_P26, HSEF2_P6 and HSEF2JP54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_21 according to the present invention is supported by 230 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 662 below describes the starting and ending position of this segment on each transcript.

Table 662 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2JP15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_22 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2 T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 663 below describes the starting and ending position of this segment on each transcript.

Table 663 - Segment location on transcripts

HSEF2 T85 780 798

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_23 according to the present invention can be found in the following transcript(s): HSEF2_T13, H8EF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 664 below describes the starting and ending position of this segment on each transcript.

Table 664 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_24 according to the present invention is supported by 217 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 665 below describes the starting and ending position of this segment on each transcript.

Table 665 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2JP6 and HSEF2 P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_25 according to the present invention is supported by 225 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 666 below describes the starting and ending position of this segment on each transcript.

Table 666 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2JP22. This segment can also be found in the following protein(s): HSEF2JP2, HSEF2JP26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_26 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 667 below describes the starting and ending position of this segment on each transcript.

Table 667 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2JP26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_30 according to the present invention is supported by 253 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 668 below describes the starting and ending position of this segment on each transcript.

Table 668 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_31 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 669 below describes the starting and ending position of this segment on each transcript.

Table 669 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_33 according to the present invention is supported by 222 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 670 below describes the starting and ending position of this segment on each transcript.

Table 670 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_34 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 671 below descπbes the starting and ending position of this segment on each transcript.

Table 671 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2JP2, HSEF2_P7, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_35 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 672 below describes the starting and ending position of this segment on each transcript.

Table 672 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_36 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 673 below describes the starting and ending position of this segment on each transcript.

Table 673 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_37 according to the present invention can be found in the following transcπpt(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 674 below describes the starting and ending position of this segment on each transcript.

Table 674 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the

__following protein(s):_HSEF2_P15_and HSEF2_P22. This segment_can_ also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_38 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 675 below describes the starting and ending position of this segment on each transcript.

Table 675 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_39 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, H8EF2_T38, H8EF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 676 below describes the starting and ending position of this segment on each transcript.

Table 676 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P15 and HSEF2_P22. This segment can also be found in the following protein(s): HSEF2JP2, HSEF2_P7, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_40 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 677 below describes the starting and ending position of this segment on each transcript.

Table 677 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following j)rotein(s): HSEF2_P15 and HSEF2_P22._This segment can also be .found injhe following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_42 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 678 below describes the starting and ending position of this segment on each transcript.

Table 678 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_43 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 679 below describes the starting and ending position of this segment on each transcript.

Table 679 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node__44 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 680 below describes the starting and ending position of this segment on each transcript.

Table 680 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the_ following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_45 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 681 below describes the starting and ending position of this segment on each transcript.

Table 681 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2JP7, HSEF2_P15, HSEF2_P26, HSEF2JP6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_46 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 682 below describes the starting and ending position of this segment on each transcript.

Table 682 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s):

HSEF2_P2, HSEF2_P7, HSEF2_P15, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_47 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 683 below describes the starting and ending position of this segment on each transcript.

Table 683 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2 P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_48 according to the present invention is supported by 205 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38,

HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 684 below describes the starting and ending position of this segment on each transcript.

Table 684 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2JP2, HSEF2JP7, HSEF2_P15, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_49 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 685 below describes the starting and ending position of this segment on each transcript.

Table 685 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of ■transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15, HSEF2_P26, HSEF2_P6 and HSEF2JP54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_51 according to the present invention is supported by 199 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 686 below describes the starting and ending position of this segment on each transcript.

Table 686 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in_a non-coding region of transcript(s) that are related to the following protein(s): HSEF2JP22. This segment can also be found in the following protein(s):

HSEF2_P2, HSEF2JP7, HSEF2_P15, HSEF2_P26, HSEF2JP6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_52 according to the present invention is supported by 217 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38,

HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 687 below describes the starting and ending position of this segment on each transcript.

Table 687 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2JP15, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_53 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2 _T71, HSEF2_T82 and HSEF2_T85. Table 688 below describes the starting and ending position of this segment on each transcript.

Table 688 - Segment location on transcripts _ __

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P22. This segment can also be found in the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_54 according to the present invention is supported by 201 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 689 below describes the starting and ending position of this segment on each transcript.

Table 689 - Segment location on transcripts

This segment can be found in_. both coding and non-coding regions of transcript(s)_as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2 P22. This segment can also be found in the following protein(s):

HSEF2_P2, HSEF2_P7, HSEF2_P15, HSEF2_P26, HSEF2_JP6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_56 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 690 below describes the starting and ending position of this segment on each transcript.

Table 690 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2 P15, HSEF2_P22, HSEF2JP26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_57 according to the present invention is supported by 227 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 691 below describes the starting and ending position of this segment on each transcript.

Table 691 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_58 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 692 below describes the starting and ending position of this segment on each transcript.

Table 692 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_59 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 693 below describes the starting and ending position of this segment on each transcript. Table 693 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2J^>15, HSEF2JP22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_60 according to the present invention is supported by 235 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 694 below describes the starting and ending position of this segment on each transcript.

Table 694 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2JP6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_61 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 695 below describes the starting and ending position of this segment on each transcript.

Table 695 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_62 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 696 below describes the starting and ending position of this segment on each transcript. Table 696 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2 P2. This segment can also be found in the following protein(s): HSEF2J^>7, HSEF2JP15, HSEF2_P22, HSEF2_P26, HSEF2JP6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_63 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, H8EF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 697 below describes the starting and ending position of this segment on each transcript.

Table 697 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_64 according to the present invention is supported by 258 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71, HSEF2_T82 and HSEF2_T85. Table 698 below describes the starting and ending position of this segment on each transcript.

Table 698 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): HSEF2JP2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2JP15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_67 according to the present invention is supported by 234 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71 and HSEF2_T82. Table 699 below describes the starting and ending position of this segment on each transcript.

Table 699 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_68 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71 and HSEF2_T82. Table 700 below describes the starting and ending position of this segment on each transcript.

Table 700 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2JP7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_69 according to the present invention is supported by 235 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71 and HSEF2_T82. Table 701 below describes the starting and ending position of this segment on each transcript.

Table 701 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2JP2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_70 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71 and HSEF2_T82. Table 702 below describes the starting and ending position of this segment on each transcript.

Table 702 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2JP15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_71 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71 and HSEF2_T82. Table 703 below describes the starting and ending position of this segment on each transcript.

Table 703 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2JP26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_72 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71 and HSEF2_T82. Table 704 below describes the starting and ending position of this segment on each transcript.

Table 704 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26, HSEF2_P6 and HSEF2_P54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_73 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42, HSEF2_T47, HSEF2_T71 and HSEF2_T82. Table 705 below describes the starting and ending position of this segment on each transcript.

Table 705 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2JP26, HSEF2_P6 and HSEF2JP54, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_77 according to the present invention is supported by 256 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 706 below describes the starting and ending position of this segment on each transcript.

Table 706 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7_> HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_78 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 707 below describes the starting and ending position of this segment on each transcript.

Table 707 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2JP15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_79 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 708 below describes the starting and ending position of this segment on each transcript. Table 708 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2JP15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_80 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 709 below describes the starting and ending position of this segment on each transcript.

Table 709 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_81 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 710 below describes the starting and ending position of this segment on each transcript. Table 710 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2J^»22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_82 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 711 below describes the starting and ending position of this segment on each transcript.

Table 711 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_83 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 712 below describes the starting and ending position of this segment on each transcript. Table 712 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s):

HSEF2_P7, HSEF2_P15, H8EF2_P22, HSEF2_P26 ard HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_84 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 713 below describes the starting and ending position of this segment on each transcript.

Table 713 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_85 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 714 below describes the starting and ending position of this segment on each transcript.

Table 714 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2JP2. This segment can also be found in the following protein(s):

HSEF2JP7, HSEF2JP15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_86 according to the present invention is supported by 245 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38,

HSEF2_T42 and HSEF2_T47. Table 715 below describes the starting and ending position of this segment on each transcript.

Table 715 - Segment location on transcripts

HSEF2 T47 1948 1979

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2JP6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_87 according to the present invention is supported by 250 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 716 below describes the starting and ending position of this segment on each transcript.

Table 716 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_88 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 717 below describes the starting and ending position of this segment on each transcript. Table 717 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s):

HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2J^>26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_89 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 718 below describes the starting and ending position of this segment on each transcript.

Table 718 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2JP22, HSEF2_P26 and HSEF2JP6, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_90 according to the present invention is supported by 245 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2 T47. Table 719 below describes the starting and ending position of this segment on each transcript.

Table 719 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the

_ following protein(s): HSEF2_P2. This segment can also be found in the following protein(s):

HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2__node_91 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 720 below describes the starting and ending position of this segment on each transcript.

Table 720 - Segment location on transcripts

HSEF2 T47 2070 2090

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_92 according to the present invention is supported by 240 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 721 below describes the starting and ending position of this segment on each transcript.

Table 721 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2JP2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_96 according to the present invention is supported by 246 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2JI38, HSEF2_T42 and HSEF2_T47. Table 722 below describes the starting and ending position of this segment on each transcript.

Table 722 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): H8EF2JP7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_97 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 723 below describes the starting and ending position of this segment on each transcript. Table 723 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_98 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 724 below describes the starting and ending position of this segment on each transcript.

Table 724 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2 P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_99 according to the present invention is supported by 215 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19₅ HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 725 below describes the starting and ending position of this segment on each transcript.

Table 725 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_100 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 726 below describes the starting and ending position of this segment on each transcript.

Table 726 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2JP7, HSEF2JP15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_101 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 727 below describes the starting and ending position of this segment on each transcript.

Table 727 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_102 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T47. Table 728 below describes the starting and ending position of this segment on each transcript.

Table 728 - Segment location on transcripts

This segment can be found in the following protein(s): HSEF2_P6.

Segment cluster HSEF2_node_103 according to the present invention is supported by 236 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 729 below describes the starting and ending position of this segment on each transcript.

Table 729 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2JP7, HSEF2_P15, HSEF2_P22, HSEF2_P26 and HSEF2J^>6, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_104 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 730 below describes the starting and ending position of this segment on each transcript.

Table 730 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2 and HSEF2_P6. This segment can also be found in the following protem(s): HSEF2_P7, HSEF2_P15, HSEF2_P22 and HSEF2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_105 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 731 below describes the starting and ending position of this segment on each transcript.

Table 731 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2 and HSEF2__P6. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22 and HSEF2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_106 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 732 below describes the starting and ending position of this segment on each transcript. Table 732 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2 and HSEF2_P6. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22 and HSEF2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_107 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 733 below describes the starting and ending position of this segment on each transcript.

Table 733 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2 and HSEF2_P6. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22 and HSEF2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_108 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 734 below describes the starting and ending position of this segment on each transcript. Table 734 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2 and HSEF2_P6. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22 and HSEF2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_109 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and JHSJiF2_T47₁_TableJ735 below_ describes the_ starting and ending position of this segment_on_ each transcript.

Table 735 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2JP2 and HSEF2_P6. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22 and HSEF2_P26, since it is in the coding region for the corresponding transcript. Segment cluster HSEF2_node_l 10 according to the present invention is supported by 258 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30, HSEF2_T38, HSEF2_T42 and HSEF2_T47. Table 736 below describes the starting and ending position of this segment on each transcript.

Table 736 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2_and HSEF2_P6. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15, HSEF2_P22 and HSEF2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_l 13 according to the present invention is supported by 262 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 737 below describes the starting and ending position of this segment on each transcript.

Table 737 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s):

HSEF2_P7, HSEF2_P15 and HSEF2_P22, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_l 14 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 738 below describes the starting and ending position of this segment on each transcript. Table 738 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the fillowing protein(s): HSEF2_P7, HSEF2_P15 and HSEF2JP22, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_ 115 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 739 below describes the starting and ending position of this segment on each transcript.

Table 739 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2JP15 and HSEF2_P22, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_l 16 according to the present invention is supported by 241 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 740 below describes the starting and ending position of this segment on each transcript.

Table 740 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s):

HSEF2_P7, HSEF2_P15 and HSEF2_P22, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_117 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 741 below describes the starting and ending position of this segment on each transcript.

Table 741 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2__P15 and HSEF2_P22, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_l 18 according to the present invention can be found in the following transcripts): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 742 below describes the starting and ending position of this segment on each transcript.

Table 742 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s):

HSEF2_P7, HSEF2_P15 and HSEF2_P22, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_119 according to the present invention is supported by 226 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 743 below describes the starting and ending position of this segment on each transcript.

Table 743 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_120 according to the present invention is supported by 254 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 744 below describes the starting and ending position of this segment on each transcript.

Table 744 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2 P2. This segment can also be found in the following protein(s): HSEF2_P7, HSEF2_P15 and HSEF2_P22, since it is in the coding region for the corresponding transcript.

Segment cluster HSEF2_node_121 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 745 below describes the starting and ending position of this segment on each transcript.

Table 745 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_122 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 746 below describes the starting and ending position of this segment on each transcript.

Table 746 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_123 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 747 below describes the starting and ending position of this segment on each transcript.

Table 747 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2JP15 and HSEF2_P22.

Segment cluster HSEF2_node_124 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 748 below describes the starting and ending position of this segment on each transcript.

Table 748 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2__P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_125 according to the present invention can be found in the ^" following traήscφt(s): ^"HSEF2_T13, HSEF2_T19,^~HSEF2_T30 and HSEF2_T38. Table 749 below describes the starting and ending position of this segment on each transcript. Table 749 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_126 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 750 below describes the starting and ending position of this segment on each transcript. Table 750 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_ P15 and HSEF2_P22.

Segment cluster HSEF2_node_127 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 751 below describes the starting and ending position of this segment on each transcript.

Table 751 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_128 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 752 below describes the starting and ending position of this segment on each transcript.

Table 752 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2JP7, HSEF2_P15 and HSEF2JP22.

Segment cluster HSEF2_node_129 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 753 below describes the starting and ending position of this segment on each transcript.

Table 753 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2J^>15 and HSEF2_P22.

Segment cluster HSEF2_node_130 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 754 below describes the starting and ending position of this segment on each transcript.

Table 754 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_131 according to the present invention is supported by 320 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 755 below describes the starting and ending position of this segment on each transcript.

Table 755 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_132 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, H8EF2_T30 and HSEF2_T38. Table 756 below describes the starting and ending position of this segment on each transcript.

Table 756 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_133 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 757 below describes the starting and ending position of this segment on each transcript.

Table 757 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_134 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 758 below describes the starting and ending position of this segment on each transcript.

Table 758 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_135 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 759 below describes the starting and ending position of this segment on each transcript.

Table 759 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2JP7, HSEF2_P15 and HSEF2_P22. Segment cluster HSEF2_node_136 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 760 below describes the starting and ending position of this segment on each transcript.

Table 760 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_137 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 761 below describes the starting and ending position of this segment on each transcript.

Table 761 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2JP15 and HSEF2_P22.

Segment cluster HSEF2_node_138 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 762 below describes the starting and ending position of this segment on each transcript. Table 762 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_139 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 763 below describes the starting and ending position of this segment on each transcript.

Table 763 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_140 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 764 below describes the starting and ending position of this segment on each transcript.

Table 764 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2JP2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_141 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 765 below describes the starting and ending position of this segment on each transcript.

Table 765 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2JP2, HSEF2_P7, HSEF2_P 15 and HSEF2_P22.

Segment cluster HSEF2_node_142 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 766 below describes the starting and ending position of this segment on each transcript. Table 766 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_143 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 767 below describes the starting and ending position of this segment on each transcript. Table 767 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_144 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 768 below describes the starting and ending position of this segment on each transcript.

Table 768 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_145 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 769 below describes the starting and ending position of this segment on each transcript.

Table 769 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2JP2, HSEF2JP7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_146 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 770 below describes the starting and ending position of this segment on each transcript.

Table 770 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_147 according to the present invention is supported by 272 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 771 below describes the starting and ending position of this segment on each transcript.

Table 771 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2JP7, HSEF2_P15 and HSEF2_P22. Segment cluster HSEF2_node_148 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 772 below describes the starting and ending position of this segment on each transcript.

Table 772 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2JP15 and HSEF2_P22.

Segment cluster HSEF2_node_149 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 773 below describes the starting and ending position of this segment on each transcript.

Table 773 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P 15 and HSEF2_P22.

Segment cluster HSEF2_node_150 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 774 below describes the starting and ending position of this segment on each transcript. Table 774 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_151 according to the present invention can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 775 below describes the starting and ending position of this segment on each transcript.

Table 775 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2_P2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

Segment cluster HSEF2_node_152 according to the present invention is supported by 226 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSEF2_T13, HSEF2_T19, HSEF2_T30 and HSEF2_T38. Table 776 below describes the starting and ending position of this segment on each transcript.

Table 776 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSEF2J^»2, HSEF2_P7, HSEF2_P15 and HSEF2_P22.

DESCRIPTION FOR CLUSTER HSU03911

Cluster HSU03911 features 6 transcript(s) and 33 segment(s) of interest, the names for which are given in Tables 777 and 778, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 779.

Table 777 - Transcripts of interest

Transcript Name

HSU03911 Tl

HSU03911 T3

HSU03911 TIl

HSU03911 T12

HSU03911 T17

HSU03911 T18

Table 778 - Segments of interest

Segment Name <

HSU03911 node 0

HSU03911 node 14

HSU03911 node 18

HSU03911 node 20

HSU03911 node 22

HSU03911 node 24

HSU03911 node 28

HSU03911 node 32

HSU03911 node 33

HSU03911 node 35

HSU03911. node 41

HSU03911 node 43

HSU03911 node 45

HSU03911 node 48

HSU03911 node 51

Table 779 - Proteins of interest

These sequences are variants of the known protein DNA mismatch repair protein Msh2 (SwissProt accession identifier MSH2_HUMAN), referred to herein as the previously known protein.

Protein DNA mismatch repair protein Msh2 is known or believed to have the following function(s): Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair. The sequence for protein DNA mismatch repair protein Msh2 is given at the end of the application, as "DNA mismatch repair protein Msh2 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 780.

Table 780 - Amino acid mutations for Known Protein

Protein DNA mismatch repair protein Msh2 localization is believed to be Nuclear (Potential).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: mismatch repair; post-replication repair, which are annotation(s) related to Biological Process; DNA binding; damaged DNA binding; ATP binding, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to

_Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nkn.nih.gov/projects/LocusLink/>.

Cluster HSU03911 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 20 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 20 and Table 781. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues. 20

Table 781 - Normal tissue distribution

Table 782 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSU03911 features 33 segment(s), which were listed in Table

778 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSU0391 l_node_0 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_Tl, HSU03911_T3 and HSU03911_Tll. Table 783 below describes the starting and ending position of this segment on each transcript.

Table 783 ~ Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PI l.

Segment cluster HSU03911_node_14 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1, HSU03911_T3 and HSUO3911_T11. Table 784 below describes the starting and ending position of this segment on each transcript.

Table 784 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911JP2, HSU03911JP4 and HSU0391 IJPl 1.

Segment cluster HSU03911_node_18 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911JN, HSU03911_T3 and HSUO3911_T11. Table 785 below describes the starting and ending position of this segment on each transcript.

Table 785 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911JP2, HSU03911_P4 and HSU03911 PIl.

Segment cluster HSU03911_node_20 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T1, HSU03911_T3 and HSUO3911_T11. Table 786 below describes the starting and ending position of this segment on each transcript.

Table 786 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911_Pl l.

Segment cluster HSU03911_node_22 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1, HSU03911_T3 and HSU0391 I_Tl L Table 787 below descπbes the starting and ending position of this segment on each transcript.

Table 787 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PI l.

Segment cluster HSU03911_node_24 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1, HSU03911_T3 and HSUO3911_T11. Table 788 below describes the starting and ending position of this segment on each transcript.

Table 788 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911JP2, HSU03911_P4 and HSU03911 PIl.

Segment cluster HSU0391 l_node_28 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T11. Table 789 below describes the starting and ending position of this segment on each transcript.

Table 789 - Segment location on transcripts

This segment can be found in the following protein(s): HSU0391 IJPl 1.

Segment cluster HSU0391 l_node_32 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T12 and HSU03911_T17. Table 790 below describes the starting and ending position of this segment on each transcript.

Table 790 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSU03911_P12.

Segment cluster HSU03911_node_33 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1, HSU03911_T3, HSU03911_T12 and HSU03911_T17. Table 791 below describes the starting and ending position of this segment on each transcript.

Table 791 - Segment location on transcripts

HSU0391 1 T17 385 508

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911_P12.

Segment cluster HSU03911_node_35 according to the present invention is supported by

42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_Tl, HSU03911_T3, HSU03911_T12 and HSU03911_T17. Table 792 below describes the starting and ending position of this segment on each transcript. Table 792 - Segment location on transcripts

This segment can be fiund in the following protein(s): HSU03911_P2, HSU03911JP4 and HSU03911 P12.

Segment cluster HSU03911_node_41 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_Tl, HSU03911_T3 and HSU03911_T12. Table 793 below describes the starting and ending position of this segment on each transcript.

Table 793 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911JP2, HSU03911_P4 and HSU03911 P12. Segment cluster HSU03911_node_43 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1, HSU03911_T3 and HSU03911_T12. Table 794 below describes the starting and ending position of this segment on each transcript.

Table 794 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911_P12.

Segment cluster HSU03911_node_45 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1, HSU03911_T3 and HSU03911_T12. Table 795 below describes the starting and ending position of this segment on each transcript.

Table 795 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911JP4 and HSU03911 P12.

Segment cluster HSU0391 l_node_48 according to the present invention is supported by

88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T1, HSU03911_T3 and HSU03911_T12. Table 796 below describes the starting and ending position of this segment on each transcript. Table 796 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911JP2, HSU03911_P4 and HSU03911 P12.

Segment cluster HSU03911_node_51 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T12. Table 797 below describes the starting and ending position of this segment on each transcript.

Table 797 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P12.

Segment cluster HSU0391 l_node_58 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T3 and HSU03911_T18. Table 798 below describes the starting and ending position of this segment on each transcript.

Table 798 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P4. Segment cluster HSU0391 l_node_60 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1. Table 799 below describes the starting and ending position of this segment on each transcript.

Table 799 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSU0391 l_node_l according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript© : HSU03911_T1, HSU03911_T3 and HSU0391 IJN 1. Table 800 below describes the starting and ending position of this segment on each transcript.

Table 800 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PI l.

Segment cluster HSU03911_node_2 according to the present invention can be found in the following transcript(s): HSU03911_T1, HSU03911_T3 and HSU03911JN 1. Table 801 below describes the starting and ending position of this segment on each transcript. Table 801 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911_Pl l.

Segment cluster HSU0391 l_node_3 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T1 , HSU03911_T3 and HSUO3911_T11. Table 802 below describes the starting and ending position of this segment on each transcript.

Table 802 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PIl.

Segment cluster HSU0391 l_node_5 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T1, HSU03911_T3 and HSUO3911_T11. Table 803 below describes the starting and ending position of this segment on each transcript.

Table 803 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911JP2, HSU03911_P4 and HSU03911_Pl l.

Segment cluster HSU0391 l_node_6 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T1, HSU03911_T3 and HSU03911_T11. Table 804 below describes the starting and ending position of this segment on each transcript.

Table 804 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PIl.

Segment cluster HSU0391 l_node_7 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T1, HSU03911_T3 and HSUO3911_T11. Table 805 below describes the starting and ending position of this segment on each transcript.

Table 805 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PIl. Segment cluster HSU03911_node_8 according to the present invention can be found in the following transcript(s): HSU03911_T1, HSU03911_T3 and HSUO3911_T11. Table 806 below describes the starting and ending position of this segment on each transcript.

Table 806 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911JP2, HSU03911_P4 and HSU03911 PI l.

Segment cluster HSU03911_node_10 according to the present invention can be found in the following transcript(s): HSUO3911_T1, HSU03911_T3 and HSU03911_T11. Table 807 below describes the starting and ending position of this segment on each transcript.

Table 807 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PIl.

Segment cluster HSU03911_node_ll according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1, HSU03911_T3 and HSUO3911_T11. Table 808 below describes the starting and ending position of this segment on each transcript.

Table 808 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PI l .

Segment cluster HSU03911_node_12 according to the present invention can be found in the following transcript(s): HSU03911_T1, HSU03911_T3 and HSUO3911_T11. Table 809 below describes the starting and ending position of this segment on each transcript.

Table 809 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911JP4 and HSU03911 PIl.

Segment cluster HSU03911_node_13 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_Tl, HSU03911_T3 and HSUO3911_T11. Table 810 below describes the starting and ending position of this segment on each transcript.

Table 810 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911 PIl. Segment cluster HSU03911_node_26 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1, HSUO3911_T3 and HSU03911_T11. Table 811 below describes the starting and ending position of this segment on each transcript.

Table 811 - Segment location on transcripts

This segment can be found in the following ρrotein(s): HSU03911JP2, HSU03911_P4 and HSU0391 IJPl 1.

Segment cluster HSU0391 l_node_36 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T17. Table 812 below describes the starting and ending position of this segment on each transcript.

Table 812 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSU03911_node_39 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_Tl, HSU03911_T3 and HSU03911_T12. Table 813 below describes the starting and ending position of this segment on each transcript.

Table 813 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2, HSU03911_P4 and HSU03911_P12.

Segment cluster HSU0391 l_node_53 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUO3911_T1 and HSU03911_T3. Table 814 below describes the starting and ending position of this segment on each transcript.

Table 814 - Segment location on transcripts

This segment can be found in the following protein(s): HSU03911_P2 and HSU03911 P4.

Segment cluster HSU0391 l_node_56 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSU03911_T18. Table 815 below describes the starting and ending position of this segment on each transcript.

Table 815 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER HUMCAlXIA Cluster HUMCAlXlA features 1 transcript(s) and 26 segment(s) of interest, the names for which are given in Tables 816 and 817, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 818.

Table 816 - Transcripts of interest

Transcript Name

HUMCAlXIA T18

Table 817 - Segments of interest

Segment Name

HUMCAlXIA node 0

HUMCAlXIA node 2

HUMCAlXIA node 4

HUMCAlXIA node 6

HUMCAlXIA node 8

HUMCAlXIA node 18

HUMCAlXIA node 55

HUMCAlXIA node 11

HUMCAlXIA node 15

HUMCAlXIA node 19

HUMCAlXIA node 21

HUMCAlXIA node 23

HUMCAlXIA node 25

HUMCAlXIA node 27

HUMCAlXIA node 29

HUMCAlXIA node 31

HUMCAlXIA node 33

HUMCAlXIA node 35

HUMCAlXIA. node 37

HUMCAlXIA node 39

HUMCAlXIA node 41

HUMCAlXIA node 43

HUMCAlXIA node 45

HUMCAlXIA node 47

HUMCAlXIA node 49

HUMCAlXIA node 51

Table 818 - Proteins of interest

These sequences are variants of the known protein Collagen alpha 1 (SwissProt accession identifier CA1BJHUMAN; known also according to the synonyms XI), referred to herein as the previously known protein.

Protein Collagen alpha 1 is known or believed to have the following function(s): May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. The sequence for protein Collagen alpha 1 is given at the end of the application, as "Collagen alpha 1 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 819.

Table 819 -Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cartilage condensation; vision; hearing; cell-cell adhesion; extracellular matrix organization and biogenesis, which are annotation(s) related to Biological Process; extracellular matrix structural protein; extracellular matrix protein, adhesive, which are annotation(s) related to Molecular Function; and extracellular matrix; collagen; collagen type XI, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HUMCAlXIA can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 21 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 21 and Table 820. This cluster is overexpressed (at least at a minimum le-vel) in the following pathological conditions: bone malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues and lung malignant tumors.

Table 820 - Normal tissue distribution

Table 821 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMCAlXIA features 26 segment(s), which were listed in Table

817 above and ion.which_the sequence(s) are given at the end of the .application These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMCA lXIA_node_0 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 822 below describes the starting and ending position of this segment on each transcript.

Table 822 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15. Segment cluster HUMCA lXIA_node_2 according to the present invention is supported by 9 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMCAl XIA_T18. Table 823 below describes the starting and ending position of this segment on each transcript.

Table 823 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Segment cluster HUMCAl XI A node_4 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCAl XIA_Tl 8. Table 824 below describes the starting and ending position of this segment on each transcript.

Table 824 ~ Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 825.

Table 825 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMCA1XIA_P15. Segment cluster HUMCAl XI A_node_6 according to the present Invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMC Al XIA_Tl 8. Table 826 below describes the starting and ending position of this segment on each transcript.

Table 826 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 827.

Table 827 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Segment cluster HUMCA lXIA_node_8 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 828 below describes the starting and ending position of this segment on each transcript.

Table 828 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIAJP15. Segment cluster HUMCAlXIA_node_18 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCAl XIA_Tl 8. Table 829 below describes the starting and ending position of this segment on each transcript.

Table 829 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIAJP15.

Segment cluster HUMCAlXIA_node_55 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMC AlXIA_Tl 8. Table 830 below describes the starting and ending position of this segment on each transcript.

Table 830 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 831.

Table 831 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMCA1XIAJP15. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMCA lXIA_node_l 1 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCAl XIA_T 18. Table 832 below describes the starting and ending position of this segment on each transcript.

Table 832 - Segment location on transcripts

This segment can be found in the following protein(s): HUMC A IXI A PI 5.

Segment cluster HUMCAlXIA_node_15 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 833 below describes the starting and ending position of this segment on each transcript.

Table 833 ~ Segment location on transcripts

This segment can be found in the following protein(s): HUMC AlXIAJPl 5.

Segment cluster HUMCAlXIA_node_19 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 834 below describes the starting and ending position of this segment on each transcript. Table 834 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Segment cluster HUMCAl XI A_node_21 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA T18. Table 835 below describes the starting and ending position of this segment on each transcript.

Table 835 - Segment location on transcripts

This segment can be found in the following protein(s): HUMC AlXIA-Pl 5.

Segment cluster HUMCAlXIA_node_23 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCAl XIA Tl 8. Table 836 below describes the starting and ending position of this segment on each transcript.

Table 836 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1X3A_P15.

Segment cluster HUMCA lXIA_node_25 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XLA_T18. Table 837 below describes the starting and ending position of this segment on each transcript.

Table 837 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA 1XIA_P 15.

Segment cluster HUMCAlXIA__node_27 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 838 below describes the starting and ending position of this segment on each transcript.

Table 838 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA 1XIA_P 15.

Segment cluster HUMCAlXIA_node_29 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 839 below describes the starting and ending position of this segment on each transcript.

Table 839 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Segment cluster HUMCAlXIA_node_31 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 840 below describes the starting and ending position of this segment on each transcript.

Table 840 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Segment cluster HUMCA lXIA_node_33 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA IXIA_Tl 8. Table 841 below describes the starting and ending position of this segment on each transcript.

Table 841 - Segment location on transcripts

This segment can be found in the following protein(s): HUMC AlXIA Pl 5.

Segment cluster HUMCAlXIA_node_35 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMC AlXIA_Tl 8. Table 842 below describes the starting and ending position of this segment on each transcript.

Table 842 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIAJP15.

Segment cluster HUMCAlXIA_node_37 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 843 below describes the starting and ending position of this segment on each transcript.

Table 843 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA 1XIA_P 15.

Segment cluster HUMCAlXIA_node_39 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): HUMCAl XIA_Tl 8. Table 844 below describes the starting and ending position of this segment on each transcript.

Table 844 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Segment cluster HUMCAlXIA_node_41 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCAl XIA_T 18. Table 845 below describes the starting and ending position of this segment on each transcript.

Table 845 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCAl XIA_P15.

Segment cluster HUMCAlXIA_node_43 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 846 below describes the starting and ending position of this segment on each transcript.

Table 846 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA IXIAJPl 5.

Segment cluster HUMCAlXIA_node_45 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 847 below describes the starting and ending position of this segment on each transcript.

Table 847 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Segment cluster HUMCAlXIA_node_47 according to the present invention is supported by 5 libraries. The number of libraries was determined ^"as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 848 below describes the starting and ending position of this segment on each transcript.

Table 848 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Segment cluster HUMCA lXIA_node_49 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA1XIA_T18. Table 849 below describes the starting and ending position of this segment on each transcript.

Table 849 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCAl XIA_P 15.

Segment cluster HUMCAl XI A_node_51 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCA IXIA_T 18. Table 850 below describes the starting and ending position of this segment on each transcript.

Table 850 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCA1XIA_P15.

Expression of Homo sapiens collagen, type XI, alpha 1 (COLIlAl) HUMCAlXlA transcripts which are detectable by amplicon as depicted in sequence name HUMCAlXlA seg55 in normal and cancerous breast tissues

Expression of Homo sapiens collagen, type XI, alpha 1 (COLIlAl) transcripts detectable by or according to HUMCAlXl seg55, HUMCAlXlA seg55 amplicon(s) and primers HUMCAlXlA seg55F and HUMCAlXlA seg55R was measured by real time PCR. In parallel the expression of four housekeeping genes -PBGD (GenBank Accession No. BC019323; amplicon - PBGD-amplicon), HPRTl (GenBank Accession No. NM_000194; amplicon - HPRTl -amplicon), SDHA (GenBank Accession No. NM_004168; amplicon - SDHA- amplicon), G6PD (GenBank Accession No. NM_000402; G6PD amplicon) was measured similarly. For each RT sample, the expression of the above amplicon was normalized to the geometric mean of the quantities of the housekeeping genes. The normalized quantity of each RT sample was then divided by the median of the quantities of the normal post-mortem (PM) samples (Sample Nos. 56-60, 63-67, Table 1, above), to obtain a value of fold up-regulation for each sample relative to median of the normal PM samples.

Figure 1 is a histogram showing over expression of the above- indicated Homo sapiens collagen, type XI, alpha 1 (COLI lAl) transcripts in cancerous breast samples relative to the normal samples. Values represent the average of duplicate experiments. Error bars indicate the minimal and maximal values obtained.

As is evident from Figure 22, the expression of Homo sapiens collagen, type XI, alpha 1 (COLIlAl) transcripts detectable by the above amplicon(s) in cancer samples was significantly higher than in the non-cancerous samples (Sample Nos. 56-60, 63-67 Table 1. Notably an over- expression of at least 5 fold was found in 18 out of 28 adenocarcinoma samples.

Primer pairs are also optionally and preferably encompassed within the present invention; for example, for the above experiment, the following primer pair was used as a non- limiting illustrative example only of a suitable primer pair: HUMCAlXlA seg55F forward primer; and HUMCAlXlA seg55R reverse primer.

The present invention also preferably encompasses any amplicon obtained through the use of any suitable primer pair; for example, for the above experiment, the following amplicon was obtained as a non- limiting illustrative example only of a suitable amplicon: HUMCAlXlA seg55. Forward primer- HUMCAlXlA seg55F: TTCTCATAGTATTCCATTGATTGGGTA

Reverse primer- HUMCAlXlA seg55R: CACCGGTATGGAGAATAGCGA Amplicon:

TTCTCATAGTATTCCATTGATTGGGTATACCAGGTTCTGTTTACTTTTACTTGGCAGT TGATAGAATAGGTGTAGTTTATACTTTTTCGCTATTCTCCATACCGGTG 22

Expression of Homo sapiens collagen, type XI, alpha 1 (COLIlAl) HUMCAlXlA transcripts which are detectable by amplicon as depicted in sequence name HUMCAlXlA seg55 in normal and cancerous lung tissues Expression of Homo sapiens collagen, type XI, alpha 1 (COLI lAl) transcripts detectable by or according to seg55, HUMCAlXlA seg55 amplicon(s) and primers HUMCAlXlA seg55F and HUMCAlXlA seg55R was measured by real time PCR. In parallel the expression of four housekeeping genes -PBGD (GenBank Accession No. BCOl 9323; amplicon - PBGD- amplicon), HPRTl (GenBank Accession No. NM_000194; amplicon - HPRTl -amplicon), Ubiquitin (GenBank Accession No. BC000449; amplicon - Ubiquitin-amplicon) and SDHA (GenBank Accession No. NM_004168; amplicon - SDHA-amplicon) was measured similarly. For each RT sample, the expression of the above amplicon was normalized to the geometric mean of the quantities of the housekeeping genes. The normalized quantity of each RT sample was then divided by the median of the quantities of the normal post-mortem (PM) samples (Sample Nos. 47-50, 90-93, 96-99, Table 1, above), to obtain a value of fold up-regulation for each sample relative to median of the normal PM samples.

Figure 1 is a histogram showing over expression of the above- indicated Homo sapiens collagen, type XI, alpha 1 (COLI lAl) transcripts in cancerous lung samples relative to the normal samples. Values represent the average of duplicate experiments. Error bars indicate the minimal and maximal values obtained. As is evident from Figure 23, the expression of Homo sapiens collagen, type XI, alpha 1

(COLIlAl) transcripts detectable by the above amplicon(s) in cancer samples was significantly

- higher than in the non-cancerous samples (Sample Nos. 47-50, 90-93, 96-99 Table 1). Notably an over- expression of at least 5 fold was found in 11 out of 15 adenocarcinoma samples, 11 out of 16 squamous cell carcinoma samples, and in 2 out of 4 large cell carcinoma samples.

Primer pairs are also optionally and preferably encompassed within the present invention; for example, for the above experiment, the following primer pair was used as a non- limiting illustrative example only of a suitable primer pair: HUMCAlXlA seg55F forward primer; and HUMCAlXlA seg55R reverse primer. The present invention also preferably encompasses any amplicon obtained through the use of any suitable primer pair; for example, for the above experiment, the following amplicon was obtained as a non- limiting illustrative example only of a suitable amplicon: HUMCAlXlA seg55. Forward primer -HUMCAlXlA seg55F: TTCTCATAGTATTCCATTGATTGGGTA Reverse primer- HUMCAlXlA seg55R: CACCGGTATGGAGAATAGCGA

Amplicon:

TTCTCATAGTATTCCATTGATTGGGTATACCAGGTTCTGTTTACTTTTACTTGGCAGT TGATAGAATAGGTGTAGTTTATACTTTTTCGCTATTCTCCATACCGGTG 23

Expression of Kinesin heavy chain isoform 5C M62096 transcripts which are detectable by amplicon as depicted in sequence name M62096 seg29 in normal and cancerous lung tissues

Expression of Kinesin heavy chain isoform 5C transcripts detectable by or according to M62096 seg29, M62096 seg29 amρlicon(s) and M62096 seg29F and M62096 seg29R primers was measured by real time PCR. In parallel the expression of four housekeeping genes -PBGD (GenBank Accession No. BCOl 9323; amplicon - PBGD-amplicon), HPRTl (GenBank Accession No. NM_000194; amplicon - HPRTl -amplicon), Ubiquitin (GenBank Accession No. BC000449; amplicon - Ubiquitin- amplicon) and SDHA (GenBank Accession No. NM_004168; amplicon - SDHA- amplicon) was measured similarly. For each RT sample, the expression of the above amplicon was normalized to the geometric mean of the quantities of the housekeeping genes. The normalized quantity of each RT sample was then divided by the median of the quantities of the normal post-mortem (PM) samples (Sample Nos. 47-50, 90-93, 96-99, Table 1, above), to obtain a value of fold up -regulation for each sample relative to median of the normal PM samples. Figure 24 is a histogram showing over expression of the above -indicated Kinesin heavy chain isoform 5C transcripts in cancerous lung samples relative to the normal samples. Values represent the average of duplicate experiments. Error bars indicate the minimal and maximal values obtained.

As is evident from Figure 24, the expression of Kinesin heavy chain isoform 5 C transcripts detectable by the above amplicon(s) in cancer samples was significantly higher than in the non-cancerous samples (Sample Nos. 47-50, 90-93, 96-99 Table 1). Notably an over- expression of at least 5 fold was found in 2 out of 15 adenocarcinoma samples, and in 7 out of 8 small cell carcinoma samples.

Primer pairs are also optionally and preferably encompassed within the present invention; for example, for the above experiment, the following primer pair was used as a non- limiting illustrative example only of a suitable primer pair: M62096 seg29F forward primer; and M62096 seg29R reverse primer.

The present invention also preferably encompasses any amplicon obtained through the use of any suitable primer pair; for example, for the above experiment, the following amplicon was obtained as a non- limiting illustrative example only of a suitable amplicon: M62096 seg29. Forward primer -M62096 seg29F: ATTGAATAATTCAGCACCTGAGGC Reverse primer- M62096 seg29R: TTCATATGGCTACTCCCCACCT - Amplicon:

ATTGAATAATTCAGCACCTGAGGCTGGTGGATGATTCTTTGCAATTTGGCAGGAATG GGAGAGTCGGGAGCAGTAGTTGGCAAGGTGGGGAGTAGCCATATGAA 24

DESCRIPTION FOR CLUSTER HUMKER56K Cluster HUMKER56K features 6 transcript(s) and 60 segment(s) of interest, the names for which are given in Tables 851 and 852, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 853.

Table 851 - Transcripts of interest

Transcript Name

HUMKER56K TlO

HUMKER56K T21

HUMKER56K T24

HUMKER56K T25

HUMKER56K T36

HUMKER56K T37

Table 852 - Segments of interest

Segment Name

HUMKER56K node 18

HUMKER56K node 19

HUMKER56K node 29

HUMKER56K node 31

HUMKER56K node 32

HUMKER56K node 35

HUMKER56K node 42

HUMKER56K node 67

HUMKER56K node 6

HUMKER56K node 7

HUMKER56K node 8

HUMKER56K node 9

HUMKER56K node 10

HUMKER56K node 11

HUMKER56K node 12

HUMKER56K node 13

HUMKER56K_ node J4

HUMKER56K node 15

HUMKER56K node 16

HUMKER56K node 17

HUMKER56K node 20

HUMKER56K node 21

HUMKER56K node 22

HUMKER56K node 23

HUMKER56K node 24

HUMKER56K node 25 HUMKER56K node 27

HUMKER56K node 28

HUMKER56K node 30

HUMKER56K node 33

HUMKER56K node 34

HUMKER56K node 36

HUMKER56K node 37

HUMKER56K node 38

HUMKER56K node 40

HUMKER56K, node 41

HUMKER56K node 43

HUMKER56K node 44

HUMKER56K node 46

HUMKER56K node 47

HUMKER56K node 49

HUMKER56K node 50

HUMKER56K node 51

HUMKER56K node 52

HUMKER56K node 53

HUMKER56K node 54

HUMKER56K node 55

HUMKER56K node 56

HUMKER56K node 57

HUMKER56K node 58

HUMKER56K node 59

HUMKER56K node 60

HUMKER56K node 61

HUMKER56K node 62

HUMKER56K node 63

HUMKER56K node 64

HUMKER56K node 65

HUMKER56K node 66

HUMKER56K node 68

HUMKER56K node 69

Table 853 - Proteins of interest

These sequences are variants of the known protein Keratin, type II cytoskeletal 6A (SwissProt accession identifier K2CA_HUMAN; known also according to the synonyms Cytokeratin 6A; CK 6A; K6a keratin), referred to herein as the previously known protein.

Protein Keratin, type II cytoskeletal 6A is known or believed to have the following function(s): THEPxE ARE TWO TYPES OF CYTOSKELETAL AND MICROFIBRILLAR KERATIN: I (ACIDIC; 40-55 IdDa) [K9 TO K20] AND II (NEUTRAL TO BASIC; 56-70 kDa) [Kl TO K8]. BOTH A BASIC AND AN ACIDIC KERATIN ARE REQUIRED FOR FILAMENT ASSEMBLY. The sequence for protein Keratin, type II cytoskeletal 6A is given at the end of the application, as "Keratin, type II cytoskeletal 6A amino acid sequence". Known polymorphisms for this sequence are as shown in Table 854.

Table 854 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: ectoderm development, which are annotation(s) related to Biological Process; structural protein of cytoskeleton, which are annotation(s) related to Molecular Function; and intermediate filament, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslmk, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>. Cluster HUMKER56K can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 25 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 25 and Table 855. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: a mixture of malignant tumors from different tissues, head and neck malignant tumors, myosarcoma and pancreas carcinoma.

25

Table 855 - Normal tissue distribution

Table 856 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMKER56K features 60 segment(s), which were listed in Table 852 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMKER56K_node_18 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 857 below describes the starting and ending position of this segment on each transcript.

Table 857 - Segment location on transcripts

I HUMKER56K T37 | I 484 1 641 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K P6 and HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P17, HUMKER56KJP19 and HUMKER56KJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_19 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10 and HUMKER56K_T36. Table 858 below describes the starting and ending position of this segment on each transcript.

Table 858 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKER56K P20. This segment can also be found in the following protein(s): HUMKER56K_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K__node_29 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T25, HUMKER56K_T36 and

HUMKER56K T37. Table 859 below describes the starting and ending position of this segment on each transcript.

Table 859 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K P20. This segment can also be found in the following protein(s): HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_31 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T24 and HUMKER56K_T37. Table 860 below describes the starting and ending position of this segment on each transcript.

Table 860 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56KJP19, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_32 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21,

HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table

861 below describes the starting and ending position of this segment on each transcript.

Table 861 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K P26. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56KJP17, HUMKER56K_P19 and

HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_35 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T21. Table 862 below describes the starting and ending position of this segment on each transcript.

Table 862 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKER56K_P17.

Segment cluster HUMKER56K_node_42 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 863 below describes the starting and ending position of this segment on each transcript.

Table 863 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56KJP19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_67 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 864 below describes the starting and ending position of this segment on each transcript.

Table 864 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP6, HUMKER56KJP17, HUMKER56KJP19, HUMKER56K P20 and HUMKER56K P26.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster HUMKER56K_node_6 according to the present invention is supported by 27 libraries. The number of libraπes was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 865 below describes the starting and ending position of this segment on each transcript.

Table 865 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6, HUMKER56KJP17, HUMKER56K_P19, HUMKER56K P20 and HUMKER56K P26.

Segment cluster HUMKER56K_node_7 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 866 below describes the starting and ending position of this segment on each transcript.

Table 866 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6 and HUMKER56KJP20. This segment can also be found in the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_8 according to the present invention can be found in the following transcript(s): HUMKER56KJ10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 867 below describes the starting and ending position of this segment on each transcript.

Table 867 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6 and HUMKER56KJP20. This segment can also be found in the following protein(s): HUMKER56K_P17, HUMKER56KJP19 and

HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_9 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HUMKER56K_T10, HUMKER56K_T21,

HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table

868 below describes the starting and ending position of this segment on each transcript.

Table 868 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6 and HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and

HUMKER56KJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_10 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 869 below describes the starting and ending position of this segment on each transcript.

Table 869 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6 and HUMKER56KJP20. This segment can also be found in the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56KJP26, since it is in the coding region for the corresponding transcript. Segment cluster HUMKER56K_node_l 1 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 870 below describes the starting and ending position of this segment on each transcript.

Table 870 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6 and HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56KJP17, HUMKER56KJP19 and

HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_12 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 871 below describes the starting and ending position of this segment on each transcript.

Table 871 - Segment location on transcripts

HUMKER56K T37 275 298

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP6 and HUMKER56KJP20. This segment can also be found in the following protein(s): HUMKER56KJP17, HUMKER56KJP19 and HUMKER56KJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_13 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56KJT25, HUMKER56K_T36 and HUMKER56K_T37. Table 872 below describes the starting and ending position of this segment on each transcript.

Table 872 - Segment location on transcripts

This segment can te found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): HUMKER56KJP6 and HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_14 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K J24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 873 below describes the starting and ending position of this segment on each transcript.

Table 873 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6 and HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56KJP17, HUMKER56KJP19 and HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_15 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 874 below describes the starting and ending position of this segment on each transcript.

Table 874 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6 and HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_16 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 875 below describes the starting and ending position of this segment on each transcript.

Table 875 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6 and HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P17, HUMKER56KJP19 and HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_17 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 876 below describes the starting and ending position of this segment on each transcript.

Table 876 - Segment location on transcripts

This segment can be found in both coding and non-codmg regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP6 and HUMKER56KJP20. This segment can also be found in the following protein(s): HUMKER56KJP17, HUMKER56KJP19 and HUMKER56KJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_20 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K__T37. Table 877 below describes the starting and ending position of this segment on each transcript.

Table 877 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56K_P17, HUMKER56KJP19 and HUMKER56KJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_21 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_TlO, HUMKER56K_T21, HUMKER56KJT24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 878 below describes the starting and ending position of this segment on each transcript.

Table 878 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56K_P17, HUMKER56K_P19 and HUMKER56KJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_22 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table

879 below describes the starting and ending position of this segment on each transcript.

Table 879 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56KJP17, HUMKER56K_P19 and HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_23 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 880 below describes the starting and ending position of this segment on each transcript.

Table 880 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56KJP6, HUMKER56K_P17, HUMKER56K_P19 and

HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_24 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 881 below describes the starting and ending position of this segment on each transcript.

Table 881 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP20. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56K_P17, HUMKER56K_P19 and

HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_25 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 882 below describes the starting and ending position of this segment on each transcript.

Table 882 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56KJP17, HUMKER56K_P19 and HUMKER56K_P26, since it is in the coding region for the corresponding transcript. Segment cluster HUMKER56K_node_27 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 883 below describes the starting and ending position of this segment on each transcript.

Table 883 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the 0 following protein(s): HUMKER56K P20. This segment can also be found in the following

_ _ protein(s): HUMKER56KJP6, HUMKER56KJP17, HUMKER56K JP19 and

HUMKER56KJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_28 according to the present invention is supported 5 by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following fanscript(s): HUMKER56K_T10, HUMKER56K_T21,

HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table

884 below describes the starting and ending position of this segment on each transcript.

Table 884 - Segment location on transcripts

I HUMKER56K T37 I 879 I 1 917 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P20. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_30 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 885 below describes the starting and ending position of this segment on each transcript.

Table 885 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_33 according to the present invention can be found in the following transcriρt(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 886 below describes the starting and ending position of this segment on each transcript. Table 886 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56KJP6, HUMKER56K_P17 and

HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_34 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K T37. Table 887 below describes the starting and ending position of this segment on each transcript.

Table 887 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P19 and HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56K_P6, HUMKER56K_P17 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript. Segment cluster HUMKER56K_node_36 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 888 below describes the starting and ending position of this segment on each transcript.

Table 888 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP17, HUMKER56KJP19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and

HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_37 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 889 below describes the starting and ending position of this segment on each transcript. Table 889 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56KJP19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56KJP6 and HUMKER56KJP20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_38 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 890 below describes the starting and ending position of this segment on each transcript.

Table 890 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP17, HUMKER56K_P19 and HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56KJP6 and HUMKER56KJP20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56Kjiode__40 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K__T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 891 below describes the starting and ending position of this segment on each transcript. Table 891 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56KJ^>26. This segment can also be found in the following protein(s): HUMKER56K_P6 and

HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_41 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 892 below describes the starting and ending position of this segment on each transcript.

Table 892 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP17, HUMKER56KJP19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcπpt.

Segment cluster HUMKER56K_node_43 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 893 below describes the starting and ending position of this segment on each transcript.

Table 893 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_44 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 894 below describes the starting and ending position of this segment on each transcript. Table 894 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56KJP6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_46 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 895 below describes the starting and ending position of this segment on each transcript.

Table 895 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56KJP20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_47 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 896 below describes the starting and ending position of this segment on each transcript. Table 896 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP17, HUMKER56K_P19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and

HUMKER56KJP20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_49 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 897 below describes the starting and ending position of this segment on each transcript.

Table 897 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP17, HUMKER56KJP19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcπpt.

Segment cluster HUMKER56K_node_50 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 898 below describes the starting and ending position of this segment on each transcript.

Table 898 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP17, HUMKER56KJP19 and HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_51 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56KJT24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56KJ37. Table 899 below describes the starting and ending position of this segment on each transcript. Table 899 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56KJP6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_52 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 900 below describes the starting and ending position of this segment on each transcript.

Table 900 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP17, HUMKER56K_P19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56KJP6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_53 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 901 below describes the starting and ending position of this segment on each transcript. Table 901 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56KJP19 and HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56K_P6 and

HUMKER56KJP20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_54 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 902 below describes the starting and ending position of this segment on each transcript.

Table 902 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP17, HUMKER56K_P19 and HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript. Segment cluster HUMKER56K__node_55 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 903 below describes the starting and ending position of this segment on each transcript.

Table 903 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56K_P6 and

HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_56 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 904 below describes the starting and ending position of this segment on each transcript.

Table 904 - Segment location on transcripts

I HUMKER56K T37 I 2014 I I 2020 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56K_P19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_57 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 905 below describes the starting and ending position of this segment on each transcript.

Table 905 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56KJP19 and HUMKER56KJP26. This segment can also be found in the following protein(s): HUMKER56KJP6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_58 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 906 below describes the starting and ending position of this segment on each transcript.

Table 906 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K P17, HUMKER56K_P19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and

HUMKER56K_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKER56K_node_59 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 907 below describes the starting and ending position of this segment on each transcript.

Table 907 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P17, HUMKER56KJP19 and HUMKER56K_P26. This segment can also be found in the following protein(s): HUMKER56K_P6 and HUMKER56K_P20, since it is in the coding region for the corresponding transcript. Segment cluster HUMKER56K_node_60 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 908 below describes the starting and ending position of this segment on each transcript.

Table 908 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP6, HUMKER56K_P17, HUMKER56KJP19, HUMKER56K P20 and HUMKER56K P26.

Segment cluster HUMKER56K_node_61 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 909 below describes the starting and ending position of this segment on each transcript.

Table 909 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP6, HUMKER56K_P17, HUMKER56KJP19, HUMKER56K_P20 and HUMKER56KJP26.

Segment cluster HUMKER56K_node_62 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 910 below describes the starting and ending position of this segment on each transcript.

Table 910 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6, HUMKER56KJP17, HUMKER56K_P19, HUMKER56K P20 and HUMKER56K P26.

Segment cluster HUMKER56K_node_63 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56KJ25, HUMKER56K_T36 and HUMKER56K_T37. Table 911 below describes the starting and ending position of this segment on each transcript. Table 911 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP6, HUMKER56K_P17, HUMKER56K_P19, HUMKER56K_P20 and HUMKER56KJ^>26.

Segment cluster HUMKER56K_node_64 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 912 below describes the starting and ending position of this segment on each transcript.

Table 912 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP6, HUMKER56K JP17, HUMKER56KJP19, HUMKER56K P20 and HUMKER56K P26.

Segment cluster HUMKER56K_node_65 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 913 below describes the starting and ending position of this segment on each transcript.

Table 913 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56KJP6, HUMKER56KJP17, HUMKER56K_P19, HUMKER56K P20 and HUMKER56K P26.

Segment cluster HUMKER56K_node_66 according to the present invention can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 914 below describes the starting and ending position of this segment on each transcript. Table 914 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6, HUMKER56K_P17, HUMKER56KJP19, HUMKER56K_P20 and HUMKER56KJP26.

Segment cluster HUMKER56K_node_68 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 915 below describes the starting and ending position of this segment on each transcript.

Table 915 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6, HUMKER56K_P17, HUMKER56K_P19, HUMKER56K P20 and HUMKER56K P26.

Segment cluster HUMKER56K_node_69 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKER56K_T10, HUMKER56K_T21, HUMKER56K_T24, HUMKER56K_T25, HUMKER56K_T36 and HUMKER56K_T37. Table 916 below describes the starting and ending position of this segment on each transcript.

Table 916 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKER56K_P6, HUMKER56K_P17, HUMKER56KJP19, HUMKER56K P20 and HUMKER56K P26. DESCRIPTION FOR CLUSTER HUMKERK5A

Cluster HUMKERK5A features 13 transcript(s) and 68 segment(s) of interest, the names for which are given in Tables 917 and 918, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 919.

Table 917 - Transcripts of interest

Transcript Name

HUMKERK5A Tl

HUMKERK5A T14

HUMKERK5A T15

HUMKERK5A T20

HUMKERK5A T24

HUMKERK5A T26

HUMKERK5A_ T27

HUMKERK5A T29

HUMKERK5A T31

HUMKERK5A T33

HUMKERK5A T39

HUMKERK5A T40

HUMKERK5A T53

Table 918 - Segments of interest

Segment Name

HUMKERK5A node 4

HUMKERK5A node 7

HUMKERK5A node 33

HUMKERK5A node 34

HUMKERK5A node 36

HUMKERK5A node 42

HUMKERK5A node 47

HUMKERK5A node 50

HUMKERK5A node 74

HUMKERK5A node 76

HUMKERK5A node 2

HUMKERK5A node 5 HUMKERK5A node 6

HUMKERK5A node 8

HUMKERK5A node 9

HUMKERK.5A node 10

HUMKERK5A node 11

HUMKERK5A node 12

HUMKERK5A node 13

HUMKERK5A node 14

HUMKERK5A node 15

HUMKERK5A node 16

HUMKERK5A node 18

HUMKERK5A node 20

HUMKERK5A node 21

HUMKERK5A node 22

HUMKERK5A node 24

HUMKERK5A node 26

HUMKERK5A node 27

HUMKERK5A node 28

HUMKERK5A node 29

HUMKERX5A node 30

HUMKERK5A node 31

HUMKERK5A node 32

HUMKERK5A node 35

HUMKERK5A node 37

HUMKERK5A node 38

HUMKERK5A_ node 39

HUMKERK5A node 40

HUMKERK5A node 41

HUMKERK5A node 43

HUMKEKEC5A node 44

HUMKERK5A node 45

HUMKERK5A node 46

HUMKERK5A node 48

HUMKERK5A node 51

HUMKERK5A node 52

HUMKERK5A node 53

HUMKERK5A node 54

HUMKERK5A node 55

HUMKERK5A node 56

HUMKERK5A node 57

HUMKERK5A_ _node_ _58

HUMKERK5A node 59

HUMKERK5A node 60

HUMKERK5A node 61 HUMKERK5A node 62

HUMKERK5A node 63

HUMKERK5A node 64

HUMKERK5A node 65

HUMKERK5A node 66

HUMKERK5A node 67

HUMKERK5A node 68

HUMKERK5A node 69

HUMKERK5A node 70

HUMKERK5A_ node .71

HUMKERK5A node 72

HUMKERK5A node 73

Table 919 - Proteins of interest

These sequences are variants of the known protein Keratin, type II cytoskeletal 5 (SwissProt accession identifier K2C5__HUMAN; known also according to the synonyms Cytokeratin 5; K5; CK 5; 58 kDa cytokeratin), referred to herein as the previously known protein.

The sequence for protein Keratin, type II cytoskeletal 5 is given at the end of the application, as "Keratin, type II cytoskeletal 5 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 920.

Table 920 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: epidermal differentiation, which are annotation(s) related to Biological Process; structural protein of cytoskeleton, which are annotation(s) related to Molecular Function; and intermediate filament, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HUMKERK5A can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 26 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 26 and Table 921. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: transitional cell carcinoma, a mixture of malignant tumors from different tissues and pancreas carcinoma.

Table 921 - Normal tissue distribution

Table 922 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 923.

Table 923 - Oligonucleotides related to this cluster

As noted above, cluster HUMKERK5A features 68 segment(s), which were listed in Table 918 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster HUMKERK5A_node_4 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 924 below describes the starting and ending position of this segment on each transcript.

Table 924 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5AJP10, HUMKERK5A_P15, HUMKERK5A P19 and HUMKERK5A P23.

Segment cluster HUMKERK5A_node_7 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1 , HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A__T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 925 below describes the starting and ending position of this segment on each transcript. Table 925 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5AJH5, HUMKERK5A_P19, HUMKERK5AJP21, HUMKERK5AJP23 and HUMKERK5A_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_33 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T14 and HUMKERK5A_T33. Table 926 below describes the starting and ending position of this segment on each transcript.

Table 926 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERK5A_P9.

Segment cluster HUMKERK5A_node_34 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 927 below describes the starting and ending position of this segment on each transcript.

Table 927 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP9. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_36 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK.5A_T20, HUMKERK5A_T33 and

HUMKERK5A_T39. Table 928 below describes the starting and ending position of this segment on each transcript.

Table 928 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-codmg region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9. This segment can also be found in the following protein(s): HUMKERK5A_P15, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_42 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T29, HUMKERK5A_T39 and HUMKERK5A_T40. Table 929 below describes the starting and ending position of this segment on each transcript.

Table 929 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P15. This segment can also be found in the following protein(s): HUMKERK5A_P23, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_47 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T24, HUMKERK5A_T26 and

HUMKERK5A_T40. Table 930 below describes the starting and ending position of this segment on each transcript.

Table 930 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_50 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T26. Table 931 below describes the starting and ending position of this segment on each transcript.

Table 931 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P19.

Segment cluster HUMKERK5A_node_74 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A__T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 932 below describes the starting and ending position of this segment on each transcript.

Table 932 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P1, HUMKERK5AJP9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A_P25.

Segment cluster HUMKERK5A_node_76 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A T53. Table 933 below describes the starting and ending position of this segment on each transcript.

Table 933 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERK5AJP40.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster HUMKERK5A_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T27 and HUMKERK5A_T53. Table 934 below describes the starting and ending position of this segment on each transcript.

Table 934 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P1, HUMKERK5AJP21 and HUMKERK5A_P40.

Segment cluster HUMKERK5A_node_5 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 935 below describes the starting and ending position of this segment on each transcript.

Table 935 - Segment location on transcripts

HUMKERK5A T53 98 120

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5AJP15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_6 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 936 below describes the starting and ending position of this segment on each transcript. Table 936 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_8 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 937 below describes the starting and ending position of this segment on each transcript.

Table 937 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5AJP9, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5AJP23 and HUMKERK5AJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_9 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 938 below describes the starting and ending position of this segment on each transcript.

Table 938 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5AJP9, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A_P40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_10 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14,

HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26,

HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39,

HUMKERK5A_T40 and HUMKERK5A_T53. Table 939 below describes the starting and ending position of this segment on each transcript. Table 939 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5AJP15, HUMKERK5A_P19, HUMKERK5AJP21, HUMKERK5A P23 and HUMKERK5AJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_l 1 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 940 below describes the starting and ending position of this segment on each transcript. Table 940 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HDMKERK5A_P1, HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5AJP19, HUMKERK5A_P23 and HUMKERK5AJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_12 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14,

HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26,

HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and

HUMKERK5A T53. Table 941 below describes the starting and ending position of this segment on each transcript.

Table 941 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5AJP23 and HUMKERK5AJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_13 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 942 below describes the starting and ending position of this segment on each transcript. Table 942 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P23 and HUMKERK5AJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_14 according to the present invention is supported by 53 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 943 below describes the starting and ending position of this segment on each transcript.

Table 943 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP10. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5AJP19, HUMKERK5A_P23 and HUMKERK5AJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_15 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T29, HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53. Table 944 below describes the starting and ending position of this segment on each transcript.

Table 944 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5AJP15, HUMKERK5A_P19, HUMKERK5AJP23 and HUMKERK5AJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_16 according to the present invention can be found in the following transcriρt(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T29,

HUMKERK5A_T33, HUMKERK5A_T39, HUMKERK5A_T40 and HUMKERK5A_T53.

Table 945 below describes the starting and ending position of this segment on each transcript.

Table 945 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P23 and HUMKERK.5AJP40, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5 Ajnode_l 8 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5 A_T31. Table 946 below describes the starting and ending position of this segment on each transcript.

Table 946 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP25.

Segment cluster HUMKERK5A_node_20 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14,

HUMKEKK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26,

HUMKERK5A_T29, HUMKERK5AJI31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 947 below describes the starting and ending position of this segment on each transcript.

Table 947 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10 and HUMKERK5A_P25. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_21 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HIMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 948 below describes the starting and ending position of this segment on each transcript.

Table 948 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10 and HUMKERK5A_P25. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5AJP15, HUMKERK5A_P19 and HUMKERK5A_P23, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node__22 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15,

HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T29,

HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40.

Table 949 below describes the starting and ending position of this segment on each transcript.

Table 949 - Segment location on transcripts

I HUMKERK5A T40 I 1150 I I 1161 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10 and HUMKERK5AJP25. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5AJP19 and HUMKERK5AJP23, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_24 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T15. Table 950 below describes the starting and ending position of this segment on each transcript.

Table 950 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P10.

Segment cluster HUMKERK5A_node_26 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 951 below describes the starting and ending position of this segment on each transcript. Table 951 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P25. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21 and HUMKERK5A_P23, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_27 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERJC5A_T39 and HUMKERK5A_T40. Table 952 below describes the starting and ending position of this segment on each transcript. Table 952 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P25. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5 AJPlO, HUMKERK5AJP15, HUMKERK5AJP19, HUMKERK5AJP21 and HUMKERK5A_P23, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_28 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5 A_T31. Table 953 below describes the starting and ending position of this segment on each transcript.

Table 953 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP25.

Segment cluster HUMKERK5A_node_29 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 954 below describes the starting and ending position of this segment on each transcript. Table 954 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERK5A P1, HUMKERK5AJP9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5AJP21, HUMKERK5A_P23 and HUMKERK5A_P25.

Segment cluster HUMKERK5A_node_30 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 955 below describes the starting and ending position of this segment on each transcript.

Table 955 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERK5A P1, HUMKERK5A_P9, HUMKERK5A_P10, HUMKERK5AJP15, HUMKERK5A_P19, HUMKERK5AJP21, HUMKERK5A_P23 and HUMKERK5A_P25.

Segment cluster HUMKERK5A_node_31 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A__T39 and HUMKERK5A_T40. Table 956 below describes the starting and ending position of this segment on each transcript.

Table 956 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5AJP21, HUMKERJC5A_P23 and HUMKERK5A_P25.

Segment cluster HUMKERK5A_node_32 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 957 below describes the starting and ending position of this segment on each transcript.

Table 957 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERK5A P1, HUMKERK5AJP9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A P21, HUMKERK5A P23 and HUMKERK5A_P25.

Segment cluster HUMKERK5A_node_35 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HIMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 958 below describes the starting and ending position of this segment on each transcript.

Table 958 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P15,

HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_37 according to the present invention can be found in the following transcript(s): HUMKERK5A_T20, HUMKERK5A_T33 and HUMKERK5A_T39. Table 959 below describes the starting and ending position of this segment on each transcript.

Table 959 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP15 and HUMKERK5A_P9.

Segment cluster HUMKERK5A_node_38 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 960 below describes the starting and ending position of this segment on each transcript.

Table 960 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9 and HUMKERK5A_P15. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_39 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 961 below describes the starting and ending position of this segment on each transcript.

Table 961 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of trans cript(s) that are related to the following protein(s): HUMKERK5A_P9 and HUMKERK5A_P15. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5AJP10, HUMKERK5A_P19, HUMKERK5AJP21, HUMKERK5A_P23 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_40 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14,

HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26,

HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33,

HUMKERK5A_T39 and HUMKERK5A_T40. Table 962 below describes the starting and ending position of this segment on each transcript.

Table 962 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of tanscript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9 and HUMKERK5A_P15. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P10, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5AJ^>23 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_41 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A T1, HUMKERK5A_T14,

HUMKERK5A T15, HUMKERK5A T20, HUMKERK5A T24, HUMKERK5A_T26,

HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33,

HUMKERK5A_T39 and HUMKERK5A_T40. Table 963 below describes the starting and ending position of this segment on each transcript.

Table 963 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK.5AJP9 and HUMKERK5A_P15. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5AJP10, HUMKERK5AJP19, HUMKERK5AJP21, HUMKERK5A_P23 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_43 according to the present invention is supported by 63 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14,

HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HTJMKERK5A_T26,

HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33,

HUMKERK5A_T39 and HUMKERK5A_T40. Table 964 below describes the starting and ending position of this segment on each transcript.

Table 964 - Segment location on transcripts ^'

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15 and HUMKERK5AJP23. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P10, HUMKERK5A_P19, HUMKERK5A_P21 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_44 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5 A_T31 , HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 965 below describes the starting and ending position of this segment on each transcript.

Table 965 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK.5A_P15 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P10, HUMKERK5A_P19, HUMKERK5A_P21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript. Segment cluster HUMKERK5A_node_45 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1 , HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5 A_T31 , HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 966 below describes the starting and ending position of this segment on each transcript.

Table 966 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P19, HUMKERK5A_P21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_46 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15,

HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 967 below describes the starting and ending position of this segment on each transcript.

Table 967 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15 and HUMKERK5AJP23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P19, HUMKERK5A_P21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_48 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 968 below describes the starting and ending position of this segment on each transcript.

Table 968 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5AJP10, HUMKERK5AJP21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5 A_node_51 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14,

HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26,

HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33,

HUMKERK5A_T39 and HUMKERK5A_T40. Table 969 below describes the starting and ending position of this segment on each transcript.

Table 969 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P21 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_52 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14,

HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24,- HUMKERK5A_T26,

HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33,

HUMKERK5A_T39 and HUMKERK5A_T40. Table 970 below describes the starting and ending position of this segment on each transcript.

Table 970 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5AJP23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5AJP21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_53 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1 , HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 971 below describes the starting and ending position of this segment on each transcript. Table 971 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5AJP15, HUMKERK5AJP19 and HUMKERK5A P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5 A_P10, HUMKERK5A_P21 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_54 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 972 below describes the starting and ending position of this segment on each transcript.

Table 972 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_55 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15,

HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 973 below describes the starting and ending position of this segment on each transcript.

Table 973 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5AJP23. This segment can also be found in the following protein(s): HUMKERK5AJP1, HUMKERK5A_P10, HUMKERK5A_P21 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_56 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 974 below describes the starting and ending position of this segment on each transcript.

Table 974 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5AJP21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_57 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 975 below describes the starting and ending position of this segment on each transcript. Table 975 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5AJP15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5AJP21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_58 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 976 below describes the starting and ending position of this segment on each transcript. Table 976 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_59 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 977 below describes the starting and ending position of this segment on each transcript.

Table 977 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P21 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript. Segment cluster HUMKERK5A_node_60 according to the present invention is supported by 55 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 978 below describes the starting and ending position of this segment on each transcript.

Table 978 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5AJP23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5AJP21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_61 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 979 below describes the starting and ending position of this segment on each transcript.

Table 979 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5AJP10, HUMKERK5A_P21 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK.5A_node_62 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 980 below describes the starting and ending position of this segment on each transcript.

Table 980 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P21 and HUMKERK5AJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_63 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 981 below describes the starting and ending position of this segment on each transcript.

Table 981 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_64 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14,

HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26,

HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33,

HUMKERK5A_T39 and HUMKERK5A_T40. Table 982 below describes the starting and ending position of this segment on each transcript.

Table 982 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP9, HUMKERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5 A_P21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_65 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 983 below describes the starting and ending position of this segment on each transcript.

Table 983 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 984.

Table 984 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJ^>9, HUMKJERK5A_P15, HUMKERK5A_P19 and HUMKERK5A_P23. This segment can also be found in the following protein(s): HUMKERK5A_P1, HUMKERK5A_P10, HUMKERK5A_P21 and HUMKERK5A_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERK5A_node_66 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A T39 and HUMKERK5A_T40. Table 985 below describes the starting and ending position of this segment on each transcript.

Table 985 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP1, HUMKERK5AJP9, HUMKERK5AJP10, HUMKERK5A_P15, HUMKERK5AJP19, HUMKERK5A_P21, HUMKERK5AJP23 and HUMKERK5A P25. Segment cluster HUMKERK5A_node_67 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 986 below describes the starting and ending position of this segment on each transcript.

Table 986 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5AJP10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A P25.

Segment cluster HUMKERK5A_node_68 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 987 below describes the starting and ending position of this segment on each transcript. Table 987 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A P25.

Segment cluster HUMKERK5A_node_69 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK.5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 988 below describes the starting and ending position of this segment on each transcript.

Table 988 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protem(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5AJP19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A P25.

Segment cluster HUMKERK5A_node_70 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5 A_T31 , HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 989 below describes the starting and ending position of this segment on each transcript.

Table 989 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5A_P10, HUMKERK5AJP15, HUMKERK5 A_P 19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A_P25.

Segment cluster HUMKERK5A_node_71 accordmg to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 990 below describes the starting and ending position of this segment on each transcript.

Table 990 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP1, HUMKERK5AJP9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A P25.

Segment cluster HUMKERK5A_node_72 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 991 below describes the starting and ending position of this segment on each transcript.

Table 991 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERK5A_P1, HUMKERK5A_P9, HUMKERK5A_P10, HUMKERK5A_P15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A_P25.

Segment cluster HUMKERK5A_node_73 according to the present invention can be found in the following transcript(s): HUMKERK5A_T1, HUMKERK5A_T14, HUMKERK5A_T15, HUMKERK5A_T20, HUMKERK5A_T24, HUMKERK5A_T26, HUMKERK5A_T27, HUMKERK5A_T29, HUMKERK5A_T31, HUMKERK5A_T33, HUMKERK5A_T39 and HUMKERK5A_T40. Table 992 below describes the starting and ending position of this segment on each transcript.

Table 992 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERK5AJP1, HUMKERK5A_P9, HUMKERK5A_P10, HUMKERK5AJP15, HUMKERK5A_P19, HUMKERK5A_P21, HUMKERK5A_P23 and HUMKERK5A P25.

DESCRIPTION FOR CLUSTER HUMMPP2X

Cluster HUMMPP2X features 5 transcript(s) and 29 segment(s) of interest, the names for which are given in Tables 993 and 994, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 995.

Table 993 - Transcripts of interest

Transcript Name

HUMMPP2X T3

HUMMPP2X T9

HUMMPP2X T16

HUMMPP2X T22

HUMMPP2X T23

Table 994 - Segments of interest

Segment Name

HUMMPP2X node 0

HUMMPP2X node 2 HUMMPP2X node 4

HUMMPP2X node 7

HUMMPP2X node 10

HUMMPP2X node 11

HUMMPP2X node 17

HUMMPP2X node 19

HUMMPP2X node 21

HUMMPP2X node 22

HUMMPP2X node 23

HUMMPP2X_ node _28

HUMMPP2X node 29

HUMMPP2X node 32

HUMMPP2X node 34

HUMMPP2X node 35

HUMMPP2X node 40

HUMMPP2X node 43

HUMMPP2X node 14

HUMMPP2X node 18

HUMMPP2X node 20

HUMMPP2X node 33

HUMMPP2X node 36

HUMMPP2X node 37

HUMMPP2X node 38

HUMMPP2X node 39

HUMMPP2X node 41

HUMMPP2X node 42

HUMMPP2X node 44

Table 995 - Proteins of interest

These sequences are variants of the known protein Forkhead box protein Ml (SwissProt accession identifier FXM1_HUMAN; known also according to the synonyms Forkhead-related protein FKBLl 6; Hepatocyte nuclear factor 3 forkhead homolog 11; HNF-3/fork-head homo log- 11; HFH-11; Winged helix factor from INS-I cells; M-phase phosphoprotein 2; MPM- 2 reactive phosphoprotein 2; Transcription factor Trident), referred to herein as the previously known protein. Protein Forkhead box protein Ml is known or believed to have the following function(s): Transcriptional activator/ factor. May play a role in the control of cell proliferation. The sequence for protein Forkhead box protein Ml is given at the end of the application, as "Forkhead box protein Ml amino acid sequence". Known polymorphisms for this sequence are as shown in Table 996.

Table 996 - Amino acid mutations for Known Protein

Protein Forkhead box protein Ml localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription regulation; transcription, from Pol II promoter; oxidative stress response, which are annotation(s) related to Biological Process; transcription factor; RNA polymerase II transcription factor, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster HUMMPP2X can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 27 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 27 and Table 997. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, myosarcoma, skin malignancies and uterine malignancies.

Table 997 - Normal tissue distribution

Table 998 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMMPP2X features 29 segment(s), which were listed in Table 994 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMMPP2X_node__0 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T16. Table 999 below describes the starting and ending position of this segment on each transcript.

Table 999 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4 and HUMMPP2X_P13.

Segment cluster HUMMPP2X_node_2 according to the present invention is supported by

33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T16. Table 1000 below describes the starting and ending position of this segment on each transcript. Table 1000 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2XJP4. This segment can also be found in the following protein(s): HUMMPP2X_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMPP2X_node_4 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T16. Table 1001 below describes the starting and ending position of this segment on each transcript.

Table 1001 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4. This segment can also be found in the following protein(s): HUMMPP2X__P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMPP2X_node_7 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T16. Table 1002 below describes the starting and ending position of this segment on each transcript.

Table 1002 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4. This segment can also be found in the following protein(s): HUMMPP2X_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMPP2X_node_10 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X T23. Table 1003 below describes the starting and ending position of this segment on each transcript.

Table 1003 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P17.

Segment cluster HUMMPP2Xjnode_l 1 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3, HUMMPP2X_T16 and HUMMPP2X_T23. Table 1004 below describes the starting and ending position of this segment on each transcript.

Table 1004 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4. This segment can also be found in the following protein(s): HUMMPP2X_P13 and HUMMPP2X_P17, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMPP2X_node_17 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be fcund in the following transcript(s): HUMMPP2X_T9. Table 1005 below describes the starting and ending position of this segment on each transcript.

Table 1005 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_19 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1006 below describes the starting and ending position of this segment on each transcript.

Table 1006 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4. Segment cluster HUMMPP2X_node_21 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1007 below describes the starting and ending position of this segment on each transcript.

Table 1007 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_22 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3, HUMMPP2X_T9, HUMMPP2X_T16 and HUMMPP2X_T23. Table 1008 below describes the starting and ending position of this segment on each transcript. Table 1008 - Segment location on transcripts

This segment can be found in the following protein(s): HUMMPP2X_P4, HUMMPP2X P13 and HUMMPP2X P17.

Segment cluster HUMMPP2X_node_23 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T16. Table 1009 below describes the starting and ending position of this segment on each transcript. Table 1009 - Segment location on transcripts

This segment can be found in the following protein(s): HUMMPP2X_P13.

Segment cluster HUMMPP2X_node_28 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T22. Table 1010 below describes the starting and ending position of this segment on each transcript.

Table 1010 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMMPP2X_node_29 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T22 and HUMMPP2X_T23. Table 1011 below describes the starting and ending position of this segment on each transcript.

Table 1011 - Segment location on transcripts

This segment can be found in the following protein(s): HUMMPP2X_P17.

Segment cluster HUMMPP2X_node_32 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1012 below describes the starting and ending position of this segment on each transcript.

Table 1012 - Segment location on transcripts

This segment can be found in the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_34 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1013 below describes the starting and ending position of this segment on each transcript.

Table 1013 - Segment location on transcripts

This segment can be found in the following proteiα(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_35 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1014 below describes the starting and ending position of this segment on each transcript.

Table 1014 - Segment location on transcripts

This segment can be found in the following protein(s): HUMMPP2XJP4. Segment cluster HUMMPP2X_node_40 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1015 below describes the starting and ending position of this segment on each transcript.

Table 1015 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2XJP4.

Segment cluster HUMMPP2X_node_43 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1016 below describes the starting and ending position of this segment on each transcript.

Table 1016 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMMPP2X_node_14 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3. Table 1017 below describes the starting and ending position of this segment on each transcript.

Table 1017 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMPP2XJP4.

Segment cluster HUMMPP2X_node_18 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1018 below describes the starting and ending position of this segment on each transcript.

Table 1018 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_20 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3, HUMMPP2X_T9, HUMMPP2X_T16 and HUMMPP2X_T23. Table 1019 below describes the starting and ending position of this segment on each transcript.

Table 1019 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4. This segment can also be found in the following protein(s): HUMMPP2X_P13 and HUMMPP2X_P17, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMPP2X_node_33 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1020 below describes the starting and ending position of this segment on each transcript.

Table 1020 - Segment location on transcripts

This segment can be found in the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_36 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1021 below describes the starting and ending position of this segment on each transcript. Table 1021 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4. Segment cluster HUMMPP2X_node_37 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1022 below describes the starting and ending position of this segment on each transcript.

Table 1022 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_38 according to the present invention can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1023 below describes the starting and ending position of this segment on each transcript.

Table 1023 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_39 according to the present invention can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1024 below describes the starting and ending position of this segment on each transcript.

Table 1024 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_41 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X T3 and HUMMPP2X_T9. Table 1025 below describes the starting and ending position of this segment on each transcript.

Table 1025 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

Segment cluster HUMMPP2X_node_42 according to the present invention can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1026 below describes the starting and ending position of this segment on each transcript.

Table 1026 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4. Segment cluster HUMMPP2X_node_44 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMPP2X_T3 and HUMMPP2X_T9. Table 1027 below describes the starting and ending position of this segment on each transcript.

Table 1027 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMPP2X_P4.

DESCRIPTION FOR CLUSTER HUMPFK

Cluster HUMPFK features 20 transcript(s) and 58 segment(s) of interest, the names for which are given in Tables 1028 and 1029, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1030.

Table 1028 - Transcripts of interest

Transcript Name

HUMPFK Tl

HUMPFK T2

HUMPFK T4

HUMPFK T5

HUMPFK T6

HUMPFK T7

HUMPFK T8

HUMPFK TI l

HUMPFK T12

HUMPFK T13

HUMPFK T14

HUMPFK T15

HUMPFK T16

HUMPFK T18

HUMPFK T26

HUMPFK T27

HUMPFK T30 HUMPFK T45

HUMPFK T49

HUMPFK T50

Table 1029 - Segments of interest

Segment Name

HUMPFK node 0

HUMPFK node 5

HUMPFK node 14

HUMPFK node 17

HUMPFK node 19

HUMPFK node 23

HUMPFK node 25

HUMPFK node 26

HUMPFK node 27

HUMPFK node 29

HUMPFK node _38

HUMPFK node 44

HUMPFK node 48

HUMPFK node 49

HUMPFK node 54

HUMPFK node 57

HUMPFK node 58

HUMPFK node 59

HUMPFK node 60

HUMPFK node 61

HUMPFK node 62

HUMPFK node 63

HUMPFK node 64

HUMPFK node 65

HUMPFK node 83

HUMPFK node 91

HUMPFK _node_ _93

HUMPFK node 99

HUMPFK node 102

HUMPFK node 104

HUMPFK node 3

HUMPFK node 6

HUMPFK node 12

HUMPFK node 16

HUMPFK node 21

HUMPFK node 28

HUMPFK node 31 HUMPFK node 33

HUMPFK node 34

HUMPFK node 36

HUMPFK node 40

HUMPFK node 42

HUMPFK node 47

HUMPFK node 50

HUMPFK node 51

HUMPFK node 53

HUMPFK node _67

HUMPFK node 69

HUMPFK node 73

HUMPFK node 74

HUMPFK node 78

HUMPFK node 79

HUMPFK node 81

HUMPFK node 82

HUMPFK node 87

HUMPFK node 89

HUMPFK node 101

HUMPFK node 103

Table 1030 - Proteins of interest

These sequences are variants of the known protein 6-phosphofructokinase, type C (SwissProt accession identifier K6PP HUMAN; known also according to the synonyms EC 2.7.1.1 1 ; Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1 -kinase isozyme C; PFK- C; 6-phosphofructokinase, platelet type), referred to herein as the previously known protein.

The sequence for protein 6-phosphofructokinase, type C is given at the end of the application, as "6-phosphofructokinase, type C amino acid sequence". Known polymorphisms for this sequence are as shown in Table 1031.

Table 1031 -Amino acid mutations for- Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: glycolysis, which are annotation(s) related to Biological Process; magnesium binding; 6-phosphofructokinase; kinase; transferase, which are annotation(s) related to Molecular Function; and cytoplasm; 6-phosphofructokinase, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster HUMPFK can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 28 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 28 and Table 1032. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and myosarcoma.

Table 1032 - Normal tissue distribution

Table 1033 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMPFK features 58 segment(s), which were listed in Table

1029 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMPFK_node_0 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27, HUMPFK_T30, HUMPFK_T49 and HUMPFK_T50. Table 1034 below describes the starting and ending position of this segment on each transcript. Table 1034 - Segment location on franscripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P8 and HUMPFK_P9. This segment can also be found in the following protein(s): HUMPFK_P6, HUMPFK_P7, HUMPFKJ⁵IO, HUMPFK_P13, HUMPFK_P25 and HUMPFK P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_5 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2. Table 1035 below describes the starting and ending position of this segment on each transcript.

Table 1035 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P3.

Segment cluster HUMPFK_node_14 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T4. Table 1036 below describes the starting and ending position of this segment on each transcript.

Table 1036 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P4.

Segment cluster HUMPFK_node_17 according to the present invention is supported by 2 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMPFK_T49. Table 1037 below describes the starting and ending position of this segment on each transcript.

Table 1037 - Segment location on transcripts

This segment can be found in the following ρrotein(s): HUMPFK_P25.

Segment cluster HUMPFK_node_19 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T50. Table 1038 below describes the starting and ending position of this segment on each transcript.

Table 1038 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P26.

Segment cluster HUMPFK_node_23 according to the present invention is supported by

76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HUMPFKJT2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_Tl 5, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1039 below describes the starting and ending position of this segment on each transcript.

Table 1039 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK P8 and HUMPFKJP9. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFKJP5, HUMPFK_P6, HUMPFK_P7, HUMPFK_P10 and HUMPFKJP13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_25 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1040 below describes the starting and ending position of this segment on each transcript. Table 1040 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P8 and HUMPFK_P9. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFK_P5, HUMPFK_P6, HUMPFK_P7, HUMPFK_P10 and HUMPFKJP13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_26 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T12, HUMPFK_Tl 5 and HUMPFK_T18. Table 1041 below describes the starting and ending position of this segment on each transcript.

Table 1041 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJP8 and HUMPFK_P9.

Segment cluster HUMPFK_node_27 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T12 and HUMPFK_T15. Table 1042 below describes the starting and ending position of this segment on each transcript. Table 1042 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P8 and HUMPFK_P9.

Segment cluster HUMPFK_node_29 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T15. Table 1043 below describes the starting and ending position of this segment on each transcript.

Table 1043 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P9.

Segment cluster HUMPFK_node_38 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_Tl 6, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1044 below describes the starting and ending position of this segment on each transcript. Table 1044 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P3, HUMPFKJP4, HUMPFKJP5, HUMPFK_P6, HUMPFK_P7, HUMPFKJP8, HUMPFKJP9, HUMPFK_P10 and HUMPFK P13.

Segment cluster HUMPFK_node_44 according to the present invention is supported by 113 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_Tl 3, HUMPFK_T15, HUMPFK_T16, HUMPFK_Tl 8, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1045 below describes the starting and ending position of this segment on each transcript.

Table 1045 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFK_JP5, HUMPFK_P6, HUMPFKJP7, HUMPFK_P8, HUMPFK_P9, HUMPFK-PlO and HUMPFK_P13.

Segment cluster F£JMPFK_node_48 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T7 and HUMPFK_T13. Table 1046 below describes the starting and ending position of this segment on each transcript.

Table 1046 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P6.

Segment cluster HUMPFK_node_49 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T7 and HUMPFK_T13. Table 1047 below describes the starting and ending position of this segment on each transcript.

Table 1047 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJP6.

Segment cluster HUMPFK_node_54 according to the present invention is supported by

114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T16, HUMPFKJf 18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1048 below describes the starting and ending position of this segment on each transcript.

Table 1048 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1049.

Table 1049 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJP6. This segment can also be found in the following protein(s): HUMPFK_P3, HUMPFK_P4, HUMPFKJP5, HUMPFK_P7, HUMPFK_P8, HUMPFK_P9, HUMPFK_P10 and HUMPFK_P13, since it is in the coding region for the corresponding transcript. Segment cluster HUMPFK_node_57 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T 1, HUMPFKJ6, HUMPFK _TI l and HUMPFK_T14. Table 1050 below describes the starting and ending position of this segment on each transcript.

Table 1050 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1051.

Table 1051 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMPFK_P2.

Segment cluster HUMPFK_node_58 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK _Tl and HUMPFK_Tl 1. Table 1052 below describes the starting and ending position of this segment on each transcript. Table 1052 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2.

Segment cluster HUMPFK_node_59 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T6, HUMPFK _T7, HUMPFK_T8, HUMPFK_T11 and HUMPFK_T14. Table 1053 below describes the starting and ending position of this segment on each transcript.

Table 1053 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2 and HUMPFK_P6. This segment can also be found in the following protein(s): HUMPFKJP7, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_60 according to the present invention is supported by

18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK-Tl, HUMPFK _T6, HUMPFK_T7 and

HUMPFK_Tl 1. Table 1054 below describes the starting and ending position of this segment on each transcript.

Table 1054 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPFKJP2 and HUMPFK JP6.

Segment cluster HUMPFK_node_61 according to the present invention is supported by

15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK-Tl, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8, HUMPFK_Tl l and HUMPFK_T14. Table 1055 below describes the starting and ending position of this segment on each transcript. Table 1055 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2 and HUMPFK_P6. This segment can also be found in the following protein(s): HUMPFK_P7, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_62 according to the present invention is supported by

17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T6, HUMPFK_T7,

HUMPFK_T8, HJMPFK_Tl 1 and HUMPFK_T14. Table 1056 below describes the starting and ending position of this segment on each transcript. Table 1056 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFKJP6 and HUMPFK_P7.

Segment cluster HUMPFK_node_63 according to the present invention is supported by

13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T6, HUMPFK_T7,

HUMPFK_T8, HUMPFK-Tl 1 and HUMPFK_T14. Table 1057 below describes the starting and ending position of this segment on each transcript.

Table 1057 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFKJP6 and HUMPFKJP7.

Segment cluster HUMPFK_node_64 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8 and HUMPFK_T14. Table 1058 below describes the starting and ending position of this segment on each transcript.

Table 1058 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJP2, HUMPFKJP6 and HUMPFK_P7.

Segment cluster HUMPFK_node_65 according to the present invention is supported by 144 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFKJl, HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFKJ6, HUMPFKJ7, HUMPFK_T8, HUMPFK JI l, HUMPFKJ12, HUMPFK_T13, HUMPFKJ14, HUMPFK_T 15, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1059 below describes the starting and ending position of this segment on each transcript. Table 1059 - Segment location on ti"anscripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJP2, HUMPFKJP6 and HUMPFK_P7. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFKJP4, HUMPFK_P5, HUMPFKJP8, HUMPFK_P9, HUMPFK_P10 and HUMPFK Pl 3, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_83 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK T6, HUMPFK_T7, HUMPFK_T8, HUMPFK_Tll, HUMPFK_T12, HUMPFK_T13, HUMPFK_T14, HUMPFK_T15 and HUMPFK_T18. Table 1060 below describes the starting and ending position of this segment on each transcript. - - Table 1060 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFK_P3, HUMPFK_P4, HUMPFKJP5, HUMPFKJP6, HUMPFK_P7, HUMPFKJP8 and HUMPFK_P9.

Segment cluster HUMPFK_node_91 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T16, HUMPFK_T26, HUMPFK_T27, HUMPFK_T30 and HUMPFK_T45. Table 1061 below describes the starting and ending position of this segment on each transcript.

Table 1061 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJPl 0. This segment can also be found in the following protein(s): HUMPFK_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_93 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T16 and HUMPFK_T45. Table 1062 below describes the starting and ending position of this segment on each transcript.

Table 1062 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P10.

Segment cluster HUMPFK_node_99 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T26, HUMPFK_T27 and HUMPFKJBO. Table 1063 below describes the starting and ending position of this segment on each transcript.

Table 1063 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK P 10. This segment can also be found in the following protein(s): HUMPFK Pl 3, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_102 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1064 below describes the starting and ending position of this segment on each transcript.

Table 1064 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJP10 and HUMPFKJP13. Segment cluster HUMPFK_node_104 according to the present invention is supported by 1 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMPFK_T26, HUMPFK_T27 and HUMPFK._T30. Table 1065 below describes the starting and ending position of this segment on each transcript.

Table 1065 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P10 and HUMPFKJP13.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMPFK_node_3 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T5. Table 1066 below describes the starting and ending position of this segment on each transcript.

Table 1066 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P5.

Segment cluster HUMPFKjnode 6 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2 and HUMPFK_T5. Table 1067 below describes the starting and ending position of this segment on each transcript.

Table 1067 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P3. This segment can also be found in the following protein(s): HUMPFK_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_12 according to the present invention is supported by

55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T16, HUMPFK Tl 8, HUMPFK T26, HUMPFK_T27, HUMPFK T30, HUMPFK_T49 and HUMPFK_T50. Table 1068 below describes the starting and ending position of this segment on each transcript.

Table 1068 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P8 and HUMPFK_P9. This segment can also be found in the following protein(s): HUMPFK_P3, HUMPFKJP5, HUMPFK_P6, HUMPFKJP7, HUMPFK_P10, HUMPFK_P13, HUMPFKJP25 and HUMPFK_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_l 6 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5,

HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15,

HUMPFK_T16, HUMPFK_T18, HUMPFK T26, HUMPFK_T27, HUMPFK_T30,

HUMPFK_T49 and HUMPFK_T50. Table 1069 below describes the starting and ending position of this segment on each transcript.

Table 1069 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPFK P8 and HUMPFKJP9. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFK_P5, HUMPFK_P6, HUMPFKJP7, HUMPFK_P10, HUMPFK_P13, HUMPFK_P25 and HUMPFK_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_21 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T5. Table 1070 below describes the starting and ending position of this segment on each transcript.

Table 1070 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P5.

Segment cluster HUMPFK_node_28 according to the present invention is supported by 94 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFKJl 6, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1071 below describes the starting and ending position of this segment on each transcript.

Table 1071 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P9. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFKJP5, HUMPFKJP6, HUMPFK_P7, HUMPFKJP8, HUMPFK_P10 and HUMPFK_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_31 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15₅ HUMPFK_T16, HUMPFKJl 8, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1072 below describes the starting and ending position of this segment on each transcript. Table 1072 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFKJP5, HUMPFKJP6, HUMPFK_P7, HUMPFKJP8, HUMPFK_P9, HUMPFK_P10 and HUMPFK_P13.

Segment cluster HUMPFK_node_33 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK _T27 and HUMPFK_T30. Table 1073 below describes the starting and ending position of this segment on each transcript.

Table 1073 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFK_P5, HUMPFK_P6, HUMPFKJP7, HUMPFK_P8, HUMPFKJP9, HUMPFK_P10 and HUMPFK Pl 3.

Segment cluster HUMPFK_node_34 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_Tl 5, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1074 below describes the starting and ending position of this segment on each transcript.

Table 1074 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1075. Table 1075 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMPFK_P3, HUMPFK_P4, HUMPFK_P5, HUMPFKJP6, HUMPFKJP7, HUMPFK_P8, HUMPFKJP9, HUMPFKJP10 and HUMPFK_P13.

Segment cluster HUMPFKjriode_36 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK _T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK__T13, HUMPFK_Tl 5, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK T27 and HUMPFK_T30. Table 1076 below describes the starting and ending position of this segment on each transcript.

Table 1076 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1077. Table 1077 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMPFK_P3, HUMPFK_P4, HUMPFK_P5, HUMPFKJP6, HUMPFKJP7, HUMPFK_P8, HUMPFK_P9, HUMPFKJP 10 and HUMPFKJPl 3.

Segment cluster HUMPFK_node_40 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T 16, HUMPFK_Tl 8, HUMPFK _T26, HUMPFK_T27 and HUMPFK_T30. Table 1078 below describes the starting and ending position of this segment on each transcript.

Table 1078 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P3, HUMPFK_P4, HUMPFK_P5, HUMPFK_P6, HUMPFKJP7, HUMPFKJP8, HUMPFK_P9, HUMPFKJP 10 and HUMPFK P13.

Segment cluster HUMPFK_node_42 according to the present invention is supported by

103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1079 below describes the starting and ending position of this segment on each transcript.

Table 1079 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFKJP3, HUMPFKJP4, HUMPFK_P5, HUMPFK_P6, HUMPFK_P7, HUMPFK_P8, HUMPFK_P9, HUMPFK_P10 and HUMPFK P13.

Segment cluster HUMPFK_node_47 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T 12, HUMPFK_T13, HUMPFK_Tl 5, HUMPFK_Tl 6, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1080 below describes the starting and ending position of this segment on each transcript.

Table 1080 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P3, HUMPFK_P4, HUMPFK_P5, HUMPFK_P6, HUMPFK_P7, HUMPFK_P8, HUMPFKJP9, HUMPFK_P10 and HUMPFK_P13.

Segment cluster HUMPFK_node_50 according to the present invention can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1081 below describes the starting and ending position of this segment on each transcript.

Table 1081 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P6. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFKJP4, HUMPFKJP5, HUMPFK_P7, HUMPFKJP8, HUMPFK_P9, HUMPFK_P10 and HUMPFK_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_51 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7, HUMPFK_T8, HUMPFK__T12, HUMPFK_Tl 3, HUMPFK_Tl 5, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1082 below describes the starting and ending position of this segment on each transcript.

Table 1082 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P6. This segment can also be found in the following protein(s): HUMPFK_P3, HUMPFK_P4, HUMPFK_P5, HUMPFKJP7, HUMPFKJP8, HUMPFKJP9, HUMPFK_P10 and HUMPFK_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_53 according to the present invention can be found in the following transcript(s): HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T7,

HUMPFK_T8, HUMPFK_T12, HUMPFK_T13, HUMPFK_T15, HUMPFK_T16,

HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1083 below describes the starting and ending position of this segment on each transcript.

Table 1083 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P6. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFKJP4, HUMPFK_P5, HUMPFK_P7, HUMPFKJP8, HUMPFK_P9, HUMPFK_P10 and HUMPFK-Pl 3, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_67 according to the present invention is supported by 137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T1, HUMPFK_T2, HUMPFK_T4,

HUMPFK_T5, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8, HUMPFK-Tl 1, HUMPFK_Tl 2,

HUMPFK_T13, HUMPFK_T14, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18,

HUMPFK_T26, HUMPFKJ27 and HUMPFK_T30. Table 1084 below describes the starting and ending position of this segment on each transcript.

Table 1084 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFK_P6 and HUMPFK_P7. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFKJM, HUMPFK_P5, HUMPFKJP8, HUMPFKJP9, HUMPFK_P10 and HUMPFKJP 13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_69 according to the present invention is supported by 175 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T2, HUMPFK_T4,

HUMPFK_T5, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8, HUMPFK_Tl l, HUMPFK_Tl 2,

HUMPFK _T13, HUMPFK_T14, HUMPFK _T15, HUMPFK _T16, HUMPFK _T18,

HUMPFK _T26, HUMPFK _T27 and HUMPFK_T30. Table 1085 below describes the starting and ending positio n of this segment on each transcript.

Table 1085 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFK_P6 and HUMPFK_P7. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFKJM, HUMPFKJP5, HUMPFKJP8, HUMPFKJP9, HUMPFKJPIO and HUMPFKJPl 3, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_73 according to the present invention is supported by 150 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T2, HUMPFK_T4,

HUMPFK_T5, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8, HUMPFK_T11, HUMPFKJ12,

HUMPFK_T13, HUMPFK_T14, HUMPFK_T15, HUMPFK_T16₅ HUMPFK_T18,

HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1086 below describes the starting and ending position of this segment on each transcript.

Table 1086 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFK_P6 and HUMPFK_P7. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFK_P5, HUMPFK_P8, HUMPFK JP9, HUMPFK_P10 and HUMPFK_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_74 according to the present invention is supported by 159 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK J¹I, HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8, HUMPFK_T11, HUMPFKJ12, HUMPFKJ13, HUMPFK_T14, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1087 below describes the starting and ending position of this segment on each transcript.

Table 1087 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFK_P6 and HUMPFK_P7. This segment can also be found in the following protein(s): HUMPFKJP3, HUMPFK_P4, HUMPFKJP5, HUMPFKJP8, HUMPFKJP9, HUMPFK_P10 and HUMPFK_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_78 according to the present invention is supported by 155 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T2, HUMPFK_T4,

HUMPFK_T5, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8, HUMPFK_Tl l, HUMPFK_T12,

HUMPFK_T13, HUMPFK_T14, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18,

HUMPFK_T26, HUMPFK_T27 and HUMPFK_T30. Table 1088 below describes the starting and ending position of this segment on each transcript.

Table 1088 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1089.

Table 1089 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJP2, HUMPFKJP6 and HUMPFK_P7. This segment can also be found in the following protein(s): HUMPFK_P3, HUMPFKJP4, HUMPFK_P5, HUMPFK_P8, HUMPFKJP9, HUMPFK_P10 and FTUMPFKJP13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_79 according to the present invention can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8, HUMPFK-TI l, HUMPFK_T12, HUMPFK_T13, HUMPFK_T14, HUMPFK_T15, HUMPFK_T16, HUMPFK_T18, HUMPFK_T26, HUMPFK _T27 and HUMPFK _T30. Table 1090 below describes the starting and ending position of this segment on each transcript.

Table 1090 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1091.

Table 1091 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): HUMPFK_P2, HUMPFK_P6 and HUMPFK_P7. This segment can also be found in the following protein(s): HUMPFK_P3, HUMPFK_P4, HUMPFKJP5, HUMPFKJP8, HUMPFKJP9, HUMPFK_P10 and HUMPFK_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_81 according to the present invention is supported by

137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFK_T6, HUMPFK_T7, HUMPFK_T8, HUMPFK_T11, HUMPFK_Tl 2, HUMPFK_T13, HUMPFK_T14, HUMPFK_T15 and HUMPFK_T18. Table 1092 below describes the starting and ending position of this segment on each transcript.

Table 1092 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFK_P6 and HUMPFK_P7. This segment can also be found in the following protein(s): HUMPFK_P3, HUMPFK_P4, HUMPFK_P5, HUMPFKJP8 and HUMPFK_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_82 according to the present invention is supported by 133 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_Tl, HUMPFK_T2, HUMPFK_T4, HUMPFK_T5, HUMPFKJ6, HUMPFK_T7, HUMPFK_T8, HUMPFK-Tl 1, HUMPFK_T12, HUMPFK_T13, HUMPFK _T14, HUMPFK_T15 and HUMPFK_T18. Table 1093 below describes the starting and ending position of this segment on each transcript.

Table 1093 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFK_P2, HUMPFK_P6 and HUMPFKJP7. This segment can also be found in the following protein(s): HUMPFK_P3, HUMPFKJP4, HUMPFK_P5, HUMPFK_P8 and HUMPFK_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPFK_node_87 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HUMPFK_T45. Table 1094 below describes the starting and ending position of this segment on each transcript.

Table 1094 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMPFK_node_89 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPFK_T16, HUMPFK_T26 and HUMPFK_T45. Table 1095 below describes the starting and ending position of this segment on each transcript.

Table 1095 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPFK_P10.

Segment cluster HUMPFK_node_101 according to the present invention can be found in the following transcript(s): HUMPFK_T30. Table 1096 below describes the starting and ending position of this segment on each transcript. Table 1096 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPFKJP13.

Segment cluster HUMPFK_node_103 according to the present invention can be found in the following transcript(s): HUMPFK_T26 and HUMPFKJ27. Table 1097 below describes the starting and ending position of this segment on each transcript.

Table 1097 ^' - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPFKJP10 and HUMPFK_P13. DESCRIPTION FOR CLUSTER HUMPRPOA

Cluster HUMPRPOA features 3 transcript(s) and 30 segment(s) of interest, the names for which are given in Tables 1098 and 1099, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1100.

Table 1098 - Transcripts of interest

TranscriptName '

HUMPRPOA T3

HUMPRPOA T4

HUMPRPOA T5

Table 1099 - Segments of interest

Segment Name -

HUMPRPOA node 5

HUMPRPOA node 1

HUMPRPOA node 9

HUMPRPOA node 33

HUMPRPOA node 35

HUMPRPOA node 37

HUMPRPOA node 11

HUMPRPOA node 12

HUMPRPOA node 13

HUMPRPOA node 14

HUMPRPOA node 15

HUMPRPOA node 16

HUMPRPOA node 17

HUMPRPOA node 18

HUMPRPOA node 19

HUMPRPOA node 20

HUMPRPOA node 21

HUMPRPOA node 22

HUMPRPOA node 23

HUMPRPOA node 24

HUMPRPOA node 25

HUMPRPOA node 26

HUMPRPOA node 27

HUMPRPOA node 28 HUMPRPOA node 29

HUMPRPOA node 30

HUMPRPOA node 31

HUMPRPOA node 32

HUMPRPOA node 34

HUMPRPOA node 36

Table 1100 - Proteins of interest

These sequences are variants of the known protein Major prion protein precursor (SwissProt accession identifier PRIO-HUMAN; known also according to the synonyms PrP; PrP27-30; PrP33-35C; ASCR; CD230 antigen), referred to herein as the previously known protein.

Protein Major prion protein precursor is known or believed to have the following function(s): The physiological function of PrP is not known. The sequence for protein Major prion protein precursor is given at the end of the application, as "Major prion protein precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 1101.

Table 1101 -Amino acid mutations for Known Protein

Protein Major prion protein precursor localization is believed to be Attached to the membrane by a GPI-anchor.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: metabolism, which are annotation(s) related to Biological Process.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nrm.nih.gov/projects/LocusLink/>.

Cluster HUMPRPOA can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 29 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 29 and Table 1102. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: malignant tumors involving the lymph nodes.

Table 1102 - Normal tissue distribution

Table 1103 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMPRPOA features 30 segment(s), which were listed in Table

1099 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMPRP0A_node_5 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T4 and HUMPRP0A_T5. Table 1104 below describes the starting and ending position of this segment on each transcript.

Table 1104 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPRP0A_Pl. Segment cluster HUMPRJP0A_node_7 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T5. Table 1105 below describes the starting and ending position of this segment on each transcript.

Table 1105 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_9 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3. Table 1106 below describes the starting and ending position of this segment on each transcript.

Table 1106 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_33 according to the present invention is supported by 430 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and

HUMPRP0A__T5. Table 1107 below describes the starting and ending position of this segment on each transcript.

Table 1107 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOA_P1.

Segment cluster HUMPRP0A_node_35 according to the present invention is supported by 356 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1108 below describes the starting and ending position of this segment on each transcript

Table 1108 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPRPOA_P1.

Segment cluster HUMPRPO A_node_37 according to the present invention is supported by 309 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRPO A_T5. Table 1109 below describes the starting and ending position of this segment on each transcript.

Table 1109 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPRPOAJ⁵! .

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMPRP0A_node_l 1 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1110 below describes the starting and ending position of this segment on each transcript.

Table 1110 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_P 1.

Segment cluster HUMPRP0A_node_12 according to the present invention is supported by 141 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRPO A T5. Table 1111 below describes the starting and ending position of this segment on each transcript.

Table 1111 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl. Segment cluster HUMPRP0A_node_13 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRPO A_T5. Table 1112 below describes the starting and ending position of this segment on each transcript.

Table 1112 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_14 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1113 below describes the starting and ending position of this segment on each transcript.

Table 1113 - Segment location on transcripts — - _ - _ .

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_15 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1114 below describes the starting and ending position of this segment on each transcript. Table 1114 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOA_P1.

Segment cluster HUMPRP0A_node_16 according to the present invention is supported by 145 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A T5. Table 1115 below describes the starting and ending position of this segment on each transcript.

Table 1115 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_17 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1116 below describes the starting and ending position of this segment on each transcript.

Table 1116 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_18 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1117 below describes the starting and ending position of this segment on each transcript. Table 1117 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_19 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1118 below describes the starting and ending position of this segment on each transcript.

Table 1118 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_20 according to the present invention is supported by

140 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1119 below describes the starting and ending position of this segment on each transcript.

Table 1119 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOA_P1. Segment cluster HUMPRP0A_node_21 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1120 below describes the starting and ending position of this segment on each transcript. Table 1120 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOAJPl.

Segment cluster HUMPRP0A_node_22 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A T5. Table 1121 below describes the starting and ending position of this segment on each transcript.

Table 1121 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOAJPl.

Segment cluster HUMPRP0A_node_23 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1122 below describes the starting and ending position of this segment on each transcript.

Table 1122 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOA_P1.

Segment cluster HUMPRP0A_node_24 according to the present invention is supported by 117 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRPO A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1123 below describes the starting and ending position of this segment on each transcript.

Table 1123 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOAJPl.

Segment cluster HUMPRP0A_node_25 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1124 below describes the starting and ending position of this segment on e ach transcript.

Table 1124 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOA_P1.

Segment cluster HUMPRP0A_node_26 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1125 below describes the starting and ending position of this segment on each transcript.

Table 1125 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_27 according to the present invention is supported by 128 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1126 below describes the starting and ending position of this segment on each transcript.

Table 1126 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_28 according to the present invention is supported by 132 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRPO A T5. Table 1127 below describes the starting and ending position of this segment on each transcript.

Table 1127 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRPOA__P1. Segment cluster HUMPRP0A_node_29 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1128 below describes the starting and ending position of this segment on each transcript. Table 1128 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_P 1.

Segment cluster HUMPRPO A_node_30 according to the present invention is supported by 144 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A T4 and HUMPRP0A_T5. Table 1129 below describes the starting and ending position of this segment on each transcript.

Table 1129 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_node_31 according to the present invention is supported by

147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and

HUMPRP0A_T5. Table 1130 below describes the starting and ending position of this segment on each transcript.

Table 1130 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRPO A_node_32 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRPO A_T5. Table 1131 below describes the starting and ending position of this segment on each transcript.

Table 1131 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPRP0A_Pl.

Segment cluster HUMPRP0A_nodeJ34 according to the present invention can be found in the following transcript(s): HUMPRP0A_T3, HUMPRP0A_T4 and HUMPRP0A_T5. Table 1132 below describes the starting and ending position of this segment on each transcript.

Table 1132 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPRP0A_Pl. Segment cluster HUMPRPO A_node_36 according to the present invention is supported by 258 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPRPO A_T3, HUMPRP0A_T4 and HUMPRPO A_T5. Table 1133 below describes the starting and ending position of this segment on each transcript.

Table 1133 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPRP0A_Pl.

DESCRIPTION FOR CLUSTER HUMTIAlE

Cluster HUMTIAlE features 41 transcript(s) and 46 segment(s) of interest, the names for which are given in Tables 1134 and 1135, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1136.

Table 1134 - Transcripts of interest

Transcript Name

HUMTIAlE TO

HUMTIAlE Tl

HUMTIAlE T2

HUMTIAlE T3

HUMTIA1E_ _T6

HUMTIAlE T8

HUMTIAlE T9

HUMTIAlE TlO

HUMTLAlE TI l

HUMTIAlE T12

HUMTIAlE T13

HUMTIAlE T14 HUMTIAlE T15

HUMTIAlE T16

HUMTIAlE T17

HUMTIAlE T18

HUMTIAlE T19

HUMTIAlE T20

HUMTIAlE T21

HUMTIAlE T22

HUMTIAlE T23

HUMTIA1E_ T24

HUMTIAlE T26

HUMTIAlE T27

HUMTIAlE T28

HUMTIAlE T29

HUMTIAlE T32

HUMTIAlE T37

HUMTIAlE T40

HUMTIAlE T45

HUMTIAlE T46

HUMTIAlE T47

HUMTIAlE T48

HUMTIAlE T50

HUMTIAlE T51

HUMTIAlE T52

HUMTIAlE T55

HUMTIAlE T56

HUMTIAlE T57

HUMTIAlE T58

HUMTIAlE T60

Table 1135 - Segments of interest

Segment Name

HUMTIAlE node 14

HUMTIAlE node 16

HUMTIAlE node 18

HUMTIAlE node 20

HUMTIAlE node 22

HUMTIAlE node 23

HUMTIAlE node 25

HUMTIAlE node 27

HUMTIAlE node 30

HUMTIAlE node 33

HUMTIAlE node 36 HUMTIAlE node 45

HUMTIAlE node 46

HUMTIAlE node 50

HUMTIAlE node 51

HUMTIAlE node 52

HUMTIAlE node 54

HUMTIAlE node 55

HUMTIAlE node 57

HUMTIAlE node 59

HUMTIA1E_ node .0

HUMTIAlE node 1

HUMTIAlE node 2

HUMTIAlE node 3

HUMTIAlE node 5

HUMTIAlE node 6

HUMTLAlE node 7

HUMTIAlE node 10

HUMTIAlE node 11

HUMTIAlE node 12

HUMTIAlE node 15

HUMTIAlE node 17

HUMTIAlE node 19

HUMTLAlE node 21

HUMTIAlE node 24

HUMTIAlE node 26

HUMTIA1E_ node 28

HUMTIAlE node 29

HUMTIAlE node 35

HUMTIAlE node 43

HUMTIAlE node 44

HUMTIAlE node 47

HUMTIAlE node 48

HUMTIAlE node 49

HUMTIAlE node 53

HUMTIAlE node 58

Table 1136 - Proteins of interest

Protein Name Corresponding Transcript(s)

HUMTIAlE Pl HUMTIAlE TO; HUMTIAlE Tl;

HUMTIAlE T3; HUMTIAlE T6;

HUMTLAlE TlO; HUMTIAlE T14;

HUMTIAlE T15; HUMTIAlE Tl 6;

HUMTIAlE T17; HUMTLAlE T21;

These sequences are variants of the known protein Nucleolysin TIA-I (SwissProt accession identifier TIA1_HUMAN; known also according to the synonyms RNA-binding protein TIA-I; P40-TIA-1), referred to herein as the previously known protein.

Protein Nucleolysin TIA-I is known or believed to have the following function(s): RNA- binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. The sequence for protein Nucleolysin TIA-I is given at the end of the application, as "Nucleolysin TIA-I amino acid sequence". Protein Nucleolysin TIA-I localization is believed to be Cytoplasmic granules of cytolytic T- lymphocytes.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: apoptosis; induction of apoptosis, which are annotation(s) related to Biological Process; and nucleic acid binding; RNA binding; poly(A) binding, which are annotation(s) related to Molecular Function.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>. Cluster HUMTIAlE can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 30 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 30 and Table 1137. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: lung malignant tumors. 30

Table 1137 - Normal tissue distribution

Table 1138 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMTIAlE features 46 segment(s), which were listed in Table

1135 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMTIA lE_node_ 14 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T15. Table 1139 below describes the starting and ending position of this segment on each transcript.

Table 1139 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTIA IEJPl.

Segment cluster HUMTIA lE_node_l 6 according to the present invention is supported by

4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T3, HUMTIA1E_T15 and HUMTIA1E_T17. Table 1140 below describes the starting and ending position of this segment on each transcript. Table 1140 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA 1 E_P 1.

Segment cluster HUMTIA lE_node_l 8 according to the present invention is supported by

16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIAIE_TO, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T11, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T23, HUMTIA1E_T24, HUMTLA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T50, HUMTIA1E_T51, HUMTIA1E_T52 and HUMTIA1E_T56. Table 1141 bebw describes the starting and ending position of this segment on each transcript. Table 1141 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAl EJPl, HUMTIA1EJP2, HUMTIA1EJP6 and HUMTIA1EJP8. This segment can also be found in the following protein(s): HUMTIA1EJP5, since it is in the coding region for the corresponding transcript. Segment cluster HUMTIA 1 E_node_20 according to the present invention is supported by

19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T0, HJMTIA1E_T2, HUMTIA1E_T3,

HUMTIA 1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T11, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17,

HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T23,

HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T40,

HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T5O,

HUMTIA1E_T51, HUMTIA1E_T52 and HUMTIA1E_T56. Table 1142 below describes the starting and ending position of this segment on each transcript.

Table 1142 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAIEJPI, HUMTIA1EJP2, HUMTIA 1E_P5, HUMTIA1E_P6 and HUMTIAlE P8.

Segment cluster HUMTIA lE_node_22 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIAIE_TO, HUMTIA1E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T10, HUMTIAlE_Tl l, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T26, HUMTIA1E_T28, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E T47, HUMTIA1E_T48, HUMTIA1E_T5O, HUMTIAl E_T51 and HUMTIA1E T52. Table 1143 below describes the starting and ending position of this segment on each transcript.

Table 1143 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMIlAlE-P 1, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1E_P6 and HUMTIAlE P8.

Segment cluster HUMTIA lE_node_23 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIAIE_TO, HUMTIAl E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAlE_T10, HUMTIAlEjril, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTΪA1E_T17, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T28, HUMTIA1E_T40, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIAlE _T50, HUMTIA1E_T51 and HUMTIA1E_T52. Table 1144 below describes the starting and ending position of this segment on each transcript.

Table 1144 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAlE-P 1, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1EJP6 and HUMTIAlE P8.

Segment cluster HUMTIAlE__node_25 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIAIE_TI, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAIE_TIO, HUMTIAl E_T11 , HUMTIA 1E_T 12, HUMTIAl E_T13, HUMTIA IE_T 14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA 1E_T28, HUMTIA1E_T40, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T5O, HUMTIA1E_T51 and HUMTIA 1E_T52. Table 1145 below describes the starting and ending position of this segment on each transcript.

Table 1145 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA 1E_P1, HUMTIA1E_P2, HUMTIA1EJP5 and HUMTIA1E_P8.

Segment cluster HUMTIAlE_node_27 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIAIE_TO, HUMTIA IE_Tl, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T10, HUMTIAlEjπ i, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T28, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIAlE_T50, HUMTIA1E_T51 and HUMTIA 1E_T52. Table 1146 below describes the starting and ending position of this segment on each transcript.

Table 1146 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1EJP2 and HUMTIA1E_P5. This segment can also be found in the following protein(s): HUMTIA1E_P1 and HUMTIA1E_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_30 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA1E_T58. Table 1147 below describes the starting and ending position of this segment on each transcript.

Table 1147 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5 and HUMTIA1E_P15. This segment can also be found in the following protein(s): HUMTIA1E_P14, since it is in the coding region for the corresponding transcript. Segment cluster HUMTIA lE_node_33 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA 1E_T6O. Table 1148 below describes the starting and ending position of this segment on each transcript.

Table 1148 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P16.

Segment cluster HUMTIA lE_node_36 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T51 and HUMTIA1E_T60. Table 1149 below describes the starting and ending position of this segment on each transcript.

Table 1149 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA 1E_P5. This segment can also be found in the following protein(s): HUMTIAIE-PIO, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_45 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T2, HUMTIA1E_T9, HUMTIA1E_T11, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T2O, HUMTIA1E_T23, HUMTIA1E_T26, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIAlE_T50 and HUMTIA1E_T55. Table 1150 below describes the starting and ending position of this segment on each transcript.

Table 1150 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P2 and HUMTIA1E_P5. This segment can also be found in the following protein(s): HUMTIA1E_P7 and HUMTIA1E_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_46 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T9. Table 1151 below describes the starting and ending position of this segment on each transcript. Table 1151 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5. Segment cluster HUMTIA lE_node_50 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T12, HUMTIA IE_Tl 3, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T50 and HUMTIA1E_T55. Table 1152 below describes the starting and ending position of this segment on each transcript.

Table 1152 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5, HUMTIA1E_P7 and HUMTIA1E_P9.

Segment cluster HUMTIA lE_node_51 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIA1E T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAlE_T10, HUMTΪAlE_Tll, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47 and HUMTIA1E_T48. Table 1153 below describes the starting and ending position of this segment on each transcript.

Table 1153 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5, HUMTIA1E_P7 and HUMTIA1E_P9. This segment can also be found in the following protein(s): HUMTIA1E_P1, HUMTIA1E_P2, HUMTIA1E_P6 and HUMTIA1E_P8, since it is in the coding region for the corresponding transcript. Segment cluster HUMTIA lE_node_52 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA 1E_T23. Table 1154 below describes the starting and ending position of this segment on each transcript.

Table 1154 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5.

Segment cluster HUMTIAlE_node_54 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T23. Table 1155 below describes the starting and ending position of this segment on each transcript. Table 1155 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5.

Segment cluster HUMTIAlEjnode_55 according to the present invention is supported by

88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMIlAl E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAlE_T10, HUMTIAlE_Tl l, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47 and HUMTIA1E_T48. Table 1156 below describes the starting and ending position of this segment on each transcript.

Table 1156 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5, HUMTIA1E_P8, HUMTIA1E_P7 and HUMTIA1E_P9. This segment can also be found in the following protein(s): HUMTIA IEJP I₅ HUMTIA1E_P2 and HUMTIA 1EJP6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_57 according to the present invention is supported by 153 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIA IEJN, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAIE_TIO, HUMTIA1E_T11, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1EJN5, HUMTIA1E T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1EJN9, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47 and HUMTIA1E_T48. Table 1157 below describes the starting and ending position of this segment on each transcript.

Table 1157 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5, HUMTIA1E_P8, HUMTIA1E_P7 and HUMTIA1E_P9. This segment can also be found in the following protein(s): HUMTIA1EJP1, HUMTIA1EJP2 and HUMTIA1E_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_59 according to the present invention is supported by 381 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript®: HUMTIA1E_TO, HUMTIAIE_TI, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T1O, HUMTIAlE_Tll, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E__T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47 and HUMTIA1E_T48. Table 1158 below describes the starting and ending position of this segment on each transcript. Table 1158 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P1, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1E_P6, HUMTIA1E_P8, HUMTIA1E_P7 and HUMTIA1E_P9. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMTIA lE_nodeJ3 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA 1E_TO, HUMTIAIE_TI, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAIE_TIO, HUMTIAlEjπ i, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T16, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIAlE_T50, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA1E_T58. Table 1159 below describes the starting and ending position of this segment on each transcript.

Table 1159 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMITA IEJPl, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1E_P6, HUMTIA1E_P8, HUMTIA1E_P7, HUMTIA1EJP9, HUMTIA1EJP15 and HUMTIA1EJP14.

Segment cluster HUMTIA lE_node_l according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTLA1E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T1O, HUMTIAlEjπi, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T16, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIAlE_T40, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T5O, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA 1E_T58. Table 1160 below describes the starting and ending position of this segment on each transcript.

Table 1160 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTIAl EJPl, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1E_P6, HUMTIAlE J^>8, HUMTIA1E_P7, HUMTIA1E_P9, HUMTIAlE Pl 5 and HUMTIAlE P14.

Segment cluster HUMTIA lE_node_2 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIA1E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T10, HUMTIAlEjri l, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T16, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMΗA1E_T47, HUMTIA1E_T48, HUMTIAlE_T50, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA1E_T58. Table 1161 below describes the starting and ending position of this segment on each transcript.

Table 1161 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P1, HUMTIA1EJP2, HUMTIA1E_P5, HUMTIA1E_P6, HUMTIA1E_P8, HUMTIA1E_P7, HUMTIA1E_P9, HUMTIA1E_P15 and HUMTIA1E_P14.

Segment cluster HUMTIA lE_node_3 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIAIE_TI, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T1O, HUMTIAlEjri l, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T16, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T50, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA 1E_T58. Table 1162 below describes the starting and ending position of this segment on each transcript.

Table 1162 - Segment location on transcripts

I HUMTIA1E T58 [ 239 |_313 |

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA 1E_P1, HUMTIA 1E_P2, HUMTIA1E_P6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1EJP5, HUMTIA 1EJP7, HUMTIA1E_P9, HUMTIA1E_P15 and HUMTIA1E_P14, since it is in the coding region fir the corresponding transcript.

Segment cluster HUMTIAl E_node_5 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLA1E__T17. Table 1163 below describes the starting and ending position of this segment on each transcript.

Table 1163 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P1.

Segment cluster HUMTIA lE_node_6 according to the present invention can be found in the following transcript(s): HUMTIA1E_TO, HUMTIA1E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAlE_T10, HUMTIAlE_Tll, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIA1E_T23, HUMTIA1E_T24, HUMTLA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T50, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA1E_T58. Table 1164 below describes the starting and ending position of this segment on each transcript.

Table 1164 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P1, HUMTIA1E_P2, HUMTIA1E_P6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1E_P5, HUMTIA 1E_P7, HUMTIA1E_P9, HUMTIA 1E_P 15 and HUMTIA1E_P14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_7 according to the present invention is supported by

53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T0, HUMTIAIE_TI, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAIE_TIO, HUMTIAlEjπ i, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIAl E_T47, HUMTIA1E_T48, HUMTIA1E_T5O, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA 1E_T58. Table 1165 below describes the starting and ending position of this segment on each transcript.

Table 1165 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1EJP1, HUMTIA1E_P2, HUMTIA1E_P6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1E_P5, HUMTIA1E_P7, HUMTIA1EJP9, HUMTIA1EJP15 and HUMTIA1E_P14, since it s in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_10 according to the present invention can be found in the following transcript(s): HUMTIA1E_TO, HUMTIAIE_TI, HUMTIA1E_T2,

HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIAl E_T9, HUMTIAIE_TIO,

HUMTIAlEjπ i, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T16,

HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21,

HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T40,

HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIAlE_T50,

HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA 1E_T58. Table 1166 below describes the starting and ending position of this segment on each transcript.

Table 1166 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAl EJU, HUMTIA1E_P2, HUMTIA1EJP6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1E_P5, HUMTIA1EJP7, HUMTIA1E_P9, HUMTIA1E_P15 and HUMTIA1EJP14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIAlE_node_l 1 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIA1E_T1, HUMTIA1E_T2,

HUMTIA1E T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAIE_TIO,

HUMTIAlEjπi, HUMTIA1E_T12₅ HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T16,

HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27,

HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E T37, HUMTIA1E_T4O,

HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIAlE_T50,

HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA1E_T58. Table 1167 below describes the starting and ending position of this segment on each transcript.

Table 1167 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAl EJPl, HUMTIA1E_P2, HUMTIA1EJP6 and HUMTIA1EJP8. This segment can also be found in the following protein(s): HUMTIA1E_P5, HUMTIA1EJP7, HUMTIA1EJP9, HUMTIA1EJP15 and HUMTIA1EJP14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIAlE_node_12 according to the present invention can be found in the following transcript(s): HUMTIA1E_T0, HUMTIA1E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T1O, HUMTIA1E_T11, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA 1E_T 14, HUMTIA 1E_T 16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T5O, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E__T57 and HUMTIA1E_T58. Table 1168 below describes the starting and ending position of this segment on each transcript.

Table 1168 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following piOtein(s): HUMTIA1E_P1, HUMTIA1E_P2, HUMTIA1E_P6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1E_P5, HUMTIA1E_P7, HUMTIA1E_P9, HUMTIA1E_P15 and HUMTIA1E_P14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIAlE_node_15 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIAIE_TO, HUMTIA1E_T1, HUMTIA1E_T2,

HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAlE_T10,

HUMTIAlE_Tl l, HUMTIA1E T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15,

HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26,

HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37,

HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48,

HUMTIAlE_T50, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56,

HUMTIA1E_T57 and HUMTIA1E_T58. Table 1169 below describes the starting and ending position of this segment on each transcript.

Table 1169 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P1, HUMTIA1E_P2, HUMTIA1E_P6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1EJP5, HUMTIA1E_P7, HUMTIA1E_P9, HUMTIA1EJP15 and HUMTIA 1E_P 14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_l 7 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIAIE_TO, HUMTIAIE_TI, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAlE_Tl l, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA 1E__T 14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T50, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56 and HUMTIA1E_T57. Table 1170 below describes the starting and ending position of this segment on each transcript.

Table 1170 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTIA1EJP1, HUMTIA1E P2, HUMTIA1E_P6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1E_P5, HUMTIA1E_P7 and HUMTIA1E P15, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIAlE_node_19 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T0, HUMTIAIE_TI, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T11, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T5O, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T56 and HUMTIA1E_T57. Table 1171 bebw describes the starting and ending position of this segment on each transcript.

Table 1171 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAIEJPI, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1E_P6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1EJP15, since it is in the coding region for the corresponding transcript. Segment cluster HUMTIA lE_node_21 according to the present invention is supported by 56 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T0, HUMTIAIE_TI, HUMTIA 1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T10, HUMTIAlE_Tl l, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIAl E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIAl E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T40, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIAlE_T50, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA1E_T58. Table 1172 below describes the starting and ending position of this segment on each transcript.

Table 1172 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAIEJPI, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIAl E_P6 and HUMTIA1E_P8. This segment can also be found in the following protein(s): HUMTIA1E_P7, HUMTIA1EJP9, HUMTIA1E_P15 and HUMTIA1E_P14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIAlE_node_24 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMIlAlE-T 1, HUMTIA1E_T2,

HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIAl E_T9, HUMTIAlE_T10,

HUMTIAlEjril, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15,

HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIAlEjm, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27,

HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46,

HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T50, HUMTIA1E_T51 and HUMTIA 1E_T52. Table 1173 below describes the starting and ending position of this segment on each transcript.

Table 1173 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAlE-P 1, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1E_P6 and HUMTIAlE P8.

Segment cluster HUMTIA lE_node_26 according to the present invention is supported by

13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIAIE_TI , HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAIE_TIO, HUMTIAlEjπi, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIAl E_T28, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T5O, HUMTIAl E_T51 and HUMTIA1E_T52. Table 1174 below describes the starting and ending position of this segment on each transcript. Table 1174 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTIAl EJPl, HUMTIA1EJP2, HUMTIA1EJP5 and HUMTIA1EJP8.

Segment cluster HUMTIA lE_node_28 according to the present invention is supported by

73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIA 1E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T10, HUMTIAlE_Tll, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T40, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T50, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T55, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA1E_T58. Table 1175 below describes the starting and ending position of this segment on each transcript.

Table 1175 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P2, HUMTIA1E_P5 and HUMTIA1E_P15. This segment can also be found in the following protein(s): HUMTIA1E_P1, HUMTIA1E_P6, HUMTIA1E_P8, HUMTIA1E_P7, HUMTIA1E_P9 and HUMTIA IEJ? 14, since it is in the coding region for the corresponding transcript. Segment cluster HUMTIA lE_node_29 according to the present invention can be found in the following transcript(s): HUMTIA1E_T8, HUMTIA1E_T51, HUMTIA1E_T52, HUMTIA1E_T56, HUMTIA1E_T57 and HUMTIA1E_T58. Table 1176 below describes the starting and ending position of this segment on each transcript.

Table 1176 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P2, HUMTIA1EJP5 and HUMTIA1E_P15. This segment can also be found in the following protein(s): HUMTIA1E_P14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_35 according to the present invention can be found in the following tanscript(s): HUMTIA1E_T51. Table 1177 below describes the starting and ending position of this segment on each transcript.

Table 1177 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5.

Segment cluster HUMTIA lE_node_43 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA IE_TO, HUMTIA IE_Tl, HUMTIA 1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T9, HUMTIAIE_TIO, HUMTIA1E_T11, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E__T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA 1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T50 and HUMTIA1E_T55. Table 1178 below describes the starting and ending position of this segment on each transcript.

Table 1178 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIAl E_P2 and HUMTIA1E_P5. This segment can also be found in the following protein(s): HUMTIA1E_P1, HUMTIA1E_P6, HUMTIA1E_P8, HUMTIA1EJP7 and HUMTIA1E_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_44 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIAl E_T1, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E T8, HUMTIA1E_T9, HUMTIA1E_T10, HUMTIAlE_Tl l, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTΪA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIAlE_T50 and HUMTIA1E_T55. Table 1179 below describes the starting and ending position of this segment on each transcript.

Table 1179 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P2 and HUMTIA1EJP5. This segment can also be found in the following protein(s): HUMΗAIEJPI, HUMTIA1E_P6, HUMTIA1E_P8, HUMTIA1E_P7 and HUMTIA1E_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_47 according to the present invention is supported by

66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIAIEJTO, HUMTIAIE_TI, HUMTIA1E_T2,

HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T10,

HUMTIAlEjril, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA 1E_T 16, HUMTIA1E_T17, HUMTIA IE_Tl 8, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26, HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T4O, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA1E_T50 and HUMTIA1E_T55. Table 1180 below describes the starting and ending position of this segment on each transcript.

Table 1180 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1E_P7 and HUMTIA1E_P9. This segment can also be found in the following protein(s): HUMTIA1EJP1, HUMTIA1E_P6 and HUMTIA1E_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIAlE_node_48 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIAl E_T 11 and HUMTIA1E_T13. Table 1181 below describes the starting and ending position of this segment on each transcript.

Table 1181 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P2 and HUMTIA1E_P5.

Segment cluster HUMTIA lE_node_49 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIAIE_TI, HUMTIA1E_T2, HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIAIE_TIO, HUMTIAlEjril, HUMTIA1E_T12, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15, HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T2O, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26₅ HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T40, HUMTIA1E_T45, HUMTIA1E_T46, HUMTIA1E_T47, HUMTIA1E_T48, HUMTIA 1E_T5O and HUMTIAl E_T55. Table 1182 below describes the starting and ending position of this segment on each transcript.

Table 1182 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcnpt(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1EJP5, HUMTIA1E_P7 and HUMTIA 1E P9. This segment can also be found in the following protein(s): HUMTIA1EJP1, HUMTIA1E_P2, HUMTIA1E_P6 and HUMTIA 1E_P 8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_53 according to the present invention is supported by

8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_T23, HUMTIA1E_T26 and HUMTIA 1E_T28. Table 1183 below describes the starting and ending position of this segment on each transcript.

Table 1183 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P5. This segment can also be found in the following protein(s): HUMTIA1E_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTIA lE_node_58 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTIA1E_TO, HUMTIA1E_T1, HUMTIA1E_T2,

HUMTIA1E_T3, HUMTIA1E_T6, HUMTIA1E_T8, HUMTIA1E_T9, HUMTIA1E_T10,

HUMTIAlE_Tl l, HUMTIAlEjm, HUMTIA1E_T13, HUMTIA1E_T14, HUMTIA1E_T15,

HUMTIA1E_T16, HUMTIA1E_T17, HUMTIA1E_T18, HUMTIA1E_T19, HUMTIA1E_T20, HUMTIA1E_T21, HUMTIA1E_T22, HUMTIA1E_T23, HUMTIA1E_T24, HUMTIA1E_T26,

HUMTIA1E_T27, HUMTIA1E_T28, HUMTIA1E_T29, HUMTIA1E_T32, HUMTIA1E_T37, HUMTIA1E_T45, HUMTIAl E_T46, HUMTIA 1E_T47 and HUMTIA1E_T48. Table 1 184 below describes the starting and ending position of this segment on each transcript.

Table 1184 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTIA1E_P1, HUMTIA1E_P2, HUMTIA1E_P5, HUMTIA1E_P6, HUMTIA1E_P8, HUMTIA1E_P7 and HUMTIA1EJP9. DESCRIPTION FOR CLUSTER M62239

Cluster M62239 features 6 transcript(s) and 23 segment(s) of interest, the names for which are given in Tables 1185 and 1186, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1187.

Table 1185 - Transcripts of interest

Transcript Name

M62239 T2

M62239 T3

M62239 T4

M62239 T18

M62239 T19

M62239 T20

Table 1186 - Segments of interest

Segment Name

M62239 node 1

M62239 node 4

M62239 node 21

M62239 node 27

M62239. node 0

M62239 node 2

M62239 node 5

M62239 node 7

M62239 node 9

M62239 node 10

M62239 node 11

M62239 node 12

M62239 node 13

M62239 node 16

M62239 node 17

M62239 node 18

M62239 node 19

M62239 node 20

M62239 node 24 M62239 node 28

M62239 node 29

M62239 node 33

M62239 node 34

Table 1187 - Proteins of interest

These sequences are variants of the known protein 4OS ribosomal protein SlO (SwissProt accession identifier RS10_HUMAN), referred to herein as the previously known protein.

The sequence for protein 4OS ribosomal protein SlO is given at the end of the application, as "4OS ribosomal protein SlO amino acid sequence". Protein 4OS ribosomal protein SlO localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein biosynthesis, which are annotation(s) related to Biological

Process; RNA binding; structural protein of ribosome, which are annotation(s) related to Molecular Function; and cytosolic small ribosomal (40S) subunit, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

As noted above, cluster M62239 features 23 segment(s), which were listed in Table 1186 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M62239_node_l according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T18. Table 1188 below describes the starting and ending position of this segment on each transcript.

Table 1188 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62239_P14.

Segment cluster M62239_node_4 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2 and M62239_T3. Table 1189 below describes the starting and ending position of this segment on each transcript.

Table 1189 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62239_P2 and M62239JP1.

Segment cluster M62239_node_21 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T18 and M62239_T19. Table 1190 below describes the starting and ending position of this segment on each transcript. Table 1190 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P14 and M62239_P15.

Segment cluster M62239_node_27 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T20. Table 1191 below describes the starting and ending position of this segment on each transcript.

Table 1191 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M62239_node_0 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T18 and M62239_T19. Table 1192 below describes the starting and ending position of this segment on each transcript.

Table 1192 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62239_P14. This segment can also be found in the following protein(s): M62239_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M62239_node_2 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T18. Table 1193 below describes the starting and ending position of this segment on each transcript. Table 1193 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62239_P14.

Segment cluster M62239_node_5 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T3. Table 1194 below describes the starting and ending position of this segment on each transcript.

Table 1194 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P1.

Segment cluster M62239_node_7 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T4. Table 1195 below describes the starting and ending position of this segment on each transcript. Table 1195 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P3.

Segment cluster M62239_node_9 according to the present invention is supported by 354 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1196 below describes the starting and ending position of this segment on each transcript.

Table 1196 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239_P1, M62239_P3, M62239_P14 and M62239_P15.

Segment cluster M62239_node_10 according to the present invention can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1197 below describes the starting and ending position of this segment on each transcript.

Table 1197 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239JP1, M62239_P3, M62239_P14 and M62239_P15.

Segment cluster M62239_node_l 1 according to the present invention is supported by 364 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1198 below describes the starting and ending position of this segment on each transcript. Table 1198 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239JP1, M62239_P3, M62239_P14 and M62239_P15.

Segment cluster M62239_node_12 according to the present invention can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1199 below describes the starting and ending position of this segment on each transcript.

Table 1199 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239JP1, M62239_P3, M62239JP14 and M62239_P15.

Segment cluster M62239_node_13 according to the present invention can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1200 below describes the starting and ending position of this segment on each transcript.

Table 1200 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239_P1, M62239_P3, M62239_P14 and M62239JH5.

Segment cluster M62239_node_l 6 according to the present invention is supported by 410 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1201 below describes the starting and ending position of this segment on each transcript.

Table 1201 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239_P1, M62239_P3, M62239_P14 and M62239J^>15.

Segment cluster M62239_node_l 7 according to the present invention can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1202 below describes the starting and ending position of this segment on each transcript.

Table 1202 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239_P1,

M62239_P3, M62239_P14 and M62239_P15.

Segment cluster M62239_node_18 according to the present invention is supported by 426 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and

M62239_T19. Table 1203 below describes the starting and ending position of this segment on each transcript.

Table 1203 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239JP1, M62239_P3, M62239__P14 and M62239_P15.

Segment cluster M62239_node_19 according to the present invention is supported by 476 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1204 bebw describes the starting and ending position of this segment on each transcript.

Table 1204 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239JP1, M62239_P3, M62239_P14 and M62239JP15.

Segment cluster M62239_node_20 according to the present invention is supported by 498 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4, M62239_T18 and M62239_T19. Table 1205 below describes the starting and ending position of this segment on each transcript.

Table 1205 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239_P1, M62239_P3, M62239_P14 and M62239_P15.

Segment cluster M62239_node_24 according to the present invention is supported by 543 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3 and M62239_T4. Table 1206 below describes the starting and ending position of this segment on each transcript.

Table 1206 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239_P1 and

M62239 P3.

Segment cluster M62239_node_28 according to the present invention is supported by 502 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4 and M62239_T20. Table 1207 below describes the starting and ending position of this segment on each transcript.

Table 1207 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239_P1 and M62239 P3. Segment cluster M62239_node_29 according to the present invention can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4 and M62239_T20. Table 1208 below describes the starting and ending position of this segment on each transcript.

Table 1208 - Segment location on transcripts

This segment can be found in the following protein(s): M62239JP2, M62239_P1 and M62239 P3.

Segment cluster M62239_node_33 according to the present invention is supported by 427 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4 and M62239_T20. Table 1209 below describes the starting and ending position of this segment on each transcript.

Table 1209 - Segment location on transcripts

This segment can be found in the following protein(s): M62239JP2, M62239_P1 and M62239 P3.

Segment cluster M62239_node_34 according to the present invention is supported by 387 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62239_T2, M62239_T3, M62239_T4 and M62239_T20. Table 1210 below describes the starting and ending position of this segment on each transcript. Table 1210 - Segment location on transcripts

This segment can be found in the following protein(s): M62239_P2, M62239_P1 and M62239JP3.

DESCRIPTION FOR CLUSTER M78378

Cluster M78378 features 8 transcript(s) and 49 segment(s) of interest, the names for which are given in Tables 1211 and 1212, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1213.

Table 1211 - Transcripts of interest

Transcript Name

M78378 T5

M78378 TlO

M78378 TIl

M78378 T13

M78378 T16

M78378 T19

M78378 T20

M78378 T21

Table 1212 - Segments of interest

Segment Name

M78378 node 0

M78378 node 1

M78378 node 2

M78378 node 4

M78378 node 6

M78378 node 7 Table 1213 - Proteins of interest

These sequences are variants of the known protein Tubulin beta-4 chain (SwissProt accession identifier TBB4_HUMAN; known also according to the synonyms Tubulin beta-Ill), referred to herein as the previously known protein.

Protein Tubulin beta-4 chain is known or believed to have the following function(s): Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain. The sequence for protein Tubulin beta-4 chain is given at the end of the application, as "Tubulin beta-4 chain amino acid sequence". Known polymorphisms for this sequence are as shown in Table 1214.

Table 1214 -Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: microtubule-based movement, which are annotation(s) related to Biological Process; structural protein of cytoskeleton; GTP binding, which are annotation(s) related to Molecular Function; and cytoskeleton; microtubule, which are annotation(s) related to

Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>. Cluster M78378 can be used as a diagnostic marker according to overexp ression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 31 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 31 and Table 1215. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues, kidney malignant tumors, hepatocellular carcinoma, lung malignant tumors, prostate cancer and skin malignancies.

31 Table 1215 - Normal tissue distribution

Table 1216 - P values and ratios for expression in cancerous tissue

As noted above, cluster M78378 features 49 segment(s), which were listed in Table 1212 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster M78378_node_0 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378JN1. Table 1217 below describes the starting and ending position of this segment on each transcript.

Table 1217 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23.

Segment cluster M78378_node_l according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T11. Table 1218 below describes the starting and ending position of this segment on each transcript.

Table 1218 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23.

Segment cluster M78378_node_2 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T11. Table 1219 below describes the starting and ending position of this segment on each transcript.

Table 1219 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23.

Segment cluster M78378_node_4 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378JN0 and M78378_T11. Table 1220 below describes the starting and ending position of this segment on each transcript.

Table 1220 - Segment location on transcripts

This segment can be found in the following protein(s): M78378_P23.

Segment cluster M78378_node_6 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T11. Table 1221 below describes the starting and ending position of this segment on each transcript.

Table 1221 - Segment location on transcripts

This segment can be found in the following protein(s): M78378_JP23. Segment cluster M78378_node_7 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T1 L Table 1222 below describes the starting and ending position of this segment on each transcript.

Table 1222 - Segment location on transcripts

This segment can be found in the following protein(s): M78378_P23.

Segment cluster M78378_node_10 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T11. Table 1223 below describes the starting and ending position of this segment on each transcript.

Table 1223 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23.

Segment cluster M78378_node_15 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T13. Table 1224 below describes the starting and ending position of this segment on each transcript.

Table 1224 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P6.

Segment cluster M78378_node_17 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1225 below describes the starting and ending position of this segment on each transcript.

Table 1225 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78378_P6, M78378_P4 and M78378_P11.

Segment cluster M78378_node_22 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T16. Table 1226 below describes the starting and ending position of this segment on each transcript.

Table 1226 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P6. Segment cluster M78378_node_26 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T19. Table 1227 below describes the starting and ending position of this segment on each transcript.

Table 1227 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P4.

Segment cluster M78378_node_27 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T19 and M78378_T20. Table 1228 below describes the starting and ending position of this segment on each transcript.

Table 1228 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P4.

Segment cluster M78378_node_31 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T19 and M78378_T20. Table 1229 below describes the starting and ending position of this segment on each transcript.

Table 1229 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378JP23 and M78378_P4.

Segment cluster M78378_node_34 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T19, M78378_T20 and M78378_T21. Table 1230 below describes the starting and ending position of this segment on each transcript.

Table 1230 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23, M78378_P4 and M78378_P11.

Segment cluster M78378_node_35 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T19 and M78378_T20. Table 1231 below describes the starting and ending position of this segment on each transcript.

Table 1231 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_52 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1232 below describes the starting and ending position of this segment on each transcript. Table 1232 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_56 according to the present invention is supported by 179 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1233 below describes the starting and ending position of this segment on each transcript.

Table 1233 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_58 according to the present invention is supported by 177 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1234 below describes the starting and ending position of this segment on each transcript.

Table 1234 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378JP11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_59 according to the present invention is supported by 148 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1235 below describes the starting and ending position of this segment on each transcript.

Table 1235 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23, M78378_P6, M78378_P4 and M78378_P11. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M78378_node_3 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T11. Table 1236 below describes the starting and ending position of this segment on each transcript.

Table 1236 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78378_P23.

Segment cluster M78378_node_5 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T11. Table 1237 below describes the starting and ending position of this segment on each transcript.

Table 1237 - Segment location on transcripts

This segment can be found in the following protein(s): M78378_P23.

Segment cluster M78378_node_8 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s)" M78378_T5, M78378_T10 and M78378_T1 1. Table 1238 below describes the starting and ending position of this segment on each transcript.

Table 1238 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23.

Segment cluster M78378_node_9 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10 and M78378_T11. Table 1239 below describes the starting and ending position of this segment on each transcript.

Table 1239 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23.

Segment cluster M78378_node_20 according to the present invention is supported by 144 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1240 below describes the starting and ending position of this segment on each transcript.

Table 1240 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23, M78378_P6, M78378_P4 and M78378_P11.

Segment cluster M78378_node_24 according to the present invention is supported by 148 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1241 below describes the starting and ending position of this segment on each transcript.

Table 1241 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23, M78378_P4 and M78378JP11. This segment can also be found in the following protein(s): M78378_P6, since it is in the coding region for the corresponding transcript. Segment cluster M78378_node_25 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1242 below describes the starting and ending position of this segment on each transcript.

Table 1242 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23, M78378_P4 and M78378_P11. This segment can also be found in the following protein(s): M78378_P6, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_28 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T19 and

M78378_T20. Table 1243 below describes the starting and ending position of this segment on each transcript.

Table 1243 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378 JP4.

Segment cluster M78378_node_29 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T19 and M78378_T20. Table 1244 below describes the starting and ending position of this segment on each transcript.

Table 1244 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378JP23 and M78378_P4.

Segment cluster M78378_node_30 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T19 and

M78378_T20. Table 1245 below describes the starting and ending position of this segment on each transcript.

Table 1245 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P4. Segment cluster M78378_node_32 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T19 and M78378_T20. Table 1246 below describes the starting and ending position of this segment on each transcript.

Table 1246 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P4.

Segment cluster M78378_node_33 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T19 and M78378_T20. Table 1247 below describes the starting and ending position of this segment on each transcript.

Table 1247 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P4. Segment cluster M78378_node_36 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1248 below describes the starting and ending position of this segment on each transcript.

Table 1248 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378JP11. This segment can also be found in the following protein(s): M78378_P6 and M78378_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_37 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1249 below describes the starting and ending position of this segment on each transcript.

Table 1249 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P11. This segment can also be found in the following protein(s): M78378_P6 and M78378_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_38 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1250 below describes the starting and ending position of this segment on each transcript.

Table 1250 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P11. This segment can also be found in the following protein(s): M78378_P6 and M78378_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_39 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1251 below describes the starting and ending position of this segment on each transcript.

Table 1251 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P11. This segment can also be found in the following protein(s): M78378_P6 and M78378_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_40 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1252 below describes the starting and ending position of this segment on each transcript.

Table 1252 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378_P11. This segment can also be found in the following protein(s): M78378JP6 and M78378_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_41 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1253 below describes the starting and ending position of this segment on each transcript.

Table 1253 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23 and M78378JP11. This segment can also be found in the following protein(s): M78378_P6 and M78378_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node__42 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1254 below describes the starting and ending position of this segment on each transcript. Table 1254 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378JP23. This segment can also be found in the following protein(s): M78378JP6, M78378_P4 and M78378JP11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_43 according to the present invention is supported by 150 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1255 below describes the starting and ending position of this segment on each transcript.

Table 1255 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_44 according to the present invention is supported by 156 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1256 below describes the starting and ending position of this segment on each transcript.

Table 1256 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378JP23. This segment can also be found in the following protein(s): M78378_P6, M78378JP4 and M78378_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_45 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1257 below describes the starting and ending position of this segment on each transcript. Table 1257 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_46 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1258 below describes the starting and ending position of this segment on each transcript.

Table 1258 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378 J^»6, M78378_P4 and M78378JP11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_49 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1259 below describes the starting and ending position of this segment on each transcript.

Table 1259 - Segment location on transcripts

This segment can be fiund in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378JP11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_50 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1260 below describes the starting and ending position of this segment on each transcript.

Table 1260 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcripts) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378JP11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_51 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1261 below describes the starting and ending position of this segment on each transcript.

Table 1261 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378_P11, since it is in the coding region for the corresponding transcript. Segment cluster M78378_node_53 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1262 below describes the starting and ending position of this segment on each transcript.

Table 1262 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s):

M78378_P6, M78378_P4 and M78378JP11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_54 according to the present invention is supported by 128 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1263 below describes the starting and ending position of this segment on each transcript. Table 1263 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378JP4 and M78378JP11, since it is in the coding region for the corresponding transcript.

Segment cluster M78378_node_55 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1264 below describes the starting and ending position of this segment on each transcript.

Table 1264 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378_P4 and M78378_P11, since it is in the coding region for the corresponding transcript. Segment cluster M78378_node_57 according to the present invention can be found in the following transcript(s): M78378_T5, M78378_T10, M78378_T11, M78378_T13, M78378_T16, M78378_T19, M78378_T20 and M78378_T21. Table 1265 below describes the starting and ending position of this segment on each transcript.

Table 1265 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78378_P23. This segment can also be found in the following protein(s): M78378_P6, M78378JP4 and M78378JU 1, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER M85976

Cluster M85976 features 16 transcript(s) and 37 segment(s) of interest, the names for which are given in Tables 1266 and 1267, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1268.

Table 1266 - Transcripts of interest

Transcript Name

M85976 Tl

M85976 T2

M85976 T3

M85976 T4

M85976 T5

M85976 T6 M85976 T7

M85976 TlO

M85976 TIl

M85976 T15

M85976 T17

M85976 T18

M85976 T26

M85976 T33

M85976 T34

M85976 T36

Table1267-Segmentsofinterest

SegmentName <

M85976 node 0

M85976 node 3

M85976 node 6

M85976 node 26

M85976 node 29

M85976 node 30

M85976 node 34

M85976 node 37

M85976 node 40

M85976 node 41

M85976 node 42

M85976 node 55

M85976 node 57

M85976 node 58

M85976 node 60

M85976 node 61

M85976 node 1

M85976 node 4

M85976 node 5

M85976 node 10

M85976 node 11

M85976 node 12

M85976 node 13

M85976 node 16

M85976 node 17

M85976 node 19

M85976 node 21

M85976 node 33

M85976 node 35

M85976 node 36 M85976 node 39

M85976 node 45

M85976 node 46

M85976 node 47

M85976 node 50

M85976 node 51

M85976 node 59

Table 1268 - Proteins of interest

These sequences are variants of the known protein Thimet oligopeptidase (SwissProt accession identifier MEPD_HUMAN; known also according to the synonyms EC 3.4.24.15; Endopeptidase 24.15; MP78), referred to herein as the previously known protein.

Protein Thimet oligopeptidase is known or believed to have the following function(s): Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. The sequence for protein Thimet oligopeptidase is given at the end of the application, as "Thimet oligopeptidase amino acid sequence". Protein Thimet oligopeptidase localization is believed to be Cytoplasmic. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: metalloendopeptidase, which are annotation(s) related to Molecular Function.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www .ncbi.nlm.nih.gov/projects/LocusLink7>.

Cluster M85976 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 32 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expressbn of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 32 and Table 1269. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, colorectal cancer, epithelial malignant tumors and a mixture of malignant tumors from different tissues. 32 Table 1269 - Normal tissue distribution

Table 1270 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 1271.

Table 1271 - Oligonucleotides related to this cluster

As noted above, cluster M85976 features 37 segment(s), which were listed in Table 1267 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M85976_node_0 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18 and M85976_T36. Table 1272 below describes the starting and ending position of this segment on each transcript.

Table 1272 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P16 and M85976_P26.

Segment cluster M85976_node_3 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18 and M85976_T36. Table 1273 below describes the starting and ending position of this segment on each transcript.

Table 1273 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16 and M85976_P26.

Segment cluster M85976_node_6 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T36. Table 1274 below describes the starting and ending position of this segment on each transcript.

Table 1274 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P26.

Segment cluster M85976_node_26 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18. Table 1275 below describes the starting and ending position of this segment on each transcript.

Table 1275 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16.

Segment cluster M85976_node_29 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17 and M85976_T26. Table 1276 below describes the starting and ending position of this segment on each transcript.

Table 1276 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976JP3 and M85976_P6. This segment can also be found in the following protein(s): M85976_P2, M85976_P4, M85976_P5, M85976_P7, M85976_P10, M85976_P11 and M85976_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_30 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17, M85976_T18 and M85976_T26. Table 1277 below describes the starting and ending position of this segment on each transcript.

Table 1277 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P3 and M85976_P6. This segment can also be found in the following protein(s): M85976_P2, M85976_P4, M85976_P5, M85976_P7, M85976_P10, M85976JP11, M85976_P15 and M85976_P16, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_34 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17, M85976JN8 and M85976_T26. Table 1278 below describes the starting and ending position of this segment on each transcript. Table 1278 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1279.

Table 1279 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P3. This segment can also be found in the following protein(s): M85976_P2, M85976_P4, M85976_P5, M85976_P6, M85976_P7, M85976_P10, M85976JP11, M85976_P15 and M85976JP16, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_37 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T3, M85976_T7 and M85976_T18. Table 1280 below describes the starting and ending position of this segment on each transcript.

Table 1280 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P3. This segment can also be found in the following protein(s): M85976_P7 and M85976_P16, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_40 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976JN, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976JU 1, M85976_T15, M85976_T17, M85976_T18 and M85976_T26. Table 1281 below describes the starting and ending position of this segment on each transcript.

Table 1281 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976JP2, M85976_P3, M85976_P4, M85976_P5, M85976_P6, M85976_P10, M85976_P11 and M85976_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_41 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T4, M85976_T7, M85976_T15 and M85976_T26. Table 1282 below describes the starting and ending position of this segment on each transcript.

Table 1282 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M85976_P7. This segment can also be found in the following protein(s): M85976_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node__42 according to the present invention is supported by 75 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976JN1, M85976_T15, M85976_T17, M85976_T18 and M85976_T26. Table 1283 below describes the starting and ending position of this segment on each transcript.

Table 1283 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P4, M85976_P5, M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976_P2, M85976_P3, M85976_P6, M85976_P10, M85976_P11 and M85976_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_55 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T10 and M85976_T15. Table 1284 below describes the starting and ending position of this segment on each transcript.

Table 1284 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P4. This segment can also be found in the following protein(s): M85976_P10, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_57 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T33 and M85976_T34. Table 1285 below describes the starting and ending position of this segment on each transcript.

Table 1285 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M85976_P25.

Segment cluster M85976_node_58 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T18, M85976_T33 and M85976_T34. Table 1286 below describes the starting and ending position of this segment on each transcript.

Table 1286 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P4, M85976_P5, M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976_P2, M85976_P3, M85976_P6, M85976_P10, M85976JP11 and M85976_P25, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_60 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T1 1, M85976_T15, M85976_T18, M85976_T33 and M85976_T34. Table 1287 below describes the starting and ending position of this segment on each transcript.

Table 1287 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M85976_P2, M85976_P3, M85976_P4, M85976JP5, M85976_P6, M85976_P7, M85976JP10, M85976_P11, M85976_P16 and M85976_P25.

Segment cluster M85976_node_61 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976JT2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17, M85976_T18, M85976_T26, M85976_T33 and M85976_T34. Table 1288 below describes the starting and ending position of this segment on each transcript.

Table 1288 - Segment location on transcripts

This segment can be found in both coding and non-coding legions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P2, M85976_P3, M85976_P4, M85976_P5, M85976_P6, M85976_P7, M85976_P10, M85976JP11, M85976_P16 and M85976_P25. This segment can also be found in the following protein(s): M85976_P15, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M85976_node_l according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18 and M85976_T36. Table 1289 below describes the starting and ending position of this segment on each transcript.

Table 1289 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16 and M85976_P26.

Segment cluster M85976_node_4 according to the present invention can be found in the following transcript(s): M85976_T18 and M85976_T36. Table 1290 below describes the starting and ending position of this segment on each transcript. Table 1290 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16 and M85976_P26.

Segment cluster M85976_node_5 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18 and M85976_T36. Table 1291 below describes the starting and ending position of this segment on each transcript.

Table 1291 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16 and M85976_P26. Segment cluster M85976_node_10 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18. Table 1292 below describes the starting and ending position of this segment on each transcript.

Table 1292 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16.

Segment cluster M85976_node_l 1 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18. Table 1293 below describes the starting and ending position of this segment on each transcript.

Table 1293 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16.

Segment cluster M85976_node_12 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18. Table 1294 below describes the starting and ending position of this segment on each transcript.

Table 1294 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16. Segment cluster M85976_node_13 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18. Table 1295 below describes the starting and ending position of this segment on each transcript.

Table 1295 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16.

Segment cluster M85976_node_16 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T18. Table 1296 below describes the starting and ending position of this segment on each transcript.

Table 1296 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16.

Segment cluster M85976_node_17 according to the present invention can be found in the following transcript(s): M85976_T18. Table 1297 below describes the starting and ending position of this segment on each transcript. Table 1297 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16. Segment cluster M85976_node_19 according to the present invention can be found in the following transcript(s): M85976_T18. Table 1298 below describes the starting and ending position of this segment on each transcript.

Table 1298 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16.

Segment cluster M85976_node_21 according to the present invention is supported by 72 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M85976_T18. Table 1299 below describes the starting and ending position of this segment on each transcript.

Table 1299 - Segment location on transcripts

This segment can be found in the following protein(s): M85976_P16.

Segment cluster M85976_node_33 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17, M85976_T18 and M85976_T26. Table 1300 below describes the starting and ending position of this segment on each transcript.

Table 1300 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P3 and M85976_P6. This segment can also be found in the following protein(s): M85976_P2, M85976_P4, M85976_P5, M85976_P7, M85976_P10, M85976_P11, M85976JP15 and M85976_P16, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_35 according to the present invention can be found in the following transcript(s) : M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17, M85976_T18 and M85976_T26. Table 1301 below describes the starting and ending position of this segment on each transcript.

Table 1301 - Segment location on transcripts

M85976 T26 1381 1387

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P3. This segment can also be found in the following protein(s): M85976_P2, M85976_P4, M85976_P5, M85976_P7, M85976_P10, M85976JP11, M85976_P15 and M85976_P16, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_36 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17, M85976_T18 and M85976_T26. Table 1302 below describes the starting and ending position of this segment on each transcript.

Table 1302 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976JP3. This segment can also be found in the following protein(s): M85976_P2, M85976_P4, M85976_P7, M85976_P10, M85976JP11, M85976_P15 and M85976_P16, since it is in the coding region for the corresponding transcript. Segment cluster M85976_node_39 according to the present invention can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17, M85976_T18 and M85976_T26. Table 1303 below describes the starting and ending position of this segment on each transcript.

Table 1303 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P3, M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976_P2, M85976_P4, M85976_P5, M85976_P6, M85976JP10, M85976_P11 and M85976_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_45 according to the present invention can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17, M85976_T18 and M85976_T26. Table 1304 below describes the starting and ending position of this segment on each transcript. Table 1304 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P4, M85976_P5, M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976_P2, M85976_P3, M85976_P6, M85976_P10, M85976_P11 and M85976_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_46 according to the present invention can be found in the following transcript(s): M85976JN, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T17 and M85976_T18. Table 1305 below describes the starting and ending position of this segment on each transcript.

Table 1305 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P4, M85976JP5, M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976_P2, M85976_P3, M85976_P6, M85976_P10, M85976_P11 and M85976JP15, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_47 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15 and M85976_T18. Table 1306 below describes the starting and ending position of this segment on each transcript. Table 1306 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P4, M85976_P5, M85976_P7 and M85976JP16. This segment can also be found in the following protein(s): M85976_P2, M85976_P3, M85976_P6, M85976_P10 and M85976JP11, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_50 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T15 and M85976_T18. Table 1307 below describes the starting and ending position of this segment on each transcript.

Table 1307 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976JP4, M85976_P5, M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976_P2, M85976JP3, M85976JP6 and M85976_P10, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_51 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976_T1, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15 and M85976_T18. Table 1308 below describes the starting and ending position of this segment on each transcript.

Table 1308 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P4, M85976_P5, M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976JP2, M85976_P3, M85976_P6, M85976JP10 and M85976_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M85976_node_59 according to the present invention is supported by 97 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85976JN, M85976_T2, M85976_T3, M85976_T4, M85976_T5, M85976_T6, M85976_T7, M85976_T10, M85976_T11, M85976_T15, M85976_T18, M85976_T33 and M85976_T34. Table 1309 below describes the starting and ending position of this segment on each transcript.

Table 1309 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85976_P4, M85976_P5, M85976_P7 and M85976_P16. This segment can also be found in the following protein(s): M85976_P2, M85976JP3, M85976JP6, M85976_P10, M85976JP11 and M85976_P25, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER N50847

Cluster N50847 features 1 transcript(s) and 20 segment(s) of interest, the names for which are given in Tables 1310 and 1311, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1312.

Table 1310 - Transcripts of interest

Transcript Name

N50847 T5

Table 1311 - Segments of interest

SegmentName

N50847 node 6

N50847 node 11

N50847 node 12

N50847 node 13 N50847 node 15

N50847 node 24

N50847 node 25

N50847 node 26

N50847 node 7

N50847 node 8

N50847 node 14

N50847 node 16

N50847 node 17

N50847 node 18

N50847 node 19

N50847 node 20

N50847 node 21

N50847 node 22

N50847 node 23

N50847 node 27

Table 1312 - Proteins of interest

Cluster N50847 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 33 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 33 and Table 1313. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and pancreas carcinoma.

Table 1313 - Normal tissue distribution

Table 1314 - P values and ratios for expression in cancerous tissue

As noted above, cluster N50847 features 20 segment(s), which were listed in Table 1311 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster N50847_node_6 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1315 below describes the starting and ending position of this segment on each transcript.

Table 1315 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_ll according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1316 below describes the starting and ending position of this segment on each transcript. Table 1316 - Segment location on transcripts

This segment can be found in the following protein(s): N50847_P3.

Segment cluster N50847_node_12 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1317 below describes the starting and ending position of this segment on each transcript.

Table 1317 - Segment location on transcripts

This segment can be found in the following protein(s): N50847_P3.

Segment cluster N50847_node_l 3 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1318 below describes the starting and ending position of this segment on each transcript.

Table 1318 - Segment location on transcripts

This segment can be found in the following protein(s): N50847_P3.

Segment cluster N50847_node_l 5 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1319 below describes the starting and ending position of this segment on each transcript.

Table 1319 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N50847JP3. Segment cluster N50847_node_24 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1320 below describes the starting and ending position of this segment on each transcript.

Table 1320 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_25 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1321 below describes the starting and ending position of this segment on each transcript.

Table 1321 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_26 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1322 below describes the starting and ending position of this segment on each transcript.

Table 1322 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster N50847_node_7 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1323 below describes the starting and ending position of this segment on each transcript.

Table 1323 - Segment location on transcripts

This segment can be found in the following protein(s): N50847_P3.

Segment cluster N50847_node_8 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1324 below describes the starting and ending position of this segment on each transcript.

Table 1324 - Segment location on transcripts

This segment can be found in the following protein(s): N50847JP3. Segment cluster N50847__node_14 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1325 below describes the starting and ending position of this segment on each transcript.

Table 1325 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_16 according to the present invention can be found in the following transcript(s): N50847_T5. Table 1326 below describes the starting and ending position of this segment on each transcript.

Table 1326 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_17 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1327 below describes the starting and ending position of this segment on each transcript.

Table 1327 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_l 8 according to the present invention can be found in the following transcript(s): N50847_T5. Table 1328 below describes the starting and ending position of this segment on each transcript.

Table 1328 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_l 9 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1329 below describes the starting and ending position of this segment on each transcript.

Table 1329 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_20 according to the present invention can be found in the following transcript(s): N50847_T5. Table 1330 below describes the starting and ending position of this segment on each transcript.

Table 1330 - Segment location on transcripts

N50847 T5 | 1769 | 1788 |

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_21 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1331 below describes the starting and ending position of this segment on each transcript.

Table 1331 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_22 according to the present invention can be found in the following transcript(s): N50847_T5. Table 1332 below describes the starting and ending position of this segment on each transcript.

Table 1332 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_23 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1333 below describes the starting and ending position of this segment on each transcript. Table 1333 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N50847_P3.

Segment cluster N50847_node_27 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N50847_T5. Table 1334 below describes the starting and ending position of this segment on each transcript.

Table 1334 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N50847_P3.

DESCRIPTION FOR CLUSTER N69694

Cluster N69694 features 5 transcript(s) and 11 segment(s) of interest, the names for which are given in Tables 1335 and 1336, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1337.

Table 1335 - Transcripts of interest

Transcript Name

N69694 Tl

N69694 T2

N69694 T8

N69694 TlO N69694 TI l

Table 1336 - Segments of interest

SegmentName

N69694 node 4

N69694 node 21

N69694 node 0

N69694 node 5

N69694 node 7

N69694 node 9

N69694 node 10

N69694 node 11

N69694 node 15

N69694 node 16

N69694 node 18

Table 1337 - Proteins of interest

Cluster N69694 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 34 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 34 and Table 1338. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues. Table 1338 - Normal tissue distribution

Table 1339 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 1340.

Table 1340 - Oligonucleotides related to this cluster

As noted above, cluster N69694 features 11 segment(s), which were listed in Table 1336 above and fcr which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster N69694_node_4 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T1 , N69694_T8 and N69694_T10. Table 1341 below describes the starting and ending position of this segment on each transcript.

Table 1341 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N69694_P2, N69694_P8 and N69694_P9.

Segment cluster N69694_node_21 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T1, N69694_T2, N69694_T8, N69694_T10 and N69694_T11. Table 1342 below describes the starting and ending psition of this segment on each transcript.

Table 1342 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N69694_P8. This segment can also be found in the following protein(s): N69694_P2, N69694J^>3, N69694_P9 and N69694_P10, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster N69694_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T2. Table 1343 below describes the starting and ending position of this segment on each transcript.

Table 1343 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P3.

Segment cluster N69694_node_5 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T1, N69694_T2, N69694_T8 and N69694_T10. Table 1344 below describes the starting and ending position of this segment on each transcript.

Table 1344 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P2, N69694_P3, N69694 P8 and N69694 P9.

Segment cluster N69694_node_7 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T1, N69694_T2, N69694_T8 and N69694_T10. Table 1345 below describes the starting and ending position of this segment on each transcript.

Table 1345 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P2, N69694_P3, N69694JP8 and N69694JP9.

Segment cluster N69694_node_9 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T8. Table 1346 below describes the starting and ending position of this segment on each transcript.

Table 1346 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P8.

Segment cluster N69694_node_10 according to the present invention can be found in the following transcript(s): N69694_T8. Table 1347 below describes the starting and ending position of this segment on each transcript.

Table 1347 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P8.

Segment cluster N69694_node_l 1 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T1, N69694_T2, N69694_T8 and N69694_T10. Table 1348 below describes the starting and ending position of this segment on each transcript. Table 1348 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P2, N69694_P3, N69694_P8 and N69694_P9.

Segment cluster N69694_node_15 according to the present invention can be found in the following transcript(s): N69694_T1, N69694_T2 and N69694_T8. Table 1349 below describes the starting and ending position of this segment on each transcript.

Table 1349 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P2, N69694_P3 and N69694 P8.

Segment cluster N69694_node_16 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T1, N69694_T2 and N69694_T8. Table 1350 below describes the starting and ending position of this segment on each transcript.

Table 1350 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P2, N69694_P3 and N69694_P8.

Segment cluster N69694_node_l 8 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N69694_T11. Table 1351 below describes the starting and ending position of this segment on each transcript.

Table 1351 - Segment location on transcripts

This segment can be found in the following protein(s): N69694_P10.

DESCRIPTION FOR CLUSTER R01445

Cluster R01445 features 14 transcript(s) and 28 segment(s) of interest, the names for which are given in Tables 1352 and 1353, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1354.

Table 1352 - Transcripts of interest

Transcript Name

R01445 Tl

R01445 T2

R01445 T3

R01445 T4

R01445 T5

R01445 T6

R01445 T7

R01445 T8

R01445 TlO

R01445 TIl

R01445 T12

R01445 T14

R01445 T15

R01445 T17 Table 1353 - Segments of interest

Segment Name

RO 1445 node 0

RO 1445 node 2

R01445 node 8

R01445 node 16

RO 1445 node 19

R01445 node 21

R01445 node 24

R01445 node 25

R01445 node 26

R01445 node 29

R01445 node 33

R01445 node 35

R01445 node 36

R01445 node 38

R01445 node 39

R01445 node 4

R01445 node 5

R01445 node 7

R01445 node 10

R01445 node 12

R01445 node 13

R01445 node 14

R01445 node 18

R01445 node 23

R01445 node 28

RO 1445 node 31

R01445 node 32

R01445 node 37

Table 1354 - Proteins of interest

R01445 P8 R01445 Tl

Cluster RO 1445 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 35 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 35 and Table 1355. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: lung malignant tumors.

35

Table 1355 - Normal tissue distribution

Table 1356 - P values and ratios for expression in cancerous tissue

As noted above, cluster RO 1445 features 28 segment(s), which were listed in Table 1353 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R01445_node_0 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4,

R01445_T6, R01445_T7, R01445_T8, R01445_T10, RO1445_T11 and R01445_T14. Table

1357 below describes the starting and ending position of this segment on each transcript.

Table 1357 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P3 and R01445_P4. This segment can also be found in the following protein(s): R01445_P8, R01445_P2 and R01445_P7, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T5. Table 1358 below describes the starting and ending position of this segment on each transcript.

Table 1358 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P4.

Segment cluster R01445_node_8 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): RO1445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10, RO1445_T11 and R01445_T14. Table 1359 below describes the starting and ending position of this segment on each transcript.

Table 1359 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P3 and R01445_P4. This segment can also be found in the following protein(s): R01445_P8, R01445_P2 and R01445_P7, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_16 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T3. Table 1360 below describes the starting and ending position of this segment on each transcript.

Table 1360 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P3.

Segment cluster R01445_node_19 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10, R01445_T11 and R01445_T12. Table 1361 below describes the starting and ending position of this segment on each transcript.

Table 1361 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445 P3 and R01445_P5. This sgment can also be found in the following protein(s): R01445_P8, R01445_P2 and R01445_P4, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_21 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4,

R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10 and R01445_T11. Table 1362 below describes the starting and ending position of this segment on each transcript.

Table 1362 - Segment location on transcripts

I R01445 T11 J I 677 I 852 I

This segment can be found in the following protein(s): R01445_P8, R01445_P2, R01445_P3 and R01445_P4.

Segment cluster R01445_node_24 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T2, R01445_T8, R01445 T10 and RO1445_T11. Table 1363 below describes the starting and ending position of this segment on each transcript.

Table 1363 - Segment location on transcripts

This segment can be found in the following protein(s): R01445_P2.

Segment cluster R01445_node_25 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10, RO1445_T11 and R01445_T12. Table 1364 below describes the starting and ending position of this segment on each transcript.

Table 1364 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript (s) that are related to the following protein(s): R01445_P2. This segment can also be found in the following protein(s): R01445_P8, R01445_P3, R01445_P4 and R01445JP5, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node__26 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T10. Table 1365 below describes the starting and ending position of this segment on each transcript.

Table 1365 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P2.

Segment cluster R01445_node_29 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): RO1445_T11. Table 1366 below describes the starting and ending position of this segment on each transcript.

Table 1366 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P2.

Segment cluster R01445_node_33 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T8. Table 1367 below describes the starting and ending position of this segment on each transcript.

Table 1367 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P2.

Segment cluster R01445_node_35 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T15 and R01445_T17. Table 1368 below describes the starting and ending position of this segment on each transcript.

Table 1368 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R01445_node_36 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T12, R01445_T15 and R01445_T17. Table 1369 below describes the starting and ending position of this segment on each transcript. Table 1369 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P2. This segment can also be found in the following protein(s): R01445_P8, R01445_P3, R01445_P4 and R01445_P5, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_38 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): RO1445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T12, R01445_T14, R01445_T15 and R01445_T17. Table 1370 below describes the starting and ending position of this segment on each transcript. Table 1370 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P8, R01445_P2, R01445_P3, R01445JP4 and R01445_P5. This segment can also be found in the following protein(s): R01445_P7, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_39 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): RO1445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T12, R01445_T14 and R01445_T15. Table 1371 below describes the starting and ending position of this segment on each transcript.

Table 1371 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P8, R01445_P2, R01445_P3, R01445_P4, R01445_P5 and R01445 P7. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R01445_node_4 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T6. Table 1372 below describes the starting and ending position of this segment on each transcript.

Table 1372 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445JP4.

Segment cluster R01445_node_5 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T6 and R01445_T7. Table 1373 below describes the starting and ending position of this segment on each transcript.

Table 1373 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P4.

Segment cluster R01445_node_7 according to the present invention can be found in the following transcript(s): R01445_T4. Table 1374 below describes the starting and ending position of this segment on each transcript. Table 1374 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445JP4.

Segment cluster R01445_node_10 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcripts): RO1445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10, RO1445_T11 and R01445_T14. Table 1375 below describes the starting and ending position of this segment on each transcript.

Table 1375 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445JP3. This segment can also be found in the following protein(s): R01445_P8, R01445_P2, R01445_P4 and R01445JP7, since it is in the coding region for the corresponding transcript. Segment cluster R01445_node_12 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10, RO1445_T11 and R01445_T14. Table 1376 below describes the starting and ending position of this segment on each transcript.

Table 1376 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P3. This segment can also be found in the following protein(s):

R01445_P8, R01445_P2, R01445_P4 and R01445_P7, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_13 according to the present invention can be found in the following transcript(s): RO1445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10 and RO1445_T11. Table 1377 below describes the starting and ending position of this segment on each transcript.

Table 1377 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R01445_P3. This segment can also be found in the following protein(s): R01445_P8, R01445_P2 and R01445_P4, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_14 according to the present invention can be found in the following transcript(s): RO1445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10 and RO1445_T11. Table 1378 below describes the starting and ending position of this segment on each transcript.

Table 1378 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P3. This segment can also be found in the following protein(s): R01445_P8, R01445_P2 and R01445_P4, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_18 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T12. Table 1379 below describes the starting and ending position of this segment on each transcript.

Table 1379 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P5.

Segment cluster R01445_node_23 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, R01445_T10, R01445_T11 and R01445_T12. Table 1380 below describes the starting and ending position of this segment on each transcript. Table 1380 - Segment location on transcripts

This segment can be found in the following protein(s): R01445JP8, R01445JP2, R01445_P3, R01445_P4 and R01445_P5.

Segment cluster R01445_node_28 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript®: RO1445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8, RO1445_T11 and R01445_T12. Table 1381 below describes the starting and ending position of this segment on each transcript. Table 1381 ~ Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P2. This segment can also be found in the following protein(s): R01445_P8, R01445_P3, R01445_P4 and R01445JP5, since i is in the coding region for the corresponding transcript.

Segment cluster R01445_node_31 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T8 and R01445_T12. Table 1382 below describes the starting and ending position of this segment on each transcript.

Table 1382 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445JP2. This segment can also be found in the following protein(s): R01445_P8, R01445 P3, R01445JP4 and R01445JP5, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_32 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): RO1445_T1, R01445_T2, R01445_T3, R01445_T4,

R01445_T5, R01445_T6, R01445_T7, R01445_T8 and R01445_T12. Table 1383 below describes the starting and ending position of this segment on each transcript.

Table 1383 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P2. This segment can also be found in the following protein(s): R01445_P8, R01445_P3, R01445JP4 and R01445_P5, since it is in the coding region for the corresponding transcript.

Segment cluster R01445_node_37 according to the present invention can be found in the following transcript(s): R01445_T1, R01445_T2, R01445_T3, R01445_T4, R01445_T5, R01445_T6, R01445_T7, R01445_T12, R01445_T14, R01445_T15 and R01445JU7. Table 1384 below describes the starting and ending position of this segment on each transcript.

Table 1384 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R01445_P8, R01445_P2, R01445_P3, R01445_P4 and R01445_P5. This segment can also be found in the following protein(s): R01445_P7, since it is in the coding region for the corresponding transcript. DESCRIPTION FOR CLUSTER Rl 0078

Cluster Rl 0078 features 8 transcript(s) and 33 segment(s) of interest, the names for which are given in Tables 1385 and 1386, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1387.

Table 1385 - Transcripts of interest

TranscriptName

Rl0078 T7

Rl0078 T8

Rl0078 T16

Rl0078 T28

Rl0078 T31

Rl0078 T32

Rl0078 T34

Rl0078 T35

Table 1386-Segmentsofinterest

R10078 node 35

R10078 node 36

R10078 node 37

Rl 0078 node 38

R10078 node 39

Rl 0078 node 40

R10078 node 42

R10078 node 49

R10078 node 50

R10078 node 51

Rl 0078 node 52

Rl 0078 node 53

Table 1387 - Proteins of interest

Cluster Rl 0078 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 36 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 36 and Table 1388. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors,, epithelial malignant tumors, a mixture of malignant tumors from different tissues and skin malignancies.

Table 1388 - Normal tissue distribution

Table 1389 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 1390.

Table 1390 - Oligonucleotides related to this cluster cteotiiewame»ii?«i%afi '#v«erexpresse,a*in«ι Bfϊ

R10175 0 0 29339 lung malignant tumors LUN

As noted above, cluster Rl 0078 features 33 segment(s), which were listed in Table 1386 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R10078_node_l according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T8, R10078_T34 and R10078_T35. Table 1391 below describes the starting and ending position of this segment on each transcript.

Table 1391 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_Pl.

Segment cluster R10078_node_3 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T34. Table 1392 below describes the starting and ending position of this segment on each transcript.

Table 1392 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R10078_node_5 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T34 and R10078_T35. Table 1393 below describes the starting and ending position of this segment on each transcript.

Table 1393 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R10078_node_7 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7 and R10078_T16. Table 1394 below describes the starting and ending position of this segment on each transcript.

Table 1394 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R10078JP5. Segment cluster R10078_node_26 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found h the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1395 below describes the starting and ending position of this segment on each transcript.

Table 1395 - Segment location on transcripts

This segment can be found in the following protein(s): R10078JP5 and R10078_Pl.

Segment cluster R10078_node_27 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1396 below describes the starting and ending position of this segment on each transcript.

Table 1396 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R10078_Pl.

Segment cluster R10078_node_34 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1397 below describes the starting and ending position of this segment on each transcript.

Table 1397 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R10078_Pl.

Segment cluster R10078_node_43 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7 and R10078_T16. Table 1398 below describes the starting and ending position of this segment on each transcript.

Table 1398 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1399.

Table 1399 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): R10078_P5.

Segment cluster R10078_node_44 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1400 below describes the starting and ending position of this segment on each transcript. Table 1400 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1401.

Table 1401 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_P5. This segment can also be found in the following protein(s): R10078JP1, since it is in the coding region for the corresponding transcript.

Segment cluster R10078_node_46 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1402 below describes the starting and ending position of this segment on each transcript.

Table 1402 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_P5. This segment can also be found in the following protein(s): R10078_Pl, since it is in the coding region for the corresponding transcript

Segment cluster R10078_node_48 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T28, R10078_T31 and R10078J32. Table 1403 below describes the starting and ending position of this segment on each transcript. Table 1403 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R10078_node_54 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8, R10078_T16, R10078_T28, R10078_T31 and R10078_T32. Table 1404 below describes the starting and ending position of this segment on each transcript.

Table 1404 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_P5 and R10078JP1.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R10078_node_8 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7 and R10078_T16. Table 1405 below describes the starting and ending position of this segment on each transcript.

Table 1405 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R10078_P5.

Segment cluster R10078_node_14 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1406 below describes the starting and ending position of this segment on each transcript.

Table 1406 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078__P5 and R10078JPL

Segment cluster R10078_node_15 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1407 below describes the starting and ending position of this segment on each transcript.

Table 1407 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R10078_P5 and R10078_Pl.

Segment cluster R10078_node_16 according to the present invention can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1408 below describes the starting and ending position of this segment on each transcript.

Table 1408 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078JP5 and R10078_Pl.

Segment cluster R10078_node_17 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1409 below describes the starting and ending position of this segment on each transcript.

Table 1409 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_P5 and Rl 0078 JPl.

Segment cluster R10078_node_18 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1410 below describes the starting and ending position of this segment on each transcript.

Table 1410 - Segment location on transcripts

This segment can be found in the following protein(s): R10078JP5 and R10078_Pl.

Segment cluster R10078_node_19 according to the present invention can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1411 below describes the starting and ending position of this segment on each transcript.

Table 1411 - Segment location on transcripts

This segment can be found in the following protein(s): R10078JP5 and R10078_Pl .

Segment cluster R10078_node_32 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1412 below describes the starting and ending position of this segment on each transcript.

Table 1412 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R10078JP1.

Segment cluster R10078_node_33 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1413 below describes the starting and ending position of this segment on each transcript.

Table 1413 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R10078_Pl.

Segment cluster R10078_node_35 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1414 below describes the starting and ending position of this segment on each transcript. Table 1414 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R1OO78_P1.

Segment cluster R10078_node_36 according to the present invention can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1415 below describes the starting and ending position of this segment on each transcript.

Table 1415 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R10078_Pl.

Segment cluster R10078_node_37 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1416 below describes the starting and ending position of this segment on each transcript.

Table 1416 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R1OO78_P1. Segment cluster R10078_node_38 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1417 below describes the starting and ending position of this segment on each transcript.

Table 1417 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R10078JP1.

Segment cluster R10078_node_39 according to the present invention can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1418 below describes the starting and ending position of this segment on each transcript.

Table 1418 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R10078_Pl.

Segment cluster R10078_node_40 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078JΪ7, R10078_T8 and R10078_T16. Table 1419 below describes the starting and ending position of this segment on each transcript.

Table 1419 - Segment location on transcripts

This segment can be found in the following protein(s): R10078_P5 and R10078 P1.

Segment cluster R10078_node_42 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8 and R10078_T16. Table 1420 below describes the starting and ending position of this segment on each transcript.

Table 1420 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1421.

Table 1421 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): R10078_P5 and R10078_Pl.

Segment cluster R10078_node_49 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T28, R10078_T31 and R10078_T32. Table 1422 below describes the starting and ending position of this segment on each transcript.

Table 1422 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R10078_node_50 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8, R10078_T16, R10078_T28, R10078_T31 and R10078 T32. Table 1423 below describes the starting and ending position of this segment on each transcript.

Table 1423 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_P5. This segment can also be found in the following protein(s): R1OO78_P1, since it is in the coding region for the corresponding transcript.

Segment cluster R10078_node_51 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R10078_T16, R10078_T31 and R10078_T32. Table 1424 below describes the starting and ending position of this segment on each transcript.

Table 1424 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_P5.

Segment cluster R10078_node__52 according to the present invention is supported by 60 libraries. The number of libraries was determined as previous Iy described. This segment can be found in the following transcript(s): R10078_T7, R10078_T8, R10078_T16, R10078_T28, R10078_T31 and R10078_T32. Table 1425 below describes the starting and ending position of this segment on each transcript.

Table 1425 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_P5. This segment can also be found in the following protein(s): R1OO78_P1, since it is in the coding region for the corresponding transcript.

Segment cluster R10078_node_53 according to the present invention can be found in the following transcript(s): R10078_T7, R10078_T8, R10078_T16, R10078_T28, R10078_T31 and R10078_T32. Table 1426 below describes the starting and ending position of this segment on each transcript.

Table 1426 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R10078_P5. This segment can also be found in the following protein(s): R10078_Pl, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER R20779

Cluster R20779 features 1 transcript(s) and 9 segment(s) of interest, the names for which are given in Tables 1427 and 1428, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1429.

Table 1427 - Transcripts of interest

Transcript Name

R20779 T15

Table 1428 - Segments of interest

Segment Name

R20779 node 0

R20779 node 2

R20779 node 7

R20779 node 9

R20779 node 12

R20779 node 1

R20779 node 3

R20779 node 10

R20779 node 11 Table 1429 - Proteins of interest

These sequences are variants of the known protein Stanniocalcin 2 precursor (SwissProt accession identifier STC2_HUMAN; known also according to the synonyms STC-2; Stanniocalcin- related protein; STCRP; STC -related protein), referred to herein as the previously known protein.

Protein Stanniocalcin 2 precursor is known or believed to have the following function(s):

Has an antthypocalcemic action on calcium and phosphate homeostasis. The sequence for protein Stanniocalcin 2 precursor is given at the end of the application, as "Stanniocalcin 2 precursor amino acid sequence". Protein Stanniocalcin 2 precursor localization is believed to be

Secreted (Potential).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell surface receptor linked signal transduction; cell-cell signaling; nutritional response pathway, which are annotation(s) related to Biological Process; hormone, which are annotation(s) related to Molecular Function; and extracellular, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster R20779 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 37 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 37 and Table 1430. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and lung malignant tumors.

Table 1430 - Normal tissue distribution

Table 1431 - P values and ratios for expression in cancerous tissue

As noted above, cluster R20779 features 9 segment(s), which were listed in Table 1428 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R20779_node_0 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20779_T15. Table 1432 below describes the starting and ending position of this segment on each transcript. Table 1432 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20779_P10.

Segment cluster R20779_node_2 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20779_T15. Table 1433 below describes the starting and ending position of this segment on each transcript.

Table 1433 - Segment location on transcripts

R20779 T15 1337 1506

This segment can be found in the following protem(s): R20779_P10.

Segment cluster R20779_node_7 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20779JT15. Table 1434 below describes the starting and ending position of this segment on each transcript.

Table 1434 - Segment location on transcripts

This segment can be found in the following protein(s): R20779_P10.

Segment cluster R20779_node_9 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20779_T15. Table 1435 below describes the starting and ending position of this segment on each transcript.

Table 1435 - Segment location on transcripts

This segment can be found in the following protein(s): R20779_P10.

Segment cluster R20779__node_12 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20779_T15. Table 1436 below describes the starting and ending position of this segment on each transcript.

Table 1436 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1437.

Table 1437 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): R20779_P10.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R20779_node_l according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20779_T15. Table 1438 below describes the starting and ending position of this segment on each transcript.

Table 1438 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20779_P10.

Segment cluster R20779_node_3 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20779_T15. Table 1439 below describes the starting and ending position of this segment on each transcript.

Table 1439 - Segment location on transcripts

This segment can be found in the following protein(s): R20779 P10.

Segment cluster R20779_node_10 according to the present invention can be found in the following transcript(s): R20779_T15. Table 1440 below describes the starting and ending position of this segment on each transcript. Table 1440 - Segment location on transcripts

This segment can be found in the following protein(s): R20779_P10.

Segment cluster R20779_node_l 1 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20779_T15. Table 1441 below describes the starting and ending position of this segment on each transcript.

Table 1441 - Segment location on transcripts

This segment can be found in the following protein(s): R20779_P10.

DESCRIPTION FOR CLUSTER R36629 Cluster R36629 features 5 transcript(s) and 14 segment(s) of interest, the names for which are given in Tables 1442 and 1443, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1444.

Table 1442 - Transcripts of interest

Transcript Name

R36629 T4

R36629 T5

R36629_ _T10

R36629 T13

R36629 T15

Table 1443 - Segments of interest

Segment Nam©

R36629 node 0

R36629 node 3

R36629 node 5

R36629 node 12

R36629 node 15

R36629 node 24

R36629 node 7

R36629 node 8

R36629 node 18

R36629 node 19

R36629 node 20

R36629 node 21

R36629 node 22

R36629 node 23

Table 1444 - Proteins of interest

These sequences are variants of the known protein Hypothetical protein KIAAOlOl

(SwissProt accession identifier Y101_HUMAN), referred to herein as the previously known protein.

The sequence for protein Hypothetical protein KIAAOlOl is given at the end of the application, as "Hypothetical protein KIAAOlOl amino acid sequence". Cluster R36629 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 38 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 38 and Table 1445. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: transitional cell carcinoma, brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, malignant tumors involving the bone marrow and uterine malignancies.

Table 4 - Normal tissue distribution

Table 1445 - P values and ratios for expression in cancerous tissue

As noted above, cluster R36629 features 14 segment(s), which were listed in Table 1443 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R36629_node_0 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4 and R36629_T15. Table 1447 below describes the starting and ending position of this segment on each transcript.

Table 1446 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1448.

Table 1447 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): R36629_P2.

Segment cluster R36629_node 3 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T15. Table 1449 below describes the starting and ending position of this segment on each transcript.

Table 1448 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R36629_P2.

Segment cluster R36629_node_5 according to the present invention is supported by 151 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T10 and R36629_T13. Table 1450 below describes the starting and ending position of this segment on each transcript.

Table 1449 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R36629_node_12 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T13. Table 1451 below describes the starting and ending position of this segment on each transcript.

Table 1450 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R36629_node_15 according to the present invention is supported by 173 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4 and R36629_T5. Table 1452 below describes the starting and ending position of this segment on each transcript.

Table 1451 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R36629_P2.

Segment cluster R36629_node_24 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4, R36629_T5 and R36629_T10. Table 1453 below describes the starting and ending position of this segment on each transcript.

Table 1452 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R36629_P2.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R36629_node_7 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629 T5. Table 1454 below describes the starting and ending position of this segment on each transcript.

Table 1453 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R36629_node_8 according to the present invention is supported by 173 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4, R36629_T5, R36629_T10 and R36629_T13. Table 1455 below describes the starting and ending position of this segment on each transcript. Table 1454 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R36629_P2.

Segment cluster R36629_node_18 according to the present invention is supported by 160 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4, R36629_T5 and R36629_T10. Table 1456 below describes the starting and ending position of this segment on each transcript.

Table 1455 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R36629_P2.

Segment cluster R36629_node_ 19 according to the present invention can be found in the following transcript(s): R36629_T4, R36629_T5 and R36629_T10. Table 1457 below describes the starting and ending position of this segment on each transcript.

Table 1456 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R36629_P2.

Segment cluster R36629_node_20 according to the present invention is supported by 162 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4, R36629 T5 and R36629_T10. Table 1458 below describes the starting and ending position of this segment on each transcript.

Table 1457 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R36629_P2.

Segment cluster R36629_node_21 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4, R36629_T5 and R36629_T10. Table 1459 below describes the starting and ending position of this segment on each transcript.

Table 1458 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R36629_P2. Segment cluster R36629_node_22 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4, R36629_T5 and R36629_T10. Table 1460 below describes the starting and ending position of this segment on each transcript.

Table 1459 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R36629_P2.

Segment cluster R36629_node_23 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R36629_T4, R36629_T5 and R36629_T10. Table 1461 below describes the starting and ending position of this segment on each transcript.

Table 1460 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R36629_P2.

DESCRIPTION FOR CLUSTER R47363 Cluster R47363 features 10 transcπpt(s) and 45 segment(s) of interest, the names for which are given in Tables 1461 and 1462, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1463.

Table 1461 - Transcripts of interest

Transcript Name

R47363 T3

R47363 T22

R47363 T23

R47363 T25

R47363 T28

R47363 T29

R47363 T30

R47363 T35

R47363 T38

R47363 T40

Table 1462 - Segments of interest

Segment Name

R47363 node 5

R47363 node 11

R47363 node 12

R47363 node 26

R47363 node 33

R47363 node 35

R47363 node 40

R47363 node 43

R47363 node 45

R47363 node 46

R47363 node 47

R47363 node 53

R47363_ _node_ _.55

R47363 node 57

R47363 node 64

R47363 node 67

R47363 node 68

R47363 node 77

R47363 node 78

R47363 node 0

R47363 node 2

R47363 node 14

Table 1463 - Proteins of interest

Cluster R47363 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 39 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 39 and Table 1464. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: pancreas carcinoma and prostate cancer.

Table 1464 - Normal tissue distribution

Table 1465 - P values and ratios for expression in cancerous tissue

As noted above, cluster R47363 features 45 segment(s), which were listed in Table 1462 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R47363_node_5 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T22 and R47363_T38. Table 1466 below describes the starting and ending position of this segment on each transcript.

Table 1466 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8. This segment can also be found in the following protein(s): R47363_P25, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_l 1 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30 and R47363_T35. Table 1467 below describes the starting and ending position of this segment on each transcript. Table 1467 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363JP18. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19, R47363_P17 and R47363_P22, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_12 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R.47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1468 below describes the starting and ending position of this segment on each transcript.

Table 1468 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8 and R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19, R47363_P17, R47363_P22 and R47363_P25, since it is in the coding region for the corresponding transcript. Segment cluster R47363_node_26 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T38. Table 1469 below describes the starting and ending position of this segment on each transcript.

Table 1469 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P25.

Segment cluster R47363_node_33 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T35 and R47363_T38. Table 1470 below describes the starting and ending position of this segment on each transcript.

Table 1470 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P25. This segment can also be found in the following protein(s): R47363_P22, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_35 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T22 and R47363_T28. Table 1471 below describes the starting and ending position of this segment on each transcript.

Table 1471 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8 and R47363_P18.

Segment cluster R47363_node_40 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1472 below describes the starting and ending position of this segment on each transcript.

Table 1472 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P15, R47363_P19 and R47363_P17, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_43 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1473 below describes the starting and ending position of this segment on each transcript.

Table 1473 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363JP18. This segment can also be found in the following protein(s): R47363J^>4, R47363_P8, R47363_P13, R47363_P15, R47363_P19 and R47363_P17, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_45 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1474 below describes the starting and ending position of this segment on each transcript.

Table 1474 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363JP15, R47363_P19 and R47363_P17, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_46 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T28. Table 1475 below describes the starting and ending position of this segment on each transcript.

Table 1475 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R47363_P18.

Segment cluster R47363_node_47 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25,

R47363_T28, R47363_T29 and R47363_T30. Table 1476 below describes the starting and ending position of this segment on each transcript.

Table 1476 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P15, R47363_P18, R47363_P19 and R47363_P17.

Segment cluster R47363_node_53 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1477 below describes the starting and ending position of this segment on each transcript.

Table 1477 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P15, R47363_P18, R47363_P19 and R47363_P17.

Segment cluster R47363_node_55 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1478 below describes the starting and ending position of this segment on each transcript. Table 1478 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_JP4, R47363_P8, R47363_P13, R47363_P15, R47363_P18, R47363_P19 and R47363_P17.

Segment cluster R47363_node_57 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1479 below describes the starting and ending position of this segment on each transcript.

Table 1479 - Segment location on transcripts

This segment can be found in the following protein(s): R47363 P4, R47363_P8, R47363_P13, R47363_P15, R47363_P18, R47363_P19 and R47363_P17.

Segment cluster R47363_node_64 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1480 below describes he starting and ending position of this segment on each transcript. Table 1480 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P19. This segment can also be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P15, R47363_P18 and R47363_P17, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_67 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30 and R47363_T40. Table 1481 below describes the starting and ending position of this segment on each transcript.

Table 1481 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P19. This segment can also be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P15, R47363_P18, R47363_P17 and R47363_P27, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_68 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T25. Table 1482 below describes the starting and ending position of this segment on each transcript.

Table 1482 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P15.

Segment cluster R47363_node_77 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T23, R47363_T30 and R47363_T40. Table 1483 below describes the starting and ending position of this segment on each transcript.

Table 1483 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P17. This segment can also be found in the following ρrotein(s): R47363_P13 and R47363_P27, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_78 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30 and R47363_T40. Table 1484 below describes the starting and ending position of this segment on each transcript.

Table 1484 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P15, R47363_P19 and R47363_P17. This segment can also be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P18 and R47363 JP27, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R47363_node_0 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T22 and R47363_T38. Table 1485 below describes the starting and ending position of this segment on each transcript.

Table 1485 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8. This segment can also be found in the following protein(s): R47363_P25, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_2 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T22 and R47363_T38. Table 1486 below describes the starting and ending position of this segment on each transcript.

Table 1486 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8. This segment can also be found in the following protein(s): R47363_P25, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_14 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1487 below describes the starting and ending position of this segment on each transcript.

Table 1487 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8 and R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19, R47363_P17,

R47363_P22 and R47363JP25, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_15 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1488 below describes the starting and ending position of this segment on each transcript.

Table 1488 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363JP8 and R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19, R47363_P17, R47363_P22 and R47363_P25, since it is in the coding region for the corresponding transcript. Segment cluster R47363_node_16 according to the present invention can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1489 below describes the starting and ending position of this segment on each transcript.

Table 1489 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcriρt(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363 P8 and R47363JP18. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19, R47363_P17,

R47363_P22 and R47363_P25, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_18 according to the present invention can be found in the following transcript(s): R47363_T3, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1490 below describes the starting and ending position of this segment on each transcript.

Table 1490 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19, R47363_P17, R47363_P22 and

R47363_P25, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_20 according to the present invention can be found in the following transcript(s): R47363_T22. Table 1491 below describes the starting and ending position of this segment on each transcript.

Table 1491 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8.

Segment cluster R47363_node_21 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1492 below describes the starting and ending position of this segment on each transcript.

Table 1492 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R47363_P8 and R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19, R47363_P17,

R47363_P22 and R47363_P25, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_22 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1493 below describes the starting and ending position of this segment on each transcript.

Table 1493 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8 and R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363JP15, R47363_P19, R47363_P17, R47363_P22 and R47363_P25, since it is in the coding region for the corresponding transcript. Segment cluster R47363_node_24 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363JB0, R47363_T35 and R47363_T38. Table 1494 below describes the starting and ending position of this segment on each transcript.

Table 1494 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8 and R47363_P18. This segment can also be found in the following protein(s): R47363_P4, R47363JP13, R47363_P15, R47363_P19, R47363_P17,

R47363_P22 and R47363_P25, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_27 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25,

R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1495 below describes the starting and ending position of this segment on each transcript.

Table 1495 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8, R47363_P18 and R47363_P25. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19,

R47363_P17 and R47363_P22, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_28 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363 T25, R47363_T28, M7363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1496 below describes the starting and ending position of this segment on each transcript.

Table 1496 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363JP8, R47363_P18 and R47363_P25. This segment can also be found in the following protein(s): R47363_P4, R47363JP13, R47363_P15, R47363_P19, R47363_P17 and R47363_P22, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_29 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1497 below describes the starting and ending position of this segment on each transcript.

Table 1497 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8, R47363JP18 and R47363JP25. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19, R47363_P17 and R47363_P22, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_32 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30, R47363_T35 and R47363_T38. Table 1498 below describes the starting and ending position of this segment on each transcript.

Table 1498 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P8, R47363JP18 and R47363_P25. This segment can also be found in the following protein(s): R47363_P4, R47363_P13, R47363_P15, R47363_P19,

R47363_P17 and R47363_P22, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_37 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T23, R47363_T25, R47363_T29 and R47363_T30. Table 39 below describes the starting and ending position of this segment on each transcript.

Table 1499 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P4, R47363_P13,

R47363_P15, R47363_P19 and R47363_P17. Segment cluster R47363_node_41 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1500 below describes the starting and ending position of this segment on each transcript.

Table 1500 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P18. This segment can also be found in the following protein(s):

R47363_P4, R47363_P8, R47363_P13, R47363_P15, R47363_P19 and R47363_P17, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_49 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25,

R47363_T28, R47363_T29 and R47363_T30. Table 1501 below describes the starting and ending position of this segment on each transcript.

Table 1501 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P15, R47363_P18, R47363_P19 and R47363_P17.

Segment cluster R47363_node_51 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1502 below describes the starting and ending position of this segment on each transcript. Table 1502 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P4, R47363_P8, R47363JP13, R47363_P15, R47363_P18, R47363_P19 and R47363_P17.

Segment cluster R47363_node_59 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363 T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1503 below describes the starting and ending position of this segment on each transcript. Table 1503 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363JP15, R47363_P18, R47363_P19 and R47363_P17.

Segment cluster R47363_node_60 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363J22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T30. Table 1504 below describes the starting and ending position of this segment on each transcript.

Table 1504 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P15, R47363_P18, R47363_P19 and R47363_P17.

Segment cluster R47363_node_62 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T29. Table 1505 below describes the starting and ending position of this segment on each transcript.

Table 1505 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P19.

Segment cluster R47363_node_66 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T40. Table 1506 below describes the starting and ending position of this segment on each transcript.

Table 1506 - Segment location on transcripts

This segment can be found in the following protein(s): R47363_P27.

Segment cluster R47363_node_69 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29 and R47363_T40. Table 1507 below describes the starting and ending position of this segment on each transcript.

Table 1507 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P15 and R47363_P19. This segment can also be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P18 and R47363_P27, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_72 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30 and R47363_T40. Table 1508 below describes the starting and ending position of this segment on each transcript. Table 1508 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P15 and R47363_P19. This segment can also be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P18, R47363_P17 and

R47363_P27, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_74 according to the present invention can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30 and R47363_T40. Table 1509 below describes the starting and ending position of this segment on each transcript.

Table 1509 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P15, R47363_P19 and R47363_P17. This segment can also be found in the following protein(s): R47363_P4, R47363_P8, R47363_P13, R47363_P18 and

R47363_P27, since it is in the coding region for the corresponding transcript.

Segment cluster R47363_node_76 according to the present invention can be found in the following transcript(s): R47363_T3, R47363_T22, R47363_T23, R47363_T25, R47363_T28, R47363_T29, R47363_T30 and R47363_T40. Table 1510 below describes the starting and ending position of this segment on each transcript.

Table 1510 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R47363_P15, R47363_P19 and R47363_P17. This segment can also be found in the following protein(s): R47363_P4, R47363JP8, R47363_P13, R47363_P18 and R47363_P27, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER R49883

Cluster R49883 features 1 transcript(s) and 5 segment(s) of interest, the names for which are given in Tables 1511 and 1512, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1513.

Table 1511 - Transcripts of interest

Transcript Name

R49883 T54

Table 1512 - Segments of interest

Segment Name

R49883 node 8

R49883 node 1

R49883 node 2

R49883 node 5

R49883 node 6

Table 1513 - Proteins of interest

These sequences are variants of the known protein Tumor necrosis factor receptor superfamily member 5 precursor (SwissProt accession identifier TNR5_HUMAN; known also according to the synonyms CD40L receptor; B-cell surface antigen CD40; CDw40; Bp50), referred to herein as the previously known protein.

Protein Tumor necrosis factor receptor superfamily member 5 precursor is known or believed to have the following function(s): Receptor for TNFSF5/CD40L. The sequence for protein Tumor necrosis factor receptor superfamily member 5 precursor is given at the end of the application, as "Tumor necrosis factor receptor superfamily member 5 precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 1514.

Table 1514 - Amino acid mutations for Known Protein

Protein Tumor necrosis factor receptor superfamily member 5 precursor localization is believed to be Type I membrane protein (isoform I); secreted (isoform II).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein complex assembly; apoptosis; inflammatory response; immune response; signal transduction; developmental processes; antimicrobial humoral response (sensu Vertebrata); platelet activation, which are annotation(s) related to Biological Process; receptor; transmembrane receptor, which are annotation(s) related to Molecular Function; and integral plasma membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster R49883 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 40 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 40 and Table 1515. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors.

Table 1515 - Normal tissue distribution

Table 1516- P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 1517.

Table 1517 - Oligonucleotides related to this cluster-

As noted above, cluster R49883 features 5 segment(s), which were listed in Table 1512 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R49883_node_8 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R49883_T54. Table 1518 below describes the starting and ending position of this segment on each transcript.

Table 1518 - Segment location on transcripts

This segment can be found m a non-coding region of transcπpt(s) that are related to the following protein(s): R49883JP31.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R49883_node_l according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R49883_T54. Table 1519 below describes the starting and ending position of this segment on each transcript.

Table 1519 - Segment location on transcripts

This segment can be found in the following protein(s): R49883_P31.

Segment cluster R49883_node_2 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R49883_T54. Table 1520 below describes the starting and ending position of this segment on each transcript.

Table 1520 - Segment location on transcripts

This segment can be found in the following protein(s): R49883_P31. Segment cluster R49883_node_5 according to the present invention is supported by 72 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): R49883_T54. Table 1521 below describes the starting and ending position of this segment on each transcript.

Table 1521 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R49883_P31.

Segment cluster R49883_node_6 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R49883_T54. Table 1522 below describes the starting and ending position of this segment on each transcript.

Table 1522 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R49883_P31.

DESCRIPTION FOR CLUSTER R60180

Cluster R60180 features 8 transcript(s) and 24 segment(s) of interest, the names for which are given in Tables 1523 and 1524, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1525.

Table 1523 - Transcripts of interest

Transcript Name R6O18O T7

R60180 T9

R60180 T13

R60180 T18

R60180 T19

R60180 T22

R60180 T24

R6O18O T28

Table 1524 - Segments of interest

Segment Name

R60180 node 4

R60180 node 20

R60180 node 21

R60180 node 25

R60180 node 29

R60180_ _node_ _38

R6O18O node 41

R60180 node 45

R60180 node 46

R60180 node 2

R60180 node 8

R60180 node 10

R60180 node 11

R60180 node 14

R60180 node 15

R6O18O node 16

R60180 node 18

R60180 node 22

R60180 node 27

R60180 node 30

R60180 node 33

R60180_ node _34

R60180 node 43

R60180 node 44

Table 1525 - Proteins of interest

These sequences are variants of the known protein Activator 1 40 kDa subunit (SwissProt accession identifier RFC2_HUMAN; known also according to the synonyms Replication factor C 40 kDa subunit; Al 40 kDa subunit; RF-C 40 kDa subunit; RFC40), referred to herein as the previously known protein.

Protein Activator 1 40 kDa subunit is known or believed to have the following function(s): THE ELONGATION OF PRIMED DNA TEMPLATES BY DNA POLYMERASE DELTA AND EPSILON REQUIRES THE ACTION OF THE ACCESSORY PROTEINS PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) AND ACTIVATOR 1. THE 40 kDa SUBUNIT BINDS ATP. The sequence for protein Activator 1 40 kDa subunit is given at the end of the application, as "Activator 1 40 kDa subunit amino acid sequence". Known polymorphisms for this sequence are as shown in Table 1526.

Table 1526 - Amino acid mutations for Known Protein

Protein Activator 1 40 kDa subunit localization is believed to be Nuclear (Probable).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: DNA replication, which are annotation(s) related to Biological

Process; nucleotide binding; DNA binding; ATP binding, which are annotation(s) related to

Molecular Function; and nucleus; DNA replication factor C complex, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www. ncbi.nlm.nm.gov/projects/LocusLink/>. Cluster R60180 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 41 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 41 and Table 1527. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, kidney malignant tumors, myosarcoma, pancreas carcinoma, skin malignancies and uterine malignancies.

Table 1527 - Normal tissue distribution

Table 1528 - P values and ratios for expression in cancerous tissue

As noted above, cluster R60180 features 24 segment(s), which were listed in Table 1524 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R60180_node_4 according to the present invention is supported by 105 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13 and R60180_T18. Table 1529 below describes the starting and ending position of this segment on each transcript. Table 1529 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P5 and R60180_P8. This segment can also be found in the following protein(s): R60180_P4, since it is in the coding region for the corresponding transcript.

Segment cluster R60180_node_20 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T19 and R60180_T22. Table 1530 below describes the starting and ending position of this segment on each transcript.

Table 1530 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P9. This segment can also be found in the following protein(s): R60180JP12, since it is in the coding region for the corresponding transcript.

Segment cluster R60180_node_21 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T19. Table 1531 below describes the starting and ending position of this segment on each transcript. Table 1531 - Segment location on transcripts

This segment can be found in the following protein(s): R60180_P9.

Segment cluster R60180_node_25 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180 T19 and R60180_T22. Table 1532 below describes the starting and ending position of this segment on each transcript.

Table 1532 - Segment location on transcripts

This segment can be found in the following protein(s): R60180_P4, R60180_P5, R60180_P8, R60180_P9 and R60180_P12.

Segment cluster R60180__node_29 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T24 and R60180_T28. Table 1533 below describes the starting and ending position of this segment on each transcript.

Table 1533 - Segment location on transcripts

This segment can be found in the following protem(s): R60180_P14 and R60180_P16.

Segment cluster R60180_node_38 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7. Table 1534 below describes the starting and ending position of this segment on each transcript.

Table 1534 - Segment location on transcripts

This segment can be found in the following protein(s): R60180JP4.

Segment cluster R60180_node_41 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180JN9, R60180_T22 and R60180_T24. Table 1535 below describes the starting and ending position of this segment on each transcript.

Table 1535 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P4. This segment can also be found in the following protein(s): R60180_P5, R60180JP8, R60180_P9, R60180_P12 and R60180_P14, since it is in the coding region for the corresponding transcript.

Segment cluster R60180_node_45 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180_T19, R60180_T22 and R60180_T24. Table 1536 below describes the starting and ending position of this segment on each transcript.

Table 1536 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P4, R60180_P5, R60180_P8, R60180_P9, R60180_P12 and R60180 P14.

Segment cluster R60180_node_46 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180_T19, R60180_T22 and R60180_T24. Table 1537 below describes the starting and ending position of this segment on each transcript. Table 1537 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P4, R60180J^>5, R60180_P8, R60180_P9, R60180_P12 and R60180 P14.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R60180_node_2 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180 T9, R60180_T13 and R60180_T18. Table 1538 below describes the starting and ending position of this segment on each transcript. Table 1538 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P4, R60180_P5 and R60180_P8.

Segment cluster R60180_node_8 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13 and R60180JQ8. Table 1539 below describes the starting and ending position of this segment on each transcript. Table 1539 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P5 and R60180 P8. This segment can also be found in the following protein(s): R60180 P4, since it is in the coding region for the corresponding transcript.

Segment cluster R60180__node_10 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T13. Table 1540 below describes the starting and ending position of this segment on each transcript.

Table 1540 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P5.

Segment cluster R60180_node_l l according to the present inventbn is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13 and R60180_T18. Table 1541 below describes the starting and ending position of this segment on each transcript.

Table 1541 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180JP5 and R60180 P8. This segment can also be found in the following protein(s): R60180_P4, since it is in the coding region for the corresponding transcript.

Segment cluster R60180_node_14 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T9, R60180_T13 and R60180_T18. Table 1542 below describes the starting and ending position of this segment on each transcript.

Table 1542 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R60180_P5 and R60180_P8.

Segment cluster R60180_node_15 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13 and R60180_T18. Table 1543 below describes the starting and ending position of this segment on each transcript.

Table 1543 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R60180_P5 and R60180_P8. This segment can also be found in the following protein(s): R60180_P4, since it is in the coding region for the corresponding transcript.

Segment cluster R60180_node_16 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13 and R60180_T18. Table 1544 below describes the starting and ending position of this segment on each transcript.

Table 1544 - Segment location on transcripts

This segment can be found in the following protein(s): R60180_P4, R60180_P5 and R60180 P8.

Segment cluster R60180_node_18 according to the present invention is supported by 97 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9 and R60180_T13. Table 1545 below describes the starting and ending position of this segment on each transcript.

Table 1545 - Segment location on transcripts

This segment can be found in the following protein(s): R60180_P4 and R60180_P5.

Segment cluster R60180_node_22 according to the present invention is supported by 105 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180_T19 and R60180 T22. Table 1546 below describes the starting and ending position of this segment on each transcript.

Table 1546 - Segment location on transcripts

This segment can be found in the following protein(s): R60180_P4, R6O180_P5, R60180_P8, R60180_P9 and R60180_P12.

Segment cluster R60180_node_27 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18,

R60180_T19 and R60180_T22. Table 1547 below describes the starting and ending position of this segment on each transcript.

Table 1547 - Segment location on transcripts

This segment can be found in the following protein(s): R60180 P4, R60180_P5, R60180_P8, R60180_P9 and R60180_P12.

Segment cluster R60180_node_30 according to the present invention is supported by 95 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180_T19, R60180_T22, R60180_T24 and R60180_T28. Table 1548 below describes the starting and ending position of this segment on each transcript. Table 1548 - Segment location on transcripts

This segment can be found in the following protein(s): R60180_P4, R60180_P5, R60180_P8, R60180_P9, R60180_P12, R60180_P14 and R60180_P16.

Segment cluster R60180_node_33 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180_T19, R60180_T22, R60180_T24 and R60180_T28. Table 1549 below describes the starting and ending position of this segment on each transcript. Table 1549 - Segment location on transcripts

This segment can be found in the following protein(s): R60180_P4, R60180_P5, R60180_P8, R60180_P9, R60180_P12, R60180_P14 and R60180_P16.

Segment cluster R60180_node_34 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T28. Table 1550 below describes the starting and ending position of this segment on each transcript.

Table 1550 - Segment location on transcripts

This segment can be found in the following protein(s): R60180_P16.

Segment cluster R60180_node_43 according to the present invention can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180_T19, R60180_T22 and R60180_T24. Table 1551 below describes the starting and ending position of this segment on each transcript.

Table 1551 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R60180_P4, R60180_P5, R60180_P8, R60180JP9, R60180_P12 and R60180JP14.

Segment cluster R60180_node_44 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R60180_T7, R60180_T9, R60180_T13, R60180_T18, R60180_T19, R60180_T22 and R60180_T24. Table 1552 below describes the starting and ending position of this segment on each transcript.

Table 1552 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R60180_P4, R60180_P5, R60180_P8, R60180_P9, R60180_P12 and R60180_P14.

DESCRIPTION FOR CLUSTER T07144

Cluster T07144 features 4 transcript(s) and 32 segment(s) of interest, the names for which are given in Tables 1553 and 1554, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1555.

Table 1553 - Transcripts of interest

Transcript Name

T07144 T14

T07144 T20 T07144 T22

T07144 T27

Table1554-Segmentsofinterest

SegmentNana*

T07144 node 0

T07144 node 2

T07144 node 21

T07144 node 23

T07144 node 26

T07144 node 28

T07144 node 30

T07144 node 31

T07144 node 37

T07144 node 39

T07144 node 43

T07144 node 45

T07144 node 48

T07144 node 52

T07144 node 53

T07144 node 54

T07144 node 62

T07144 node 64

T07144 node 66

T07144 node 15

T07144 node 20

T07144 node 24

T07144 node 34

T07144 node 35

T07144 node 46

T07144 node 50

T07144 node 55

T07144 node 56

T07144 node 57

T07144 node 58

T07144 node 60

T07144 node 61

Table 1555 - Proteins of interest

These sequences are variants of the known protein Beta-catenin (SwissProt accession identifier CTNB-HUMAN; known also according to the synonyms PRO2286), referred to herein as the previously known protein.

Protein Beta-catenin is known or believed to have the following function(s): Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway. The sequence for protein Beta-catenin is given at the end of the application, as "Beta-catenin amino acid sequence". Known polymorphisms for this sequence are as shown in Table 1556.

Table 1556 - Amino acid mutations for Known Protein

Protein Beta-catenin localization is believed to be Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDHl. Translocates to the nucleus when it is stabilized (low level of phosphorylation). The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription; transcription regulation, from Pol II promoter; cell adhesion; Wnt receptor signaling pathway, which are annotation(s) related to Biological Process; signal transducer; structural protein; protein binding, which are annotation(s) related to Molecular Function; and nucleus; cytoskeleton; plasma membrane; intercellular junction, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster T07144 features 32 segment(s), which were listed in Table 1554 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T07144_node_0 according to the present hvention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T22 and T07144_T27. Table 1557 below describes the starting and ending position of this segment on each transcript.

Table 1557 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): TO7144_P1 and T07144_P12. Segment cluster T07144_node_2 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1558 below describes the starting and ending position of this segment on each transcript.

Table 1558 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13.

Segment cluster T07144_node_21 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20, T07144_T22 and T07144_T27. Table 1559 below describes the starting and ending position of this segment on each transcript.

Table 1559 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13. This segment can also be found in the following protein(s): TO7144_P1 and T07144_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T07144_node_23 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T22 and T07144_T27. Table 1560 below describes the starting and ending position of this segment on each transcript.

Table 1560 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13. This segment can also be found in the following protein(s): TO7144_P1 and T07144_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T07144_node_26 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20, T07144_T22 and T07144_T27. Table 1561 below describes the starting and ending position of this segment on each transcript.

Table 1561 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13. This segment can also be found in the following protein(s): TO7144_P1 and T07144_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T07144_node_28 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20, T07144_T22 and T07144_T27. Table 1562 below describes the starting and ending position of this segment on each transcript.

Table 1562 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13, TO7144_P1 and T07144 P12.

Segment cluster T07144_node__30 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20, T07144_T22 and T07144_T27. Table 1563 below describes the starting and ending position of this segment on each transcript.

Table 1563 - Segment location on transcripts

This segment can be found in the following protein(s): T07144JP13, TO7144_P1 and T07144 P12.

Segment cluster T07144_node_31 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T27. Table 1564 below describes the starting and ending position of this segment on each transcript.

Table 1564 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P12.

Segment cluster T07144_node_37 according to the present invention is supported by 136 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1565 below describes the starting and ending position of this segment on each transcript.

Table 1565 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and T07144JP1.

Segment cluster T07144_node_39 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1566 below describes the starting and ending position of this segment on each transcript.

Table 1566 - Segment location on transcripts

This segment can be found in the following protein(s): T07144JP13 and T07144JP1.

Segment cluster T07144_node_43 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1567 below describes the starting and ending position of this segment on each transcript.

Table 1567 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and TO7144_P1.

Segment cluster T07144_node_45 according to the present invention is supported by 148 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1568 below describes the starting and ending position of this segment on each transcript.

Table 1568 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and T07144JP1.

Segment cluster T07144_node_48 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1569 below describes the starting and ending position of this segment on each transcript.

Table 1569 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and T07144JP1.

Segment cluster T07144jnode_52 according to the present invention is supported by 171 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1570 below describes the starting and ending position of this segment on each transcript.

Table 1570 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and T07144JP1.

Segment cluster T07144_node_53 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1571 below describes the starting and ending position of this segment on each transcript.

Table 1571 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07144_P13.

Segment cluster T07144_node_54 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1572 below describes the starting and ending position of this segment on each transcript. Table 1572 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13.

Segment cluster T07144_node_62 according to the present invention is supported by 176 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1573 below describes the starting and ending position of this segment on each transcript.

Table 1573 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13.

Segment cluster T07144_node_64 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T22. Table 1574 below describes the starting and ending position of this segment on each transcript.

Table 1574 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): TO7144_P1. Segment cluster T07144_node_66 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T22. Table 1575 below describes the starting and ending position of this segment on each transcript.

Table 1575 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144JP1.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T07144_node_15 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20, T07144_T22 and T07144_T27. Table 1576 below describes the starting and ending position of this segment on each transcript.

Table 1576 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13. This segment can also be found in the following protein(s): TO7144_P1 and T07144_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T07144jnode_20 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20, T07144_T22 and T07144_T27. Table 1577 below describes the starting and ending position of this segment on each transcript.

Table 1577 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13. This segment can also be found in the following protein(s): TO7144_P1 and T07144_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T07144_node_24 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20, T07144_T22 and T07144_T27. Table 1578 below describes the starting and ending position of this segment on each transcript.

Table 1578 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): TO7144_P13. This segment can also be found in the following protein(s): TO7144_P1 and T07144_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T07144_node_34 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1579 below describes the starting and ending position of this segment on each transcript.

Table 1579 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and TO7144_P1.

Segment cluster T07144_node_35 according to the present invention can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1580 below describes the starting and ending position of this segment on each transcript.

Table 1580 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and T07144JP1.

Segment cluster T07144_node_46 according to the present invention can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1581 below describes the starting and ending position of this segment on each transcript.

Table 1581 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and T07144JP1.

Segment cluster T07144_node_50 according to the present invention is supported by 115 libraπes. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14, T07144_T20 and T07144_T22. Table 1582 below describes the starting and ending position of this segment on each transcript.

Table 1582 - Segment location on transcripts

This segment can be found in the following protein(s): T07144_P13 and TO7144_P1.

Segment cluster T07144_node_55 according to the present invention can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1583 below describes the starting and ending position of this segment on each transcript. Table 1583 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13. Segment cluster T07144_node_56 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1584 below describes the starting and ending position of this segment on each transcript.

Table 1584 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13.

Segment cluster T07144_node_57 according to the present invention is supported by 105 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1585 below describes the starting and ending position of this segment on each transcript.

Table 1585 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13.

Segment cluster T07144_node_58 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1586 below describes the starting and ending position of this segment on each transcript.

Table 1586 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13.

Segment cluster T07144_node_60 according to the present invention can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1587 below describes the starting and ending position of this segment on each transcript.

Table 1587 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13.

Segment cluster T07144_node_61 according to the present invention can be found in the following transcript(s): T07144_T14 and T07144_T20. Table 1588 below describes the starting and ending position of this segment on each transcript.

Table 1588 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07144_P13.

DESCRIPTION FOR CLUSTER T07259 Cluster T07259 features 7 transcript(s) and 33 segment(s) of interest, the names for which are given in Tables 1589 and 1590, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1591.

Table 1589 - Transcripts of interest

Transcript Name

T07259 T3

T07259 T4

T07259_ J₇

T07259 T9

T07259 T25

T07259 T26

T07259 T27

Table 1590 - Segments of interest

SegmentName

T07259 node 0

T07259 node 2

T07259 node 3

T07259 node 6

T07259 node 10

T07259 node 12

T07259 node 14

T07259 node 17

T07259 node 20

T07259 node 29

T07259 node 31

T07259 node 33

T07259 node 40

T07259 node 42

T07259 node 46

T07259 node 50

T07259 node 52

T07259 node 59

T07259 node 62

T07259 node 64

T07259 node 66

T07259 node 68

T07259 node 9

T07259 node 13

T07259 node 19 T07259 node 22

T07259 node 24

T07259 node 26

T07259 node 27

T07259 node 36

T07259 node 38

T07259 node 57

T07259 node 67

Table 1591 - Proteins of interest

These sequences are variants of the known protein Hypothetical protein KIAA0250 (SwissProt accession identifier Y250JHUMAN), referred to herein as the previously known protein.

The sequence for protein Hypothetical protein KIAA0250 is given at the end of the application, as "Hypothetical protein KIAA0250 amino acid sequence".

Cluster T07259 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 42 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following iesults were obtained as shown with regard to the histograms in

Figure 42 and Table 1592. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: prostate cancer. Table 1592 - Normal tissue distribution

Table 1593 - P values and ratios for expression in cancerous tissue

As noted above, cluster T07259 features 33 segment(s), which were listed in Table 1590 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T07259_node_0 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T7, T07259_T25 and T07259_T26. Table 1594 below describes the starting and ending position of this segment on each transcript.

Table 1594 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P4 and T07259_P5. This segment can also be found in the following protein(s): T07259_P16 and T07259_P17, since it is in the coding region for the corresponding transcript. Segment cluster T07259_node_2 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T4. Table 1595 below describes the starting and ending position of this segment on each transcript.

Table 1595 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P4.

Segment cluster T07259_node_3 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4 and T07259_T25. Table 1596 below describes the starting and ending position of this segment on each transcript.

Table 1596 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P4. This segment can also be found in the following protein(s): T07259_P16, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_6 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4 and T07259_T25. Table 1597 below describes the starting and ending position of this segment on each transcript. Table 1597 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07259_P16. This segment can also be found in the following protein(s): T07259_P4, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_10 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T25. Table 1598 below describes the starting and ending position of this segment on each transcript.

Table 1598 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P16.

Segment cluster T07259_node_12 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T27. Table 1599 below describes the starting and ending position of this segment on each transcript.

Table 1599 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T07259_node_14 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T26 and T07259_T27. Table 1600 below describes the starting and ending position of this segment on each transcript.

Table 1600 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P17.

Segment cluster T07259_node_17 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4 and T07259_T7. Table 1601 below describes the starting and ending position of this segment on each transcript.

Table 1601 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P5. This segment can also be found in the following protein(s): T07259_P4, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_20 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1602 below describes the starting and ending position of this segment on each transcript.

Table 1602 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P5. This segment can also be found in the following protein(s): T07259_P4, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_29 according to the present invention is supported by 28 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1603 below describes the starting and ending position of this segment on each transcript.

Table 1603 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P5. This segment can also be found in the following protein(s): T07259_P4, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_31 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1604 below describes the starting and ending position of this segment on each transcript.

Table 1604 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259JP5.

Segment cluster T07259_node_33 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1605 below describes the starting and ending position of this segment on each transcript.

Table 1605 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_40 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1606 below describes the starting and ending position of this segment on each transcript.

Table 1606 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259JP5.

Segment cluster T07259_node_42 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1607 below describes the starting and ending position of this segment on each transcript.

Table 1607 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_46 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1608 below describes the starting and ending position of this segment on each transcript.

Table 1608 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5. Segment cluster T07259_node_50 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1609 below describes the starting and ending position of this segment on each transcript.

Table 1609 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_52 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1610 below describes the starting and ending position of this segment on each transcript.

Table 1610 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_59 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1611 below describes the starting and ending position of this segment on each transcript.

Table 1611 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_62 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1612 below describes the starting and ending position of this segment on each transcript.

Table 1612 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_64 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1613 below describes the starting and ending position of this segment on each transcript.

Table 1613 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5. Segment cluster T07259_node_66 according to the present invention is supported by 272 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1614 below describes the starting and ending position of this segment on each transcript.

Table 1614 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_68 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1615 below describes the starting and ending position of this segment on each transcript.

Table 1615 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P4 and T07259_P5.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster T07259_node_9 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7, T07259_T25 and T07259_T26. Table 1616 below describes the starting and ending position of this segment on each transcript.

Table 1616 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P5 and T07259_P16. This segment can also be found in the following protein(s): T07259_P4 and T07259_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_13 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7, T07259_T26 and T07259_T27. Table 1617 below describes the starting and ending positbn of this segment on each transcript. Table 1617 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P5. This segment can also be found in the following protein(s): T07259_P4 and T07259_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_19 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T9. Table 1618 below describes the starting and ending position of this segment on each transcript.

Table 1618 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07259_P5.

Segment cluster T07259_node_22 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T7 and T07259_T9. Table 1619 below describes the starting and ending position of this segment on each transcript.

Table 1619 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07259_P5.

Segment cluster T07259_node_24 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1620 below describes the starting and ending position of this segment on each transcript.

Table 1620 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P5. This segment can also be found in the following protein(s): T07259_P4, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_26 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4 and T07259_T7. Table 1621 below describes the starting and ending position of this segment on each transcript.

Table 1621 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P5. This segment can also be found in the following protein(s): T07259_P4, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_27 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1622 below describes the starting and ending position of this segment on each transcript.

Table 1622 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P5. This segment can also be found in the following protein(s): T07259_P4, since it is in the coding region for the corresponding transcript.

Segment cluster T07259_node_36 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1623 below describes the starting and ending position of this segment on each transcript.

Table 1623 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_38 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1624 below describes the starting and ending position of this segment on each transcript. Table 1624 - Segment location on transcripts

This segment can be found in the following protein(s): T07259JP4 and T07259_P5.

Segment cluster T07259_node_57 according to the present invention is supported by 39 libraries. The number of Ibraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1625 below describes the starting and ending position of this segment on each transcript.

Table 1625 - Segment location on transcripts

This segment can be found in the following protein(s): T07259_P4 and T07259_P5.

Segment cluster T07259_node_67 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07259_T3, T07259_T4, T07259_T7 and T07259_T9. Table 1626 below describes the starting and ending position of this segment on each transcript.

Table 1626 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07259_P4 and T07259JP5.

DESCRIPTION FOR CLUSTER T07775

Cluster T07775 features 4 transcript(s) and 49 segment(s) of interest, the names for which are given in Tables 1627 and 1628, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1629.

Table 1627 - Transcripts of interest

TranscriptName

T07775 T16

T07775 T17

T07775 T18

T07775 T21

Table1628-Segmentsofinterest

SegmentNanw

T07775 node 4

T07775 node 10

T07775 node 16

T07775 node 18

T07775 node 21

T07775 node 46

T07775 node 48

T07775 node 51

T07775 node 53

T07775 node 55

T07775 node 68

T07775 node 73

T07775 node 74

T07775 node 75

T07775 node 81

T07775 node 84

T07775 node 86

T07775 node 87

T07775 node 88

Table 1629 - Proteins of interest

These sequences are variants of the known protein Interleukin enhancer-binding factor 3 (SwissProt accession identifier ILF3_HUMAN; known also according to the synonyms Nuclear factor of activated T cells-90; NF-AT-90; Double- stranded RNA-binding protein 76; DRBP76; Translational control protein 80; TCP80; Nuclear factor associated with dsRNA; NFAR; M- phase phosphoprotein 4; MPP4), referred to herein as the previously known protein. Protein Interleukin enhancer-binding factor 3 is known or believed to have the following function(s): May facilitate double- stranded RNA-regulated gene expression at the level of post- transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucocidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N- methyltransferase 1 activity. The sequence for protein Interleukin enhancer-binding factor 3 is given at the end of the application, as "Interleukin enhancer-binding factor 3 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 1630.

Table 1630 - Amino acid mutations for Known Protein

Protein Interleukin enhancer-binding factor 3 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: M phase; transcription regulation, which are annotation(s) related to Biological Process; DNA binding; RNA polymerase II transcription factor; double -stranded RNA binding, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>. Cluster T07775 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 43 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 43 and Table 1631. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: adrenal cortical carcinoma, epithelial malignant tumors, a mixture of malignant tumors from different tissues, hepatocellular carcinoma, myosarcoma and uterine malignancies.

Table 1631 - Normal tissue distribution

Table 1632 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 1633.

Table 1633 - Oligonucleotides related to this cluster

As noted above, cluster T07775 features 49 segment(s), which were listed in Table 1628 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T07775_node_4 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16 and T07775_T21. Table 1634 below describes the starting and ending position of this segment on each transcript.

Table 1634 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_10 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16. Table 1635 below describes the starting and ending position of this segment on each transcript.

Table 1635 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29. Segment cluster T07775_node_l 6 according to the present invention is supported by 130 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1636 below describes the starting and ending position of this segment on each transcript.

Table 1636 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_l 8 according to the present invention is supported by 139 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1637 below describes the starting and ending position of this segment on each transcript.

Table 1637 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775JP29, since it is in the coding region for the corresponding transcript. Segment cluster T07775_node_21 according to the present invention is supported by 160 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1638 below describes the starting and ending position of this segment on each transcript.

Table 1638 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_46 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1639 below describes the starting and ending position of this segment on each transcript.

Table 1639 - Segment location on transcripts

This segment can be βund in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775JP26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript. Segment cluster T07775_node_48 according to the present invention is supported by 136 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1640 below describes the starting and ending position of this segment on each transcript.

Table 1640 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_51 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1641 below describes the starting and ending position of this segment on each transcript.

Table 1641 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775JP26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript. Segment cluster T07775_node_53 according to the present invention is supported by 145 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1642 below describes the starting and ending position of this segment on each transcript.

Table 1642 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of tanscript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775JP26. This segment can also be found in the following protein(s): T07775JP29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_55 according to the present invention is supported by 144 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1643 below describes the starting and ending position of this segment on each transcript.

Table 1643 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript. Segment cluster T07775_node_68 according to the present invention is supported by 130 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T 18 and T07775_T21. Table 1644 below describes the starting and ending position of this segment on each transcript.

Table 1644 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775JP26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_73 according to the present invention is supported by 137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1645 below describes the starting and ending position of this segment on each transcript.

Table 1645 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript. Segment cluster T07775_node_74 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T21. Table 1646 below describes the starting and ending position of this segment on each transcript.

Table 1646 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26.

Segment cluster T07775_node_75 according to the present invention is supported by 186 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775JU8 and T07775_T21. Table 1647 below describes the starting and ending position of this segment on each transcript.

Table 1647 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_81 according to the present invention is supported by 215 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1648 below describes the starting and ending position of this segment on each transcript. Table 1648 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_84 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1649 below describes the starting and ending position of this segment on each transcript.

Table 1649 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_86 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1650 below describes the starting and ending position of this segment on each transcript.

Table 1650 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_87 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1651 below describes the starting and ending position of this segment on each transcript.

Table 1651 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29. This segment can also be found in the following protein(s): T07775_P26, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_88 according to the present invention is supported by 116 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1652 below describes the starting and ending position of this segment on each transcript. Table 1652 - Segment location on transcripts

T07775 T21 5460 5726

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29. This segment can also be found in the following protein(s): T07775_P26, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_89 according to the present invention is supported by 187 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1653 below describes the starting and ending position of this segment on each transcript.

Table 1653 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_94 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1654 below describes the starting and ending position of this segment on each transcript.

Table 1654 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T07775_node_6 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T17. Table 1655 below describes the starting and ending position of this segment on each transcript.

Table 1655 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07775_P29.

Segment cluster T07775_node_8 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T18. Table 1656 below describes the starting and ending position of this segment on each transcript.

Table 1656 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07775_P29. Segment cluster T07775__node_13 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): TO7775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1657 below describes the starting and ending position of this segment on each transcript.

Table 1657 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775JP26.

Segment cluster T07775_node_14 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1658 below describes the starting and ending position of this segment on each transcript.

Table 1658 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775JP29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_26 according to the present invention is supported by 144 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1659 below describes the starting and ending position of this segment on each transcript.

Table 1659 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_29 according to the present invention is supported by 157 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1660 below describes the starting and ending position of this segment on each transcript.

Table 1660 - Segment location on transcripts

This segment can be found h both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775JP29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_31 according to the present invention is supported by 163 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1661 below describes the starting and ending position of this segment on each transcript.

Table 1661 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_33 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1662 below describes the starting and ending position of this segment on each transcript.

Table 1662 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775JP26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_36 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1663 below describes the starting and ending position of this segment on each transcript.

Table 1663 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_38 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1664 below describes the starting and ending position of this segment on each transcript.

Table 1664 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775JP26. This segment can also be found in the following protein(s): T07775JP29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_40 according to the present invention is supported by 141 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1665 below describes the starting and ending position of this segment on each transcript.

Table 1665 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_45 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1666 below describes the starting and ending position of this segment on each transcript.

Table 1666 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_50 according to the present invention can be found in the following transcript(s): T07775_T21. Table 1667 below describes the starting and ending position of this segment on each transcript. Table 1667 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26.

Segment cluster T07775_node_57 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1668 below describes the starting and ending position of this segment on each transcript.

Table 1668 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_58 according to the present invention is supported by 122 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1669 below describes the starting and ending position of this segment on each transcript.

Table 1669 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775JP26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_67 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1670 below describes the starting and ending positbn of this segment on each transcript.

Table 1670 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_69 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1671 below describes the starting and ending position of this segment on each transcript.

Table 1671 - Segment location on transcripts

I T07775 T21 | I 2669 I I 2672 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_70 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1672 below describes the starting and ending position of this segment on each transcript.

Table 1672 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P26. This segment can also be found in the following protein(s): T07775_P29, since it is in the coding region for the corresponding transcript.

Segment cluster T07775_node_76 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1673 below describes the starting and ending position of this segment on each transcript.

Table 1673 - Segment location on trarxscripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_77 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1674 below describes the starting and ending position of this segment on each transcript.

Table 1674 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_78 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1675 below describes the starting and ending position of this segment on each transcript.

Table 1675 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_79 according to the present invention is supported by 173 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_ T18 and T07775_T21. Table 1676 below describes the starting and ending position of this segment on each transcript.

Table 1676 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_80 according to the present invention is supported by 165 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, TO7775_T18 and T07775_T21. Table 1677 below describes the starting and ending position of this segment on each transcript.

Table 1677 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07775 JP29 and T07775_P26.

Segment cluster T07775_node_82 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1678 below describes the starting and ending position of this segment on each transcript.

Table 1678 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_83 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1679 below describes the starting and ending position of this segment on each transcript.

Table 1679 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_90 according to the present invention is supported by 136 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1680 below describes the starting and ending position of this segment on each transcript.

Table 1680 - Segment location on transcripts

I T07775 T21 | I 6182 j t 6296 I

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26.

Segment cluster T07775_node_91 according to the present invention can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1681 below describes the starting and ending position of this segment on each transcript.

Table 1681 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775JP26.

Segment cluster T07775_node_93 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07775_T16, T07775_T17, T07775_T18 and T07775_T21. Table 1682 below describes the starting and ending position of this segment on each transcript.

Table 1682 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07775_P29 and T07775_P26. DESCRIPTION FOR CLUSTER TO8538

Cluster T08538 features 3 transcript(s) and 24 segment(s) of interest, the names for which are given in Tables 1683 and 1684, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1685.

Table 1683 - Transcripts of interest

Transcript Name

T08538 T45

T08538 T56

T08538 T59

Table 1684 - Segments of interest

SegmentName

T08538 node 0

T08538 node 17

T08538 node 24

T08538 node 29

T08538 node 30

T08538 node 70

T08538 node 75

T08538 node 106

T08538 node 7

T08538 node 8

T08538 node 9

T08538 node 11

T08538 node 15

T08538 node 28

T08538 node 62

T08538 node 67

T08538 node 68

T08538 node 72

T08538 node 76

T08538 node 78

T08538 node 79

T08538 node 82

T08538 node 85

T08538 node 88 Table 1685 - Proteins of interest

Cluster T08538 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 44 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 44 and Table 1686. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: lung malignant tumors. Table 1686 - Normal tissue distribution

Table 1687 - P values and ratios for expression in cancerous tissue

As noted above, cluster T08538 features 24 segment(s), which were listed in Table 1684 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T08538_node_0 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T56 and T08538_T59. Table 1688 below describes the starting and ending position of this segment on each transcript.

Table 1688 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29 and T08538_P31.

Segment cluster T08538_node_17 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T56 and T08538_T59. Table 1689 below describes the starting and ending position of this segment on each transcript.

Table 1689 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29 and T08538JP31.

Segment cluster T08538_node_24 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T59. Table 1690 below describes the starting and ending position of this segment on each transcript.

Table 1690 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P31. Segment cluster T08538_node_29 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T56. Table 1691 below describes the starting and ending position of this segment on each transcript.

Table 1691 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29.

Segment cluster T08538_node_30 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T56. Table 1692 below describes the starting and ending position of this segment on each transcript.

Table 1692 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29.

Segment cluster T08538_node_70 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1693 below describes the starting and ending position of this segment on each transcript.

Table 1693 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23. Segment cluster T08538_node_75 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1694 below describes the starting and ending position of this segment on each transcript.

Table 1694 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

Segment cluster T08538_node_106 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1695 below describes the starting and ending position of this segment on each transcript.

Table 1695 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T08538_node_7 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T56 and T08538_T59. Table 1696 below describes the starting and ending position of this segment on each transcript.

Table 1696 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29 and T08538JP31.

Segment cluster T08538_node_8 according to the present invention can be found in the following transcript(s): T08538_T56 and T08538_T59. Table 1697 below describes the starting and ending position of this segment on each transcript.

Table 1697 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29 and T08538_P31.

Segment cluster T08538_node_9 according to the present invention can be found in the following transcript(s): T08538_T56 and T08538_T59. Table 1698 below describes the starting and ending position of this segment on each transcript.

Table 1698 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29 and T08538_P31.

Segment cluster T08538_node_l l according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T56 and T08538_T59. Table 1699 below describes the starting and ending position of this segment on each transcript.

Table 1699 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29 and T08538_P31.

Segment cluster T08538_node_ 15 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T56 and T08538_T59. Table 1700 below describes the starting and ending position of this segment on each transcript.

Table 1700 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29 and T08538JP31.

Segment cluster T08538_node_28 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T56. Table 1701 below describes the starting and ending position of this segment on each transcript.

Table 1701 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P29.

Segment cluster T08538_node_62 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1702 below describes the starting and ending position of this segment on each transcript. Table 1702 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T08538_P23.

Segment cluster T08538_node_67 according to the present invention can be found in the following transcript(s): T08538_T45. Table 1703 below describes the starting and ending position of this segment on each transcript.

Table 1703 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T08538JP23.

Segment cluster T08538_node_68 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1704 below describes the starting and ending position of this segment on each transcript.

Table 1704 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T08538_P23.

Segment cluster T08538_node_72 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1705 below describes the starting and ending position of this segment on each transcript.

Table 1705 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

Segment cluster T08538_node_76 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1706 below describes the starting and ending position of this segment on each transcript.

Table 1706 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

Segment cluster T08538_node_78 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1707 below describes the starting and ending position of this segment on each transcript.

Table 1707 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

Segment cluster T08538_node_79 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1708 below describes the starting and ending position of this segment on each transcript.

Table 1708 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

Segment cluster T08538_node_82 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1709 below describes the starting and ending position of this segment on each transcript.

Table 1709 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

Segment cluster T08538_node_85 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1710 below describes the starting and ending position of this segment on each transcript.

Table 1710 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

Segment cluster T08538_node_88 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T08538_T45. Table 1711 below describes the starting and ending position of this segment on each transcript.

Table 1711 - Segment location on transcripts

This segment can be found in the following protein(s): T08538_P23.

DESCRIPTION FOR CLUSTER T 10476

Cluster Tl 0476 features 10 transcript(s) and 61 segment(s) of interest, the names for which are given in Tables 1712 and 1713, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1714.

Table 1712 - Transcripts of interest

Transcript Name

T10476 T3

T10476 T4

T10476 T6

T10476 T7

Tl 0476 T8

Tl 0476 T13

Tl 0476. _T26

Tl 0476 T27

Tl 0476 T29

Tl 0476 T31

Table 1713 - Segments of interest

Segment Name

Tl 0476 node 0

Tl 0476 node 3

Tl 0476 node 13

Tl 0476 node 19

T10476 node 23 Tl0476 node 71

Tl0476 node 75

Tl0476 node 83

T10476 node 85

Tl0476 node 88

Tl0476 node 89

Tl0476 node 94

Tl0476 node 99

Tl0476 node 101

Tl0476 node 102

Tl0476 node 108

T10476 node 116

Table 1714 - Proteins of interest

Cluster T 10476 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 45 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 45 and Table 1715. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: colorectal cancer.

Table 1715 - Normal tissue distribution

Table 1716 - P values and ratios for expression in cancerous tissue

As noted above, cluster T 10476 features 61 segment(s), which were listed in Table 1713 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T10476_node_0 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1717 below describes the starting and ending position of this segment on each transcript.

Table 1717 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_3 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1718 below describes the starting and ending position of this segment on each transcript.

Table 1718 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476 P18.

Segment cluster T10476_jαode_13 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1719 below describes the starting and ending position of this segment on each transcript.

Table 1719 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476J^>9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_19 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1720 below describes the starting and ending position of this segment on each transcript.

Table 1720 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_23 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7,

T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1721 below describes the starting and ending position of this segment on each transcript.

Table 1721 - Segment location on transcripts

This segment can be found in the following protein(s): T10476JP4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_25 according to the present invention is supported by 5 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1722 below describes the starting and ending position of this segment on each transcript.

Table 1722 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476JP5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_31 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1723 below describes the starting and ending position of this segment on each transcript. Table 1723 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_39 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1724 below describes the starting and ending position of this segment on each transcript.

Table 1724 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_41 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1725 below describes the starting and ending position of this segment on each transcript.

Table 1725 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476JP7, T10476_P8, T10476JP9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_54 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T31. Table 1726 below describes the starting and ending position of this segment on each transcript.

Table 1726 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P18.

Segment cluster T10476_node_60 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1727 below describes the starting and ending position of this segment on each transcript.

Table 1727 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4. This segment can also be found in the following protein(s): T10476_P5, T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_62 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1728 below describes the starting and ending position of this segment on each transcript.

Table 1728 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4. This segment can also be found in the following protein(s): T10476_P5, T10476_P7, T10476_P8, T10476_P9 and T10476JP17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_64 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1729 below describes the starting and ending position of this segment on each transcript.

Table 1729 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4. This segment can also be found in the following protein(s): T10476_P5, T10476JP7, T10476JP8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_68 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1730 below describes the starting and ending position of this segment on each transcript.

Table 1730 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476 P4. This segment can also be found in the following protein(s): T10476_P5, T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_73 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1731 bebw describes the starting and ending position of this segment on each transcript.

Table 1731 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4. This segment can also be found in the following protein(s): T10476_P5, T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript. Segment cluster T10476_node_74 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T4. Table 1732 below describes the starting and ending position of this segment on each transcript.

Table 1732 - Segment location on transcripts

This segment can be found in the following protein(s): T10476JP5.

Segment cluster T10476_node_78 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1733 below describes the starting and ending position of this segment on each transcript.

Table 1733 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4 and T10476_P5. This segment can also be found in the following protein(s): T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript. Segment cluster T10476_node_80 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1734 below describes the starting and ending position of this segment on each transcript.

Table 1734 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4 and T10476_P5. This segment can also be found in the following protein(s): T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_90 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found h the following transcript(s): T10476_T7. Table 1735 below describes the starting and ending position of this segment on each transcript.

Table 1735 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P8. Segment cluster T10476_node_91 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1736 below describes the starting and ending position of this segment on each transcript.

Table 1736 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7 and T10476_P8. This segment can also be found in the following protein(s): T10476_P9 and T10476JP17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_98 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7,

T10476_T8, T10476_T13 and T10476_T29. Table 1737 below describes the starting and ending position of this segment on each transcript.

Table 1737 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476JP4, T10476_P5, T10476_P7 and T10476_P8. This segment can also be found in the following protein(s): T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_103 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T29. Table 1738 below describes the starting and ending position of this segment on each transcript.

Table 1738 - Segment location on transcripts

This segment can be found in the following protein(s): T10476 P17.

Segment cluster T10476_node_106 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T8 and T10476_T13. Table 1739 below describes the starting and ending position of this segment on each transcript.

Table 1739 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P9. Segment cluster T10476_node_107 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8 and T10476_T13. Table 1740 below describes the starting and ending position of this segment on each transcript.

Table 1740 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476J^>7, T10476_P8 and T10476_P9.

Segment cluster T10476_node_110 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T26 and T10476_T27. Table 1741 below describes the starting and ending position of this segment on each transcript.

Table 1741 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T10476_node_lll according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T26 and T10476_T27. Table 1742 below describes the starting and ending position of this segment on each transcript.

Table 1742 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476JP8 and T10476_P9.

Segment cluster T10476_node_114 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T26 and T10476_T27. Table 1743 below describes the starting and ending position of this segment on each transcript.

Table 1743 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8 and T10476_P9. Segment cluster T10476_node_115 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T27. Table 1744 below describes the starting and ending position of this segment on each transcript.

Table 1744 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T10476_node_l 17 according to the present invention is supported by 162 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T26 and T10476_T27. Table 1745 below describes the starting and ending position of this segment on each transcript. Table 1745 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8 and T10476_P9.

Segment cluster T10476_node_l 18 according to the present invention is supported by 145 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T26 and T10476_T27. Table 1746 below describes the starting and ending position of this segment on each transcript.

Table 1746 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8 and T10476_P9.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T10476_node_5 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7,

T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1747 below describes the starting and ending position of this segment on each transcript.

Table 1747 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476JP5, T10476_P7, T10476_P8, T10476JP9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_l l according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1748 below describes the starting and ending position of this segment on each transcript.

Table 1748 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_15 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1749 below describes the starting and ending position of this segment on each transcript.

Table 1749 - Segment location on transcripts

This segment can be found in the following protein(s): T10476JP4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_17 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1750 below describes the starting and ending position of this segment on each transcript.

Table 1750 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_21 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1751 below describes the starting and ending position of this segment on each transcript.

Table 1751 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5,

T10476_P7, T10476_P8, T10476_P9, T10476 P17 and T10476_P18.

Segment cluster T10476_node_27 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1752 below describes the starting and ending position of this segment on each transcript.

Table 1752 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5,

T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18. Segment cluster T10476_node_29 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1753 below describes the starting and ending position of this segment on each transcript.

Table 1753 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476JP9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_33 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1754 below describes the starting and ending position of this segment on each transcript.

Table 1754 - Segment location on transcripts

This segment can be found in the following protein(s): T10476 P4, T10476_P5, T10476JP7, T10476_P8, T10476J^>9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_35 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1755 below describes the starting and ending position of this segment on each transcript. Table 1755 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_37 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1756 below describes the starting and ending position of this segment on each transcript.

Table 1756 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476JP7, T10476JP8, T10476_P9, T10476_P17 and T10476JP18.

Segment cluster T10476_node_43 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1757 below describes the starting and ending position of this segment on each transcript.

Table 1757 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476JP8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_47 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1758 below describes the starting and ending position of this segment on each transcript.

Table 1758 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5,

T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_49 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the^" following transcript(s): T10476_T3, T10476_T4, T10476_T6,-T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1759 below describes the starting and ending position of this segment on each transcript.

Table 1759 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5,

T10476_P7, T10476_P8, T10476_P9, T10476JP17 and T10476_P18. Segment cluster T10476_node_51 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1760 below describes the starting and ending position of this segment on each transcript.

Table 1760 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476JP5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_53 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T29 and T10476_T31. Table 1761 below describes the starting and ending position of this segment on each transcript.

Table 1761 - Segment location on transcripts

This segment can be found in the following protein(s): T10476JP4, T10476JP5, T10476_P7, T10476_P8, T10476_P9, T10476_P17 and T10476_P18.

Segment cluster T10476_node_56 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1762 below describes the starting and ending position of this segment on each transcript. Table 1762 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8, T10476_P9 and T10476_P17.

Segment cluster T10476_node_57 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3. Table 1763 below describes the starting and ending position of this segment on each transcript.

Table 1763 - Segment location on transcripts

This segment can be found in the following protein(s): T10476_P4. Segment cluster T10476_jiode_58 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1764 below describes the starting and ending position of this segment on each transcript.

Table 1764 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476 P4. This segment can also be found in the following protein(s):

T10476_P5, T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_66 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476J4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1765 below describes the starting and ending position of this segment on each transcript. Table 1765 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476JP4. This segment can also be found in the following protein(s): T10476_P5, T10476_P7, T10476_P8, T10476_P9 and T10476JP17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_71 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1766 below describes the starting and ending position of this segment on each transcript.

Table 1766 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4. This segment can also be found in the following protein(s): T10476_P5, T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_75 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1767 below describes the starting and ending position of this segment on each transcript.

Table 1767 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476 P4 and T10476_P5. This segment can also be found in the following protein(s): T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_83 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1768 below describes the starting and ending position of this segment on each transcript.

Table 1768 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4 and T10476_P5. This segment can also be found in the following protein(s): T10476_P7, T10476JP8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_85 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1769 below describes the starting and ending position of this segment on each transcript.

Table 1769 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcriρt(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4 and T10476_P5. This segment can also be found in the following protein(s): T10476_P7, T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_88 according to the present invention can be found in the following transcriρt(s): T10476_T3, T10476_T4, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1770 below describes the starting and ending position of this segment on each transcript. Table 1770 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476JP4 and T10476JP5. This segment can also be found in the following protein(s): T10476_P8, T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_89 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found_in _the_/ollowing_transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7,_ T10476_T8, T10476_T13 and T10476_T29. Table 1771 below describes the starting and ending position of this segment on each transcript.

Table 1771 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4 and T10476 P5. This segment can also be found in the following protein(s): T10476_P7, T10476_P8, T10476_P9 and T10476JP17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_94 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1772 below describes the starting and ending position of this segment on each transcript.

Table 1772 - Segment location on transcripts

__

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7 and T10476_P8. This segment can also be found in the following protein(s): T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_99 according to the present invention can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1773 below describes the starting and ending position of this segment on each transcript.

Table 1773 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7 and T10476_P8. This segment can also be found in the following protein(s): T10476_P9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_101 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1774 below describes the starting and ending position of this segment on each transcript.

Table 1774 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7 and T10476_P8. This segment can also be found in the following protein(s): T10476_P9 and T10476JP17, since it is in the coding region for the corresponding transcript. Segment cluster T10476_node_102 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13 and T10476_T29. Table 1775 below describes the starting and ending position of this segment on each transcript.

Table 1775 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7 and T10476_P8. This segment can also be found in the following protein(s): T10476JP9 and T10476_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T10476_node_108 according to the present invention can be found in the following transcript(s): T10476_T13. Table 1776 below describes the starting and ending position of this segment on each transcript.

Table 1776 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10476_P9. Segment cluster T10476_node_116 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10476_T3, T10476_T4, T10476_T6, T10476_T7, T10476_T8, T10476_T13, T10476_T26 and T10476_T27. Table 1777 below describes the starting and ending position of this segment on each transcript.

Table 1777 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T10476_P4, T10476_P5, T10476_P7, T10476_P8 and T10476_P9.

DESCRIPTION FOR CLUSTER T49823

Cluster T49823 features 2 transcript(s) and 25 segment(s) of interest, the names for which are given in Tables 1778 and 1779, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1780.

Table 1778 - Transcripts of interest

Transcript Name

T49823 T41

T49823 T62

Table 1779 - Segments of interest

Table 1780 - Proteins of interest

Cluster T49823 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 46 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 46 and Table 1781. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and skin malignancies.

Table 4 - Normal tissue distribution

Table 1781 - P values and ratios for expression in cancerous tissue

As noted above, cluster T49823 features 25 segment(s), which were listed in Table 1779 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T49823_node_l 1 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41 and T49823_T62. Table 1783 below describes the starting and ending position of this segment on each transcript.

Table 1782 - Segment location on transcripts - - —

This segment can be found in the following protein(s): T49823_P6 and T49823_P34.

Segment cluster T49823_node_20 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41 and T49823_T62. Table 1784 below describes the starting and ending position of this segment on each transcript.

Table 1783 - Segment location on transcripts

I T49823 T62 I 362 I I 502 I

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T49823_P34. This segment can also be found in the following protein(s): T49823_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T49823_node_26 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T62. Table 1785 below describes the starting and ending position of this segment on each transcript.

Table 1784 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T49823_P34.

Segment cluster T49823_node_30 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1786 below describes the starting and ending position of this segment on each transcript. Table 1785 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_35 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be 02438

1085 found in the following transcript(s): T49823_T41. Table 1787 below describes the starting and ending position of this segment on each transcript.

Table 1786 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_38 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1788 below describes the starting and ending position of this segment on each transcript.

Table 1787 - Segment location on transcripts

This segment can be found in the following protein(s): T49823JP6.

Segment cluster T49823_node_56 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1789 below describes the starting and ending position of this segment on each transcript.

Table 1788 - Segment location on transcripts

This segment can be found in the following protein(s): T49823JP6.

Segment cluster T49823_node_57 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1790 below describes the starting and ending position of this segment on each transcript.

Table 1789 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T49823_node_4 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41 and T49823_T62. Table 1791 below describes the starting and ending position of this segment on each transcript. ^"

Table 1790 - Segment location on transcripts

This segment can be found in the following protein(s): T49823JP6 and T49823_P34.

Segment cluster T49823_node_12 according to the present invention can be found in the following transcript(s): T49823_T62. Table 1792 below describes the starting and ending position of this segment on each transcript.

Table 1791 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P34.

Segment cluster T49823_node_13 according to the present invention can be found in the following transcript(s): T49823_T62. Table 1793 below describes the starting and ending position of this segment on each transcript.

Table 1792 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P34.

Segment cluster T49823_node_16 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41 and T49823_T62. Table 1794 below describes the starting and ending position of this segment on each transcript.

Table 1793 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6 and T49823_P34.

Segment cluster T49823_node_17 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41 and T49823_T62. Table 1795 below describes the starting and ending position of this segment on each transcript.

Table 1794 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T49823_P34. This segment can also be found in the following protein(s): T49823_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T49823_node_19 according to the present invention can be found in the following transcript(s): T49823_T41 and T49823_T62. Table 1796 below describes the starting and ending position of this segment on each transcript. Table 1795 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as — follows. The segment can be found in a-non-coding region of transcript(s) that- are related to the following protein(s): T49823_P34. This segment can also be found in the following protein(s): T49823_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T49823_node_21 according to the present invention can be found in the following transcript(s): T49823_T41 and T49823_T62. Table 1797 below describes the starting and ending position of this segment on each transcript. Table 1796 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T49823_P34. This segment can also be found in the following protein(s): T49823_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T49823_node_22 according to the present invention can be found in the following transcript(s): T49823_T41 and T49823_T62. Table 1798 below describes the starting and ending position of this segment on each transcript.

Table 1797 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T49823_P34. This segment can also be found in the following protein(s): T49823_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T49823_node_28 according to the present hvention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1799 below describes the starting and ending position of this segment on each transcript.

Table 1798 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_31 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1800 below describes the starting and ending position of this segment on each transcript. Table 1799 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_37 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1801 below describes the starting and ending position of this segment on each transcript.

Table 1800 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_40 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1802 below describes the starting and ending position of this segment on each transcript.

Table 1801 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_41 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1803 below describes the starting and ending position of this segment on each transcript. Table 1802 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_44 according to the present invention can be found in the following transcript(s): T49823_T41. Table 1804 below describes the starting and ending position of this segment on each transcript.

Table 1803 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_45 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1805 below describes the starting and ending position of this segment on each transcript.

Table 1804 - Segment location on transcripts

This segment can be found in the following protein(s): T49823_P6.

Segment cluster T49823_node_50 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1806 below describes the starting and ending position of this segment on each transcript. Table 1805 - Segment location on transcripts

This segment can be found in the following protein(s): T49823 JP6.

Segment cluster T49823_node_58 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T49823_T41. Table 1807 below describes the starting and ending position of this segment on each transcript.

Table 1806 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T49823_P6.

DESCRIPTION FOR CLUSTER T51634

Cluster T51634 features 3 transcript(s) and 30 segment(s) of interest, the names for which are given in Tables 1807 and 1808, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1809.

Table 1807 - Transcripts of interest

Transcript Name

T51634 T4

T51634 TIl

T51634 Tl 8

Table 1808 - Segments of interest

Table 1809 - Proteins of interest

These sequences are variants of the known protein Restricted expression proliferation associated protein 100 (SwissProt accession identifier DIL2_HUMAN; known also according to the synonyms plOO; Differentially expressed in lung cells 2; OYL-2; Targeting protein for Xklp2; Protein FLS353; Hepatocellular carcinoma-associated antigen 519), referred to herein as the previously known protein.

The sequence for protein Restricted expression proliferation associated protein 100 is given at the end of the application, as "Restricted expression proliferation associated protein 100 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 1810.

Table 1810 - Amino acid mutations for Known Protein

Protein Restricted expression proliferation associated protein 100 localization is believed to be Nuclear. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: mitosis; cell proliferation, which are annotation(s) related to Biological Process; ATP binding; GTP binding, which are annotation(s) related to Molecular Function; and nucleus; spindle, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nbn.nih.gov/projects/LocusLink/>.

Cluster T51634 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 47 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 47 and Table 1811. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, hepatocellular carcinoma, lung malignant tumors, myosarcoma, pancreas carcinoma, skin malignancies, gastric carcinoma and uterine malignancies.

47

Table 1811 - Normal tissue distribution

Table 1812 - P values and ratios for expression in cancerous tissue

As noted above, cluster T51634 features 30 segment(s), which were listed in Table 1808 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T51634_node_l according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4. Table 1813 below describes the starting and ending position of this segment on each transcript. Table 1813 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T51634JP1.

Segment cluster T51634_node_3 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4. Table 1814 below describes the starting and ending position of this segment on each transcript.

Table 1814 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P1.

Segment cluster T51634_node_7 according to the present invention is supported by 2 libraries. The number of libraries-was determined as previously described- This segment can be- found in the following transcript(s): T51634_T4. Table 1815 below describes the starting and ending position of this segment on each transcript.

Table 1815 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P1.

Segment cluster T51634_node_9 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4. Table 1816 below describes the starting and ending position of this segment on each transcript. Table 1816 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1.

Segment cluster T51634_node_l l according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T11. Table 1817 below describes the starting and ending position of this segment on each transcript.

Table 1817 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P3.

Segment cluster T51634_node_12 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1818 below describes the starting and ending position of this segment on each transcript.

Table 1818 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P3. This segment can also be found in the following protein(s): T51634_P1, since it is in the coding region for the corresponding transcript. Segment cluster T51634_node_l 8 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1819 below describes the starting and ending position of this segment on each transcript.

Table 1819 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_25 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1820 below describes the starting and ending position of this segment on each transcript.

^~Tadle^~1820 ^'- Segment location^'on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634JP3.

Segment cluster T51634_node_27 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1821 below describes the starting and ending position of this segment on each transcript.

Table 1821 - Segment location on transcripts

T51634 T11 762 913

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_29 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1822 below describes the starting and ending position of this segment on each transcript.

Table 1822 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_33 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following tranlcript(s): T51634_T4 and^"T51634_Tll. Table 1823 below describes the starting and ending position of this segment on each transcript.

Table 1823 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_35 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1824 below describes the starting and ending position of this segment on each transcript.

Table 1824 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_40 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T18. Table 1825 below describes the starting and ending position of this segment on each transcript.

Table 1825 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P10.

Segment cluster T51634_node_43 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4, T51634_T11 and T51634_T18. Table 1826 below describes the starting and ending position of this segment on each transcript.

Table 1826 - Segment location on transcripts

This segment can be found in the following protein(s): T51634JP1, T51634 P3 and T51634 PlO. Segment cluster T51634_node_45 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4, T51634_T1 1 and T51634_T18. Table 1827 below describes the starting and ending position of this segment on each transcript.

Table 1827 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1, T51634_P3 and T51634_P10.

Segment cluster T51634_node_52 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1828 below describes the starting and ending position of this segment on each transcript.

Table 1828 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_54 according to the present invention is supported by 135 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1829 below describes the starting and ending position of this segment on each transcript.

Table 1829 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_56 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1830 below describes the starting and ending position of this segment on each transcript.

Table 1830 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P1 and T51634_P3.

Segment -cluster- T51634_node_59 according -to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1831 below describes the starting and ending position of this segment on each transcript.

Table 1831 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T51634_P1 and T51634_P3. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T51634_node_2 according to the present invention can be found in the following transcript(s): T51634_T4. Table 1832 below describes the starting and ending position of this segment on each transcript.

Table 1832 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P1.

Segment cluster T51634_node_5 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in theTollόwiήg transcripT(s): T51634_T4. Table^~1833^"below describesTHe starting ^"ancT ending position of this segment on each transcript.

Table 1833 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T51634JP1.

Segment cluster T51634_node_14 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1834 below describes the starting and ending position of this segment on each transcript.

Table 1834 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P3. This segment can also be found in the following protein(s): T51634_P1, since it is in the coding region for the corresponding transcript.

Segment cluster T51634_node_15 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1835 below describes the starting and ending position of this segment on each transcript.

Table 1835 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634_P3. This segment can also be found in the following protein(s): T51634JP1, since it is in the coding region for the corresponding transcript.

Segment cluster T51634_node_22 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1836 below describes the starting and ending position of this segment on each transcript.

Table 1836 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_23 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1837 below describes the starting and ending position of this segment on each transcript.

Table 1837 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3.

Segment cluster T51634_node_41 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be ?ound^~inΕe^~following^~¥ansmρt(s):T5l63^~43¹47T51634jTl l andrT51634jri8. Table^" 1838 below describes the starting and ending position of this segment on each transcript.

Table 1838 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1, T51634_P3 and T51634_P10.

Segment cluster T51634_node_46 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): T51634_T18. Table 1839 below describes the starting and ending position of this segment on each transcript.

Table 1839 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P10.

Segment cluster T51634_node_48 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1840 below describes the starting and ending position of this segment on each transcript.

Table 1840 - Segment location on transcripts

This segment can be found in the following protein(s): T51634JP1 and T51634_P3.

Segment cluster T51634_node_51 according to the present invention can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1841 below describes the starting and ending position of this segment on each transcript.

Table 1841 - Segment location on transcripts

This segment can be found in the following protein(s): T51634_P1 and T51634_P3. Segment cluster T51634_node_57 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T51634_T4 and T51634_T11. Table 1842 below describes the starting and ending position of this segment on each transcript.

Table 1842 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T51634JP1 and T51634JP3.

DESCRIPTION FOR CLUSTER T55968

Cluster T55968 features 5 transcript(s) and 14 segment(s) of interest, the names for which are given in Tables 1843 -and 1844, respectively,-the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1845.

Table 1843 - Transcripts of interest

Transcript Name

T55968 T3

T55968 T6

T55968 T7

T55968 TI l

T55968 T12

Table 1844 - Segments of interest

Segment Name

T55968 node 0

T55968 node 1

T55968 node 4

T55968 node 10

T55968 node 14 T55968 node 2

T55968 node 3

T55968 node 6

T55968 node 7

T55968 node 8

T55968 node 9

T55968 node 11

T55968 node 12

T55968 node 13

Table 1845 - Proteins of interest

These sequences are variants of the known protein 28S ribosomal protein S12, mitochondrial precursor (SwissProt accession identifier RT12_HUMAN; known also according to the synonyms MPR-S12; MT- RPS12), referred to herein as the previously known protein.

The sequence for protein 28S ribosomal protein S12, mitochondrial precursor is given at the end of the application, as "28S ribosomal protein S 12, mitochondrial precursor amino acid sequence". Protein 28S ribosomal protein S12, mitochondrial precursor localization is believed to be Mitocho ndrial.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein biosynthesis, which are annotation(s) related to Biological

Process; structural protein of ribosome, which are annotation(s) related to Molecular Function; and intracellular; mitochondrion; mitochondrial ribosome; small ribosomal subunit, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>. Cluster T55968 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 48 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 48 and Table 1846. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, pancreas carcinoma and skin malignancies.

48

Table 1846 -Normal tissue distribution

Table 1847 - P values and ratios for expression in cancerous tissue

As noted above, cluster T55968 features 14 segment(s), which were listed in Table 1844 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T55968_node_0 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T6, T55968_T7, T55968_T11 and T55968_T12. Table 1848 below describes the starting and ending position of this segment on each transcript.

Table 1848 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T55968JP1.

Segment cluster T55968_node_l according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T7 and T55968_T11. Table 1849 below describes the starting and ending position of this segment on each transcript.

Table 1849 - Segment location on transcripts

-This segment-can-be found in -aτκ>rFCθdingτegion^"θf transcript(s) that are related to the following protein(s): T55968_P1.

Segment cluster T55968_node_4 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T11 and T55968_T12. Table 1850 below describes the starting and ending position of this segment on each transcript.

Table 1850 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster T55968_node_10 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T6 and T55968_T7. Table 1851 below describes the starting and ending position of this segment on each transcript.

Table 1851 - Segment location on transcripts

This segment can be found in the following protein(s): T55968_P1.

Segment cluster T55968_node_14 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T6 and T55968_T7. Table 1852 below describes the starting and ending position of this segment on each transcript. Table 1852 - Segment locatiotuon transcripts —

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T55968_P1.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster T55968jnode_2 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T7 and T55968_T11. Table 1853 below describes the starting and ending position of this segment on each transcript.

Table 1853 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T55968_P1.

Segment cluster T55968_node_3 according to the present invention is supported by 95 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T6, T55968_T7, T55968_T11 and T55968_T12. Table 1854 below describes the starting and ending position of this segment on each transcript. - Table 1854 - Segment location on transcripts

This segment can be found in the following protein(s): T55968_P1.

Segment cluster T55968_node_6 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T6 and T55968_T7. Table 1855 below describes the starting and ending position of this segment on each transcript. Table 1855 - Segment location on transcripts

This segment can be found in the following protein(s): T55968_P1.

Segment cluster T55968_node_7 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T6 and T55968_T7. Table 1856 below describes the starting and ending position of this segment on each transcript.

Table 1856 - Segment location on transcripts

This segment can be found in the following protein(s): T55968_P1.

Segment cluster T55968_node_8 according to the present invention can be found in the following transcript(s): T55968_T3, T55968_T6 and T55968_T7. Table 1857 below describes the starting and ending position of this segment on each transcript.

Table 1857 - Segment location on transcripts

This segment can be found in the following protein(s): T55968_P1. Segment cluster T55968_node_9 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968__T6 and T55968_T7. Table 1858 below describes the starting and ending position of this segment on each transcript.

Table 1858 - Segment location on transcripts

This segment can be found in the following protein(s): T55968_P1.

Segment cluster T55968_node_l 1 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T6 and T55968_T7. Table 1859 below describes the starting and ending position of this segment on each transcript.

Table 1859 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T55968_P1.

Segment cluster T55968_node_12 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T55968_T3, T55968_T6 and T55968_T7. Table 1860 below describes the starting and ending position of this segment on each transcript.

Table 1860 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T55968_P1.

Segment cluster T55968_node_13 according to the present invention can be found in the following transcript(s): T55968_T3, T55968_T6 and T55968_T7. Table 1861 below describes the starting and ending position of this segment on each transcript.

Table 1861 - Segment location on transcripts

- -This segment -can be found in a non-coding region of transcript(s) that are related to the following protein(s): T55968_P1.

DESCRIPTION FOR CLUSTER T86235

Cluster T86235 features 34 transcript(s) and 47 segment(s) of interest, the names for which are given in Tables 1862 and 1863, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1864.

Table 1862 - Transcripts of interest

Transcript Name

T86235 Tl

T86235 T2

T86235 T3 T86235 T4

T86235 T5

T86235 T6

T86235 T7

T86235 T8

T86235 T9

T86235 TlO

T86235 T12

T86235 T13

T86235_. _T14

T86235 T15

T86235 T16

T86235 T18

T86235 T21

T86235 T22

T86235 T23

T86235 T24

T86235 T25

T86235 T26

T86235 T28

T86235 T29

T86235 T31

T86235 T32

T86235 T33

T86235 T34

T86235_. _T35

T86235 T36

T86235 T37

T86235 T38

T86235 T39

T86235 T40

Table1863-Segmentsofinterest

SegmentName

T86235 node 3

T86235 node 19

T86235 node 21

T86235 node 25

T86235 node 35

T86235 node 36

T86235 node 41

T86235 node 42

T86235 node 43 T86235 node 44

T86235 node 51

T86235 node 56

T86235 node 57

T86235 node 58

T86235 node 59

T86235 node 0

T86235 node 4

T86235 node 6

T86235 node 7

T86235 node 9

T86235 node 10

T86235 node 11

T86235 node 12

T86235 node 13

T86235 node 14

T86235 node 15

T86235 node 16

T86235 node 17

T86235 node 18

T86235 node 22

T86235 node 23

T86235 node 27

J86235.JiQde.29

T86235 node 31

T86235 node 32

T86235 node 33

T86235 node 38

T86235 node 40

T86235 node 45

T86235 node 46

T86235 node 47

T86235 node 48

T86235 node 49

T86235 node 50

T86235 node 52

T86235 node 54

T86235 node 55

Table1864-Proteinsofinterest

These sequences are variants of the known protein Trophinin- associated protein (SwissProt accession identifier TASTJHUMAN; known also according to the synonyms Tastin;

Trophinin-assisting protein), referred to herein as the previously known protein.

Protein Trophinin- associated protein is known or believed to have the following function(s): Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. The sequence for protein Trophinin- associated protein is given at the end of the application, as "Trophinin-associated protein amino acid sequence". Protein Trophinin- associated protein localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell adhesion, which are annotation(s) related to Biological Process; protein binding, which are annotation(s) related to Molecular Function; and cytoplasm, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster T86235 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 49 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 49 and Table 1865. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues and skin malignancies.

Table 1865 - Normal tissue distribution

Uterus

Table 1866 - P values and ratios for expression in cancerous tissue

As noted above, cluster T86235 features 47 segment(s), which were listed in Table 1863 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T86235_node_3 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T22, T86235_T23, T86235_T24, T86235_T25, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T34, T86235_T35, T86235_T36, T86235_T37, T86235_T39 and T86235_T40. Table 1867 below describes the starting and ending position of this segment on each transcript.

Table 1867 - Segment location on transcripts

T86235 T40 85 227

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P5,

T86235_P6, T86235JP7, T86235_P8, T86235_P10, T86235JP11, T86235JH, T86235_P12, T86235_P14, T86235_P15, T86235_P17, T86235_P18, T86235_P19, T86235_P20,

T86235 P21 and T86235 P22.

Segment cluster T86235__node_19 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T35, T86235_T36, T86235_T37 and T86235_T39. Table 1868 below describes the starting and ending position of this segment on each transcript.

Table 1868 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235JP18. This segment can also be found in the following protein(s): T86235_P15, T86235_P17, T86235_P20 and T86235JP21, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_21 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T38. Table 1869 below describes the starting and ending position of this segment on each transcript.

Table 1869 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T86235_node_25 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235__T16, T86235_T18, T86235_T21, T86235_T22, T86235_T23 and T86235_T24. Table 1870 below describes the starting and ending position of this segment on each transcript.

Table 1870 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcriρt(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11 and T86235JP1. This segment can also be found in the following protein(s): T86235_P28 and T86235_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_35 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T26. Table 1871 below describes the starting and ending position of this segment on each transcript.

Table 1871 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P7.

Segment cluster T86235_node_36 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235JU2, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T23, T86235_T24, T86235_T25, T86235_T26 and T86235_T34. Table 1872 below describes the starting and ending position of this segment on each transcript. Table 1872 - Segment location on transcripts

___ _This_segment . can..be .found _in. bpth_coding_and noik coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P7, T86235_P11 and T86235_P12. This segment can also be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P8, T86235_P10, T86235_P1 and T86235_P19, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_41 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following tran3cript(s): T86235_T7, T86235_T9, T86235_T13 and T86235_T26. Table 1873 below describes the starting and ending position of this segment on each transcript.

Table 1873 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T86235JP7 and T86235_P11.

Segment cluster T86235_node_42 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235JN, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T23, T86235_T24, T86235_T25, T86235_T26 and T86235_T34. Table 1874 below describes the starting and ending position of this segment on each transcript.

Table 1874 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P7, T86235_P11 and T86235_P12. This segment can also be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P8, T86235_P1 and T86235_P19, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_43 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s) : T86235_T8 and T86235_T9. Table 1875 below describes the starting and ending position of this segment on each transcript.

Table 1875 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P7.

Segment cluster T86235_node_44 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T23, T86235_T24, T86235_T25 and T86235_T26. Table 1876 below describes the starting and ending position of this segment on each transcript. Table 1876 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235JP2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235 PI l and T86235 Pl.

Segment cluster T86235_node_51 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T25 and T86235_T26. Table 1877 below describes the starting and ending position of this segment on each transcript.

Table 1877 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P6, T86235_P7, T86235_P10, T86235_P11 and T86235JP1.

Segment cluster T86235_node_56 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T3, T86235_T4, T86235_T13, T86235_T28 and T86235_T38. Table 1878 below describes the starting and ending position of this segment on each transcript.

Table 1878 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P3, T86235_P4, T86235 Pll and T86235 P14.

Segment cluster T86235_node_57 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T23, T86235_T24, T86235_T25, T86235_T26, T86235_T28, T86235_T34, T86235_T38 and T86235_T40. Table 1879 below describes the starting and ending position of this segment on each transcript.

Table 1879 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P12. This segment can also be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235JP5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235JP11, T86235_P1, T86235_P14, T86235_P19 and T86235_P22, since it is in the coding region for the corresponding transcript. Segment cluster T86235_node_58 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T4. Table 1880 below describes the starting and ending position of this segment on each transcript.

Table 1880 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1881.

Table 1881 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): T86235_P4.

Segment cluster T86235_node_59 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T23, T86235_T24, T86235_T25, T86235_T26, T86235_T28, T86235_T34, T86235_T38 and T86235_T40. Table 1882 below describes the starting and ending position of this segment on each transcript.

Table 1882 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P4, T86235_P5, T86235_P6, T86235_P8, T86235_P12 and T86235_P19. This segment can also be found in the following protein(s): T86235JP28, T86235_P2, T86235_P3, T86235_P7, T86235_P10, T86235_P11, T86235_P1, T86235_P14 and T86235_P22, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster T86235_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T22, T86235JI23, T86235_T24, T86235_T25, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T34, T86235_T35, T86235_T36, T86235_T37, T86235_T39 and T86235_T40. Table 1883 below describes the starting and ending position of this segment on each transcrip t.

Table 1883 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235J^>28, T86235_P2, T86235_P3, T86235_P4, T86235_P5,

T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235JP11, T86235JP1, T86235_P12, T86235_P14, T86235_P15, T86235_P17, T86235_P18, T86235JP19, T86235_P20,

T86235 P21 and T86235 P22.

Segment cluster T86235_node_4 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T22, T86235_T23, T86235_T24, T86235_T25, T86235_T28, T86235_T29, T86235_T31, -T86235_T32, -T86235_T33; — TS6235iT34,- T86235_T35,— T86235_T36, T86235_T37, T86235_T39 and T86235_T40. Table 1884 below describes the starting and ending position of this segment on each transcript.

Table 1884 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P5,

^" T8623TP6, ^"T86235 JP7, T86235_P8^~ T86235JP10,^" T86235_pfl, ^~ T^~86235_P1^~, ^~T86235JP12, T86235_P14, T86235_P15, T86235_P17, T86235_P18, T86235_P19, T86235JP20,

T86235 P21 and T86235 P22.

Segment cluster T86235_node_6 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T22, T86235_T23, T86235_T24, T86235_T25, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T34, T86235_T35, T86235_T36, T86235_T37, T86235_T39 and T86235_T40. Table 1885 below describes the starting and ending position of this segment on each transcript.

Table 1885 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235JP11, T86235JP1, T86235_P19 and

T86235_P22. This segment can also be found in the following protein(s): T86235_P28, T86235_P12, T86235_P14, T86235_P15, T86235_P17, T86235_P18, T86235_P20 and T86235_P21, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_7 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T22, T86235_T23, T86235_T24, T86235_T25, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T34, T86235_T35, T86235_T36, T86235_T37, T86235_T39 and T86235_T40. Table 1886 below describes the starting and ending position of this segment on each transcript.

Table 1886 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235JP8, T86235_P10, T86235_P11, T86235_P1, T86235_P19 and T86235_P22. This segment can also be found in the following protein(s): T86235_P28, T86235_P12, T86235_P14, T86235_P15, T86235_P17, T86235_P18, T86235_P20 and T86235_P21, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_9 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T22, T86235_T23, T86235_T24, T86235_T25, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T34, T86235_T35, T86235_T36, T86235_T37, T86235_T39 and T86235_T40. Table 1887 below describes the starting and ending position of this segment on each transcript.

Table 1887 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11, T86235_P1 and T86235_P19. This segment can also be found in the following protein(s): T86235_P28, T86235JP12, T86235_P14, T86235_P15, T86235_P17, T86235_P18, T86235JP20, T86235_P21 and T86235_P22, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_10 according to the present invention can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T22, T86235_T23, T86235_T24, T86235_T25, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T34, T86235_T35, T86235_T36, T86235_T37 and T86235_T39. Table 1888 below describes the starting and ending position of this segment on each transcript.

Table 1888 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235JP2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235JP7, T86235_P8, T86235_P10, T86235_P11, T86235_P1 and T86235_P19. This segment can also be found in the following protein(s): T86235_P28, T86235_P12, T86235_P14, T86235_P15, T86235_P17, T86235_P18, T86235_P20 and T86235_P21, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_ll according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T22, T86235_T23, T86235_T24, T86235_T25, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T34, T86235_T35, T86235_T36, T86235_T37 and T86235_T39. Table 1889 below describes the starting and ending position of this segment on each transcript.

Table 1889 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235_P4, T86235J^>5, T86235_P6, T86235_P7, T86235JP8, T86235_P10, T86235JP11, T86235_P1 and T86235_P19. This segment can also be found in the following protein(s): T86235_P28, T86235_P12, T86235_P14, T86235JP15, T86235_P17, T86235_P18, T86235_P20 and T86235JP21, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_12 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T16, T86235_T18, T86235_T22, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T35, T86235_T36 and T86235_T37. Table 1890 below describes the starting and ending position of this segment on each transcript.

Table 1890 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following^{" ~} protein(s):^~ T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11 and T86235_P1. This segment can also be found in the following protein(s): T86235_P28, T86235_P12, T86235_P14, T86235_P15, T86235_P17, T86235_P18 and T86235_P20, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_13 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T16, T86235_T18, T86235_T22, T86235_T28, T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T35, T86235_T36 and T86235_T37. Table 1891 below describes the starting and ending position of this segment on each transcript. Table 1891 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11 and T86235JP1. This segment can also be found in the following protein(s): T86235_P28, T86235_P12, T86235_P14, T86235_P15, T86235_P17, T86235_P18 and T86235_P20, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_14 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T33 and T86235_T37. Table 1892 below describes the starting and ending position of this segment on each transcript.

Table 1892 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1893.

Table 1893 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): T86235JP18.

Segment cluster T86235_node_15 according to the present invention can be found in the following transcript(s): T86235_T33 and T86235_T37. Table 1894 below describes the starting and ending position of this segment on each transcript.

Table 1894 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P18.

Segment cluster T86235_node_16 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T32, T86235_T33, T86235_T35 and T86235_T37. Table 1895 below describes the starting and ending position of this segment on each transcript.

Table 1895 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P18. This segment can also be found in the following protein(s): T86235_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_17 according to the present invention can be found in the following transcript(s): T86235_T32, T86235_T33, T86235_T35, T86235_T36 and T86235_T37. Table 1896 below describes the starting and ending position of this segment on each transcript.

Table 1896 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T86235_P18. This segment can also be found in the following protein(s): T86235_P17 and T86235_P20, since it is in the coding region for the corresponding transcript. Segment cluster T86235_node_18 according to the present invention can be found in the following transcript(s): T86235_T29, T86235_T31, T86235_T32, T86235_T33, T86235_T35, T86235_T36, T86235_T37 and T86235_T39. Table 1897 below describes the starting and ending position of this segment on each transcript.

Table 1897 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T86235_P18. This segment can also be found in the following protein(s): T86235_P15, T86235_P17, T86235JP20 and T86235JP21, -since it is in the coding region for - the corresponding transcript.

Segment cluster T86235_node_22 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T22, T86235_T23, T86235_T24, T86235_T28 and T86235_T38. Table 1898 below describes the starting and ending position of this segment on each transcript. Table 1898 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235JP2, T86235JP3, _T86235_P4, T86235_P5_i__T?6235_P6,_ T86235_P7, T86235_P8, T86235_P10, T86235_P11 and T86235JP1. This segment can also be found in the following protein(s): T86235_P28, T86235_P12 and T86235_P14, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_23 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4,

T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12,

T86235_T13, T86235JH4, T86235_T15, T86235_T16, T86235_T22, T86235_T23,

T86235_T24, T86235_T28 and T86235_T38. Table 1899 below describes the starting and ending position of this segment on each transcript.

Table 1899 - Segment location on transcripts

This^" segment can be-foxind-in-both coding- and non^coding τegions^~ofHxanscript(s)-as- follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235JP4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11 and T86235JP1. This segment can also be found in the following protein(s): T86235_P28, T86235JP12 and T86235_P14, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_27 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4,

T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12,

T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21,

T86235_T22, T86235_T23 and T86235_T24. Table 1900 below describes the starting and ending position of this segment on each transcript. Table 1900 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11 and T86235JP1. This segment can also be found in the following protein(s): T86235_P28 and T86235_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_29 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235JN, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T22, T86235_T23 and T86235_T24. Table 1901 below describes the starting and ending position of this segment on each transcript.

Table 1901 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235JP6, T86235_P7, T86235JP8, T86235_P10, T86235_P11 and T86235_P1. This segment can also be found in the following protein(s): T86235_P28 and T86235_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_31 according to the present invention can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5,

T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T22, T86235_T23 and T86235_T24. Table 1902 below describes the starting and ending position of this segment on each transcript.

Table 1902 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P2, T86235__P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11 and T86235_P1. This segment can also be found in the following protein(s): T86235_P28 and T86235_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_32 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12,

T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T22, T86235_T23, T86235_T24, T86235_T25 and T86235_T34. Table 1903 below describes the starting and ending position of this segment on each transcript.

Table 1903 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P7, T86235_P11 and T86235_P12. This segment can also be found in the following protein(s): T86235JP28, T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P8, T86235_P10, T86235_P1 and T86235_P19, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_33 according to the present invention can be found in the following transcript(s): T86235_T22. Table 1904 below describes the starting and ending position of this segment on each transcript. Table 1904 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P12.

Segment cluster T86235_node_38 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235__T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21, T86235_T23, T86235_T24, T86235_T25, T86235_T26 and T86235_T34. Table 1905 below describes the starting and ending position of this segment on each transcript.

Table 1905 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P7, T86235_P11 and T86235_P12. This segment can also be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P8, T86235JP10, T86235JP1 and T86235_P19, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_40 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4,

T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12,

T86235_T13, T86235_T14, T86235_T15, T86235_T16, T86235_T18, T86235_T21,

T86235_T23, T86235_T24, T86235_T25, T86235_T26 and T86235_T34. Table 1906 below describes the starting_and_ending position of this segment on each transcript.

Table 1906 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86235_P7, T86235_P11 and T86235_P12. This segment can also be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P8, T86235_P10, T86235_P1 and T86235JP19, since it is in the coding region for the corresponding transcript.

Segment cluster T86235_node_45 according to the present invention can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T23, T86235_T24,

T86235_T25 and T86235_T26. Table 1907 below describes the starting and ending position of this segment on each transcript.

Table 1907 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235JP3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235 PI l and T86235 Pl .

Segment cluster T86235_node_46 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T23, T86235_T24, T86235_T25 and T86235_T26. Table 1908 below describes the starting and ending position of this segment on each transcript.

Table 1908 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235JP8, T86235_P10, T86235 PI l and T86235 Pl.

Segment cluster T86235_node_47 according to the present invention is supported by 32 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T5, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T23, T86235_T24, T86235_T25 and T86235_T26. Table 1909 below describes the starting and ending position of this segment on each transcript.

Table 1909 - Segment location on transcripts

T86235 T26 1488 1533

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P5, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11 and T86235_Pl.

Segment cluster T86235_node_48 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T3, T86235_T4, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T25 and T86235_T26. Table 1910 below describes the starting and ending position of this segment on each transcript.

Table 1910 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P3, T86235_P4, T86235JP6, T86235_P7, T86235_P10, T86235_P11 and T86235JP1.

Segment cluster T86235_node_49 according to the present invention can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T12, T86235__T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T25 and T86235_T26. Table 1911 below describes toe starting and ending position of this segment on each transcript.

Table 1911 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P6, T86235_P7, T86235_P10, T86235_P11 and T86235JP1.

Segment cluster T86235_node_50 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T25 and T86235_T26. Table 1912 below describes the starting and ending position of this segment on each transcript. Table 1912 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P6, T86235_P7, T86235_P10, T86235JP11 and T86235_P1.

Segment cluster T86235_node_52 according to the present invention can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T6, -T86235_ZT7-T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14,- T86235_T15, T86235_T18, T86235_T21, T86235_T24, T86235_T25 and T86235_T26. Table 1913 below describes the starting and ending position of this segment on each transcript. Table 1913 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235JP6, T86235_P7, T86235_P8, T86235_P10, T86235J^>11 and T86235 Pl.

Segment cluster T86235_node_54 according to the present invention can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T6, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T24, T86235_T25, T86235_T26, T86235_T28 and T86235_T38. Table 1914 below describes the starting and ending position of this segment on each transcript.

Table 1914 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235_P6, T86235_P7, T86235_P8, T86235_P10, T86235_P11, T86235 Pl and T86235 P14.

Segment cluster T86235_node_55 according to the present invention can be found in the following transcript(s): T86235_T1, T86235_T2, T86235_T3, T86235_T4, T86235_T7, T86235_T8, T86235_T9, T86235_T10, T86235_T12, T86235_T13, T86235_T14, T86235_T15, T86235_T18, T86235_T21, T86235_T24, T86235_T25, T86235_T26, T86235_T28 and T86235_T38. Table 1915 below describes the starting and ending position of this segment on each transcript.

Table 1915 - Segment location on transcripts

This segment can be found in the following protein(s): T86235_P28, T86235_P2, T86235_P3, T86235_P4, T86235JP7, T86235_P8, T86235_P10, T86235_P11, T86235_P1 and T86235 P14.

DESCRIPTION FOR CLUSTER WO 1871

Cluster WOl 871 features 7 transcript(s) and 23 segment(s) of interest, the names for which are given in Tables 1916 and 1917, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1918.

Table 1916 - Transcripts of interest

Table 1917 - Segments of interest

Segment Name

WOl 871 node 0

WOl 871 node 1

W01871 node 37

W01871 node 40

W01871 node 42

W01871 node 47

W01871 node 52

WOl 871 node 3

WOl 871 node 7

W01871 node 9

WOl 871 node 11

W01871 node 13 WOl 871 node 14

WOl 871 node 18

WOl 871 node 21

WOl 871 node 24

WOl 871 node 25

WOl 871 node 27

WOl 871 node 30

W01871 node 32

W01871 node 35

WOl 871 node _44

W01871 node 49

Table 1918 - Proteins of interest

Cluster WO 1871 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 50 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 50 and Table 1919. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 1919 - Normal tissue distribution

Table 1920 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 1921.

Table 1921 - Oligonucleotides related to this cluster

As noted above, cluster WO 1871 features 23 segment(s), which were listed in Table 1917 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster W01871_node_0 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1922 below describes the starting and ending position of this segment on each transcript. Table 1922 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): W01871_P2, W01871JP1, W01871_P5, W01871_P7, W01871_P25 and W01871 P34.

Segment cluster W01871_node_l according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1923 below describes the starting and ending position of this segment on each transcript. Table 1923 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): W01871_P2, W01871JP1, W01871_P5, W01871_P7, W01871_P25 and W01871_P34.

Segment cluster W01871_node_37 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1924 below describes the starting and ending position of this segment on each transcript.

Table 1924 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, W01871JP1, W01871_P5, W01871_P7, W01871JP25 and W01871_P34.

Segment cluster W01871_node_40 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10 and W01871_T15. Table 1925 below describes the starting and ending position of this segment on each transcript.

Table 1925 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, WO1871_P1, W01871 P5 and W01871 P7.

Segment cluster W01871_node_42 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1926 below describes the starting and ending position of this segment on each transcript. Table 1926 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, W01871JP1, W01871_P5, W01871_P7, W01871_P25 and W01871_P34.

Segment cluster W01871_node_47 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1927 below describes the starting and ending position of this segment on each transcript.

Table 1927 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, WO1871_P1, W01871_P5, W01871_P7, W01871_P25 and W01871_P34.

Segment cluster W01871_node_52 according to the present invention is supported by 75 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1928 below describes the starting and ending position of this segment on each transcript.

Table 1928 - Segment location on transcripts

This segment can be found in the following protein(s): W01871JP2, WO1871_P1,

W01871_P5, W01871_P7, W01871_P25 and W01871_P34.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster W01871_node_3 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 14 below describes the starting and ending position of this segment on each transcript.

Table 1929 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): WO1871_P1, W01871_P5, W01871_P7, W01871_P25 and W01871_P34.

Segment cluster W01871_node_7 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1930 below describes the starting and ending position of this segment on each transcript.

Table 1930 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): W01871_P7. This segment can also be found in the following protein(s):

W01871_P2, W01871JP1, W01871_P5, W01871_P25 and W01871JP34, since it is in the coding region for the corresponding transcript.

Segment cluster W01871_node_9 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1931 below describes the starting and ending position of this segment on each transcript.

Table 1931 - Segment location on transcripts

This ssgment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): W01871_P7. This segment can also be found in the following protein(s): W01871JP1, W01871_P5, W01871_P25 and W01871_P34, since it is in the coding region for the corresponding transcript.

Segment cluster W01871_node_ll according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1932 below describes the starting and ending position of this segment on each transcript.

-Table 1932 - Segment location on transcripts-

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 1933.

Table 1933 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): W01871_P7. This segment can also be found in the following protein(s): W01871_P2, WO1871_P1, W01871_P5, W01871_P25 and W01871_P34, since it is in the coding region for the corresponding transcript.

Segment cluster W01871_node_13 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4 and W01871_T5. Table 1934 below describes the starting and ending position of this segment on each transcript.

Table 1934 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2 and WO1871_P1.

Segment cluster W01871_node_14 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4 and W01871_T5. Table 1935 below describes the starting and ending position of this segment on each transcript.

Table 1935 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2 and WO1871_P1. Segment cluster W01871_node_18 according to the present invention is supported by 48 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10 and W01871_T15. Table 1936 below describes the starting and ending position of this segment on each transcript.

Table 1936 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): W01871_P7. This segment can also be found in the following protein(s):

— W01871JP-2, WO1871_P1 and— W01871_zP5_r since- it -is— in the -coding - region -for-the corresponding transcript.

Segment cluster W01871_node_21 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10 and W01871_T15. Table 1937 below describes the starting and ending position of this segment on each transcript. Table 1937 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): W01871_P7. This segment can also be found in the following protein(s): W01871_P2, W01871JP1 and W01871_P5, since it is in the coding region for the corresponding transcript.

Segment cluster W01871_node_24 according to the present invention can be found in the following transcript(s): W01871_T15. Table 1938 below describes the starting and ending position of this segment on each transcript.

Table 1938 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): W01871_P7.

Segment cluster W01871_node_25 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T15. Table 1939 below describes the starting and ending position of this segment on each transcript. Table 1939 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): W01871_P7.

Segment cluster W01871_node_27 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10 and W01871_T15. Table 1940 below describes the starting and ending position of this segment on each transcript.

Table 1940 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, WO1871_P1, WO1871 P5 and W01871 P7.

Segment cluster W01871_node_30 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, -W0187-1-T-1-5,- W01871_T34 -and-W01871 -T4β.-T-able-1941-below~describes-the starting and ending position of this segment on each transcript.

Table 1941 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, WO1871_P1, W01871_P5, W01871_P7, W01871_P25 and W01871_P34. Segment cluster W01871_node_32 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1942 below describes the starting and ending position of this segment on each transcript.

Table 1942 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, W01871JP1, W01871_P5, W01871_P7, W01871_P25 and W01871_P34.

Segment cluster W01871_node_35 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1943 below describes the starting and ending position of this segment on each transcript.

Table 1943 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, WO 187 IJPl, W01871JP5, W01871_P7, W01871JP25 and W01871JP34.

Segment cluster W01871_node_44 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15, W01871_T34 and W01871_T43. Table 1944 below describes the starting and ending position of this segment on each transcript.

Table 1944 - Segment location on transcripts

This segment can be found in the following protein(s): W01871JP2, W01871JP1, W01871JP5, W01871JP7, W01871JP25 and W01871 JP34.

Segment cluster W01871_node_49 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W01871_T2, W01871_T4, W01871_T5, W01871_T10, W01871_T15 and W01871_T34. Table 1945 below describes the starting and ending position of this segment on each transcript.

Table 1945 - Segment location on transcripts

This segment can be found in the following protein(s): W01871_P2, WO1871_P1, W01871_P5, W01871_P7 and WO1871_P25.

DESCRIPTION FOR CLUSTER Z19204

Cluster Zl 9204 features 6 transcript(s) and 49 segment(s) of interest, the names for which are given in Tables 1946 and 1947, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 1948.

Table 1946- Transcripts of interest

TranscriptName

Zl9204 T27

Zl9204 T29

Zl9204 T30

Zl9204 T31

Z19204 T34

Zl9204 T42

Table 1947 - Segments of interest

SegmentName

Zl9204 node 0

Zl9204 node 1

Zl9204 node 2

Zl9204 node 4

Zl9204 node 17

Z19204 node 49

Zl9204 node 50

Zl9204 node 58 Zl9204 node 63

Zl9204 node 64

Zl9204 node 65

Zl9204 node 75

Zl9204 node 18

Z19204 node 19

Zl9204 node 20

Zl9204 node 21

Zl9204 node 22

Zl9204 node_ 23

Z19204 node 25

Zl9204 node 26

Zl9204 node 27

Zl9204 node 28

Zl9204 node 29

Zl9204 node 30

Zl9204 node 31

Z19204 node 32

Zl9204 node 34

Zl9204 node 35

Zl9204 node 36

Zl9204 node 40

Z19204 node 48

Zl9204 node_51

Zl9204 node 52

Zl9204 node 53

Z19204 node 54

Zl9204 node 55

Zl9204 node 56

Zl9204 node 57

Zl9204 node 59

Z19204 node 60

Zl9204 node 61

Zl9204 node 62

Z19204 node 66

Zl9204 node 61

Zl9204 node 68

Zl9204 node 69

Zl9204 node 70

Zl9204 node 73

Zl9204 node 74

Table 1948 - Proteins of interest

These sequences are variants of the known protein Cold- inducible RNA-binding protein (SwissProt accession identifier CIRP_HUMAN; known also according to the synonyms Glycine-rich RNA-binding protein CIRP; Al 8 hnRNP), referred to herein as the previously known protein.

Protein Cold-inducible RNA-binding protein is known or believed to have the following function(s): Seems to play an essential role in cold- induced suppression of cell proliferation. The sequence for protein Cold-inducible RNA-binding protein is given at the end of the application, as "Cold-inducible RNA-binding protein amino acid sequence". Protein CoId- inducible RNA-binding protein localization is believed to be Nuclear; nucleoplasm (By similarity).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: response to cold, which are annotations) related to Biological Process; RNA binding, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster Z19204 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 51 refer to weighted expression of ESTs ή each categoiy, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 51 and Table 1949. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: breast malignant tumors. 51

Table 1949 - Normal tissue distribution

Table 1950 - P values and ratios for expression in cancerous tissue

As noted above, cluster Zl 9204 features 49 segment(s), which were listed in Table 1947 above and for which the ssquence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z19204_node_0 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T29, Z19204_T30, Z19204_T31 and Z19204_T34. Table 1951 below describes the starting and ending position of this segment on each transcript. Table 1951 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1. This segment can also be found in the following protein(s): Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_l according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T29 and Z19204_T30. Table 1952 below describes the starting and ending position of this segment on each transcript.

Table 1952 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Zl 9204 JPl.

Segment cluster Z19204_node_2 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T29. Table 1953 below describes the starting and ending position of this segment on each transcript. Table 1953 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1. Segment cluster Z19204_node_4 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T29 and Z19204_T31. Table 1954 below describes the starting and ending position of this segment on each transcript.

Table 1954 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1.

Segment cluster Z19204_node_17 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27 and Z19204_T42. Table 1955 below describes the-starting and ending position-of this-segment-on-each transcript.

Table 1955 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z192O4_P1 and Z19204_P15.

Segment cluster Z19204_node_49 according to the present invention is supported by 446 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1956 below describes the starting and ending position of this segment on each transcript. Table 1956 - Segment location on transcripts

This segment can be found in a non-coding region of transcriρt(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_50 according to the present invention is supported by 550 libraries. The number of libraries was determined as previously described. This segment can be found in the following tanscript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1957 below describes the starting and ending position of this segment on each transcript.

Table-l-957~ Segment-location-on-trarιscripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_Pl, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_58 according to the present invention is supported by 389 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1958 below describes the starting and ending position of this segment on each transcript.

Table 1958 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1 and Z19204_P13. This segment can also be found in the following protein(s): Z19204_P15, since it is in the coding region for the corresponding transcript.

Segment cluster Z 19204 node 63 according to the present invention is supported by 179 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204 J31, Z19204_T34 and Z19204_T42. Table 1959 below describes the starting and ending position of this segment on each transcript.

Table 1959 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1, Z19204_P13 and Z19204_P15. Segment cluster Z19204_node_64 according to the present invention is supported by 184 libraries. The number of libraries was determined as previously described. This segment can be found h the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1960 below describes the starting and ending position of this segment on each transcript.

Table 1960 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_65 according to the present invention is supported by 151 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1961 below describes the starting and ending position of this segment on each transcript.

Table 1961 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204__node_75 according to the present invention is supported by 169 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1962 below describes the starting and ending position of this segment on each transcript.

Table 1962 - Segment location on transcripts

JThis jegment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and : so are included in a separate description.

Segment cluster Z19204_node_18 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27 and Z19204_T42. Table 1963 below describes the starting and ending position of this segment on each transcript.

Table 1963 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z192O4_P1 and Z19204JP15.

Segment cluster Z19204_node_19 according to the present invention is supported by 637 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1964 below describes the starting and ending position of this segment on each transcript.

Table 1964 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_20 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T42. Table 1965 below describes the starting and ending position of this segment on each transcript.

Table 1965 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP15.

Segment cluster Z19204_node_21 according to the present invention can be found in the following transcript(s): Z19204_T42. Table 1966 below describes the starting and ending position of this segment on each transcript.

Table 1966 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z19204_P15.

Segment clusteFZ19204_node322 according to the present invention can beTound in the following transcript(s): Z19204_T42. Table 1967 below describes the starting and ending position of this segment on each transcript.

Table 1967 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15.

Segment cluster Z19204_node_23 according to the present invention is supported by 652 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Zl 9204JDO, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1968 below describes the starting and ending position of this segment on each transcript.

Table 1968 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204JP13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_25 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1969 below describes the starting and ending position of this segment on each transcript.

Table 1969 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript. Segment cluster Z19204jiode_26 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1970 below describes the starting and ending position of this segment on each transcript.

Table 1970 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z19204JP1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_27 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1971 below describes the starting and ending position of this segment on each transcript.

Table 1971 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_28 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1972 below describes the starting and ending position of this segment on each transcript.

Table 1972 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204JP13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_29 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1973 below describes the starting and ending position of this segment on each transcript.

Table 1973 - Segment location on ti'anscripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204JP13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_30 according to the present invention is supported by 406 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1974 below describes the starting and ending position of this segment on each transcript.

Table 1974 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of trans cript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_31 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1975 below describes the starting and ending position of this segment on each transcript. Table 1975 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_32 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204JB4 and Z19204_T42. Table 1976 below describes the starting and ending position of this segment on each transcript.

Table 1976 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP15. This segment can also be found in the following protein(s): Z19204_Pl and Z19204_P13, since it is in the coding region for the corresponding transcript. Segment cluster Z19204_node_34 according to the present invention is supported by 420 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204 J31, Z19204_T34 and Z19204_T42. Table 1977 below describes the starting and ending position of this segment on each transcript.

Table 1977 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP15. This segment can also be found in the following protein(s): Z19204_Pl_and Z19204JP13, since J.t is in the coding region for the corresponding transcript^ _

Segment cluster Z19204_node_35 according to the present invention is supported by 432 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31,

Z19204_T34 and Z19204_T42. Table 1978 below describes the starting and ending position of this segment on each transcript.

Table 1978 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_36 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1979 below describes the starting and ending position of this segment on each transcript.

Table 1979 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_40 according to the present invention is supported by 477 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1980 below describes the starting and ending position of this segment on each transcript.

Table 1980 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_48 according to the present invention is supported by 386 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1981 below describes the starting and ending position of this segment on each transcript.

Table 1981 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204_P15. This segment can also be found in the following protein(s): Z192O4_P1 and Z19204_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_51 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1982 below describes the starting and ending position of this segment on each transcript. Table 1982 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JU, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_52 according to the present invention is supported by 320 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1983 below describes the starting and ending position of this segment on each transcript.

-Table-198-3 - Segment location on transcripts-

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1, Z19204_P13 and Z19204J^>15.

Segment cluster Z19204_node_53 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1984 below describes the starting and ending position of this segment on each transcript. Table 1984 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_54 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1985 below describes the starting and ending position of this segment on each transcript.

Table 1985 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204__node_55 according to the present invention is supported by 314 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1986 below describes the starting and ending position of this segment on each transcript. Table 1986 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_56 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1987 below describes the starting and ending position of this segment on each transcript.

Table 1987 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1 and Z19204_P13. This segment can also be found in the following protein(s): Z19204_P15, since it is in the coding region for the corresponding transcript.

Segment cluster Z19204_node_57 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1988 below describes the starting and ending position of this segment on each transcript.

Table 1988 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1 and Z19204_P13. This segment can also be found in the following protein(s): Z19204JP15, since it is in the coding region for the corresponding transcript.

Segment_cluster Z19204_node_59 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1989 below describes the starting and ending position of this segment on each transcript. Table 1989 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15. Segment cluster Z19204_node_60 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1990 below describes the starting and ending position of this segment on each transcript.

Table 1990 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z192O4_P1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_61 according to the present invention is supported by 150 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204 T34 and Z19204_T42. Table 1991 below describes the starting and ending position of this segment on each transcript. Table 1991 - Segment location on transcripts

This segment can be found in a non-coding region of transcriρt(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15. Segment cluster Z 19204_node_62 according to the present invention is supported by 171 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1992 below describes the starting and ending position of this segment on each transcript.

Table 1992 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z192O4_P1, Z19204_P13 and Z19204_P15.

Segment _cluster Z19204_node_66 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1993 below describes the starting and ending position of this segment on each transcript.

Table 1993 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z192O4_P1, Z19204_P13 and Z19204_P15. Segment cluster Z19204_node_67 according to the present invention is supported by 238 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1994 below describes the starting and ending position of this segment on each transcript.

Table 1994 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204JP15.

Segment cluster Z19204_node_68 according to the present invention can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1995 below describes the starting and ending position of this segment on each transcript.

Table 1995 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z192O4_P1, Z19204_P13 and Z19204J^>15. Segment cluster Z19204_node_69 according to the present invention is supported by 228 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204 J31, Z19204_T34 and Z19204_T42. Table 1996 below describes the starting and ending position of this segment on each transcript.

Table 1996 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_70 according to the present invention is supported by 226 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1997 below describes the starting and ending position of this segment on each transcript.

Table 1997 - Segment location on transcripts

This segment can be found in a non-coding region of transcπpt(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15.

Segment cluster Z19204_node_73 according to the present invention is supported by 206 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204 J31, Z19204_T34 and Z19204_T42. Table 1998 below describes the starting and ending position of this segment on each transcript.

Table 1998 - Segment location on transcripts

This segment can be found in a non- coding regionjof transcripts] that are related to the following protein(s): Z19204JP1, Z19204JP13 and Z19204_P15.

Segment cluster Z19204_node_74 according to the present invention is supported by 193 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19204_T27, Z19204_T29, Z19204_T30, Z19204_T31, Z19204_T34 and Z19204_T42. Table 1999 below describes the starting and ending position of this segment on each transcript.

Table 1999 - Segment location on transcripts

I Z19204 T42 |I 3243 II 3283 I

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19204JP1, Z19204_P13 and Z19204_P15.

DESCRIPTION FOR CLUSTER Z24775

Cluster Z24775 features 5 transcript(s) and 26 segment(s) of interest, the names for which are given in Tables 2000 and 2001, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2002.

Table 2000 - Transcripts of interest

TranscriptName

Z24775 T23

Z24775 T26

Z24775 T27

Z24775 T28

Z24775 T29

Table2001 -Segmentsofinterest

SegmentNanw

Z24775 node 0

Z24775 node 1

Z24775 node 25

Z24775 node 31

Z24775 node 33

Z24775 node 37

Z24775 node 39

Z24775 node 47

Z24775 node 48

Z24775 node 51

Z24775 node 59

Z24775 node 8

Z24775 node 9

Z24775 node 13

Z24775 node 14

Z24775 node 16 Z24775 node 18

Z24775 node 20

Z24775 node 22

Z24775 node 24

Z24775 node 32

Z24775 node 41

Z24775 node 43

Z24775 node 52

Z24775 node 55

Z24775 node 57

Table 2002 - Proteins of interest

These sequences are variants of the known protein DNA mismatch repair protein MIh 1 (SwissProt accession identifier MLH1_HUMAN; known also according to the synonyms MutL protein homolog 1), referred to herein as the previously known protein. Protein DNΑ mismatch repair protein Mlh1 is known or believed to have the following function(s): Involved in the repair of mismatches in DNA. The sequence for protein DNA mismatch repair protein MM is given at the end of the application, as "DNA mismatch repair protein Mlhl amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2003.

Table 2003 - Amino acid mutations for Known Protein

Protein DNA mismatch repair protein Mlhl localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: mismatch repair, which are annotation(s) related to Biological Process; ATP binding, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster Z24775 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 52 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 52 and Table 2004. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: malignant tumors involving the lymph nodes.

52

Table 2004 - Normal tissue distribution

Table 2005 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z24775 features 26 segment(s), which were listed in Table 2001 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description oT each segment according to the present invention is ^"how provided.

Segment cluster Z24775_node_0 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2006 below describes the starting and ending position of this segment on each transcript.

Table 2006 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z24775_P17. Segment cluster Z24775_node_l according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2007 below describes the starting and ending position of this segment on each transcript.

Table 2007 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P17.

Segment cluster Z24775_node_25 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2008 below describes the starting and ending position of this segment on each transcript.

Table 2008 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P17.

Segment cluster Z24775_node_31 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23. Table 2009 below describes the starting and ending position of this segment on each transcript.

Table 2009 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z24775JP7. Segment cluster Z24775_node_33 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23. Table 2010 below describes the starting and ending position of this segment on each transcript.

Table 2010 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7.

Segment cluster Z24775_node_37 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23. Table 2011 below describes the starting and ending position of this segment on each transcript.

Table 2011 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7.

Segment cluster Z24775_node_39 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23. Table 2012 below describes the starting and ending position of this segment on each transcript.

Table 2012 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7. Segment cluster Z24775__node_47 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T26 and Z24775_T28. Table 2013 below describes the starting and ending position of this segment on each transcript.

Table 2013 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z24775_P15 and Z24775JP16.

Segment cluster Z24775_node_48 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23, Z24775_T26 and Z24775_T28. Table 2014 below-describes-the-starting-and ending-position of-this segment on-each transeript.

Table 2014 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7, Z24775_P15 and Z24775 P16.

Segment cluster Z24775_node_51 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T27. Table 2015 below describes the starting and ending position of this segment on each transcript.

Table 2015 - Segment location on transcripts 1232

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z24775_node_59 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23, Z24775_T26, Z24775_T27 and Z24775_T28. Table 2016 below describes the starting and ending position of this segment on each transcript.

Table 2016 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7, Z24775JP15 and

Z24775 P16.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z24775jnode_8 according to the present invention can be found in the following transcripts): Z24775_T29. Table 2017 below describes the starting and ending position of this segment on each transcript.

Table 2017 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775JP17.

Segment cluster Z24775_node_9 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2018 below describes the starting and ending position of this segment on each transcript.

Table 2018 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P17.

Segment cluster Z24775_node_13 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2019 below describes the starting and -ending-position-of-this-segment-on-each-transcript.

Table 2019 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775JP17.

Segment cluster Z24775_node_14 according to the present invention can be found in the following transcript(s): Z24775_T29. Table 2020 below describes the starting and ending position of this segment on each transcript.

Table 2020 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P17.

Segment cluster Z24775_node_16 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2021 below describes the starting and ending position of this segment on each transcript.

Table 2021 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P17.

Segment cluster Z24775_node_l 8 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2022 below describes the starting and ending position of this segment on each transcript. Table 2022 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P17.

Segment cluster Z24775_node_20 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2023 below describes the starting and ending position of this segment on each transcript.

Table 2023 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P17.

Segment cluster Z24775_node_22 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2024 below describes the starting and ending position of this segment on each transcript.

Table 2024 - Segment location on transcripts

0 This segment can be found in the following protein(s): Z24775_P17.

Segment cluster Z24775_node_24 according to the present invention is supported by 89 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T29. Table 2025 below describes the starting and -5- -ending-position of-this segment on-each transcript.

Table 2025 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P17.

0 Segment cluster Z24775_node_32 according to the present invention can be found in the following transcript(s): Z24775_T23. Table 2026 below describes the starting and ending position of this segment on each transcript.

Table 2026 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z24775_P7.

Segment cluster Z24775_node_41 according to the present invention is supported by 51 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z24775_T23. Table 2027 below describes the starting and ending position of this segment on each transcript.

Table 2027 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7.

Segment cluster Z24775_node_43 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23. Table 2028 below describes the starting and ending position oT this segment oϊFeach transcriptT^~

Table 2028 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7.

Segment cluster Z24775_node_52 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23, Z24775_T26 and Z24775_T27. Table 2029 below describes the starting and ending position of this segment on each transcript.

Table 2029 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7 and Z24775JP15.

Segment cluster Z24775_node_55 according to the present invention E supported by 135 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23, Z24775_T26, Z24775_T27 and Z24775_T28. Table 2030 below describes the starting and ending position of this segment on each transcript.

Table 2030 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775_P7, Z24775_P15 and

-Z24775-Pr6r-

Segment cluster Z24775_node_57 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24775_T23, Z24775_T26, Z24775_T27 and Z24775_T28. Table 2031 below describes the starting and ending position of this segment on each transcript.

Table 2031 - Segment location on transcripts

This segment can be found in the following protein(s): Z24775JP7, Z24775_P15 and Z24775 P16. DESCRIPTION FOR CLUSTER Z24779

Cluster Z24779 features 5 transcript(s) and 44 segment(s) of interest, the names for which are given in Tables 2032 and 2033, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2034.

Table 2032 - Transcripts of interest

TranscriptName

Z24779 T3

Z24779 T9

Z24779 TlO

Z24779 T13

Z24779 T17

Table2033-Segmentsofinterest

Z24779 node 59

Z24779 node 61

Z24779 node 75

Z24779 node 76

Z24779 node 78

Z24779 node 80

Z24779 node 86

Z24779 node 12

Z24779 node 14

Z24779 node 16

Z24779 node 25

Z24779 node 26

Z24779 node 30

Z24779 node 51

Z24779 node 55

Z24779 node 57

Z24779 node 63

Z24779 node 65

Z24779 node 67

Z24779 node 69

Z24779 node 71

Z24779 node 73

Z24779 node 79

Z247_79.jiødeL_8JL

Z24779 node 84

Table 2034 - Proteins of interest

These sequences are variants of the known protein Myomesin 1 (SwissProt accession identifier MYMl-HUMAN; known also according to the synonyms 190 kDa titin- associated protein; 190 kDa connectin- associated protein), referred to herein as the previously known protein.

Protein Myomesin 1 is known or believed to have the following function(s): Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. The sequence for protein Myomesin 1 is given at the end of the application, as "Myomesin 1 amino acid sequence".

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: striated muscle contraction; muscle development, which are annotation(s) related to Biological Process; structural protein of muscle, which are annotation(s) related to Molecular Function; and muscle thick filament, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nkn.nih.gov/projects/LocusLink/>.

The heart- selective diagnostic marker prediction engine provided the following results .with regard to_cluster-Z24-7-7SL_Eredictions were made for_selective-expression-of-transcripts of- this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 53 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 53, concerning the number of heart-specific clones in libraries/sequences; as well as with regard to the histogram in Figure 54, concerning the actual expression of oligonucleotides in various tissues, including heart.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non-heart ESTs, which was found to be 12.7; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific

ESTs which was found to be 2.9; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be l.lOE-17.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle -specific ESTs which was found to be 12.7, which clearly supports specific expression in heart tissue.

As noted above, cluster Z24779 features 44 segment(s), which were listed in Table 2033 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of -particular-interest-A-description-of-each. segment-according -to- the present -invention is now provided.

Segment cluster Z24779_node_0 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T10 and Z24779_T17. Table 2035 below describes the starting and ending position of this segment on each transcript.

Table 2035 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z24779_P4, Z24779_P10 and Z24779_P15. Segment cluster Z24779_node_2 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T10 and Z24779_T17. Table 2036 below describes the starting and ending position of this segment on each transcript.

Table 2036 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4, Z24779_P10 and Z24779_P15.

Segment cluster Z24779_node_4 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3₁_Z24779jri0^.d_Z24779_:r_T17. Table_2037_ below describes the starting and ending position of this segment on each transcript. Table 2037 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P10 and Z24779 P15.

Segment cluster Z24779_node_7 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T10 and Z24779_T17. Table 2038 below describes the starting and ending position of this segment on each transcript. Table 2038 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P10 and Z24779_P15.

Segment cluster Z24779_node_9 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T10 and Z24779_T17. Table 2039 below describes the starting and ending position of this segment on each transcript.

Table 2039 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P10 and Z24779 Pl 5.

Segment cluster Z24779_node_ 10 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T17. Table 2040 below describes the starting and ending position of this segment on each transcript.

Table 2040 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP15. Segment cluster Z24779_node_l 8 according to the present invention is supported by 12 libraπes. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2041 below describes the starting and ending position of this segment on each transcript.

Table 2041 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_20 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2042 below describes the starting and ending position of this segment on each transcript.

^"Table 2^~0^~42^~Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_22 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2043 below describes the starting and ending position of this segment on each transcript.

Table 2043 - Segment location on transcripts

Z24779 TlO 1678 1819

This segment can be found in the following protein(s): Z24779_P4 and Z24779JP10.

Segment cluster Z24779_node_27 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2044 below describes the starting and ending position of this segment on each transcript.

Table 2044 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_32 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2045 below describes the starting and ending position of this segment on each transcript.

Table 2045 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4 and Z24779_P10.

Segment cluster Z24779_node_34 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2046 below describes the starting and ending position of this segment on each transcript.

Table 2046 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779JP10.

Segment cluster Z24779_node_37 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2047 below describes the starting and ending position of this segment on each transcript.

Table 2047 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_39 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2048 below describes the starting and ending position of this segment on each transcript.

Table 2048 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_42 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2049 below describes the starting and ending position of this segment on each transcript.

Table 2049 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779JH0.

Segment cluster Z24779_node_46 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2050 below describes the starting and ending position of this segment on each transcript.

Table 2050 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_48 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T9. Table 2051 below describes the starting and ending position of this segment on each transcript.

Table 2051 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779J^D9. Segment cluster Z24779_node_49 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2052 below describes the starting and ending position of this segment on each transcript.

Table 2052 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and Z24779_P10.

Segment cluster Z24779_node_53 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2053 below describes the starting and ending position of this segment on each transcript.

Table 2053 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JM, Z24779_P9 and Z24779 PlO.

Segment cluster Z24779_node_59 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2054 below describes the starting and ending position of this segment on each transcript.

Table 2054 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and Z24779_P10.

Segment cluster Z24779_node_61 according to the present hvention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2055 below describes the starting and ending position of this segment on each transcript.

Table 2055 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and Z24779 PlO.

Segment cluster Z24779_node_75 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2056 below describes the starting and ending position of this segment on each transcript.

Table 2056 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4, Z24779_P9 and Z24779 PlO.

Segment cluster Z24779_node_76 according to the present invention is supported by 1 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): Z24779_T10. Table 2057 below describes the starting and ending position of this segment on each transcript.

Table 2057 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P10.

Segment cluster Z24779_node_78 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T13. Table 2058 below describes the starting and ^"ending position of lhls^~segment oh each transcript^"

Table 2058 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z24779_node_80 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T13. Table 2059 below describes the starting and ending position of this segment on each transcript.

Table 2059 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4.

Segment cluster Z24779_node_86 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T13. Table 2060 below describes the starting and ending position of this segment on each transcript.

Table 2060 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z24779_P4. This segment can also be found in the following protein(s): Z24779_P9, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z24779_node_12 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2061 below describes the starting and ending position of this segment on each transcript.

Table 2061 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_14 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2062 below describes the starting and ending position of this segment on each transcript.

Table 2062 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_16 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2063 below describes the starting and ending position of this segment on each transcript.

Table 2063 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_25 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2064 below describes the starting and ending position of this segment on each transcript.

Table 2064 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P10.

Segment cluster Z24779_node_26 according to the present invention can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2065 below describes the starting and ending position of this segment on each transcript. Table 2065 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4 and Z24779_P10.

Segment cluster Z24779_node_30 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3 and Z24779_T10. Table 2066 below describes the starting and ending position of this segment on each transcript.

Table 2066 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4 and Z24779_P10. Segment cluster Z24779_node_51 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2067 below describes the starting and ending position of this segment on each transcript.

Table 2067 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and Z24779_P10.

Segment cluster Z24779_node_55 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2068 below describes the starting and ending position of this segment on each transcript.

Table 2068 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and Z24779 PlO.

Segment cluster Z24779_node_57 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2069 below describes the starting and ending position of this segment on each transcript.

Table 2069 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and Z24779_P10.

Segment cluster Z24779_node_63 according to the present invention is supported by 23 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2070 below describes the starting and ending position of this segment on each transcript.

Table 2070 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4, Z24779_P9 and Z24779 PlO.

Segment cluster Z24779_node_65 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2071 below describes the starting and ending position of this segment on each transcript.

Table 2071 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4, Z24779_P9 and Z24779_P10.

Segment cluster Z24779_node_67 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2072 below describes the starting and ending position of this segment on each transcript.

Table 2072 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and

Z24779 PlO.

Segment cluster Z24779_node_69 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2073 below describes the starting and ending position of this segment on each transcript.

Table 2073 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779JP4, Z24779_P9 and Z24779 PlO.

Segment cluster Z24779_node_71 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2074 below describes the starting and ending position of this segment on each transcript.

Table 2074 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and Z24779 PlO.

Segment cluster Z24779_node_73 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T10. Table 2075 below describes the starting and ending position of this segment on each transcript.

Table 2075 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4, Z24779_P9 and Z24779 PlO.

Segment cluster Z24779_node_79 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T13. Table 2076 below describes the starting and ending position of this segment on each transcript.

Table 2076 - Segment location on transcripts

This segment can be found in the following protein(s): Z24779_P4 and Z24779_P9.

Segment cluster Z24779_node_81 according to the present invention can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T13. Table 2077 below describes the starting and ending position of this segment on each transcript.

Table 2077 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z24779_P4. This segment can also be found in the following protein(s):

Z24779_P9, since it is in the coding region for the corresponding transcript.

Segment cluster Z24779_node_84 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z24779_T3, Z24779_T9 and Z24779_T13. Table 2078 below describes the starting and ending position of this segment on each transcript.

Table 2078 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z24779_P4. This segment can also be found in the following protein(s): Z24779_P9, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER Z38489

Cluster Z38489 features 7 transcript(s) and 35 segment(s) of interest, the names for which are given in Tables 2079 and 2080, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2081.

Table 2079 - Transcripts of interest

TranscriptName

Z38489 T7

Z38489 T9

Z38489 TlO

Z38489 TIl

Z38489 T24

Z38489 T30

Z38489 T41

Table2080-Segmentsofinterest

SegmentName

Z38489 node 5

Z38489 node 7

Z38489 node 11

Z38489 node 26

Z38489 node 27

Z38489 node 54

Z38489 node 57

Z38489 node 60

Z38489 node 71

Z38489 node 74

Z38489 node 0

Z38489 node 1

Z38489 node 2

Z38489 node 3 Z38489 node 9

Z38489 node 16

Z38489 node 17

Z38489 node 18

Z38489 node 23

Z38489 node 28

Z38489 node 29

Z38489 node 37

Z38489 node 41

Z38489 node 44

Z38489 node 46

Z38489 node 49

Z38489 node 50

Z38489 node 59

Z38489 node 62

Z38489 node 63

Z38489 node 66

Z38489 node 69

Z38489 node 70

Z38489 node 72

Z38489 node 73

Table 2081 - Proteins of interest

These sequences are variants of the known protein Ubiquitin carboxyl- terminal hydrolase 10 (SwissProt accession identifier UB10_HUMAN; known also according to the synonyms EC 3.1.2.15; Ubiquitin thiolesterase 10; Ubiquitin- specific processing protease 10; Deubiquitinating enzyme 10), referred to herein as the previously known protein.

Protein Ubiquitin carboxyl- terminal hydrolase 10 is known or believed to have the following function(s): Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached. The sequence for protein Ubiquitin carboxyl- terminal hydrolase 10 is given at the end of the application, as "Ubiquitin carboxyl- terminal hydrolase 10 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2082. Table 2082 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: ubiquitin-dependent protein degradation, which are annotation(s) related to Biological Process; and cysteine-type endopeptidase; ubiquitin thiolesterase; hydrolase, which are annotation(s) related to Molecular Function.

The GO assignment relies on information fom one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslmk, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster Z38489 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 55 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 55 and Table 2083. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: colorectal cancer. 55

Table 2083 - Normal tissue distribution

Table 2084 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z38489 features 35 segment(s), which were listed in Table 2080 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z38489_node_5 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T10. Table 2085 below describes the starting and -ending position-of-this- segment-on each-transcript—

Table 2085 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P7.

Segment cluster Z38489_node_7 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7. Table 2086 below describes the starting and ending position of this segment on each transcript.

Table 2086 - Segment location on transcripts

Z38489 T7 139 268

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6.

Segment cluster Z38489_node_l l according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T9, Z38489_T11 and Z38489_T30. Table 2087 below describes the starting and ending position of this segment on each transcript.

Table 2087 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6 and Z38489_P12.

Segment cluster Z38489_node_26 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10 and Z38489_T11. Table 2088 below describes the starting and ending position of this segment on each transcript.

Table 2088 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6. This segment can also be found in the following protein(s): Z38489JP7, since it is in the coding region for the corresponding transcript.

Segment cluster Z38489_node_27 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10 and Z38489_T11. Table 2089 below describes the starting and ending position of this segment on each transcript.

Table 2089 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6 and Z38489_P7.

Segment cluster Z38489_node_54 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2090 below describes the starting and ending position of this segment on each transcript.

Table 2090 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7 and Z38489 P12. Segment cluster Z38489jnode_57 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T41. Table 2091 below describes the starting and ending position of this segment on each transcript.

Table 2091 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P23.

Segment cluster Z38489_node_60 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24, Z38489_T30 and Z38489_T41. Table 2092 below describes the starting and ending position of this segment on each transcript. Table 2092 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7, Z38489 P12 and Z38489 P23.

Segment cluster Z38489_node_71 according to the present invention is supported by 220 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24, Z38489_T30 and Z38489_T41. Table 2093 below describes the starting and ending position of this segment on each transcript.

Table 2093 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38489_P6, Z38489JP7, Z38489_P12 and Z38489_P23.

Segment cluster Z38489_node_74 according to the present invention is supported by 116 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11,

Z38489_T24, Z38489_T30 and Z38489_T41. Table 2094 below describes the starting aid ending position of this segment on each transcript.

Table 2094 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6, Z38489_P7, Z38489_P12 and Z38489_P23. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z38489_node_0 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2095 below describes the starting and ending position of this segment on each transcript.

Table 2095 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489JP6, Z38489_P7 and Z38489_P12.

Segment cluster Z38489_node_l according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2096 below describes the starting and ending position of this segment on each transcript. Table 2096 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489JP6, Z38489JP7 and Z38489_P12.

Segment cluster Z38489__node_2 according to the present invention can be found in the Mowing transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2097 below describes the starting and ending position of this segment on each transcript.

Table 2097 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6, Z38489JP7 and Z38489_P12.

Segment cluster Z38489_node_3 according to the present invention can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11 and Z38489_T30. Table 2098 below describes the starting and ending position of this segment on each transcript.

Table 2098 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489JP6, Z38489_P7 and Z38489_P12.

Segment cluster Z38489_node_9 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T11. Table 2099 below describes the starting and ending position of this segment on each transcript.

Table 2099 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38489_P6.

Segment cluster Z38489_node_16 according to the present invention can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11 and Z38489_T30. TableT2100 belowΕescribes the^~sTartirig^"arid ending position of ffiis^~segmerit^~δrT each transcripTT

Table 2100 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6 and Z38489JP12. This segment can also be found in the following protein(s): Z38489_P7, since it is in the coding region for the corresponding transcript. Segment cluster Z38489_node_17 according to the present invention can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11 and Z38489_T30. Table 2101 below describes the starting and ending position of this segment on each transcript.

Table 2101 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6 and Z38489JP12. This segment can also be found in the following protein(s): Z38489_P7, since it is in the coding region for the corresponding transcript.

-i Segment-cluster-Z38489-node— 1-8-aecording to-the-present-invention-is-supported-by -121- libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11 and Z38489_T30. Table 2102 below describes the starting and ending position of this segment on each transcript.

Table 2102 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6 and Z38489_P12. This segment can also be found in the following protein(s): Z38489JP7, since it is in the coding region for the corresponding transcript.

Segment cluster Z38489_node_23 according to the present invention is supported by 123 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10 and Z38489_T11. Table 2103 below describes the starting and ending position of this segment on each transcript.

Table 2103 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s)T^"Z38489jP6TThis segment can also be found ETthe^~lollowing^~protein(s): Z38489_P7, since it is in the coding region for the corresponding transcript.

Segment cluster Z38489_node_28 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10 and Z38489_T11. Table 2104 below describes the starting and ending position of this segment on each transcript.

Table 2104 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489JP6 and Z38489_P7. Segment cluster Z38489_node_29 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11 and Z38489_T24. Table 2105 below describes the starting and ending position of this segment on each transcript.

Table 2105 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489JP12. This segment can also be found in the following protein(s): -238489-P6-and-Z38489JP7, since-it-is-in-the-coding-regio n-for-the-corresponding -transcript —

Segment cluster Z38489_node_37 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11,

Z38489_T24 and Z38489_T30. Table 2106 below describes the starting and ending position of this segment on each transcript.

Table 2106 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P12. This segment can also be found in the following protein(s): Z38489_P6 and Z38489_P7, since it is in the coding region for the corresponding transcript.

Segment cluster Z38489_node_41 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2107 below describes the starting and ending position of this segment on each transcript.

Table 2107 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7 and Z38489 P12.

Segment cluster Z38489_node_44 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2108 below describes the starting and ending position of this segment on each transcript.

Table 2108 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7 and Z38489_P12.

Segment cluster Z38489_node_46 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2109 below describes the starting and ending position of this segment on each transcript.

Table 2109 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7 and Z38489 P12.

Segment cluster Z38489_node_49 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2110 below describes the starting and ending position of this segment on each transcript. Table 2110 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7 and Z38489_P12.

Segment cluster Z38489_node_50 according to the present invention can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24 and Z38489_T30. Table 2111 below describes the starting and ending position of this segment on each transcript.

Table 2111 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7 and

Z38489 P12.

Segment cluster Z38489_node_59 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11,

Z38489_T24, Z38489_T30 and Z38489_T41. Table 2112 below describes the starting and ending position of this segment on each transcript.

Table 2112 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489JP6, Z38489_P7, Z38489JP12 and Z38489_P23.

Segment cluster Z38489_node_62 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24, Z38489_T30 and Z38489_T41. Table 2113 below describes the starting and ending position of this segment on each transcript. Table 2113 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7, Z38489 P12 and Z38489 P23.

Segment cluster Z38489_node_63 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24, Z38489_T30 and Z38489_T41. Table 21 14 below describes the starting and ending position of this segment on each transcript.

Table 2114 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7,

Z38489 P12 and Z38489 P23.

Segment cluster Z38489__node_66 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489J9, Z38489_T10, Z38489_T11,

Z38489_T24, Z38489_T30 and Z38489_T41. Table 2115 below describes the starting and ending position of this segment on each transcript.

Table 2115 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7, Z38489 P12 and Z38489 P23. Segment cluster Z38489_node_69 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24, Z38489_T30 and Z38489_T41. Table 2116 below describes the starting and ending position of this segment on each transcript.

Table 2116 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489_P7, Z38489_P12 and Z38489_P23.

Segment cluster Z38489_node_70 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24, Z38489_T30 and Z38489_T41. Table 2117 below describes the starting and ending position of this segment on each transcript.

Table 2117 - Segment location on transcripts

This segment can be found in the following protein(s): Z38489_P6, Z38489JP7, Z38489 P12 and Z38489 P23.

Segment cluster Z38489_node_72 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24, Z38489_T30 and Z38489_T41. Table 2118 below describes the starting and ending position of this segment on each transcript.

Table 2118 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6, Z38489_P7, Z38489_P12 and Z38489_P23.

Segment cluster Z38489_node_73 according to the present invention can be found in the following transcript(s): Z38489_T7, Z38489_T9, Z38489_T10, Z38489_T11, Z38489_T24, Z38489_T30 and Z38489_T41. Table 2119 below describes the starting and ending position of this segment on each transcript.

Table 2119 - Segment location on transcripts

I Z38489 T41 I 1432 II 1448 I

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38489_P6, Z38489_P7, Z38489JP12 and Z38489_P23.

DESCRIPTION FOR CLUSTER Z39788

Cluster Z39788 features 17 transcript(s) and 32 segment(s) of interest, the names for which are given in Tables 2120 and 2121, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2122.

Table 2120 - Transcripts of interest

TranscriptName

Z39788 TO

Z39788 T2

Z39788 T3

Z39788 T4

Z39788 T6

Z39788 T7

Z39788 T8

Z39788 T9

Z39788 TIl

Z39788 T13

Z39788 T14

Z39788 T17

Z39788 T18

Z39788 T19

Z39788 T27

Z39788 T29

Z39788 T31

Table2121 -Segmentsofinterest

SegmentName

Z39788 node 0

Z39788 node 2

Z39788 node 4

Table 2122 - Proteins of interest

As noted above, cluster Z39788 features 32 segment(s), which were listed in Table 2121 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z39788_node_0 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T4, Z39788_T6, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T27, Z39788_T29 and Z39788_T31. Table 2123 below describes the starting and ending position of this segment on each transcript.

Table 2123 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P3. This segment can also be found in the following protein(s): Z39788JP1, Z39788_P6, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P24, Z39788_P26 and Z39788_P27, since it is in the coding region for the corresponding transcript.

Segment cluster Z39788_node_2 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T4, Z39788_T6, Z39788_T8, Z39788_T9, Z39788JN 1, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T27, Z39788_T29 and Z39788_T31. Table 2124 below describes the starting and ending position of this segment on each transcript.

Table 2124 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z39788_P3. This segment can also be found in the following protein(s): Z39788_P1, Z39788_P6, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P24, Z39788_P26 and Z39788_P27, since it is in the coding region for the corresponding transcript.

Segment cluster Z39788_node_4 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T31. Table 2125 below describes the starting and ending position of this segment on each transcript.

Table 2125 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788JP27.

Segment cluster Z39788_node_9 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T27. Table 2126 below describes the starting and ending position of this segment on each transcript.

Table 2126 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P24.

Segment cluster Z39788_node_l 1 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T29. Table 2127 below describes the starting and ending position of this segment on each transcript.

Table 2127 - Segment location on transcripts

Z39788 T29 671 831

This segment can be found in the following protein(s): Z39788_P26.

Segment cluster Z39788_node_13 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T2. Table 2128 below describes the starting and ending position of this segment on each transcript.

Table 2128 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P3.

Segment cluster Z39788_node_25 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T4, Z39788_T6, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14 and Z39788_T17. Table

2129 below describes the starting and ending position of this segment on each transcript.

Table 2129 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P1, Z39788JP3, Z39788_P6, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13 and Z39788_P16.

Segment cluster Z39788_node_27 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T3, Z39788_T7 and Z39788_T18. Table 2130 below describes the starting and ending position of this segment on each transcript.

Table 2130 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P4, Z39788_P7 and Z39788_P17.

Segment cluster Z39788jαode_28 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17 and Z39788_T18. Table 2131 below describes the starting and ending position of this segment on each transcript.

Table 2131 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788JP9, Z39788_P12, Z39788_P13, Z39788 P16 and Z39788 P17.

Segment cluster Z39788_node_42 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17 and Z39788_T18. Table 2132 below describes the starting and ending position of this segment on each transcript.

Table 2132 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788 P16 and Z39788 P17. Segment cluster Z39788_node_43 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T9, Z39788_T11 and Z39788_T17. Table 2133 below describes the starting and ending position of this segment on each transcript.

Table 2133 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P9 and Z39788_P16.

Segment cluster Z39788_node_46 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T11 and Z39788_T14. Table 2134 below describes the starting and ending position of this segment on each transcript.

Table 2134 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P9. This segment can also be found in the following protein(s): Z39788_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z39788_node_48 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T19. Table 2135 below describes the starting and ending position of this segment on each transcript.

Table 2135 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P18.

Segment cluster Z39788_node_49 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T18 and Z39788_T19. Table 2136 below describes the starting and ending position of this segment on each transcript.

Table 2136 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P17 and Z39788_P18. This segment can also be found in the following protein(s): Z39788_P1, Z39788_P3, Z39788_P4, Z39788_P6 and Z39788_P7, since it is in the coding region for the corresponding transcript. Segment cluster Z39788_node_54 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T18 and Z39788_T19. Table 2137 below describes the starting and ending position of this segment on each transcript.

Table 2137 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P17 and Z39788 Pl 8.

Segment cluster Z39788_node_56 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T4. Table 2138 below describes the starting and ending position of this segment on each transcript.

Table 2138 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P1.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z39788_node_l according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T4, Z39788_T6, Z39788_T8, Z39788 J9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T27, Z39788_T29 and Z39788_T31. Table 2139 below describes the starting and ending position of this segment on each transcript.

Table 2139 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P3. This segment can also be found in the following protein(s): Z39788_P1, Z39788_P6, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P24, Z39788_P26 and Z39788_P27, since it is in the coding region for the corresponding transcript.

Segment cluster Z39788_node_7 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788JTO, Z39788_T2, Z39788_T4, Z39788_T6, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T27 and Z39788_T29. Table 2140 below describes the starting and ending position of this segment on each transcript.

Table 2140 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P3. This segment can also be found in the following protein(s): Z39788JP1, Z39788_P6, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P24 and Z39788_P26, since it is in the coding region for the corresponding transcript. Segment cluster Z39788_node_8 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T4, Z39788_T6, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T27 and Z39788_T29. Table 2141 below describes the starting and ending position of this segment on each transcript.

Table 2141 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P3. This segment can also be found in the following protein(s):

Z39788_P1, Z39788_P6, Z39788_P8, Z39788J^>9, Z39788_P12, Z39788_P13, Z39788_P16,

Z39788_P24 and Z39788_P26, since it is in the coding region for the corresponding transcript.

Segment cluster Z39788_node_22 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T4, Z39788_T6, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14 and Z39788_T17. Table 2142 below describes the starting and ending position of this segment on each transcript. Table 2142 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788JP1, Z39788_P3, Z39788_P6, Z39788_P8, Z39788J^>9, Z39788_P12, Z39788_P13 and Z39788_P16.

Segment cluster Z39788_node_30 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17 and Z39788_T18. Table 2143 below describes the starting and ending position of this segment on each transcript.

Table 2143 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788JP1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788 P16 and Z39788 P17.

Segment cluster Z39788_node_31 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17 and Z39788_T18. Table 2144 below describes the starting and ending position of this segment on each transcript.

Table 2144 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788JP13, Z39788 P16 and Z39788 P17.

Segment cluster Z39788_node_32 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17 and Z39788_T18. Table 2145 below describes the starting and ending position of this segment on each transcript.

Table 2145 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 2146. Table 2146 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): Z39788JP1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16 and Z39788_P17.

Segment cluster Z39788_node_34 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T8, Z39788_T9, Z39788_T11 and Z39788_T14. Table 2147 below describes the starting and ending position of this segment on each transcript.

Table 2147 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788JP1, Z39788_P3,

Z39788 P4, Z39788_P8, Z39788 P9 and Z39788 P13.

Segment cluster Z39788_node_35 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found— in-the^~ following-transcript(s):-Z39788_TO,— Z39788iT2— Z39788iT3 — Z39788_T4,

Z39788_T8, Z39788_T9, Z39788_T11 and Z39788_T14. Table 2148 below describes the starting and ending position of this segment on each transcript.

Table 2148 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788JP1, Z39788_P3,

Z39788_P4, Z39788JP8, Z39788_P9 and Z39788_P13. Segment cluster Z39788_node_38 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9₅ Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17 and Z39788_T18. Table 2149 below describes the starting and ending position of this segment on each transcript.

Table 2149 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788JP1, Z39788_P3,

Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788 P16 and Z39788 P17.

Segment cluster Z39788_node_39 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788JTO, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17 and Z39788_T18. Table 2150 below describes the starting and ending position of this segment on each transcript. Table 2150 - Segment location on transcripts

This segment can be found in the following protein(s): Z39788_P1, Z39788JP3, Z39788_P4, Z39788_P6, Z39788JP7, Z39788_P8, Z39788_P9, Z39788JH2, Z39788_P13, Z39788 P16 and Z39788 P17.

Segment cluster Z39788_node_44 according to the present invention is supported by 9 KHrariesTThe number of found in the following transcript(s): Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T17 and Z39788_T18. Table 2151 below describes the starting and ending position of this segment on each transcript.

Table 2151 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 2152.

Table 2152 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788_P9 and Z39788JP16. This segment can also be found in the following protein(s): Z39788_P8, Z39788_P12 and Z39788JP17, since it is in the coding region for the corresponding transcript.

Segment cluster Z39788_node_50 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788JT18 and Z39788_T19. Table 2153 below describes the starting and ending position of this segment on each transcript.

Table 2153 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788JP1, Z39788_P3, Z39788_P4, Z39788 J^»6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P17 and Z39788 P18.

Segment cluster Z39788_node_51 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T18 and Z39788_T19. Table 2154 below describes the starting and ending position of this segment on each transcript.

Table 2154 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788JP1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P17 and Z39788 P18. Segment cluster Z39788_node_52 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6, Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17, Z39788_T18 and Z39788_T19. Table 2155 below describes the starting and ending position of this segment on each transcript.

Table 2155 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z39788JP1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788_P8, Z39788_P9, Z39788_P12, Z39788JP13, Z39788_P16, Z39788_P17 and Z39788 P18.

Segment cluster Z39788_node_53 according to the present invention can be found in the following transcript(s): Z39788_T0, Z39788_T2, Z39788_T3, Z39788_T4, Z39788_T6,

Z39788_T7, Z39788_T8, Z39788_T9, Z39788_T11, Z39788_T13, Z39788_T14, Z39788_T17,

Z39788_T18 and Z39788_T19. Table 2156 below describes the starting and ending position of this segment on each transcript.

Table 2156 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39788JP1, Z39788_P3, Z39788_P4, Z39788_P6, Z39788_P7, Z39788J^»8, Z39788_P9, Z39788_P12, Z39788_P13, Z39788_P16, Z39788_P17 and Z39788 P18.

DESCRIPTION FOR CLUSTER Z40569

Cluster Z40569 features 5 transcript(s) and 14 segment(s) of interest, the names for which are given in Tables 2157 and 2158, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2159.

Table 2157 - Transcripts of interest

Transcript Name

Z40569 Tl

Z40569 T2

Z40569 T5

Z40569 T7

Z40569 T8 Table2158-Segmentsofinterest

SegmentNaπw

Z40569 node 0

Z40569 node 3

Z40569 node 5

Z40569 node 10

Z40569 node 12

Z40569 node 13

Z40569 node 14

Z40569 node 15

Z40569 node _16

Z40569 node 18

Z40569 node 19

Z40569 node 20

Z40569 node 7

Z40569 node 9

Table 2159 - Proteins of interest

These sequences are variants of the known protein DNA replication complex GINS protein PSF2 (SwissProt accession identifier PSF2JHUMAN; known also according to the synonyms HSPC037; CGI- 122; DC5), referred to herein as the previously known protein.

Protein DNA replication complex GINS protein PSF2 is known or believed to have the following function(s): The GINS complex seems to play an essential role in the initiation of DNA replication (By similarity). The sequence for protein DNA replication complex GINS protein PSF2 is given at the end of the application, as "DNA replication complex GINS protein PSF2 amino acid sequence". Protein DNA replication complex GINS protein PSF2 localization is believed to be Nuclear (By similarity). The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: DNA replication, which are annotation(s) related to Biological Process; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster Z40569 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 56 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 56 and Table 2160. This cluster is overexpressed (at least at a minimum level) in the _following_pathological-xonditions:--brain_malignant_tamors_^epithelial_malignant-tumors-and a- mixture of malignant tumors from different tissues. 56 Table 2160 - Normal tissue distribution

Table 2161 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z40569 features 14 segment(s), which were listed in Table 2158 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster Z40569_node_0 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40569_T8. Table 2162 below describes the starting and ending position of this segment on each transcript.

Table 2162 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40569_P3.

Segment cluster Z40569_node_3 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40569_T1, Z40569_T2 and Z40569_T5. Table 2163 below describes the starting and ending position of this segment on each transcript.

Table 2163 - Segment location on transcripts

This segment can be found in the following protein(s): Z4O569_P1 and Z40569_P2.

Segment cluster Z40569_node_5 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40569_T7. Table 2164 below describes the starting and ending position of this segment on each transcript.

Table 2164 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40569JP3.

Segment cluster Z40569_node_10 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40569_T5. Table 2165 below describes the starting and ending position of this segment on each transcript.

Table 2165 - Segment location on transcripts

0

This segment can be found in the following protein(s): Z40569_P2.

Segment cluster Z40569_node_12 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be -5. found-in-the- following- transcript(s);-Z40569_;=T5_^-T-able-2-l 66-below-describes -the-starting_and— ending position of this segment on each transcript.

Table 2166 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the 0 following protein(s): Z40569_P2.

Segment cluster Z40569_node_13 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O569_T1, Z40569_T2, Z40569_T5, Z40569_T7 and 5 Z40569_T8. Table 2167 below describes the starting and ending position of this segment on each transcript. Table 2167 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40569_P2. This segment can also be found in the following protein(s): Z4O569_P1 and Z40569_P3, since it is in the coding region for the corresponding transcript.

Segment cluster Z40569_node_14 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40569_T5. Table 2168 below describes the starting and ending position of this segment on each transcript.

Table 2168 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40569_P2.

Segment cluster Z40569_node_15 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40569_T1, Z40569_T2, Z40569_T5, Z40569_T7 and Z40569_T8. Table 2169 below describes the starting and ending position of this segment on each transcript.

Table 2169 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40569JP2. This segment can also be found in the following protein(s): Z4O569_P1 and Z40569_P3, since it is in the coding region for the corresponding transcript.

Segment cluster Z40569_node_16 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O569_T1, Z40569_T2, Z40569_T5, Z40569_T7 and Z40569_T8. Table 2170 below describes the starting and ending position of this segment on each transcript.

-Table 2170 -Segment location-on-transcripts-

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z4O569_P1, Z40569_P2 and Z40569_P3.

Segment cluster Z40569_node_18 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O569_T1, Z40569_T2, Z40569_T5, Z40569_T7 and Z40569_T8. Table 2171 below describes the starting and ending position of this segment on each transcript. Table 2171 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z4O569_P1, Z40569_P2 and Z40569_P3.

Segment cluster Z40569_node_19 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O569_T1, Z40569_T5, Z40569_T7 and Z40569_T8. Table 2172 below describes the starting and ending position of this segment on each transcript.

Table 2172 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40569JP1, Z40569_P2 and Z40569_P3.

Segment cluster Z40569_node_20 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40569_T1, Z40569_T2, Z40569_T5, Z40569_T7 and Z40569_T8. Table 2173 below describes the starting and ending position of this segment on each transcript. Table 2173 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z40569JP1, Z40569_P2 and Z40569_P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z40569jnode_7 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40569 Tl , Z40569 T2, Z40569 T5, Z40569 T7 and Z40569_T8. Table 2174 below describes the starting and ending position of this segment on each transcript.

Table 2174 - Segment location on transcripts

This segment can be found in the following protein(s): Z4O569_P1, Z40569_P2 and Z40569 P3.

Segment cluster Z40569_node_9 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O569_T1, Z40569_T2, Z40569_T5, Z40569_T7 and Z40569_T8. Table 2175 below describes the starting and ending position of this segment on each transcript.

Table 2175 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 2176.

Table 2176 - Oligonucleotides related to this segment

Oligonucleotide name Overexpressed in cancers Chip reference

R09987 0 7 0 lung malignant tumors LUN

This segment can be found in the following protein(s): Z40569JP1, Z40569_P2 and Z40569 P3.

DESCRIPTION FOR CLUSTER Z44103

Cluster Z44103 features 8 transcript(s) and 31 segment(s) of interest, the names for which are given in Tables 2177 and 2178, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2179.

Table 2177 - Transcripts of interest

Transcript Name

Z44103 T3 Z44103 T7

Z44103 T9

Z44103 TlO

Z44103 T16

Z44103 T20

Z44103 T21

Z44103 T29

Table 2178 - Segments of interest

SegmentName

Z44103 node 0

Z44103 node 3

Z44103 node 11

Z44103 node 14

Z44103 node 30

Z44103 node 33

Z44103 node 35

Z44103 node 1

Z44103 node 2

Z44103 node 4

Z44103 node 8

Z44103 node 9

-Z44-1-Θ3~node-I0-

Z44103 node 12

Z44103 node 13

Z44103 node 15

Z44103 node 16

Z44103 node 17

Z44103 node 18

Z44103 node 19

Z44103 node 20

Z44103 node 21

Z44103 node 22

Z44103 node 23

Z44103 node 25

Z44103 node 26

Z44103 node 27

Z44103 node 28

Z44103 node 29

Z44103 node 32

Z44103 node 34 Table 2179 - Proteins of interest

Cluster Z44103 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 57 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure— §7-and-T-able-21-80-This- cluster— is-overexpressed-(at-least^t-a-minimum-level) -in the- following pathological conditions: lung malignant tumors.

57 Table 2180 - Normal tissue distribution

Table 2181 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z44103 features 31 segment(s), which were listed in Table 2178 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z44103_node_0 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2182 below describes the starting and ending position of this segment on each transcript.

Table 2182 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103JP1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103_P9 and Z44103 P16.

Segment cluster Z44103_node_3 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T9, Z44103_T10, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2183 below describes the starting and ending position of this segment on each transcript. Table 2183 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 2184.

Table 2184 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103_P4, Z44103_P5, Z44103_P9 and Z44103_P16. This segment can also be found in the following protein(s): Z441O3_P1, since it is in the coding region for the corresponding transcript.

Segment cluster Z44103_node_l l according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T7, Z44103_T10 and Z44103_T16. Table 2185 below describes the starting and ending position of this segment on each transcript.

Table 2185 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103_P6. This segment can also be found in the following protein(s): Z44103JP5, since it is in the coding region for the corresponding transcript.

Segment cluster Z44103_node_14 according to the present invention is supported by 183 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2186 below describes the starting and ending position of this segment on each transcript.

Table 2186 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103JP5, Z44103_P4, Z44103JP6, Z44103_P9 and Z44103_P16.

Segment cluster Z44103_node_30 according to the present invention is supported by 184 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10,

Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2187 below describes the starting and ending position of this segment on each transcript.

Table 2187 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103 P9 and Z44103_P16.

Segment cluster Z44103_node_33 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T21 and Z44103_T29. Table 2188 below describes the starting and ending position of this segment on each transcript.

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z441O3_P1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16.

Segment cluster Z44103_node_35 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T21 and Z44103_T29. Table 2189 below describes the starting and ending position of this segment on each transcript.

Table 2189 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z441O3_P1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103_P9 and Z44103 P16.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segmeπt^~cluster Z44103^node^~l^~according to the present inventron^~ can^~be^~fbundτn^~the- following transcript(s): Z44103_T3, Z44103_T9, Z44103_T10, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2190 below describes the starting and ending position of this segment on each transcript.

Table 2190 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103JP1, Z44103JP4, Z44103_P5, Z44103_P9 and Z44103_P16. Segment cluster Z44103_node_2 according to the present invention can be found in the following transcript(s): Z44103_T3, Z44103_T9, Z44103_T10, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2191 below describes the starting and ending position of this segment on each transcript.

Table 2191 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z441O3_P1, Z44103_P4, Z44103_P5, Z44103_P9 and Z44103_P16.

Segment cluster Z44103_node_4 according to the present invention is supported by 169 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2192 below describes the starting and ending position of this segment on each transcript. Table 2192 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103_P5, Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16. This segment can also be found in the following protein(s): Z44103JP1, since it is in the coding region for the corresponding transcript.

Segment cluster Z44103_node_8 according to the present invention is supported by 169 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2193 below describes the starting and ending position of this segment on each transcript.

Table 2193 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103_P5, Z44103_P6, Z44103_P9 and Z44103_P16. This segment can also be found in the following protein(s): Z441O3_P1 and Z44103_P4, since it is in the coding region for the corresponding transcript.

Segment cluster Z44103_node_9 according to the present invention can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2194 below describes the starting and ending position of this segment on each transcript.

Table 2194 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103_P5, Z44103_P6, Z44103_P9 and Z44103_P16. This segment can

5 also be found in the following protein(s): Z441O3_P1 and Z44103_P4, since it is in the coding region for the corresponding transcript.

Segment cluster Z44103_node_ 10 according to the present invention can be found in the following transcript(s): Z44103_T7, Z44103_T9, Z44103JN0 and Z44103_T16. Table 2195 _lP___belQW_deseribes the starting and ending position of this segment on each transcript.

Table 2195 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the

15 following protein(s): Z44103_P5 and Z44103_P6. This segment can also be found in the following protein(s): Z44103_P4, since it is in the coding region for the corresponding transcript. Segment cluster Z44103_node_12 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2196 below describes the starting and ending position of this segment on each transcript.

Table 2196 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the -10- — followiπg-protein(s)rZ44103-P6^~Z44103-P9-and Z44-103 -P 16-This-segment-can-also^~be-found- in the following protein(s): Z441O3_P1, Z44103_P5 and Z44103_P4, since it is in the coding region for the corresponding transcript.

Segment cluster Z44103_node_13 according to the present invention is supported by 5

15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T16. Table 2197 below describes the starting and ending position of this segment on each transcript.

Table 2197 - Segment location on transcripts

20 This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z44103_P6. Segment cluster Z44103_node_15 according to the present invention can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2198 below describes the starting and ending position of this segment on each transcript.

Table 2198 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16.

Segment cluster Z44103_node_16 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T21. Table 2199 below describes the starting and ending position of this segment on each transcript.

Table 2199 - Segment location on transcripts

This segment can be found in the following protein(s): Z44103_P9.

Segment cluster Z44103_node_17 according to the present invention is supported by 181 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20 and Z44103_T21. Table 2200 below describes the starting and ending position of this segment on each transcript.

Table 2200 - Segment location on transcripts

This segment can be found in the following protein(s): Z44103JP1, Z44103JP5,

Z44103_P4, Z44103_P6 and Z44103_P9.

Segment cluster Z44103_node_18 according to the present invention can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20 and Z44103_T21. Table 2201 below describes the starting and ending position of this segment on each transcript.

Table 2201 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5, Z44103_P4, Z44103_P6 and Z44103_P9.

Segment cluster Z44103_node_19 according to the present invention is supported by 178 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20 and Z44103_T21. Table 2202 below describes the starting and ending position of this segment on each transcript.

Table 2202 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5, Z44103_P4, Z44103_P6 and Z44103_P9.

Segment cluster Z44103_node_20 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be fcund in the following transcript(s): Z44103_T21. Table 2203 below describes the starting and ending position of this segment on each transcript.

Table 2203 - Segment location on transcripts

This segment can be found in the following protein(s): Z44103_P9.

Segment cluster Z44103_node_21 according to the present invention can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2204 below describes the starting and ending position of this segment on each transcript.

Table 2204 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16.

Segment cluster Z44103_node_22 according to the present invention is supported by 174 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2205 below describes the starting and ending position of this segment on each transcript. Tnble^205^-egtne}rtiOvatiσπτm^~tmnscripts^{~~ ~}

This segment can be found in the following protein(s): Z441O3_P1, Z44103JP5, Z44103_P4, Z44103 J^>6, Z44103_P9 and Z44103_P16.

Segment cluster Z44103_node_23 according to the present invention is supported by 165 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2206 below describes the starting and ending position of this segment on each transcript.

Table 2206 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5,

Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16.

Segment cluster Z44103_node_25 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found- in-^h«-followinB-transcript(s):-Z44103iT3— Z44103_T7,-Z441033T9— Z44103-T10,-

Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2207 below describes the starting and ending position of this segment on each transcript.

Table 2207 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5,

Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16. Segment cluster Z44103_node_26 according to the present invention can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2208 below describes the starting and ending position of this segment on each transcript.

Table 2208 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5,

Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16. , _ — , — _ _ _ . _ , _ . __ __ _

Segment cluster Z44103_node_27 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T21. Table 2209 below describes the starting and ending position of this segment on each transcript. Table 2209 - Segment location on transcripts

This segment can be found in the following protein(s): Z44103_P9.

Segment cluster Z44103_node_28 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T20, Z44103_T21 and Z44103_T29. Table 2210 below describes the starting and ending position of this segment on each transcript.

Table 2210 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5,

Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16.

Segment cluster Z44103_node_29 according to the present invention can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z441θ33F20rZ44t03^T21-and -Z441033T29r-Table-221-l-below-describes-trre-starting ^~and- ending position of this segment on each transcript.

Table 2211 - Segment location on transcripts

This segment can be found in the following protein(s): Z441O3_P1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103_P9 and Z44103_P16. Segment cluster Z44103_node_32 according to the present invention can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10, Z44103_T16, Z44103_T21 and Z44103_T29. Table 2212 below describes the starting and ending position of this segment on each transcript. Table 2212 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103JP1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103_P9 and Z44103 P16.

Segment cluster Z44103_node_34 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44103_T3, Z44103_T7, Z44103_T9, Z44103_T10,

Z44103_T16, Z44103_T21 and Z44103_T29. Table 2213 below describes the starting and ending position of this segment on each transcript.

Table 2213 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44103JP1, Z44103_P5, Z44103_P4, Z44103_P6, Z44103J^>9 and Z44103_P16.

DESCRIPTION FOR CLUSTER AA056634

Cluster AA056634 features 8 transcript(s) and 17 segment(s) of interest, the names for which are given in Tables 2214 and 2215, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2216.

Table 2214 - Transcripts of interest

Transcrlpt'Name

AA056634 Tl

AA056634 T2

AA056634 T3

AA056634 T4

AA056634 T5

AA056634 T9

AA056634 T14

-AA056634-T15 - -

Table 2215 - Segments of interest

Segment Name

AA056634 node 0

AA056634 node 3

AA056634 node 5

AA056634 node 12

AA056634 node 14

AA056634 node 16

AA056634 node 20

AA056634 node 21

AA056634 node 22

AA056634 node 23

AA056634 node 24

AA056634 node 1

AA056634 node 6

AA056634 node 7

AA056634 node 11 AA056634 node 18

AA056634 node 19

Table 2216 - Proteins of interest

These sequences are variants of the known protein Pituitary homeobox 1 (SwissProt accession identifier PIX1_HUMAN; known also according to the synonyms Hindlimb expressed homeobox protein backfoot), referred to herein as the previously known protein.

Protein Pituitary homeobox 1 is known or believed to have the following function(s): May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. The sequence for protein Pituitary homeobox 1 is given at the end of the application, as "Pituitary homeobox 1 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2217.

-Table-2217--~Amino-aeid-mutationsfor-Known-Protein — - — — — — — —

Protein Pituitary homeobox 1 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: skeletal development; transcription regulation; morphogenesis, which are annotation(s) related to Biological Process; transcription factor, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular

Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster AA056634 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 58 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 58 and Table 2218. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues and pancreas carcinoma.

Table 2219 ~ P values and ratios for expression in cancerous tissue

As noted above, cluster AA056634 features 17 segment(s), which were listed in Table 2215 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster AA056634_node_0 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA056634_T4, AA056634_T5, AA056634_T14 and

AA056634_T15. Table 2220 below describes the starting and ending position of this segment on each transcript.

Table 2220 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AAO56634_P1 and AA056634_P5.

Segment cluster AA056634_node_3 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA056634_T14 and AA056634_T15. Table 2221 below describes the starting and ending position of this segment on each transcript.

Table 2221 - Segment location on transcripts

This segment can be found in the following protein(s): AA056634 P5.

Segment cluster AA056634_node_5 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AAO56634_T1, AA056634_T2 and AA056634_T3. Table 2222 below describes the starting and ending position of this segment on each transcript.

Table 2222 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA056634_P6. Segment cluster AA056634_node_12 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA056634_T1, AA056634_T2, AA056634_T3, AA056634_T4 and AA056634_T5. Table 2223 below describes the starting and ending position of this segment on each transcript.

Table 2223 - Segment location on transcripts

This segment can be found in the following protein(s): AA056634_P6 and AA056634JP1.

Segment cluster AA056634_node_14 according to the present invention is supported by 4 libraries. -The-number-of-libraries-was-determined-as-previously described.-This segment-can be- found in the following transcript(s): AA056634_T9. Table 2224 below describes the starting and ending position of this segment on each transcript. Table 2224 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AA056634_P2.

Segment cluster AA056634_node_16 according to the present invention is supported by

43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AAO56634_T1, AA056634_T2, AA056634_T3, AA056634_T4, AA056634_T5 and AA056634_T9. Table 2225 below describes the starting and ending position of this segment on each transcript.

Table 2225 - Segment location on transcripts

This segment can be found in the following protein(s): AA056634_P6, AA056634_Pl and AA056634 P2.

Segment cluster AA056634_node_20 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AAO56634_T1, AA056634_T2, AA056634_T3, AA056634_T4, AA056634_T5 and AA056634 T9. Table 2226 below describes the starting and ending position of this segment on each transcript.

Table 2226 - Segment location on transcripts

This segment can be found in the following protein(s): AA056634_P6, AAO56634_P1 and AA056634 P2.

Segment cluster AA056634_node_21 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA056634_T1, AA056634_T2, AA056634_T3, AA056634_T4, AA056634_T5 and AA056634_T9. Table 2227 below describes the starting and ending position of this segment on each transcript.

Table 2227 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA056634_P6, AAO56634_P1 and AA056634_P2.

Segment cluster AA056634_node_22 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA056634_. T1, AA056634 T2, AA056634__T3,

AA056634_T4, AA056634_T5 and AA056634_T9. Table 2228 below describes the starting and ending position of this segment on each transcript.

Table 2228 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA056634_P6, AAO56634_P1 and AA056634_P2. Segment cluster AA056634_node_23 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AAO56634_T1, AA056634_T2, AA056634_T3, AA056634_T4, AA056634_T5 and AA056634_T9. Table 2229 below describes the starting and ending position of this segment on each transcript.

Table 2229 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA056634_P6, AAO56634_P1 and AA056634_P2.

Segment cluster AA056634_node 24 according to the present invention is supported by

36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA056634_T1, AA056634_T2, AA056634_T3,

AA056634_T4, AA056634_T5 and AA056634_T9. Table 2230 below describes the starting and ending position of this segment on each transcript.

Table 2230 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AA056634_P6, AAO56634_P1 and AA056634_P2. 2005/002438

1334

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster AA056634_node_l according to the present invention can be found in the following transcript(s): AA056634_T5 and AA056634_T15. Table 2231 below describes the starting and ending position of this segment on each transcript. Table 2231 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AAO56634_P1 and AA056634JP5.

Segment cluster AA056634_node_6 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AAO56634_T1 and AA056634_T2. Table 2232 below describes the starting and ending position of this segment on each transcript.

Table 2232 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AA056634_P6.

Segment cluster AA056634_node_7 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA056634_T2. Table 2233 below describes the starting and ending position of this segment on each transcript.

Table 2233 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster AA056634_node_l 1 according to the present invention is supported by

22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA056634_T1, AA056634_T2, AA056634_T3, AA056634_T4 and AA056634_T5. Table 2234 below describes the starting and ending position of this segment on each transcript.

Table 2234 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA056634_P6 and AAO56634_P1.

Segment cluster AA056634_node_18 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AAO56634 _T1, AA056634_T2, AA056634_T3, AA056634_T4, AA056634_T5 and AA056634_T9. Table 2235 below describes the starting and ending position of this segment on each transcript.

Table 2235 - Segment location on transcripts

This segment can be found in the following protein(s): AA056634_P6, AAO56634_P1 and AA056634_P2.

Segment cluster AA056634_node_19 according to the present invention can be found in the following transcript(s): AAO56634_T1, AA056634_T2, AA056634_T3, AA056634_T4, AA056634_T5 and AA056634_T9. Table 2236 below describes the starting and ending position of this segment on each transcript.

Table 2236 - Segment location on transcripts

This segment can be found in the following protein(s): AA056634_P6, AAO56634_P1 and AA056634 P2.

DESCRIPTION FOR CLUSTER AA318609

Cluster AA318609 features 3 transcript(s) and 37 segment(s) of interest, the names for which are given in Tables 2237 and 2238, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2239. Table 2237 - Transcripts of interest

Transcript Name

AA318609 T5

AA318609 T9

AA318609 T23

Table 2238 - Segments of interest

Segment Name

AA318609 node 7

AA318609 node 10

AA318609 node 17

AA318609 node 37

AA318609 node 49

AA318609 node 60

AA318609 node 62

AA318609 node 65

AA318609 node 73

AA318609 node 0

AA318609 node 5

AA318609 node 6

AA318609 node 8

AA318609^" node 9

AA318609 node 11

AA318609 node 13

AA318609 node 15

AA318609 node 19

AA318609 node 20

AA318609 node 22

AA318609 node 24

AA318609 node 26

AA318609 node 28

AA318609 node 31

AA318609 node 33

AA318609 node 35

AA318609 node 38

AA318609 node 39

AA318609 node 40

AA318609 node 42

AA318609 node 47

AA318609 node 53

AA318609 node 56 T/IB2005/002438

1338

AA318609 node 58

AA318609 node 67

AA318609 node 69

AA318609 node 70

Table 2239 - Proteins of interest

Cluster AA318609 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 59 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 59 and Table 2240. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors. 59

Table 2240 - Normal tissue distribution

Table 2241 - P values and ratios for expression in cancerous tissue

As noted above, cluster AA318609 features 37 segment(s), which were listed in Table

2238 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster AA318609_node_7 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5. Table 2242 below describes the starting and ending position of this segment on each transcript.

Table 2242 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P 1.

Segment cluster AA318609_node_10 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5. Table 2243 below describes the starting and ending position of this segment on each transcript.

Table 2243 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_Pl .

Segment cluster AA318609_node_17 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2244 below describes the starting and ending position of this segment on each transcript.

Table 2244 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609JP3. This segment can also be found in the following protein(s): AA3186O9__P1 and AA318609JP11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609__node_37 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2245 below describes the starting and ending position of this segment on each transcript.

Table 2245 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA3186O9_P11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_49 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2246 below describes the starting and ending position of this segment on each transcript.

Table 2246 - Segment location on transcripts

002438

1342

This segment can be found in the following protein(s): AA3186O9_P1 and AA318609_P3.

Segment cluster AA318609_node_60 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2247 below describes the starting and ending position of this segment on each transcript.

Table 2247 - Segment location on transcripts

This segment can be found in the following protein(s): AA318609JP1 and

AA318609 P3.

Segment cluster AA318609_node_62 according to the present invention is supported by -35 libraries. JEhe-number-of libraries-was-determined-as previously-described. This segment can- be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2248 below describes the starting and ending position of this segment on each transcript.

Table 2248 - Segment location on transcripts

This segment can be found in the following protein(s): AA3186O9_P1 and AA318609 P3.

Segment cluster AA318609_node_65 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2249 below describes the starting and ending position of this segment on each transcript. Table 2249 - Segment location on transcripts

This segment can be found in the following protein(s): AA3186O9_P1 and AA318609_P3.

Segment cluster AA318609_node_73 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2250 below describes the starting and ending position of this segment on each transcript.

Table 2250 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_Pl l. This segment can also be found in the following protein(s): AA318609JP1 and AA318609JP3, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster AA318609_node_0 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2251 below describes the starting and ending position of this segment on each transcript.

Table 2251 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P 1 , AA318609_P3 and AA318609_P 11.

Segment cluster AA318609_node_5 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2252 below describes the starting and ending position of this segment on each transcript.

Table 2252 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA3186O9_P1, AA318609_P3 and AA3186O9_P11.

Segment cluster AA318609_node_6 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5. Table 2253 below describes the starting and ending position of this segment on each transcript.

Table 2253 - Segment location on transcripts

AA318609 T5 143 247

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA3186O9_P1.

Segment cluster AA318609_node_8 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2254 below describes the starting and ending position of this segment on each transcript.

Table 2254 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609JP1, AA318609_P3 and AA318609JP11.

Segment cluster AA318609_node_9 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5. Table 2255 below describes the starting and ending position of this segment on each transcript.

Table 2255 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_Pl.

Segment cluster AA318609_node_ll according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2256 below describes the starting and ending position of this segment on each transcript.

Table 2256 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA318609_Pl and AA3186O9_P11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_13 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609JT23. Table 2257 below describes the starting and ending position of this segment on each transcript.

Table 2257 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA318609_Pl and AA3186O9_P11, since it is in the coding region for the corresponding transcript. Segment cluster AA318609_node_15 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2258 below describes the starting and ending position of this segment on each transcript.

Table 2258 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA3186O9_P11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_19 according to the present invention is supported by

22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2259 below describes the starting and ending position of this segment on each transcript.

Table 2259 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA3186O9_P11, since it is in the coding region for the corresponding transcript. Segment cluster AA318609_node_20 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2260 below describes the starting and ending position of this segment on each transcript.

Table 2260 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA318609_Pl l, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_22 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2261 below describes the starting and ending position of this segment on each transcript.

Table 2261 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA318609_Pl l, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_24 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2262 bebw describes the starting and ending position of this segment on each transcript.

Table 2262 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA318609_Pll, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_26 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2263 below describes the starting and ending position of this segment on each transcript.

Table 2263 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the 05 002438

1350 following protein(s): AA318609_P3. This segment can also be found in the following protem(s): AA318609 JPl and AA3186O9_P11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_nodeJ28 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2264 below describes the starting and ending position of this segment on each transcript.

Table 2264 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcriρt(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA318609JP1 and AA318609 P11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_31 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2265 below describes the starting and ending position of this segment on each transcript.

Table 2265 - Segment location on transcripts

This segment can be found in both coding and non-codmg regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA318609JP11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609jnode_33 according to the present invention can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2266 below describes the starting and ending position of this segment on each transcript. Table 2266 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA3186O9_P11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_35 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2267 below describes the starting and ending position of this segment on each transcript.

Table 2267 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P1 and AA3186O9_P11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_38 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T9 and AA318609_T23. Table 2268 below describes the starting and ending position of this segment on each transcript.

Table 2268 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above -with-regard -to-the- cluster— itself,- -various-oligonucleotides-were-tested -for-being differentially- expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 2269.

Table 2269 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609_P3. This segment can also be found in the following protein(s): AA3186O9_P11, since it is in the coding region for the corresponding transcript.

Segment cluster AA318609_node_39 according to the present invention can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2270 below describes the starting and ending position of this segment on each transcript. Table 2270 - Segment location on transcripts

This segment can be found in the following protein(s): AA3186O9_P1, AA318609_P3 and AA318609JPl l.

Segment cluster AA318609_node_40 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T23. Table 2271 below describes the starting and ending position of this segment on each transcript. Table 2271 - Segment location on transcripts

Transcript name Segment Segment starting position ending position

AA318609 T23 1572 1681

This segment can be found in the following protein(s): AA3186O9_P11.

Segment cluster AA318609_node_42 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2272 below describes the starting and ending position of this segment on each transcript.

Table 2272 - Segment location on transcripts

This segment can be found in the following protein(s): AA3186O9_P1 and AA318609 P3. Segment cluster AA318609_node_47 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2273 below describes the starting and ending position of this segment on each transcript.

Table 2273 - Segment location on transcripts

This segment can be found in the following protein(s): AA3186O9_P1 and AA318609_P3.

Segment cluster AA318609_node_53 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2274 below describes the starting and ending position of this segment on each transcript.

^~Table ^~22 IT^Segment location on transcripts ^{~~ ~~~}

This segment can be found in the following protein(s): AA318609_Pl and AA318609 P3.

Segment cluster AA318609_node_56 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2275 below describes the starting and ending position of this segment on each transcript.

Table 2275 - Segment location on transcripts 2005/002438

1355

This segment can be found in the following protein(s): AA3186O9_P1 and AA318609_P3.

Segment cluster AA318609_node_58 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609_T9. Table 2276 below describes the starting and ending position of this segment on each transcript.

Table 2276 - Segment location on transcripts

This segment can be found in the following protein(s): AA318609JP1 and

AA318609 P3.

Segment cluster AA318609_node_67 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5 and AA318609 _T9. Table 2277 below describes the starting and ending position of this segment on each transcript.

Table 2277 - Segment location on transcripts

This segment can be found in the following protein(s): AA3186O9_P1 and AA318609 P3. Segment cluster AA318609_node_69 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): AA318609_T5 and AA318609_T9. Table 2278 below describes the starting and ending position of this segment on each transcript.

Table 2278 - Segment location on transcripts

This segment can be found in the following protein(s): AA318609_Pl and AA318609 P3.

Segment cluster AA318609_nodeJ70 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA318609_T5, AA318609_T9 and AA318609_T23. Table 2279 below describes the starting and ending position of this segment on each transcript.

Table 2279^~^Segment location on transcripis^{~ ~~~ ~ ~~ "}

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA318609JP11. This segment can also be found in the following protein(s): AA3186O9_P1 and AA318609_P3, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER AA367524 Cluster AA367524 features 7 transcript(s) and 21 segment(s) of interest, the names for which are given in Tables 2280 and 2281, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2282.

Table 2280 - Transcripts of interest

Transcript Name

AA367524 TO

AA367524 T2

AA367524 T4

AA367524 T6

AA367524 T7

AA367524 T9

AA367524 T12

Table 2281 - Segments of interest

Segment Name

AA367524 node 0

AA367524 node 1

AA367524 node 10

AA367524 node 11

AA367524 node 23

AA367524 node 25

AA367524 node 28

AA367524 node 31

AA367524 node 37

AA367524 node 39

AA367524 node 3

AA367524 node 5

AA367524 node 6

AA367524 node 7

AA367524 node 12

AA367524 node 16

AA367524 node 17

AA367524 node 20

AA367524 node 21

AA367524 node 33

AA367524 node 35 Table 2282 - Proteins of interest

As noted above, cluster AA367524 features 21 segment(s), which were listed in Table 2281 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster AA367524_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T7, AA367524_T9 and AA367524_T12. Table

2283 below describes the starting and ending position of this segment on each transcript. Table 2283 - Segment location on transcripts

This segment can be found in a nort- coding region of transcript(s) that are related to the following protein(s): AA367524JP1.

Segment cluster AA367524_node_l according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T12. Table 2284 below describes the starting and ending position of this segment on each transcript. Table 2284 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA367524JP1.

Segment cluster AA367524_node_10 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0 and AA367524_T6. Table 2285 below describes the starting and ending position of this segment on each transcript.

Table 2285 - Segment location on transcripts

^{" "}This segment carTbe found ^"in a non-coding region of transcripT(s)That are related toThe following protein(s): AA367524JP1.

Segment cluster AA367524_node_l 1 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0. Table 2286 below describes the starting and ending position of this segment on each transcript.

Table 2286 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA367524_P1. Segment cluster AA367524_node_23 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2287 below describes the starting and ending position of this segment on each transcript.

Table 2287 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524_P1.

Segment cluster AA367524_node_25 according to the present invention is supported by

33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524_T6, AA367524_T7, AA367524_T9 and AA367524JN2. Table 2288 below describes the starting and ending position of this segment on each transcript.

Table 2288 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524_P1. Segment cluster AA367524_node_28 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524_T6, AA367524 J7, AA367524_T9 and AA367524_T12. Table 2289 below describes the starting and ending position of this segment on each transcript.

Table 2289 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524_P1.

Segment cluster AA367524_node_31 according to the present invention is supported by

37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2290 below describes the starting and ending position of this segment on each transcript.

Table 2290 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524_P1. Segment cluster AA367524_node_37 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2291 below describes the starting and ending position of this segment on each transcript.

Table 2291 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524_P1.

Segment cluster AA367524_node_39 according to the present invention is supported by

42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524JTO, AA367524JI2, AA367524_T4, AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2292 below describes the starting and ending position of this segment on each transcript. Table 2292 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524JP1. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster AA367524_node_3 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T7 and AA367524_T9. Table 2293 below describes the starting and ending position of this segment on each transcript.

Table 2293 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA367524JP1.

Segment cluster AA367524_node_5 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T2 and AA367524_T4. Table 2294 below describes the starting and ending position of this segment on each transcript.

Table 2294 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA367524JP1.

Segment cluster AA367524_node_6 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcnpt(s): AA367524_T4. Table 2295 below describes the starting and ending position of this segment on each transcript.

Table 2295 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA367524JP1.

Segment cluster AA367524_node_7 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T4 and AA367524_T9. Table 2296 below describes the starting and ending position of this segment on each transcript.

Table 2296 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA367524_P1.

Segment cluster AA367524_node_12 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2 and AA367524_T4. Table 2297 below describes the starting and ending position of this segment on each transcript.

Table 2297 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protem(s): AA367524JP1.

Segment cluster AA367524_node__16 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2298 below describes the starting and ending position of this segment on each transcript.

Table 2298 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524_P1.

Segment cluster AA367524_node_17 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524 J6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2299 below describes the starting and ending position of this segment on each transcript.

Table 2299 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524JP1.

Segment cluster AA367524_node__20 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2300 below describes the starting and ending position of this segment on each transcript.

Table 2300 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524JP1.

Segment cluster AA367524_node_21 according to the present invention is supported by

28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4,

AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2301 below describes the starting and ending position of this segment on each transcript.

Table 2301 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524_P1.

Segment cluster AA367524_node_33 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4, AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2302 below describes the starting and ending position of this segment on each transcript.

Table 2302 - Segment location on transcripts

This segment can be found in the following protein(s): AA367524_P1.

Segment cluster AA367524_node_35 according to the present invention is supported by

44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA367524_T0, AA367524_T2, AA367524_T4,

AA367524_T6, AA367524_T7, AA367524_T9 and AA367524_T12. Table 2303 below describes the starting and ending position of this segment on each transcript.

Table 2303 - Segment location on transcripts

This segment can be' found in the following protein(s): AA367524_P1.

DESCRIPTION FOR CLUSTER AA563651

Cluster AA563651 features 5 transcript(s) and 7 segment(s) of interest, the names for which are given in Tables 2304 and 2305, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2306.

Table 2304 - Transcripts of interest

Transcript Name

AA563651 TO

AA563651 Tl

AA563651 T2

AA563651 T3

AA563651 T4

Table 2305 - Segments of interest

Segment Name

AA563651 node 0

AA563651 node 2

AA563651 node 4

AA563651 node 6

AA563651 node 7

AA563651 node 3

AA563651 node 5

Table 2306 - Proteins of interest

Cluster AA563651 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 60 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 60 and Table 2307. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and lung malignant tumors.

Table 2307 - Normal tissue distribution

Table 2308 - P values and ratios for expression in cancerous tissue

As noted above, cluster AA563651 features 7 segment(s), which were listed in Table

2305 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster AA563651_node_0 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA563651_T0, AA563651_T1, AA563651_T2, c56-36-5l3T3-and-A-A56365-liT4. Table^~2309-below-describes1:he-starting-and-endiπg position- of this segment on each transcript.

Table 2309 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA563651_P1. This segment can also be found in the following protein(s): AA563651JP2, since it is in the coding region for the corresponding transcript. Segment cluster AA563651_node_2 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA563651_T0, AA563651_T1, AA563651_T2 and AA563651_T3. Table 2310 below describes the starting and ending position of this segment on each transcript.

Table 2310 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA563651JP1.

Segment cluster AA563651_node_4 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA563651_T0, AA563651_TT, AA563651_T2 and AA563651_T3. Table 2311 below describes the starting and ending position of this segment on each transcript.

Table 2311 - Segment location on transcripts

This segment can be found in the following protein(s): AA563651_P1.

Segment cluster AA563651_node_6 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA563651_T0, AA563651_ T1, AA563651_T2 and AA563651_T4. Table 2312 below describes the starting and ending position of this segment on each transcript.

Table 2312 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA563651_P1. This segment can also be found in the following protein(s): AA563651_P2, since it is in the coding region for the corresponding transcript.

Segment cluster AA563651_node_7 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA563651_T0, AA563651_T1, AA563651_T2,

AA563651_T3 and AA563651_T4. Table 2313 below describes the starting and ending position of this segment on each transcript

Table 2313 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA563651_P1 and AA563651JP2. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster AA563651_node_3 according to the present invention can be found in the following transcript(s): AA563651_T0, AA563651_T2 and AA563651_T3. Table 2314 below describes the starting and ending position of this segment on each transcript.

Table 2314 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA563651_P1.

Segment cluster AA563651_node_5 according to the present invention can be found in the following transcript(s): AA563651_T0, AA563651_T1, AA563651_T2, AA563651_T3 and AA563651_T4. Table 2315 below describes the starting and ending position of this segment on each transcript.

Table 2315 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA563651_P1. This segment can also be found in the following protein(s): AA563651_P2, since it is in the coding region for the corresponding transcript. DESCRIPTION FOR CLUSTER Dl 1717

Cluster Dl 1717 features 7 transcript(s) and 31 segment(s) of interest, the names for which are given in Tables 2316 and 2317, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2318. Table 2316 - Transcripts of interest

Transcript Name

Dl 1717 TO

D11717 Tl

D11717 T4

D11717 T8

Dl 1717 T9

D11717 TI l

D11717 T14

Table 2317 - Segments of interest

SegmentName

D11717 node 12

D11717 node 13

D11717 node 14

D11717 node 15

D11717 node 16

D11717 node 20

D11717 node 21

D11717 node 28

D11717 node 37

D11717 node 2

D11717 node 3

D11717 node 4

D11717 node 5

D11717 node 19

D11717 node 22

D11717 node 23

D11717 node 24 D11717 node 25

D11717 node 26

D11717 node 27

D11717 node 29

D11717 node 30

D11717 node 31

D11717 node 32

D11717 node 33

D11717 node 34

D11717. node _35

D11717 node 36

D11717 node 38

D11717 node 39

D11717 node 40

Table 2318 - Proteins of interest

These sequences are variants of the known protein Growth/differentiation factor 15 precursor (SwissProt accession identifier GDFF_HUMAN; known also according to the synonyms GDF-15; Placental bone morphogenic protein; Placental TGF-beta; Macrophage inhibitory cytokine- 1; MIC-I; Prostate differentiation factor; NSAID- regulated protein 1; NRG- 1), referred to herein as the previously known protein.

The sequence for protein Growth/differentiation factor 15 precursor is given at the end of the application, as "Growth/differentiation factor 15 precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2319.

Table 2319 - Amino acid mutations for Known Protein

Protein Growth/differentiation factor 15 precursor localization is believed to be Secreted (Probable).

5 A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Anticancer.

The following GO Annotation(s) apply to the previously known protein. The following

10 annotation(s) were found: signal transduction; TGFbeta receptor signaling pathway; cell-cell signaling, which are annotation(s) related to Biological Process; cytokine; growth factor, which are annotation(s) related to Molecular Function; and extracellular, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl 15 Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available — — — frΘm-<http:-//w-wwτnebi.-nhnrnihτgov/projects/LocusLink/>:

Cluster Dl 1717 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given 20 according to the previously described methods. The teπn "number" in the left hand column of the table and the numbers on the yaxis of Figure 61 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

25 Overall, the following results were obtained as shown with regard to the histograms in

Figure 61 and Table 2320. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, colorectal cancer, epithelial malignant tumors, a mixture of malignant tumors from different tissues, myosarcoma and gastric carcinoma. Table 2320 - Normal tissue distribution

Table 2321- P values and ratios for expression in cancerous tissue

As noted above, cluster Dl 1717 features 31 segment(s), which were listed in Table 2317 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster D11717_node_12 according to the present invention is supported by 159 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2322 below describes the starting and ending position of this segment on each transcript.

Table 2322 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7 and D11717_P8. This segment can also be found in the following protein(s): D11717JP16, D11717_P6 and D11717_P11, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_13 according to the present invention is supported by 188 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_ T11 and D11717_T14. Table 2323 below describes the starting and ending position of this segment on each transcript. Table 2323 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7 and D11717JP8. This segment can also be found in the following protein(s): D11717JP16, D11717JP2, D11717JP6 and D11717JP11, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_14 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T9 and D11717_T11. Table 2324 below describes the starting and ending position of this segment on each transcript.

Table 2324 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s): Dl 1717_P8, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_15 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T9. Table 2325 below describes the starting and ending position of this segment on each transcript.

Table 2325 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1717_P7.

Segment cluster D11717_node_16 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T9. Table 2326 below describes the starting and ending position of this segment on each transcript.

Table 2326 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1717_P7.

Segment cluster D11717jnode_20 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T9. Table 2327 below describes the starting and ending position of this segment on each transcript.

Table 2327 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1717_P7. Segment cluster D11717_node_21 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T9. Table 2328 below describes the starting and ending position of this segment on each transcript.

Table 2328 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1717__P7.

Segment cluster D11717_node_28 according to the present invention is supported by 133 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8,

D11717_T9, D11717_T11 and D11717_T14. Table 2329 below describes the starting and ending position of thTs^~segment on eaclTtranscript^{" " ~~ ~~ ~~ ~}

Table 2329 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s):

D11717_P16, D11717_P2, D11717_P6, D11717_P8 and D11717JP11, since it is in the coding region for the corresponding transcript. Segment cluster D11717_node_37 according to the present invention is supported by 144 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): D1 1717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2330 below describes the starting and ending position of this segment on each transcript.

Table 2330 - Segment location on transcripts

This segment can be found in the following protein(s): D11717_P16, D11717_P2, D11717_P6, D11717_P7, D11717_P8 and D11717_Pl l.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster D11717_node_2 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2331 below describes the starting and ending position of this segment on each transcript.

Table 2331 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717JP16, D1 1717_P2, D11717_P6, D11717_P7, D11717_P8 and D11717_P11.

Segment cluster D11717_node_3 according to the present invention can be found in the following transcript(s): D11717JTO, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2332 below describes the starting and ending position of this segment on each transcript.

Table 2332 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Dl 1717JP16, Dl 1717_P6, Dl 1717_P7, Dl 1717_P8 and Dl 1717JP11.

Segment cluster D11717_node_4 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717JN, D11717_T4, D11717_T8,

D11717_T9, D11717_T11 and D11717_T14. Table 2333 below describes the starting and ending position of this segment on each transcript.

Table 2333 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P16, D11717_P6, D11717_P7, D11717_P8 and D11717_P11. This segment can also be found in the following protein(s): Dl 1717_P2, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_5 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8,

D11717_T9, D11717_T11 and D11717_T14. Table 2334 below describes the starting and ending position of this segment on each transcript.

Table 2334 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D11717_P16, D11717_P6, D11717_P7, D11717_P8 and D11717_P11. This segment can also be found in the following protein(s): Dl 1717_P2, since it is in the coding region for the corresponding transcript. Segment cluster D11717jnode_19 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T9. Table 2335 below describes the starting and ending position of this segment on each transcript.

Table 2335 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7.

Segment cluster D11717_node_22 according to the present invention is supported by 128 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2336 below describes the starting and ending position of this segment on each transcript. Table 2336 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D11717JP7. This segment can also be found in the following protein(s): D11717_P16, D11717_P2, D11717_P6, D11717_P8 and D11717_P11, since it is in the coding region for the corresponding transcript. Segment cluster Dl 1717_node_23 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9 and Dl 1717 T11. Table 2337 below describes the starting and ending position of this segment on each transcript.

Table 2337 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s): Dl 1717JP16, Dl 1717_P2, Dl 1717_P6 and Dl 1717JP8, since it is in the coding region for the corresponding transcript. _

Segment cluster D11717_node_24 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717__T1, D11717_T4, D11717_T8,

D11717_T9 and D11717_T11. Table 2338 below describes the starting and ending position of this segment on each transcript.

Table 2338 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s): D11717_P16, D11717_P2, D11717JP6 and D11717_P8, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_25 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9 and D11717_T11. Table 2339 below describes the starting and ending position of this segment on each transcript.

Table 2339 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s): D11717_P16, D11717_P2, D11717_P6 and D11717JP8, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_26 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2340 below describes the starting and ending position of this segment on each transcript. 5 002438

1388

Table 2340 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s):

D11717JU6, D11717J^>2, D11717_P6, D11717_P8 and D11717JP11, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_27 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2341 bebw describes the starting and ending position of this segment on each transcript.

Table 2341 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717JP7. This segment can also be found in the following protein(s): D11717J^>16, D11717_P2, D11717_P6, D1 1717_P8 and D11717_P11, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_29 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2342 below describes the starting and ending position of this segment on each transcript.

Table 2342 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s): D11717JP16, D11717_P2, D11717_P6, D11717JP8 and D11717_P11, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_30 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2343 below describes the starting and ending position of this segment on each transcript. Table 2343 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s): D11717_P16, D11717_P2, D11717_P6, D11717_P8 and D11717JP11, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_31 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T9, D11717_T11 and D11717_T14. Table 2344 below describes the starting and ending position of this segment on each transcript.

Table 2344 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s):

D11717_P16, D11717_P2, D11717_P8 and D11717JP11, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_32 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T9, D11717_T11 and Dl 1717 T14. Table 2345 below describes the starting and ending position of this segment on each transcript.

Table 2345 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717_P7. This segment can also be found in the following protein(s): D11717_P16, D11717_P2, D11717_P8 and D11717_P11, since it is in the coding region for the corresponding transcript.

Segment cluster D11717_node_33 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T9, D11717_T11 and D11717_T14. Table 2346 below describes the starting and ending position of this segment on each transcript.

Table 2346 - Segment location on transcripts

This segment can be found in the following protein(s): D11717_P16, D11717_P2, Dl 1717_P7, Dl 1717_P8 and Dl 1717_P11. Segment cluster D11717_node_34 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T9, D11717_T11 and D11717_T14. Table 2347 below describes the starting and ending position of this segment on each transcript.

Table 2347 - Segment location on transcripts

This segment can be found in the following protein(s): D11717_P16, D11717_P2, D11717_P7, D11717_P8 and D11717_Pl l.

Segment cluster D11717_node_35 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2348 below describes the starting and ending position of this segment on each transcript. Table 2348 - Segment location on transcripts

This segment can be found in the following protein(s): D11717_P16, D11717JP2, Dl 1717_P6, Dl 1717_P7, Dl 1717_P8 and Dl 1717JP11. Segment cluster D11717_node_36 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D1 1717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2349 below describes the starting and ending position of this segment on each transcript.

Table 2349 - Segment location on transcripts

This segment can be found in the following protein(s): D11717_P16, D11717_P2, D11717_P6, D11717_P7, D11717_P8 and D11717_Pl l.

Segment cluster D11717_node_38 according to the present invention is supported by 130 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8,

D11717_T9, D11717_T11 and D11717_T14. Table 2350 below describes the starting and ending position of this segment on each transcript.

Table 2350 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717JP16, D11717_P2, D11717_P6, D11717_P7, D11717_P8 and D11717 P11.

Segment cluster D11717_node_39 according to the present invention can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2351 below describes the starting and ending position of this segment on each transcript.

Table 2351 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D11717J^>16, D11717_P2, D11717_P6, D11717_P7, D11717_P8 and D11717 PI l.

Segment cluster D11717__node_40 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D11717_T0, D11717_T1, D11717_T4, D11717_T8, D11717_T9, D11717_T11 and D11717_T14. Table 2352 below describes the starting and ending position of this segment on each transcript. Table 2352 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D11717JP16, D11717_P2, D11717_P6, D11717_P7, D11717_P8 and D11717 PI l.

DESCRIPTION FOR CLUSTER D12392

Cluster D 12392 features 6 transcript(s) and 23 segment(s) of interest, the names for which are given in Tables 2353 and 2354, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2355.

Table 2353 - Transcripts of interest

Table2354-Segmentsofinterest

SegmentName

D12392 node 0

D12392 node 7

D12392 node 9

D12392 node 13

D12392 node 21

D12392 node 22

D12392 node 26

D12392 node 30

D12392 node 32

D12392 node 35

D12392 node 2 D12392 node 3

D12392 node 5

D12392 node 14

D12392 node 15

D12392 node 17

D12392 node 18

D12392 node 19

D12392 node 24

D12392 node 29

D12392 node 33

D12392 node 36

D 12392 node 37

Table 2355 - Proteins of interest

Cluster D12392 can be used as a diagnostic marker according to overexpression of -transcripts-ofi-this-cluster-in-cancer-.-Expression-ot-such-transcripts in normal -tissues is-also given- according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 62 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 62 and Table 2356. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and skin malignancies.

Table 2356 - Normal tissue distribution

Table 2357 - P values and ratios for expression in cancerous tissue

As noted above, cluster D12392 features 23 segment(s), which were listed in Table 2354 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster D12392_node_0 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T15. Table 2358 below describes the starting and ending position of this segment on each transcript.

Table 2358 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P12.

Segment cluster D12392jnode_7 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be ending position of this segment on each transcript.

Table 2359 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster D12392_node_9 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T15. Table 2360 below describes the starting and ending position of this segment on each transcript. Table 2360 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P12.

Segment cluster D12392_node_13 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12. Table 2361 below describes the starting and ending position of this segment on each transcript.

Table 2361 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12392_P9.

Segment cluster D12392_node_21 according to the present invention is supported T5y 2 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): D12392_T13. Table 2362 below describes the starting and ending position of this segment on each transcript.

Table 2362 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12392_P11.

Segment cluster D12392_node_22 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12 and D12392_T13. Table 2363 below describes the starting and ending position of this segment on each transcript.

Table 2363 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9 and D12392_P11.

Segment cluster D12392_node_26 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12 and D12392_T13. Table 2364 below describes the starting and ending position of this segment on each transcript.

Table 2364 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9 and D12392_P11.

Segment cluster D12392_node_30 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12 and D12392_T13. Table 2365 below describes the starting and ending position of this segment on each transcript.

Table 2365 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9 and D12392_P11. Segment cluster D12392_node_32 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T14. Table 2366 below describes the starting and ending position of this segment on each transcript.

Table 2366 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster D12392_node_35 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T16 and D12392_T17. Table 2367 below describes the starting and ending position of this segment on each transcript.

Table 2367 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster D12392_node_2 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T15. Table 2368 below describes the starting and ending position of this segment on each transcript. Table 2368 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P12.

Segment cluster D12392_node_3 according to the present invention can be found in the following transcript(s): D12392_T15. Table 2369 below describes the starting and ending position of this segment on each transcript.

Table 2369 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P12.

Segment cluster D12392_node_5 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T15. Table 2370 below describes the starting and ending position of this segment on each transcript.

Table 2370 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P12.

Segment cluster D12392_node_14 according to the present invention can be found in the following transcript(s): D12392_T12. Table 2371 below describes the starting and ending position of this segment on each transcript.

Table 2371 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12392_P9.

Segment cluster D12392__node_15 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12. Table 2372 below describes the starting and ending position of this segment on each transcript.

Table 2372 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12392_P9.

Segment cluster D12392_node_17 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12. Table 2373 below describes the starting and ending position of this segment on each transcript.

Table 2373 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12392_P9.

Segment cluster D12392_node_18 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12. Table 2374 below describes the starting and ending position of this segment on each transcript.

Table 2374 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12392_P9.

Segment cluster D12392_node_19 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12. Table 2375 below describes the starting and ending position of this segment on each transcript.

Table 2375 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9.

Segment cluster D12392_node_24 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12 and D12392_T13. Table 2376 below describes the starting and ending position of this segment on each transcript.

Table 2376 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9 and D12392_P11. Segment cluster D12392_node_29 according to the present invention can be found in the following transcript(s): D12392_T12 and D12392_T13. Table 2377 below describes the starting and ending position of this segment on each transcript.

Table 2377 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9 and D12392_P11.

Segment cluster D12392_node_33 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12, D12392_T13 and D12392_T14. Table 2378 below describes the starting and ending position of this segment on each transcript.

Table 2378 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9 and D12392JP11.

Segment cluster D12392_node_36 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12, D12392_T13, D12392_T14, D12392_T16 and D12392_T17. Table 2379 below describes the starting and ending position of this segment on each transcript.

Table 2379 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9 and D12392_P11.

Segment cluster D12392_node_37 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12392_T12, E42392_T13, D12392_T14, D12392_T16 and D12392_T17. Table 2380 below describes the starting and ending position of this segment on each transcript.

Table 2380 - Segment location on transcripts

This segment can be found in the following protein(s): D12392_P9 and D12392JP11.

DESCRIPTION FOR CLUSTER D31004

Cluster D31004 features 4 transcript(s) and 17 segment(s) of interest, the names for which are given in Tables 2381 and 2382, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2383. Table 2381 - Transcripts of interest

Transcript Name

D31004 T6

D31004 Tl 6

D31004 T19 D31004 T26

Table 2382 - Segments of interest

SegmentName

D31004 node 12

D31004 node 13

D31004 node 15

D31004 node 19

D31004 node 20

D31004 node 21

D31004 node 23

D31004 node 25

D31004 node 27

D31004 node 29

D31004 node 30

D31004 node 32

D31004 node 14

D31004 node 17

D31004 node 22

D31004 node 24

D31004 node 26

Table 2383 - Proteins of interest

These sequences are variants of the known protein Thyroid transcription factor 1 (SwissProt accession identifier TTF1_HUMAN; known also according to the synonyms Thyroid nuclear factor 1; TTF-I; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A), referred to herein as the previously known protein.

Protein Thyroid transcription factor 1 is known or believed to have the following function(s): Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. The sequence for protein Thyroid transcription factor 1 is given at the end of the application, as "Thyroid transcription factor 1 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2384. Table 2384 - Amino acid mutations for Known Protein

Protein Thyroid transcription factor 1 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription regulation, which are annotation(s) related to Biological Process; transcription factor; transcriptional activator, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslmk, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster D31004 features 17 segment(s), which were listed in Table 2382 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster D31004_node_12 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T16 and D31004_T26. Table 2385 below describes the starting and ending position of this segment on each transcript.

Table 2385 - Segment location on transcripts

This segment can be found in the following protein(s): D31004_P5.

Segment cluster D31004_node_13 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T16 and D31004_T26. Table 2386 below describes the starting and ending position of this segment on each transcript.

Table 2386 - Segment location on transcripts

This segment can be found in the following protein(s): D31004_P5.

Segment cluster D31004_node_15 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T16 and D31004_T26. Table 2387 below describes the starting and ending position of this segment on each transcript.

Table 2387 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004_P5. Segment cluster D31004 node_l 9 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T6. Table 2388 below describes the starting and ending position of this segment on each transcript.

Table 2388 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster D31004_node_20 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T6 and D31004_T16. Table 2389 below describes the starting and ending position of this segment on each transcript.

Table 2389 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004_P5.

Segment cluster D31004_node_21 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T6 and D31004_T16. Table 2390 below describes the starting and ending position of this segment on each transcript.

Table 2390 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D31004JP5.

Segment cluster D31004_node_23 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T6 and D31004_T16. Table 2391 below describes the starting and ending position of this segment on each transcript.

Table 2391 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004_P5.

Segment cluster D31004_node_25 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T6, D31004_T16 and D31004_T26. Table 2392 below describes the starting and ending position of this segment on each transcript.

Table 2392 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004_P5. Segment cluster D31004_node_27 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T16 and D31004_T26. Table 2393 below describes the starting and ending position of this segment on each transcript.

Table 2393 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004_P5.

Segment cluster D31004jnode_29 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T19. Table 2394 below describes the starting and ending position of this segment on each transcript. TaSIe 2 '3V4^^~Seginent locaTϊoh on transcripts — — — - — — - -

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster D31004_node_30 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T6 and D31004_T19. Table 2395 below describes the starting and ending position of this segment on each transcript.

Table 2395 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster D31004_node_32 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T6 and D31004_T19. Table 2396 below describes the starting and ending position of this segment on each transcript.

Table 2396 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and '. so are included in a separate description.

Segment cluster D31004_node_14 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T16 and D31004_T26. Table 2397 below describes the starting and ending position of this segment on each transcript.

Table 2397 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004_P5. Segment cluster D31004__node_17 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T16 and D31004_T26. Table 2398 below describes the starting and ending position of this segment on each transcript.

Table 2398 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004_P5.

Segment cluster D31004_node_22 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T6 and D31004_T16. Table 2399 below describes the starting and ending position of this segment on each transcript. TάBleϋTPy^Se^'gmentlocation on transcripts ^{~ " "}

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004_P5.

Segment cluster D31004_node_24 according to the present invention can be found in the following transcript(s): D31004_T6, D31004_T16 and D31004_T26. Table 2400 below describes the starting and ending position of this segment on each transcript.

Table 2400 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004JP5.

Segment cluster D31004_node_26 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D31004_T16 and D31004_T26. Table 2401 below describes the starting and ending position of this segment on each transcript.

Table 2401 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D31004JP5.

DESCRIPTION FOR CLUSTER D62617

Cluster D62617 features 1 transcript(s) and 2 segment(s) of interest, the names for which are given in Tables 2402 and 2403, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2404.

Table 2402 - Transcripts of interest

Transcript Name

D62617 TO

Table 2403 - Segments of interest

Segment Name D62617 node 0

D62617 node 2

Table 2404 - Proteins of interest

5 The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster D62617. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 63 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that 10 category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 63, concerning the number of heart-specific clones in libraries/sequences.

This cluster was found to be selectively expressed in heart for the following reasons: in a

-1-5 comparison-of the-ratio-of-expression-of— the_cluster— in— heart-spedfic-ESTs-to-the -overall - expression of the cluster in non-heart ESTs, which was found to be 11.4; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 5.6; and fisher exact test P-values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found 20 to be 3.60E-05.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to 25 non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle -specific ESTs which was found to be 11.4, which clearly supports specific expression in heart tissue. As noted above, cluster D62617 features 2 segment(s), which were listed in Table 2403 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster D62617jnode_0 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D62617_T0. Table 2405 below describes the starting and ending position of this segment on each transcript.

Table 2405 - Segment location on transcripts

The previously - described tfanscπpTsTor these segment(s) do not co3eTόr protein.

Segment cluster D62617_node_2 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D62617_T0. Table 2406 below describes the starting and ending position of this segment on each transcript.

Table 2406 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER F13779 Cluster F 13779 features 1 transcript(s) and 32 segment(s) of interest, the names for which are given in Tables 2407 and 2408, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2409.

Table 2407 - Transcripts of interest

Transcript Name

F13779 Tl

Table 2408 - Segments of interest

F 13779 node 42

Fl 3779 node 43

Table 2409 - Proteins of interest

Cluster F 13779 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 64 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 64 and Table 2410. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and skin malignancies.

Table 2410 - Normal tissue distribution

Table 2411 - P values and ratios for expression in cancerous tissue

As noted above, cluster F 13779 features 32 segment(s), which were listed in Table 2408 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster F13779_nodeJ) according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2412 below describes the starting and ending position of this segment on each transcript.

Table 2412 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779_P1.

Segment cluster F13779_node_9 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2413 below describes the starting and ending position of this segment on each transcript. Table 2413 - Segment location on transcripts

This segment can be found in the following protein(s): F13779_P1.

Segment cluster F13779_node_l l according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2414 below describes the starting and ending position of this segment on each transcript.

Table 2414 - Segment location on transcripts

This segment can be found in the following protein(s): F13779JP1.

Segment cluster F13779_node_13 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2415 below describes the starting and ending position of this segment on each transcript.

Table 2415 - Segment location on transcripts

This segment can be found in the following protein(s): F13779_P1.

Segment cluster F13779_node_31 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2416 below describes the starting and ending position of this segment on-each transcript. — - — — — - — ■ — - — . — .

Table 2416- Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F13779JP1.

Segment cluster F13779_node_32 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2417 below describes the starting and ending position of this segment on each transcript. Table 2417 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F 13779 JPl.

Segment cluster F13779_node_33 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2418 below describes the starting and ending position of this segment on each transcript.

Table 2418 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779JP1.

Segment cluster F13779_node_34 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2419 below describes the starting and ending position of this segment on each transcript.

Table 2419 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779_P1.

Segment cluster F13779_node_39 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2420 below describes the starting and ending position of this segment on each transcript.

Table 2420 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F13779JP1.

Segment cluster F13779_node_41 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2421 below describes the starting and ending position of this segment on each transcript.

Table 2421 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s) : F 13779_P 1.

Segment cluster F13779_node_44 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2422 below describes the starting and ending position of this segment on each transcript.

Table 2422 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F13779JP1. Segment cluster F13779_node_45 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2423 below describes the starting and ending position of this segment on each transcript.

Table 2423 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779_P1.

Segment cluster F13779_node_46 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2424 below describes the starting and ending position of this segment on each transcript.

Table 2424 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779_P1.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster F13779_node_6 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2425 below describes the starting and ending position of this segment on each transcπpt.

Table 2425 - Segment location on transcripts

This segment can be found in the following protein(s): F13779JP1.

Segment cluster F13779_node_7 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2426 below describes the starting and ending position of this segment on each transcript.

Table 2426 - Segment location on transcripts

This segment can be found in the following protein(s): F13779_P1.

Segment cluster F13779_node_15 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2427 below describes the starting and ending position of this segment on each transcript.

Table 2427 - Segment location on transcripts

This segment can be found in the following protein(s): F13779JP1.

Segment cluster F13779__node_17 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2428 below describes the starting and ending position of this segment on each transcript.

Table 2428 - Segment location on transcripts

This segment can be found in the following protein(s): F13779JP1.

Segment cluster F13779_node_20 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2429 below describes the starting and ending position of this segment on each transcript.

Table 2429 - Segment location on transcripts

This segment can be found in the following protein(s): F13779JP1.

Segment cluster F13779_node_22 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2430 below describes the starting and ending position of this segment on each transcript.

Table 2430 - Segment location on transcripts

This segment can be found in the following protein(s): F13779_P1. Segment cluster F13779_node_25 according to the present invention can be found in the following transcript(s): F13779_T1. Table 2431 below describes the starting and ending position of this segment on each transcript.

Table 2431 - Segment location on transcripts

This segment can be found in the following protein(s): F13779JP1.

Segment cluster F13779_node_26 according to the present invention can be found in the following transcript(s): F13779_T1. Table 2432 below describes the starting and ending position of this segment on each transcript.

Table 2432 - Segment location on transcripts

This segment can be found in the following protein(s): F13779_P1.

Segment cluster F13779_node_27 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F 13779 _Tl. Table 2433 below describes the starting and ending position of this segment on each transcript.

Table 2433 - Segment location on transcripts

This segment can be found in the following protein(s): F13779JP1.

Segment cluster F13779_node_28 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2434 below describes the starting and ending position of this segment on each transcript.

Table 2434 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779JP1.

Segment cluster F13779jnode_29 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2435 below describes the starting and ending position of this segment on each transcript.

Table 2435 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779_P1.

Segment cluster F13779_node_30 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2436 below describes the starting and ending position of this segment on each transcript.

Table 2436 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F13779JP1. Segment cluster F13779_node_35 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2437 below describes the starting and ending position of this segment on each transcript.

Table 2437 ~ Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779_P1.

Segment cluster F13779_node_36 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2438 bebw describes the starting and ending position of this segment on each transcript. Table 2438 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779_P1.

Segment cluster F13779_node_37 according to the present invention can be found in the following transcript(s): F13779_T1. Table 2439 below describes the starting and ending position of this segment on each transcript.

Table 2439 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779JP1.

Segment cluster F13779_node_38 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): F13779_T1. Table 2440 below describes the starting and ending position of this segment on each transcript.

Table 2440 - Segment location on transcripts

10

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779JP1.

Segment cluster F13779_node_40 according to the present invention can be found in the

_15. following-transcript(s): F137-7-9_₁Tk-Table-2441-below-describes the-starting and ending position- of this segment on each transcript.

Table 2441 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the 20 following protein(s): F13779JP1.

Segment cluster F13779_node_42 according to the present invention can be found in the following transcript(s): F13779_T1. Table 2442 below describes the starting and ending position of this segment on each transcript.

25 Table 2442 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779JP1.

Segment cluster F13779__node_43 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F13779_T1. Table 2443 below describes the starting and ending position of this segment on each transcript.

Table 2443 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F13779_P1.

DESCRIPTION FOR CLUSTER H79892

Cluster H79892 features 4 transcript(s) and 13 segment(s) of interest, the names for which are given in Tables 2444 and 2445, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2446. Table 2444 - Transcripts of interest

Transcript Name

H79892 T2

H79892 T3

H79892 T4

H79892 T5

Table 2445 - Segments of interest SegmentName

H79892 node 0

H79892 node 4

H79892 node 6

H79892 node 8

H79892 node 9

H79892 node 11

H79892 node 13

H79892 node 14

H79892 node 18

H79892 node 19

H79892 node 2

H79892 node 16

H79892 node 20

Table 2446 - Proteins of interest

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster H79892. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 65 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 65, concerning the number of heart-specific clones in libraries/sequences.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non-heart ESTs, which was found to be 22.6; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific

ESTs which was found to be 55.5; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 5.40E-04.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle -specific ESTs which was found to be 22.6, which clearly supports specific expression in heart tissue.

As noted above, cluster H79892 features 13 segment(s), which were listed in Table 2445 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of-particular-interest-A description-of-each-segment according-to-the_present-invention JSJIOWL. provided.

Segment cluster H79892_node_0 according to the present invention s supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2, H79892_T3 and H79892_T5. Table 2447 below describes the starting and ending position of this segment on each transcript.

Table 2447 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H79892_P3. This segment can also be found in the following protein(s): H79892_P1 and H79892_P2, since it is in the coding region for the corresponding transcript.

Segment cluster H79892_node_4 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2 and H79892_T3. Table 2448 below describes the starting and ending position of this segment on each transcript.

Table 2448 - Segment location on transcripts

This segment can be found in the following protein(s): H79892_P1 and H79892JP2.

Segment cluster H79892_node_6 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be -found4n4he-followmg-transGr-ipt(s);-H79892-T-2-and-H-798-92— T3. -Table 2449 below-descr-ibes - the starting and ending position of this segment on each transcript.

Table 2449 - Segment location on transcripts

This segment can be found in the following protein(s): H79892JP1 and H79892_P2.

Segment cluster H79892_node_8 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2 and H79892_T3. Table 2450 below describes the starting and ending position of this segment on each transcript.

Table 2450 - Segment location on transcripts

This segment can be found in the following protein(s): H79892_P1 and H79892_P2.

Segment cluster H79892_node_9 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T3. Table 2451 below describes the starting and ending position of this segment on each transcript.

Table 2451 - Segment location on transcripts

This segment can be found in the following protein(s): H79892_P2.

-Segment Gluster-H79892-nDde-14-aGCording-to-the-present_mvention-is-supported-by— 1-1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2. Table 2452 below describes the starting and ending position of this segment on each transcript.

Table 2452 - Segment location on transcripts

This segment can be found in the following protein(s): H79892_P1.

Segment cluster H79892_node_13 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T4. Table 2453 below describes the starting and ending position of this segment on each transcript. Table 2453 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster H79892_node_14 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2, H79892_T4 and H79892_T5. Table 2454 below describes the starting and ending position of this segment on each transcript.

Table 2454 - Segment location on transcripts

This segment can be found in the following protein(s): H7-9892_P1 and H79892_P3.

Segment cluster H79892_node_l 8 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2 and H79892_T5. Table 2455 below describes the starting and ending position of this segment on each transcript.

Table 2455 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H79892_P1 and H79892_P3. Segment cluster H79892_node_19 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2 and H79892_T5. Table 2456 below describes the starting and ending position of this segment on each transcript.

Table 2456 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H79892_P1 and H79892_P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster H79892_node_2 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2 and H79892_T3. Table 2457 below describes the starting and ending position of this segment on each transcript.

Table 2457 - Segment location on transcripts

This segment can be found in the following ρrotein(s): H79892_P1 and H79892_P2.

Segment cluster H79892_node_16 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2, H79892_T4 and H79892_T5. Table 2458 below describes the starting and ending position of this segment on each transcript.

Table 2458 - Segment location on transcripts

This segment can be found in the following protein(s): H79892_P1 and H79892_P3.

Segment cluster H79892_node_^20 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H79892_T2, H79892_T4 and H79892_T5. Table 2459 below describes the starting and ending position of this segment on each transcript.

Table 2459 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H79892_P1 and H79892_P3.

DESCRIPTION FOR CLUSTER HSAE2

Cluster HSAE2 features 13 transcript(s) and 58 segment(s) of interest, the names for which are given in Tables 2460 and 2461, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2462.

Table 2460 - Transcripts of interest

Transcript Name HSAE2 Tl

HSAE2 T4

HSAE2 T7

HSAE2 T8

HSAE2 TlO

HSAE2 TI l

HSAE2 T18

HSAE2 T23

HSAE2 T29

HSAE2 T32

HSAE2 T34

HSAE2 T47

HSAE2 T48

Table 2461 - Segments of interest

HSAE2 node 8

HSAE2 node 1 1

HSAE2 node 15

HSAE2 node 16

HSAE2 node 18

HSAE2 node 19

HSAE2 node 20

HSAE2 node 24

HSAE2 node 38

HSAE2 node 40

HSAE2 node 41

HSAE2 node 44

HSAE2 node 45

HSAE2 node 46

HSAE2 node 48

HSAE2 node 49

HSAE2 node 50

HSAE2 node 51

HSAE2 node 56

HSAE2 node 57

HSAE2 node 58

HSAE2 node 65

HSAE2 node 66

HSAE2_ϊiode _6.7..

HSAE2 node 69

HSAE2 node 70

HSAE2 node 78

HSAE2 node 79

HSAE2 node 80

HSAE2 node 81

HSAE2 node 83

Table 2462 - Proteins of interest

These sequences are variants of the known protein Anion exchange protein 2 (SwissProt accession identifier B3A2_HUMAN; known also according to the synonyms Non-erythroid band 3- like protein; BND3L), referred to herein as the previously known protein.

Protein Anion exchange protein 2 is known or believed to have the following function(s): Plasma membrane anion exchange protein of wide distribution. The sequence for protein Anion exchange protein 2 is given at the end of the application, as "Anion exchange protein 2 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2463.

Table 2463 - Amino acid mutations for Knowrt Protein

Protein Anion exchange protein 2 localization is believed to be Integral membrane protein.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: anion transport, which are annotation(s) related to Biological Process; inorganic anion exchanger; anion transporter; antiporter, which are annotation(s) related to Molecular Function; and membrane fraction; membrane; integral membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HSAE2 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 66 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following ©suits were obtained as shown with regard to the histograms in Figure 66 and Table 2464. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, a mixture of malignant tumors from lifferent-tissues-and-prostate-cancer,- — ■ - — — ~ —

Table 2464 - Normal tissue distribution

Table 2465 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSAE2 features 58 segment(s), which were listed in Table 2461 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster HSAE2_node_0 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T8, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2466 below describes the starting and ending position of this segment on each transcript.

Table 2466 - Segment location on transcripts

JTiiis_segmentj:ari be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAE2_P5, HSAE2_P7, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15, HSAE2J?26, HSAE2_P37 and HSAE2_P38.

Segment cluster HSAE2_node_2 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T4. Table 2467 below describes the starting and ending position of this segment on each transcript.

Table 2467 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAE2_P41. Segment cluster HSAE2_node_9 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1. Table 2468 below describes the starting and ending position of this segment on each transcript.

Table 2468 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2JP2.

Segment cluster HSAE2_node_12 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T7. Table 2469 below describes the starting and ending position of this segment on each transcript.

Table 2469 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAE2_P3.

Segment cluster HSAE2_node_13 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2470 below describes the starting and ending position of this segment on each transcript. Table 2470 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2JP3, HSAE2JP5, HSAE2JP7 and HSAE2_P38. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2JP41, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15, HSAE2_P26 and HSAE2_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_14 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T8. Table 2471 below describes the starting and ending position of this segment on each transcript.

Table 2471 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P5.

Segment cluster HSAE2_node_17 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2472 below describes the starting and ending position of this segment on each transcript.

Table 2472 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as -iQlIαws > Jhe_segment.can_be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): HSAE2_P3, HSAE2_P7 and HSAE2_P38. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2 JP41, HSAE2_P5, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2 P15, HSAE2_P26 and HSAE2_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_22 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T10. Table 2473 below describes the starting and ending position of this segment on each transcript.

Table 2473 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P3.

Segment cluster HSAE2_node_23 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2__T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2474 below describes the starting and ending position of this segment on each transcript.

Table 2474 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P7. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P13, HSAE2_P18, HSAE2JP23, HSAE2_P15, HSAE2_P26, HSAE2_P37 and HSAE2_P38, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_26 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2475 below describes the starting and ending position of this segment on each transcript.

Table 2475 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAE2_P7. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15, HSAE2_P26, HSAE2_P37 and HSAE2_P38, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_28 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2476 below describes the starting and ending position of this segment on each transcript. Table 2476 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAE2_P7. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_P13, HBAE2JP18, HSAE2_P23, HSAE2_P15, HSAE2_P26, HSAE2_P37 and HSAE2_P38, since it is in the coding region for ^"the corresponding transcript. ^{' ~~ ~ ~~ ~ ~ ~~~ ~~ ~~~}

Segment cluster HSAE2_node_29 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T47 and HSAE2_T48. Table 2477 below describes the starting and ending position of this segment on each transcript.

Table 2477 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P37 and HSAE2_P38. Segment cluster HSAE2_node_34 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2478 below describes the starting and ending position of this segment on each transcript.

Table 2478 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P7. This segment can also be found in the following protein(s):

HSAE2_P2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_JP13, HSAE2_P18, HSAE2_P23,

HSAE2JP15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_36 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2479 below describes the starting and ending position of this segment on each transcript.

Table 2479 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P7. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_P13, HSAE2_P18, HSAE2_P23,

HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

_Segment_cluster HSAE2jαode_42 according to the present -invention is_supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T11 and HSAE2_T18. Table 2480 below describes the starting and ending position of this segment on each transcript.

Table 2480 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P7 and HSAE2_P13.

Segment cluster HSAE2_node_43 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2481 below describes the starting and ending position of this segment on each transcript.

Table 2481 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s):

ΪS^"AE2_:P2ΓHSAE2IP417ΗSAE2IP3ΓHSAE2^~P5ΓHSAE2-P7-HSΑE2-P18ΓHSAE2IP23Γ HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_54 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the Mowing transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2 T32 and HSAE2_T34. Table 2482 below describes the starting and ending position of this segment on each transcript.

Table 2482 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s): HSAE2JP2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2JP23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2__node_59 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2483 below describes the starting and ending position of this segment on each transcript.

Table 2483 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2JP3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2_P23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_64 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2484 below describes the starting and ending position of this segment on each transcript.

Table 2484 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2JP13. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2JP5, HSAE2_P7, HSAE2_P18, HSAE2_P23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript. Segment cluster HSAE2_node_71 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T23 and HSAE2_T32. Table 2485 below describes the starting and ending position of this segment on each transcript.

Table 2485 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2JP15. This segment can also be found in the following protein(s): 10 HSAE2_P18, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_72 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be ■ — — found in the following transcript(s): HSAE2-^r23-and-HSAE2-T32.-T-able-2486-below-describes- 15 the starting and ending position of this segment on each transcript.

Table 2486 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2JP18 and HSAE2JP15.

20

Segment cluster HSAE2_node_73 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2487 below describes the starting and ending position of this segment on each transcript.

Table 2487 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13, HSAE2_P18 and HSAE2_P15. This segment can also be foϋffii^~m^~thir-followingHpiOte^ HSAE2_P7, HSAE2_P23 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_74 according to the present invention is supported by 130 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2488 below describes the starting and ending position of this segment on each transcript.

Table 2488 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2JP13, HSAE2_P18 and HSAE2_P15. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P23 and HSAE2JP26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_76 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be

HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2JB2 and HSAE2_T34. Table 2489 below describes the starting and ending position of this segment on each transcript. Table 2489 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13, HSAE2_P18 and HSAE2_P15. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P23 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_77 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T29 and HSAE2_T34. Table 2490 below describes the starting and ending position of this segment on each transcript.

Table 2490 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P23 and HSAE2_P26.

Segment cluster HSAE2_node_82 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2491 below describes the starting and ending position of this segment on each transcript.

Table 2491 - Segment location on transcripts

This segment can be found in both coding and non-coding legions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13, HSAE2_P18 and HSAE2JP15. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P23 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSAE2_node_6 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T4, HSAE2_T8, HSAE2_T11, HSAE2_T18,

HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table

2492 below describes the starting and ending position of this segment on each transcript.

Table 2492 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2JP5, HSAE2_P7 and HSAE2_P38. This segment can also be found in the following protein(s): HSAE2_P41, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15, HSAE2JP26 and HSAE2_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_8 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1. Table 2493 below describes the starting and ending position of this segment on each transcript.

Table 2493 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P2.

Segment cluster HSAE2_node_l 1 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T7. Table 2494 below describes the starting and ending position of this segment on each transcript.

Table 2494 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2__P3.

Segment cluster HSAE2_node_15 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2495 below describes the starting and ending position of this segment on each transcript.

Table 2495 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P3, HSAE2_P7 and HSAE2_P38. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2JP41, HSAE2_P5, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15, HSAE2JP26 and HSAE2_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_16 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T1 1, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2496 below describes the starting and ending position of this segment on each transcript.

Table 2496 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as jbllows.JQie_segment can_beJbmidJrL.ajiθJtcαd^gJcegiorLθJLtranscripi(s)Jhat_are. related, to the_ following protein(s): HSAE2_P3, HSAE2_P7 and HSAE2_P38. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P5, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15, HSAE2_P26 and HSAE2_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_l 8 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T48. Table 2497 below describes the starting and ending position of this segment on each transcript.

Table 2497 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P38.

Segment cluster HSAE2_node_l 9 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2498 below describes the starting and ending position of this segment on each transcript.

Table 2498 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P3 and HSAE2_P7. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2J^>5, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2JP15, HSAE2_P26, HSAE2_P37 and HSAE2_P38, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_20 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8,

HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2 T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2499 below describes the starting and ending position of this segment on each transcript.

Table 2499 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): ΗSAE2_P 3 and HSAE2_P7. This segment can aIso be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P5, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15, HSAE2_P26, HSAE2_P37 and HSAE2_P38, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_24 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32, HSAE2_T34, HSAE2_T47 and HSAE2_T48. Table 2500 below describes the starting and ending position of this segment on each transcript.

Table 2500 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2JP7. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2J^»13, HSAE2_P18, HSAE2_P23, HSAE2_P15, HSAE2JP26, HSAE2_P37 and HSAE2JP38, since it is in the coding region for the corresponding transcript.

— Segment-cluster JHS AE2_z;node_:;r38 -according-to-the-present_inv-ention_is_supported-by_45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2501 below describes the starting and ending position of this segment on each transcript.

Table 2501 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P13, HSAE2_P18, HSAE2JP23, HSAE2_P15 and HSAE2_P26.

Segment cluster HSAE2_node_40 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2JN, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2502 below describes the starting and ending position of this segment on each transcript.

Table 2502 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2JP5, HSAE2_P7, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15 and HSAE2 P26.

Segment cluster HSAE2_node_41 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2503 below describes the starting and ending position of this segment on each transcript.

Table 2503 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P13, HSAE2_P18, HSAE2_P23, HSAE2_P15

-andΗS-AΕ2-P26-T

Segment cluster HSAE2_node_44 according to the present invention can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2JN0, HSAE2JN 1, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2504 below describes the starting and ending position of this segment on each transcript.

Table 2504 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2JP13. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2_P23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_45 according to the present invention can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2505 below describes the starting and ending position of this segment on each transcript.

Table 2505 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2JP18, HSAE2_P23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript. Segment cluster HSAE2__node_46 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2506 below describes the starting and ending position of this segment on each transcript.

Table 2506 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s):

HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2_P23,

HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_48 according to the present invention can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2507 below describes the starting and ending position of this segment on each transcript.

Table 2507 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2_P23, HSAE2_P15 and HSAE2 P26.

Segment cluster HSAE2_node_49 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2508 below describes the starting and ending position of this segment on each transcript.

Table 2508 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2JP7, HSAE2_P18, HSAE2JP23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_50 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2509 below describes the starting and ending position of this segment on each transcript.

Table 2509 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s):

HSAE2_P2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2_P23,

HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_51 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2510 below describes the starting and ending position of this segment on each transcript.

Table 2510 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : HSAΕ2_P13. This segment can also be found in the following protein(s) :

HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2_P23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_56 according to the present invention can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2511 below describes the starting and ending position of this segment on each transcript.

Table 2511 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2_P23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_57 according to the present invention can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2512 below describes the starting and ending position of this segment on each transcript.

Table 2512 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2_P23, HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_58 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2513 below describes the starting and ending position of this segment on each transcript.

Table 2513 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2JP18, HSAE2_P23,

HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_65 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8,

HSAE2_T10, HSAE2JN1, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2514 below describes the starting and ending position of this segment on each transcript.

Table 2514 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13. This segment can also be found in the following protein(s): ΗSAE2_P2, ΗSΑE2_P41, HSΑE2_P3 , ΗSAE2_P5, HSΑE2_P7, HSAE2_P18, HSAE2_P23,

HSAE2_P15 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_66 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HSAE2_T32. Table 2515 below describes the starting and ending position of this segment on each transcript.

Table 2515 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P15. Segment cluster HSAE2_node_67 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2516 below describes the starting and ending position of this segment on each transcript.

Table 2516 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAE2_P13 and HSAE2_P15. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P18, HSAE2JP23 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_69 according to the present invention is supported by 118 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2517 below describes the starting and ending position of this segment on each transcript. Table 2517 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13 and HSAE2_P15. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2JP18, HSAE2_P23 and HSAE2_P26, since it is in the coding region for the ^oTτFspOnding^~tranSCript7 ^{" ~"}~ ^{~ ' ~~} ~ ^{~ ~ ~}

Segment cluster HSAE2_node_70 according to the present invention is supported by 115 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2JN, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2518 below describes the starting and ending position of this segment on each transcript.

Table 2518 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13 and HSAE2_P15. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2JP18, HSAE2_P23 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_78 according to the present invention is supported by 137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8,

HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2 T34. Table 2519 below describes the starting and ending position of this segment on each transcript. Table 2519 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13, HSAE2_P18 and HSAE2_P15. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P23 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node__79 according to the present invention can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2520 below describes the starting and ending position of this segment on each transcript.

Table 2520 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13, HSAE2_P18 and HSAE2_P15. This segment can also be found in the following protein(s): HSAE2JP2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P23 and HSAE2_P26, since it is in the coding region for the corresponding transcript. Segment cluster HSAE2_node_80 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2521 below describes the starting and ending position of this segment on each transcript.

Table 2521 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P13, HSAE2JP18 and HSAE2_P15. This segment can also be found in the following protein(s): HSAE2_P2, HSAE2JP41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P23 and HSAE2_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HSAE2_node_81 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2_T34. Table 2522 below describes the starting and ending position of this segment on each transcript. Table 2522 - Segment location on transcripts

This segment can be found in the following protein(s): HSAE2_P26.

Segment cluster HSAE2_node_83 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAE2 _T1, HSAE2_T4, HSAE2_T7, HSAE2_T8, HSAE2_T10, HSAE2_T11, HSAE2_T18, HSAE2_T23, HSAE2_T29, HSAE2_T32 and HSAE2_T34. Table 2523 below describes the starting and ending position of this segment on each transcript.

Table 2523 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAE2_P2, HSAE2_P41, HSAE2_P3, HSAE2_P5, HSAE2_P7, HSAE2_P13, HSAE2 P18, HSAE2_P23, HSAE2_P15 and HSAE2_P26.

DESCRIPTION FOR CLUSTER HSAPHOL Cluster HSAPHOL features 3 transcript(s) and 20 segment(s) of interest, the names for which are given in Tables 2524 and 2525, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2526.

Table 2524 - Transcripts of interest

Transcript Name

HSAPHOL T2

HSAPHOL T3

HSAPHOL T12

Table 2525 - Segments of interest

Segment Name

HSAPHOL node 0

HSAPHOL node 2

HSAPHOL node 6

HSAPHOL node 11

HSAPHOL node 13

HSAPHOL node 19

HSAPHOL node 21

HSAPHOL node 23

HSAPHOL node 28_

HSAPHOL node 32

HSAPHOL node 38

HSAPHOL node 40

HSAPHOL node 42

HSAPHOL node 16

HSAPHOL node 25

HSAPHOL node 33

HSAPHOL node 34

HSAPHOL node 35

HSAPHOL node 36

HSAPHOL node 41

Table 2526 - Proteins of interest

These sequences are variants of the known protein Alkaline phosphatase, tissue- nonspecific isozyme precursor (SwissProt accession identifier PPBT_HUMAN; known also according to the synonyms EC 3.1.3.1; AP-TNAP; Liver/bone/kidney isozyme; TNSALP), referred to herein as the previously known protein.

Protein Alkaline phosphatase, tissue -nonspecific isozyme precursor is known or believed to have the following function(s): THIS ISOZYME MAY PLAY A ROLE IN SKELETAL MINERALIZATION. The sequence for protein Alkaline phosphatase, tissue-nonspecific isozyme precursor is given at the end of the application, as "Alkaline phosphatase, tissue- nonspecific isozyme precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2527.

Table 2527 - Amino acid mutations for Known Protein

Protein Alkaline phosphatase, tissue-nonspecific isozyme precursor localization is believed to be Attached to the membrane by a GPI- anchor. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: skeletal development; ossification; metabolism, which are annotation(s) related to Biological Process; magnesium binding; alkaline phosphatase; hydrolase, which are annotation(s) related to Molecular Function; and integral membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.cb/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 2528.

TάBle^~2J28^{" ~}Olιgonucleotϊ3esl-elafed^'to^'tKis cluster ^{~ " ~ ~~ ~ "}

As noted above, cluster HSAPHOL features 20 segment(s), which were listed in Table 2525 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSAPHOL_node_0 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL T3. Table 2529 below describes the starting and ending position of this segment on each transcript.

Table 2529 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAPHOL_P1.

Segment cluster HSAPHOL_node_2 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2. Table 2530 below describes the starting and ending position of this segment on each transcript.

Table 2530 - Segment location on transcripts

Transcript name Segment Segment starting position ending position

HSAPHOL T2 1 ^"148^"

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAPHOL_P1.

Segment cluster HSAPHOL_node_6 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2. Table 2531 below describes the starting and ending position of this segment on each transcript.

Table 2531 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAPHOLJP1. Segment cluster HSAPHOL_node_l 1 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2 and HSAPHOL_T3. Table 2532 below describes the starting and ending position of this segment on each transcript.

Table 2532 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOL Pl.

Segment cluster HSAPHOL_node_13 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2 and HSAPHOL_T3. Table 2533 below describes the starting and ending position of this segment on each transcript.

^~Tabl(T2533^~Segment location on transcripts — — — — — -

This segment can be found in the following protein(s): HSAPHOL_P1.

Segment cluster HSAPHOL_node_19 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2 and HSAPHOL_T3. Table 2534 below describes the starting and ending position of this segment on each transcript.

Table 2534 - Segment location on transcripts

HSAPHOL T3 589 763

This segment can be found in the following protein(s): HSAPHOLJP 1.

Segment cluster HSAPHOL_node_21 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2 and HSAPHOL_T3. Table 2535 below describes the starting and ending position of this segment on each transcript.

Table 2535 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOL Pl.

Segment cluster HSAPHOL_node_23 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found In the following transcript(s): HSAPHOL_T2^"and HSAPHOL_T3. Table 2536 below describes the starting and ending position of this segment on each transcript.

Table 2536 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOL_P1.

Segment cluster HSAPHOL_node_28 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2 and HSAPHOL_T3. Table 2537 below describes the starting and ending position of this segment on each transcript.

Table 2537 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOLJ? 1.

Segment cluster HSAPHOL_node_32 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL T12. Table 2538 below describes the starting and ending position of this segment on each transcript.

Table 2538 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAPHOL P9.

Segment cluster HSAPHOL_node_38 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2, HSAPHOL_T3 and HSAPHOL_T12. Table 2539 below describes the starting ard ending position of this segment on each transcript.

Table 2539 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOL Pl and HSAPHOL P9. Segment cluster HSAPHOL_node_40 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2, HSAPHOL_T3 and HSAPHOL_T12. Table 2540 below describes the starting and ending position of this segment on each transcript.

Table 2540 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOL Pl and HSAPHOLJP9.

Segment cluster HSAPHOL_node_42 according to the present invention is supported by

99 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2, HSAPHOL_T3 and HSAPHOL_T12. Table 2541 below describes the starting and ending position of this segment on each transcript.

Table 2541 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAPHOLJP1 and HSAPHOL_P9.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster HSAPHOL_node_16 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2 and HSAPHOL_T3. Table 2542 below describes the starting and ending position of this segment on each transcript.

Table 2542 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOLJP 1.

Segment cluster HSAPHOL node 25 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2 and HSAPHOL T3. Table 2543 below describes the starting and ending position of this segment on each transcript.

Table 2543 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOLJ³I.

Segment cluster HSAPHOL_node_33 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T12. Table 2544 below describes the starting and ending position of this segment on each transcript.

Table 2544 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSAPHOL_P9.

Segment cluster HSAPHOL_node_34 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2, HSAPHOLJB and HSAPHOL T12. Table 2545 below describes the starting and ending position of this segment on each transcript.

Table 2545 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOL Pl and

HSAPHOL P9.

Segment cluster HSAPHOL_node_35 according to the present invention is supported by

51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL T2, HSAPHOL_T3 and HSAPHOL_T12. Table 2546 below describes the starting and ending position of this segment on each transcript.

Table 2546 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOL_P1 and HSAPHOL P9.

Segment cluster HSAPHOL_node_36 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL T2, HSAPHOL T3 and HSAPHOL_T12. Table 2547 below descπbes the starting and ending position of this segment on each transcript.

Table 2547 - Segment location on transcripts

This segment can be found in the following protein(s): HSAPHOL Pl and HSAPHOL P9.

Segment cluster HSAPHOL_node_41 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSAPHOL_T2, HSAPHOL_T3 and HSAPHOL T12. Table 2548 below describes the starting and ending position of this segment on each transcript.

Table 2548 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSAPHOL_P1 and HSAPHOL_P9.

DESCRIPTION FOR CLUSTER HSCDC2

Cluster HSCDC2 features 8 transcript(s) and 20 segment(s) of interest, the names for which are given in Tables 1 and 2, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2551.

Table 2549 - Transcripts of interest Transcript Name

HSCDC2 TO

HSCDC2 Tl

HSCDC2 T4

HSCDC2 T5

HSCDC2 T9

HSCDC2 TlO

HSCDC2 TI l

HSCDC2 T14

Table 2550 - Segments of interest

Segment Name

HSCDC2 node 6

HSCDC2 node 8

HSCDC2 node 16

HSCDC2 node 18

HSCDC2 node 20

HSCDC2 node 23

HSCDC2 node 25

HSCDC2 node 27

HSCDC2 node 0

HSCDC2 node 1

HSCDC2 node 2

HSCDC2 node 4

HSCDC2 node 10

HSCDC2 node 12

HSCDC2 node 13

HSCDC2 node 14

HSCDC2 node 21

HSCDC2 node 22

HSCDC2 node 24

HSCDC2 node 26

Table 2551 - Proteins of interest

These sequences are variants of the known protein Cell division control protein 2 homolog (SwissProt accession identifier CDC2JHUMAN; known also according to the synonyms EC 2.7.1.-; p34 protein kinase; Cyclin- dependent kinase 1; CDKl), referred to herein as the previously known protein. Protein Cell division control protein 2 homolog is known or believed to have the following function(s): Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive carboxyl-terminus of RNA polymerase II. The sequence for protein Cell division control protein 2 homolog is given at the end of the application, as "Cell division control protein 2 homolog amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2552.

Table 2552 - Amino acid mutations for Known Protein

Protein Cell division control protein 2 homolog localization is believed to be Nuclear (By

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein amino acid phosphorylation; mitosis; start control point of mitotic cell cycle, which are annotation(s) related to Biological Process; cyclin-dependent protein kinase; ATP binding; transferase, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>. Cluster HSCDC2 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in noπnal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 67 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 67 and Table 2553. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues and breast malignant tumors.

Table 2553 - Normal tissue distribution

Table 2554 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 2555.

Table 2555 - Oligonucleotides related to this cluster

As noted above, cluster HSCDC2 features 20 segment(s), which were listed in Table 2550 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSCDC2_node_6 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the βllowing transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2 T10 and HSCDC2 T 11. Table 2556 below describes the starting and ending .position_. of this segment on each transcript. Table 2556 - Segment location on transcripts

This segment can be found in the following protein(s): HSCDC2_P1, HSCDC2_P4 and HSCDC2 P5.

Segment cluster HSCDC2_node_8 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC 2_T5, HSCDC2_T9, HSCDC2_T10 and HSCDC2_T11. Table 2557 below describes the starting and ending position of this segment on each transcript.

Table 2557 - Segment location on transcripts

This segment can be found in the following protein(s): HSCDC2_P1, HSCDC2_P3, HSCDC2 P4 and HSCDC2 P5.

Segment cluster HSCDC2_node_16 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2 T10 and HSCDC2_T11. Table 2558 below describes the starting and ending position of this segment on each transcript.

Table 2558 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P4. This segment can also be found in the following protein(s): HSCDC2JP1, HSCDC2_P3 and HSCDC2JP5, since it is in the coding region for the corresponding transcript.

Segment cluster HSCDC2_node_l 8 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10 and HSCDC2_T11. Table 2559 below describes the starting and ending position of this segment on each transcript.

Table 2559 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcriρt(s) that are related to the following protein(s): HSCDC2_P4. This segment can also be found in the following protein(s):

HSCDC2_P1, HSCDC2JP3 and HSCDC2_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HSCDC2_node_20 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T14. Table 2560 below describes the starting and ending position of this segment on each transcript.

Table 2560 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSCDC2__node_23 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2 T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10, HSCDC2_T11 and HSCDC2_T14. Table 2561 below describes the starting and ending position of this segment on each transcript.

Table 2561 - Segment location on transcripts

-10-

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P1, HSCDC2_P3, HSCDC2_P4 and HSCDC2_P5.

Segment cluster HSCDC2_node_25 according to the present invention is supported by 71

15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5,

HSCDC2_T9, HSCDC2_T10, HSCDC2_T11 and HSCDC2_T14. Table 2562 below describes the starting and ending position of this segment on each transcript.

Table 2562 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2JP1, HSCDC2JP3, HSCDC2_P4 and HSCDC2_P5.

Segment cluster HSCDC2_node_27 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10, HSCDC2_T11 and HSCDC2_T14. Table 2563 below describes the starting and ending position of this segment on each transcript. Table 2563 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P1, HSCDC2JP3, HSCDC2_P4 and HSCDC2_P5.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSCDC2 node_0 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10 and HSCDC2_T11. Table 2564 below describes the starting and ending position of this segment on each transcript.

Table 2564 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P1, HSCDC2_P3, HSCDC2_P4 and HSCDC2_P5.

Segment cluster HSCDC2_node_l according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T9, HSCDC2_T10 and HSCDC2_T11. Table 2565 below describes the starting and ending position of this segment on each transcript.

Table 2565 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2JP1, HSCDC2_P3, HSCDC2_P4 and HSCDC2_P5. Segment cluster HSCDC2_node_2 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T4 and HSCDC2_T9. Table 2566 below describes the starting and ending position of this segment on each transcript.

Table 2566 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSCDC2_P1 and HSCDC2_P3.

Segment cluster HSCDC2_node_4 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2 T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10 and HSCDC2_T11. Table 2567 below describes the starting and -ending-position-of-this-segment-on-eaGh-transeripfe — — ■ — Table 2567 - Segment location on transcripts

This S3gment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P3. This segment can also be found in the following protein(s): HSCDC2JP1, HSCDC2_P4 and HSCDC2_P5, since it is in the coding region for the corresponding transcript. Segment cluster HSCDC2_node_l 0 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T10. Table 2568 below describes the starting and ending position of this segment on each transcript.

Table 2568 - Segment location on transcripts

This segment can be found in the following protein(s): HSCDC2_P4.

Segment cluster HSCDC2_node_12 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9 and HSCDC2_T10. Table 2569 below describes the starting and ending position of this segment on each transcript. Table 2569 - Segment location on transcripts

This segment can be found in the following protein(s): HSCDC2_P1, HSCDC2_P3 and HSCDC2 P4.

Segment cluster HSCDC2_node_13 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9 and HSCDC2_T10. Table 2570 below describes the starting and ending position of this segment on each transcript.

Table 2570 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P4. This segment can also be found in the following protein(s): HSCDC2_P1 and HSCDC2 P3, since it is in the coding region for the corresponding transcript.

Segment cluster HSCDC2_node_14 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be_ found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9 and HSCDC2_T10. Table 2571 below describes the starting and ending position of this segment on each transcript. Table 2571 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P4. This segment can also be found in the following protein(s): HSCDC2 P1 and HSCDC2_P3, since it is in the coding region for the corresponding transcript.

Segment cluster HSCDC2_node_21 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10, HSCDC2_T11 and HSCDC2_T14. Table 2572 below describes the starting and ending position of this segment on each transcript.

Table 2572 - Segment location on transcripts

Transcript name Segment Segment starting position ending position

HSCDC2 TO 1050 1152

HSCDC2 Tl 1050 1152

HSCDC2 T4 1148 1250

HSCDC2 T5 939 1041

HSCDC2 T9 991 1093

HSCDC2 TlO 1084 1186

HSCDC2 TIl 879 981

HSCDC2 T14 1403 1505

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P4. This segment can also be found in the following protein(s): HSCDC2_P1, HSCDC2_P3 and HSCDC2_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HSCDC2_node_22 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10, HSCDC2_T11 and HSCDC2_T14. Table 2573 below describes the starting and ending position of this segment on each transcript.

Table 2573 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P1, HSCDC2_P3, HSCDC2_P4 and HSCDC2_P5.

Segment cluster HSCDC2_node_24 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10, HSCDC2_T11 and HSCDC2_T14. Table 2574 below describes the starting and ending position of this segment on each transcript.

-Tabte^57^~4^~SegmenrlocatiOn-σrr1rωτsvrψts — — —

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2_P1, HSCDC2_P3, HSCDC2_P4 and HSCDC2_P5.

Segment cluster HSCDC2_node_26 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCDC2_T0, HSCDC2_T1, HSCDC2_T4, HSCDC2_T5, HSCDC2_T9, HSCDC2_T10, HSCDC2_T11 and HSCDC2_T14. Table 2575 below describes the starting and ending position of this segment on each transcript.

Table 2575 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCDC2JP1, HSCDC2_P3, HSCDC2 P4 and HSCDC2_P5.

DESCRIPTION FOR CLUSTER HSCYTK

Cluster HSCYTK features 3 transcript(s) and 45 segment(s) of interest, the names for which are given in Tables 2576 and 2577, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2578.

Table 2576 - Transcripts of interest

Transcript Name

HSCYTK T2

HSCYTK TIl

HSCYTK T30

Table 2577 - Segments of interest

Segment Name

HSCYTK node 0

HSCYTK node 21 HSCYTK node 39

HSCYTK node 44

HSCYTK node 53

HSCYTK node 1

HSCYTK node 2

HSCYTK node 3

HSCYTK node 4

HSCYTK node 5

HSCYTK node 6

HSCYTK node 7

HSCYTK node 8

HSCYTK node 9

HSCYTK node 10

HSCYTK node 11

HSCYTK node 12

HSCYTK node 13

HSCYTK node 15

HSCYTK node 16

HSCYTK node 18

HSCYTK node 19

HSCYTK node 20

HSCYTK node 22

HSCYTK node 23

HSCYTK node 24.

HSCYTK node 25

HSCYTK node 27

HSCYTK node 28

HSCYTK node 29

HSCYTK node 31

HSCYTK node 32

HSCYTK node 33

HSCYTK node 34

HSCYTK node 35

HSCYTK node 36

HSCYTK node 41

HSCYTK node 45

HSCYTK node 46

HSCYTK node 47

HSCYTK node 48

HSCYTK node 49

HSCYTK node 50

HSCYTK node 51

HSCYTK node 52 Table 2578 - Proteins of interest

These sequences are variants of the known protein Keratin, type I cytoskeletal 13 (SwissProt accession identifier K ICMJHUMAN; known also according to the synonyms Cytokeratin 13; K13; CK 13), referred to herein as the previously known protein.

The sequence for protein Keratin, type I cytoskeletal 13 is given at the end of the application, as "Keratin, type I cytoskeletal 13 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2579.

Table 2579 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: epidermal differentiation, which are annotation(s) related to Biological Process; structural protein of cytoskeleton, which are annotation(s) related to Molecular Function; and intermediate filament, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>. Cluster HSCYTK can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 68 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 68 and Table 2580. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: a mixture of malignant tumors from different tissues.

Table 2580 - Normal tissue distribution

Table 2581 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 2582.

Table 2582 - Oligonucleotides related to this cluster

As noted above, cluster HSCYTK features 45 segment(s), which were listed in Table 2577 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSCYTK_node_0 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2583 below describes the starting and ending position of this segment on each transcript. Table 2583 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK__node_21 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_Tl l. Table 2584 below describes the starting and ending position of this segment on each transcript.

Table 2584 - Segment location on transcripts

^"This segment can be found 5fthe following proternXsjrΗSCYTKJTO.

Segment cluster HSCYTK_node_39 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T30. Table 2585 below describes the starting and ending position of this segment on each transcript.

Table 2585 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSCYTK_node_44 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2. Table 2586 below describes the starting and ending position of this segment on each transcript.

Table 2586 - Segment location on transcripts

This segment can be found in the following protein(s): H8CYTKJP2.

Segment cluster HSCYTK_node_53 according to the present invention is supported by 89 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2, HSCYTK_Tl 1 and HSCYTK_T30. Table 2587 below describes the starting and ending position of this segment on each transcript.

Table 2587 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTK_P2 and HSCYTKJP10.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSCYTK_node_l according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK T2 and HSCYTK_T11. Table 2588 below describes the starting and ending position of this segment on each transcript. Table 2588 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_2 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2589 below describes the starting and ending position of this segment on each transcript.

Table 2589 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_3 according to the present invention can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_T11. Table 2590 below describes the starting and ending position of this segment on each transcript.

Table 2590 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_4 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK _T2 and HSCYTK_Tl 1. Table 2591 below describes the starting and ending position of this segment on each transcript.

Table 2591 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTKJP 10.

Segment cluster HSCYTK_node_5 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2592 below describes the starting and ending position of this segment on each transcript.

Table 2592 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTKJP2 and HSCYTKJP10.

Segment cluster HSCYTK node ό according to the present invention can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2593 below describes the starting and ending position of this segment on each transcript.

Table 2593 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10. Segment cluster HSCYTK_node_7 according to the present invention can be found in the following transcript(s): HSCYTK_T2 and HSCYTK-Tl 1. Table 2594 below describes the starting and ending position of this segment on each transcript.

Table 2594 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTKJP2 and HSCYTK_P10.

Segment cluster HSCYTK_node_8 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl l . Table 2595 below describes the starting and ending position of this segment on each transcript.

Table 2595 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_9 according to the present invention can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_T11. Table 2596 below describes the starting and ending position of this segment on each transcript.

Table 2596 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTKJP2 and HSCYTK_P10. Segment cluster HSCYTK_node_10 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK JI l . Table 2597 below describes the starting and ending position of this segment on each transcript.

Table 2597 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_l 1 according to the present invention is supported ^"by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl l. Table 2598 below describes the starting and ending position of this segment on each transcript.

Table 2598 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTKJP2 and H8CYTKJP10.

Segment cluster HSCYTK_node_12 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK-Tl 1. Table 2599 below describes the starting and ending position of this segment on each transcript.

Table 2599 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_13 according to the present invention is supported by 69 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2600 below describes the starting and ending position of this segment on each transcript.

Table 2600 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_l 5 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK-TI l. Table 2601 below describes the starting and ending position of this segment on each transcript.

Table 2601 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_16 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK-Tl 1. Table 2602 below describes the starting and ending position of this segment on each transcript.

Table 2602 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTKJP 10.

Segment cluster HSCYTK_node_l 8 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2603 below describes the starting and ending position of this segment on each transcript.

Table 2603 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTKJP10.

Segment cluster HSCYTK_node_19 according to the present invention is supported by 75 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2604 below describes the starting and ending position of this segment on each transcript.

Table 2604 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_20 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2605 below describes the starting and ending position of this segment on each transcript.

Table 2605 - Segment location on transcripts

This segment can be found in the following protein(s): H3CYTKJP2 and HSCYTK_P10.

Segment cluster HSCYTK_node_22 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK-Tl 1. Table 2606 below describes the starting and ending position of this segment on each transcript.

Table 2606 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_23 according to the present invention can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl l. Table 2607 below describes the starting and ending position of this segment on each transcript.

Table 2607 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10. Segment cluster HSCYTK_node_24 according to the present invention can be found in the following transcript(s): HSCYTK T2 and HSCYTK_Tl l. Table 2608 below describes the starting and ending position of this segment on each transcript.

Table 2608 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTKJP10.

Segment cluster HSCYTK_node__25 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK-Tl 1. Table 2609 below describes the starting and ending position of this segment on each transcript.

Table 2609 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTKJP2 and HSCYTK_P10.

Segment cluster HSCYTK_node_27 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2610 below describes the starting and ending position of this segment on each transcript.

Table 2610 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTKJP2 and HSCYTK_P10. Segment cluster HSCYTK_node_28 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2611 below describes the starting and ending position of this segment on each transcript.

Table 2611 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK P 10.

Segment cluster HSCYTK_node_29 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK T2 and HSCYTK_T11. Table 2612 below describes the starting and ending position of this segment on each transcript.

Table 26^~12^~Segmeni location όiTirahscfipts ^{~ ~~}

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTKJP10.

Segment cluster HSCYTK_node_31 according to the present invention can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2613 below describes the starting and ending position of this segment on each transcript.

Table 2613 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTKJP 10.

Segment cluster HSCYTK_node_32 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_T11. Table 2614 below describes the starting and ending position of this segment on each transcript.

Table 2614 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTKJPl 0.

Segment cluster HSCYTK_node_33 according to the present invention can be found in the following transcript(s): HSCYTK_T2 and HSCYTK TIl. Table 2615 below describes the starting and ending position of this segment on each transcript. Table 2615 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTKJP2 and HSCYTK_P10.

Segment cluster HSCYTK_node_34 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_Tl 1. Table 2616 below describes the starting and ending position of this segment on each transcript.

Table 2616 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTKJP2 and HSCYTK_P10.

Segment cluster HSCYTK_node_35 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK_T11. Table 2617 below describes the starting and ending position of this segment on each transcript.

Table 2617 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTKJP 10.

Segment cluster HSCYTK_node_36 according to the present invention is supported by 99 -librariesr The-number- of-libraries was-determined-as previously-described— This-segment-can-be found in the following transcript(s): HSCYTK_T2 and HSCYTK_T11. Table 2618 below describes the starting and ending position of this segment on each transcript.

Table 2618 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_41 according to the present invention is supported by

100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2 and HSCYTK-Tl 1. Table 2619 below describes the starting and ending position of this segment on each transcript. Table 2619 - Segment location on transcripts

This segment can be found in the following protein(s): HSCYTK_P2 and HSCYTK_P10.

Segment cluster HSCYTK_node_45 according to the present invention can be found in the following transcript(s): HSCYTK_T2, HSCYTK_Tl 1 and HSCYTK_T30. Table 2620 below describes the starting and ending position of this segment on each transcript.

Table 2620 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTK_P2. This segment can also be found in the following protein(s): HSCYTKJP 10, since it is in the coding region for the corresponding transcript.

Segment cluster HSCYTK_node_46 according to the present invention can be found in the following transcript(s): HSCYTK_T2, HSCYTK_Tl 1 and HSCYTK_T30. Table 2621 below describes the starting and ending position of this segment on each transcript.

Table 2621 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTK_P2. This segment can also be found in the ibllowing protein(s): HSCYTKJP 10, since it is in the coding region for the corresponding transcript.

Segment cluster HSCYTK_node_47 according to the present invention can be found in the following transcript(s): HSCYTK J2, HSCYTK_Tl l and HSCYTK_T30. Table 2622 below describes the starting and ending position of this segment on each transcript.

Table 2622 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTK P2. This segment can also be found in the following protein(s):

HSCYTK_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HSCYTK_node_48 according to the present invention can be found in the following transcript(s): HSCYTK_T2, HSCYTK_Tl l and HSCYTK_T30. Table 2623 below describes the starting and ending position of this segment on each transcript.

Table 2623 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTK_P2. This segment can also be found in the following protein(s): HSCYTKJP 10, since it is in the coding region for the corresponding transcript.

Segment cluster HSCYTK_node_49 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2, HSCYTK_Tl 1 and HSCYTK_T30. Table 2624 below describes the starting and ending position of this segment on each transcript.

Table 2624 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTKJP2. This segment can also be found in the following protein(s): HSCYTKJP 10, since it is in the coding region for the corresponding transcript.

Segment cluster HSCYTK_node_50 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2, HSCYTK_Tl 1 and HSCYTK_T30. Table 2625 below describes the starting and ending position of this segment on each transcript.

Table 2625 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTK_P2 and HSCYTK_P10. Segment cluster HSCYTK_node_51 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2, HSCYTK_Tl 1 and HSCYTK_T30. Table 2626 below describes the starting and ending position of this segment on each transcript.

Table 2626 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTKJP2 and HSCYTKjP 10.

Segment cluster HSCYTK_node_52 according to the present invention is supported by 89 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSCYTK_T2, HSCYTK_T11 and HSCYTK_T30. Table 2627 below describes the starting and ending position of this segment on each transcript.

Table 2627 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSCYTKJP2 and HSCYTKJP 10.

DESCRIPTION FOR CLUSTER HSGONA Cluster HSGONA features 1 transcript(s) and 13 segment(s) of interest, the names for which are given in Tables 2628 and 2629, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2630.

Table 2628 - Transcripts of interest

Transcript Name

HSGONA T8

Table 2629 - Segments of interest

Segment Name

HSGONA node O

HSGONA node 18

HSGONA node 21

HSGONA node 7

HSGONA node 9

HSGONA node 13

HSGONA node 15

HSGONA node 16

HSGONA node 17

HSGONA node 20

HSGONA node 22

HSGONA node 23

HSGONA node 26

Table 2630 - Proteins of interest

These sequences are variants of the known protein Glycoprotein hormones alpha chain precursor (SwissProt accession identifier GLHA_HUMAN; known also according to the synonyms Follitropin alpha chain; Follicle- stimulating hormone alpha chain; FSH-alpha; Lutropin alpha chain; Luteinizing hormone alpha chain; LSH- alpha; Thyrotropin alpha chain; Thyroid- stimulating hormone alpha chain; TSH-alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin alpha subunit; CG-alpha), referred to herein as the previously known protein. The sequence for protein Glycoprotein hormones alpha chain precursor is given at the end of the application, as "Glycoprotein hormones alpha chain precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2631.

Table 2631 - Amino acid mutations for Known Protein

Protein Glycoprotein hormones alpha chain precursor localization is believed to be Secreted.

The previously known protein also has the following indication(s) and/or potential

10 therapeutic use(s): Benign prostatic hyperplasia; Myelodysplastic syndrome; Infection, prostate;

Cancer, breast; Cancer, sarcoma, Kaposi's; Cancer, ovarian; Cancer, prostate; Cancer, gastrointestinal, stomach; Infertility, female; Infertility, male; Polycystic ovarian syndrome. It has been investigated for clinical/therapeutic use in humans, for example as a target for an

— — — antibody-or-small-molecule, and/or-as a-direct therapeutic-available -information-related to these-

15 investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Adenylate cyclase stimulant; Cyclic AMP agonist; Follicle- stimulating hormone agonist; LH agonist. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that

20 this protein, or part thereof, is used or can be used for a potential therapeutic indication: Prostate disorders; Hormone; Anticancer; Fertility enhancer.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: signal transduction; cell-cell signaling, which are annotation(s) related to Biological Process; hormone, which are annotation(s) related to Molecular Function;

25 and extracellular; soluble fraction, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/proj ects/LocusLink/>. As noted above, cluster HSGONA features 13 segment(s), which were listed in Table

2629 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSGONA_node_0 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA_T8. Table 2632 below describes the starting and ending position of this segment on each transcript.

Table 2632 - Segment location on transcripts

This segment can beTόund in a riόn- coding region of transcript(s)^~that are related to the following protein(s): HSGONA_P3.

Segment cluster HSGONA_node_18 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA_T8. Table 2633 below describes the starting and ending position of this segment on each transcript.

Table 2633 - Segment location on transcripts

This segment can be found in the following protein(s): HSGONA_P3. Segment cluster HSGONA_node_21 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA_T8. Table 2634 below describes the starting and ending position of this segment on each transcript.

Table 2634 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSGONA_P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment ^"cluster^~HSOOTSTA_nodeT7 according to^" the present mvention is supported by^~63^~ libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA T8. Table 2635 below describes the starting and ending position of this segment on each transcript.

Table 2635 - Segment location on transcripts

This segment can be found in the following protein(s): HSGONAJP3.

Segment cluster HSGONA_node_9 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA_T8. Table 2636 below describes the starting and ending position of this segment on each transcript. Table 2636 - Segment location on transcripts

This segment can be found in the following protein(s): HSGONA P3.

Segment cluster HSGONA_node_13 according to the present invention can be found in the following transcript(s): HSGONA_T8. Table 2637 below describes the starting and ending position of this segment on each transcript.

Table 2637 - Segment location on transcripts

This segment can be found in the following protein(s): HSGONA P3.

Segment cluster HSGONA_node_15 according to the present invention can be found in the following transcript(s): HSGONA_T8. Table 2638 below describes the starting and ending position of this segment on each transcript. Table 2638 - Segment location on transcripts

This segment can be found in the following protein(s): HSGONA_P3.

Segment cluster HSGONA_node_16 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA_T8. Table 2639 below describes the starting and ending position of this segment on each transcript.

Table 2639 - Segment location on transcripts

This segment can be found in the following protein(s): HSGONA_P3.

Segment cluster HSGONA_node_17 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA_T8. Table 2640 below describes the starting and ending position of this segment on each transcript.

Table 2640 - Segment location on transcripts

This segment can be found in the following protein(s): HSGONA_P3.

Segment cluster HSGONA_node_20 according to the present invention is supported by βTΕBraries. The number of libraries was determined as previously described. This segment can^" be found in the following transcript(s): HSGON A_T8. Table 2641 below describes the starting and ending position of this segment on each transcript.

Table 2641 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSGONA_P3.

Segment cluster HSGONA_node_22 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA_T8. Table 2642 below describes the starting and ending position of this segment on each transcript. Table 2642 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSGONA_P3.

Segment cluster HSGONA_node_23 according to the present invention can be found in the following transcript(s): HSGONA_T8. Table 2643 below describes the starting and ending position of this segment on each transcript.

Table 2643 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSGONA_P3.

Segment cluster HSGONA_node_26 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSGONA_T8. Table 2644 below describes the starting and ending position of this segment on each transcript.

Table 2644 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSGONA_P3.

DESCRIPTION FOR CLUSTER HSKERELP Cluster HSKERELP features 10 transcript(s) and 53 segment(s) of interest, the names for which are given in Tables 2645 and 2646, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2647.

Table 2645 - Transcripts of interest

Transcript Name

HSKERELP TO

HSKERELP T2

HSKERELP T6

HSKERELP T7

HSKERELP TI l

HSKERELP T13

HSKERELP T18

HSKERELP T23

HSKERELP T25

HSKERELP T32

Table 2646 - Segments of interest

SegnientName

HSKERELP node 0

HSKERELP node 1

HSKERELP node 45

HSKERELP node 57

HSKERELP node 60

HSKERELP node 64

HSKERELP node 2

HSKERELP node 3

HSKERELP node 4

HSKERELP_. node 5

HSKERELP node 6

HSKERELP node 7

HSKERELP node 8

HSKERELP node 9

HSKERELP node 10

HSKERELP node 11

HSKERELP node 12

HSKERELP node 13

HSKERELP node 14 HSKERELP node 15

HSKERELP node 16

HSKERELP node 17

HSKERELP node 18

HSKERELP node 19

HSKERELP node 20

HSKERELP node 21

HSKERELP node 25

HSKERELP node 27

HSKERELP node 28

HSKERELP node 29

HSKERELP node 30

HSKERELP node 31

HSKERELP node 35

HSKERELP node 36

HSKERELP node 37

HSKERELP node 38

HSKERELP node 39

HSKERELP node 40

HSKERELP node 41

HSKERELP node 42

HSKERELP node 43

HSKERELP node 46 HSKERELEL Jiode. 47.

HSKERELP node 49

HSKERELP node 50

HSKERELP node 51

HSKERELP node 52

HSKERELP node 53

HSKERELP node 54

HSKERELP node 56

HSKERELP node 61

HSKERELP node 62

HSKERELP node 63

Table 2647 - Proteins of interest

These sequences are variants of the known protein Keratin, type I cytoskeletal 17 (SwissProt accession identifier Kl CQJHUMAN; known also according to the synonyms Cytokeratin 17; K17; CK 17; 39.1), referred to herein as the previously known protein. Protein Keratin, type I cytoskeletal 17 is known or believed to have the following function(s): May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". The sequence for protein Keratin, type I cytoskeletal 17 is given at the end of the application, as "Keratin, type I cytoskeletal 17 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2648. Table 2648 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: epidermal differentiation, which are annotation(s) related to Biological Process; structural protein of cytoskeleton, which are annotation(s) related to Molecular Function; and intermediate filament, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBI Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HSKERELP can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 69 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 69 and Table 2649. This cluster is overexpressed (at least at a minimum level) in the following-pathological-conditions:- transitional_cell_carcinoma,-epithelial_malignant-tumors,_a- mixture of malignant tumors from different tissues, myosarcoma, pancreas carcinoma and uterine malignancies. Table 2649 - Normal tissue distribution

Table 2650 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSKERELP features 53 segment(s), which were listed in Table 2646 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSKERELP_node_0 according to the present invention is supported by 3 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP _T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2651 below describes the starting and ending position of this segment on each transcript.

Table 2651 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELPJP14, HSKERELP JP19, HSKERELP_P23, HSKERELP_P9 and HSKERELP P30.

Segment cluster HSKERELP_node_l according to the present invention is supported by 115 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELPjπ, HSKERELPjril, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2652 below describes the starting and ending position of this segment on each transcript. Table 2652 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELPJPl, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP P14, HSKERELP_P19, HSKERELP_P23 and HSKERELP P30.

Segment cluster HSKERELP_node_45 according to the present invention is supported by 255 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP _T32. Table 2653 below describes the starting and ending position of this segment on each transcript.

Table 2653 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELPJP14. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELPJP9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_57 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T2. Table 2654 below describes the starting and ending position of this segment on each transcript.

Table 2654 - Segment location on transcripts

JQiis_segment-can.be-found-in-theJbllowing-protein(s): HSKERELP-P3,

Segment cluster HSKERELP_node_60 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T2. Table 2655 below describes the starting and ending position of this segment on each transcript.

Table 2655 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P3. Segment cluster HSKERELP_node_64 according to the present invention is supported by 183 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2656 below describes the starting and ending position of this segment on each transcript.

Table 2656 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP JP7, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP_P23, HSKERELP JP9 and HSKERELP_P30. This segment can also be found in the following protein(s): HSKERELP_P8, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSKERELP_node_2 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T 1 1 , HSKERELP_T13, HSKEPvELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2657 below describes the starting and ending position of this segment on each transcript.

Table 2657 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP P19, HSKERELP P23 and HSKERELP P30.

Segment cluster HSKERELP_node_3 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2658 below describes the starting and ending position of this segment on each transcript.

Table 2658 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP_P23 and HSKERELP_P30.

Segment cluster HSKERELP_node_4 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2659 below describes the starting and ending position of this segment on each transcript.

Table 2659 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELPJPl, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P30.

Segment cluster HSKERELPjnode_5 according to the present invention is supported by 135 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2660 below describes the starting and ending position of this segment on each transcript. Table 2660 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELPJ¹I, HSKERELP_P3, HSKERELPJP7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P30.

Segment cluster HSKERELP_node_6 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP _T6,

HSKERELP T7, HSKERELP TI l, HSKERELP T.13, HSKERELP T.18, HSKERELP T23 and HSKERELP_T32. Table 2661 below describes the starting and ending position of this segment on each transcript.

Table 2661 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP__P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P30.

Segment cluster HSKERELP_node_7 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2662 below describes the starting and ending position of this segment on each transcript.

Table 2662 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELPJP14, HSKERELP_P19, HSKERELP_P23 and HSKERELP_P30.

Segment cluster HSKERELP_node_8 according to the present invention can be found in the following transcript(s): HSKERELP _TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2663 below describes the starting and ending position of this segment on each transcript.

Table 2663 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P30.

Segment cluster HSKERELP_node_9 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6,

HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2664 below describes the starting and ending position of this segment on each transcript.

Table 2664 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP J^>14, HSKERELP_P19, HSKERELP P23 and HSKERELP P30. Segment cluster HSKERELP_node_10 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2665 below describes the starting and ending position of this segment on each transcript.

Table 2665 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP Pl, HSKERELP P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P30.

Segment cluster HSKERELP_node_l 1 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T13, HSKERELP _T18, HSKERELP_T23 and

HSKERELP_T32. Table 2666 below describes the starting and ending position of this segment on each transcript.

Table 2666 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P14, HSKERELP_P19, HSKERELP_P23 and HSKERELP P30.

Segment cluster HSKERELP_node_12 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2667 below describes the starting and ending position of this segment on each transcript.

Table 2667 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P30.

Segment cluster HSKERELP_node_13 according to the present invention is supported by

132 libraries. The number of libraries was determined as previously described. This segment can be βund in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T32. Table 2668 below describes the starting and ending position of this segment on each transcript.

Table 2668 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELPJP12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P30.

Segment cluster HSKERELP_node_14 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T23 and HSKERELP_T32. Table 2669 below describes the starting and ending position of this segment on each transcript. Table 2669 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELPJP7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P23 and HSKERELP JP30.

Segment cluster HSKERELP_node_l 5 according to the present invention can be found in the following transcript(s): HSKERELPJTO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP__T23 and HSKERELP_T32. Table 2670 below describes the starting and ending position of this segment on each transcript.

Table 2670 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELPJP23 and HSKERELP P30.

Segment cluster HSKERELP_node_16 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2671 below describes the starting and ending position of this segment on each transcript.

Table 2671 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELP Pl, HSKERELP_P3, HSKERELP JP7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P23 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_17 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELPjπ, HSKERELPjm, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2672 below describes the starting and ending position of this segment on each transcript.

Table 2672 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP J^>12, HSKERELP P14, HSKERELP_P19, HSKERELP_P23 and HSKERELP P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELPjnode_l 8 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2673 below describes the starting and ending position of this segment on each transcript.

Table 2673 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP_P23 and HSKERELP_P30, since it is in the coding region for the corresponding transcript. Segment cluster HSKERELP_node_19 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKEPvELP_T32. Table 2674 below describes the starting and ending position of this segment on each transcript.

Table 2674 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP_P23 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_20 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6,

HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23,

HSKERELP_T25 and HSKERELP_T32. Table 2675 below describes the starting and ending position of this segment on each transcript.

Table 2675 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP P8, HSKERELP_P12, HSKERELP_P14, HSKERELP P19, HSKERELP_P23 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

^"Segment cluster HSKEREEP_nodeT21 accordingTo the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP _Tl 3, HSKERELP _Tl 8, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2676 below describes the starting and ending position of this segment on each transcript.

Table 2676 - Segment location on transcripts

I HSKERELP_T32 | 1 961 I I 972 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELPJP3, HSKERELP_P7, HSKERELP_P8, HSKERELPJP12, HSKERELP_P14, HSKERELP_P19, HSKERELP_P23 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_25 according to the present invention is supported by 172 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tll, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T25. Table 2677 below describes the starting and ending position of this segment on each transcript. Table 2677 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELPJU, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP P14, HSKERELP_P19 and HSKERELP_P23, since it is in the coding region for the corresponding transcript. Segment cluster HSKERELP_node_27 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, H8KERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP T13, HSKERELP_T18 and HSKERELP_T25. Table 2678 below describes the starting and ending position of this segment on each transcript.

Table 2678 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as ^bllowsτThe^~segmentτan be foumcHn-amorFCodingTegion-of transcrip^s^that-are related to the- following ρrotein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELPJP7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14 and HSKERELP_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_28 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18 and HSKERELP_T25. Table 2679 below describes the starting and ending position of this segment on each transcript.

Table 2679 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELPJPl, HSKERELP_P3, HSKERELPJP7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14 and HSKERELP_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_29 according to the present invention is supported by _172 Jibraries. JThejiumbeLθillibrarbsjTOS_djtermined^_preyiously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T25. Table 2680 below describes the starting and ending position of this segment on each transcript.

Table 2680 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P9. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19 and HSKERELP_P23, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_30 according to the present invention is supported by 183 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELPJTO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP T25. Table 2681 below describes the starting and ending position of this segment on each transcript.

Table 2681 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELPJP3, HSKERELP_P7₅ HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P9.

Segment cluster HSKERELP_node_31 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T25. Table 2682 below describes the starting and ending position of this segment on each transcript.

Table 2682 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP JPl, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P9.

_^Segment cluster HSKERELP node 35 according to the present invention can be found in_ the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP T7, HSKERELP_T11, HSKERELP T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP T25. Table 2683 below describes the starting and ending position of this segment on each transcript.

Table 2683 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELPJP1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P9.

Segment cluster HSKERELP_node_36 according to the present invention can be found in the following transcript(s): HSKERELPJTO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T25. Table 2684 below describes the starting and ending position of this segment on each transcript.

Table 2684 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP_P23 and HSKERELP_P9.

Segment cluster HSKERELP_node_37 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T25. Table 2685 below describes the starting and ending position of this segment on each transcript.

Table 2685 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP J^>23 and HSKERELP P9.

Segment cluster HSKERELP_node_38 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6,

HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23 and HSKERELP_T25. Table 2686 below describes the starting and ending position of this segment on each transcript.

Table 2686 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23 and HSKERELP P9. Segment cluster HSKERELP_node_39 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2687 below describes the starting and ending position of this segment on each transcript.

Table 2687 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP JPl, HSKERELP_P3,

HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23, HSKERELP_P9 and HSKERELP_P30.

Segment cluster HSKERELP_node_40 according to the present invention is supported by 193 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2688 below describes the starting and ending position of this segment on each transcript.

Table 2688 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELPJPl, HSKERELP_P3, HSKERELP_P7, HSKERELP__P8, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP_P23, HSKERELPJP9 and HSKERELP_P30.

Segment cluster HSKERELP_node_41 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, H8KERELP_T6,

HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23,

HSKERELP_T25 and HSKERELP_T32. Table 2689 below describes the starting and ending position of this segment on each transcript.

Table 2689 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELPJPl, HSKERELP_P3, HSKERELPJP7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P 19, HSKERELP_P23, HSKERELPJP9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_42 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELPJN l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2690 below describes the starting and ending position of this segment on each transcript.

Table 2690 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELPJP1, HSKERELP_P3, HSKERELP_P7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELP_P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_43 according to the present invention is supported by 199 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELPJB2. Table 2691 below describes the starting and ending position of this segment on each transcript.

Table 2691 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELP-P 1, HSKERELP_P3, HSKERELP J^>7, HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELP_P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_46 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T6. Table 2692 below describes the starting and ending position of this segment on each transcript.

Table 2692 - Segment location on transcripts

This segment can be found in the following protein(s): HSKERELP_P7. Segment cluster HSKERELP_node_47 according to the present invention is supported by 232 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2693 below describes the starting and ending position of this segment on each transcript.

Table 2693 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELPJPl, HSKERELP_P3, HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELP_P9 and HSKERELPJP30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_49 according to the present invention is supported by 248 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2694 below describes the starting and ending position of this segment on each transcript.

Table 2694 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELPJP1, HSKERELP_P3, HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELP_P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segmenf cluster HSKERELP_node_50 according tδ^~the presentrinventioiris supported by^" 252 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELPJTO, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2695 below describes the starting and ending position of this segment on each transcript. Table 2695 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELP_P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_51 according to the present invention is supported by 255 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2696 below describes the starting and ending position of this segment on each transcript. Table-2696— Segment location on-transcripts — - —

This segment can be found in both coding and non- coding legions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P8, HSKERELP_P12, HSKERELP_P 19, HSKERELP_P23, HSKERELP_P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_52 according to the present invention is supported by 252 librarie s. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP _T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2697 below describes the starting and ending position of this segment on each transcript.

Table 2697 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELP JPl, HSKERELP_P3₅ HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELP_P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_53 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6,

HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2698 below describes the starting and ending position of this segment on each transcript.

Table 2698 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P8, HSKERELP JP9 and^" HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_54 according to the present invention can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6,

HSKERELP_T7, HSKERELPjπ i, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2699 below describes the starting and ending position of this segment on each transcript.

Table 2699 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P8, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELP_P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_56 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELP_Tl l, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2700 below describes the starting and ending position of this segment on each transcript.

Table 2700 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P7 and HSKERELP-P 14. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P3, HSKERELP_P12, HSKERELP_P19, HSKERELP JP23, HSKERELP_P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_61 according to the present invention is supported by 235 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP _TO, HSKERELP _T2, HSKERELP _T6, HSKERELPjri l, HSKERELP _T13, HSKERELP_T18, HSKERELP_T23, HSKERELP _T25 and HSKERELP_T32. Table 2701 below describes the starting and ending position of this segment on each transcript. Table 2701 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P3, HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P12, HSKERELP_P19, HSKERELP_P23, HSKERELP P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_62 according to the present invention can be found in the following transcript(s): HSKERELP_TO, HSKERELP_T2, HSKERELP_T6, HSKERELPjril, HSKERELP_T13, HSKERELP _T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP _T32. Table 2702 below describes the starting and ending position of this segment on each transcript. Table 2702 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELP_P3, HSKERELP_P7 and HSKERELP_P14. This segment can also be found in the following protein(s): HSKERELP_P1, HSKERELP_P12, HSKERELP_P19, HSKERELPJP23, HSKERELP P9 and HSKERELP_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HSKERELP_node_63 according to the present invention is supported by

200 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSKERELP_T0, HSKERELP_T2, HSKERELP_T6, HSKERELP_T7, HSKERELP_T11, HSKERELP_T13, HSKERELP_T18, HSKERELP_T23, HSKERELP_T25 and HSKERELP_T32. Table 2703 below describes the starting and ending position of this segment on each transcript.

Table 2703 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSKERELPJP1, HSKERELPJP3, HSKERELP_P7, HSKERELP_P12, HSKERELP_P14, HSKERELP_P19, HSKERELP P23, HSKERELP_P9 and HSKERELPJP30. This segment can also be found in the following protein(s): HSKERELP_P8, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER HUMASHlA

Cluster HUMASHlA features 1 transcript(s) and 14 segment(s) of interest, the names for which are given in Tables 2704 and 2705, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2706.

Table 2704 - Transcripts of interest

Transcript Name

HUMASHlA Tl

Table 2705 - Segments of interest

Segment Nam<

HUMASHlA node 0

HUMASHlA node 1

HUMASHlA node 2

HUMASHlA node 7

HUMASHlA node 9

HUMASHlA node 11

HUMASHlA node 12

HUMASHlA node 3

HUMASHlA node 4

HUMASHlA node 5

HUMASHlA node 8

HUMASHlA node 10 HUMASHlA node 13

HUMASHlA node 14

Table 2706 - Proteins of interest

These sequences are variants of the known protein Achaete- scute homolog 1 (SwissProt accession identifier ASC1JHUMAN; known also according to the synonyms HASHl), referred to herein as the previously known protein.

Protein Achaete- scute homolog 1 is known or believed to have the following function(s): May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Activates transcription by binding to the E box (5'-CANNTG-3'). The sequence for protein Achaete- scute homolog 1 is given at the end of the application, as "Achaete-scute homolog 1 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2707.

Table 2707 - Amino acid mutations for Known Protein

Protein Achaete-scute homolog 1 localization is believed to be Nuclear (Probable).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription regulation, from Pol II promoter; neurogenesis; cell differentiation, which are annotation(s) related to Biological Process; transcription factor, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HUMASHlA can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 70 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 70 and Table 2708. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues and lung malignant tumors.

Table 2708 - Normal tissue distribution

Table 2709 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMASHlA features 14 segment(s), which were listed in Table

2705 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMASH lA_node_0 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A_T1. Table 2710 below describes the starting and ending position of this segment on each transcript.

Table 2710 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

presenFinventiόn is^~suppδffea By^"

10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHIA_TI. Table 2711 below describes the starting and ending position of this segment on each transcript.

Table 2711 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASHlA_node_2 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A_T1. Table 2712 below describes the starting and ending position of this segment on each transcript. Table 2712 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASH lA_node_7 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASH 1A_T1. Table 2713 below describes the starting and ending position of this segment on each transcript.

Table 2713 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASHlA_node_9 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A_T1. Table 2714 below describes the starting and ending position of this segment on each transcript.

Table 2714 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASH lA_node_l l according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A_T1. Table 2715 below describes the starting and ending position of this segment on each transcript. Table 2715 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASH lA_node_ 12 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A_T1. Table 2716 below describes the starting and ending position of this segment on each transcript.

Table 2716 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMASHlA_node_3 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A__T1. Table 2717 below describes the starting and ending position of this segment on each transcript.

Table 2717 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster HUMASH lA_node_4 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A_T1. Table 2718 below describes the starting and ending position of this segment on each transcript.

Table 2718 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASH lA_node_5 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A_T1. Table 2719 below describes the starting and ending position of this segment on each transcript.

Table 2719 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASH lA_node_8 according to the present invention can be found in the following transcript(s): HUMASHl A_T1. Table 2720 below describes the starting and ending position of this segment on each transcript.

Table 2720 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster HUMASH lA_node_10 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASH 1A_T1. Table 2721 below describes the starting and ending position of this segment on each transcript.

Table 2721 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASHlA_node_13 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A TI. Table 2722 below describes the starting and ending position of this segment on each transcript.

Table 2722 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMASH lA_node_ l 4 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMASHl A_T1. Table 2723 below describes the starting and ending position of this segment on each transcript.

Table 2723 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. DESCRIPTION FOR CLUSTER HUMCYCB

Cluster HUMCYCB features 10 transcript(s) and 19 segment(s) of interest, the names for which are given in Tables 2724 and 2725, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2726.

Table 2724 - Transcripts of interest

Transcript Name

HUMCYCB T4

HUMCYCB T5

HUMCYCB T6

HUMCYCB T9

HUMCYCB T12

HUMCYCB T16

HUMCYCB_, _T17

HUMCYCB T18

HUMCYCB T19

HUMCYCB -T20- _. . . — , —

Table 2725 - Segments of interest

Segment Name

HUMCYCB_ node 0

HUMCYCB node 1

HUMCYCB node 3

HUMCYCB node 9

HUMCYCB node 11

HUMCYCB node 18

HUMCYCB node 20

HUMCYCB node 23

HUMCYCB node 26

HUMCYCB node 27

HUMCYCB node 2

HUMCYCB node 6

HUMCYCB node 7

HUMCYCB node 13

HUMCYCB node 14 HUMCYCB node 15

HUMCYCB node 17

HUMCYCB node 24

HUMCYCB node 25

Table 2726 - Proteins of interest

These sequences are variants of the known protein G2/mitotic-specific cyclin Bl (SwissProt accession identifier CGB IJHUMAN), referred to herein as the previously known protein.

Protein G2/mitotic- specific cyclin Bl is known or believed to have the following function(s): Essential for the control of the cell cycle at the G2/M (mitosis) transition. The sequence for protein G2/mitotic- specific cyclin Bl is given at the end of the application, as "G2/mitotic- specific cyclin Bl amino acid sequence".

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell cycle control; G2/M transition of mitotic cell cycle; mitosis, which are annotation(s) related to Biological Process; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on hformation from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster HUMCYCB can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 71 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 71 and Table 2727. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, kidney malignant tumors, hepatocellular carcinoma, breast malignant tumors, myosarcoma, pancreas carcinoma, skin malignancies and uterine malignancies.

Table 2727 - Normal tissue distribution

Table 2728 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMCYCB features 19 segment(s), which were listed in Table 2725 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid squence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMCYCBjtiode_0 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMCYCB_T12. Table 2729 below describes the stalling and ending position of this segment on each transcript. Table 2729 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMCYCB_P2, HUMCYCB_P5 and HUMCYCB_P8.

Segment cluster HUMCYCB_node_l according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMCYCB_T12. Table 2730 below describes the starting and ending position of this segment on each transcript.

Table 2730 - Segment location on transcripts

Transcript name Segment Segment starting position ending position

HUMCYCB T4 136 271

HUMCYCB T5 136 271

HUMCYCB T6 136 271

HUMCYCB T9 136 271

HUMCYCB T12 136 271

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMCYCB_P8. This segment can also be found in the following protein(s): HUMCYCB_P2 and HUMCYCB_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HUMCYCB_node_3 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T12. Table 2731 below describes the starting and ending position of this segment on each transcript.

Table 2731 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB_P8.

Segment cluster HUMCYCB_node_9 according to the present invention is supported by 162 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMCYCB _Tl 2. Table 2732 below describes the starting and ending position of this segment on each transcript.

Table 2732 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB_P2, HUMCYCB_P5 and HUMCYCB P8.

Segment cluster HUMCYCB_node_l 1 according to the present invention is supported by

149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMCYCB_T12. Table 2733 below describes the starting and ending position of this segment on each transcript.

Table 2733 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB_P2, HUMCYCB JP5 and HUMCYCB_P8.

Segment cluster HUMCYCB_node_18 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6 and HUMCYCB_T12. Table 2734 below describes the starting and ending position of this segment on each transcript.

Table 2734 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCBJP2 and HUMCYCB_P8.

Segment cluster HUMCYCB_node_20 according to the present invention is supported by

129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMCYCB_T12. Table 2735 below describes the starting and ending position of this segment on each transcript. Table 2735 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCBJP2, HUMCYCB_P5 and HUMCYCB P8.

Segment cluster HUMCYCB_node_23 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T16, HUMCYCB_T17, HUMCYCB_T18, HUMCYCB_T19 and HUMCYCB_T20. Table 2736 below describes the starting and ending position of this segment on each transcript.

Table 2736 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMCYCB_node_26 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T17, HUMCYCB_T19 and HUMCYCB_T20. Table 2737 below describes the starting and ending position of this segment on each transcript.

Table 2737 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB P2.

Segment cluster HUMCYCB_node_27 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9, HUMCYCB_T12, HUMCYCB_T16, HUMCYCB_T17, HUMCYCB_T18, HUMCYCB_T 19 and HUMCYCB_T20. Table 2738 below describes the starting and ending position of this segment on each transcript.

Table 2738 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMCYCB_P2 and HUMCYCB_P5. This segment can also be found in the following protein(s): HUMCYCB_P8, since it is in the coding region for the corresponding transcript. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMCYCB_node_2 according to the present invention can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMC YCB_Tl 2. Table 2739 below describes the starting and ending position of this segment on each transcript. Table 2739 - Segment location on transcripts

— This— segment-can-be-found-in-both-eodmg-and-nen-eoding-regiens-ef-transeript(s)-as- follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMCYCB_P8. This segment can also be found in the following protein(s): HUMCYCB_P2 and HUMCYCB_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HUMCYCB_node_6 according to the present invention is supported by

174 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6,

HUMCYCB_T9 and HUMCYCB_T12. Table 17 below describes the starting and ending position of this segment on each transcript.

Table 2740 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB_P2, HUMCYCB_P5 and HUMCYCB_P8.

Segment cluster HUMCYCB_node_7 according to the present invention is supported by 175 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMCYCB_T12. Table 2741 below describes the starting and ending position of this segment on each transcript.

Table 2741 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB_P2, HUMCYCB_P5 and HUMCYCB P8.

Segment cluster HUMCYCB_node_13 according to the present invention is supported by

127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMCYCB_T12. Table 2742 below describes the starting and ending position of this segment on each transcript. Table 2742 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB_P2, HUMCYCB_P5 and HUMCYCB_P8.

Segment cluster HUMCYCB node_l 4 according to the present invention can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB_T9 and HUMCYCB_T12. Table 2743 below describes the starting and ending position of this segment on each transcript.

Table 2743 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB_P2, HUMCYCB_P5 and HUMCYCB P8.

Segment cluster HUMCYCB_node_15 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6,

HUMCYCB_T9 and HUMCYCB_T12. Table 2744 below describes the starting and ending position of this segment on each transcript.

Table 2744 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCYCB_P2, HUMCYCB_P5 and HUMCYCB_P8.

Segment cluster HUMCYCB_node_17 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB _T4, HUMCYCB _T5, HUMCYCB_T6, HUMCYCB T9 and HUMCYCB_T12. Table 22 below describes the starting and ending position of this segment on each transcript.

This segment can be found in the following protein(s): HUMCYCB_P2, HUMCYCB_P5 and HUMCYCB P8.

Segment cluster HUMCYCB_node_24 according to the present invention is supported by

127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB _T4, HUMCYCB_T5, HUMCYCB_T6, HUMCYCB _T9, HUMCYCB_T12, HUMCYCB_T16, HUMC YCB_Tl 7, HUMCYCB_T18, HUMCYCB_T19 and HUMCYCB _T20. Table 2746 below describes the starting and ending position of this segment on each transcript.

Table 2746 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMCYCB_P5. This segment can also be found in the following protein(s): HUMCYCB_P2 and HUMCYCB_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMCYCB_node_25 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCYCB_T4, HUMCYCB_T5, HUMCYCB_T6, iUMCYCBJ9,_HUMCYCB JQ12, HUMCYCB TL6, _^HUMCYCBJUI₅-HUMCYCB-TI 8,_ HUMCYCB_T19 and HUMCYCB_T20. Table 2747 below describes the starting and ending position of this segment on each transcript.

Table 2747 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMCYCB P5. This segment can also be found in the following protein(s): HUMCYCB_P2 and HUMCYCB_P8, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER HUMDNAPOLD

Cluster HUMDNAPOLD features 4 transcript(s) and 44 segment(s) of interest, the names for which are given in Tables 2748 and 2749, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2750.

Table 2748 - Transcripts of interest

Transcript Name

HUMDNAPOLD Tl

HUMDNAPOLD T8

HUMDNAPOLD T15

-HUMDNAPOLD -T24-

Table 2749 - Segments of interest

Segment Name

HUMDNAPOLD node 2

HUMDNAPOLD node 6

HUMDNAPOLD node 8

HUMDNAPOLD node 14

HUMDNAPOLD node 16

HUMDNAPOLD node 18

HUMDNAPOLD node 22

HUMDNAPOLD node 26

HUMDNAPOLD node 36

HUMDNAPOLD node 54

HUMDNAPOLD node 62

HUMDNAPOLD node 68

HUMDNAPOLD node 74

HUMDNAPOLD node 0

HUMDNAPOLD node 4 HUMDNAPOLD node 9

HUMDNAPOLD node 10

HUMDNAPOLD node 12

HUMDNAPOLD node 20

HUMDNAPOLD node 24

HUMDNAPOLD node 25

HUMDNAPOLD node 29

HUMDNAPOLD node 31

HUMDNAPOLD node 32

HUMDNAPOLD_ node_ _34

HUMDNAPOLD node 38

HUMDNAPOLD node 41

HUMDNAPOLD node 43

HUMDNAPOLD node 46

HUMDNAPOLD node 47

HUMDNAPOLD node 49

HUMDNAPOLD node 51

HUMDNAPOLD node 52

HUMDNAPOLD node 56

HUMDNAPOLD node 57

HUMDNAPOLD node 61

HUMDNAPOLD node 63

HUMDNAPOLD node 64 HUMDNΔPQLD. _node 65 .

HUMDNAPOLD node 66

HUMDNAPOLD_ node_ _69

HUMDNAPOLD node 70

HUMDNAPOLD node 72

HUMDNAPOLD node 75

Table 2750 - Proteins of interest

These sequences are variants of the known protein DNA polymerase delta catalytic subunit (SwissProt accession identifier DPOD_HUMAN; known also according to the synonyms EC 2.7.7.7; DNA polymerase delta subunit pl25), referred to herein as the previously known protein. Protein DNA polymerase delta catalytic subunit is known or believed to have the following function(s): Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3' to 5' direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. The sequence for protein DNA polymerase delta catalytic subunit is given at the end of the application, as "DNA polymerase delta catalytic subunit amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2751.

Table 2751 -Amino acid mutations for Known Protein

-Protein DNA-polymerase-delta catalytic subunit localization-is believed-to be Nuclear-

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: DNA replication; DNA repair; response to UV, which are annotation(s) related to Biological Process; nucleotide binding; DNA binding; delta DNA polymerase; 3'-5' exonuclease; transferase; hydrolase, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http ://www.ncbi.nlm.nih. gov/proj ects/LocusLink/>. Cluster HUMDNAPOLD can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 72 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 72 and Table 2752. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, myosarcoma and skin malignancies.

Table 2752 - Normal tissue distribution

Table 2753 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMDNAPOLD features 44 segment(s), which were listed in

Table 2749 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMDNAPOLD_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl. Table 2754 below describes the starting and ending position of this segment on each transcript.

Table 2754 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLDJP1.

Segment cluster HUMDNAPOLD_node_6 according to the present invention is supported by 1 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD T1. Table 2755 below describes the starting and ending position of this segment on each transcript.

Table 2755 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAP OLD Pl.

Segment cluster HUMDNAPOLD_node_8 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment — -can -be- found-in-the_following -transcript(s):- HUMDNAEOLD-X1 , -HUMDNAPOLD_T8-and_ HUMDNAPOLD_T15. Table 2756 below describes the starting and ending position of this segment on each transcript.

Table 2756 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD_P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_14 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2757 below describes the starting and ending position of this segment on each transcript.

Table 2757 - Segment location on transcripts

5 This segment can be found in the following protein(s): HUMDNAPOLD_P1 and

HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_l 6 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This

10 segment can be found in the following transcript(s): HUMDNAPOLD_T1,

HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2758 below describes the starting and ending position of this segment on each transcript.

— — — Table 2758- Segment.location an transcripts —

15 This segment can be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_18 according to the present invention is supported by 36 libraries. The number of libraries was deteπnined as previously described. This

20 segment can be found in the following transcript(s): HUMDNAPOLD Tl,

HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2759 below describes the starting and ending position of this segment on each transcript.

Table 2759 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAP OLD_P7.

Segment cluster HUMDNAPOLD_node_22 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8 and HUMDNAP0LD_T15. Table 2760 below describes the starting and ending position of this segment on each transcript.

Table 2760 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD Pl and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_26 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2761 below describes the starting and ending position of this segment on each transcript. Table 2761 - Segment location on transcripts

HUMDNAPOLD Tl 5 1078 1206

This segment can be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_36 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD T1, HUMDNAPOLD_T8 and HUMDNAPOLD _Tl 5. Table 2762 below describes the starting and ending position of this segment on each transcript.

Table 2762 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD_P1 and -HUMDNAPOLD F7- — — —

Segment cluster HUMDNAPOLD_node_54 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2763 below describes the starting and ending position of this segment on each transcript. Table 2763 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAPOLD P7. Segment cluster HUMDNAPOLD_node_62 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2764 below describes the starting and ending position of this segment on each transcript.

Table 2764 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 2765.

Table 2765 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMDN APOLD P7.

Segment cluster HUMDNAPOLD_node_68 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T24. Table 2766 below describes the starting and ending position of this segment on each transcript.

Table 2766 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD_P21. Segment cluster HUMDNAPOLD_node_74 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8, HUMDNAPOLD_T15 and HUMDNAPOLD_T24. Table 2767 below describes the starting and ending position of this segment on each transcript.

Table 2767 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLD_P7. This segment can also be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAPOLD_P21, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMDNAPOLD_node_0 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8 and

HUMDNAPOLD_T15. Table 2768 below describes the starting and ending position of this segment on each transcript.

Table 2768 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLD P1. This segment can also be found in the following protein(s): HUMDNAPOLD_P7, since it is in the coding region for the corresponding transcript.

Segment cluster HUMDNAPOLD_node_4 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl. Table 2769 below describes the starting and ending position of this segment on each transcript.

Table 2769 - Segment location on transcripts

Transcript name Segment Segment starting position ending position

HUMDNAPOLD Tl 214 302

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : HUMDNAPOLD_P 1.

Segment cluster HUMDNAPOLD_node_9 according to the present invention can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2770 below describes the starting and ending position of this segment on each transcript.

Table 2770 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD Pl and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_10 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2771 below describes the starting and ending position of this segment on each transcript.

Table 2771 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_12 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2772 below describes the starting and ending position of this segment on each transcript.

Table 2772 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD-Pl and HUMDNAPOLD P7. Segment cluster HUMDNAPOLD_node_20 according to the present invention is supported by 34 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2773 below describes the starting and ending position of this segment on each transcript.

Table 2773 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD Pl and HUMDNAPOLD_P7.

Segment cluster HUMDNAPOLD_node_24 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAP0LD_T8 and HUMDNAPOLD_T15. Table 2774 below describes the starting and ending position of this segment on each transcript.

Table 2774 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD_P1 and HUMDNAPOLD_P7.

Segment cluster HUMDNAPOLD_node_25 according to the present invention can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8 and 02438

1618

HUMDNAPOLD_T15. Table 2775 below describes the starting and ending position of this segment on each transcript.

Table 2775 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD-Pl and

HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_29 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1,

HUMDNAPOLD_T8 and HUMDNAPOLD _Tl 5. Table 2776 below describes the starting and ending position of this segment on each transcript. Table 277.6-- Segment location on transcripts- — ■ — ■ —

This segment can be found in the following protein(s): HUMDN APOLD Pl and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_31 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD Tl,

HUMDNAPOLD_T8 and HUMDNAP0LD_T15. Table 2777 below describes the starting and ending position of this segment on each transcript.

Table 2777 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAPOLD_P7.

Segment cluster HUMDNAPOLD_node_32 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2778 below describes the starting and ending position of this segment on each transcript.

Table 2778 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_34 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAP0LD_T8 and HUMDNAPOLD_T15. Table 2779 below describes the starting and ending position of this segment on each transcript. Table 2779 - Segment location on transcripts

HUMDNAPOLD Tl 5 1453 1563

This segment can be found in the following protein(s): HUMDNAPOLD P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_38 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2780 below describes the starting and ending position of this segment on each transcript.

Table 2780 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD_P1 and HUMDNAPOLD P7-. — — —

Segment cluster HUMDN APOLD_node_41 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2781 below describes the starting and ending position of this segment on each transcript. Table 2781 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD Pl and HUMDNAPOLD P7. Segment cluster HUMDNAPOLD_node_43 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2782 below describes the starting and ending position of this segment on each transcript.

Table 2782 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD_P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_46 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2783 below describes the starting and ending position of this segment on each transcript.

Table 2783 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD_P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_47 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8 and HUMDN APOLD_Tl 5. Table 2784 below describes the starting and ending position of this segment on each transcript.

Table 2784 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD Pl and HUMDNAPOLD_P7.

Segment cluster HUMDNAPOLD_node_49 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1,

HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2785 below describes the starting and ending position of this segment on each transcript.

Table 2785 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD Pl and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_51 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl,

HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2786 below describes the starting and ending position of this segment on each transcript. Table 2786 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD_P1 and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_52 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8 and HUMDN APOLD_Tl 5. Table 2787 below describes the starting and ending position of this segment on each transcript.

Table 2787 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLD Pl and HUMDNAPOLD_P7.

Segment cluster HUMDNAPOLD_node_56 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD T8 and HUMDNAPOLD_T15. Table 2788 below describes the starting and ending position of this segment on each transcript.

Table 2788 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDN APOLDJPl and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD_node_57 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2789 below describes the starting and ending position of this segment on each transcript.

Table 2789 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD Pl and HUMDNAPOLD P7.

Segment cluster HUMDNAPOLD node_61 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD Tl, HUMDNAP0LD_T8 and HUMDNAPOLD_T15. Table 2790 below describes the starting and ending position of this segment on each transcript. Table 2790 - Segment location on transcripts

This segment can be found in the following protein(s): HUMDNAPOLD_P 1 and HUMDNAPOLD Vl.

Segment cluster HUMDNAPOLD_node_63 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2791 below describes the starting and ending position of this segment on each transcript.

Table 2791 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLDJP7. This segment can also be found in the following protein(s): HUMDNAPOLD_P1, since it is in the coding region for the corresponding transcript.

Segment cluster HUMDNAPOLD_node_64 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2792 below describes the starting and ending position of this segment on each transcript.

Table 2792 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLD_P7. This segment can also be found in the following protein(s): HUMDNAPOLD_P1, since it is in the coding region for the corresponding transcript.

Segment cluster HUMDNAPOLD_node_65 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD T15. Table 2793 below

10 describes the starting and ending position of this segment on each transcript.

Table 2793 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLDJP7.

ID

Segment cluster HUMDNAPOLD_node_66 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8 and HUMDNAPOLD_T15. Table 2794 below describes the starting and 0 ending position of this segment on each trans cript.

Table 2794 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the

25 following protein(s): HUMDNAPOLD_P7. This segment can also be found in the following protein(s): HUMDNAPOLD_P1, since it is in the coding region for the corresponding transcript.

Segment cluster HUMDNAPOLD_node_69 according to the present invention can be found in the following transcript(s): HUMDNAPOLD_T1, HUMDNAPOLD_T8, HUMDNAPOLD_T15 and HUMDN APOLD_T24. Table 2795 below describes the starting and ending position of this segment on each transcript.

Table 2795 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDN APOLD P7. This segment can also be found in the following protein(s7THUMDNAPOLD_Pr and HUMDNAPOLDJP21, since it is in the coding region for the corresponding transcript.

Segment cluster HUMDNAPOLD_node_70 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAPOLD_T8, HUMDNAPOLD_T15 and HUMDNAPOLD_T24. Table 2796 below describes the starting and ending position of this segment on each transcript.

Table 2796 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLD_P7. This segment can also be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAPOLD_P21, since it is in the coding region for the corresponding transcript.

Segment cluster HUMDNAPOLD_node_72 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD T1,

HUMDNAPOLD_T8, HUMDNAPOLD_T15 and HUMDNAPOLD_T24. Table 2797 below describes the starting and ending position of this segment on each transcript.

Table 2797 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLD_P7. This segment can also be found in the following protein(s): HUMDNAPOLD_P1 and HUMDNAPOLD_P21, since it is in the coding region for the corresponding transcript.

Segment cluster HUMDNAPOLD_node_75 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMDNAPOLD_Tl, HUMDNAP0LD_T8, HUMDNAPOLD_T15 and HUMDNAPOLD_T24. Table 2798 below describes the starting and ending position of this segment on each transcript.

Table 2798 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMDNAPOLD_P1, HUMDN APOLD P7 and HUMDNAPOLDJP21.

DESCRIPTION FOR CLUSTER HUMETRl 03

Cluster HUMETRl 03 features 2 transcript(s) and 19 segment(s) of interest, the names for which are given in Tables 2799 and 2800, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2801.

Table 2799 - Transcripts of interest

Transcript Name -

HUMETRl 03 T3

HUMETRl 03 T8

Table 2800 - Segments of interest

Segment Name

HUMETRl 03 node 1

HUMETRl 03 node 5

HUMETRl 03 node 7

HUMETRl 03 node 9

HUMETR103 node 12

HUMETRl 03 node 15

HUMETR103 node 20

HUMETRl 03 node 0

HUMETRl 03 node 2

HUMETRl 03 node 3

HUMETR103 node 4

HUMETRl 03 node 6

HUMETR103 node 8 HUMETRl 03 node 10

HUMETRl 03 node 11

HUMETR103 node 13

HUMETRl 03 node 16

HUMETRl 03 node 18

HUMETRl 03 node 19

Table 2801 - Proteins of interest

These sequences are variants of the known protein Early growth response protein 1 (SwissProt accession identifier EGRl-HUMAN; known also according to the synonyms EGR-

1; Krox-24 protein; ZIF268; Nerve growth factor- induced protein A; NGFI-A; Transcription factor ETR103; Zinc finger protein 225; AT225), referred to herein as the previously known protein.

Protein Early growth response protein 1 is known or believed to have the following function(s): Transcriptional regulator. Recognizes and binds to the DNA sequence 5'- CGeeCCCGC-3'(EGR^::site)7^~Activates-the-transcription— of target -genes- whose-products^~are- required for mitogenesis and differentiation. The sequence for protein Early growth response protein 1 is given at the end of the application, as "Early growth response protein 1 amino acid sequence". Protein Early growth response protein 1 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription regulation, which are annotation(s) related to Biological Process; transcription factor, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProf TremBl Protein knowledgebase, available fom <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>. Cluster HUMETRl 03 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 73 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 73 and Table 2802. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, a mixture of malignant tumors from different tissues and prostate cancer.

Table 2802 - Normal tissue distribution

Table 2803 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMETRl 03 features 19 segment(s), which were listed in Table 2800 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMETRl 03_node_l according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2804 below describes the starting and ending position of this segment on each transcript.

Table 2804 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMETRl 03_P4. This segment can also be found in the following protein(s): HUMETR 1O3_P1, since it is in the coding region for the corresponding transcript.

Segment cluster HUMETRl 03_node_5 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3. Table 2805 below describes the starting and ending position of this segment on each transcript.

Table 2805 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMETRl 03_P4.

Segment cluster HUMETRl 03_node_7 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2806 below describes the starting and ending position of this segment on each transcript.

Table 2806 - Segment location on transcripts

This segment can be found in the following protein(s): HUMETRl 03_P4 and HUMETR103 Pl. Segment cluster HUMETR 103_node_9 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR1O3_T8. Table 2807 below describes the starting and ending position of this segment on each transcript.

Table 2807 - Segment location on transcripts

This segment can be found in the following protein(s): HUMETRl 03 JP4 and HUMETRl 03JP 1.

Segment cluster HUMETRl 03_node_l 2 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2808-below-describes th& starting and-ending-position-of-this segment-on each transcript.— — — - -

Table 2808 - Segment location on transcripts

This segment can be found in the following protein(s): HUMETRl 03 P4 and HUMETR103 Pl.

Segment cluster HUMETRl 03_node_l 5 according to the present invention is supported by 371 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2809 below describes the starting and ending position of this segment on each transcript.

Table 2809 - Segment location on transcripts

This segment can be found in the following protein(s): HUMETRl 03_P4 and HUMETRl 03 Pl.

Segment cluster HUMETRl 03_node_20 according to the present invention is supported by 266 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103 T3 and HUMETR103_T8. Table 2810 below describes the starting and ending position of this segment on each transcript.

Table 2810 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMETRl 03_P4 and HUMETRl 03 Pl.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMETRl 03_node_0 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETRl 03_T8. Table 2811 below describes the starting and ending position of this segment on each transcript.

Table 2811 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMETRl 03_P4 and HUMETRl O3_P1.

Segment cluster HUMETRl 03_node_2 according to the present invention can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2812 below describes the starting and ending position of this segment on each transcript.

Table 2812 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMETRl 03 P4. This segment can also be found in the following protein(s):-HUMET-R103_Pl— sinee-it-is-in-the-eoding region for the corresponding transcript.-

Segment cluster HUMETRl 03_node_3 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2813 below describes the starting and ending position of this segment on each transcript.

Table 2813 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMETRl 03_P4. This segment can also be found in the following protein(s): HUMETR103_Pl, since it is in the coding region for the corresponding transcript.

Segment cluster HUMETRl 03_node_4 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2814 below describes the starting and ending position of this segment on each transcript.

Table 2814 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMETRl 03_P4. This segment can also be found in the following protein(s): HUMETR103JP1, since it is in the coding region for the corresponding transcript.

Segment cluster HUMETRl 03_node_6 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2815 below describes the starting and ending position of this segment on each transcript.

Table 2815 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMETRl 03_P4. This segment can also be found in the following protein(s): HUMETRl 03_Pl, since it is in the coding region for the corresponding transcript. Segment cluster HUMETRl 03_node_8 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETRl 03_T3 and HUMETR103_T8. Table 2816 below describes the starting and ending position of this segment on each transcript.

Table 2816 - Segment location on transcripts

This segment can be found in the following protein(s): HUMETRl 03 P4 and HUMETR103JP1.

Segment cluster HUMETRl 03_node_10 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR1O3_T3 and HUMETR103_T8. Table 2817 below describes the starting and ending position of this segment on each transcript.

^"Table 2817 ^Segmenflocation on transcripts ^{~ " ~~~}

This segment can be found in the following protein(s): HUMETRl 03_P4 and HUMETRl 03 Pl.

Segment cluster HUMETRl 03_node_l l according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2818 below describes the starting and ending position of this segment on each transcript.

Table 2818 - Segment location on transcripts

This segment can be found in the following protein(s): HUMETR103_P4 and HUMETRl 03 Pl.

Segment cluster HUMETRl 03_node_l 3 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETR103_T8. Table 2819 below describes the starting and ending position of this segment on each transcript.

Table 2819 - Segment location on transcripts

This segment can be found in the following protein(s): HUMETRl 03_P4 and

HUMETRl 03 Pl.

Segment cluster HUMETRl 03_node_l 6 according to the present invention can be found in the following transcript(s): HUMETRl 03_T3 and HUMETRl 03_T8. Table 2820 below describes the starting and ending position of this segment on each transcript.

Table 2820 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMETR103_P4 and HUMETR103_Pl. Segment cluster HUMETRl 03_node_ 18 according to the present invention is supported by 248 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETR103_T3 and HUMETRl 03_T8. Table 2821 below describes the starting and ending position of this segment on each transcript.

Table 2821 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMETRl 03_P4 and HUMETRl O3_P1.

Segment cluster HUMETRl 03__node_ l 9 according to the present invention is supported by 253 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMETRl 03_T3 and HUMETRl 03_T8. Table 2822 below describes the starting and ending position of this segment on each transcript.

Table^~2822 - Segment location on transcripts ^{~ ~~~ ~~}

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMETR103_P4 and HUMETR 103JP1.

DESCRIPTION FOR CLUSTER HUMGRP5E

Cluster HUMGRP5E features 1 transcript(s) and 4 segment(s) of interest, the names for which are given in Tables 2823 and 2824, respectively, the sequences themselves are given at the end of the application. The selected protein variants are givenin Table 2825. Table 2823 - Transcripts of interest

Transcript Name

HUMGRP5E T3

Table 2824 - Segments of interest

Segment Name

HUMGRP5E node 5

HUMGRP5E node 8

HUMGRP5E node 6

HUMGRP5E node 7

Table 2825 - Proteins of interest

These sequences are variants of the known protein Gastrin-releasing peptide precursor (SwissProt accession identifier GRP-HUMAN; known also according to the synonyms GRP; GRP-IO), referred to herein as the previously known protein.

Protein Gastrin-releasing peptide precursor is known or believed to have the following function(s): GRP stimulates gastrin release as well as other gastrointestinal hormones^' The sequence for protein Gastrin-releasing peptide precursor is given at the end of the application, as "Gastrin-releasing peptide precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2826.

Table 2826 - Amino acid mutations for Known Protein

Protein Gastrin-releasing peptide precursor localization is believed to be Secreted.

The previously known protein also has the following indication(s) and/or potential therapeutic use(s): Diabetes, Type II. It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Bombesin antagonist; Insulinotropin agonist. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was infoπnation in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Anorectic/Antiobesity; Releasing hormone; Anticancer; Respiratory; Antidiabetic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: signal transduction; neuropeptide signaling pathway, which are annotation(s) related to Biological Process; growth factor, which are annotation(s) related to Molecular Function; and soluble fraction, which are annotation(s) related to Cellular

Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the-cluster,-although~not of at least -one-transcript/segment-as-listed. below —Microarray (chip) - data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 2827.

Table 2827 - Oligonucleotides related to this cluster

As noted above, cluster HUMGRP5E features 4 segment(s), which were listed in Table 2824 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMGRP5E_node_5 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGRP5E T3. Table 2828 below describes the starting and ending position of this segment on each transcript.

Table 2828 - Segment location on transcripts

10 The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMGRP5E_node_8 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGRP5E T3. Table 2829 below describes the ^~15^~~~starting and^"endiiig positioifof this^~segmeήt^"όh each transcript. ^{~ ~ ~ ~ ~~~}

Table 2829 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

20

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster HUMGRP5E_node_6 according to the present invention can be found in the following transcript(s): HUMGRP5E_T3. Table 2830 below describes the starting and ending position of this segment on each transcript.

Table 2830 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMGRP5E_node_7 according to the present invention can be found in the following transcript(s): HUMGRP5E_T3. Table 2831 below describes the starting and ending position of this segment on each transcript.

Table 2831 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER HUMIFN 15K

Cluster HUMIFNl 5K features 6 transcript(s) and 10 segment(s) of interest, the names for which are given in Tables 2832 and 2833, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2834.

Table 2832 - Transcripts of interest

Transcript Name

HUMIFN15K Tl

HUMIFNl 5K T2

HUMIFNl 5K T3 HUMIFN 15K T4

HUMIFN 15K T5

HUMIFNl 5K T6

Table 2833 - Segments of interest

Segment Name

HUMIFNl 5K node 0

HUMIFN15K node 1

HUMIFN 15K node 4

HUMIFN 15K node 11

HUMIFNl 5K node 12

HUMIFNl 5K node 13

HUMIFN 15K node 2

HUMIFNl 5K node 5

HUMIFN15K node 7

HUMIFN 15K node 9

Table 2834 - Proteins of interest

These sequences are variants of the known protein Ubiquitin cross-reactive protein precursor (SwissProt accession identifier UCRP_HUMAN; known also according to the synonyms Interferon- induced 17 kDa protein; Interferon- induced 15 kDa protein), referred to herein as the previously known protein. Protein Ubiquitin cross-reactive protein precursor is known or believed to have the following function(s): Acts as ubiquitin by conjugation to intracellular target proteins, through an enzyme pathway distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. Targets include SERPINA3G/SPI2A, JAKl, MAPK3/ERK1 and PLCGl. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. The sequence for protein Ubiquitin cross-reactive protein precursor is given at the end of the application, as "Ubiquitin cross-reactive protein precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2835.

Table 2835 - Amino acid mutations for Known Protein

Protein Ubiquitin cross-reactive protein precursor localization is believed to be Cytoplasmic (UCRP conjugates seem to be noncovalently associated with the intermediate filaments and distributed in a punctate pattern) and secreted.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were- found: -immune-response;-cell-cell signaling,-which are annotation(s) related - to Biological Process; protein binding, which are annotation(s) related to Molecular Function; and extracellular space; cytoplasm, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster HUMIFN 15K can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 74 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 74 and Table 2836. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors and breast malignant tumors.

Table 2836 - Normal tissue distribution

Table 2837 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMIFN 15K features 10 segment(s), which were listed in Table 2833 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMIFNl 5K_node_0 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMIFN15K_T1, HUMIFN15K_T4 and HUMIFN 15K_T6. Table 2838 below describes the starting and ending position of this segment on each transcript.

Table 2838 - Segment location on transcripts

This segment can be found in the following protein(s): HUMIFN15K_P2 and HUMIFN15KJP4.

Segment cluster HUMIFN 15K_node_l according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMIFN15K_T1 and HUMIFN15K T6. Table 2839 below describes the starting and ending position of this segment on each transcript.

Table 2839 - Segment location on transcripts

This segment can be found in the following protein(s): HUMIFNl 5K_P2.

Segment cluster HUMIFN 15K_node_4 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMIFN15K_T2 and HUMIFN15K_T3. Table 2840 below describes the starting and ending position of this segment on each transcript.

Table 2840 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMIFN15KJP3.

Segment cluster HUMIFNl 5K_node_l l according to the present invention is supported by 194 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMIFN15K_T5. Table 2841 below describes the starting and ending position of this segment on each transcript.

Table 2841 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMIFN 15K_P3.

Segment cluster HUMIFNl 5K_node_l 2 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMIFN15K_T5. Table 2842 below describes the starting and ending position of this segment on each transcript.

Table 2842 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMIFNl 5K_P3.

Segment cluster HUMIFN 15K_node_l 3 according to the present invention is supported by 258 libraries. The number of libraries was determined as previously described. This segment can^~be^~Tόund in^{~^}the^~fόllόwing^~lralπicΗpT(sir^~HUMIFN15K^T17^~πBπDMIFNr5KlT2r HUMIFN15K_T3, HUMIFN15K_T4 and HUMIFN 15K_T5. Table 2843 below describes the starting and ending position of this segment on each transcript.

Table 2843 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMIFNl 5K_P2 and HUMIFNl 5K_P4. This segment can also be found 2438

1651 in the following protein(s): HUMIFNl 5K_P3, since it is in the coding region for the corresponding transcript.

5 According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMIFNl 5K_node_2 according to the present invention is supported by 0 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMIFNl 5K_T6. Table 2844 below describes the starting and ending position of this segment on each transcript.

Table 2844 - Segment location on transcripts

f5^~ This segment can be found in a non-coding region of transcript(sythat are related to the^" following protein(s): HUMIFN15K_P2.

Segment cluster HUMIFNl 5K_node_5 according to the present invention can be found in the following transcript(s): HUMIFNl 5K_T2. Table 2845 below describes the starting and 0 ending position of this segment on each transcript.

Table 2845 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMIFNl 5KJP3. 5 Segment cluster HUMIFN 15K_node_7 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMIFN 15K_T1. Table 2846 below describes the starting and ending position of this segment on each transcript.

Table 2846 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMIFNl 5K_P2.

Segment cluster HUMIFN 15K_node_9 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMIFN15K_T1, HUMIFN15K_T2, HUMIFN15K_T3 and HUMIFNl 5K_T4. Table 2847 below describes the starting and ending position of this segment on each transcript. Table 2847 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMIFNl 5K_P2 and HUMIFNl 5KJP3. This segment can also be found in the following protein(s): HUMIFNl 5K_P4, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER HUMPKM2L Cluster HUMPKM2L features 5 transcript(s) and 120 segment(s) of interest, the names for which are given in Tables 2848 and 2849, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2850.

Table 2848 - Transcripts of interest

Transcript Name

HUMPKM2L T6

HUMPKM2L T9

HUMPKM2L T27

HUMPKM2L T41

HUMPKM2L T65

Table 2849 - Segments of interest

Segment Name

HUMPKM2L node 2

HUMPKM2L node 3

HUMPKM2L node 11

HUMPKM2L node 12

HUMPKM2L node 38

HUMPKM2Lr node DO

HUMPKM2L node 155

HUMPKM2L node 4

HUMPKM2L node 10

HUMPKM2L node 14

HUMPKM2L node 16

HUMPKM2L node 19

HUMPKM2L node 20

HUMPKM2L node 21

HUMPKM2L node 22

HUMPKM2L node 23

HUMPKM2L node 24

HUMPKM2L node 25

HUMPKM2L node 29

HUMPKM2L node 30

HUMPKM2L node 31

HUMPKM2L node 34

HUMPKM2L node 35

HUMPKM2L_ node 36

HUMPKM2L node 37

HUMPKM2L node 39 HUMPKM2L node 40

HUMPKM2L node 41

HUMPKM2L node 42

HUMPKM2L node 43

HUMPKM2L node 44

HUMPKM2L node 45

HUMPKM2L node 46

HUMPKM2L node 48

HUMPKM2L node 49

HUMPKM2L_ node -50

HUMPKM2L node 51

HUMPKM2L node 52

HUMPKM2L node 53

HUMPKM2L node 57

HUMPKM2L node 58

HUMPKM2L node 59

HUMPKM2L node 60

HUMPKM2L node 61

HUMPKM2L node 62

HUMPKM2L node 63

HUMPKM2L node 64

HUMPKM2L node 65

HUMPKM2L node 66

HUMPKM2L .node.. 67

HUMPKM2L node 68

HUMPKM2L node _69

HUMPKM2L node 70

HUMPKM2L node 71

HUMPKM2L node 72

HUMPKM2L node 75

HUMPKM2L node 76

HUMPKM2L node 77

HUMPKM2L node 80

HUMPKM2L node 81

HUMPKM2L node 82

HUMPKM2L node 83

HUMPKM2L node 84

HUMPKM2L node 85

HUMPKM2L node 93

HUMPKM2L node 94

HUMPKM2L node _95

HUMPKM2L node 96

HUMPKM2L node 97

HUMPKM2L node 98 HUMPKM2L node 99

HUMPKM2L node 100

HUMPKM2L node 101

HUMPKM2L node 102

HUMPKM2L node 103

HUMPKM2L node 106

HUMPKM2L node 107

HUMPKM2L node 108

HUMPKM2L node 109

HUMPKM2L_ node_ 110

HUMPKM2L node 112

HUMPKM2L node 113

HUMPKM2L node 114

HUMPKM2L node 115

HUMPKM2L node 116

HUMPKM2L node 117

HUMPKM2L node 118

HUMPKM2L node 119

HUMPKM2L node 120

HUMPKM2L node 121

HUMPKM2L node 122

HUMPKM2L node 123

HUMPKM2L node 124

HUMPKM2L node 125.

HUMPKM2L node 126

HUMPKM2L node J 27

HUMPKM2L node 128

HUMPKM2L node 129

HUMPKM2L node 130

HUMPKM2L node 131

HUMPKM2L node 132

HUMPKM2L node 133

HUMPKM2L node 134

HUMPKM2L node 135

HUMPKM2L node 136

HUMPKM2L node 137

HUMPKM2L node 138

HUMPKM2L node 139

HUMPKM2L node 140

HUMPKM2L node 141

HUMPKM2L node _142

HUMPKM2L node 143

HUMPKM2L node 144

HUMPKM2L node 145 HUMPKM2L node 146

HUMPKM2L node 147

HUMPKM2L node 148

HUMPKM2L node 149

HUMPKM2L node 150

HUMPKM2L node 151

Table 2850 - Proteins of interest

These sequences are variants of the known protein Pyruvate kinase, Ml isozyme (SwissProt accession identifier KPY1_HUMAN; known also according to the synonyms EC 2.7.1.40; Pyruvate kinase muscle isozyme; Cytosolic thyroid hormone-binding protein; CTHBP; THBPl), referred to herein as the previously known protein.

The sequence for protein Pyruvate kinase, Ml isozyme is given at the end of the application, as "Pyruvate kinase, M1 isozyme amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2851.

Table 2851 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: glycolysis, which are annotation(s) related to Biological Process; magnesium binding; pyruvate kinase; transferase, which are annotation(s) related to Molecular Function; and cytosol, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http ://www.ncbi.nlm.nih.gov/piOJects/LocusLink/>.

Cluster HUMPKM2L can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 75 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure_75.and- Table_2852. -This -cluster_is_overexpressed- (at Jeast-at-a-minimum level) in-the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues, hepatocellular carcinoma, malignant tumors involving the lymph nodes, ovarian carcinoma, pancreas carcinoma, gastric carcinoma and uterine malignancies.

Table 2852 - Normal tissue distribution

Table 2853 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMPKM2L features 120 segment(s), which were listed in Table

2849 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMPKM2L_node_2 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T27 and HUMPKM2L_T65. Table 2854 below describes the starting and ending position of this segment on each transcript.

Table 2854 - Segment location on transcripts

-This-segment- can be -found-in -a-non-coding-region of-transcript(s)-that-are-related-to the- following protein(s): HUMPKM2LJP10 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_3 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T27 and HUMPKM2L_T65. Table 2855 below describes the starting and ending position of this segment on each transcript.

Table 2855 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10 and HUMPKM2L_P37. Segment cluster HUMPKM2L_node_l 1 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6. Table 2856 below describes the starting and ending position of this segment on each transcript.

Table 2856 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4.

Segment cluster HUMPKM2L_node_12 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6. Table 2857 below describes the starting and ending position of this segment on each transcript.

Table 2857 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4.

Segment cluster HUMPKM2L_node_38 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T27. Table 2858 below describes the starting and ending position of this segment on each transcript.

Table 2858 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10.

Segment cluster HUMPKM2L_node_56 according to the present invention is supported by 3 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T41. Table 2859 below describes the starting and ending position of this segment on each transcript.

Table 2859 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_155 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment canT5e found irTthT following transcπpt^"(s)TΗUMPKM2irT65. TabIe^~28W below llesmtiesThe^" starting and ending position of this segment on each transcript.

Table 2860 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P37.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster HUMPKM2L_node_4 according to the present invention is supported by 177 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T27 and HUMPKM2L_T65. Table 2861 below describes the starting and ending position of this segment on each transcript.

Table 2861 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_10 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6. Table 2862 below describes the starting and ending position of this segment on each transcript.

T^e-28^~62^~Slϊgmeήflόcatϊblι on transcripts ^{~~ ~ ~™}

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4.

Segment cluster HUMPKM2L_node_14 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T9. Table 2863 below describes the starting and ending position of this segment on each transcript.

Table 2863 - Segment location on transcripts

HUMPKM2L T9 E 108

This segment can be found in the following protein(s): HUMPKM2L_P6.

Segment cluster HUMPKM2L_node_l 6 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6. Table 2864 below describes the starting and ending position of this segment on each transcript.

Table 2864 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4.

Segment cluster HUMPKM2L_node_J 9 according to the present invention is supported by 215 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2865 below describes the starting and ending position of this segment on each transcript.

Table 2865 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript. Segment cluster HUMPKM2L_node_20 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2866 below describes the starting and ending position of this segment on each transcript.

Table 2866 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10. This segment can also be found in the following protein(s): HUMPKM2L_P4, EDUMPKM2LJP6 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_21 according to the present invention is supported by 227 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2867 below describes the starting and ending position of this segment on each transcript.

Table 2867 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_22 according to the present invention is supported by 232 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2868 below describes the starting and ending position of this segment on each transcript.

Table 2868 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_23 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2869 below describes the starting and ending position of this segment on each transcript.

Table 2869 - Segment location on transcripts

I HUMPKM2L_T65 |_594 |J97 |

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_24 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2870 below describes the starting and ending position of this segment on each transcript.

Table 2870 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_25 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2871 below describes the starting and ending position of this segment on each transcript.

Table 2871 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_29 according to the present invention is supported by 215 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9,

HUMPKM2L_T27 and HUMPKM2L_T65. Table 2872 below describes the starting and ending position of this segment on each transcript.

Table 2872 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_30 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2LJT9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2873 below describes the starting and ending position of this segment on each transcript.

Table 2873 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_31 according to the present invention is supported by 248 libraries. The number of libraries was determined as previously described. This segment can be found^' in the following transcript(s): HUMPKM2L_T6, HUMPKM2ITT9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2874 below describes the starting and ending position of this segment on each transcript.

Table 2874 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript. Segment cluster HUMPKM2L_node_34 according to the present invention is supported by 273 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2875 below describes the starting and ending position of this segment on each transcript.

Table 2875 ~ Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcripts) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_35 according to the present invention is supported by 280 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2876 below describes the starting and ending position of this segment on each transcript. Table 2876 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_36 according to the present invention is supported by 281 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2877 below describes the starting and ending position of this segment on each transcript.

Table 2877 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_37 according to the present invention can be found in the following transcript(s): HUMPKM2L_T27. Table 2878 below describes the starting and ending position of this segment on each transcript.

Table 2878 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10.

Segment cluster HUMPKM2L_node_39 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2879 below describes the starting and ending position of this segment on each transcript.

Table 2879 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJ^>6 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_40 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2880 below describes the starting and ending position of this segment on each transcript.

Table 2880 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_41 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2881 below describes the starting and ending position of this segment on each transcript.

Table 2881 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_42 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2882 below describes the starting and ending position of this segment on each transcript.

Table 2882 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_43 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2883 below describes the starting and ending position of this segment on each transcript.

Table 2883 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P10. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_44 according to the present invention is supported by 305 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2884 below describes the starting and ending position of this segment on each transcript. 002438

1674

Table 2884 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_45 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2885 below describes the starting and ending position of this segment on each transcript.

Table 2885 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_46 according to the present invention can be found in the following transcript(s): HUMPKM2LJ6, HUMPKM2LJ9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2886 below describes the starting and ending position of this segment on each transcript.

Table 2886 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L P6, HUMPKM2L_P10 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_48 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2887 below describes the starting and ending position of this segment on each transcript.

Table 2887 - Segment location on transcripts

— This ""segment — can — be —found — in— the — following — protein(s)r — HUMPKM2L_P4,-

HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_49 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2888 below describes the starting and ending position of this segment on each transcript.

Table 2888 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_50 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2889 below describes the starting and ending position of this segment on each transcript.

Table 2889 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4,

HUMPKM2L P6, HUMPKM2LJP10 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_51 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2890 below describes the starting and ending position of this segment on each transcript.

Table 2890 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2LJP37. Segment cluster HUMPKM2L_node_52 according to the present invention is supported by 295 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T65. Table 2891 below descπbes the starting and ending position of this segment on each transcript.

Table 2891 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_53 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and

HUMPKM2L T65. Table 2892 below describes the starting and ending position of this segment on each transcript.

Table 2892 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_57 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2893 below describes the starting and ending position of this segment on each transcript.

Table 2893 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP16. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_58 according to the present invention can be found -in-the-followmg -transeript(s):— HUMPKM2L-T6— HUMPKM2LfT9_ϊ~HUMPKM2L__IT27,- HUMPKM2L_T41 and HUMPKM2L_T65. Table 2894 below describes the starting and ending position of this segment on each transcript.

Table 2894 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P16. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_59 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2895 below describes the starting and ending position of this segment on each transcript.

Table 2895 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following-protein(s)r-HUMPKM2L-P16r- This-segment-can- also-be-found in the— following- protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_60 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2896 below describes the starting and ending position of this segment on each transcript. Table 2896 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P16. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node 61 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2897 below describes the starting and ending position of this segment on each transcript.

Table 2897 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP16. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2L_P10 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_62 according to the present invention is supported by 291 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2898 below describes the starting and ending position of this segment on each transcript. Table 2898 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP16. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_63 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2899 below describes the starting and ending position of this segment on each transcript.

- Table-2899—Segment location on-transcripts-- — — — - — —

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): HUMPKM2L_P16. This segment can also be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10 and HUMPKM2L_P37, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPKM2L_node_64 according to the present invention is supported by 297 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2900 below describes the starting and ending position of this segment on each transcript.

Table 2900 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P16. This segment can also be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2LJP37, since it is in the coding region for the corresponding transcript.

Segment-cluster -HUMPKM2I_^node_65-according to the- present invention is supported - by 287 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2901 below describes the starting and ending position of this segment on each transcript.

Table 2901 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP10, HUMPKM2LJP16 and HUMPKM2LJP37. Segment cluster HUMPKM2L_node_66 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2902 below describes the starting and ending position of this segment on each transcript.

Table 2902 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2LJP10, HUMPKM2LJP16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_67 according to the present invention can be found -in— the— following— transcript(s):— HUMPKM2L;_T6,~ HUMPKM2L^T9,— HUMPKM2L_T27,- HUMPKM2L_T41 and HUMPKM2L_T65. Table 2903 below describes the starting and ending position of this segment on each transcript.

Table 2903 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10, HUMPKM2L_P16 and HUMPKM2L_P37. Segment cluster HUMPKM2L_node_68 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2904 below describes the starting and ending position of this segment on each transcript.

Table 2904 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10, HUMPKM2LJP16 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_69 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, -HUMPKM2L-T41-and HUMPKM2LjT65τ-Table 2905 below-descr-ibes the starting-and ending - position of this segment on each transcript.

Table 2905 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10, HUMPKM2L_P16 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_70 according to the present invention can be found in the following transcript(s): HUMPKM2L _T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2906 below describes the starting and ending position of this segment on each transcript.

Table 2906 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4,

HUMPKM2L_P6, HUMPKM2L_P10, HUMPKM2L_P16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_71 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2907 below describes the starting and ending position of this segment on each transcript.

Table 2907 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10, HUMPKM2L_P16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_72 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2908 below describes the starting and ending position of this segment on each transcript. Table 2908 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10, HUMPKM2LJP16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_75 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2909 below describes the starting and ending position of this segment on each transcript.

Table 2909 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L__P6, HUMPKM2L_P10, HUMPKM2LJP16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_76 according to the present invention is supported by 268 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2910 below describes the starting and ending position of this segment on each transcript.

Table 2910 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP10, HUMPKM2L_P16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_77 according to the present invention is supported by 306 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2911 below describes the starting and ending position of this segment on each transcript.

Table 2911 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10, HUMPKM2L_P16 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_80 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2912 below describes the starting and ending position of this segment on each transcript.

Table 2912 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2LJP10, HUMPKM2L_P16 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_81 according to the present invention can be found in the following transcript®: HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2913 below describes the starting and ending position of this segment on each transcript.

Table 2913 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10, HUMPKM2LJP16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_82 according to the present invention is supported by 308 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9,

HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2914 below describes the starting and ending position of this segment on each transcript.

Table 2914 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L P6, HUMPKM2LJP10, HUMPKM2L_P16 and HUMPKM2LJP37.

Segment cluster HUMPKM2L_node_83 according to the present invention can be found in the following transcript(s): HUMPKM2LJT6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2915 below describes the starting and ending position of this segment on each transcript.

Table 2915 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10, HUMPKM2LJP16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_84 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2916 below describes the starting and ending position of this segment on each transcript.

Table 2916 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2LJP10, HUMPKM2L_P16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_85 according to the present invention is supported by 329 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27, HUMPKM2L_T41 and HUMPKM2L_T65. Table 2917 below describes the starting and ending position of this segment on each transcript. Table 2917 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L P4, HUMPKM2LJP6, HUMPKM2L_P10, HUMPKM2L_P16 and HUMPKM2L_P37.

Segment cluster HUMPKM2L_node_93 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2918 below describes the starting and ending position of this segment on each transcript.

Table 2918 - Segment location on transcripts

HUMPKM2L T41 772 787

This segment can be found in the following protein(s): HUMPKM2LJM, HUMPKM2L P6, HUMPKM2L_P10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_94 according to the present invention can be found in tie following transcript(s): HUMPKM2LJ6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2919 below describes the starting and ending position of this segment on each transcript.

Table 2919 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HLJMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2LJP16.

Segment cluster HUMPKM2L_node_95 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2920 below describes the starting and ending position of this segment on each transcript.

Table 2920 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJM,

HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L_P16. Segment cluster HUMPKM2L_node_96 according to the present invention is supported by 322 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2921 below describes the starting and ending position of this segment on each transcript.

Table 2921 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L P16.

Segment cluster HUMPKM2L_node_97 according to the present invention can be found in tδe following transcΗpt^): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2922 below describes the starting and ending position of this segment on each transcript.

Table 2922 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_98 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2923 below describes the starting and ending position of this segment on each transcript.

Table 2923 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4,

HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_99 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2924 below describes the starting and ending position of this segment on each transcript.

Table 2924 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2L_P10 and HUMPKM2LJP16.

Segment cluster HUMPKM2L_node_100 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L__T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2925 below describes the starting and ending position of this segment on each transcript.

Table 2925 ~ Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_101 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2926 below describes the starting and ending position of this segment on each transcript.

Table 2926 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_102 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2927 below describes the starting and ending position of this segment on each transcript.

Table 2927 - Segment location on transcripts

HUMPKM2L T41 917 931

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2LJP16.

Segment cluster HUMPKM2L_node_l 03 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2928 below describes the starting and ending position of this segment on each transcript.

Table 2928 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L P4,

HUMPKM2L P6, HUMPKM2L PlO and HUMPKM2L P16.

Segment cluster HUMPKM2L_node_106 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2LJT27 and HUMPKM2L_T41. Table 2929 below describes the starting and ending position of this segment on each transcript.

Table 2929 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2LJP16. Segment cluster HUMPKM2L_node_107 according to the present invention is supported by 384 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2930 below describes the starting and ending position of this segment on each transcript.

Table 2930 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_108 according to the present invention is supported by 384 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2931 below describes the starting and ending position of this segment on each transcript.

Table 2931 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10 and HUMPKM2L_P16. Segment cluster HUMPKM2L_node_109 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2932 below describes the starting and ending position of this segment on each transcript.

Table 2932 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_110 according to the present invention is supported by 382 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L T9, HUMPKM2L_T27 andlHUMPKM2L^^ position of this segment on each transcript. Table 2933 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_112 according to the present invention is supported by 311 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2934 below describes the starting and ending position of this segment on each transcript.

Table 2934 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4,

HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_113 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2935 below describes the starting and ending position of this segment on each transcript.

Table 2935 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2LJP16.

Segment cluster HUMPKM2L_node_l 14 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L T41. Table 2936 below describes the starting and ending position of this segment on each transcript.

Table 2936 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_115 according to the present invention is supported by 306 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2LJ27 and HUMPKM2L_T41. Table 2937 below describes the starting and ending position of this segment on each transcript. Table 2937 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPKM2LJP4, HUMPKM2L P6, HUMPKM2L_P10 and HUMPKM2L P16.

Segment cluster HUMPKM2L_node_116 according to the present invention is supported by 281 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2938 below describes the starting and ending position of this segment on each transcript. Table 2938 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_l 17 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2939 below describes the starting and ending position of this segment on each transcript. Table 2939 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_l 18 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2940 below describes the starting and ending position of this segment on each transcript.

Table 2940 - Segment location on transcripts

Tins segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJM, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L P16.

Segment cluster HUMPKM2L_node_l 19 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2941 below describes the starting and ending position of this segment on each transcript.

Table 2941 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_120 according to the present invention can be found in the following transcript(s): HUMPKM2L__T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2942 below describes the starting and ending position of this segment on each transcript. Table 2942 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJM0 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_121 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L J27 and HUMPKM2L_T41. Table 2943 below describes the starting and ending position of this segment on each transcript. Table 2943 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the HUMPKM2LJP16.

Segment cluster HUMPKM2L_node_122 according to the present invention is supported by 303 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2944 below describes the starting and ending position of this segment on each transcript.

Table 2944 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protem(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP 10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_123 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2945 below describes the starting and ending position of this segment on each transcript.

Table 2945 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2LT^>T6.^{~ " " ~ ~ ~ ' ~}

Segment cluster HUMPKM2L_node_124 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2946 below describes the starting and ending position of this segment on each transcript.

Table 2946 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_125 according to the present invention can be found in the following transcript(s): HUMPKM2LJ6, HUMPKM2LJ9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2947 below describes the starting and ending position of this segment on each transcript.

Table 2947 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2LJP10 and

HUMPKM2L P16.

Segment cluster HUMPKM2L_node_126 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2948 below describes the starting and ending position of this segment on each transcript.

Table 2948 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_127 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2949 below describes the starting and ending position of this segment on each transcript.

Table 2949 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10 and

HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_128 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2950 below describes the starting and ending position of this segment on each transcript.

Table 2950 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_129 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2951 below describes the starting and ending position of this segment on each transcript.

Table 2951 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2L_P10 and

HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_130 according to the present invention is supported by 296 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2952 below describes the starting and ending position of this segment on each transcript. Table 2952 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L P16.

Segment cluster HUMPKM2L_node_131 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2953 below describes the starting and ending position of this segment on each transcript.

Table 2953 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10 and

HUMPKM2L P16.

Segment cluster HUMPKM2L_node_132 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2954 below describes the starting and ending position of this segment on each transcript.

Table 2954 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2LJP 10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_133 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2955 below describes the starting and ending position of this segment on each transcript.

Table 2955 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP10 and

HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_134 according to the present invention is supported by 274 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2956 below describes the starting and ending position of this segment on each transcript. Table 2956 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_135 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2LJ27 and HUMPKM2L_T41. Table 2957 below describes the starting and ending position of this segment on each transcript.

Table 2957 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10 and

^"HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_136 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2958 below describes the starting and ending position of this segment on each transcript.

Table 2958 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_l 37 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2959 below describes the starting and ending position of this segment on each transcript.

Table 2959 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2LJP10 and ^~HUMPKM2L^~PΪ6. ^{~ ~~ ~~ "}

Segment cluster HUMPKM2L_node_138 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2960 below describes the starting and ending position of this segment on each transcript.

Table 2960 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_l 39 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2961 below describes the starting and ending position of this segment on each transcript.

Table 2961 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10 and

IUMPKM2L P 16.

Segment cluster HUMPKM2L_node_140 according to the present invention is supported by 230 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2962 below describes the starting and ending position of this segment on each transcript. Table 2962 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_141 according to the present invention is supported by 192 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2963 below describes the starting and ending position of this segment on each transcript.

Table 2963 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following proteln(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2L_P10 and^" HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_142 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2964 below describes the starting and ending position of this segment on each transcript.

Table 2964 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L Pl 6.

Segment cluster HUMPKM2L_node_143 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2965 below describes the starting and ending position of this segment on each transcript.

Table 2965 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2LJP6, HUMPKM2LJP10 and ΕUMPKM2Γ P 16. ^{" ~ ~~~ ~ " " " ~ ~~~~}

Segment cluster HUMPKM2L_node_144 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2966 below describes the starting and ending position of this segment on each transcript.

Table 2966 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L Pl 6.

Segment cluster HUMPKM2L_node_145 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2967 below describes the starting and ending position of this segment on each transcript.

Table 2967 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and

HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_146 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L T41. Table 2968 below describes the starting and ending position of this segment on each transcript.

Table 2968 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L P16.

Segment cluster HUMPKM2L_node_147 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2969 below describes the starting and ending position of this segment on each transcript.

Table 2969 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10 and

HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_148 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2970 below describes the starting and ending position of this segment on each transcript.

Table 2970 - Segment location on transcripts

This segment can be found in a non-codmg region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L P 16.

Segment cluster HUMPKM2L_node_149 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2971 below describes the starting and ending position of this segment on each transcript.

Table 2971 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2L_P4, HUMPKM2L_P6, HUMPKM2LJP10 and

HUMPKM2L P16.

Segment cluster HUMPKM2L_node_150 according to the present invention can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2972 below describes the starting and ending position of this segment on each transcript.

Table 2972 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2L_P6, HUMPKM2L_P10 and HUMPKM2L_P16.

Segment cluster HUMPKM2L_node_151 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPKM2L_T6, HUMPKM2L_T9, HUMPKM2L_T27 and HUMPKM2L_T41. Table 2973 below describes the starting and ending position of this segment on each transcript.

Table 2973 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPKM2LJP4, HUMPKM2LJP6, HUMPKM2LJP10 and HUMPKM2L_P16.

DESCRIPTION FOR CLUSTER HUMPROTP

Cluster HUMPROTP features 20 transcript(s) and 33 segment(s) of interest, the names for which are given in Tables 2974 and 2975, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 2976.

Table 2974 - Transcripts of interest

Transcript Name

HUMPROTP TO

HUMPROTP Tl

HUMPROTP T2

HUMPROTP T3 HUMPROTP T4

HUMPROTP T5

HUMPROTP T6

HUMPROTP T7

HUMPROTP T8

HUMPROTP T9

HUMPROTP TlO

HUMPROTP TI l

HUMPROTP T12

HUMPR0TP_ _T14

HUMPROTP T15

HUMPROTP T16

HUMPROTP T17

HUMPROTP T18

HUMPROTP T19

HUMPROTP T20

Table 2975 - Segments of interest

Segment Name ;

HUMPROTP node O

HUMPROTP node 2

HUMPROTP node 5

HUMPROTP node

HUMPROTP node 9

HUMPROTP node 11

HUMPROTP node 14

HUMPROTP node 16

HUMPROTP node 23

HUMPROTP node 29

HUMPROTP node 31

HUMPROTP node 32

HUMPROTP node 33

HUMPROTP _node_ _38

HUMPROTP node 46

HUMPROTP node 48

HUMPROTP node 50

HUMPROTP node 51

HUMPROTP node 12

HUMPROTP node 17

HUMPROTP node 19

HUMPROTP node 21

HUMPROTP node 25

HUMPROTP node 26 HUMPROTP node 28

HUMPROTP node 30

HUMPROTP node 34

HUMPROTP node 36

HUMPROTP node 37

HUMPROTP node 39

HUMPROTP node 41

HUMPROTP node 43

HUMPROTP node 44

Table 2976 - Proteins of interest

These sequences are variants of the known protein Vacuolar ATP synthase subunit B, kidney isoform (SwissProt accession identifier VAB1_HUMAN; known also according to the synonyms EC 3.6.3.14; V- ATPase Bl subunit; Vacuolar proton pump B isoform 1; Endomembrane proton pump 58 kDa subunit), referred to herein as the previously known protein.

Protein Vacuolar ATP synthase subunit B, kidney isoform is known or believed to have the following function(s): Noncatalytic subunit of the peripheral Vl complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The sequence for protein Vacuolar ATP synthase subunit B, kidney isoform is given at the end of the application, as "Vacuolar ATP synthase subunit B, kidney isoform amino acid sequence". Known polymorphisms for this sequence are as shown in Table 2977. Table 2977 - Amino acid mutations for Known Protein

Protein Vacuolar ATP synthase subunit B, kidney isoform localization is believed to be Endomembrane.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: ATP biosynthesis; excretion; hearing; energy coupled proton transport, against the electrochemical gradient; proton transport, which are annotation(s) related to Biological Process; ATP -binding and phosphorylation-dependent chloride channel; ATP binding; hydrogen- exporting ATPase; hydrolase, which are annotation(s) related to Molecular Function; and cytoplasm; plasma membrane; hydrogen-transporting two-sector ATPase, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

As noted above, cluster HUMPROTP features 33 segment(s), which were listed in Table

2975 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster HUMPROTP_node_0 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP TO, HUMPROTP_Tl, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_T11,

HUMPROTP_T12, HUMPROTP_T14, HUMPROTP_T15 and HUMPROTP_T16. Table 2978 below describes the starting and ending position of this segment on each transcript.

Table 2978 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P2, HUMPROTP_P6, HUMPROTP_P7 and HUMPROTP_P8.

Segment cluster HUMPROTP_node_2 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T6 and HUMPR0TP_T8. Table 2979 below describes the starting and ending position of this segment on each transcript.

Table 2979 - Segment location on transcripts

This segment can be found in a non-coding region of transcπpt(s) that are related to the following protein(s): HUMPROTP_P3 and HUMPROTP_P5.

Segment cluster HUMPROTP_node_5 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP T7. Table 2980 below describes the starting and ending position of this segment on each transcript.

Table 2980 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3.

Segment cluster HUMPROTP_node_7 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can tJFfdund in^~the iδllow^'ingTrarisCTiptCsOrΗXJMPROTP^δ^MTTϋMPROTP TδrTable 2981^" below describes the starting and ending position of this segment on each transcript.

Table 2981 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3 and HUMPROTP_P5.

Segment cluster HUMPRO TP_node_9 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T6 and HUMPROTP_T8. Table 2982 below describes the starting and ending position of this segment on each transcript. Table 2982 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3 and HUMPROTP_P5.

Segment cluster HUMPROTP_node_l 1 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T5. Table 2983 below describes the starting and ending position of this segment on each transcript.

Table 2983 - Segment location on transcripts

^"Tvficroarray (chip) data is also available for tlfis segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 2984.

Table 2984 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMPROTP_P4.

Segment cluster HUMPROTP_node_14 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T8. Table 2985 below describes the starting and ending position of this segment on each transcript. Table 2985 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPROTP_P5.

Segment cluster HUMPROTP_node_l 6 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T4. Table 2986 below describes the starting and ending position of this segment on each transcript.

Table 2986 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3.

Segment cluster HUMPROTP_node_23 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T0, HUMPROTP_Tl,

HUMPROTP_T2, HUMPROTP_T3, HUMPROTP T4, HUMPROTP T5, HUMPROTP_T6,

HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_T11,

HUMPROTP_T12, HUMPROTP_T14, HUMPROTP_T15 and HUMPROTP_T16. Table 2987 below describes the starting and ending position of this segment on each transcript.

Table 2987 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3. This segment can also be found^" in the ^"following^" protein(s): HUMPROTP_P11, HUMPROTP_P2, HUMPR0TPJP4, HUMPR0TP_P5, HUMPR0TP P6, HUMPROTP_P7 and HUMPROTP_P8, since it is in the coding region for the corresponding transcript.

Segment-cluster-HUMPROTP_node_z:29-accordmg to -the- present- invention- is supported - by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_Tl, HUMPR0TP_T2, HUMPROTP T3, HUMPROTP_T4, HUMPROTP_T5, HUMPR0TP_T6, HUMPR0TP_T7, HUMPROTP_T10, HUMPROTP_Tl l, HUMPROTP_T14 and HUMPROTP_T16. Table 2988 below describes the starting and ending position of this segment on each transcript. Table 2988 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPR0TP_P3. This segment can also be found in the following protein(s): HUMPROTPJP2 and HUMPR0TP_P4, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_31 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in^" the following transcript(s): -HUMPROTP T-I-, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T10, HUMPROTPjri l, HUMPROTP_T14 and HUMPROTP_T16. Table 2989 below describes the starting and ending position of this segment on each transcript.

Table 2989 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2, HUMPROTP_P3 and HUMPR0TP_P4.

Segment cluster HUMPROTP_node_32 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T1, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T10, HUMPROTP_T11 and HUMPROTP_T14. Table 2990 below describes the starting and ending position of this segment on each transcript.

Table 2990 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2, HUMPROTP_P3 and HUMPROTP_P4.

Segment cluster HUMPROTP_node_33 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T0, HUMPROTP_T1, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPR0TP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_T11, HUMPROTPjm, HUMPROTP_T14 and HUMPROTP_T15. Table 2991 below describes the starting and ending position of this segment on each transcript.

Table 2991 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2, HUMPROTP_P3 and HUMPROTP_P4. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P5, HUMPROTP P6, HUMPROTP_P7 and HUMPROTP_P8, since i is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_38 according to the present invention is supported ^~ by^~2 librafiesTThe^~ήύmbef σf libraries^" was^" determined as previoϋslyHescπbed.^~This segment^" can be found in the fcllowing transcript(s): HUMPROTP_TIO. Table 2992 below describes the starting and ending position of this segment on each transcript.

Table 2992 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2.

Segment cluster HUMPROTP_node_46 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T18 and HUMPROTP_T20. Table 2993 below describes the starting and ending position of this segment on each transcript. Table 2993 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P10.

Segment cluster HUMPROTP_node_48 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T0, HUMPROTP_T1, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPR0TP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_Tl l, HUMPROTP_T12, HUMPROTP_T17, HUMPROTP_T18, HUMPROTP _Tl 9 and HUMPROTP_T20. Table 2994 below describes the starting and ending position of this segment on each transcript.

Table 2994 - Segmenilocation on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2, HUMPROTP_P4, HUMPROTP_P5, HUMPROTP P6 and HUMPROTP_P7. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P3, HUMPROTP_P9 and HUMPROTP_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_50 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_TO, HUMPROTP_Tl,

HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6,

HUMPROTP_T7, HUMPROTP_T8, HUMPROTP T9, HUMPROTP_T10, HUMPROTP_Tl l,

HUMPROTP T 12, HUMPROTP_T17, HUMPROTP T 18, HUMPROTP T 19 and HUMPROTP_T20. Table 2995 below describes the starting and ending position of this segment on each transcript. Table2995 - Segment location on .transcripts. .

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2, HUMPROTP_P4, HUMPROTP JP5, HUMPROTP P6 and HUMPROTP_P7. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P3, HUMPROTP_P9 and HUMPROTP_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP node_51 according to the present ήvention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_TO, HUMPROTP_Tl,

HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6,

HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP JIO, HUMPROTP_Tl l,

HUMPROTP_T12, HUMPROTP_T16, HUMPROTP_T17, HUMPROTP_T18, HUMPROTP_T19 and HUMPROTP_T20. Table 2996 below describes the starting and ending position of this segment on each transcript.

Table 2996 - Segment-location on transcripts _

HUMPROTP T20 641 1420

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P11, HUMPROTP_P2, HUMPROTP_P3, HUMPROTP_P4, HUMPROTP_P5, HUMPROTP_P6, HUMPROTP_P7, HUMPROTP_P9 and HUMPROTP PlO.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMPROTP_node_12 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_TO, HUMPROTP_T1, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP T8, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_T11,

HUMPROTP_T12, HUMPROTPjri4, HUMPROTP_T15 and HUMPROTP_T16. Table 2997 below describes the starting and ending position of this segment on each transcript.

Table 2997 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be fcund in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3 and HUMPROTP_P5. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P2, HUMPROTP_P4, HUMPROTPJP6, HUMPROTP_P7 and HUMPROTP P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_17 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP TO, HUMPROTP_Tl,

HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6,

HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_Tl l,

HUMPROTP_T12, HUMPROTP_T14, HUMPROTP_T15 and HUMPROTP_T16. Table 2998 below describes the starting and ending position of this segment on each transcript.

Table 2998 - Segmetiflocatioή^~on Transcripts ^{~ ~~ "}

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3. This segment can also be found in the following protein(s): HUMPROTPJPl l , HUMPROTP JP2, HUMPROTP P4, HUMPROTP P5, HUMPROTP_P6, HUMPROTPJP7 and HUMPROTP_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_19 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP TO, HUMPROTP_T1,

HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6,

HUMPROTP_T7, HUMPROTP_T8, HUMPROTP T9, HUMPROTP _TlO, HUMPROTP_T11,

HUMPROTP_T12, HUMPROTP_T14, HUMPROTP_T15 and HUMPROTP_T16. Table 2999 below describes the starting and ending position of this segment on each transcript.

Table 2999 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P2, HUMPROTP_P4, HUMPROTP J?5, HUMPROTP_P6, HUMPROTP_P7 and HUMPROTP_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_21 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP TO, HUMPROTP_Tl, HUMPROTP_T2, HUMPROTP _T3, HUMPROTP _T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP T8, HUMPROTP_T9, HUMPROTP_TIO, HUMPROTP_T11, HUMPROTP_T12, HUMPROTP_T14, HUMPROTP_T15 and HUMPROTP T16. Table 3000 below describes the starting and ending position of this segment on each transcript.

Table 3000 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P2, HUMPROTP_P4, HUMPROTP_P5, HUMPROTP_P6, HUMPROTP_P7 and HUMPROTP_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_25 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T0, HUMPROTP T1, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_T11, HUMPROTP_T12, HUMPROTP_T14, HUMPROTP_T15 and HUMPROTP_T16. Table 3001 below describes the starting and ending position of this segment on each transcript.

Table 3001 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 3002. Table 3002 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P3. This segment can also be found in the following protein(s): HUMPROTPJPl l, HUMPROTP_P2, HUMPROTP_P4, HUMPROTP_P5, HUMPROTP_P6, HUMPROTP_P7 and HUMPROTP_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_26 according to the present invention can be found in the following transcript(s): HUMPROTP_T9. Table 3003 below describes the starting and ending position of this segment on each transcript.

Table 3003 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPROTP_P6.

Segment cluster HUMPROTP_node_28 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTPJTO, HUMPROTP_Tl, HUMPROTPJT2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_Tll, HUMPROTP_T12, HUMPROTP_T14, HUMPROTP_T15 and HUMPROTP_T16. Table 3004 below describes the starting and ending position of this segment on each transcript.

Table 3004 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPR0TP P3. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P2, HUMPROTP_P4, HUMPROTP_P5, HUMPROTPJP6, HUMPROTP_P7 and HUMPROTP_P8, since it is in the coding region for -the-corresponding -transcript. — — — — —

Segment cluster HUMPROTP_node_30 according to the present invention can be found in the following transcript(s): HUMPROTP_Tl, HUMPR0TP T3, HUMPROTP_T4,

HUMPR0TP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T IO, HUMPROTP_T11 and HUMPR0TP_T14. Table 3005 below describes the starting and ending position of this segment on each transcript.

Table 3005 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2, HUMPROTP_P3 and HUMPROTP_P4.

Segment cluster HUMPROTP_node_34 according to the present invention can be found in the following transcript(s): HUMPROTP_T14 and HUMPROTP_T15. Table 3006 below describes the starting and ending position of this segment on each transcript.

Table 3006 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2. This segment can also be found in the following protein(s): HUMPROTP P8, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_36 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T0, HUMPROTP_T1, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_TIO and HUMPROTP_Tl 1. Table 3007 below describes the starting and ending position of this segment on each transcript.

Table 3007 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2, HUMPROTP_P3 and HUMPROTP_P4. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P5 and HUMPROTP P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_37 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T0, HUMPROTP_Tl, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_TIO and HUMPROTP_T11. Table 3008 below describes the starting and ending position of this segment on each transcript.

Table 3008 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2 and HUMPROTP_P4. This segment can also be found in the following protein(s): HUMPROTPJP11, HUMPROTP_P3, HUMPROTP_P5 and HUMPROTP_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP_node_39 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_T0, HUMPROTP_Tl, HUMPROTP_T2, HUMPROTP T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP_T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP _TlO, HUMPROTP_T11 and HUMPROTP_T12. Table 3009 below describes the starting and ending position of this segment on each transcript. Table 3009 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2 and HUMPROTPJP4. This segment can also be found in the following protein(s): HUMPROTPJP1 1, HUMPROTP_P3, HUMPROTP J?5, HUMPROTP_P6 and HUMPROTP_P7, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPROTP node_41 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP T11. Table 3010 below describes the starting and ending position of this segment on each transcript.

Table 3010 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPROTPJP2.

Segment cluster HUMPROTP_node_43 according to the present invention is supported by^" FlibrafiesTThe riύmFeFof lbraries^"was^~deTermined ^"as previόTisly^es^πbedrThis^{^}segmerir can be found in the following transcript(s): HUMPROTP_T17 and HUMPROTP_T19. Table 3011 below describes the starting and ending position of this segment on each transcript.

Table 3011 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPROTP_P9.

Segment cluster HUMPROTP_node_44 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPROTP_TO, HUMPROTP_Tl, HUMPROTP_T2, HUMPROTP_T3, HUMPROTP_T4, HUMPROTP_T5, HUMPROTP_T6, HUMPROTP T7, HUMPROTP_T8, HUMPROTP_T9, HUMPROTP_T10, HUMPROTP_T11, HUMPROTP_T12, HUMPROTP_T17 and HUMPROTP_T19. Table 3012 below describes the starting and ending position of this segment on each transcript.

Table 3012 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPROTP_P2, HUMPROTP_P4, HUMPROTP_P5, HUMPROTP_P6 and HUMPROTP_P7. This segment can also be found in the following protein(s): HUMPROTP_P11, HUMPROTP_P3 and HUMPROTP_P9, since it is in the coding region for the corresponding transcript. DESCRIPTION FOR CLUSTER HUMSTPK13

Cluster HUMSTPKl 3 features 7 transcript(s) and 27 segment(s) of interest, the names for which are given in Tables 3013 and 3014, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3015.

Table 3013 - Transcripts of interest Transcript Name

HUMSTPKl 3 T2

HUMSTPKl 3 T4

HUMSTPK13 T7

HUMSTPKl 3 T8

HUMSTPK13 T12

HUMSTPK13 T15

HUMSTPKl 3 T16

Table 3014 - Segments of interest

Segment Name

HUMSTPKl 3 node 6

HUMSTPKl 3 node 7

HUMSTPKl 3 node 11

HUMSTPKl 3 node 12

HUMSTPKl 3 node 14

HUMSTPKl 3 node 22

HUMSTPKl 3 node 27

HUMSTPK13 node 32

HUMSTPK13 node 33

HUMSTPKl 3 node 35

HUMSTPK13 node 39

HUMSTPKl 3 node 42

HUMSTPK13 node 1

HUMSTPKl 3 node 2

HUMSTPKl 3 node 3

HUMSTPKl 3 node 5

HUMSTPK13 node 9

HUMSTPK13 node 18

HUMSTPKl 3 node 23

HUMSTPKl 3 node 30

HUMSTPK13 node 31

HUMSTPKl 3 node 34

HUMSTPK13 node 36

HUMSTPK13 node 37

HUMSTPKl 3 node 38

HUMSTPKl 3 node 40

HUMSTPKl 3 node 43

Table 3015 - Proteins of interest

These sequences are variants of the known protein Serine/threonine-protein kinase PLK (SwissProt accession identifier PLKl-HUMAN; known also according to the synonyms EC 2.7.1.-; PLK-I; Serine- threonine protein kinase 13; STPK13), referred to herein as the previously known protein.

Protein Serine/threonine-protein kinase PLK is known or believed to have the following function(s): May be required for cell division and may have a role during Gl or S phase. The sequence for protein Serine/threonine-protein kinase PLK is given at the end of the application, as "Serine/threonine-protein kinase PLK amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3016.

Table 3016 - Amino acid mutations for Known Protein

Protein Serine/threonine-protein kinase PLK localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell cycle control; protein amino acid phosphorylation; mitosis; cell proliferation, which are annotation(s) related to Biological Process; protein serine/threonine kinase; ATP binding; transferase, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nkn.nih.gov/projects/LocusLink/>.

Cluster HUMSTPKl 3 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 76 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 76 and Table 3017. This cluster is overexpressed (at least at a minimum level) in the following pathological- conditions: -epithelial malignant tumors, a mixture- of malignant tumors - from different tissues, hepatocellular carcinoma, lung malignant tumors, myosarcoma, pancreas carcinoma, skin malignancies and uterine malignancies. Table 3017 - Normal tissue distribution

Table 3018 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMSTPKl 3 features 27 segment(s), which were listed in Table 3014 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMSTPKl 3_node_6 according to the present invention is supported by 101 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4, HUMSTPK13_T7, HUMSTPK13_T8 and HUMSTPK13_T12. Table 3019 below describes the starting and ending position of this segment on each transcript.

Table 3019 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as -follows. The segment can-be-found-in a non-coding-region of transcript(s) that are related to the- following protein(s): HUMSTPK13_P9. This segment can also be found in the following protein(s): HUMSTPK13_P2, HUMSTPK13_P4, HUMSTPK13_P6 and HUMSTPK13_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPKl 3_node_7 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T12. Table 3020 below describes the starting and ending position of this segment on each transcript.

Table 3020 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPK13_P9.

Segment cluster HUMSTPK 13_node_l l according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcripts): HUMSTPKl 3_T15. Table 3021 below describes the starting and ending position of this segment on each transcript.

Table 3021 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P9.

Segment cluster HUMSTPKl 3_node_l 2 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can^~ be^~~found^"iri^~~the follόwirlg^~~&anscript(s): HUMSTPKT3_T2; HUMSTPK13_T4r HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPK13_T12, HUMSTPK13_T15 and HUMSTPKl 3_T 16. Table 3022 below describes the starting and ending position of this segment on each transcript.

Table 3022 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P9. This segment can also be found in the following protein(s): HUMSTPKl 3_P2, HUMSTPKl 3_P4, HUMSTPKl 3_P6 and HUMSTPKl 3_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPK13_node_14 according to the present invention is supported by 97 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPK13_T12, HUMSTPK13_T15 and HUMSTPK13_T16. Table 3023 below describes the starting and ending position of this segment on each transcript.

Table 3023 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPK13_P2, HUMSTPKl 3_P4, HUMSTPKl 3_P6, HUMSTPKl 3_P5 and HUMSTPKl 3_P9.

Segment cluster HUMSTPKl 3_node_22 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T2, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPK13_T12, HUMSTPK13_T15 and HUMSTPKl 3_T16. Table 3024 below describes the starting and ending position of this segment on each transcript.

Table 3024 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPKl 3_P2, HUMSTPKl 3JP6, HUMSTPKl 3 JP5 and HUMSTPKl 3_P9.

Segment cluster HUMSTPKl 3_node_27 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T2, HUMSTPK13_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPK13_T12, HUMSTPK13_T15 and HUMSTPKl 3_T 16. Table 3025 below describes the starting and ending position of this segment on each transcript.

Table 3025 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPKl 3_P2, HUMSTPKl 3_P4, HUMSTPKl 3_P6, HUMSTPKl 3_P5 and HUMSTPKl 3_P9.

Segment cluster HUMSTPKl 3_node_32 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T2. Table 3026 below describes the starting and ending position of this segment on each transcript.

Table 3026 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPKl 3_P2.

Segment cluster HUMSTPK 13_node_33 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPKl 3_T 12, HUMSTPK13_T 15 and HUMSTPKl 3_T 16. Table 3027 below describes the starting and ending position of this segment on each transcript.

Table 3027 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P2. This segment can also be found in the following protein(s): HUMSTPK13_P4, HUMSTPK13_P6, HUMSTPK13_P5 and HUMSTPK13_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPKl 3_node_35 according to the present invention is supported by 118 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T2, HUMSTPK13_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPK13_T12, HUMSTPK13_T15 and HUMSTPKl 3_T 16. Table 3028 below describes the starting and ending position of this segment on each transcript.

Table 3028 - Segment location on transcripts

This segment can be found in both coding and no n- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPK13_P2 and HUMSTPK13_P4. This segment can also be found in the following protein(s): HUMSTPK13_P6, HUMSTPK13_P5 and HUMSTPK13_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPKl 3_node_39 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPKl 3_T12, HUMSTPK13_T15 and HUMSTPKl 3_T 16. Table 3029 below describes the starting and ending position of this segment on each transcript.

Table 3029 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPK13_P2, HUMSTPK13_P4, HUMSTPK13_P6 and HUMSTPK13_P5. This segment can also be found in the following protein(s): HUMSTPKl 3JP9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPKl 3_node_42 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPKl 3_T 12, HUMSTPK13_T15 and HUMSTPK13 T16. Table 3030 below describes the starting and ending position of this segment on each transcript.

Table 3030 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPK13_P2, HUMSTPK13_P4, HUMSTPK13_P6, HUMSTPK13 P5 and HUMSTPK13 P9.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster HUMSTPKl 3_node_l according to the present invention is supported by 51 libraries. The number of libraries was determined as previously descπbed. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4, HUMSTPK13_T7, HUMSTPK13_T8 and HUMSTPKl 3_T12. Table 3031 below describes the starting and ending position of this segment on each transcript.

Table 3031 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P2, HUMSTPKl 3_P6, HUMSTPKl 3_P5 and HUMSTPKl 3_P9. This segment can also be found in the following protein(s): HUMSTPK-13JMj-since it-is in the coding-region-for the-corresponding-transcript: — —

Segment cluster HUMSTPKl 3_node_2 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4,

HUMSTPK13_T7, HUMSTPK13_T8 and HUMSTPKl 3_T 12. Table 3032 below describes the starting and ending position of this segment on each transcript.

Table 3032 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P9. This segment can also be found in the following protein(s): HUMSTPKl 3_P2, HUMSTPKl 3_P4, HUMSTPKl 3_P6 and HUMSTPKl 3_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPKl 3_node_3 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4, HUMSTPK13_T7, HUMSTPK13_T8 and HUMSTPK13_T12. Table 3033 below describes the starting and ending position of this segment on each transcript.

Table 3033 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P9. This segment can also be found in the following protein(s): HUMSTPK13_P2, HUMSTPK13_P4, HUMSTPK13_P6 and HUMSTPK13_P5, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPKl 3_node_5 according to the present invention is supported by

95 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T2, HUMSTPK13_T4, HUMSTPKl 3_T7, HUMSTPK13_T8 and HUMSTPKl 3_T12. Table 3034 below describes the starting and ending position of this segment on each transcript. Table 3034 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P9. This segment can also be found in the following protein(s): HUMSTPK13_P2, HUMSTPK13_P4, HUMSTPK13_P6 and HUMSTPK13JP5, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPKl 3_node_9 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T16. Table 3035 below describes the starting and ending position of this segment on each transcript. Table 303-5 — Segment location-on transcripts ^■

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P9.

Segment cluster HUMSTPKl 3_node_l 8 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T2, HUMSTPK13_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPKl 3_T12, HUMSTPK13_T15 and HUMSTPKl 3_T 16. Table 3036 below describes the starting and ending position of this segment on each transcript.

Table 3036 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPKl 3_P2, HUMSTPKl 3_P4, HUMSTPKl 3_P6, HUMSTPKl 3_P5 and HUMSTPKl 3_P9.

Segment cluster HUMSTPKl 3_node_23 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T2, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPKl 3_T12, HUMSTPK13_T15 and HUMSTPKl 3_T16. Table 3037 below describes the starting and ending position of this segment on each transcript. Table 3037 ~ Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPK13_P2, HUMSTPKl 3 P6, HUMSTPKl 3 P5 and HUMSTPKl 3_P9.

Segment cluster HUMSTPKl 3_node_30 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T2, HUMSTPK13_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPK13_T12, HUMSTPK13_T15 and HUMSTPKl 3_T16. Table 3038 below describes the starting and ending position of this segment on each transcript.

Table 3038 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPKl 3_P2,

HUMSTPKl 3_P4, HUMSTPKl 3_P6, HUMSTPKl 3_P5 and HUMSTPKl 3_P9.

Segment cluster HUMSTPKl 3_node_31 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4,

HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPK13_T12, HUMSTPK13_T15 and HUMSTPK13_T16. Table 3039 below describes the starting and ending position of this segment on each transcript.

Table 3039 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPKl 3_P2, HUMSTPK13_P4, HUMSTPK13_P6, HUMSTPK13_P5 and HUMSTPK13JP9. Segment cluster HUMSTPK 13_node_34 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T7. Table 3040 below describes the starting and ending position of this segment on each transcript.

Table 3040 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPKl 3_P6.

Segment cluster HUMSTPKl 3_node_36 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPK13_T4, HUMSTPK13_T7, HUMSTPK13 T8, HUMSTPKl 3_T 12, HUMSTPK13_T15 and HUMSTPKl 3_T16. Table 3041 below describes the starting and ending position of this segment on each transcript. Table 3041 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPK13_P2, HUMSTPK13_P4 and HUMSTPK13_P6. This segment can also be found in the following protein(s): HUMSTPKl 3_P5 and

HUMSTPKl 3JP9, since it is in the coding region for the corresponding transcript. Segment cluster HUMSTPKl 3_node_37 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3__T8. Table 3042 below describes the starting and ending position of this segment on each transcript.

Table 3042 - Segment location on transcripts

This segment can be found in the following protein(s): HUMSTPK13_P5.

Segment cluster HUMSTPKl 3_node_38 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPK13_T8. Table 3043 below describes the starting and ending position of this segment on each transcript.

Table 3043 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPK13_P5.

Segment cluster HUMSTPKl 3_node_40 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4, HUMSTPK13_T7, HUMSTPK13_T8, HUMSTPK13_T12, HUMSTPK13_T15 and HUMSTPKl 3_T16. Table 3044 below describes the starting and ending position of this segment on each transcript.

Table 3044 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPKl 3_P2, HUMSTPKl 3_P4, HUMSTPKl 3_P6 and HUMSTPK13_P5. This segment can also be found in the following protein(s):

HUMSTPKl 3_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMSTPKl 3_node_43 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMSTPKl 3_T2, HUMSTPKl 3_T4,

HUMSTPKl 3_T7, HUMSTPKl 3_T8, HUMSTPKl 3_T12, HUMSTPKl 3_T15 and

HUMSTPKl 3_T 16. Table 3045 below describes the starting and ending position of this segment on each transcript.

Table 3045 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMSTPK13_P2, HUMSTPK13_P4, HUMSTPK13_P6, HUMSTPKl 3 P5 and HUMSTPKl 3 P9. DESCRIPTION FOR CLUSTER HUMTLEII

Cluster HUMTLEII features 10 transcript(s) and 49 segment(s) of interest, the names for which are given in Tables 3046 and 3047, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3048.

Table 3046 - Transcripts of interest

Transcript Name

HUMTLEII Tl

HUMTLEII T2

HUMTLEII T3

HUMTLEII T4

HUMTLEII TlO

HUMTLEII T14

HUMTLEII T28

HUMTLEII T34

HUMTLEII T37

HUMTLEII T39

Table 3047 - Segments of interest

Segment Name

HUMTLEΠ node 4

HUMTLEII node 16

HUMTLEII node 19

HUMTLEΠ node 21

HUMTLEII node 49

HUMTLEΠ node 60

HUMTLEΠ node 64

HUMTLEII node 75

HUMTLEΠ node 77

HUMTLEΠ_. node 79

HUMTLEII node 81

HUMTLEII node 88

HUMTLEII node 0

HUMTLEII node 5

HUMTLEΠ node 7

HUMTLEII node 9

HUMTLEΠ node 11 HUMTLEII node 13

HUMTLEII node 15

HUMTLEII node 17

HUMTLEII node 20

HUMTLEII node 23

HUMTLEII node 24

HUMTLEII node 29

HUMTLEII node 30

HUMTLEII node 32

HUMTLEΠ node 35

HUMTLEII node 36

HUMTLEII node 38

HUMTLEII node 39

HUMTLEII node 40

HUMTLEII node 46

HUMTLEII node 50

HUMTLEII node 53

HUMTLEΠ node 59

HUMTLEII node 61

HUMTLEII node 62

HUMTLEII node 65

HUMTLEΠ node 66

HUMTLEII node 67 HUMTLEII jαode 68

HUMTLEII node 71

HUMTLEII node 72

HUMTLEII node 73

HUMTLEΠ node 74

HUMTLEΠ node 80

HUMTLEII node 85

HUMTLEII node 90

HUMTLEΠ node 91

Table 3048 - Proteins of interest

These sequences are variants of the known protein Transducin- like enhancer protein 2 (SwissProt accession identifier TLE2_HUMAN; known also according to the synonyms ESG2), referred to herein as the previously known protein.

Protein Transducin- like enhancer protein 2 is known or believed to have the following function(s): Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNBl and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant- negative AES (By similarity). The sequence for protein Transducin- like enhancer protein 2 is given at the end of the application, as "Transducin- like enhancer protein 2 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3049.

Table 3049 - Amino acid mutations for Known Protein

Protein Transducin- like enhancer protein 2 localization is believed to be Nuclear.

The following GO Annotations) apply to the previously known protein. The following annotation(s) were found: transcription regulation; signal transduction; frizzled receptor signaling pathway, which are annotation(s) related to Biological Process; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on infoπnation from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from ^ttpV/www.ncbi.nlm.nih.gov/projects/LocusLink/^. As noted above, cluster HUMTLEII features 49 segment(s), which were listed in Table

3047 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMTLEII_node_4 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T2, HUMTLEII_T4 and HUMTLEII_TIO. Table 3050 below describes the starting and ending position of this segment on each transcript.

Table 3050 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_16 according to the present invention is supported by

5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T3. Table 3051 below describes the starting and ending position of this segment on each transcript.

Table 3051 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII JP2.

Segment cluster HUMTLEII_node_19 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T2, HUMTLEII_T3 and HUMTLEII_T4. Table 3052 below describes the starting and ending position of this segment on each transcript.

Table 3052 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEIIJ^>2.

Segment cluster HUMTLEII_node_21 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4 and HUMTLEII_T10. Table 3053 below describes the starting and ending position of this segment on each transcript.

Table 3053 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII-P 1 and HUMTLEII_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_49 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEIIJB, HUMTLEII_T4, HUMTLEII_TIO and HUMTLEII_T14. Table 3054 below describes the starting and ending position of this segment on each transcript.

Table 3054 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P6 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_60 according to the present invention is supported by

55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3,

HUMTLEII_T4, HUMTLEIMTIO and HUMTLEII_T14. Table 3055 below describes the starting and ending position of this segment on each transcript.

Table 3055 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_64 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T28 and HUMTLEII_T39. Table 3056 below describes the starting and ending position of this segment on each transcript.

Table 3056 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P22 and HUMTLEII_P31.

Segment cluster HUMTLEII_node_75 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T39. Table 3057 below describes the starting and ending position of this segment on each transcript.

Table 3057 - Segment location on transcripts

This segment can be found in the following protein(s): HUMTLEII_P31.

Segment cluster HUMTLEII_node_77 according to the present invention is supported by 2 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T37. Table 3058 below describes the starting and ending position of this segment on each transcript.

Table 3058 - Segment location on transcripts

This segment can be found in the following protein(s): HUMTLEII_P30.

Segment cluster HUMTLEII_node_79 according to the present invention is supported by \3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T34. Table 3059 below describes the starting and ending position of this segment on each transcript.

Table 3059 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEHJP28.

Segment cluster HUMTLEII_node_81 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HtMTLEIIJB₅ HUMTLEII_T4, HUMTLEII_T10, HUMTLEπ_T14, HUMTLEII_T28, HUMTLEII_T34 and HUMTLEII_T37. Table 3060 below describes the starting and ending position of this segment on each transcript.

Table 3060 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P10, HUMTLEII_P22, HUMTLEII P28 and HUMTLEII_P30, since it is m_Jhe_ coding _region_for Jhe corresponding transcript.

Segment cluster HUMTLEII_node_88 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII T1, HUMTLEII_T2, HUMTLEII_T3, HUMTLEπ_T4, HUMTLEII_TIO, HUMTLEII_T14, HUMTLEII_T28, HUMTLEII_T34 and HUMTLEII_T37. Table 3061 below describes the starting and ending position of this segment on each transcript.

Table 3061 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEIIJP2, HUMTLEIIJP10, HUMTLEII_P22, HUMTLEII_P28 and HUMTLEII_P30, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

-Segment cluster HUMTLEII_node_0 according to the present invention-is- supported by-1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1. Table 3062 below describes the starting and ending position of this segment on each transcript.

Table 3062 - Segment location on transcripts

This segment can be found in the following protein(s): HUMTLEII_P1.

Segment cluster HUMTLEII_node_5 according to the present invention can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T4 and HUMTLEII_TIO. Table 3063 below describes the starting and ending position of this segment on each transcript. Table 3063 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P1 and HUMTLEII_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_7 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII T1, HUMTLEII_T2, HUMTLEII_T4 and

HUMTLEΠ_T10. Table 3064 below describes the starting and ending position of this segment on each transcript.

Table 3064 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P1 and HUMTLEII_P6, since it is in the coding region for the corresponding transcript. Segment cluster HUMTLEII_node_9 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T4 and HUMTLEII_T10. Table 3065 below describes the starting and ending position of this segment on each transcript.

Table 3065 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEIIJP1 and HUMTLEII_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_l 1 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T4 and HUMTLEII TIO. Table 3066 below describes the starting and ending position of this segment on each transcript.

Table 3066 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEIIJP1 and HUMTLEII_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_13 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T4 and HUMTLEIIjriO. Table 3067 below describes the starting and ending position of this segment on each transcript.

Table 3067 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can^" be foundln a non- coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEIIJP1 and HUMTLEII_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_15 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T3. Table 3068 below describes the starting and ending position of this segment on each transcript.

Table 3068 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2.

Segment cluster HUMTLEII_node_17 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4 and HUMTLEII_TIO. Table 3069 below describes the starting and ending position of this segment on each transcript.

Table 3069 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as -follows-.-The-segment can be found in a-non-coding -region of-transcript(s) that-are related to-the- following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEIIJPl and HUMTLEΪI_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_20 according to the present invention is supported by

27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4 and HUMTLEII_TIO. Table 3070 below describes the starting and ending position of this segment on each transcript.

Table 3070 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P1 and HUMTLEII_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_23 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T14. Table 3071 below describes the starting and ending position of this segment on each transcript.

Table 3071 - Segment location on transcripts

This segment can be found in the following protein(s): HUMTLEII_P10.

Segment cluster HUMTLEII_node_24 according to the present invention can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3, HUMTLEIIjriO and HUMTLEII_T14. Table 3072 below describes the starting and ending position of this segment on each transcript. Table 3072 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEIMP 1, HUMTLEII JP6 and HUMTLEIIJP10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_29 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_TIO and HUMTLEII_T14. Table 3073 below describes the starting and ending position of this segment on each transcript.

Table 3073 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII JP2. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P6 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_30 according to the present invention can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_T10 and HUMTLEII_T14. Table 3074 below describes the starting and ending position of this segment on each transcript.

Table 3074 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P6 and HUMTLEIIJPIO, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_32 according to the present invention is supported by

36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3,

HUMTLEII_T4, HUMTLEII_TIO and HUMTLEII_T14. Table 3075 below describes the starting and ending position of this segment on each transcript. Table 3075 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P6 and HUMTLEπ_P10, since it is in the coding region for the corresponding transcript. Segment cluster HUMTLEII_node_35 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEπ_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII _TlO and HUMTLEII_T14. Table 3076 below describes the starting and ending position of this segment on each transcript.

Table 3076 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : HUMTLEIIJP2. This__segment can also_be_ found in the following protein(s): HUMTLEDJP 1, HUMTLEII_P6 and HUMTLEII JPlO, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_36 according to the present invention is supported by

35 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMTLEDjπ, HUMTLED_T2, HUMTLEDJB, HUMTLEII_T4, HUMTLEII_T10 and HUMTLEII_T14. Table 3077 below describes the starting and ending position of this segment on each transcript. Table 3077 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII-P 1, HUMTLEII_P6 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_38 according to the present invention can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII T3, HUMTLEII_T4, HUMTLEII_TIO and HUMTLEII_T14. Table 3078 below describes the starting and ending position of this segment on each transcript.

Table 3078 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P6 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_39 according to the present invention is supported by

39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEH_T3, HUMTLEII_T4, HUMTLEII_T10 and HUMTLEII_T14. Table 3079 below describes the starting and ending position of this segment on each transcript. Table 3079 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEIIJP6 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_40 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can _bejound_in_ the following transcript(s): HUMTLEII_Tl^HT^TLEII_T2,_HUMTLEπ_T3,_ HUMTLEII_T4, HUMTLEII_T10 and HUMTLEII_T14. Table 3080 below describes the starting and ending position of this segment on each transcript.

Table 3080 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P2. This segment can also be found in the following protein(s): HUMTLEIIJPl, HUMTLEII_P6 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_46 according to the present invention is supported by 1 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMTLEII_TIO. Table 3081 below describes the starting and ending position of this segment on each transcript.

Table 3081 - Segment location on transcripts

This segment can be found in the following protein(s): HUMTLEII_P6.

Segment cluster HUMTLEII_node_50 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3, HUMTLEirT4rHUMTLΕirτl0^"~and^~ΗUMTLEirT14^~Table^~"3082 below^~de^~sΕnDe^"s^~τhe^~ starting and ending position of this segment on each transcript.

Table 3082 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2 and HUMTLEIIJP10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_53 according to the present invention is supported by 42 libraries. The number of libraπes was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_T10 and HUMTLEII_T14. Table 3083 below describes the starting and ending position of this segment on each transcript.

Table 3083 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As_described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 3084. Table 3084 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript. Segment cluster HUMTLEII_node_59 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl , HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_TIO and HUMTLEII_T14. Table 3085 below describes the starting and ending position of this segment on each transcript.

Table 3085 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following prote_in(s): HUMTLEIIJP1, HUMTLEII_P2 and HUMTLEII P10, since it is in the_codin£ region for the corresponding transcript.

Segment cluster HUMTLEII_node_61 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3,

HUMTLEII_T4, HUMTLEII_T10 and HUMTLEII_T14. Table 3086 below describes the starting and ending position of this segment on each transcript.

Table 3086 - Segment location on transcripts

HUMTLEII T14 992 1017

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_62 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_TIO and HUMTLEII_T14. Table 3087 below describes the starting and ending position of this segment on each transcript.

Table 3087 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2 and HUMTLEII_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEϋ_node_65 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_T10, HUMTLEII_T14, HUMTLEII_T28 and HUMTLEII _T39. Table 3088 below describes the starting and ending position of this segment on each transcript.

Table 3088 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEIIJP6, HUMTLEIIJP22 and HUMTLEII_P31. This segment can also be found in the following protein(s): HUMTLEII__P1, HUMTLEII_P2 and HUMTLEIIJP 10, since it is in the coding region for the corresponding transcript.

-10-

Segment cluster HUMTLEII_node_66 according to the present invention is supported by

65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3,

HUMTLEII_T4, HUMTLEII_T10, HUMTLEII_T14, HUMTLEII_T28 and HUMTLEII_T39.

15 Table 3089 below describes the starting and ending position of this segment on each transcript.

Table 3089 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6, HUMTLEII_P22 and HUMTLEII_P31. This segment can also be found in the following protein(s): HUMTLEIMP 1, HUMTLEII JP2 and

HUMTLEIIJP 10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_67 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_TIO, HUMTLEII_T14, HUMTLEII_T28 and HUMTLEII_T39. Table 3090 below describes the starting and ending position of this segment on each transcript.

Table 3090 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6, HUMTLEII_P22 and HUMTLEII P31. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2 and HUMTLEIIJP 10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_68 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEH_T3, HUMTLEII_T4, HUMTLEII_T10, HUMTLEII_T14, HUMTLEII_T28 and HUMTLEII_T39. Table 3091 below describes the starting and ending position of this segment on each transcript.

Table 3091 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P10, HUMTLEII_P22 and HUMTLEII_P31 , since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_71 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_T10, HUMTLEII_T14, HUMTLEII_T28 and HUMTLEII_T39. Table 3092 below describes the starting and ending position of this segment on each transcript.

Table 3092 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII JP6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P10, HUMTLEII_P22 and

HUMTLEII_P31, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_72 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_T10, HUMTLEII_T14, HUMTLEII_T28 and HUMTLEII_T39. Table 3093 below describes the starting and ending position of this segment on each transcript.

Table 3093 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P10, HUMTLEII_P22 and HUMTLEII_P31, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_73 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEH_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_T IO, HUMTLEII_T14, HUMTLEII_T28 and HUMTLEII JB 9. Table 3094 below describes the starting and ending position of this segment on each transcript.

Table 3094 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that arc related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEIIJPIO, HUMTLEII_P22 and HUMTLEH_P31, since it is in the coding region for the corresponding transcript.

-10

Segment cluster HUMTLEII_node_74 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_T1, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEH_TIO, HUMTLEII_T14, HUMTLEII_T28 and HUMTLEII_T39.

15 Table 3095 below describes the starting and ending position of this segment on each transcript.

Table 3095 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P10, HUMTLEII_P22 and

HUMTLEII_P31, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEIIjnode_80 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_T10, HUMTLEII_T14, HUMTLEII_T28, HUMTLEII_T34 and HUMTLEII_T37. Table 3096 below describes' the starting and ending position of this segment on each transcript.

Table 3096 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P6 and HUMTLEIIJP28. This segment can also be found in the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P10, HUMTLEII_P22 and HUMTLEII_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_85 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII-T 10, HUMTLEII_T14, HUMTLEII_T28, HUMTLEII_T34 and HUMTLEII_T37. Table 3097 below describes the starting and ending position of this segment on each transcript.

Table 3097 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the Jollowing prqtein(s)i _HUMTLEII_P6.__This_segment__can.jιlso__be_foundJin_the jbllowing_. protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P10, HUMTLEII_P22, HUMTLEII_P28 and HUMTLEII_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTLEII_node_90 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_TIO, HUMTLEII_T14, HUMTLEII_T28, HUMTLEII_T34 and HUMTLEII_T37. Table 3098 below describes the starting and ending position of this segment on each transcript. Table 3098 - Segment location on transcripts

This segment can be found in a non-coding region of transcπpt(s) that are related to the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P6, HUMTLEII_P10, HUMTLEII P22, HUMTLEII P28 and HUMTLEII P30.

Segment cluster HUMTLEII_node_91 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously descπbed. This segment can be found in the following transcript(s): HUMTLEII_Tl, HUMTLEII_T2, HUMTLEII_T3, HUMTLEII_T4, HUMTLEII_TIO, HUMTLEII_T14, HUMTLEII_T28, HUMTLEII_T34 and HUMTLEII_T37. Table 3099 below describes the starting and ending position of this segment on each transcript.

Table 3099 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMTLEII_P1, HUMTLEII_P2, HUMTLEII_P6, HUMTLEII_P10, HUMTLEII_P22, HUMTLEII_P28 and HUMTLEII_P30. DESCRIPTION FOR CLUSTER HUMTYRKIN

Cluster HUMTYRKIN features 5 transcript(s) and 33 segment(s) of interest, the names for which are given in Tables 3100 and 3101, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3102.

Table 3100 - Transcripts of interest

Transcript Name <

HUMTYRKIN Tl

HUMTYRKIN T5

HUMTYRKTN T6

HUMTYRKIN T21

HUMTYRKIN T25

Table 3101 - Segments of interest

Segment Name

HUMTYRKIN node 0

HUMTYRKTN node 6

HUMTYRKIN node 12

HUMTYRKIN node 17

HUMTYRKIN node 18

HUMTYRKIN node _.23

HUMTYRKIN node 26

HUMTYRKTN node 28

HUMTYRKIN node 30

HUMTYRKIN node 34

HUMTYRKTN node 42

HUMTYRKIN node 46

HUMTYRKTN node 47

HUMTYRKIN node 48

HUMTYRKIN node 49

HUMTYRKIN node 50

HUMTYRKIN node 2

HUMTYRKIN node 4

HUMTYRKIN node 13

HUMTYRKIN node 15 HUMTYRKJN node 20

HUMTYRKIN node 22

HUMTYRKIN node 24

HUMTYRKIN node 25

HUMTYRKIN node 27

HUMTYRKIN node 29

HUMTYRKTN node 31

HUMTYRKTN node 32

HUMTYRKTN node 33

HUMTYRKTN node 38

HUMTYRKTN node 39

HUMTYRKTN node 44

HUMTYRKTN node 45

Table 3102 - Proteins of interest

These sequences are variants of the known protein Tyrosine-protein kinase ZAP -70 (SwissProt accession identifier ZA70_HUMAN; known also according to the synonyms EC

2.7.1.112; 70 kDa zeta- associated protein; Syk-related tyrosine kinase), referred to herein as the previously known protein.

Protein Tyrosine-protein kinase ZAP -70 is known or believed to have the following function(s): Associates with the T-cell antigen receptor zeta chain (CD3Z). Plays a role in lymphocyte activation. The sequence for protein Tyrosine-protein kinase ZAP-70 is given at the end of the application, as "Tyrosine-protein kinase ZAP-70 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3103.

Table 3103 -Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotations) were found: protein amino acid phosphorylation; immune response; protein kinase cascade, which are annotation(s) related to Biological Process; and protein tyrosine kinase; protein binding; ATP binding; transferase, which are annotation(s) related to Molecular

Function.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster HUMTYRKTN features 33 segment(s), which were listed in Table 3101 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because- they-are-of-particular-interest-A-description .ofLeach-segment-according -to-the present- invention is now provided.

Segment cluster HUMTYRKTN_node_0 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T5, HUMTYRKTN_T6 and HUMTYRKIN_T21. Table 3104 below describes the starting and ending position of this segment on each transcript. Table 3104 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMT YRKINJP 1.

Segment cluster HUMTYRKIN_node_6 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T21. Table 3105 below describes the starting and ending position of this segment on each transcript.

Table 3105 - Segment location on transcripts

This segment can be found in the following protein(s): HUMTYRKIN-P 1.

Segment cluster HUMTYRKIN_node_12 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T21. Table 3106 below describes the starting and ending position of this segment on each transcript.

Table 3106 - Segment location on transcripts

This segment can be found in the following protein(s): HUMTYRKINJPl.

Segment cluster HUMTYRKIN_node_17 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HtMTYRKIN_Tl. Table 3107 below describes the starting and ending position of this segment on each transcript.

Table 3107 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2.

Segment cluster HUMTYRKIN_node_l 8 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKTN_Tl, HUMTYRKIN_T5,

HUMTYRKIN_T6, HUMTYRKIN_T21 and HUMTYRKJN_T25. Table 3108 below describes the starting and ending position of this segment on each transcript.

Table 3108 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKTN_P2. This segment can also be found in the following protein(s): HUMTYRKTN_P1, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKTN_node_23 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKTN_Tl, HUMTYRKTN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T21. Table 3109 below describes the starting and ending position of this segment on each transcript.

Table 3109 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2. This segment can also be found in the following protein(s): HUMT YRKINJPl, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKIN_node_26 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_Tl, HUMTYRKIN_T5,

HUMTΫRlONjrβ and HUMTYRKlN_T21. Table 3110 below describes the starting and ending position of this segment on each transcript.

Table 3110 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2 and HUMTYRKIN_Pl.

Segment cluster HUMTYRKIN_node_28 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5, HUMTYRKIN_T6, HUMTYRKIN_T21 and HUMTYRKIN_T25. Table 3111 below describes the starting and ending position of this segment on each transcript.

Table 3111 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2 and HUMTYRKIN_P1.

Segment cluster HUMTYRKIN_node_30 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5,

HUMTYRKJN_T6, HUMTYRKIN_T21 and HUMTYRKIN_T25. Table 3112 below describes the starting-and ending position-of this -segment-on each transcript.- — —

Table 3112 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2 and HUMTYRKIN_P1.

Segment cluster HUMTYRKIN_node_34 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMT YRKIN T21. Table 3113 below describes the starting and ending position of this segment on each transcript.

Table 3113 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN-P 1.

Segment cluster HUMTYRKIN_node_42 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKTN_T1, HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T25. Table 3114 below describes the starting and ending position of this segment on each transcript.

Table 3114 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKTN_P1. This segment can also be found in the following protein(s): HUMTYRKINJP2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKIN_node_46 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T6. Table 3115 below describes the starting and ending position of this segment on each transcript.

Table 3115 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P1.

Segment cluster HUMTYRKIN_node_47 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T6. Table 3116 below describes the starting and ending position of this segment on each transcript.

Table 3116 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P1.

Segment cluster HUMTYRKIN_node_48 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKTN_T5,

HUMTYRKIN_T6 and HUMTYRKIN_T25. Table 3117 below describes the starting and ending position of this segment on each transcript.

Table 3117 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P1. This segment can also be found in the following protein(s): HUMTYRKIN_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKIN_node_49 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T25. Table 3118 below describes the starting and ending position of this segment on each transcript.

Table 3118 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2 andHUMTYRKIN_Pl.

Segment cluster HUMTYRKIN_node_50 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T25. Table 3119 below describes the starting and ending position of this segment on each transcript.

Table 3119 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2 and HUMTYRKTN_P1. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMTYRKIN_node_2 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T21. Table 3120 below describes the starting and ending position of this segment on each transcript.

Table 3120 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : HUMTYRKIN_P 1.

Segment cluster HUMTYRKIN_node_4 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKTN_T5. Table 3121 below describes the starting and ending position of this segment on each transcript.

Table 3121 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKTN_P1. Segment cluster HUMTYRKJN_node_13 according to the present invention can be found m the following transcript(s): HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T21. Table 3122 below describes the starting and ending position of this segment on each transcript.

Table 3122 - Segment location on transcripts

This segment can be found in the following protein(s): HUMTYRKIN_P1.

Segment cluster HUMTYRKIN_node_l 5 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T25. Table 3123 below describes the starting and ending position of this segment on each transcript.

Table 3123 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKINJP2.

Segment cluster HUMTYRKIN_node_20 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5, HUMTYRKIN_T6, HUMTYRKIN_T21 and HUMTYRKTN_T25. Table 3124 below describes the starting and ending position of this segment on each transcript.

Table 3124 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2. This segment can also be found in the following protein(s): HUMTYRKIN_P1, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKIN_node_22 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5, HUMTYRKIN_T6, HUMTYRKIN_T21 and HUMTYRKTN_T25. Table 3125 below describes the starting and ending position of this segment on each transcript.

Table 3125 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2. This segment can also be found in the following protein(s): HUMTYRKIN_P1, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKIN_node_24 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_Tl, HUMTYRKIN_T5,

HUMTYRKTN_T6 and HUMTYRKJN_T21. Table 3126 below describes the starting and ending position of this segment on each transcript. Table 3126 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKINJP2 and HUMTYRKIN_Pl.

Segment cluster HUMTYRKIN_node_25 according to the present invention can be found in the following transcript(s): HUMTYRKIN_Tl, HUMTYRKIN_T5, HUMTYRKIN_T6, HUMTYRKIN_T21 and HUMTYRKIN_T25. Table 3127 below describes the starting and ending position of this segment on each transcript.

Table 3127 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2 and HUMTYRKJN_Pl.

Segment cluster HUMTYRKIN_node 27 according to the present invention can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5, HUMTYRKIN_T6, HUMTYRKIN_T21 and HUMTYRKIN_T25. Table 3128 below describes the starting and ending position of this segment on each transcript.

Table 3128 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2 and HUMTYRKIN_P1.

Segment cluster HUMTYRKIN_node_29 according to the present invention can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5, HUMTYRKTN_T6, HUMTYRKIN_T21 and HUMTYRKIN_T25. Table 3129 below describes the starting and ending position of this segment on each transcript.

Table 3129 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P2 and HUMTYRKIN_P1.

Segment cluster HUMTYRKIN_node_31 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_Tl, HUMTYRKIN_T5,

HUMTYRKIN_T6, HUMTYRKIN_T21 and HUMTYRKIN_T25. Table 3130 below describes the starting and ending position of this segment on each transcript.

Table 3130 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKTN_P1. This segment can also be found in the following protein(s): HUMTYRKIN_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKTN_node_32 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKTN_T1, HUMTYRKTN_T5, HUMTYRKIN T6, HUMTYRKIN_T21 and HUMTYRKIN_T25. Table 3131 below describes the starting and ending position of this segment on each transcript.

Table 3131 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKTNJPl. This segment can also be found in the following protein(s): HUMTYRKTN_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKIN_node_33 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKTN_T1, HUMTYRKIN_T5,

HUMTYRKIN_T6, HUMTYRKIN_T21 and HUMTYRKIN_T25. Table 3132 below describes the starting and ending position of this segment on each transcript. Table 3132 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P1. This segment can also be found in the following protein(s): HUMTYRKIN_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKTN_node_38 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_Tl, HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T25. Table 3133 below describes the starting and ending-position-of-this-segment-on-eaeh-transcript:

Table 3133 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKTN_P1. This segment can also be found in the following protein(s): HUMTYRKIN_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKIN_node_39 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5, HUMTYRKIN_T6 and HUMTYRKIN_T25. Table 3134 below describes the starting and ending position of this segment on each transcript.

Table 3134 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKINJPl. This segment can also be found in the following protein(s): HUMTYRKIN_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMTYRKIN_node_44 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T1, HUMTYRKIN_T5 , HUMTYRKIN_T6 and HUMTYRKIN_T25. Table 3135 below describes the starting and ending position of this segment on each transcript.

Table 3135 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKTN_P1. This segment can also be found in the following protein(s): HUMTYRKTN_P2, since it is in the coding region for the corresponding transcript. Segment cluster HUMTYRKIN_node_45 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMTYRKIN_T6. Table 3136 below describes the starting and ending position of this segment on each transcript.

Table 3136 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMTYRKIN_P1.

DESCRIPTION FOR CLUSTER M77903

Cluster M77903 features 7 transcript(s) and 35 segment(s) of interest, the names for which are given in Tables 3137 and 3138, respectively, the sequences themselves are given at the end of the application. THe selected protein variants are given in^"TabIe^~3T39. Table 3137 - Transcripts of interest

Transcript Name

M77903 T8

M77903 T19

M77903 T26

M77903 T28

M77903 T29

M77903 T30

M77903 T32

Table 3138 - Segments of interest

Segment Name

M77903 node 2

M77903 node 16

M77903 node 25

M77903 node 26 M77903 node 30

M77903 node 35

M77903 node 36

M77903 node 37

M77903 node 38

M77903 node 40

M77903 node 44

M77903 node 46

M77903 node 47

M77903 node 48

M77903 node 49

M77903 node 51

M77903 node 52

M77903 node 56

M77903 node 1

M77903 node 5

M77903 node 9

M77903 node 10

M77903 node 11

M77903 node 12

M77903 node 15

M77903 node 17

M77903 node 20

M779Ω3 node 22 ._. ..

M77903 node 28

M77903 node 29

M77903 node 31

M77903 node 32

M77903 node 34

M77903 node 41

M77903 node 42

Table 3139 - Proteins of interest

These sequences are variants of the known protein Translocon-associated protein, alpha subunit precursor (SwissProt accession identifier SSRA_HUMAN; known also according to the synonyms TRAP-alpha; Signal sequence receptor alpha subunit; SSR-alpha), referred to herein as the previously known protein. Protein Translocon-associated protein, alpha subunit precursor is known or believed to have the following function(s): TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. The sequence for protein Translocon-associated protein, alpha subunit precursor is given at the end of the application, as "Transloconeassociated protein, alpha subunit precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3140.

Table 3140 - Amino acid mutations for Known Protein

SNP position(s) on Comment amino acid sequence

28 L -> S

130 Y -> H Protein Translocon-associated protein, alpha subunit precursor localization is believed to be Type I membrane protein. Endoplasmic reticulum.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: co-translational membrane targeting; positive control of cell proliferation, which are annotation(s) related to Biological Process; signal sequence receptor; calcium binding, which are annotation(s) related to Molecular Function; and endoplasmic reticulum; integral membrane protein, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>. Cluster M77903 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 77 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 77 and Table 3141. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: ovarian carcinoma and uterine malignancies.

Table 3141 - Normal tissue distribution

Table 3142 - P values and ratios for expression in cancerous tissue

As noted above, cluster M77903 features 35 segment(s), which were listed in Table 3138 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M77903_node_2 according to the present invention is supported by 150 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3143 below describes the starting and ending position of this segment on each transcript.

Table 3143 - Segment location on transcripts

This segment can be found in the following protein(s): M77903JP3, M77903JP1,

M77903_P18, M779O3_P11, M77903_P12 and M77903_P2.

Segment cluster M77903_node_16 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28,

M77903_T29, M77903_T30 and M77903_T32. Table 3144 below describes the starting and ending position of this segment on each transcript.

Table 3144 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M77903_Pl, M77903_P18, M779O3_P11, M77903_P12 and M77903_P2. Segment cluster M77903_node_25 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8 and M77903_T32. Table 3145 below describes the starting and ending position of this segment on each transcript.

Table 3145 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3.

Segment cluster M77903_node_26 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T32. Table 3146 below describes the starting and ending position of this segment on each transcript.

Table 3146 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3.

Segment cluster M77903_node_30 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T30. Table 3147 below describes the starting and ending position of this segment on each transcript.

Table 3147 - Segment location on transcripts

This segment can be found in a non-codmg region of transcript(s) that are related to the following protein(s): M77903_P2.

Segment cluster M77903_node_35 according to the present invention is supported by 145 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19 and M77903_T26. Table 3148 below describes the starting and ending position of this segment on each transcript.

Table 3148 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3. This segment can also be found in the following protein(s): M779O3_P1 and M77903_P18, since it is in the coding region for the corresponding transcript.

Segment cluster M77903_node_36 according to the present invention is supported by 173 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8 and M77903_T19. Table 3149 below describes the starting and ending position of this segment on each transcript.

Table 3149 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M77903_P3 and M77903_PL Segment cluster M77903_node_37 according to the present invention is supported by 128 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8 and M77903_T19. Table 3150 below describes the starting and ending position of this segment on each transcript.

Table 3150 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3 and M779O3_P1.

Segment cluster M77903_node_38 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8 and M77903_T19. Table 3151 below describes the starting and ending position of this segment on each transcript.

Table 3151 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3 and M779O3_P1.

Segment cluster M77903_node_40 according to the present invention is supported by 186 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8 and M77903_T19. Table 3152 below describes the starting and ending position of this segment on each transcript.

Table 3152 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3 and M779O3_P1.

Segment cluster M77903_node_44 according to the present invention is supported by 122 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8. Table 3153 below describes the starting and ending position of this segment on each transcript.

Table 3153 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M77903JP3.

Segment cluster M77903_node_46 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8. Table 3154 below describes the starting and ending position of this segment on each transcript.

Table 3154 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M77903_P3. Segment cluster M77903_node_47 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8. Table 3155 below describes the starting and ending position of this segment on each transcript.

Table 3155 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3.

Segment cluster M77903_node_48 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8. Table 3156 below describes the starting and ending position of this segment on each transcript.

Table 3156 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3.

Segment cluster M77903_node_49 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8. Table 3157 below describes the starting and ending position of this segment on each transcript.

Table 3157 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3.

Segment cluster M77903_node_51 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8. Table 3158 below describes the starting and ending position of this segment on each transcript.

Table 3158 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3.

Segment cluster M77903_node_52 according to the present invention is supported by 160 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8. Table 3159 below describes the starting and ending position of this segment on each transcript.

Table 3159 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M77903_P3.

Segment cluster M77903_node_56 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T19, M77903_T26, M77903_T28 and M77903_T29. Table 3160 below describes the starting and ending position of this segment on each transcript.

Table 3160 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M779O3_P1 and M77903JP18. This segment can also be found in the following protein(s): M779O3_P11 and M77903_P12, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M77903_node_l according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3161 below describes the starting and ending position of this segment on each transcript.

Table 3161 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3, M77903JP1, M77903_P18, M77903JP11, M77903_P12 and M77903 P2.

Segment cluster M77903_node_5 according to the present invention is supported by 154 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3162 below describes the starting and ending position of this segment on each transcript.

Table 3162 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M779O3_P1, M77903_P18, M77903JP11, M77903_P12 and M77903_P2.

Segment cluster M77903_node_9 according to the present invention can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3163 below describes the starting and ending position of this segment on each transcript.

Table 3163 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M779O3_P1, M77903_P18, M779O3_P11, M77903 J^>12 and M77903JP2.

Segment cluster M77903_node_10 according to the present invention is supported by 148 libraries. The number of libraries was determined as previously described. This segment can be found in ths following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3164 below describes the starting and ending position of this segment on each transcript.

Table 3164 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M77903JP1, M77903_P18, M77903JP11, M77903_P12 and M77903_P2.

Segment cluster M77903_node_l 1 according to the present invention can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903JB0 and M77903_T32. Table 3165 below describes the starting and ending position of this segment on each transcript.

Table 3165 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M779O3_P1, M77903_P18, M77903JP11, M77903_P12 and M77903_P2.

Segment cluster M77903_node_12 according to the present invention can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3166 below describes the starting and ending position of this segment on each transcript.

Table 3166 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M779O3_P1,

M77903_P18, M779O3_P11, M77903_P12 and M77903_P2.

Segment cluster M77903_node_15 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28,

M77903_T29, M77903_T30 and M77903_T32. Table 3167 below describes the starting and ending position of this segment on each transcript. Table 3167 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M779O3_P1, M77903_P18, M77903_Pl 1, M77903_P12 and M77903_P2.

Segment cluster M77903_node_17 according to the present invention is supported by 141 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3168 below describes the starting and ending position of this segment on each transcript.

Table 3168 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M779O3_P1, M77903_P18, M779O3_P11, M77903_P12 and M77903_P2.

Segment cluster M77903_node_20 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3169 below describes the starting and ending position of this segment on each transcript.

Table 3169 - Segment location on transcripts

This segment can be found in the following protein(s): M77903JP3, M779O3_P1,

M77903_P18, M779O3_P11, M77903_P12 and M77903_P2.

Segment cluster M77903_node_22 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29, M77903_T30 and M77903_T32. Table 3170 below describes the starting and ending position of this segment on each transcript.

Table 3170 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P3, M779O3_P1,

M77903 P18, M77903_Pl l, M77903 P12 and M77903 P2. Segment cluster M77903_node_28 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28, M77903_T29 and M77903_T30. Table 3171 below describes the starting and ending position of this segment on each transcript.

Table 3171 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3. This segment can also be found in the following protein(s):

M77903JP1, M77903_P18, M77903JP11, M77903_P12 and M77903_P2, since it is in the coding region for the corresponding transcript.

Segment cluster M77903_node_29 according to the present invention can be found in the following transcript(s): M77903_T30. Table 3172 below describes the starting and ending position of this segment on each transcript.

Table 3172 - Segment location on transcripts

This segment can be found in the following protein(s): M77903_P2. Segment cluster M77903_node_31 according to the present invention can be found in the following transcript(s): M77903_T29 and M77903_T30. Table 3173 below describes the starting and ending position of this segment on each transcript.

Table 3173 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903JP2. This segment can also be found in the following protein(s): M77903_P12, since it is in the coding region for the corresponding transcript.

Segment cluster M77903__node_32 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T30. Table 3174 below describes the starting and ending position of this segment on each transcript.

Table 3174 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P2.

Segment cluster M77903__node_34 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19, M77903_T26, M77903_T28 and M77903_T29. Table 39 below describes the starting and ending position of this segment on each transcript.

Table 3175 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3. This segment can also be found in the following protein(s): M77903JP1, M77903_P18, M779O3_P11 and M77903_P12, since it is in the coding region for the corresponding transcript.

Segment cluster M77903_node_41 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8, M77903_T19 and M77903_T26. Table 3176 below describes the starting and ending position of this segment on each transcript.

Table 3176 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3, M779O3_P1 and M77903_P18.

Segment cluster M77903_node_42 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M77903_T8. Table 3177 below describes the starting and ending position of this segment on each transcript.

Table 3177 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M77903_P3.

DESCRIPTION FOR CLUSTER M78445

Cluster M78445 features 4 transcript(s) and 42 segment(s) of interest, the names for which are given in Tables 3178 and 3179, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3180.

Table 3178 - Transcripts of interest

Transcript Name

M78445_ _T0

M78445 Tl

M78445 T24

M78445 T44

Table 3179 - Segments of interest

Segment Name

M78445_ node 0

M78445 node 4

M78445 node 35

M78445 node 36

M78445 node 42

M78445 node 47

M78445 node 48

M78445 node 60

M78445 node 64

M78445 node 67

M78445 node 73

M78445 node 74

M78445 node 75 M78445 node 76

M78445 node 78

M78445 node 80

M78445 node 81

M78445 node 82

M78445 node 84

M78445 node 87

M78445 node 90

M78445 node 91

M78445 node 5

M78445 node 6

M78445 node 7

M78445 node 38

M78445 node 40

M78445 node 44

M78445 node 45

M78445 node 55

M78445 node 56

M78445 node 62

M78445 node 69

M78445 node 70

M78445 node 71

M78445 node 72

M78445 node 77

M78445 node 79

M78445_ node 83

M78445 node 85

M78445 node 86

M78445 node 88

Table 3180 - Proteins of interest

These sequences are variants of the known protein CUG triplet repeat RNA-binding protein 1 (SwissProt accession identifier CUG1_HUMAN; known also according to the synonyms CUG-BPl; RNA-binding protein BRUNOL-2; Deadenylation factor CUG-BP; 50 kDa Nuclear polyadenylated RNA-binding protein; EDEN-BP), referred to herein as the previously known protein. Protein CUG triplet repeat RNA-binding protein 1 is known or believed to have the following function(s): Regulates splicing and translation of various RNAs. Binds to (CUG)n triplet repeats and to Bruno response elements. The sequence for protein CUG triplet repeat RNA-binding protein 1 is given at the end of the application, as "CUG triplet repeat RNA- binding protein 1 amino acid sequence". Protein CUG triplet repeat RNA-binding protein 1 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: mRNA splice site selection; mRNA processing; germ- cell development; RNA interference, which are annotation(s) related to Biological Process; RNA binding; pre-mRNA splicing factor, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster M78445 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 78 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 78 and Table 3181. This cluster is overexpressed (at least at a minimum level) in Hie following pathological conditions: ovarian carcinoma.

Table 3181 - Normal tissue distribution

Table 3182 - P values and ratios for expression in cancerous tissue

As noted above, cluster M78445 features 42 segment(s), which were listed in Table 3179 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M78445_node_0 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T1. Table 3183 below describes the starting and ending position of this segment on each transcript.

Table 3183 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1.

Segment cluster M78445_node_4 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0 and M78445_T44. Table 3184 below describes the starting and ending position of this segment on each transcript. Table 3184 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P11.

Segment cluster M78445_node_35 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T24. Table 3185 below describes the starting and ending position of this segment on each transcript.

Table 3185 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P6.

Segment cluster M78445_node_36 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1, M78445_T24 and M78445_T44. Table 3186 below describes the starting and ending position of this segment on each transcript.

Table 3186 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P6. This segment can also be found in the following protein(s): M78445_P1 and M78445_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78445_node_42 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1, M78445_T24 and M78445_T44. Table 3187 below describes the starting and ending position of this segment on each transcript.

Table 3187 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P6. This segment can also be found in the following protein(s): M78445_P1 and M78445_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78445_node_47 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1, M78445_T24 and

M78445_T44. Table 3188 bebw describes the starting and ending position of this segment on each transcript.

Table 3188 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1, M78445_P6 and M78445_P11.

Segment cluster M78445_node_48 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T44. Table 3189 below describes the starting and ending position of this segment on each transcript.

Table 3189 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P11.

Segment cluster M78445_node_60 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3190 below describes the starting and ending position of this segment on each transcript.

Table 3190 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_64 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3191 below describes the starting and ending position of this segment on each transcript.

Table 3191 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445JP6.

Segment cluster M78445__node_67 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3192 below describes the starting and ending position of this segment on each transcript.

Table 3192 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_73 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3193 below describes the starting and ending position of this segment on each transcript.

Table 3193 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445JP6.

Segment cluster M78445_node_74 according to the present invention is supported by 97 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3194 below describes the starting and ending position of this segment on each transcript.

Table 3194 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_75 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3195 below describes the starting and ending position of this segment on each transcript.

Table 3195 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6. Segment cluster M78445_node_76 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3196 below describes the starting and ending position of this segment on each transcript.

Table 3196 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_78 according to the present invention is supported by 168 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3197 below describes the starting and ending position of this segment on each transcript.

Table 3197 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_80 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3198 below describes the starting and ending position of this segment on each transcript.

Table 3198 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445__node_81 according to the present invention is supported by 48 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3199 below describes the starting and ending position of this segment on each transcript.

Table 3199 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_82 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3200 below describes the starting and ending position of this segment on each transcript.

Table 3200 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445JP6.

Segment cluster M78445_node_84 according to the present invention is supported by 159 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3201 below describes the starting and ending position of this segment on each transcript.

Table 3201 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_87 according to the present invention is supported by 246 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445JTO, M78445_T1 and M78445_T24. Table 3202 below describes the starting and ending position of this segment on each transcript.

Table 3202 - Segment location on transcripts

This segment can be found in a non-coding region of transcriρt(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_90 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3203 below describes the starting and ending position of this segment on each transcript.

Table 3203 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_91 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3204 below describes the starting and ending position of this segment on each transcript.

Table 3204 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M78445_node_5 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T44. Table 3205 below describes the starting and ending position of this segment on each transcript.

Table 3205 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445JP11.

Segment cluster M78445_node_6 according to the present invention can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T44. Table 3206 below describes the starting and ending position of this segment on each transcript.

Table 3206 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445JP11.

Segment cluster M78445_node_7 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T44. Table 3207 below describes the starting and ending position of this segment on each transcript.

Table 3207 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P11.

Segment cluster M78445_node_38 according to the present invention is supported by 57 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1, M78445_T24 and M78445_T44. Table 3208 below describes the starting and ending position of this segment on each transcript. Table 3208 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P6. This segment can also be found in the following protein(s): M78445_P1 and M78445_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78445_node_40 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1, M78445_T24 and M78445_T44. Table 3209 below describes the starting and ending position of this segment on each transcript.

Table 3209 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P6. This segment can also be found in the following protein(s): M78445_P1 and M78445_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78445_node_44 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T44. Table 3210 below describes the starting and ending position of this segment on each transcript.

Table 3210 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P11.

Segment cluster M78445_node_45 according to the present invention can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T44. Table 3211 below describes the starting and ending position of this segment on each transcript.

Table 3211 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P11. Segment cluster M78445_node_55 according to the present invention can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3212 below describes the starting and ending position of this segment on each transcript.

Table 3212 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_56 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3213 below describes the starting and ending position of this segment on each transcript.

Table 3213 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_62 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445JTO, M78445_T1 and M78445_T24. Table 3214 below describes the starting and ending position of this segment on each transcript.

Table 3214 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_69 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3215 below describes the starting and ending position of this segment on each transcript.

Table 3215 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_70 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3216 below describes the starting and ending position of this segment on each transcript.

Table 3216 - Segment location on transcripts

This segment can be found in the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_71 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s) : M78445_T0, M78445_T1 and M78445_T24. Table 3217 below describes the starting and ending position of this segment on each transcript.

Table 3217 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_72 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3218 below describes the starting and ending position of this segment on each transcript.

Table 3218 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P 1 and M78445_P6.

Segment cluster M78445_node_77 according to the present invention can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3219 below describes the starting and ending position of this segment on each transcript. Table 3219 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_79 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3220 below describes the starting and ending position of this segment on each transcript.

Table 3220 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445JP1 and M78445_P6.

Segment cluster M78445_node_83 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3221 below describes the starting and ending position of this segment on each transcript.

Table 3221 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6. Segment cluster M78445jnode_85 according to the present invention is supported by 136 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3222 below describes the starting and ending position of this segment on each transcript.

Table 3222 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_86 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3223 below describes the starting and ending position of this segment on each transcript.

Table 3223 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

Segment cluster M78445_node_88 according to the present invention can be found in the following transcript(s): M78445_T0, M78445_T1 and M78445_T24. Table 3224 below describes the starting and ending position of this segment on each transcript.

Table 3224 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78445_P1 and M78445_P6.

DESCRIPTION FOR CLUSTER M79251

Cluster M79251 features 2 transcript(s) and 26 segment(s) of interest, the names for which are given in Tables 3225 and 3226, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3227.

Table 3225 - Transcripts of interest

Transcript Name

M79251 T7

M79251 T27

Table 3226 - Segments of interest

Segment Name

M79251 node 2

M79251 node 14

M79251 node 19

M79251 node 27

M79251 node 29

M79251 node 31

M79251_ _node_ 35

M79251 node 49

M79251 node 52

M79251 node 53

M79251 node 57

M79251 node 1

M79251 node 10 M79251 node 11

M79251 node 18

M79251 node 24

M79251 node 25

M79251 node 33

M79251 node 39

M79251 node 42

M79251 node 48

M79251 node 50

M79251 node 51

M79251 node 54

M79251 node 55

M79251 node 56

Table 3227 - Proteins of interest

These sequences are variants of the known protein DnaJ homolog subfamily A member 3, mitochondrial precursor (SwissProt accession identifier DJA3_HUMAN; known also according to the synonyms Tumorous imaginal discs protein Tid56 homolog; DnaJ protein Tid-1; hTid-1), referred to herein as the previously known protein.

Protein DnaJ homolog subfamily A member 3, mitochondrial precursor is known or believed to have the following function(s): Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. The sequence for protein DnaJ homolog subfamily A member 3, mitochondrial precursor is given at the end of the application, as "DnaJ homolog subfamily A member 3, mitochondrial precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3228.

Table 3228 - Amino acid mutations for Known Protein

Protein DnaJ homolog subfamily A member 3, mitochondrial precursor localization is believed to be Mitochondrial matrix.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein folding; apoptosis, which are annotation(s) related to Biological Process; chaperone, which are annotation(s) related to Molecular Function; and mitochondrion, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster M79251 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y axis of Figure 79 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to tie histograms in

Figure 79 and Table 3229. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: bone malignant tumors, epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 3229 - Normal tissue distribution

Table 3230 - P values and ratios for expression in cancerous tissue

As noted above, cluster M79251 features 26 segment(s), which were listed in Table 3226 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M79251_node_2 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7 and M79251_T27. Table 3231 below describes the starting and ending position of this segment on each transcript.

Table 3231 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6. This segment can also be found in the following protein(s): M79251_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M79251_node_14 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3232 below describes the starting and ending position of this segment on each transcript.

Table 3232 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6. Segment cluster M79251_node_19 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T27. Table 3233 below describes the starting and ending position of this segment on each transcript.

Table 3233 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P15.

Segment cluster M7925 l_node_27 according to the present invention is supported by 97 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3234 below describes the starting and ending position of this segment on each transcript.

Table 3234 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6.

Segment cluster M7925 l_node_29 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3235 below describes the starting and ending position of this segment on each transcript.

Table 3235 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6. Segment cluster M79251_node_31 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3236 below describes the starting and ending position of this segment on each transcript.

Table 3236 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6.

Segment cluster M79251_node_35 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3237 below describes the starting and ending position of this segment on each transcript.

Table 3237 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6.

Segment cluster M79251_node_49 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3238 below describes the starting and ending position of this segment on each transcript.

Table 3238 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6. Segment cluster M79251_node_52 according to the present invention is supported by 135 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3239 below describes the starting and ending position of this segment on each transcript.

Table 3239 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6.

Segment cluster M79251_node_53 according to the present invention is supported by 142 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3240 below describes the starting and ending position of this segment on each transcript.

Table 3240 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79251_P6.

Segment cluster M79251_node_57 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3241 below describes the starting and ending position of this segment on each transcript.

Table 3241 - Segment location on transcripts

M79251 T7 2674 2811

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M7925 l_node_l according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7 and M79251_T27. Table 3242 below describes the starting and ending position of this segment on each transcript.

Table 3242 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79251_P6 and M79251_P15.

Segment cluster M79251_node_10 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7 and M79251_T27. Table 3243 below describes the starting and ending position of this segment on each transcript.

Table 3243 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6. This segment can also be found in the following protein(s): M79251_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M79251_node_l l according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7 and M79251_T27. Table 3244 below describes the starting and ending position of this segment on each transcript.

Table 3244 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6. This segment can also be fcund in the following protein(s): M79251_P15, since it is in the coding region for the corresponding transcript.

Segment cluster M79251_node_18 according to the present invention is supported by 105 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7 and M79251_T27. Table 3245 below describes the starting and ending position of this segment on each transcript.

Table 3245 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6 and M79251_P15. Segment cluster M79251_node_24 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3246 below describes the starting and ending position of this segment on each transcript.

Table 3246 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6.

Segment cluster M79251_node_25 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3247 below describes the starting and ending position of this segment on each transcript.

Table 3247 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6.

Segment cluster M79251_node_33 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3248 below describes the starting and ending position of this segment on each transcript.

Table 3248 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6. Segment cluster M79251_node_39 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3249 below describes the starting and ending position of this segment on each transcript.

Table 3249 - Segment location on transcripts

This segment can be found in the following protein(s): M79251JP6.

Segment cluster M79251_node_42 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3250 below describes the starting and ending position of this segment on each transcript.

Table 3250 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6.

Segment cluster M79251_node_48 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3251 below describes the starting and ending position of this segment on each transcript.

Table 3251 - Segment location on transcripts

This segment can be found in the following protein(s): M79251_P6. Segment cluster M7925 l_node_50 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3252 below describes the starting and ending position of this segment on each transcript.

Table 3252 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6.

Segment cluster M79251_node_51 according to the present invention is supported by 95 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3253 below describes the starting and ending position of this segment on each transcript.

Table 3253 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6.

Segment cluster M79251_node_54 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3254 below describes the starting and ending position of this segment on each transcript.

Table 3254 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6.

Segment cluster M79251_node_55 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3255 below describes the starting and ending position of this segment on each transcript.

Table 3255 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79251_P6.

Segment cluster M79251_node_56 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79251_T7. Table 3256 below describes the starting and ending position of this segment on each transcript.

Table 3256 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79251_P6.

DESCRIPTION FOR CLUSTER M85927

Cluster M85927 features 3 transcript(s) and 15 segment(s) of interest, the names for which are given in Tables 3257 and 3258, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3259. Table 3257 - Transcripts of interest

Transcript Name

M85927 TO

M85927 T3

M85927 T5

Table 3258 - Segments of interest

Segment Name

M85927 node _0

M85927 node 3

M85927 node 4

M85927 node 5

M85927 node 9

M85927 node 10

M85927 node 13

M85927 node 14

M85927 node 15

M85927 node 1

M85927 node 6

M85927 node 7

M85927 node 8

M85927 node 11

M85927 node 12

Table 3259 - Proteins of interest

Cluster M85927 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 80 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 80 and Table 3260. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors and prostate cancer. Table 3260 - Normal tissue distribution

Table 3261 - P values and ratios for expression in cancerous tissue

As noted above, cluster M85927 features 15 segment(s), which were listed in Table 3258 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M85927_node_0 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T3. Table 3262 below describes the starting and ending position of this segment on each transcript.

Table 3262 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M85927_P1.

Segment cluster M85927_node_3 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0 and M85927_T5. Table 3263 below describes the starting and ending position of this segment on each transcript.

Table 3263 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P6 and M85927_P2.

Segment cluster M85927_node_4 according to the present invention is supported by 160 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M85927_T0 and M85927_T5. Table 3264 below describes the starting and ending position of this segment on each transcript.

Table 3264 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P6 and M85927_P2.

Segment cluster M85927_node_5 according to the present invention is supported by 184 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3265 below describes the starting and ending position of this segment on each transcript.

Table 3265 - Segment location on transcripts

M85927 T5 1294 1415

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P2. This segment can also be found in the following protein(s): M85927_P6 and M85927_P1, since it is in the coding region for the corresponding transcript.

Segment cluster M85927_node_9 according to the present invention is supported by 132 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3266 below describes the starting and ending position of this segment on each transcript.

Table 3266 - Segment location on transcripts

This segment can be found in the following protein(s): M85927JP6, M85927_P1 and M85927_P2.

Segment cluster M85927_node_10 according to the present invention is supported by 135 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3267 below describes the starting and ending position of this segment on each transcript.

Table 3267 - Segment location on transcripts

This segment can be found in the following protein(s): M85927_P6, M85927_P1 and M85927 P2. Segment cluster M85927_node_13 according to the present invention is supported by 223 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3268 below describes the starting and ending position of this segment on each transcript.

Table 3268 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P6, M85927_P1 and M85927_P2.

Segment cluster M85927_node_14 according to the present invention is supported by 289 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3269 below describes the starting and ending position of this segment on each transcript.

Table 3269 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P6, M85927_P1 and M85927_P2.

Segment cluster M85927_node_15 according to the present invention is supported by 143 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3270 below describes the starting and ending position of this segment on each transcript. Table 3270 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P6, M85927_P1 and M85927JP2.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M85927_node_l according to the present invention can be found in the following transcript(s): M85927_T3. Table 3271 below describes the starting and ending position of this segment on each transcript.

Table 3271 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M85927JP1.

Segment cluster M85927_node_6 according to the present invention is supported by 183 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927JTO, M85927_T3 and M85927_T5. Table 3272 below describes the starting and ending position of this segment on each transcript.

Table 3272 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P2. This segment can also be found in the following protein(s): M85927_P6 and M85927_P1, since it is in the coding region for the corresponding transcript.

Segment cluster M85927_node_7 according to the present invention is supported by 170 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0 and M85927_T3. Table 3273 below describes the starting and ending position of this segment on each transcript.

Table 3273 - Segment location on transcripts

This segment can be found in the following protein(s): M85927_P6 and M85927JP1.

Segment cluster M85927_node_8 according to the present invention is supported by 153 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3274 below describes the starting and ending position of this segment on each transcript.

Table 3274 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P2. This segment can also be found in the following protein(s): M85927_P6 and M85927_P1, since it is in the coding region for the corresponding transcript.

Segment cluster M85927_node_l l according to the present invention is supported by 96 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3275 below describes the starting and ending position of this segment on each transcript.

Table 3275 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M85927_P6, M85927_P1 and M85927_P2.

Segment cluster M85927_node_12 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M85927_T0, M85927_T3 and M85927_T5. Table 3276 below describes the starting and ending position of this segment on each transcript.

Table 3276 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M85927_P6, M85927_P1 and M85927_P2. DESCRIPTION FOR CLUSTER R 14741

Cluster Rl 4741 features 8 transcript(s) and 10 segment(s) of interest, the names for which are given in Tables 3277 and 3278, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3279.

Table 3277 - Transcripts of interest

Transcript Name

R14741 TO

R14741 Tl

R14741 T2

R14741 T3

R14741 T4

R14741 T5

R14741 T6

R14741 T7

Table 3278 - Segments of interest

Segment Name

R14741 node 0

R14741 node 2

R14741 node 3

R14741 node 4

R14741 node 5

R14741 node 6

R14741 node 8

R14741 node 9

R14741 node 10

R14741 node 7

Table 3279 - Proteins of interest

These sequences are variants of the known protein Zinc finger protein ZIC 2 (SwissProt accession identifier ZIC2_HUMAN; known also according to the synonyms Zinc finger protein of the cerebellum 2), referred to herein as the previously known protein.

Protein Zinc finger protein ZIC 2 is known or believed to have the following function(s): Involved in cerebellar development (By similarity). The sequence for protein Zinc finger protein ZIC 2 is given at the end of the application, as "Zinc finger protein ZIC 2 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3280.

Table 3280 - Amino acid mutations for Known Protein

Protein Zinc finger protein ZIC 2 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: developmental processes; neurogenesis; brain development, which are annotation(s) related to Biological Process; DNA binding, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster R14741 features 10 segment(s), which were listed in Table 3278 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster R14741_node_0 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741 T0, R14741_T5 and R14741_T7. Table 3281 below describes the starting and ending position of this segment on each transcript.

Table 3281 - Segment location on transcripts

This segment can be found in the following protein(s): R14741_P1, R14741_P6 and R14741JP7.

Segment cluster R14741_node_2 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741_T1, R14741_T2, R14741_T3, R14741_T4 and R14741_T6. Table 3282 below describes the starting and ending position of this segment on each transcript. Table 3282 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R14741_P2, R14741_P3, R14741_P4 and R14741_P5.

Segment cluster R14741_node_3 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741_T1, R14741_T2, R14741_T3 and R14741_T4. Table 3283 below describes the starting and ending position of this segment on each transcript.

Table 3283 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 3284.

Table 3284 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R14741_P3, R14741_P4 and R14741_P5. This segment can also be found in the following protein(s): R14741_P2, since it is in the coding region for the corresponding transcript.

Segment cluster R14741_node_4 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741_T2, R14741_T3 and R14741_T4. Table 3285 below describes the starting and ending position of this segment on each transcript.

Table 3285 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R14741_P3, R14741_P4 and R14741_P5.

Segment cluster R14741_node_5 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741_T0, R14741_T1, R14741_T2, R14741_T3, R14741_T4, R14741_T5, R14741_T6 and R14741_T7. Table 3286 below describes the starting and ending position of this segment on each transcript.

Table 3286 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R14741_P5. This segment can also be found in the following protein(s): R14741_P1, R14741_P2, R14741_P3, R14741_P4, R14741_P6 and R14741_P7, since it is in the coding region for the corresponding transcript.

Segment cluster R14741_node_6 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741_T3 and R14741_T5. Table 3287 below describes the starting and ending position of this segment on each transcript.

Table 3287 - Segment location on transcripts

This segment can be found in the following protein(s): R14741_P4 and R14741_P6.

Segment cluster R14741_node_8 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741JIO, R14741_T1, R14741_T2, R14741_T3, R14741_T4, R14741_T5, R14741_T6 and R14741_T7. Table 3288 below describes the starting and ending position of this segment on each transcript.

Table 3288 - Segment location on transcripts

This segment can be found in the following protein(s): R14741_P1, R14741_P2, R14741_P3, R14741_P4, R14741_P5, R14741_P6 and R14741_P7.

Segment cluster R14741_node_9 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741_T0, R14741_T1, R14741_T2, R14741_T3, R14741_T4, R14741_T5 and R14741_T6. Table 3289 below describes the starting and ending position of this segment on each transcript.

Table 3289 - Segment location on transcripts

This segment can be found in the following protein(s): R14741_P1, R14741_P2, R14741_P3, R14741_P4, R14741_P5 and R14741_P6.

Segment cluster R14741_node_10 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741_T0, R14741_T1, R14741_T2, R14741_T3, R14741_T4, R14741_T5, R14741_T6 and R14741_T7. Table 3290 below describes the starting and ending position of this segment on each transcript. Table 3290 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R14741JP1, R14741_P2, R14741_P3, R1474l_P4, R14741_P5 and R14741_P6. This segment can also be found in the following protein(s): R14741_JP7, since it is in the coding region for the corresponding transcript. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R14741_node_7 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R14741_T3, R14741_T4 and R14741_T5. Table 3291 below describes the starting and ending position of this segment on each transcript.

Table 3291 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R14741_P5. This segment can also be found in the following protein(s): R14741_P4 and R14741_P6, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER Rl 7570

Cluster Rl 7570 features 5 transcript(s) and 38 segment(s) of interest, the names for which are given in Tables 3292 and 3293, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3294.

Table 3292 - Transcripts of interest

Transcript Name

R17570 T3

R17570 T5

R17570 TlO

R17570 T24

R17570 T25 Table 3293 - Segments of interest

Table 3294 - Proteins of interest

These sequences are variants of the known protein Kinesin light chain 2 (SwissProt accession identifier KLC2_HUMAN; known also according to the synonyms KLC 2), referred to herein as the previously known protein.

Protein Kinesin light chain 2 is known or believed to have the following function(s): Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). The sequence for protein Kinesin light chain 2 is given at the end of the application, as "Kinesin light chain 2 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3295.

Table 3295 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: microtubule motor, which are annotation(s) related to Molecular Function; and kinesin, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster R17570 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 81 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 81 and Table 3296. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors.

Table 3296 - Normal tissue distribution

Table 3297 - P values and ratios for expression in cancerous tissue

As noted above, cluster R17570 features 38 segment(s), which were listed in Table 3293 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R17570_node_5 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3 and R17570_T10. Table 3298 below describes the starting and ending position of this segment on each transcript.

Table 3298 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R1757O_P1 and R17570_P4.

Segment cluster R17570_node_7 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T10 and R17570_T25. Table 3299 below describes the starting and ending position of this segment on each transcript.

Table 3299 - Segment location on transcripts

This segment can be found in the following protein(s): R17570JP1, R17570_P4 and R17570_P15.

Segment cluster R17570_node_10 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T5. Table 3300 below describes the starting and ending position of this segment on each transcript.

Table 3300 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R17570_P2.

Segment cluster R17570_node_15 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T5. Table 3301 below describes the starting and ending position of this segment on each transcript.

Table 3301 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R17570_P2.

Segment cluster R17570_node_17 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5 and R17570_T25. Table 3302 below describes the starting and ending position of this segment on each transcript.

Table 3302 - Segment location on transcripts

This segment can be found in the following protein(s): R17570JP1, R17570_P2 and

R17570 P15.

Segment cluster R17570_node_24 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T25. Table 3303 below describes the starting and ending position of this segment on each transcript.

Table 3303 - Segment location on transcripts

This segment can be found in the following protein(s): R17570JP1, R17570_P2, Rl 7570 P4 and R17570 P15. Segment cluster R17570_node_26 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T24. Table 3304 below describes the starting and ending position of this segment on each transcript.

Table 3304 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R17570_P14.

Segment cluster R17570_node_27 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T24. Table 3305 below describes the starting and ending position of this segment on each transcript.

Table 3305 - Segment location on transcripts

This segment can be found in the following protein(s): R17570_P14.

Segment cluster R17570_node_34 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10, R17570_T24 and R17570_T25. Table 3306 below describes the starting and ending position of this segment on each transcript.

Table 3306 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2, R17570_P4, R17570_P14 and R17570_P15.

Segment cluster R17570_node_46 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3307 below describes the starting and ending position of this segment on each transcript.

Table 3307 - Segment location on transcripts

This segment can be found in the following protein(s): R17570JP1, R17570_P2, R17570 P4 and R17570 P14.

Segment cluster R17570_node_48 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3308 below describes the starting and ending position of this segment on each transcript.

Table 3308 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2, R17570_P4 and R17570_P14.

Segment cluster R17570_node_53 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3309 below describes the starting and ending position of this segment on each transcript.

Table 3309 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2,

R17570 P4 and R17570 P14.

Segment cluster R17570_node_57 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3310 below describes the starting and ending position of this segment on each transcript.

Table 3310 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R17570JP1, R17570_P2, R17570_P4 and R17570_P14. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R17570_node_2 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T25. Table 3311 below describes the starting and ending position of this segment on each transcript.

Table 3311 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R17570_P15.

Segment cluster R17570_node_3 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T25. Table 3312 below describes the starting and ending position of this segment on each transcript.

Table 3312 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R17570_P15.

Segment cluster R17570_node_6 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3 and R17570_T10. Table 3313 below describes the starting and ending position of this segment on each transcript. Table 3313 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R1757O_P1 and R17570_P4.

Segment cluster R17570_node_16 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570JT3, R17570_T5 and R17570_T25. Table 3314 below describes the starting and ending position of this segment on each transcript.

Table 3314 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R17570_P2. This segment can also be found in the following protein(s): R1757O_P1 and R17570_P15, since it is in the coding region for the corresponding transcript.

Segment cluster Rl 7570_node_20 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T25. Table 3315 below describes the starting and ending position of this segment on each transcript.

Table 3315 - Segment location on transcripts

This segment can be found in the following protein(s): R17570JP1, R17570_P2, R17570_P4 and R17570_P15.

Segment cluster R17570_node_21 according to the present invention can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T25. Table 3316 below describes the starting and ending position of this segment on each transcript.

Table 3316 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2,

R17570 P4 and R17570 P15.

Segment cluster R17570_node_29 according to the present invention can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10, R17570_T24 and R17570_T25. Table 3317 below describes the starting and ending position of this segment on each transcript.

Table 3317 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2, R17570_P4, R17570_P14 and R17570_P15. Segment cluster R17570jαode_30 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10, R17570_T24 and R17570_T25. Table 3318 below describes the starting and ending position of this segment on each transcript.

Table 3318 - Segment location on transcripts

This segment can be found in the following protein(s): R17570JP1, R17570_P2, R17570_P4, R17570_P14 and R17570 P15.

Segment cluster R17570_node_32 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10, R17570_T24 and R17570_T25. Table 3319 below describes the starting and ending position of this segment on each transcript.

Table 3319 - Segment location on transcripts

This segment can be found in the following protein(s): Rl 7570 JPl, R17570_P2, R17570_P4₅ R17570JP14 and R17570JP15. Segment cluster R17570_node_36 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10, R17570_T24 and R17570_T25. Table 3320 below describes the starting and ending position of this segment on each transcript.

Table 3320 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2, R17570JP4, R17570_P14 and R17570_P15.

Segment cluster R17570_node_38 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570JD, R17570_T5, R17570_T10, R17570_T24 and R17570_T25. Table 3321 below describes the starting and ending position of this segment on each transcript.

Table 3321 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2, R17570_P4, R17570_P14 and R17570_P15. Segment cluster R17570_jiode_40 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10, R17570_T24 and R17570_T25. Table 3322 below describes the starting and ending position of this segment on each transcript.

Table 3322 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2, R17570_P4, R17570_P14 and R17570_P15.

Segment cluster R17570_node__41 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10, R17570_T24 and R17570_T25. Table 3323 below describes the starting and ending position of this segment on each transcript.

Table 3323 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570JP2, R17570_P4, R17570_P14 and R17570_P15. Segment cluster R17570_node_42 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T25. Table 3324 below describes the starting and ending position of this segment on each transcript.

Table 3324 - Segment location on transcripts

This segment can be found in the following protein(s): R17570_P15.

Segment cluster R17570_node_44 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3325 below describes the starting and ending position of this segment on each transcript.

Table 3325 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2, R17570 P4 and R17570 P14.

Segment cluster R17570_node_50 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3326 below describes the starting and ending position of this segment on each transcript.

Table 3326 - Segment location on transcripts

This segment can be found in the following protein(s): R1757O_P1, R17570_P2, R17570_P4 and R17570_P14.

Segment cluster R17570_node_54 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3327 below describes the starting and ending position of this segment on each transcript.

Table 3327 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R17570JP1, R17570_P2, R17570_P4 and R17570_P14.

Segment cluster R17570_node_55 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3328 below describes the starting and ending position of this segment on each transcript.

Table 3328 - Segment location on transcripts

Rl 7570 T24 1890 1993

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R17570JP1, R17570_P2, R17570_P4 and R17570_P14.

Segment cluster R17570_node_56 according to the present invention is supported by 59 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3329 below describes the starting and ending position of this segment on each transcript.

Table 3329 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R1757O_P1, R17570_P2, R17570_P4 and R17570_P14.

Segment cluster R17570_node_58 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3330 below describes the starting and ending position of this segment on each transcript.

Table 3330 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R1757O_P1, R17570_P2, R17570_P4 and R17570_P14. Segment cluster R17570_node_60 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R1757O_T5, R17570_T10 and R17570_T24. Table 3331 below describes the starting and ending position of this segment on each transcript.

Table 3331 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R1757O_P1, R17570_P2, R17570JP4 and R17570_P14.

Segment cluster Rl 7570_node_62 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R1757O_T5, R17570_T10 and R17570_T24. Table 3332 below describes the starting and ending position of this segment on each transcript.

Table 3332 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R1757O_P1, R17570_P2, R17570JP4 and R17570_P14.

Segment cluster R17570_node_63 according to the present invention can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3333 below describes the starting and ending position of this segment on each transcript. Table 3333 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R17570JP1, R17570_P2, R17570_P4 and R17570JP14.

Segment cluster R17570_node_65 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3334 below describes the starting and ending position of this segment on each transcript.

Table 3334 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R1757O_P1, R17570JP2, R17570_P4 and R17570_P14.

Segment cluster R17570_node_66 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R17570_T3, R17570_T5, R17570_T10 and R17570_T24. Table 3335 below describes the starting and ending position of this segment on each transcript.

Table 3335 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R17570JU, R17570JP2, R17570_P4 and R17570_P14.

DESCRIPTION FOR CLUSTER R20420

Cluster R20420 features 1 transcript(s) and 18 segment(s) of interest, the names for which are given in Tables 3336 and 3337, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3338.

Table 3336 - Transcripts of interest

TranscriptName

R20420 T2

Table3337-Segmentsofinterest

SegmentName

R20420 node 0

R20420 node 5

R20420 node 6

R20420 node 8

R20420 node 11

R20420 node 13

R20420 node 14

R20420 node 20

R20420 node 24

R20420 node 26

R20420 node 27

R20420 node 4

R20420 node 9

R20420 node 10

R20420 node 15

R20420 node 17

R20420 node 18 R20420 node 25

Table 3338 - Proteins of interest

These sequences are variants of the known protein NGFI-A binding protein 2 (SwissProt accession identifier NAB2__HUMAN; known also according to the synonyms EGR-I binding protein 2; Melanoma- associated delayed early response protein; MADER protein), referred to herein as the previously known protein.

Protein NGFI-A binding protein 2 is known or believed to have the following function(s):

Acts as a transcriptional repressor for zinc finger transcription factors EGRl and EGR2. Isoform 2 lacks repression ability (By similarity). The sequence for protein NGFI-A binding protein 2 is given at the end of the application, as "NGFI-A binding protein 2 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3339.

Table 3339 - Amino acid mutations for Known Protein

Protein NGFI-A binding protein 2 localization is believed to be Nuclear. Isoform 2 is not localized to the nucleus (By similarity).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription regulation; neurogenesis; cell proliferation, which are annotation(s) related to Biological Process; and transcription co-repressor, which are annotation(s) related to Molecular Function.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>. Cluster R20420 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 82 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 82 and Table 3340. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: skin malignancies.

Table 3340 - Normal tissue distribution

Table 3341 - P values and ratios for expression in cancerous tissue

As noted above, cluster R20420 features 18 segment(s), which were listed in Table 3337 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R20420_node_0 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcripts): R20420_T2. Table 3342 below describes the starting and ending position of this segment on each transcript.

Table 3342 - Segment location on transcripts

This segment can be found in the following ρrotein(s): R20420_P2. Segment cluster R20420_node_5 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3343 below describes the starting and ending position of this segment on each transcript.

Table 3343 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2.

Segment cluster R20420_node_6 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3344 below describes the starting and ending position of this segment on each transcript.

Table 3344 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2.

Segment cluster R20420_node_8 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3345 below describes the starting and ending position of this segment on each transcript.

Table 3345 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2. Segment cluster R20420_node_l 1 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3346 below describes the starting and ending position of this segment on each transcript.

Table 3346 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2.

Segment cluster R20420_node_l 3 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3347 below describes the starting and ending position of this segment on each transcript.

Table 3347 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2.

Segment cluster R20420_node_14 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3348 below describes the starting and ending position of this segment on each transcript.

Table 3348 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2. Segment cluster R20420_node_20 according to the present invention is supported by 56 libraπes. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3349 below describes the starting and ending position of this segment on each transcript.

Table 3349 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20420 P2.

Segment cluster R20420_node_24 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3350 below describes the starting and ending position of this segment on each transcript.

Table 3350 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R20420_P2.

Segment cluster R20420_node_26 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3351 below describes the starting and ending position of this segment on each transcript.

Table 3351 - Segment location on transcripts

R20420 T2 2590 2799

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20420_P2.

Segment cluster R20420_node_27 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3352 below describes the starting and ending position of this segment on each transcript.

Table 3352 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20420_P2.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R20420_node_4 according to the present invention can be found in the following transcript(s): R20420_T2. Table 3353 below describes the starting and ending position of this segment on each transcript.

Table 3353 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2. Segment cluster R20420_node_9 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3354 below describes the starting and ending position of this segment on each transcript.

Table 3354 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2.

Segment cluster R20420_node_10 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3355 below describes the starting and ending position of this segment on each transcript.

Table 3355 - Segment location on transcripts

This segment can be found in the following protein(s): R20420_P2.

Segment cluster R20420_node_l 5 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in ths following transcript(s): R20420_T2. Table 3356 below describes the starting and ending position of this segment on each transcript.

Table 3356 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20420_P2. Segment cluster R20420_node_l 7 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3357 below describes the starting and ending position of this segment on each transcript.

Table 3357 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20420_P2.

Segment cluster R20420_node_l 8 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3358 below describes the starting and ending position of this segment on each transcript.

Table 3358 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20420JP2.

Segment cluster R20420_node_25 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R20420_T2. Table 3359 below describes the starting and ending position of this segment on each transcript.

Table 3359 - Segment location on transcripts

I R20420 T2 I 2484 | 2589 |

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R20420_P2.

DESCRIPTION FOR CLUSTER R34204

Cluster R34204 features 1 transcript(s) and 6 segment(s) of interest, the names for which are given in Tables 3360 and 3361, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3362. Table 3360 - Transcripts of interest

Transcript Name

R34204 T20

Table 3361 - Segments of interest

Segment Name

R34204 node 33

R34204 node 34

R34204 node 38

R34204 node 45

R34204 node 46

R34204 node 40

Table 3362 - Proteins of interest

Cluster R34204 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 83 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 83 and Table 3363. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues, gastric carcinoma and uterine malignancies.

Table 3363 - Normal tissue distribution

Table 3364 - P values and ratios for expression in cancerous tissue

As noted above, cluster R34204 features 6 segment(s), which were listed in Table 3361 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R34204_node_33 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34204_T20. Table 3365 below describes the starting and ending position of this segment on each transcript.

Table 3365 - Segment location on transcripts

This segment can be found in the following protein(s): R34204_P16.

Segment cluster R34204jtiode_34 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34204_T20. Tabb 3366 below describes the starting and ending position of this segment on each transcript.

Table 3366 - Segment location on transcripts

This segment can be found in the following protein(s): R34204_P16.

Segment cluster R34204_node_38 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34204_T20. Table 3367 below describes the starting and ending position of this segment on each transcript.

Table 3367 - Segment location on transcripts

This segment can be found in the following protein(s): R34204_P16.

Segment cluster R34204_node_45 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34204_T20. Table 3368 below describes the starting and ending position of this segment on each transcript.

Table 3368 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R34204_P16.

Segment cluster R34204_node_46 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34204_T20. Table 3369 below describes the starting and ending position of this segment on each transcript.

Table 3369 - Segment location on transcripts

R34204 T20 2336 3135

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R34204JP16.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R34204_node_40 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34204_T20. Table 3370 below describes the starting and ending position of this segment on each transcript.

Table 3370 - Segment location on transcripts

This segment can be found in the following protein(s): R34204_P16.

DESCRIPTION FOR CLUSTER R52151

Cluster R52151 features 2 transcript(s) and 24 segment(s) of interest, the names for which are given in Tables 3371 and 3372, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3373. Table 3371 - Transcripts of interest

Transcript Name

R52151 T24

R52151 T35 Table 3372 - Segments of interest

SegmentName

R52151 node 0

R52151 node 7

R52151 node 8

R52151 node 12

R52151 node 13

R52151 node 18

R52151 node 29

R52151 node 34

R52151 node 44

R52151 node 46

R52151 node 9

R52151 node 14

R52151 node 16

R52151 node 17

R52151 node 22

R52151 node 23

R52151 node 25

R52151 node 27

R52151 node 31

R52151 node 33

R52151 node 36

R52151 node 39

R52151 node 40

R52151 node 47

Table 3373 - Proteins of interest

These sequences are variants of the known protein Synaptotagmin-like protein 1 (SwissProt accession identifier STL1_HUMAN; known also according to the synonyms Exophilin 7; JFCl protein; SB 146), referred to herein as the previously known protein.

Protein Synaptotagmin-like protein 1 is known or believed to have the following function(s): May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-triphosphate. The sequence for protein Synaptotagmin-like protein 1 is given at the end of the application, as "Synaptotagmin-like protein 1 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3374.

Table 3374 -Amino acid mutations for Known Protein

Protein Synaptotagmin-like protein 1 localization is believed to be Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transport, which are annotation(s) related to Biological Process; transporter, which are annotation(s) related to Molecular Function; and synaptic vesicle; membrane, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster R52151 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 84 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 84 and Table 3375. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: prostate cancer.

Table 3375 - Normal tissue distribution

Table 3376 - P values and ratios for expression in cancerous tissue

As noted above, cluster R52151 features 24 segment(s), which were listed in Table 3372 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R52151_node_0 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T35. Table 3377 below describes the starting and ending position of this segment on each transcript.

Table 3377 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R52151_P27.

Segment cluster R52151_node_7 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3378 below describes the starting and ending position of this segment on each transcript.

Table 3378 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R52151_P19. Segment cluster R52151_node_8 according to the present invention is supported by 69 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): R52151_T24 and R52151_T35. Table 3379 below describes the starting and ending position of this segment on each transcript.

Table 3379 - Segment location on transcripts

This segment can be found in both coding and non-coding Kgions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R52151_P19. This segment can also be found in the following protein(s): R52151_P27, since it is in the coding region for the corresponding transcript.

Segment cluster R52151_node_12 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24 and R52151_T35. Table 3380 below describes the starting and ending position of this segment on each transcript.

Table 3380 - Segment location on transcripts

This segment can be found in the following protein(s): R52151JP19 and R52151_P27.

Segment cluster R52151_node_13 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3381 below describes the starting and ending position of this segment on each transcript.

Table 3381 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_18 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T35. Table 3382 below describes the starting and ending position of this segment on each transcript.

Table 3382 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P27.

Segment cluster R52151_node_29 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3383 below describes the starting and ending position of this segment on each transcript.

Table 3383 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_34 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3384 below describes the starting and ending position of this segment on each transcript.

Table 3384 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_44 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3385 below describes the starting and ending position of this segment on each transcript.

Table 3385 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_46 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3386 below describes the starting and ending position of this segment on each transcript.

Table 3386 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster R52151_node_9 according to the present invention can be found in the following transcript(s): R52151_T24 and R52151_T35. Table 3387 below describes the starting and ending position of this segment on each transcript.

Table 3387 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R52151_P19. This segment can also be found in the following protein(s): R52151_P27, since it is in the coding region for the corresponding transcript.

Segment cluster R52151_node_14 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24 and R52151_T35. Table 3388 below describes the starting and ending position of this segment on each transcript.

Table 3388 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19 and R52151JP27.

Segment cluster R52151_node_16 according to the present invention can be found in the following transcript(s): R52151_T24 and R52151_T35. Table 3389 below describes the starting and ending position of this segment on each transcript.

Table 3389 - Segment location on transcripts

R52151 T35 826 845

This segment can be found in the following protein(s): R52151_P19 and R52151_P27.

Segment cluster R52151_node_17 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24 and R52151_T35. Table 3390 below describes the starting and ending position of this segment on each transcript.

Table 3390 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19 and R52151_P27.

Segment cluster R52151_node_22 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3391 below describes the starting and ending position of this segment on each transcript.

Table 3391 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_23 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): R52151_T24. Table 3392 below describes the starting and ending position of this segment on each transcript.

Table 3392 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_25 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3393 below describes the starting and ending position of this segment on each transcript.

Table 3393 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_27 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3394 below describes the starting and ending position of this segment on each transcript.

Table 3394 - Segment location on transcripts

This segment can be found in the following protein(s): R52151JP19.

Segment cluster R52151_node_31 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3395 below describes the starting and ending position of this segment on each transcript.

Table 3395 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_33 according to the present invention can be found in the following transcript(s): R52151_T24. Table 3396 below describes the starting and ending position of this segment on each transcript.

Table 3396 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_36 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3397 below describes the starting and ending position of this segment on each transcript.

Table 3397 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_39 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3398 below describes the starting and ending position of this segment on each transcript.

Table 3398 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_40 according to the present invention can be found in the following transcript(s): R52151_T24. Table 3399 below describes the starting and ending position of this segment on each transcript.

Table 3399 - Segment location on transcripts

This segment can be found in the following protein(s): R52151_P19.

Segment cluster R52151_node_47 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R52151_T24. Table 3400 below describes the starting and ending position of this segment on each transcript. Table 3400 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R52151_P19.

DESCRIPTION FOR CLUSTER R82331 Cluster R82331 features 52 transcript(s) and 74 segment(s) of interest, the names for which are given in Tables 3401 and 3402, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3403.

Table 3401 - Transcripts of interest

TranscriptName

R82331 TO

R82331 Tl

R82331_ _T2

R82331 T3

R82331 T5

R82331 T7

R82331 T9

R82331 TlO

R82331 TIl

R82331 T13

R82331 T15

R82331 T16

R82331 T17

R82331 T18

R82331 T19

R82331 T20

R82331 T21

R82331 T22

R82331 T23

R82331 T24

R82331 T25

R82331 T26

R82331 T27

R82331 T28

R82331 T29

R82331 T30

R82331 T31

R82331 T32

R82331 T34

R82331 T35

R82331 T36

R82331 T37

R82331 T38

R82331 T39

R82331 T51

R82331 T53

Table3402-Segmentsofinterest

R82331 node 84

R82331 node 94

R82331 node 100

R82331 node 106

R82331 node 107

R82331 node 109

Table 3403 -Proteins of interest

Cluster R82331 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 85 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 85 and Table 3404. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, ovarian carcinoma, skin malignancies and uterine malignancies. Table 3404 - Normal tissue distribution

Table 3405 - P values and ratios for expression in cancerous tissue

As noted above, cluster R82331 features 74 segment(s), which were listed in Table 3402 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R8233 l_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3406 below describes the starting and ending position of this segment on each transcript.

Table 3406 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7. Segment cluster R8233 l_node_4 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3407 below describes the starting and ending position of this segment on each transcript.

Table 3407 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R82331_node_12 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13,

R82331_T53, R82331_T55 and R82331_T90. Table 3408 below describes the starting and ending position of this segment on each transcript.

Table 3408 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R82331_node_19 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3409 below describes the starting and ending position of this segment on each transcript.

Table 3409 - Segment location on transcripts

This segment can be found in the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R8233 l_node_20 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13,

R82331_T53, R82331_T55 and R82331_T90. Table 3410 below describes the starting and ending position of this segment on each transcript.

Table 3410 - Segment location on transcripts

R82331 T90 4157 4700

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R82331_node_21 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3411 below describes the starting and ending position of this segment on each transcript.

Table 3411 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R82331_node_23 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T10 and R82331_T55. Table 3412 below describes the starting and ending position of this segment on each transcript.

Table 3412 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2.

Segment cluster R82331_node_26 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously descπbed. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3413 below describes the starting and ending position of this segment on each transcript.

Table 3413 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R82331_node_27 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331 T9, R82331_T10, R82331_T11, R82331_T13,

R82331_T53, R82331_T55 and R82331_T90. Table 3414 below describes the starting and ending position of this segment on each transcript.

Table 3414 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R82331_node_28 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T53 and R82331_T55. Table 3415 below describes the starting and ending position of this segment on each transcript.

Table 3415 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP7 and R82331JP2.

Segment cluster R82331_node_30 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T51, R82331_T56, R82331_T59, R82331_T69, R82331_T72, R82331_T74, R82331_T76, R82331_T79, R82331_T80, R82331_T84, R82331_T86, R82331_T89 and R82331_T92. Table 3416 below describes the starting and ending position of this segment on each transcript.

Table 3416 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1 and R82331JP6.

Segment cluster R82331_node_32 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T51, R82331_T56, R82331_T59, R82331_T69, R82331_T72, R82331_T74, R82331_T76, R82331_T79, R82331_T80, R82331_T84, R82331_T86, R82331_T89 and R82331_T92. Table 3417 below describes the starting and ending position of this segment on each transcript.

Table 3417 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1 and R82331_P6.

Segment cluster R82331_node_33 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T51, R82331_T56, R82331_T59, R82331_T69, R82331_T72, R82331_T74, R82331_T76, R82331_T79, R82331_T80, R82331_T84, R82331_T86, R82331_T89, R82331_T90 and R82331_T92. Table 3418 below describes the starting and ending position of this segment on each transcript.

Table 3418 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P2 and R82331_P6.

Segment cluster R82331_node_35 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T51, R82331_T56, R82331_T59, R82331_T69, R82331_T72, R82331_T74, R82331_T76, R82331_T79, R82331_T80 and R82331_T84. Table 3419 below describes the starting and ending position of this segment on each transcript. Table 3419 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331 JPl, R82331_P2 and R82331_P6.

Segment cluster R82331_node_38 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T28. Table 3420 below describes the starting and ending position of this segment on each transcript. Table 3420 - Segment location on transcripts

R82331 T28 U 556

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1.

Segment cluster R82331_node_41 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T84. Table 3421 below describes the starting and ending position of this segment on each transcript.

Table 3421 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R8233 l_node_43 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T51, R82331_T59, R82331_T79 and R82331_T92. Table 3422 below describes the starting and ending position of this segment on each transcript.

Table 3422 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R82331_node__44 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T51 and R82331_T59. Table 3423 below describes the starting and ending position of this segment on each transcript.

Table 3423 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R82331_node_47 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T69 and R82331_T86. Table 3424 below describes the starting and ending position of this segment on each transcript.

Table 3424 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R8233 l_node_49 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. TMs segment can be found in the following transcript(s): R82331_T79. Table 3425 below describes the starting and ending position of this segment on each transcript.

Table 3425 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster R82331_node_59 according to the present invention is supported by 20 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): R82331_T72, R82331_T76, R82331_T79, R82331_T89, R82331_T90 and R82331_T92. Table 3426 below describes the starting and ending position of this segment on each transcript.

Table 3426 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2.

Segment cluster R82331_node_61 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T21, R82331_T25, R82331_T26, R82331_T27, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T39. Table 3427 below describes the starting and ending position of this segment on each transcript.

Table 3427 - Segment location on transcripts

This segment can be found in the following protein(s): R82331_P4.

Segment cluster R8233 l_node_63 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T20. Table 3428 below describes the starting and ending position of this segment on each transcript.

Table 3428 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P1.

Segment cluster R82331_node_71 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T23. Table 3429 below describes the starting and ending position of this segment on each transcript.

Table 3429 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R8233 IJPl . Segment cluster R82331_node_78 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T24. Table 3430 below describes the starting and ending position of this segment on each transcript.

Table 3430 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1.

Segment cluster R82331_node_83 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T2, R82331_T21 and R82331_T24. Table 3431 below describes the starting and ending position of this segment on each transcript.

Table 3431 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P1 and R82331_P4.

Segment cluster R82331_node_85 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T1, R82331_T2, R82331_T3, R82331_T16,

R82331_T18, R82331_T19, R82331_T21, R82331_T23, R82331_T24, R82331_T25,

R82331_T26, R82331_T27, R82331_T29, R82331_T30, R82331_T34, R82331_T35,

R82331_T37, R82331_T38, R82331_T39, R82331_T74 and R82331_T80. Table 3432 below describes the starting and ending position of this segment on each transcript. Table 3432 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P4 and R82331_P6.

Segment cluster R82331_node_89 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T60 and R82331_T66. Table 3433 below describes the starting and ending position of this segment on each transcript.

Table 3433 - Segment location on transcripts

This segment can be found in the following protein(s): R82331_P5.

Segment cluster R82331_node_90 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T60 and R82331_T66. Table 3434 below describes the starting and ending position of this segment on each transcript.

Table 3434 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331JP5.

Segment cluster R82331_node_91 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T60 and R82331_T66. Table 3435 below describes the starting and ending position of this segment on each transcript.

Table 3435 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P5.

Segment cluster R82331_node_93 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T22. Table 3436 below describes the starting and ending position of this segment on each transcript. Table 3436 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster R82331_node_95 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following traiBcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38, R82331_T56, R82331_T74 and R82331_T80. Table 3437 below describes the starting and ending position of this segment on each transcript.

Table 3437 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2 and R82331JP4. This segment can also be found in the following protein(s): R82331_P6, since it is in the coding region for the corresponding transcript.

Segment cluster R82331_node_96 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T56. Table 3438 below describes the starting and ending position of this segment on each transcript.

Table 3438 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2 and R82331_P4.

Segment cluster R82331_node_97 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T56. Table 3439 below describes the starting and ending position of this segment on each transcript.

Table 3439 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2 and R82331_P4. Segment cluster R82331_node__98 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T56. Table 3440 below describes the starting and ending position of this segment on each transcript. Table 3440 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P2 and R82331_P4.

Segment cluster R82331_node_99 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T56. Table 3441 below describes the starting and ending position of this segment on each transcript.

Table 3441 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331 _P2 and R82331_P4.

Segment cluster R82331_node_101 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_ T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36₃ R82331_T37, R82331_T38, R82331_T39 and R82331_T56. Table 3442 below describes the starting and ending position of this segment on each transcript.

Table 3442 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P2 and R82331_P4.

Segment cluster R82331_node_102 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T39. Table 3443 below describes the starting and ending position of this segment on each transcript.

Table 3443 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P2 and R82331JP4.

Segment cluster R82331_node_103 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T39. Table 3444 below describes the starting and ending position of this segment on each transcript.

Table 3444 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331 JPl, R82331_P2 and R82331_P4.

Segment cluster R82331_node_104 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T39. Table 3445 below describes the starting and ending position of this segment on each transcript.

Table 3445 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P4. This segment can also be found in the following protein(s): R82331_P1, since it is in the coding region for the corresponding transcript.

Segment cluster R82331_node_105 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331JN, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_ T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T39. Table 3446 below describes the starting and ending position of this segment on each transcript.

Table 3446 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P2 and R82331_P4.

Segment cluster R82331_node_ 108 according to the present invention is supported by 56 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R8233 I_TlO, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331__T39. Table 3447 below describes the starting and ending position of this segment on each transcript.

Table 3447 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P2 and R82331_P4.

Segment cluster R82331_node_110 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38, R82331_T39, R82331_T56, R82331_T74 and R82331_T80. Table 3448 below describes the starting and ending position of this segment on each transcript. Table 3448 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2 and R82331_P4. This segment can also be found in the following protein(s): R82331_P6, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster R82331_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3449 below describes the starting and ending position of this segment on each transcript.

Table 3449 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331JP7.

Segment cluster R82331_node__6 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3450 below describes the starting and ending position of this segment on each transcript.

Table 3450 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331JP7.

Segment cluster R82331_node_8 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3451 below describes the starting and ending position of this segment on each transcript.

Table 3451 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R82331_node_10 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3452 below describes the starting and ending position of this segment on each transcript.

Table 3452 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331JP2 and R82331_P7.

Segment cluster R82331_node_14 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T55 and R82331_T90. Table 53 below describes the starting and ending position of this segment on each transcript. Table 3453 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2.

Segment cluster R82331_node_16 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T9, R8233 l_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3454 below describes the starting and ending position of this segment on each transcript. Table 3454 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P7. This segment can also be found in the following protein(s): R82331JP2, since it is in the coding region for the corresponding transcript.

Segment cluster R82331_node_17 according to the present invention can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T53, R82331_T55 and R82331_T90. Table 3455 below describes the starting and ending position of this segment on each transcript.

Table 3455 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP7. This segment can also be found in the following protein(s): R82331_P2, since it is in the coding region for the corresponding transcript.

Segment cluster R82331_node_22 according to the present invention can be found in the following transcript(s): R82331_T10, R82331_T53 and R82331_T55. Table 3456 below describes the starting and ending position of this segment on each transcript. Table 3456 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2 and R82331_P7.

Segment cluster R82331_node_24 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R8233 I_TlO and R82331_T55. Table 3457 below describes the starting and ending position of this segment on each transcript.

Table 3457 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2.

Segment cluster R82331_node_25 according to the present invention can be found in the following transcript(s): R82331_T9, R82331_T10, R82331_T13, R82331_T55 and R82331_T90. Table 58 below describes the starting and ending position of this segment on each transcript.

Table 3458 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2.

Segment cluster R82331_node_31 according to the present invention can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T51, R82331_T56, R82331_T59, R82331_T69, R82331_T72, R82331_T74, R82331_T76, R82331_T79, R82331_T80, R82331_T84, R82331_T86, R82331_T89 and R82331_T92. Table 3459 below describes the starting and ending position of this segment on each transcript.

Table 3459 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1 and R82331JP6.

Segment cluster R82331_node_39 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T28, R82331_T51, R82331_T56, R82331_T59, R82331_T69, R82331_T72, R82331_T74, R82331_T76, R82331_T79, R82331_T80, R82331_T84, R82331_T86, R82331_T89, R82331_T90 and R82331_T92. Table 3460 below describes the starting and ending position of this segment on each transcript.

Table 3460 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P2 and R82331_P6.

Segment cluster R82331_node_53 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T72, R82331_T76, R82331_T79, R82331_T89, R82331_T90 and R82331_T92. Table 3461 below describes the starting and ending position of this segment on each transcript.

Table 3461 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2.

Segment cluster R82331_node_54 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T72, R82331_T76, R82331_T79, R82331_T89, R82331_T90 and R82331_T92. Table 3462 below describes the starting and ending position of this segment on each transcript.

Table 3462 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P2.

Segment cluster R82331_node_55 according to the present invention can be found in the following transcript(s): R82331_T72, R82331_T76, R82331_T79, R82331_T89, R82331_T90 and R82331_T92. Table 3463 below describes the starting and ending position of this segment on each transcript.

Table 3463 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331JP2.

Segment cluster R82331_node_57 according to the present invention can be found in the following transcriρt(s): R82331_T72, R82331_T76, R82331_T79, R82331_T89, R82331_T90 and R82331_T92. Table 3464 below describes the starting and ending position of this segment on each transcript.

Table 3464 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P2.

Segment cluster R82331_node_64 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21 , R82331_T25, R82331_T27, R82331_T28, R82331_T31, R82331_T35, R82331_T39, R82331_T56, R82331_T74 and R82331_T80. Table 3465 below describes the starting and ending position of this segment on each transcript.

Table 3465 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2, R82331_P4 and R82331JP6.

Segment cluster R82331_node_65 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R8233 I_TlO, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T25, R82331_T27, R82331_T28, R82331_T31, R82331_T39, R82331_T56, R82331_T74 and R82331_T80. Table 3466 below describes the starting and ending position of this segment on each transcript.

Table 3466 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2, R82331J^>4 and R82331_P6.

Segment cluster R82331_node_72 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T17, R82331_T20, R82331_T21, R82331_T23, R82331_T26, R82331_T27, R82331_T28, R82331_T30, R82331_T35, R82331_T39 and R82331_T56. Table 3467 below describes the starting and ending position of this segment on each transcript.

Table 3467 - Segment location on transcripts

This segment can be fcund in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331 _P2 and R82331_P4.

Segment cluster R8233 l_node_73 according to the present invention can be found in the following transcript(s): R82331_T0, R82331JU, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T23, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T30, R82331_T32, R82331_T34, R82331_T35, R82331_T39, R82331_T56, R82331_T74 and R82331_T80. Table 3468 below describes the starting and ending position of this segment on each transcript.

Table 3468 ~ Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331_P2, R82331J^>4 and R82331_P6.

Segment cluster R82331_node_74 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T23, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T39, R82331_T56, R82331_T74 and R82331_T80. Table 3469 below describes the starting and ending position of this segment on each transcript.

Table 3469 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1, R82331JP2, R82331_P4 and R82331JP6.

Segment cluster R82331_node_76 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T23, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T39, R82331_T56, R82331_T74 and R82331_T80. Table 3470 below describes the starting and ending position of this segment on each transcript.

Table 3470 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2, R82331_P4 and R82331_P6.

Segment cluster R82331_node_80 according to the present invention can be found in the following transcript(s): R82331_T1, R82331_T2, R82331_T16, R82331_T18, R82331_T19, R82331_T21, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T29, R82331_T34, R82331_T35, R82331 T37, R82331_T38, R82331_T74 and R82331_T80. Table 3471 below describes the starting and ending position of this segment on each transcript. Table 3471 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331 __P1, R82331_P4 and R82331_P6.

Segment cluster R82331_node_81 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T1, R82331_T2, R82331_T3, R82331_T16, R82331_T18, R82331_T19, R82331_T21, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T29, R82331_T30, R82331_T34, R82331_T35, R82331_T37, R82331_T38, R82331_T39, R82331_T74 and R82331_T80. Table 3472 below describes the starting and ending position of this segment on each transcript.

Table 3472 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P4 and R82331JP6.

Segment cluster R82331_node_82 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T1, R82331_T2, R82331_T3, R82331_T16,

R82331_T18, R82331_T19, R82331_T21, R82331_T23, R82331_T24, R82331_T25,

R82331_T26, R82331_T27, R82331_T29, R82331_T30, R82331_T34, R82331_T35, R82331_T37, R82331_T38, R82331_T39, R82331_T74 and R82331_T80. Table 3473 below describes the starting and ending position of this segment on each transcript.

Table 3473 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P4 and R82331_P6.

Segment cluster R82331_node_84 according to the present invention can be found in the following transcript(s): R82331_T2, R82331_T3, R82331_T21, R82331_T24 and R82331_T38. Table 3474 below describes the starting and ending position of this segment on each transcript.

Table 3474 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331JP1 and R82331JP4.

Segment cluster R82331_node__94 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38, R82331_T39, R82331_T56, R82331_T74 and R82331_T80. Table 3475 below describes the starting and ending position of this segment on each transcript. Table 3475 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2, R82331_P4 and R82331_P6.

Segment cluster R82331_node_100 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38, R82331_T39 and R82331_T56. Table 3476 below describes the starting and ending position of this segment on each transcript.

Table 3476 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2 and R82331_P4.

Segment cluster R82331_node_106 according to the present invention can be found in the following transcript(s): R82331_T0, R82331JN, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_ T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T39. Table 3477 below describes the starting and ending position of this segment on each transcript.

Table 3477 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2 and R82331_P4.

Segment cluster R82331_node_107 according to the present invention can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R8233 l_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38 and R82331_T39. Table 3478 below describes the starting and ending position of this segment on each transcript.

Table 3478 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2 and R82331_P4.

Segment cluster R82331_node_109 according to the present invention can be found in the following transcript(s): R82331_T0, R82331_T1, R82331_T2, R82331_T3, R82331_T5, R82331_T7, R82331_T9, R82331_T10, R82331_T11, R82331_T13, R82331_T15, R82331_T16, R82331_T17, R82331_T18, R82331_T19, R82331_T20, R82331_T21, R82331_T22, R82331_T23, R82331_T24, R82331_T25, R82331_T26, R82331_T27, R82331_T28, R82331_T29, R82331_T30, R82331_T31, R82331_T32, R82331_T34, R82331_T35, R82331_T36, R82331_T37, R82331_T38, R82331_T39, R82331_T74 and R82331_T80. Table 3479 below describes the starting and ending position of this segment on each transcript.

Table 3479 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R82331_P1, R82331_P2 and R82331_P4. This segment can also be found in the following protein(s): R82331_P6, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER T06117 Cluster T06117 features 6 transcript(s) and 39 segment(s) of interest, the names for which are given in Tables 3480 and 3481, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3482.

Table 3480 - Transcripts of interest

TranscriptName

T06117 T7

T06117 T16

T06117 T30

T06117 T31

T06117 T42

T06117 T45

Table3481-Segmentsofinterest

SegmentNaetu

T06117 node 0

T06117 node 14

T06117 node 18

T06117 node 22

T06117 node 25

T06117 node 27

T06117 node 28

T06117 node _30

T06117 node 31

T06117 node 36

T06117 node 53

T06117 node 60

T06117 node 69

T06117 node 71

T06117 node 74

T06117 node 2

T06117 node 8

T06117 node 11

T06117 node 16

T06117 node 17

T06117 node 19

T06117 node 20

T06117 node 32

T06117 node 33

Table 3482 - Proteins of interest

Cluster T06117 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 86 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 86 and Table 3483. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: a mixture of malignant tumors from different tissues. Table 3483 - Normal tissue distribution

Table 3484 - P values and ratios for expression in cancerous tissue

As noted above, cluster T06117 features 39 segment(s), which were listed in Table 3481 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T06117_node_0 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 6 below describes the starting and ending position of this segment on each transcript.

Table 3485 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8. This segment can also be found in the following protein(s): T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript. Segment cluster T06117_node_14 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 7 below describes the starting and ending position of this segment on each transcript.

Table 3486 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8. This segment can also be found in the following protein(s):

T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript.

Segment cluster T06117_node_18 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7. Table 3487 below describes the starting and ending position of this segment on each transcript.

Table 3487 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8. Segment cluster T061 17_node_22 according to the present invention is supported by 53 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 9 below describes the starting and ending position of this segment on each transcript.

Table 3488 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P27, T06117_P28, T06117_P39 and T06117_P42.

Segment cluster T06117_node_25 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31 and T06117_T42. Table 3489 below describes the starting and ending position of this segment on each transcript

Table 3489 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P27, T06117 P28 and T06117 P39.

Segment cluster T06117_node_27 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T061 17_T30, T061 17_T31, T06117_T42 and T06117_T45. Table 11 below describes the starting and ending position of this segment on each transcript.

Table 3490 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P27, T06117JP28, T06117_P39 and T06117JP42.

Segment cluster T06117_node_28 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T42 and T06117_T45. Table 3491 below describes the starting and ending position of this segment on each transcript.

Table 3491 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P39 and T06117_P42.

Segment cluster T06117_node_30 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T16. Table 3492 below describes the starting and ending position of this segment on each transcript.

Table 3492 - Segment location on transcripts

This segment can be found in the following protein(s): T06117JP 16.

Segment cluster T06117_node_31 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T16. Table 3493 below describes the starting and ending position of this segment on each transcript.

Table 3493 - Segment location on transcripts

This segment can be found in the following protein(s): T06117JP16.

Segment cluster T06117_node_36 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3494 below describes the starting and ending position of this segment on each transcript.

Table 3494 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117JP27 and T06117_P28.

Segment cluster T06117_node_53 according to the present invention is supported by 95 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T061 17_T16, T061 17_T30 and T061 17_T31. Table 3495 below describes the starting and ending position of this segment on each transcript.

Table 3495 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117 P27 and T06117 P28.

Segment cluster T06117_node_60 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3496 below describes the starting and ending position of this segment on each transcript.

Table 3496 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117 P27 and T06117 P28.

Segment cluster T06117_node_69 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T30 and T06117_T31. Table 3497 below describes the starting and ending position of this segment on each transcript.

Table 3497 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P28. This segment can also be found in the following protein(s): T06117_P27, since it is in the coding region for the corresponding transcript.

Segment cluster T06117_node_71 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3498 below describes the starting and ending position of this segment on each transcript.

Table 3498 - Segment location on transcripts

This segment can be found in both coding and non-coding iegions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117JP27 and T06117_P28. This segment can also be found in the following protein(s): T06117_P8 and T06117_P16, since it is in the coding region for the corresponding transcript.

Segment cluster T06117_node_74 according to the present invention is supported by 122 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3499 below describes the starting and ending position of this segment on each transcript.

Table 3499 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8, T06117JP16, T06117_P27 and T06117_P28.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T06117_node_2 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 21 below describes the starting and ending position of this segment on each transcript. Table 3500 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117JP8. This segment can also be found in the following protein(s): T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript. Segment cluster T06117_node_8 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31 , T06117_T42 and T06117_T45. Table 22 below describes the starting and ending position of this segment on each transcript.

Table 3501 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117 P8. This segment can also be found in the following protein(s):

T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript.

Segment cluster T06117_node_l l according to the present invention is supported by 75 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 23 below describes the starting and ending position of this segment on each transcript. Table 3502 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8. This segment can also be found in the following protein(s): T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript.

Segment cluster T06117_node_16 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 24 below describes the starting and ending position of this segment on each transcript.

Table 3503 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8. This segment can also be found in the following protein(s): T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript.

Segment cluster T06117_node_17 according to the present invention can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 25 below describes the starting and ending position of this segment on each transcript.

Table 3504 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8. This segment can also be found in the following protein(s): T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript.

Segment cluster T06117_node_19 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 26 below describes the starting and ending position of this segment on each transcript.

Table 3505 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8. This segment can also be found in the fallowing protein(s): T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript Segment cluster T06117jnode_20 according to the present invention can be found in the following transcript(s): T061 17_T7, T06117_T30, T06117_T31, T06117_T42 and T06117_T45. Table 27 below describes the starting and ending position of this segment on each transcript.

Table 3506 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8. This segment can also be found in the following protein(s): T06117_P27, T06117_P28, T06117_P39 and T06117_P42, since it is in the coding region for the corresponding transcript.

Segment cluster T06117_node_32 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3507 below describes the starting and ending position of this segment on each transcript.

Table 3507 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117 P27 and T06117 P28. Segment cluster T06117_node_33 according to the present invention is supported by 39 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3508 below describes the starting and ending position of this segment on each transcript.

Table 3508 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117_P27 and T06117_P28.

Segment cluster T06117_node_39 according to the present invention is supported by 71 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117JI30 and T06117_T31. Table 3509 below describes the starting and ending position of this segment on each transcript.

Table 3509 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117 P27 and T06117 P28.

Segment cluster T06117_node_40 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3510 below describes the starting and ending position of this segment on each transcript. Table 3510 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117_P27 and T06117_P28.

Segment cluster T06117_node_41 according to the present invention can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3511 below describes the starting and ending position of this segment on each transcript.

Table 3511 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117 P27 and T06117 P28.

Segment cluster T06117_node_42 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3512 below describes the starting and ending position of this segment on each transcript.

Table 3512 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117_P27 and T06117_P28.

Segment cluster T06117_node_43 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3513 below describes the starting and ending position of this segment on each transcript.

Table 3513 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117 P27 and T06117 P28.

Segment cluster T06117_node_44 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3514 below describes the starting and ending position of this segment on each transcript.

Table 3514 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117 P27 and T06117 P28. Segment cluster T06117_node_45 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3515 below describes the starting and ending position of this segment on each transcript.

Table 3515 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117_P27 and T06117_P28.

Segment cluster T06117_node_47 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3516 below describes the starting and ending position of this segment on each transcript.

Table 3516 - Segment location on transcripts

This segment can be found in the following ρrotein(s): T06117_P8, T06117JP16, T06117_P27 and T06117_P28.

Segment cluster T06117_node_49 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T061 17_T31. Table 3517 below describes the starting and ending positbn of this segment on each transcript.

Table 3517 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117JP16, T06117 P27 and T06117 P28.

Segment cluster T06117_node_55 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3518 below describes the starting and ending position of this segment on each transcript.

Table 3518 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117 P27 and T06117 P28.

Segment cluster T06117_node_57 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3519 below describes the starting and ending position of this segment on each transcript.

Table 3519 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117_P16, T06117_P27 and T06117_P28.

Segment cluster T06117_node_62 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3520 below describes the starting and ending position of this segment on each transcript.

Table 3520 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P8, T06117JP16, T06117 P27 and T06117 P28.

Segment cluster T06117_node_65 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3521 below describes the starting and ending position of this segment on each transcript.

Table 3521 - Segtnent location on transcripts

T06117 T31 3064 3108

This segment can be found in the following protein(s): T06117JP8, T06117_P16, T06117_P27 and T061 17_P28.

Segment cluster T06117_node_68 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T31. Table 3522 below describes the starting and ending position of this segment on each transcript.

Table 3522 - Segment location on transcripts

This segment can be found in the following protein(s): T06117_P28.

Segment cluster T06117_node_72 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T06117_T7, T06117_T16, T06117_T30 and T06117_T31. Table 3523 below describes the starting and ending position of this segment on each transcript.

Table 3523 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T06117_P8, T06117JP16, T06117_P27 and T06117_P28.

DESCRIPTION FOR CLUSTER T10374 Cluster Tl 0374 features 3 transcript(s) and 26 segment(s) of interest, the names for which are given in Tables 3524 and 3525, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3526.

Table 3524 - Transcripts of interest

TranscriptName

Tl0374 T16

Tl0374 T24

T10374 T27

Table3525-Segmentsofinterest

Table 3526 - Proteins of interest

Cluster T 10374 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 87 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 87 and Table 3527. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: ovarian carcinoma.

Table 3527 - Normal tissue distribution

Table 3528 - P values and ratios for expression in cancerous tissue

As noted above, cluster Tl 0374 features 26 segment(s), which were listed in Table 3525 above and fer which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster T10374_node_2 according to the present invention is supported by 3 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3529 below describes the starting and ending position of this segment on each transcript.

Table 3529 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374_P2, T10374_P6 and T10374_P9.

Segment cluster T10374_node_3 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3530 below describes the starting and ending position of this segment on each transcript. Table 3530 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T10374_P2, T10374_P6 and T10374_P9.

Segment cluster T10374_node_19 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3531 below describes the starting and ending position of this segment on each transcript. Table 3531 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374_P2 and T10374JP9. This segment can also be found in the following protein(s): T10374_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T10374_node_27 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16 and T10374_T27. Table 3532 below describes the starting and ending position of this segment on each transcript.

Table 3532 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374_P2 and T10374_P9.

Segment cluster T10374_node_51 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3533 below describes the starting and ending position of this segment on each transcript.

Table 3533 - Segment location on transcripts

This segment can be found in the following protein(s): T10374__P2, T10374_P6 and T10374 P9.

Segment cluster T10374_node_57 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T24 and T10374_T27. Table 3534 below describes the starting and ending position of this segment on each transcript.

Table 3534 - Segment location on transcripts

This segment can be found in the following protein(s): T10374_P6 and T10374JP9.

Segment cluster T10374_node_60 according to the present invention is supported by 276 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16. Table 3535 below describes the starting and ending position of this segment on each transcript.

Table 3535 - Segment location on transcripts

This segment can be found in the following protein(s): T10374JP2.

Segment cluster T10374_node_63 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16. Table 3536 below describes the starting and ending position of this segment on each transcript.

Table 3536 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T10374_P2.

Segment cluster T10374_node_65 according to the present invention is supported by 330 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16. Table 3537 below describes the starting and ending position of this segment on each transcript.

Table 3537 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Tl 0374_P2.

Segment cluster T10374_node_67 according to the present invention is supported by 157 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16. Table 3538 below describes the starting and ending position of this segment on each transcript.

Table 3538 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374JP2. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T10374_node_16 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3539 below describes the starting and ending position of this segment on each transcript.

Table 3539 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T10374_P2, T10374_P6 and T10374_P9.

Segment cluster T10374_node_23 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3540 below describes the starting and ending position of this segment on each transcript. Table 3540 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as /s. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374JP2 and T10374_P9. This segment can also be found in the following protein(s): T10374_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T10374_node_25 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3541 below describes the starting and ending position of this segment on each transcript.

Table 3541 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374_P2 and T10374_P9. This segment can also be found in the following protein(s): T10374_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T10374_node_29 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3542 below describes the starting and ending position of this segment on each transcript.

Table 3542 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374_P2 and T10374_P9. This segment can also be found in the following protein(s): T10374JP6, since it is in the coding region for the corresponding transcript.

Segment cluster T10374_node_31 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3543 below describes the starting and ending position of this segment on each transcript.

Table 3543 - Segment location on transcripts

This segment can be found in the following protein(s): T10374 P2, T10374_P6 and T10374_P9.

Segment cluster T10374_node_33 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3544 below describes the starting and ending position of this segment on each transcript.

Table 3544 - Segment location on transcripts

This segment can be found in the following protein(s): T10374_P2, T10374_P6 and Tl 0374 P9. Segment cluster T10374_node_35 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3545 below describes the starting and ending position of this segment on each transcript.

Table 3545 - Segment location on transcripts

This segment can be found in the following protein(s): T10374_P2, T10374_P6 and T10374_P9.

Segment cluster T10374_node_38 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3546 below describes the starting and ending position of this segment on each transcript.

Table 3546 - Segment location on transcripts

This segment can be found in the following protein(s): T10374JP2, T10374JP6 and Tl 0374 P9.

Segment cluster T10374_node_40 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3547 below describes the starting and ending position of this segment on each transcript. Table 3547 - Segment location on transcripts

This segment can be found in the following protein(s): T10374_P2, T10374_P6 and T10374_P9.

Segment cluster T10374_node_42 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following trarecript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3548 below describes the starting and ending position of this segment on each transcript.

Table 3548 - Segment location on transcripts

This segment can be found in the following protein(s): T10374_P2, T10374_P6 and Tl 0374 P9.

Segment cluster T10374_node_46 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3549 below describes the starting and ending position of this segment on each transcript.

Table 3549 - Segment location on transcripts

This segment can be found in the following protein(s): T10374_P2, T10374_P6 and T10374JP9.

Segment cluster T10374_node_49 according to the present invention is supported by 52 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3550 below describes the starting and ending position of this segment on each transcript.

Table 3550 - Segment location on transcripts

This segment can be found in the following protein(s): T10374_P2, T10374_P6 and Tl 0374 P9.

Segment cluster T10374_node_53 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16, T10374_T24 and T10374_T27. Table 3551 below describes the starting and ending position of this segment on each transcript.

Table 3551 - Segment location on transcripts

This segment can be found in the following protein(s): T10374_P2, T10374_P6 and T10374 P9. Segment cluster T10374_node_61 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16. Table 3552 below describes the starting and ending position of this segment on each transcript.

Table 3552 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374_P2.

Segment cluster T10374_node_64 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the fallowing transcript(s): T10374_T16. Table 3553 below describes the starting and ending position of this segment on each transcript.

Table 3553 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374_P2.

Segment cluster T10374_node_66 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T10374_T16. Table 3554 below describes the starting and ending position of this segment on each transcript.

Table 3554 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T10374_P2.

DESCRIPTION FOR CLUSTER Tl 1832

Cluster Tl 1832 features 8 transcript(s) and 37 segment(s) of interest, the names for which are given in Tables 3555 and 3556, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3557.

Table 3555 - Transcripts of interest

Transcript Name

Tl 1832 T2

Tl 1832 T5

T11832 T6

Tl 1832 T7

Tl 1832 X₉

Tl 1832 TlO

Tl 1832 T12

Tl 1832 TH

Table 3556 - Segments of interest

Segment Name

T11832 node 0

Tl 1832 node 3

T11832 node 5

Tl 1832 node 13

Tl 1832 node 14

T11832 node 17

Tl 1832 node 20

T11832 node 22

Tl 1832 node 27

Tl 1832 node 31

Tl 1832 node 33

Tl 1832 node 34

Tl 1832 node 36

Tl 1832 node 48

Tl 1832 node 57

Table 3557 - Proteins of interest

Cluster Tl 1832 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 88 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 88 and Table 3558. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 3558 - Normal tissue distribution

Table 3559 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 3560.

Table 3560 - Oligonucleotides related to this cluster

As noted above, cluster Tl 1832 features 37 segment(s), which were listed in Table 3556 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T11832_node_0 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T7 and T11832_T14. Table 3561 below describes the starting and ending position of this segment on each transcript.

Table 3561 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Tl 1832_P5 and Tl 1832_P6.

Segment cluster T11832_node_3 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T7 and T11832_T14. Table 3562 below describes the starting and ending position of this segment on each transcript.

Table 3562 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1832_P5 and Tl 1832_P6.

Segment cluster T11832_node_5 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T7 and T11832_T14. Table 3563 below describes the starting and ending position of this segment on each transcript.

Table 3563 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1832JP5 and Tl 1832_P6.

Segment cluster T11832_node_13 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2. Table 3564 below describes the starting and ending position of this segment on each transcript.

Table 3564 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Tl 1832_P2.

Segment cluster T11832_node_14 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2. Table 3565 below describes the starting and ending position of this segment on each transcript.

Table 3565 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P2.

Segment cluster T11832_node_17 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T7 and T11832_T14. Table 3566 below describes the starting and ending position of this segment on each transcript.

Table 3566 - Segment location on. transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 3567.

Table 3567 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): T11832_P2, T11832_P5 and T11832_P6.

Segment cluster T11832_node_20 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T7 and T11832_T14. Table 3568 below describes the starting and ending position of this segment on each transcript.

Table 3568 - Segment location on transcripts

This segment can be found in the following protein(s): T11832_P2, T11832_P5 and Tl 1832 P6.

Segment cluster T11832_node_22 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T7 and T11832_T14. Table 3569 below describes the starting and ending position of this segment on each transcript.

Table 3569 - Segment location on transcripts

This segment can be found in the following protein(s): T11832_P2, T11832_P5 and T11832_P6.

Segment cluster T11832_node_27 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T7 and T11832_T14. Table 3570 below describes the starting and ending position of this segment on each transcript.

Table 3570 - Segment location on transcripts

This segment can be found in the following protein(s): T11832JP2, T11832_P5 and Tl 1832 P6.

Segment cluster T11832_node_31 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T7 and T11832_T14. Table 3571 below describes the starting and ending position of this segment on each transcript.

Table 3571 - Segment location on transcripts

This segment can be found in the following protein(s): T11832_P2, T11832_P5 and Tl 1832 P6. Segment cluster T11832_node_33 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T6 and T11832_T10. Table 3572 below describes the starting and ending position of this segment on each transcript.

Table 3572 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Tl 1832_P4 and Tl 1832_P7.

Segment cluster T11832_node_34 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and

T11832_T14. Table 3573 below describes the starting and ending position of this segment on each transcript.

Table 3573 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P4 and T11832_P7. This segment can also be found in the following protein(s): T11832_P2, T11832_P5 and T11832_P6, since it is in the coding region for the corresponding transcript. Segment cluster T11832_node_36 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and T11832_T14. Table 3574 below describes the starting and ending position of this segment on each transcript.

Table 3574 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P7. This segment can also be found in the following protein(s):

T11832_P2, T11832JM, T11832_P5 and T11832_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_48 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and T11832_T14. Table 3575 below describes the starting and ending position of this segment on each transcript. Table 3575 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P5. This segment can also be found in the following protein(s): T11832_P2, T11832_P4, T11832_P7 and T11832JP6, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_57 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T14. Table 3576 below describes the starting and ending position of this segment on each transcript.

Table 3576 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1832_P6.

Segment cluster T11832_node_59 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T5. Table 3577 below describes the starting and ending position of this segment on each transcript.

Table 3577 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T11832_node_62 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T12. Table 3578 below describes the starting and ending position of this segment on each transcript.

Table 3578 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T11832_node_64 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T9. Table 3579 below describes the starting and ending position of this segment on each transcript.

Table 3579 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T11832_node_65 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T5, T11832_T6, T11832_T7, T11832_T9 and T11832_T10. Table 3580 below describes the starting and ending position of this segment on each transcript.

Table 3580 - Segment location on transcripts

Tl 1832 TlO 1848 2323

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P2, T11832_P4, T11832_P5 and T11832_P7.

Segment cluster T11832_node_66 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T5, T11832_T6, T11832_T7, T11832_T9, T11832_T10 and T11832_T12. Table 3581 below describes the starting and ending position of this segment on each transcript. Table 3581 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P2, T11832_P4, T11832_P5 and T11832_P7.

Segment cluster T11832_node_67 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T5, T11832_T6, T11832_T7, T11832_T9, T11832_T10 and T11832_T12. Table 3582 below describes the starting and ending position of this segment on each transcript.

Table 3582 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P2, T11832_P4, T11832_P5 and T11832_P7.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T11832_node_l according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T7 and T11832_T14. Table 3583 below describes the starting and ending position of this segment on each transcript.

Table 3583 - Segment location on transcripts

This segment can be found in the following protein(s): T11832_P5 and T11832JP6.

Segment cluster T11832_node_7 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T7 and T11832_T14. Table 3584 below describes the starting and ending position of this segment on each transcript.

Table 3584 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1832_P5 and Tl 1832_P6.

Segment cluster T1 1832_node_9 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T7 and T11832_T14. Table 3585 below describes the starting and ending position of this segment on each transcript.

Table 3585 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1832JP5 and T11832_P6.

Segment cluster T11832_node_ll according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T7 and T11832_T14. Table 3586 below describes the starting and ending position of this segment on each transcript.

Table 3586 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1832_P5 and Tl 1832_P6.

Segment cluster T11832_node_15 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T7 and T11832_T14. Table 3587 below describes the starting and ending position of this segment on each transcript.

Table 3587 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P2. This segment can also be found in the following protein(s): Tl 1832_P5 and Tl 1832_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_29 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T7 and T11832_T14. Table 3588 below describes the starting and ending position of this segment on each transcript.

Table 3588 - Segment location on transcripts

This segment can be found in the following protein(s): T11832_P2, T11832_P5 and T11832_P6.

Segment cluster T11832_node_38 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and T11832_T14. Table 3589 below describes the starting and ending position of this segment on each transcript.

Table 3589 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P7. This segment can also be found in the following protein(s): T11832_P2, T11832_P4, T11832_P5 and T11832_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_39 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T7 and T11832_T10. Table 3590 below describes the starting and ending position of this segment on each transcript.

Table 3590 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P7. This segment can also be found in the following protein(s): T11832_P5, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_40 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and

T11832_T14. Table 3591 below describes the starting and ending position of this segment on each transcript.

Table 3591 - Segment location on transcripts

This segment can be found in the following protein(s): T11832_P2, T11832_P4, T11832_P5, T11832_P7 and T11832_P6.

Segment cluster T11832_node_41 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and T11832_T14. Table 3592 below describes the starting and ending position of this segment on each transcript.

Table 3592 - Segment location on transcripts

This segment can be found in the following protein(s): T11832_P2, T11832_P4, T11832_P5, T11832_P7 and T11832_P6.

Segment cluster T11832_node_43 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and T11832_T14. Table 3593 below describes the starting and ending position of this segment on each transcript.

Table 3593 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P5. This segment can also be found in the following protein(s): T11832_P2, T11832_P4, T11832_P7 and T11832JP6, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_50 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and T11832_T14. Table 3594 below describes the starting and ending position of this segment on each transcript.

Table 3594 - Segtnent location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832JP5. This segment can also be found in the following protein(s): T11832_P2, T11832_P4, T11832_P7 and T11832_P6, since it is in the coding region for the corresponding transcript. Segment cluster T11832_node_52 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and T11832_T14. Table 3595 below describes the starting and ending position of this segment on each transcript.

Table 3595 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P5. This segment can also be found in the following protein(s):

T11832_P2, T11832JP4, T11832_P7 and T11832_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_54 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and

T11832_T14. Table 3596 below describes the starting and ending position of this segment on each transcript.

Table 3596 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P5. This segment can also be found in the following protein(s):

T11832_P2, T11832_P4, T11832_P7 and T11832_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_56 according to the present invention can be found in the following transcript(s): T11832_T2, T11832_T6, T11832_T7, T11832_T10 and T11832_T14. Table 3597 below describes the starting and ending position of this segment on each transcript. Table 3597 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P5. This segment can also be found in the following protein(s): T11832_P2, T11832_P4, T11832_P7 and T11832_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T11832_node_60 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11832_T2, T11832_T5, T11832_T6, T11832_T7 and

T11832_T10. Table 3598 below describes the starting and ending position of this segment on each transcript.

Table 3598 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11832_P5. This segment can also be found in the following protein(s): T11832_P2, T11832_P4 and T11832_P7, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER T41334

Cluster T41334 features 7 transcript(s) and 30 segment(s) of interest, the names for which are given in Tables 3599 and 3600, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3601.

Table 3599 - Transcripts of interest

Transcript Name

T41334 TO

T41334 T9

T41334 TlO

T41334 TI l

T41334 T12

T41334 T14

T41334 T16

Table 3600 - Segments of interest

T41334 node 22

T41334 node 25

T41334 node 41

T41334 node 42

T41334 node 49

T41334 node 20

T41334 node 24

T41334 node 29

T41334 node 30

T41334 node 31

T41334 node 32

T41334 node 33

T41334 node 34

T41334 node 35

T41334 node 36

T41334 node 37

T41334 node 38

T41334 node 39

T41334 node 40

T41334 node 43

T41334 node 44

T41334 node 45

T41334 node 46

T41334 node 47

Table 3601 - Proteins of interest

These sequences are variants of the known protein 4OS ribosomal protein SA (SwissProt accession identifier RSP4_HUMAN; known also according to the synonyms P40; 34/67 kDa laminin receptor; Colon carcinoma laminin-binding protein; NEM/1CHD4; Multidrug resistance- associated protein MGrI-Ag), referred to herein as the previously known protein.

The sequence for protein 4OS ribosomal protein SA is given at the end of the application, as "4OS ribosomal protein SA amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3602.

Table 3602 - Amino acid mutations for Known Protein

Protein 4OS ribosomal protein SA localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein biosynthesis; translational regulation; cell adhesion; cell surface receptor linked signal transduction, which are annotation(s) related to Biological Process; structural protein of ribosome; laminin receptor, which are annotation(s) related to Molecular Function; and intracellular; cytosolic small ribosomal (40S) subunit; integrin, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster T41334 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 89 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 89 and Table 3603. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: a mixture of malignant tumors from different tissues, kidney malignant tumors and uterine malignancies. Table 3603 - Normal tissue distribution

Table 3604 - P values and ratios for expression in cancerous tissue

As noted above, cluster T41334 features 30 segment(s), which were listed in Table 3600 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T41334_node_0 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0, T41334_T9, T41334_T10, T41334_T11 and T41334_T16. Table 3605 below describes the starting and ending position of this segment on each transcript.

Table 3605 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T41334_P1 and T41334_P7.

Segment cluster T41334_node_2 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T16. Table 3606 below describes the starting and ending position of this segment on each transcript.

Table 3606 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T41334_node_3 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T16. Table 3607 below describes the starting and ending position of this segment on each transcript.

Table 3607 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T41334_node_14 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T12. Table 3608 below describes the starting and ending position of this segment on each transcript.

Table 3608 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T41334_node_16 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T12. Table 3609 below describes the starting and ending position of this segment on each transcript.

Table 3609 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T41334_node_18 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T12. Table 3610 below describes the starting and ending position of this segment on each transcript.

Table 3610 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T41334_node_22 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T14. Table 3611 below describes the starting and ending position of this segment on each transcript.

Table 3611 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T41334_node_25 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T10, T41334_T11 and T41334_T14. Table 3612 below describes the starting and ending position of this segment on each transcript.

Table 3612 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T41334_node_41 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): T41334_T0. Table 3613 below describes the starting and ending position of this segment on each transcript.

Table 3613 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_42 according to the present invention is supported by 117 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3614 below describes the starting and ending position of this segment on each transcript.

Table 3614 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1. Segment cluster T41334_node_49 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T9. Table 3615 below describes the starting and ending position of this segment on each transcript.

Table 3615 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P7.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T41334_node_20 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0, T41334_T9, T41334_T10 and T41334_T11. Table 3616 below describes the starting and ending position of this segment on each transcript.

Table 3616 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T41334_P1 and T41334_P7.

Segment cluster T41334_node_24 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0, T41334_T9, T41334_T10, T41334_T1 1 and T41334_T14. Table 3617 below describes the starting and ending position of this segment on each transcript.

Table 3617 - Segment location on transcripts

Transcript name Segment Segment starting position ending position

T41334 TO 268 363

T41334 T9 268 363

T41334 TlO 268 363

T41334 TIl 268 363

T41334 T14 126 221

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T41334_P1 and T41334_P7.

Segment cluster T41334_node_29 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3618 below describes the starting and ending position of this segment on each transcript.

Table 3618 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T41334JP1.

Segment cluster T41334_node_30 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3619 below describes the starting and ending position of this segment on each transcript.

Table 3619 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_31 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3620 below describes the starting and ending position of this segment on each transcript.

Table 3620 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_32 according to the present invention can be found in the following transcript(s): T41334_T0. Table 3621 below describes the starting and ending position of this segment on each transcript. Table 3621 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_33 according to the present invention can be found in the following transcript(s): T41334_T0. Table 3622 below describes the starting and ending position of this segment on each transcript.

Table 3622 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_34 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3623 below describes the starting and ending position of this segment on each transcript.

Table 3623 - Segment location on transcripts

This segment can be found in the following protein(s): T41334JP1.

Segment cluster T41334_node_35 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3624 below describes the starting and ending position of this segment on each transcript.

Table 3624 - Segment location on transcripts

This segment can be found in the following protein(s): T41334JP1.

Segment cluster T41334_node_36 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3625 below describes the starting and ending position of this segment on each transcript.

Table 3625 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_37 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3626 below describes the starting and ending position of this segment on each transcript.

Table 3626 - Segment location on transcripts

This segment can be found in the following protein(s): T41334JP1.

Segment cluster T41334_node_38 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3627 below describes the starting and ending position of this segment on each transcript.

Table 3627 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_39 according to the present invention is supported by 115 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3628 below describes the starting and ending position of this segment on each transcript.

Table 3628 - Segment location on transcripts

This segment can be found in the following protein(s): T41334JP1.

Segment cluster T41334__node_40 according to the present invention can be found in the following transcript(s): T41334_T0. Table 3629 below describes the starting and ending position of this segment on each transcript.

Table 3629 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_43 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3630 below describes the starting and ending position of this segment on each transcript. Table 3630 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_44 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3631 below describes the starting and ending position of this segment on each transcript.

Table 3631 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_45 according to the present invention can be found in the following transcript(s): T41334_T0. Table 3632 below describes the starting and ending position of this segment on each transcript.

Table 3632 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_46 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3633 below describes the starting and ending position of this segment on each transcript.

Table 3633 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

Segment cluster T41334_node_47 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T41334_T0. Table 3634 below describes the starting and ending position of this segment on each transcript.

Table 3634 - Segment location on transcripts

This segment can be found in the following protein(s): T41334_P1.

DESCRIPTION FOR CLUSTER T59832

Cluster T59832 features 3 transcript(s) and 19 segment(s) of interest, the names for which are given in Tables 3635 and 3636, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3637.

Table 3635 - Transcripts of interest

Transcript Name

T59832 T18

T59832 T23

T59832 T24

Table 3636 - Segments of interest

Segment Nan*

T59832 node 18

T59832 node 22

T59832 node 23

T59832 node 24

T59832_ node_ 39

T59832 node 19

T59832 node 20

T59832 node 25

T59832 node 26

T59832 node 27

T59832 node 28

T59832 node 30

T59832 node 31

T59832 node 32

T59832 node 34

T59832 node 35

T59832 node 36

T59832 node 37

T59832 node 38 Table 3637 - Proteins of interest

These sequences are variants of the known protein Gamma- interferon inducible lysosomal thiol reductase precursor (SwissProt accession identifier GILT_HUMAN; known also according to the synonyms Gamma- interferon- inducible protein IP- 30), referred to herein as the previously known protein.

Protein Gamma- interferon inducible lysosomal thiol reductase precursor is known or believed to have the following function(s): Cleaves disulfide bonds in proteins by reduction. May facilitate the complet unfolding of proteins destined for lysosomal degradation. May be involved in MHC class II- restricted antigen processing. The sequence for protein Gamma- interferon inducible lysosomal thiol reductase precursor is given at the end of the application, as "Gamma- interferon inducible lysosomal thiol reductase precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3638.

Table 3638 - Amino acid mutations for Known Protein

Protein Gamma- interferon inducible lysosomal thiol reductase precursor localization is believed to be Lysosomal. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: extracellular; lysosome, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from ^ttp^/www.ncbi.nlm.nih.gov/projects/LocusLin^.

Cluster T59832 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 90 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 90 and Table 3639. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, breast malignant tumors, ovarian carcinoma and pancreas carcinoma.

Table 3639 - Normal tissue distribution

Table 3640 - P values and ratios for expression in cancerous tissue

As noted above, cluster T59832 features 19 segment(s), which were listed in Table 3636 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster T59832_node_l 8 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18. Table 3641 below describes the starting and ending position of this segment on each transcript.

Table 3641 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T59832_P15.

Segment cluster T59832_node_22 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T23 and T59832_T24. Table 3642 below describes the starting and ending position of this segment on each transcript.

Table 3642 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T59832_P19.

Segment cluster T59832__node_23 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T23. Table 3643 below describes the starting and ending position of this segment on each transcript.

Table 3643 - Segment location on transcripts

T59832 T23 524 652

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T59832_P19.

Segment cluster T59832_node_24 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T23 and T59832_T24. Table 3644 below describes the starting and ending position of this segment on each transcript.

Table 3644 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T59832_P19.

Segment cluster T59832_node_39 according to the present invention is supported by 195 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3645 below describes the starting and ending position of this segment on each transcript.

Table 3645 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T59832_P15 and T59832_P19. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T59832_node_19 according to the present invention is supported by 300 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18. Table 3646 below describes the starting and ending position of this segment on each transcript.

Table 3646 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T59832_P15.

Segment cluster T59832_node_20 according to the present invention is supported by 318 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18. Table 3647 below describes the starting and ending position of this segment on each transcript.

Table 3647 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15.

Segment cluster T59832_node_25 according to the present invention can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3648 below describes the starting and ending position of this segment on each transcript. Table 3648 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T59832_P19. This segment can also be found in the following protein(s): T59832_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T59832_node_26 according to the present invention is supported by 342 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3649 below describes the starting and ending position of this segment on each transcript.

Table 3649 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15 and T59832_P19.

Segment cluster T59832_node_27 according to the present invention is supported by 314 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3650 below describes the starting and ending position of this segment on each transcript.

Table 3650 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15 and T59832JM9.

Segment cluster T59832_node_28 according to the present invention is supported by 284 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3651 below describes the starting and ending position of this segment on each transcript.

Table 3651 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15 and T59832_P19.

Segment cluster T59832_node_30 according to the present invention can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3652 below describes the starting and ending position of this segment on each transcript. Table 3652 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15 and T59832_P19.

Segment cluster T59832_node_31 according to the present invention can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3653 below describes the starting and ending position of this segment on each transcript.

Table 3653 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15 and T59832_P19.

Segment cluster T59832_node_32 according to the present invention is supported by 287 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3654 below describes the starting and ending position of this segment on each transcript.

Table 3654 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15 and T59832_P19.

Segment cluster T59832_node_34 according to the present invention can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3655 below describes the starting and ending position of this segment on each transcript. Table 3655 - Segment location on transcripts

This segment can be found in the following protein(s): T59832JP15 and T59832_P19. Segment cluster T59832_node_35 according to the present invention can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3656 below describes the starting and ending position of this segment on each transcript.

Table 3656 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15 and T59832_P19.

Segment cluster T59832_node_36 according to the present invention can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3657 below describes the starting and ending position of this segment on each transcript.

Table 3657 - Segment location on transcripts

This segment can be found in the following protein(s): T59832JP15 and T59832_P19.

Segment cluster T59832_node_37 according to the present invention is supported by 300 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3658 below describes the starting and ending position of this segment on each transcript.

Table 3658 - Segment location on transcripts

This segment can be found in the following protein(s): T59832_P15 and T59832_P19.

Segment cluster T59832_node_38 according to the present invention is supported by 247 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T59832_T18, T59832_T23 and T59832_T24. Table 3659 below describes the starting and ending position of this segment on each transcript.

Table 3659 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T59832JP19. This segment can also be found in the following protein(s): T59832_P15, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER T66935

Cluster T66935 features 3 transcript(s) and 15 segment(s) of interest, the names for which are given in Tables 3660 and 3661, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3662.

Table 3660 - Transcripts of interest

Transcript Name

T66935 T4

T66935 T5 T66935 _X9

Table3661 -Segmentsofinterest

SegmentNam« >

T66935 node 0

T66935 node 5

T66935 node 7

T66935 node 10

T66935 node 12

T66935 node 18

T66935 node 19

T66935 node 21

T66935 node 2

T66935 node 4

T66935 node 8

T66935 node 11

T66935 node 13

T66935 node 15

T66935 node 17

Table 3662 - Proteins of interest

Cluster T66935 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 91 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 91 and Table 3663. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues. Table 3663 - Normal tissue distribution

Table 3664 - P values and ratios for expression in cancerous tissue

As noted above, cluster T66935 features 15 segment(s), which were listed in Table 3661 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T66935_node_0 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T9. Table 3665 below describes the starting and ending position of this segment on each transcript.

Table 3665 - Segment location on transcripts

This segment can be found in the following protein(s): T66935_P6.

Segment cluster T66935_node_5 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T9. Table 3666 below describes the starting and ending position of this segment on each transcript.

Table 3666 - Segment location on transcripts

This segment can be found in the following protein(s): T66935_P6. Segment cluster T66935_node_7 according to the present hvention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T5. Table 3667 below describes the starting and ending position of this segment on each transcript.

Table 3667 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T66935JP7.

Segment cluster T66935_node_10 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T4. Table 3668 below describes the starting and ending position of this segment on each transcript.

Table 3668 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T66935_P7.

Segment cluster T66935_node_12 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T4. Table 3669 below describes the starting and ending position of this segment on each transcript.

Table 3669 - Segment location on transcripts

T66935 T4 1451 3026

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T66935_P7.

Segment cluster T66935_node_18 according to the present invention is supported by 79 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T66935_T4 and T66935_T5. Table 3670 below describes the starting and ending position of this segment on each transcript.

Table 3670 - Segment location on transcripts

This segment can be found in the following protein(s): T66935_P7.

Segment cluster T66935_node_19 according to the present invention is supported by 75 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T4 and T66935_T5. Table 3671 below describes the starting and ending position of this segment on each transcript.

Table 3671 - Segment location on transcripts

This segment can be found in the following protein(s): T66935_P7.

Segment cluster T66935_node_21 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T4 and T66935_T5. Table 3672 below describes the starting and ending position of this segment on each transcript. Table 3672 - Segment location on transcripts

This segment can be found in the following protein(s): T66935_P7.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T66935_node_2 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T9. Table 3673 below describes the starting and ending position of this segment on each transcript.

Table 3673 - Segment location on transcripts

This segment can be found in the following protein(s): T66935_P6.

Segment cluster T66935_node_4 according to the present invention is supported by 40 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T66935_T9. Table 3674 below describes the starting and ending position of this segment on each transcript.

Table 3674 - Segment location on transcripts

This segment can be found in the following protein(s): T66935_P6.

Segment cluster T66935__node_8 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T5. Table 3675 below describes the starting and ending position of this segment on each transcript.

Table 3675 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T66935_P7.

Segment cluster T66935_node_l 1 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T4 and T66935_T5. Table 3676 below describes the starting and ending position of this segment on each transcript.

Table 3676 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T66935_P7.

Segment cluster T66935_node_13 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T4 and T66935_T5. Table 3677 below describes the starting and ending position of this segment on each transcript.

Table 3677 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T66935_P7.

Segment cluster T66935_node_15 according to the present invention is supported by 38 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T66935_T4 and T66935_T5. Table 3678 below describes the starting and ending position of this segment on each transcript.

Table 3678 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T66935_P7.

Segment cluster T66935_node_17 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T66935_T4 and T66935_T5. Table 3679 below describes the starting and ending position of this segment on each transcript.

Table 3679 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T66935_P7. DESCRIPTION FOR CLUSTER T78346

Cluster T78346 features 10 transcript(s) and 50 segment(s) of interest, the names for which are given in Tables 3680 and 3681, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3682.

Table 3680 - Transcripts of interest

TranscriptName

T78346 T5

T78346 TIl

T78346 T21

T78346 T22

T78346 T24

T78346 T29

T78346 T30

T78346 T31

T78346 T32

T78346 T35

Table3681 -Segmentsofinterest

SegmentName

T78346 node 0

T78346 node 4

T78346 node 6

T78346 node 7

T78346 node 8

T78346 node 12

T78346 node 19

T78346 node 21

T78346 node 25

T78346 node 29

T78346 node 31

T78346 node 34

T78346 node 35

T78346 node 37

T78346 node 38

T78346 node 40

T78346 node 41

T78346 node 44 T78346 node 46

T78346 node 50

T78346 node 52

T78346 node 53

T78346 node 55

T78346 node 57

T78346 node 58

T78346 node 59

T78346 node 62

T78346 node 66

T78346 node 68

T78346 node 71

T78346 node 73

T78346 node 75

T78346 node 1

T78346 node 2

T78346 node 3

T78346 node 5

T78346 node 9

T78346 node 10

T78346 node 13

T78346 node 15

T78346 node 17

T78346 node 18

T78346 node 22

T78346 node _23

T78346 node 48

T78346 node 60

T78346 node 63

T78346 node 64

T78346 node 72

T78346 node 74

Table 3682 - Proteins of interest

These sequences are variants of the known protein Structural maintenance of chromosomes 4 like 1 protein (SwissProt accession identifier SMC4_HUMAN; known also according to the synonyms Chromosome- associated polypeptide C; hCAP-C; XCAP-C homolog), referred to herein as the previously known protein.

Protein Structural maintenance of chromosomes 4-like 1 protein is known or believed to have the following function(s): Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic- like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The sequence for protein Structural maintenance of chromosomes 4-like 1 protein is given at the end of the application, as "Structural maintenance of chromosomes 4- like 1 protein amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3683. Table 3683 - Amino acid mutations for Known Protein

Protein Structural maintenance of chromosomes 4-like 1 protein localization is believed to be Nuclear and cytoplasmic. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissoc. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: mitotic chromosome segregation; transport; chromosome organization and biogenesis; cell cycle; mitosis; mitotic chromosome condensation, which are annotation(s) related to Biological Process; ATP -binding cassette (ABC) transporter; ATP binding; DNA supercoiling, which are annotations) related to Molecular Function; and nucleus; cytoplasm; membrane, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from ^ttp^/www.ncbi.nlm.nih.gov/projects/LocusLinl^.

Cluster T78346 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 92 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 92 and Table 3684. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, breast malignant tumors, ovarian carcinoma and uterine malignancies.

Table 3684 - Normal tissue distribution

Table 3685 - P values and ratios for expression in cancerous tissue

As noted above, cluster T78346 features 50 segment(s), which were listed m Table 3681 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T78346_node_0 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21 and T78346_T35. Table 3686 below describes the starting and ending position of this segment on each transcript.

Table 3686 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3, T78346_P4, T78346_P11 and T78346_P18.

Segment cluster T78346_node_4 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5 and T78346_T21. Table 3687 below describes the starting and ending position of this segment on each transcript.

Table 3687 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3 and T78346_P11.

Segment cluster T78346_node_6 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5 and T78346_T21. Table 3688 below describes the starting and ending position of this segment on each transcript.

Table 3688 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3 and T78346_P11.

Segment cluster T78346_node_7 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21 and T78346_T35. Table 3689 below describes the starting and ending position of this segment on each transcript.

Table 3689 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3 and T78346_P11. This segment can also be found in the following protein(s): T78346_P4 and T78346_P18, since it is in the coding region for the corresponding transcript. Segment cluster T78346_node_8 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5 and T78346_T21. Table 3690 below describes the starting and ending position of this segment on each transcript.

Table 3690 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3 and T78346_P11.

Segment cluster T78346_node_12 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21 and T78346_T35. Table 3691 below describes the starting and ending position of this segment on each transcript.

Table 3691 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P11. This segment can also be found in the following protein(s): T78346_P3, T78346_P4 and T78346_P18, since it is in the coding region for the corresponding transcript. Segment cluster T78346_node_19 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22 and T78346_T35. Table 13 below describes the starting and ending position of this segment on each transcript.

Table 3692 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P11. This segment can also be found in the following protein(s):

T78346_P3, T78346_P4 and T78346_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_21 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T24. Table 3693 below describes the starting and ending position of this segment on each transcript.

Table 3693 - Segment location on transcripts

This segment can be found in the following ρrotein(s): T78346_P12.

Segment cluster T78346_node_25 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24 and T78346_T35. Table 3694 below describes the starting and ending position of this segment on each transcript.

Table 3694 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12 and T78346JP18.

Segment cluster T78346_node_29 according to the present invention is supported by 75 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24 and T78346_T35. Table 3695 below describes the starting and ending position of this segment on each transcript.

Table 3695 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12 and T78346_P18. Segment cluster T78346_node_31 according to the present invention is supported by 71 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24 and T78346_T35. Table 3696 below describes the starting and ending position of this segment on each transcript.

Table 3696 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346JP11, T78346_P12 and T78346_P18.

Segment cluster T78346_node_34 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24 and T78346_T35. Table 3697 below describes the starting and ending position of this segment on each transcript.

Table 3697 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346JP4, T78346_P11, T78346_P12 and T78346_P18. Segment cluster T78346_node_35 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T35. Table 3698 below describes the starting and ending position of this segment on each transcript.

Table 3698 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P18.

Segment cluster T78346_node_37 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T29. Table 3699 below describes the starting and ending position of this segment on each transcript.

Table 3699 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P14.

Segment cluster T78346_node_38 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24 and T78346_T29. Table 3700 below describes the starting and ending position of this segment on each transcript.

Table 3700 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346_P1 1, T78346_P12 and T78346_P14.

Segment cluster T78346_node_40 according to the present invention is supported by 1 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T78346_T30. Table 3701 below describes the starting and ending position of this segment on each transcript.

Table 3701 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P15.

Segment cluster T78346_node_41 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22,

T78346_T24, T78346_T29 and T78346_T30. Table 3702 below describes the starting and ending position of this segment on each transcript.

Table 3702 - Segment location on transcripts

This segment can be found in the following protein(s): T78346JP3, T78346JP4, T78346_P11, T78346_P12, T78346_P14 and T78346JP15.

Segment cluster T78346_node_44 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29 and T78346_T30. Table 3703 below describes the starting and ending position of this segment on each transcript. Table 3703 - Segment location on transci'ipts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346JP11, T78346_P12, T78346_P14 and T78346_P15.

Segment cluster T78346_node_46 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29 and T78346_T30. Table 3704 below describes the starting and ending position of this segment on each transcript. Table 3704 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12, T78346_P14 and T78346_P15.

Segment cluster T78346_node_50 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29 and T78346_T30. Table 3705 below describes the starting and ending position of this segment on each transcrip t.

Table 3705 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12, T78346__P14 and T78346_P15.

Segment cluster T78346_node_52 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T31. Table 3706 below describes the starting and ending position of this segment on each transcript.

Table 3706 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P16.

Segment cluster T78346_node_53 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30 and T78346_T31. Table 3707 below describes the starting and ending position of this segment on each transcript.

Table 3707 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T78346_P16. This segment can also be found in the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12, T78346_P14 and T78346_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_55 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30 and T78346_T31. Table 3708 below describes the starting and ending position of this segment on each transcript.

Table 3708 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P16. This segment can also be found in the following protein(s): T78346_P3, T78346_P4, T78346JP11, T78346_P12, T78346_P14 and T78346_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_57 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30 and T78346_T31. Table 3709 below describes the starting and ending position of this segment on each transcript.

Table 3709 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P16. This segment can also be found in the following protein(s): T78346_P3, T78346_P4, T78346JP11, T78346_P12, T78346_P14 and T78346_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_58 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T11. Table 3710 below describes the starting and ending position of this segment on each transcript.

Table 3710 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P4.

Segment cluster T78346_node_59 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21_> T78346_T22, T78346_T24, T78346_T29, T78346_T30 and T78346_T31. Table 3711 below describes the starting and ending position of this segment on each transcript.

Table 3711 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P4 and T78346_P16. This segment can also be found in the following protein(s): T78346_P3, T78346_P11, T78346_P12, T78346_P14 and T78346_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_62 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T32. Table 3712 below describes the starting and ending position of this segment on each transcript.

Table 3712 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P16.

Segment cluster T78346_node_66 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3713 below describes the starting and ending position of this segment on each transcript.

Table 3713 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P4. This segment can also be found in the following protein(s): T78346_P3, T78346JP11, T78346_P12, T78346_P14, T78346_P15 and T78346_P16, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_68 according to the present invention is supported by 89 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22,

T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3714 below describes the starting and ending position of this segment on each transcript.

Table 3714 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P4. This segment can also be found in the following protein(s): T78346_P3, T78346JP11, T78346_P12, T78346_P14, T78346_P15 and T78346_P16, since it is in the coding region for the corresponding transcript. Segment cluster T78346_node_71 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3715 below describes the starting and ending position of this segment on each transcript.

Table 3715 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P4. This segment can also be found in the following protein(s):

T78346_P3, T78346JP11, T78346_P12, T78346_P14, T78346_P15 and T78346_P16, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_73 according to the present invention is supported by 92 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22,

T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3716 below describes the starting and ending position of this segment on each transcript.

Table 3716 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12, T78346_P14, T78346 P15 and T78346 P16.

Segment cluster T78346_node_75 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3717 below describes the starting and ending position of this segment on each transcript.

Table 3717 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12, T78346_P14, T78346 P15 and T78346 P16. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T78346_node_l according to the present invention can be found in the following transcript(s): T78346_T5, T78346_T1 1, T78346_T21 and T78346_T35. Table 3718 below describes the starting and ending position of this segment on each transcript.

Table 3718 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3, T78346_P4, T78346_P11 and T78346_P18.

Segment cluster T78346_node_2 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21 and T78346_T35. Table 3719 below describes the starting and ending position of this segment on each transcript.

Table 3719 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T78346_P3, T78346_P4, T78346JP11 and T78346_P18. Segment cluster T78346_node_3 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21 and T78346_T35. Table 3720 below describes the starting and ending position of this segment on each transcript.

Table 3720 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3, T78346_P4, T78346_P11 and T78346_P18.

Segment cluster T78346_node_5 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5 and T78346_T21. Table 3721 below describes the starting and ending position of this segment on each transcript.

Table 3721 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346JP3 and T78346_P11.

Segment cluster T78346_node_9 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21 and T78346_T35. Table 3722 below describes the starting and ending position of this segment on each transcript.

Table 3722 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3 and T78346_P11. This segment can also be found in the following protein(s): T78346_P4 and T78346_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_10 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21 and T78346_T35. Table 3723 below describes the starting and ending position of this segment on each transcript.

Table 3723 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P11. This segment can also be found in the following protein(s): T78346_P3, T78346_P4 and T78346_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_13 according to the present invention can be found in the following transcript(s): T78346_T5, T78346_T11 and T78346_T35. Table 3724 below describes the starting and ending position of this segment on each transcript. Table 3724 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4 and T78346_P18.

Segment cluster T78346_node_15 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T22. Table 3725 below describes the starting and ending position of this segment on each transcript.

Table 3725 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346JP11.

Segment cluster T78346_node_17 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T22 and T78346_T35. Table 3726 below describes the starting and ending position of this segment on each transcript.

Table 3726 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P11. This segment can also be found in the following protein(s): T78346_P3, T78346_P4 and T78346_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_18 according to the present invention can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22 and T78346_T35. Table 48 below describes the starting and ending position of this segment on each transcript.

Table 3727 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P11. This segment can also be found in the following protein(s): T78346_P3, T78346_P4 and T78346_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_22 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24 and T78346_T35. Table 3728 below describes the starting and ending position of this segment on each transcript.

Table 3728 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346JP4, T78346JP11, T78346JP12 and T78346_P18.

Segment cluster T78346_node_23 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346 T24 and T78346_T35. Table 3729 below describes the starting and ending position of this segment on each transcript. Table 3729 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12 and T78346_P18.

Segment cluster T78346_node_48 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29 and T78346_T30. Table 3730 below describes the starting and ending position of this segment on each transcript Table 3730 - Segment location on transcripts

This segment can be found in the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12, T78346_P14 and T78346JP15.

Segment cluster T78346_node_60 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30 and T78346_T31. Table 3731 below describes the starting and ending position of this segment on each transcript.

Table 3731 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346JP4 and T78346_P16. This segment can also be found in the following protein(s): T78346_P3, T78346_P11, T78346_P12, T78346_P14 and T78346_P15, since it is in the coding region for the corresponding transcript. Segment cluster T78346_node_63 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transciipt(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3732 below describes the starting and ending position of this segment on each transcript.

Table 3732 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P4 and T78346JP16. This segment can also be found in the following protein(s): T78346_P3, T78346_P11, T78346_P12, T78346_P14 and T78346_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T78346jnode_64 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3733 below describes the starting and ending position of this segment on each transcript. Table 3733 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P4. This segment can also be found in the following protein(s): T78346_P3, T78346_P11, T78346_P12, T78346_P14, T78346_P15 and T78346_P16, since it is in the coding region for the corresponding transcript.

Segment cluster T78346_node_72 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3734 below describes the starting and ending position of this segment on each transcript.

Table 3734 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3, T78346_P4, T78346_P11, T78346_P12, T78346_P14, T78346 P15 and T78346 P16. Segment cluster T78346_node_74 according to the present invention can be found in the following transcript(s): T78346_T5, T78346_T11, T78346_T21, T78346_T22, T78346_T24, T78346_T29, T78346_T30, T78346_T31 and T78346_T32. Table 3735 below describes the starting and ending position of this segment on each transcript.

Table 3735 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78346_P3, T78346_P4, T78346JP11, T78346_P12, T78346_P14, T78346 P15 and T78346 P16.

DESCRIPTION FOR CLUSTER T78438

Cluster T78438 features 7 transcript(s) and 29 segment(s) of interest, the names for which are given in Tables 3736 and 3737, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3738.

Table 3736 ~ Transcripts of interest

Transcript Name

T78438 T4

T78438 T20

T78438 T24

T78438 T27

Table 3737 - Segments of interest

Table 3738 - Proteins of interest

Cluster T78438 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 93 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 93 and Table 3739. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues, breast malignant tumors and ovarian carcinoma.

Table 3739 - Normal tissue distribution

Table 3740 - P values and ratios for expression in cancerous tissue

As noted above, cluster T78438 features 29 segment(s), which were listed in Table 3737 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T78438_node_0 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3741 below describes the starting and ending position of this segment on each transcript.

Table 3741 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P21, T78438_P10, T78438_P12 and T78438_P14. This segment can also be found in the following protein(s): T78438_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_l according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4. Table 3742 below describes the starting and ending position of this segment on each transcript.

Table 3742 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P21.

Segment cluster T78438_node_3 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3743 below describes the starting and ending position of this segment on each transcript.

Table 3743 - Segment location on transcripts

This segment can be found m a non-coding region of transcript(s) that are related to the following protein(s): T78438JP21, T78438_P10, T78438_P12, T78438_P14 and T78438_P18.

Segment cluster T78438_node_6 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4 and T78438_T27. Table 3744 below describes the stalling and ending position of this segment on each transcript.

Table 3744 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P21 and T78438_P10.

Segment cluster T78438_node_7 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T37. Table 3745 below describes the starting and ending position of this segment on each transcript.

Table 3745 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 3746.

Table 3746 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P10 and T78438_P18. This segment can also be found in the following protein(s): T78438JP21, T78438_P12 and T78438_P14, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_9 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T37. Table 3747 below describes the starting and ending position of this segment on each transcript.

Table 3747 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P18. Segment cluster T78438_node_l l according to the present invention is supported by 148 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3748 below describes the starting and ending position of this segment on each transcript.

Table 3748 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P10. This segment can also be found in the following protein(s):

T78438JP21, T78438_P12 and T78438_P14, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_12 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T20, T78438_T27, T78438_T28 and T78438_T29. Table 3749 below describes the starting and ending position of this segment on each transcript.

Table 3749 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P10. This segment can also be found in the following protein(s): T78438_P14, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_14 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T24 and T78438_T28. Table 3750 below describes the starting and ending position of this segment on each transcript.

Table 3750 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P14. This segment can also be found in the following protein(s): T78438JP12, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_27 according to the present invention is supported by 154 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3751 below describes the starting and ending position of this segment on each transcript.

Table 3751 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P12 and T78438_P14. This segment can also be found in the following protein(s): T78438_P21 and T78438_P10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_32 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T37. Table 3752 below describes the starting and ending position of this segment on each transcript.

Table 3752 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P18.

Segment cluster T78438_node_34 according to the present invention is supported by 181 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3753 below describes the starting and ending position of this segment on each transcript.

Table 3753 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438JP12, T78438_P14 and T78438_P18. This segment can also be found in the following protein(s): T78438_P21 and T78438_P10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_38 according to the present invention is supported by 219 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438 _T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3754 below describes the starting and ending position of this segment on each transcript.

Table 3754 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P21, T78438_P10, T78438_P12, T78438_P14 and T78438_P18.

Segment cluster T78438_node_39 according to the present invention is supported by 229 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27,

T78438_T28, T78438_T29 and T78438_T37. Table 3755 below describes the starting and ending position of this segment on each transcript.

Table 3755 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438JP21, T78438_P10, T78438JP12, T78438_P14 and T78438J^>18.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T78438_node_4 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3756 below describes the starting and ending position of this segment on each transcript. Table 3756 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P21, T78438_P10, T78438_P12, T78438_P14 and T78438_P18. Segment cluster T78438_node_5 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4 and T78438_T27. Table 3757 below describes the starting and ending position of this segment on each transcript.

Table 3757 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P21 and T78438_P10.

Segment cluster T78438_node_8 according to the present invention can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T37. Table 3758 below describes the starting and ending position of this segment on each transcript.

Table 3758 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P10 and T78438_P18. This segment can also be found in the following protein(s): T78438_P21, T78438_P12 aid T78438_P14, since it is in the coding region for the corresponding transcript. Segment cluster T78438_node_13 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3759 below describes the starting and ending position of this segment on each transcript.

Table 3759 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P14. This segment can also be found in the following protein(s):

T78438_P21, T78438_P10 and T78438_P12, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_15 according to the present invention is supported by 97 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3760 below describes the starting and ending position of this segment on each transcript.

Table 3760 - Segment location on transcripts

I T78438JT29 | I 2588 I j 2626 I

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P12 and T78438_P14. This segment can also be found in the following protein(s): T78438_P21 and T78438JP10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_16 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3761 below describes the starting and ending position of this segment on each transcript.

Table 3761 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T78438JP12 and T78438_P14. This segment can also be found in the following protein(s): T78438_P21 and T78438JP10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_17 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3762 below describes the starting and ending position of this segment on each transcript.

Table 3762 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438JP12 and T78438_P14. This segment can also be found in the following protein(s): T78438_P21 and T78438J⁾10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_21 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3763 below describes the starting and ending position of this segment on each transcript.

Table 3763 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P12 and T78438_P14. This segment can also be found in the following protein(s): T78438_P21 and T78438_P10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_22 according to the present invention can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3764 below describes the starting and ending position of this segment on each transcript.

Table 3764 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P12 and T78438_P14. This segment can also be found in the following protein(s): T78438_P21 and T78438_P10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_24 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3765 below describes the starting and ending position of this segment on each transcript.

Table 3765 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P12 and T78438_P14. This segment can also be found in the following protein(s): T78438JP21 and T78438JP10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_28 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28 and T78438_T29. Table 3766 below describes the starting and ending position of this segment on each transcript.

Table 3766 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438JP12 and T78438_P14. This segment can also be found in the following protein(s): T78438_P21 and T78438_P10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_33 according to the present invention is supported by 140 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3767 below describes the starting and ending position of this segment on each transcript.

Table 3767 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438_P12, T78438_P14 and T78438_P18. This segment can also be found in the following protein(s): T78438_P21 and T78438_P10, since it is in the coding region for the corresponding transcript.

Segment cluster T78438_node_35 according to the present invention can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3768 below describes the starting and ending position of this segment on each transcript.

Table 3768 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438JP21, T78438_P10, T78438JP12, T78438JP14 and T78438_P18.

Segment cluster T78438_node_36 according to the present invention is supported by 178 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3769 bebw describes the starting and ending position of this segment on each transcript.

Table 3769 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438JP21, T78438_P10, T78438_P12, T78438_P14 and T78438_P18.

Segment cluster T78438_node_37 according to the present invention can be found in the following transcript(s): T78438_T4, T78438_T20, T78438_T24, T78438_T27, T78438_T28, T78438_T29 and T78438_T37. Table 3770 below describes the starting and ending position of this segment on each transcript.

Table 3770 - Segment location on transcripts

T78438 T37 3192 3197

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T78438JP21, T78438_P10, T78438_P12, T78438_P14 and T78438_P18.

DESCRIPTION FOR CLUSTER T86345

Cluster T86345 features 21 transcript(s) and 45 segment(s) of interest, the names for which are given in Tables 3771 and 3772, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3773.

Table 3771 - Transcripts of interest

Transcript Name .- _; ;•_ ...

T86345 TO

T86345 T2

T86345 T3

T86345 T4

T86345 T5

T86345 T6

T86345 T7

T86345 T8

T86345 TlO

T86345 TIl

T86345 T12

T86345 T13

T86345 T14

T86345 T16

T86345 T17

T86345 T18

T86345_ _T19

T86345 T23

T86345 T24

T86345 T32

T86345 T33

Table 3772 - Segments of interest SegmentName

T86345 node 1

T86345 node 6

T86345 node 12

T86345 node 16

T86345 node 20

T86345 node 25

T86345 node 28

T86345 node 39

T86345 node 41

T86345 node 42

T86345 node 46

T86345 node 51

T86345 node 53

T86345 node 58

T86345 node 65

T86345 node 78

T86345 node 80

T86345 node 0

T86345 node 3

T86345 node 4

T86345 node 8

T86345 node 10

T86345 node 14

T86345 node 18

T86345 node 22

T86345 node 36

T86345 node 47

T86345 node 50

T86345 node 52

T86345 node 54

T86345 node 55

T86345 node 56

T86345 node 60

T86345 node 61

T86345 node 63

T86345 node 64

T86345 node 67

T86345 node 70

T86345 node 71

T86345 node 72

T86345 node 73

T86345 node 75

T86345 node 76 T86345 node 79

T86345 node 82

Table 3773 - Proteins of interest

Cluster T86345 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 94 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 94 and Table 3774. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: adrenal cortical carcinoma, epithelial malignant tumors and gastric carcinoma.

Table 3774 - Normal tissue distribution

Table 3775 - P values and ratios for expression in cancerous tissue

As noted above, cluster T86345 features 45 segment(s), which were listed in Table 3772 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T86345_node_l according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19, T86345_T23 and T86345_T24. Table 3776 below describes the starting and ending position of this segment on each transcript.

Table 3776 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345_P3, T86345_P4, T86345JP5, T86345_P6, T86345_P7, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345JP18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_6 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19, T86345_T23 and T86345_T24. Table 3777 below describes the starting and ending position of this segment on each transcript. Table 3777 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345JP6, T86345_P7, T86345_P10, T86345JP11, T86345_P12, T86345JP13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_12 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345JN2,

T86345JN3, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19,

T86345__T23 and T86345_T24. Table 3778 below describes the starting and ending position of this segment on each transcript.

Table 3778 - Segment location on transcripts

I T86345_T24 | I 729 I I 911 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345JP3, T86345_P4, T86345_P5, T86345_P6, T86345JP7, T86345JP10, T86345_P11, T86345JP12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_l 6 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19,

T86345_T23 and T86345_T24. Table 3779 below describes the starting and ending position of this segment on each transcript.

Table 3779 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345_P10, T86345_P11, T86345JP12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_20 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T11, T86345_T12, T86345_T13,

T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19, T86345_T23 and

T86345_T24. Table 3780 below describes the starting and ending position of this segment on each transcript.

Table 3780 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24. This segment can also be found in the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345JP6, T86345_P7, T86345_P10, T86345_P11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_25 according to the present invention is supported by 30 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19, T86345_T23 and T86345_T24. Table 3781 below describes the starting and ending position of this segment on each transcript. Table 3781 - Segment location on transcripts

This segment can be found in the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P10, T86345_P11, T86345JP12, T86345JP13, T86345_P15, T86345_P16 and T86345_P18.

Segment cluster T86345_node_28 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19, T86345_T23 and T86345_T24. Table 3782 below describes the starting and ending position of this segment on each transcript.

Table 3782 - Segment location on transcripts

This segment can be found in the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345_P9, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18. Segment cluster T86345_node_39 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345JN0, T86345_T11, T86345JN2, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345JN9, T86345_T23 and T86345_T24. Table 3783 below describes the starting and ending position of this segment on each transcript.

Table 3783 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P9, T86345_P10, T86345_P11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345JP18, since it is in the coding region for the corresponding transcript. Segment cluster T86345_node_41 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19, T86345_T23 and T86345_T24. Table 3784 below describes the starting and ending position of this segment on each transcript.

Table 3784 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345JP7. This segment can also be found in the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P9, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript. Segment cluster T86345_node_42 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T24. Table 3785 below describes the starting and ending position of this segment on each transcript.

Table 3785 - Segment location on transcripts

This segment can be found in the following protein(s): T86345_P18.

Segment cluster T86345_node_46 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19 and T86345_T23. Table 3786 below describes the starting and ending position of this segment on each transcript.

Table 3786 - Segment location on transcripts

002438

2155

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P9, T86345JP10, T86345_P12, T86345_P13, T86345_P15 and T86345_P16, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_51 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T2, T86345_T3, T86345_T4 and T86345_T23. Table 3787 below describes the starting and ending position of this segment on each transcript.

Table 3787 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T86345JP4. This segment can also be found in the following protein(s): T86345_P3, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_53 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T2, T86345_T3, T86345_T4 and T86345_T23. Table 3788 below describes the starting and ending position of this segment on each transcript.

Table 3788 - Segment location on transcripts 5 002438

2156

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3 and T86345_P4.

Segment cluster T86345_node_58 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T4 and T86345_T6. Table 3789 below describes the starting and ending position of this segment on each transcript.

Table 3789 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3. This segment can also be found in the following protein(s): T86345_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_65 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T19 and T86345_T23. Table 3790 below describes the starting and ending position of this segment on each transcript.

Table 3790 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3. This segment can also be found in the following protein(s): T86345_P16, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_78 according to the present invention is supported by 7 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T86345_T32 and T86345_T33. Table 3791 below describes the starting and ending position of this segment on each transcript.

Table 3791 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T86345_node_80 according to the present invention is supported by 68 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345JN4, T86345_T16, T86345_T32 and T86345_T33. Table 3792 below describes the starting and ending position of this segment on each transcript.

Table 3792 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345JP4, T86345_P5, T86345_P6, T86345JP7, T86345_P12 and T86345JP13. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, T86345JP10 and T86345_P11, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T86345_node_0 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12,

T86345__T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19,

T86345_T23 and T86345_T24. Table 3793 below describes the starting and ending position of this segment on each transcript.

Table 3793 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345JP5, T86345_P6, T86345_P7, T86345_P9, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15, T86345 P16 and T86345 P18.

Segment cluster T86345_node_3 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19, T86345_T23 and T86345_T24. Table 3794 below describes the starting and ending position of this segment on each transcript.

Table 3794 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345JP10, T86345_P11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_4 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345JTO, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345JN 9,

T86345_T23 and T86345_T24. Table 3795 below describes the starting and ending position of this segment on each transcript.

Table 3795 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_8 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345JN 1, T86345_T12,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19,

T86345_T23 and T86345_T24. Table 3796 below describes the starting and ending position of this segment on each transcript.

Table 3796 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_10 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19,

T86345_T23 and T86345_T24. Table 3797 below describes the starting and ending position of this segment on each transcript.

Table 3797 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345J^>3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345JP15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_14 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4₅

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19,

T86345_T23 and T86345_T24. Table 3798 below describes the starting and ending position of this segment on each transcript.

Table 3798 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345JP9. This segment can also be found in the following protein(s): T86345JP3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345_P10, T86345_P11, T86345_P12, T86345_P13, T86345_P15, T86345_P16 and T86345JP18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_l 8 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0₅ T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19,

T86345_T23 and T86345_T24. Table 3799 below describes the starting and ending position of this segment on each transcript.

Table 3799 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P24 and T86345_P9. This segment can also be found in the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345_P10, T86345JP11, T86345_P12, T86345JP13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_22 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345JN2,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345__T18, T86345_T19,

T86345_T23 and T86345_T24. Table 3800 below describes the starting and ending position of this segment on each transcript.

Table 3800 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T86345_P9. This segment can also be found in the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345JP5, T86345_P6, T86345JP7, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345J^>15, T86345_P16 and T86345JP18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_36 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345 _T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19,

T86345_T23 and T86345_T24. Table 3801 below describes the starting and ending position of this segment on each transcript.

Table 3801 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P9, T86345_P10, T86345JP11, T86345JP12, T86345_P13, T86345_P15, T86345_P16 and T86345_P18, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_47 according to the present invention can be found in the following transcript(s): T86345_T3. Table 3802 below describes the starting and ending position of this segment on each transcript.

Table 3802 - Segment location on transcripts

This segment can be found in the following protein(s): T86345_P4. Segment cluster T86345_node_50 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19 and T86345_T23. Table 3803 below describes the starting and ending position of this segment on each transcript.

Table 3803 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P9, T86345_P10, T86345_P12, T86345_P13, T86345_P15 and T86345_P16, since it is in the coding region for the corresponding transcript. Segment cluster T86345_node_52 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T2, T86345_T3, T86345_T4, T86345_T5 and T86345_T23. Table 3804 below describes the starting and ending position of this segment on each transcript.

Table 3804 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3 and T86345_P4. This segment can also be found in the following protein(s): T86345_P5, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_54 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4,

T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12,

T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19 and

T86345_T23. Table 3805 below describes the starting and ending position of this segment on each transcript.

Table 3805 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5 and T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P6, T86345_P9, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15 and T86345_P16, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_55 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T23. Table 3806 below describes the starting and ending position of this segment on each transcript.

Table 3806 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3. Segment cluster T86345_node_56 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19 and T86345_T23. Table 3807 below describes the starting and ending position of this segment on each transcript.

Table 3807 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345JP4, T86345JP5 and T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P6, T86345JP9, T86345_P10, T86345_P11, T86345_P12, T86345_P13, T86345_P15 and T86345_P16, since it is in the coding region for the corresponding transcript. Segment cluster T86345_node_60 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19 and T86345_T23. Table 3808 below describes the starting and ending position of this segment on each transcript.

Table 3808 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of tanscript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5 and T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345JP6, T86345_P9, T86345_P10, T86345_P11, T86345_P12, T86345_P13, T86345_P15 and T86345_P16, since it is in the coding region for the corresponding transcript. Segment cluster T86345_node_61 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345JN8, T86345_T19 and T86345_T23. Table 3809 below describes the starting and ending position of this segment on each transcript.

Table 3809 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6 and T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, TS6345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15 and T86345_P16, since it is in the coding region for the corresponding transcript. Segment cluster T86345_node_63 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19 and T86345_T23. Table 3810 below describes the starting and ending position of this segment on each transcript.

Table 3810 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345JP4, T86345_P5, T86345_P6 and T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, T86345_P10, T86345JP11, T86345_P12, T86345_P13, T86345_P15 and T86345_P16, since it is in the coding region for the corresponding transcript. Segment cluster T86345_node_64 according to the present invention is supported by 63 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17, T86345_T18, T86345_T19 and T86345_T23. Table 3811 below describes the starting and ending position of this segment on each transcript.

Table 3811 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6 and T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, T86345_P10, T86345_P11, T86345_P12, T86345_P13, T86345_P15 and T86345_P16, since it is in the coding region for the corresponding transcript. Segment cluster T86345_node_67 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17 and T86345_T18. Table 3812 below describes the starting and ending position of this segment on each transcript.

Table 3812 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6 and T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, T86345JP11, T86345_P12, T86345_P13 and T86345_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_70 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T16, T86345_T17 and T86345_T18. Table 3813 below describes the starting and ending position of this segment on each transcript.

Table 3813 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6 and T86345_P7. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, T86345_P10, T86345JP11, T86345_P12 and T86345_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_71 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345JN 1, T86345_T12, T86345_T13, T86345_T16, T86345_T17 and T86345_T18. Table 3814 below describes the starting and ending position of this segment on each transcript.

Table 3814 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6 and T86345_P7. This segment can also be found in the following protein(s): T86345JP24, T86345_P9, T86345_P10, T86345_P11, T86345_P12 and T86345_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_72 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T13, T86345_T16 and T86345JH8. Table 3815 below describes the starting and ending position of this segment on each transcript.

Table 3815 - Segment location on transcripts

This segment can be found in the following protein(s): T86345_P12. Segment cluster T86345_node_73 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17 and T86345_T18. Table 3816 below describes the starting and ending position of this segment on each transcript.

Table 3816 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of tanscript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345JP4, T86345J^>5, T86345_P6, T86345_P7 and T86345_P12. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, T86345JP10, T86345_P11, T86345_P13 and T86345JP15, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_75 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T0, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345_T12, T86345_T13, T86345_T14, T86345_T16, T86345_T17 and T86345_T18. Table 3817 below describes the starting and ending position of this segment on each transcript.

Table 3817 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P7, T86345_P12 and T86345_P13. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, T86345_P10, T86345_P11 and T86345_P15, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_76 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T18. Table 3818 below describes the starting and ending position of this segment on each transcript.

Table 3818 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P12.

Segment cluster T86345_node_79 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345JTO, T86345_T2, T86345_T3, T86345_T4, T86345_T5, T86345_T6, T86345_T7, T86345_T8, T86345_T10, T86345_T11, T86345JN2, T86345_T13, T86345_T14, T86345_T16, T86345_T32 and T86345_T33. Table 3819 below describes the starting and ending position of this segment on each transcript.

Table 3819 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T86345_P3, T86345_P4, T86345_P5, T86345_P6, T86345_P7,

T86345_P12 and T86345_P13. This segment can also be found in the following protein(s): T86345_P24, T86345_P9, T86345_P10 and T86345_P11, since it is in the coding region for the corresponding transcript.

Segment cluster T86345_node_82 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T86345_T17. Table 3820 below describes the starting and ending position of this segment on each transcript.

Table 3820 - Segment location on transcripts

This segment can be found in the following protein(s): T86345_P15.

DESCRIPTION FOR CLUSTER T93947

Cluster T93947 features 3 transcript(s) and 22 segment(s) of interest, the names for which are given in Tables 3821 and 3822, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3823.

Table 3821 - Transcripts of interest

Transcript Name

T93947 T21

T93947 T23

T93947 T24

Table 3822 - Segments of interest

Segment Name

T93947 node 15

T93947 node 17

T93947 node 29

T93947 node 31

T93947 node 37

T93947 node 44

T93947 node 46 T93947 node 57

T93947 node 0

T93947 node 1

T93947 node 11

T93947 node 12

T93947 node 19

T93947 node 21

T93947 node 25

T93947 node 27

T93947_ node 33

T93947 node 36

T93947 node 38

T93947 node 41

T93947 node 53

T93947 node 55

Table 3823 - Proteins of interest

Cluster T93947 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 95 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 95 and Table 3824. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 3824 - Normal tissue distribution

Table 3825 - P values and ratios for expression in cancerous tissue

As noted above, cluster T93947 features 22 segment(s), which were listed in Table 3822 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T93947_node_15 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3826 below describes the starting and ending position of this segment on each transcript.

Table 3826 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P 11.

Segment cluster T93947_node_17 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3827 below describes the starting and ending position of this segment on each transcript.

Table 3827 ^' - Segment location on transcripts

This segment can be found in the following protein(s): T93947JP11.

Segment cluster T93947_node_29 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3828 below describes the starting and ending position of this segment on each transcript.

Table 3828 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_31 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3829 below describes the starting and ending position of this segment on each transcript.

Table 3829 - Segment location on transcripts

This segment can be found in the following protein(s): T93947JP11.

Segment cluster T93947_node_37 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3830 below describes the starting and ending position of this segment on each transcript.

Table 3830 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_44 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3831 below describes the starting and ending position of this segment on each transcript.

Table 3831 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_46 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3832 below describes the starting and ending position of this segment on each transcript.

Table 3832 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_57 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21, T93947_T23 and T93947_T24. Table 3833 below describes the starting and ending position of this segment on each transcript.

Table 3833 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T93947_node_0 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3834 below describes the starting and ending position of this segment on each transcript. Table 3834 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T93947_P11.

Segment cluster T93947_node_l according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3835 below describes the starting and ending position of this segment on each transcript.

Table 3835 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T93947_P11.

Segment cluster T93947_node_l 1 according to the present invention can be found in the following transcript(s): T93947_T21. Table 3836 below describes the starting and ending position of this segment on each transcript. Table 3836 - Segment location on transcripts

This segment can be fcund in the following protein(s): T93947_P11.

Segment cluster T93947_node_12 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): T93947_T21. Table 3837 below describes the starting and ending position of this segment on each transcript.

Table 3837 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_19 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3838 below describes the starting and ending position of this segment on each transcript.

Table 3838 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_21 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3839 below describes the starting and ending position of this segment on each transcript. Table 3839 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_25 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3840 below describes the starting and ending position of this segment on each transcript.

Table 3840 - Segment location on transcripts

This segment can be found in the following protein(s): T93947JP11.

Segment cluster T93947_node_27 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3841 below describes the starting and ending position of this segment on each transcript.

Table 3841 - Segment location on transcripts

This segment can be found in the following protein(s): T93947JP11.

Segment cluster T93947_node_33 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3842 below describes the starting and ending position of this segment on each transcript. Table 3842 - Segment location on transcripts

This segment can be found in the following protein(s): T93947JP11.

Segment cluster T93947_node_36 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3843 below describes the starting and ending position of this segment on each transcript.

Table 3843 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_38 according to the present invention can be found in the following transcript(s): T93947_T21. Table 3844 below describes the starting and ending position of this segment on each transcript.

Table 3844 - Segment location on transcripts

This segment can be found in the following protein(s): T93947JP11.

Segment cluster T93947_node_41 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T21. Table 3845 below describes the starting and ending position of this segment on each transcript. Table 3845 - Segment location on transcripts

This segment can be found in the following protein(s): T93947_P11.

Segment cluster T93947_node_53 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T23. Table 3846 below describes the starting and ending position of this segment on each transcript.

Table 3846 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T93947_node_55 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T93947_T24. Table 3847 below describes the starting and ending position of this segment on each transcript.

Table 3847 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER W25389 Cluster W25389 features 2 transcript(s) and 6 segment(s) of interest, the names for which are given in Tables 3848 and 3849, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3850.

Table 3848 - Transcripts of interest

Transcript Name

W25389 T6

W25389 T7

Table 3849 - Segments of interest

Segment Name

W25389 node 9

W25389 node 10

W25389 node 12

W25389 node 14

W25389 node 17

W25389 node 19

Table 3850 - Proteins of interest

Cluster W25389 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 96 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 96 and Table 3851. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors and a mixture of malignant tumors from different tissues. Table 3851 - Normal tissue distribution

Table 3852 - P values and ratios for expression in cancerous tissue

As noted above, cluster W25389 features 6 segment(s), which were listed in Table 3849 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster W25389_node_9 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W25389_T6 and W25389_T7. Table 3853 below describes the starting and ending position of this segment on each transcript.

Table 3853 - Segment location on transcripts

This segment can be found in the following protein(s): W25389JP4.

Segment cluster W25389_node_10 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W25389_T6 and W25389_T7. Table 3854 below describes the starting and ending position of this segment on each transcript.

Table 3854 - Segment location on transcripts

This segment can be found in the following protein(s): W25389JP4.

Segment cluster W25389_node_12 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W25389_T6 and W25389_T7. Table 3855 below describes the starting and ending position of this segment on each transcript.

Table 3855 - Segment location on transcripts

This segment can be found in the following protein(s): W25389_P4.

Segment cluster W25389_node_14 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W25389_T6 and W25389_T7. Table 3856 below describes the starting and ending position of this segment on each transcript.

Table 3856 - Segment location on transcripts

This segment can be found in the following protein(s): W25389_P4.

Segment cluster W25389_node_17 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W25389_T6 and W25389_T7. Table 3857 below describes the starting and ending position of this segment on each transcript.

Table 3857 - Segment locatioyi on transcripts

This segment can be found in the following protein(s): W25389_P4. Segment cluster W25389_node_19 according to the present invention is supported by 75 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): W25389_T6 and W25389_T7. Table 3858 below describes the starting and ending position of this segment on each transcript.

Table 3858 - Segment location on transcripts

This segment can be found in the following protein(s): W25389_P4.

DESCRIPTION FOR CLUSTER Zl 9129

Cluster Zl 9129 features 10 transcript(s) and 71 segment(s) of interest, the names for which are given in Tables 3859 and 3860, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3861.

Table 3859 - Transcripts of interest

Transcript Name

Z19129 T4

Z19129 T7

Z19129 T19

Z19129 T22

Z19129 T26

Z19129 T28

Z19129 T29

Z19129 T30

Z19129 T31

Z19129 T33

Table 3860 - Segments of interest

Segment Name

Z19129 node 8 Z19129 node 39

Z19129 node 43

Z19129 node 50

Z19129 node 51

Z19129 node 53

Z19129 node 54

Z19129 node 56

Z19129 node 61

Z19129 node 62

Z19129_.node 67

Z19129 node 86

Z19129 node 87

Z19129 node 88

Z19129 node 98

Z19129 node 102

Z19129 node 106

Z19129 node 108

Z19129 node 109

Z19129 node 110

Z19129 node 118

Z19129 node 119

Z19129 node 120

Z19129 node 121

Z19129 node 122

Z19129 node 124

Z19129 node 125

Table 3861 - Proteins of interest

These sequences are variants of the known protein CH-TOG protein (SwissProt accession identifier CTOG_HUMAN; known also according to the synonyms Colonic and hepatic tumor over-expressed protein), referred to herein as the previously known protein. The sequence for protein CH-TOG protein is given at the end of the application, as 'CH- TOG protein amino acid sequence". Known polymorphisms for this sequence are as shown in Table 3862.

Table 3862 - Amino acid mutations for Known Protein

Cluster Zl 9129 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 97 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 97 and Table 3863. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: colorectal cancer, a mixture of malignant tumors from different tissues and myosarcoma.

Table 3863 - Normal tissue distribution

Table 3864 - P values and ratios for expression in cancerous tissue

As noted above, cluster Zl 9129 features 71 segment(s), which were listed in Table 3860 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z19129_node_8 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3865 below describes the starting and ending position of this segment on each transcript.

Table 3865 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129JP3, Z19129_P25 and Z19129 P27.

Segment cluster Z19129_node_10 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3866 below describes the starting and ending position of this segment on each transcript.

Table 3866 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129JP25 and Z19129_P27.

Segment cluster Z19129_node_12 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3867 below describes the starting and ending position of this segment on each transcript.

Table 3867 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129 P27.

Segment cluster Z19129_node_14 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129JB3. Table 3868 below describes the starting and ending position of this segment on each transcript.

Table 3868 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129 P27. Segment cluster Z19129_node_25 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3869 below describes the starting and ending position of this segment on each transcript.

Table 3869 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129_P27.

Segment cluster Z19129_node_27 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3870 below describes the starting and ending position of this segment on each transcript.

Table 3870 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129 P27.

Segment cluster Z19129_node_29 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129 J4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3871 below describes the starting and ending position of this segment on each transcript. Table 3871 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129_P27.

Segment cluster Z19129_node_37 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3872 below describes the starting and ending position of this segment on each transcript.

Table 3872 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129 P27.

Segment cluster Z19129_node_42 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T7. Table 3873 below describes the starting and ending position of this segment on each transcript.

Table 3873 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P6.

Segment cluster Z19129_node_45 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3874 below describes the starting and ending position of this segment on each transcript. Table 3874 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6, Z19129 P25 and Z19129 P27.

Segment cluster Z19129_node_57 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129__T33. Table 3875 below describes the starting and ending position of this segment on each transcript.

Table 3875 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129JP27. Segment cluster Z19129_node_59 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3876 below describes the starting and ending position of this segment on each transcript.

Table 3876 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129 P6 and Z19129_P25.

Segment cluster Z19129_node_65 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3877 below describes the starting and ending position of this segment on each transcript.

Table 3877 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6 and Z19129 P25.

Segment cluster Z19129_node 69 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3878 below describes the starting and ending position of this segment on each transcript. Table 3878 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129JP6 and Z19129JP25.

Segment cluster Z19129_node_71 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3879 below describes the starting and ending position of this segment on each transcript.

Table 3879 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6 and Z19129 P25.

Segment cluster Z19129_node_72 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4. Table 3880 below describes the starting and ending position of this segment on each transcript.

Table 3880 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3.

Segment cluster Z19129_node_73 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3881 below describes the starting and ending position of this segment on each transcript.

Table 3881 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129 P6 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_75 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3882 below describes the starting and ending position of this segment on each transcript.

Table 3882 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_77 according to the present invention is supported by 1 libraries. The number of libraries was deteπnined as previous Iy described. This segment can be found in the following transcript(s): Z19129_T19. Table 3883 below describes the starting and ending position of this segment on each transcript.

Table 3883 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : Z 19129_P 16.

Segment cluster Z19129_node_79 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T30 and

Z19129 T31. Table 3884 below describes the starting and ending position of this segment on each transcript.

Table 3884 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_81 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T30 and Z19129_T31. Table 3885 below describes the starting and ending position of this segment on each transcript.

Table 3885 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129JP3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_85 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T22. Table 3886 below describes the starting and ending position of this segment on each transcript.

Table 3886 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P18.

Segment cluster Z19129_node_90 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T30 and Z19129_T31. Table 3887 below describes the starting and ending position of this segment on each transcript.

Table 3887 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found h the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_93 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T30 and Z19129_T31. Table 3888 below describes the starting and ending position of this segment on each transcript.

Table 3888 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_94 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T30 and Z19129_T31. Table 3889 below describes the starting and ending position of this segment on each transcript.

Table 3889 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P25.

Segment cluster Z19129_node_96 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19 and Z19129_T22. Table 3890 below describes the starting and ending position of this segment on each transcript. Table 3890 - Segment location on transcripts

Z19129 T22 759 946

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16 and Z19129_P18, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_100 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T26. Table 3891 below describes the starting and ending position of this segment on each transcript.

Table 3891 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P22.

Segment cluster Z19129_node_101 according to the present invention is supported by 95 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22 and Z19129_T26. Table 3892 below describes the starting and ending position of this segment on each transcript.

Table 3892 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129JP6, Z19129_P16, Z19129_P18 and Z19129_P22, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129jiode_104 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22 and Z19129_T26. Table 3893 below describes the starting and ending position of this segment on each transcript.

Table 3893 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129JP22, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_115 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T28 and Z19l29_T29. Table 3894 below describes the starting and ending position of this segment on each transcript.

Table 3894 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P24.

Segment cluster Z19129_node_l 16 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129_T29. Table 3895 below describes the starting and ending position of this segment on each transcript.

Table 3895 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129JP3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18, Z19129_P22 and Z19129_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_117 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T29. Table 3896 below describes the starting and ending position of this segment on each transcript. Table 3896 - Segment location on transcripts

The previously - described transcripts for ttese segment(s) do not code for protein.

Segment cluster Z19129_node_123 according to the present invention is supported by 175 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129_T29. Table 3897 below describes the starting and ending position of this segment on each transcript.

Table 3897 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18, Z19129_P22 and Z19129_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_126 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22,

Z19129_T26, Z19129_T28 and Z19129_T29. Table 3898 below describes the starting and ending position of this segment on each transcript. Table 3898 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3, Z19129_P6, Z19129_P16, Z19129_P18, Z19129_P22 and Z19129 P24.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z19129_node_0 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3899 below describes the starting and ending position of this segment on each transcript.

Table 3899 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3, Z19129_P25 and Z19129_P27. Segment cluster Z19129_node_4 according to the present invention can be found in the following transcript(s): Z19129_T4, Z19129JT30, Z19129_T31 and Z19129_T33. Table 3900 below describes the starting and ending position of this segment on each transcript.

Table 3900 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3, Z19129JP25 and Z19129_P27.

Segment cluster Z19129_node_5 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3901 below describes the starting and ending position of this segment on each transcript.

Table 3901 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129JP3, Z19129_P25 and Z19129 P27.

Segment cluster Z19129_node_16 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, 219129_T30, Z19129_T31 and Z19129_T33. Table 3902 below describes the starting and ending position of this segment on each transcript. Table 3902 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129_P27.

Segment cluster Z19129_node_18 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3903 below describes the starting and ending position of this segment on each transcript.

Table 3903 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129 P27.

Segment cluster Z19129_node_19 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3904 below describes the starting and ending position of this segment on each transcript.

Table 3904 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129JP3, Z19129JP25 and Z19129_P27.

Segment cluster Z19129_node_21 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3905 below describes the starting and ending position of this segment on each transcript.

Table 3905 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129J^>3, Z19129_P25 and Z19129 P27.

Segment cluster Z19129_node_23 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3906 below describes the starting and ending position of this segment on each transcript.

Table 3906 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129_P27.

Segment cluster Z19129_node_31 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3907 below describes the starting and ending position of this segment on each transcript.

Table 3907 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and

Z19129 P27.

Segment cluster Z19129_node_33 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3908 below describes the starting and ending position of this segment on each transcript.

Table 3908 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129 P27. Segment cluster Z19129_node_35 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3909 below describes the starting and ending position of this segment on each transcript.

Table 3909 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129_P27.

Segment cluster Z19129_node_39 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3910 below describes the starting and ending position of this segment on each transcript.

Table 3910 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129 P27.

Segment cluster Z19129_node_43 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3911 below describes the starting and ending position of this segment on each transcript.

Table 3911 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z19129_P6. This segment can also be found in the following protein(s): Z19129_P3, Z19129_P25 and Z19129_P27, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_50 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3912 below describes the starting and ending position of this segment on each transcript.

Table 3912 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6, Z19129 P25 and Z19129 P27. Segment cluster Z19129_node_51 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3913 below describes the starting and ending position of this segment on each transcript.

Table 3913 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6, Z19129_P25 and Z19129_P27.

Segment cluster Z19129_node_53 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3914 below describes the starting and ending position of this segment on each transcript.

Table 3914 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6, Z19129 P25 and Z19129 P27. Segment cluster Z19129_node_54 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30, Z19129_T31 and Z19129_T33. Table 3915 below describes the starting and ending position of this segment on each transcript.

Table 3915 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129JP3, Z19129_P6, Z19129 P25 and Z19129 P27.

Segment cluster Z19129_node_56 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30, Z19129_T31 and

Z19129_T33. Table 3916 below describes the starting and ending position of this segment on each transcript.

Table 3916 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129JP3, Z19129_P6, Z19129 P25 and Z19129 P27. Segment cluster Z19129_node_61 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3917 below describes the starting and ending position of this segment on each transcript.

Table 3917 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6 and Z19129_P25.

Segment cluster Z19129_node_62 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3918 below describes the starting and ending position of this segment on each transcript.

Table 3918 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6 and Z19129 P25.

Segment cluster Z19129_node_67 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T30 and Z19129_T31. Table 3919 below describes the starting and ending position of this segment on each transcript. Table 3919 - Segment location on transcripts

This segment can be found in the following protein(s): Z19129_P3, Z19129_P6 and Z19129_P25.

Segment cluster Z19129_node_86 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T30 and Z19129_T31. Table 3920 below describes the starting and ending position of this segment on each transcript.

Table 3920 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s):

Z19129_P6, Z19129_P16, Z19129_P18 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_87 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T30 and Z19129_T31. Table 3921 below describes the starting and ending position of this segment on each transcript.

Table 3921 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_88 according to the present invention can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T30 and Z19129JT31. Table 3922 below describes the starting and ending position of this segment on each transcript.

Table 3922 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129JP3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129_P25, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_98 according to the present invention is supported by 65 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19 and Z19129_T22. Table 3923 bebw describes the starting and ending position of this segment on each transcript.

Table 3923 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129JP6, Z19129_P16 and Z19129_P18, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_102 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22 and Z19129_T26. Table 3924 below describes the starting and ending position of this segment on each transcript.

Table 3924 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129_P22, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_106 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22 and Z19129_T26. Table 3925 below describes the starting and ending position of this segment on each transcript.

Table 3925 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129JP22, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_108 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22 and Z19129_T26. Table 3926 below describes the starting and ending position of this segment on each transcript.

Table 3926 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129JP3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129JP22, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_109 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22 and Z19129_T26. Table 3927 below describes the starting and ending position of this segment on each transcript.

Table 3927 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129_P22, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_110 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22 and Z19129_T26. Table 3928 below describes the starting and ending position of this segment on each transcript.

Table 3928 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18 and Z19129_P22, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_l 18 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129_T29. Table 3929 below describes the starting and ending position of this segment on each transcript.

Table 3929 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129 P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18, Z19129_P22 and Z19129_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_l 19 according to the present invention can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129_T29. Table 3930 below describes the starting and ending position of this segment on each transcript.

Table 3930 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18, Z19129_P22 and Z19129_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Zl 9129_node_120 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129JG9. Table 3931 below describes the starting and ending position of this segment on each transcript.

Table 3931 ~ Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129 P3. This segment can also be found in the following protein(s):

Z19129_P6, Z19129_P16, Z19129_P18, Z19129JP22 and Z19129_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_121 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129_T29. Table 3932 below describes the starting and ending position of this segment on each transcript.

Table 3932 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18, Z19129_P22 and Z19129_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129_node_122 according to the present invention is supported by 139 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129_T29. Table 3933 below describes the starting and ending position of this segment on each transcript.

Table 3933 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129_P3. This segment can also be found in the following protein(s): Z19129_P6, Z19129_P16, Z19129_P18, Z19129_P22 and Z19129_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z19129jnode_124 according to the present invention is supported by 161 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129_T29. Table 3934 below describes the starting and ending position of this segment on each transcript.

Table 3934 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z19129_P3, Z19129_P6, Z19129JP16, Z19129_P18, Z19129_P22 and Z19129 P24.

Segment cluster Z19129_node_125 according to the present invention is supported by 132 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19129_T4, Z19129_T7, Z19129_T19, Z19129_T22, Z19129_T26, Z19129_T28 and Z19129_T29. Table 3935 below describes the starting and ending position of this segment on each transcript.

Table 3935 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19129JP3, Z19129_P6, Z19129_P16, Z19129_P18, Z19129_P22 and Z19129 P24. DESCRIPTION FOR CLUSTER Z 19214

Cluster Z 19214 features 19 transcript(s) and 53 segment(s) of interest, the names for which are given in Tables 3936 and 3937, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3938.

Table 3936 - Transcripts of interest

TranscriptName

Z19214 T35

Z19214 T43

Z19214 T44

Z19214 T46

Z19214 T49

Z19214 T50

Z19214 T51

Z19214 T52

Z19214 T53

Z19214 T54

Z19214 T55

Z19214 T56

Z19214 T57

Z19214 T58

Z19214 T59

Z19214 T60

Z19214 T63

Z19214 T66

Z19214 T68

Table 3937 - Segments ofinter-est

SegmentName

Z19214 node 1

Z19214 node 4

Z19214 node 6

Z19214 node 8

Z19214 node 13

Z19214 node 15

Z19214 node 17 Z19214 node 19

Z19214 node 21

Z19214 node 23

Z19214 node 25

Z19214 node 28

Z19214 node 34

Z19214 node 55

Z19214 node 59

Z19214 node 61

Z19214 node _66

Z19214 node 70

Z19214 node 75

Z19214 node 77

Z19214 node 84

Z19214 node 86

Z19214 node 92

Z19214 node 93

Z19214 node 0

Z19214 node 2

Z19214 node 10

Z19214 node 14

Z19214 node 20

Z19214 node 24

Z19214 node 30

Z19214 node 32

Z19214 node 37

Z19214 node 39

Z19214 node 41

Z19214 node 43

Z19214 node 45

Z19214 node 49

Z19214 node 50

Z19214 node 52

Z19214 node 56

Z19214 node 57

Z19214 node 58

Z19214 node 60

Z19214 node 63

Z19214 node 68

Z19214 node 72

Z19214 node 79

Z19214 node 80

Z19214 node 82

Z19214 node 88 Zl 9214 node 89

Zl 9214 node 90

Table 3938 - Proteins of interest

These sequences are variants of the known protein Aspartyl/asparaginyl beta- hydroxylase (SwissProt accession identifier ASPH_HUMAN; known also according to the synonyms EC 1.14.11.16; Aspartate beta- hydroxylase; ASP beta- hydroxylase; Peptide-aspartate beta- dioxygenase), referred to herein as the previously known protein.

Protein Aspartyl/asparaginyl beta-hydroxylase is known or believed to have the following function(s): Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor- like (EGF) domains of a number of proteins. The sequence for protein Aspartyl/asparaginyl beta-hydroxylase is given at the end of the application, as "Aspartyl/asparaginyl beta- hydroxylase amino acid sequence". Protein Aspartyl/asparaginyl beta-hydroxylase localization is believed to be Type II membrane protein. Endoplasmic reticulum.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: muscle contraction, which are annotation(s) related to Biological Process; peptide-aspartate beta-dioxygenase; electron transporter; calcium binding; structural protein of muscle, which are annotation(s) related to Molecular Function; and endoplasmic reticulum membrane, which are annotation(s) related to Cellular Component.

The GO assignment relies on infoπnation from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster Z 19214 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 98 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 98 and Table 3939. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: colorectal cancer, kidney malignant tumors, prostate cancer and uterine malignancies.

Table 3939 - Normal tissue distribution

Table 3940 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z19214 features 53 segment(s), which were listed in Table 3937 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z19214_node_l according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43, Z19214_T44, Z19214_T46, Z19214_T53, Z19214_T55, Z19214_T56, Z19214_T57, Z19214_T60 and Z19214_T63. Table 3941 below describes the starting and ending position of this segment on each transcript.

Table 3941 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36, Z19214_P37, Z19214_P39, Z19214JP43, Z19214JP45, Z19214JP46, Z19214_P47, Z19214JP49 and Z19214 P51.

Segment cluster Z19214_node_4 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T49, Z19214_T50, Z19214 J51, Z19214_T52, Z19214_T54 and Z19214_T68. Table 3942 below describes the starting and ending position of this segment on each transcript. Table 3942 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P42 and Z19214_P44.

Segment cluster Z19214__node_6 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T68. Table 3943 below describes the starting and ending position of this segment on each transcript.

Table 3943 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z19214_node_8 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43, Z19214_T44, Z19214_T46, Z19214_T49, Z19214_T50, Z19214_T51, Z19214_T52, Z19214_T53, Z19214_T54, Z19214_T55, Z19214_T56, Z19214_T57, Z19214_T60 and Z19214_T63. Table 3944 below describes the starting and ending position of this segment on each transcript.

Table 3944 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36, Z19214_P37, Z19214_P39, Z19214_P42, Z19214 JP43, Z19214_P44, Z19214_P45, Z19214_P46, Z19214_P47, Z19214_P49 and Z19214_P51.

Segment cluster Z19214_node_13 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35. Table 3945 below describes the starting and ending position of this segment on each transcript.

Table 3945 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214_P31.

Segment cluster Z19214_node_15 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T60. Table 3946 below describes the starting and ending position of this segment on each transcript.

Table 3946 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P49. Segment cluster Z19214_node_17 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T53. Table 3947 below describes the starting and ending position of this segment on each transcript.

Table 3947 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P43.

Segment cluster Z19214_node_19 according to the present invention B supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T59 and Z19214_T66. Table 3948 below describes the starting and ending position of this segment on each transcript.

Table 3948 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P48.

Segment cluster Z19214_node_21 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T63 and Z19214_T66. Table 3949 below describes the starting and ending position of this segment on each transcript.

Table 3949 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P51.

Segment cluster Z19214_node_23 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T58. Table 3950 below describes the starting and ending position of this segment on each transcript.

Table 3950 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z19214_node_25 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the βllowing transcript(s): Z19214_T49, Z19214_T50, Z19214_T51, Z19214_T52, Z19214_T54, Z19214_T55, Z19214_T58 and Z19214_T59. Table 3951 below describes the starting and ending position of this segment on each transcript.

Table 3951 - Segment location on ti'anscripts

This segment can be found in the following protein(s): Z19214_P42, Z19214_P44, Z19214 P45 and Z19214 P48. Segment cluster Z19214_node_28 according to the present invention is supported by 32 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z19214_T56 and Z19214_T57. Table 3952 below describes the starting and ending position of this segment on each transcript.

Table 3952 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P46 and Z19214_P47.

Segment cluster Z19214_node_34 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43, Z19214_T44 and Z19214_T46. Table 3953 below describes the starting and ending position of this segment on each transcript.

Table 3953 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36, Z19214_P37 and Z19214 P39.

Segment cluster Z19214_node_55 according to the present invention is supported by 118 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35. Table 3954 below describes the starting and ending position of this segment on each transcript.

Table 3954 - Segment location on transcripts

Z19214 T35 | 824 | 1391 |

This segment can be found in the following protein(s): Z19214_P31.

Segment cluster Z19214_node_59 according to the present invention is supported by 105 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35. Table 3955 below describes the starting and ending position of this segment on each transcript.

Table 3955 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214_P31.

Segment cluster Z19214_node_61 according to the present invention is supported by 199 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35. Table 3956 below describes the starting and ending position of this segment on each transcript.

Table 3956 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z19214_P31.

Segment cluster Z19214_node_66 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T44. Table 3957 below describes the starting and ending position of this segment on each transcript. Table 3957 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P37.

Segment cluster Z19214_node_70 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T46. Table 3958 below describes the starting and ending position of this segment on each transcript.

Table 3958 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P39.

Segment cluster Z19214_node_75 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3959 below describes the starting and ending position of this segment on each transcript.

Table 3959 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36.

Segment cluster Z19214_node_77 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3960 below describes the starting and ending position of this segment on each transcript. Table 3960 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36.

Segment cluster Z19214_node_84 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3961 below describes the starting and ending position of this segment on each transcript.

Table 3961 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP36.

Segment cluster Z19214_node_86 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3962 below describes the starting and ending position of this segment on each transcript.

Table 3962 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP36.

Segment cluster Z19214_node_92 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3963 below describes the starting and ending position of this segment on each transcript. Table 3963 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP36.

Segment cluster Z19214_node_93 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3964 below describes the starting and ending position of this segment on each transcript.

Table 3964 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z19214_node_0 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43, Z19214_T44, Z19214_T46, Z19214_T53,

Z19214_T55, Z19214_T56, Z19214_T57, Z19214_T60 and Z19214_T63. Table 3965 below describes the starting and ending position of this segment on each transcript.

Table 3965 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214_P36, Z19214_P37, Z19214_P39, Z19214_P43, Z19214_P45, Z19214_P46, Z19214_P47, Z19214JM9 and Z19214JP51.

Segment cluster Z19214_node_2 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43, Z19214_T44, Z19214_T46, Z19214_T53, Z19214_T55, Z19214_T56, Z19214_T57, Z19214_T60 and Z19214_T63. Table 3966 below describes the starting and ending position of this segment on each transcript.

Table 3966 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36, Z19214JP37, Z19214_P39, Z19214JM3, Z19214_P45, Z19214_P46, Z19214_P47, Z19214_P49 and Z19214 P51. Segment cluster Z19214_node_10 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214 J53, Z19214_T54, Z19214_T55 and Z19214_T57. Table 3967 below describes the starting and ending position of this segment on each transcript.

Table 3967 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P43, Z19214JP44, Z19214 P45 and Z19214 P47.

Segment cluster Z19214_node_14 according to the present invention is supported by 105 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44, Z19214 T46, Z19214_T49, Z19214_T50, Z19214_T51, Z19214_T52, Z19214_T53, Z19214_T54, Z19214_T55, Z19214_T56, Z19214_T57, Z19214_T60 and Z19214_T63. Table 3968 below describes the starting and ending position of this segment on each transcript.

Table 3968 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214_P31. This segment can also be found in the following protein(s): Z19214_P36, Z19214_P37, Z19214_P39, Z19214_P42, Z19214_P43, Z19214_P44, Z19214 P45, Z19214_P46, Z19214JP47, Z19214_P49 and Z19214JP51, since it is in the coding region for the corresponding transcript.

Segment cluster Z19214_node_20 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following tanscript(s): Z19214_T49, Z19214_T50, Z19214_T51, Z19214_T52,

Z19214_T54, Z19214_T55, Z19214_T59, Z19214_T63 and Z19214_T66. Table 3969 below describes the starting and ending position of this segment on each transcript.

Table 3969 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P42, Z19214_P44, Z19214_P45, Z19214JP48 and Z19214_P51.

Segment cluster Z19214_node_24 according to the present invention can be found in the following transcript(s): Z19214_T49, Z19214_T50, Z19214_T51, Z19214_T52, Z19214_T54, Z19214_T58 and Z19214_T59. Table 3970 below describes the starting and ending position of this segment on each transcript.

Table 3970 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P42, Z19214_P44 and

Z19214 P48.

Segment cluster Z19214_node_30 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3971 below describes the starting and ending position of this segment on each transcript.

Table 3971 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214_P31. This segment can also be found in the following protein(s): Z19214_P36, Z19214_P37 and Z19214_P39, since it is in the coding region for the corresponding transcript. Segment cluster Z19214__node_32 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3972 below describes the starting and ending position of this segment on each transcript.

Table 3972 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P31, Z19214JP36, Z19214_P37 and Z19214_P39.

Segment cluster Z19214_node_37 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3973 below describes the starting and ending position of this segment on each transcript.

Table 3973 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP31, Z19214_P36, Z19214 P37 and Z19214 P39.

Segment cluster Z19214_node_39 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3974 below describes the starting and ending position of this segment on each transcript. Table 3974 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP31, Z19214_P36, Z19214_P37 and Z19214_P39.

Segment cluster Z19214_node_41 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3975 below describes the starting and ending position of this segment on each transcript.

Table 3975 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP31, Z19214JP36, Z19214 P37 and Z19214 P39.

Segment cluster Z19214_node_43 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3976 below describes the starting and ending position of this segment on each transcript.

Table 3976 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P31, Z19214_P36, Z19214_P37 and Z19214_P39.

Segment cluster Z19214_node_45 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3977 below describes the starting and ending position of this segment on each transcript.

Table 3977 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP31, Z19214_P36, Z19214 P37 and Z19214 P39.

Segment cluster Z19214_node_49 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3978 below describes the starting and ending position of this segment on each transcript.

Table 3978 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP31, Z19214JP36, Z19214_P37 and Z19214_P39.

Segment cluster Z19214_node_50 according to the present invention can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3979 below describes the starting and ending position of this segment on each transcript.

Table 3979 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P31, Z19214_P36, Z19214 P37 and Z19214 P39.

Segment cluster Z19214_node_52 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35, Z19214_T43, Z19214_T44 and Z19214_T46. Table 3980 below describes the starting and ending position of this segment on each transcript.

Table 3980 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P31, Z19214_P36, Z19214 P37 and Z19214 P39. Segment cluster Z19214_node_56 according to the present invention can be found in the following transcript(s): Z19214_T35. Table 3981 below describes the starting and ending position of this segment on each transcript.

Table 3981 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214JP31.

Segment cluster Z19214_node_57 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35. Table 3982 below describes the starting and ending position of this segment on each transcript.

Table 3982 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214JP31.

Segment cluster Z19214_node_58 according to the present invention can be found in the following transcript(s): Z19214_T35. Table 3983 below describes the starting and ending position of this segment on each transcript.

Table 3983 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214_P31. Segment cluster Z19214__node_60 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T35. Table 3984 below describes the starting and ending position of this segment on each transcript.

Table 3984 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z19214_P31.

Segment cluster Z19214_node_63 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43, Z19214_T44 and Z19214_T46. Table 3985 below describes the starting and ending position of this segment on each transcript.

Table 3985 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214__P36, Z19214_P37 and Z19214 P39.

Segment cluster Z19214_node_68 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43 and Z19214_T46. Table 3986 below describes the starting and ending position of this segment on each transcript.

Table 3986 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36 and Z19214_P39.

Segment cluster Z19214_node_72 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3987 below describes the starting and ending position of this segment on each transcript.

Table 3987 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36.

Segment cluster Z19214_node_79 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3988 below describes the starting and ending position of this segment on each transcript.

Table 3988 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214JP36.

Segment cluster Z19214_node_80 according to the present invention can be found in the following transcript(s): Z19214_T43. Table 3989 below describes the starting and ending position of this segment on each transcript.

Table 3989 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36.

Segment cluster Z19214_node_82 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3990 below describes the starting and ending position of this segment on each transcript.

Table 3990 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36.

Segment cluster Z19214_node_88 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z19214_T43. Table 3991 below describes the starting and ending position of this segment on each transcript.

Table 3991 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36.

Segment cluster Z19214_node_89 according to the present invention can be found in the following transcript(s): Z19214_T43. Table 3992 below describes the starting and ending position of this segment on each transcript.

Table 3992 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36.

Segment cluster Z19214_node_90 according to the present invention can be found in the following transcript(s): Z19214_T43. Table 3993 below describes the starting and ending position of this segment on each transcript.

Table 3993 - Segment location on transcripts

This segment can be found in the following protein(s): Z19214_P36. DESCRIPTION FOR CLUSTER Z21997

Cluster Z21997 features 11 transcript(s) and 44 segment(s) of interest, the names for which are given in Tables 3994 and 3995, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 3996.

Table 3994 - Transcripts of interest

Transcript Name

Z21997 T3

Z21997 T21

Z21997 T23

Z21997 T24

Z21997 T26

Z21997 T28

Z21997 T32

Z21997 T33

Z21997 T34

Z21997_ _T35

Z21997 T38

Table 3995 - Segments of interest Z21997 node_55

Table 3996 - Proteins of interest

Cluster Z21997 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 99 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 99 and Table 3997. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, lung malignant tumors, breast malignant tumors, myosarcoma, pancreas carcinoma, skin malignancies and uterine malignancies.

Table 3997 - Normal tissue distribution

Table 3998 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z21997 features 44 segment(s), which were listed in Table 3995 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z21997_node_l according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 3999 below describes the starting and ending position of this segment on each transcript.

Table 3999 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5, Z21997_P11, Z21997_P12, Z21997_P14, Z21997_P19, Z21997 P13 and Z21997 P21.

Segment cluster Z21997_node_5 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4000 below describes the starting and ending position of this segment on each transcript.

Table 4000 - Segment location on transcripts

This segment can be found in both coding and no n- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997JP5 and Z21997JP19. This segment can also be found in the following protein(s): Z21997JP11, Z21997_P12, Z21997_P14, Z21997_P13 and Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_l l according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3. Table 4001 below describes the starting and ending position of this segment on each transcript.

Table 4001 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P2. Segment cluster Z21997_node_12 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3. Table 4002 below describes the starting and ending position of this segment on each transcript.

Table 4002 - Segment location on transcripts

This segment can be found in the following protein(s): Z21997_P2.

Segment cluster Z21997_node_13 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4003 below describes the starting and ending position of this segment on each transcript. Table 4003 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997JP11, Z21997_P12, Z21997_P14, Z21997JP13 and Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_31 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T21, Z21997_T33 and Z21997_T34. Table 4004 below describes the starting and ending position of this segment on each transcript.

Table 4004 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19.

Segment cluster Z21997_node_35 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T26, Z21997_T33, Z21997_T34 and Z21997_T38. Table 4005 below describes the starting and ending position of this segment on each transcript.

Table 4005 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P19. This segment can also be found in the following protein(s): Z21997_P14 and Z21997_P21, since it is in the coding region for the corresponding transcript. Segment cluster Z21997_node_36 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4006 below describes the starting and ending position of this segment on each transcript.

Table 4006 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P14 and Z21997JP21. This segment can also be found in the following protein(s): Z21997JP2, Z21997_P5, Z21997_P11, Z21997_P12, Z21997_P19 and Z21997_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_37 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T24 and Z21997_T32. Table 4007 below describes the starting and ending position of this segment on each transcript. Table 4007 - Segment location on transcripts

This segment can be found in the following protein(s): Z21997_P12.

Segment cluster Z21997_node_43 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4008 below describes the starting and ending position of this segment on each transcript.

Table 4008 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P12, Z21997_P14, Z21997_P13 and Z21997JP21. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5, Z21997_P11 and

Z21997_P19, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_44 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T23, Z21997_T28 and Z21997_T35. Table 4009 below describes the starting and ending position of this segment on each transcript.

Table 4009 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P13. This segment can also be found in the following protein(s): Z21997_P11, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_53 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4010 below describes the starting and ending position of this segment on each transcript.

Table 4010 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P11, Z21997_P12, Z21997_P14, Z21997_P13 and Z21997_P21. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5 and Z21997_P19, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_56 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4011 below describes the starting and ending position of this segment on each transcript.

Table 4011 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z21997_P2, Z21997_P5, Z21997_P11, Z21997_P12, Z21997_P14, Z21997_P 19, Z21997_P 13 and Z21997_P21. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z21997_node_0 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4012 below describes the starting and ending position of this segment on each transcript.

Table 4012 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5, Z21997_P11, Z21997_P12, Z21997_P14, Z21997_P19, Z21997_P13 and Z21997JP21.

Segment cluster Z21997_node_2 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4013 below describes the starting and ending position of this segment on each transcript.

Table 4013 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5, Z21997JP11, Z21997_P12, Z21997_P14, Z21997_P19, Z21997 P13 and Z21997 P21.

Segment cluster Z21997_node_3 according to the present invention can be found in the following transcript(s): Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4014 below describes the starting and ending position of this segment on each transcript. Table 4014 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5, Z21997_P11, Z21997_P12, Z21997_P14, Z21997_P19, Z21997 P13 and Z21997 P21. Segment cluster Z21997_node_4 according to the present invention can be found in the following transcript(s): Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T 33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4015 below describes the starting and ending position of this segment on each transcript.

Table 4015 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997JP5, Z21997JP11, Z21997JP12, Z21997_P14, Z21997_P19₅ Z21997 P13 and Z21997 P21.

Segment cluster Z21997_node_6 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4016 below describes the starting and ending position of this segment on each transcript.

Table 4016 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997JP5 and Z21997__P19. This segment can also be found in the following protein(s): Z21997JP11, Z21997_P12, Z21997_P14, Z21997_P13 and Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_16 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4017 below describes the starting and ending position of this segment on each transcript.

Table 4017 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997JP19. This segment can also be found in the following protein(s): Z21997_P2, Z21997JP11, Z21997_P12, Z21997_P14, Z21997_P13 and Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_l 7 according to the present invention can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997JT24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34 and Z21997_T35. Table 4018 below describes the starting and ending position of this segment on each transcript.

Table 4018 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P11, Z21997_P12, Z21997_P14 and Z21997_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_18 according to the present invention can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997JT24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34 and Z21997_T35. Table 4019 below describes the starting and ending position of this segment on each transcript.

Table 4019 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997JP11, Z21997_P12, Z21997_P14 and Z21997_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_19 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24,

Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34 and Z21997_T35. Table

4020 below describes the starting and ending position of this segment on each transcript.

Table 4020 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997JP2, Z21997_P11, Z21997_P12, Z21997_P14 and Z21997_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_21 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24,

Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34 and Z21997_T35. Table

4021 below describes the starting and ending position of this segment on each transcript.

Table 4021 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997JP11, Z21997_P12, Z21997_P14 and Z21997_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_22 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4022 below describes the starting and ending position of this segment on each transcript.

Table 4022 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997JU 1, Z21997_P12, Z21997_P14, Z21997_P13 and

Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_23 according to the present invention can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4023 below describes the starting and ending position of this segment on each transcript.

Table 4023 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997JP5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P11, Z21997JM2, Z21997_P14, Z21997_P13 and Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_24 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4024 below describes the starting and ending position of this segment on each transcript.

Table 4024 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P11, Z21997JP12, Z21997_P14, Z21997_P13 and Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_27 according to the present invention is supported by 95 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4025 below describes the starting and ending position of this segment on each transcript.

Table 4025 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z21997JP5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997JP11, Z21997JP12, Z21997_P14, Z21997_P13 and Z21997_P21, since it is in the coding region for the corresponding transcript. Segment cluster Z21997_node_30 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_ T34, Z21997_T35 and Z21997_T38. Table 4026 below describes the starting and ending position of this segment on each transcript.

Table 4026 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P5 and Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997JP11, Z21997_P12, Z21997_P14, Z21997_P13 and

Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_32 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z2l997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4027 below describes the starting and ending position of this segment on each transcript.

Table 4027 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z21997_P19. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5, Z21997 JPI l, Z21997_P12, Z21997_P14, Z21997_P13 and

Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_33 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T34. Table 4028 below describes the starting and ending position of this segment on each transcript.

Table 4028 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P 19.

Segment cluster Z21997_node_34 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4029 below describes the starting and ending position of this segment on each transcript.

Table 4029 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P19. This segment can also be found in the following protein(s):

Z21997_P2, Z21997_P5, Z21997JP11, Z21997_P12, Z21997_P14, Z21997_P13 and Z21997_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_38 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4030 below describes the starting and ending position of this segment on each transcript.

Table 4030 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P12, Z21997_P14 and Z21997_P21. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5, Z21997JP11, Z21997_P19 and Z21997_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_39 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997JT23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4031 below describes the starting and ending position of this segment on each transcript.

Table 4031 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P12, Z21997_P14 and Z21997_P21. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5, Z21997 JPI l, Z21997_P19 and Z21997JP13, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_40 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T32 and Z21997_T35. Table 4032 below describes the starting and ending position of this segment on each transcript.

Table 4032 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997JP12. This segment can also be found in the following protein(s): Z21997JP13, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_41 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T32 and Z21997_T35. Table 4033 below describes the starting and ending position of this segment on each transcript.

Table 4033 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P12 and Z21997JP13. Segment cluster Z21997_node_42 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21 , Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4034 below describes the starting and ending position of this segment on each transcript.

Table 4034 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P12, Z21997_P14, Z21997JP13 and Z21997_P21. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5, Z21997_P11 and Z21997_P19, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_45 according to the present invention can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4035 below describes the starting and ending position of this segment on each transcript. Table 4035 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P11, Z21997_P12, Z21997_P14, Z21997_P13 and Z21997_P21. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5 and

Z21997_P19, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_46 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4036 below describes the starting and ending position of this segment on each transcript.

Table 4036 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found m a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P11, Z21997_P12, Z21997_P14, Z21997_P13 and Z21997_P21. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5 and

Z21997_P19, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node__47 according to the present invention can be found in the following transcript(s): Z21997_T28 and Z21997_T35. Table 4037 below describes the starting and ending position of this segment on each transcript.

Table 4037 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P11 and Z21997_P13.

Segment cluster Z21997_node_48 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T28 and Z21997_T35. Table 4038 below describes the starting and ending position of this segment on each transcript. Table 4038 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P11 and Z21997_P13. Segment cluster Z21997_node_49 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4039 below describes the starting and ending position of this segment on each transcript.

Table 4039 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997JP11, Z21997_P12, Z21997JP14, Z21997_P13 and Z21997_P21. This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5 and Z21997_P19, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_51 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4040 below describes the starting and ending position of this segment on each transcript. Table 4040 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997JP11, Z21997JP12, Z21997_P14, Z21997_P13 and Z21997_P21.

This segment can also be found in the following protein(s): Z21997_P2, Z21997_P5 and

Z21997_P19, since it is in the coding region for the corresponding transcript.

Segment cluster Z21997_node_54 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4041 below describes the starting and ending position of this segment on each transcript. Table 4041 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P2, Z21997_P5, Z21997JP11, Z21997_P12, Z21997_P14, Z21997_P 19, Z21997_P 13 and Z21997_P21.

Segment cluster Z21997_node_55 according to the present invention is supported by 89 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z21997_T3, Z21997_T21, Z21997_T23, Z21997_T24, Z21997_T26, Z21997_T28, Z21997_T32, Z21997_T33, Z21997_T34, Z21997_T35 and Z21997_T38. Table 4042 below describes the starting and ending position of this segment on each transcript.

Table 4042 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z21997_P2, Z21997_P5, Z21997JP11, Z21997_P12, Z21997_P14, Z21997_P19, Z21997_P13 and Z21997_P21.

DESCRIPTION FOR CLUSTER Z25166 Cluster Z25166 features 3 transcript(s) and 34 segment(s) of interest, the names for which are given in Tables 1 and 2, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4045.

Table 4043 - Transcripts of interest

TranscriptName

Z25166 T2

Z25166 T9

Z25166 TlO

Table4044-Segmentsofinterest

SegmentName

Z25166 node 0

Z25166 node 14

Z25166 node 15

Z25166 node 16

Z25166 node 21

Z25166 node 23

Z25166 node 24

Z25166 node 25

Z25166 node 26

Z25166 node 28

Z25166 node 29

Z25166 node 30

Z25166 node 35

Z25166 node 44

Z25166 node 1

Z25166 node 2

Z25166 node 3

Z25166 node 5

Z25166 node 7

Z25166 node 9

Z25166 node 12

Z25166 node 17

Z25166 node 18

Z25166 node 19

Z25166 node 31

Z25166 node 33

Z25166 node 34

Z25166 node 36

Z25166 node 37 Z25166 node 38

Z25166 node 40

Z25166 node 41

Z25166 node 42

Z25166 node 43

Table 4045 - Proteins of interest

These sequences are variants of the known protein Nuclear ubiquitous casein and cyclin- dependent kinases substrate (SwissProt accession identifier NUKS_HUMAN), referred to herein as the previously known protein.

The sequence for protein Nuclear ubiquitous casein and cyclin-dependent kinases substrate is given at the end of the application, as "Nuclear ubiquitous casein and cyclin- dependent kinases substrate amino acid sequence". Protein Nuclear ubiquitous casein and cyclin-dependent kinases substrate localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster Z25166 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 100 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 100 and Table 4046. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: bone malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, ovarian carcinoma and gastric carcinoma.

Table 4046 - Normal tissue distribution

Table 4047 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z25166 features 34 segment(s), which were listed in Table 4044 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z25166_node_0 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2. Table 4048 below describes the starting and ending position of this segment on each transcript.

Table 4048 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z25166_P2.

Segment cluster Z25166_node_14 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T9 and Z25166_T10. Table 4049 below describes the starting and ending position of this segment on each transcript.

Table 4049 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_15 according to the present invention is supported by 203 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4050 below describes the starting and ending position of this segment on each transcript.

Table 4050 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166JP4. This segment can also be found in the following protein(s): Z25166_P2 and Z25166_P3, since it is in the coding region for the corresponding transcript. Segment cluster Z25166_node_16 according to the present invention is supported by 5 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z25166_T2 and Z25166_T10. Table 4051 below describes the starting and ending position of this segment on each transcript.

Table 4051 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166 P4. This segment can also be found in the following protein(s): Z25166_P2, since it is in the coding region for the corresponding transcript.

Segment cluster Z25166_node_21 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4052 below describes the starting and ending position of this segment on each transcript.

Table 4052 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2. This segment can also be found in the following protein(s): Z25166_P3 and Z25166_P4, since it is in the coding region for the corresponding transcript.

Segment cluster Z25166_node_23 according to the present invention is supported by 198 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4053 below describes the starting and ending position of this segment on each transcπpt.

Table 4053 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_24 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4054 below describes the starting and ending position of this segment on each transcript.

Table 4054 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_25 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4055 below describes the starting and ending position of this segment on each transcript.

Table 4055 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_26 according to the present invention is supported by 116 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4056 below describes the starting and ending position of this segment on each transcript.

Table 4056 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_28 according to the present invention is supported by 316 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4057 below describes the starting and ending position of this segment on each transcript.

Table 4057 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4. Segment cluster Z25166_node_29 according to the present invention is supported by 203 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4058 below describes the starting and ending position of this segment on each transcript.

Table 4058 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_30 according to the present invention is supported by 223 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4059 below describes the starting and ending position of this segment on each transcript.

Table 4059 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_35 according to the present invention is supported by 298 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4060 below describes the starting and ending position of this segment on each transcript. Table 4060 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_44 according to the present invention is supported by 198 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4061 below describes the starting and ending position of this segment on each transcript.

Table 4061 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166JP3 and Z25166JP4.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z25166_node_ l according to the present invention can be found in the following transcript(s): Z25166_T2. Table 4062 below describes the starting and ending position of this segment on each transcript.

Table 4062 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2.

Segment cluster Z25166_node_2 according to the present invention can be found in the following transcript(s): Z25166_T2. Table 4063 below describes the starting and ending position of this segment on each transcript.

Table 4063 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2.

Segment cluster Z25166_node_3 according to the present invention is supported by 199 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2. Table 4064 below describes the starting and ending position of this segment on each transcript.

Table 4064 - Segment location on transcripts

This segment can be found in the following protein(s): Z25166_P2.

Segment cluster Z25166_node_5 according to the present invention can be found in the following transcript(s): Z25166_T2. Table 4065 below describes the starting and ending position of this segment on each transcript.

Table 4065 - Segment location on transcripts

This segment can be found in the following protein(s): Z25166_P2.

Segment cluster Z25166_node_7 according to the present invention is supported by 189 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z25166_T2. Table 4066 below describes the starting and ending position of this segment on each transcript.

Table 4066 - Segment location on transcripts

This segment can be found in the following protein(s): Z25166_P2.

Segment cluster Z25166_node_9 according to the present invention is supported by 192 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2. Table 4067 below describes the starting and ending position of this segment on each transcript.

Table 4067 - Segment location on transcripts

This segment can be found in the following protein(s): Z25166_P2.

Segment cluster Z25166_node_12 according to the present invention is supported by 187 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2. Table 4068 below describes the starting and ending position of this segment on each transcript.

Table 4068 - Segment location on transcripts

This segment can be found in the following protein(s): Z25166_P2.

Segment cluster Z25166_node_17 according to the present invention is supported by 168 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4069 below describes the starting and ending position of this segment on each transcript.

Table 4069 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2. This segment can also be found in the following protein(s): Z25166_P3 and Z25166_P4, since it is in the coding region for the corresponding transcript.

Segment cluster Z25166_node_18 according to the present invention can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4070 below describes the starting and ending position of this segment on each transcript.

Table 4070 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2. This segment can also be found in the following protein(s): Z25166_P3 and Z25166_P4, since it is in the coding region for the corresponding transcript.

Segment cluster Z25166_node_l 9 according to the present invention is supported by 179 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4071 below describes the starting and ending position of this segment on each transcript.

Table 4071 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2. This segment can also be found in the following protein(s): Z25166_P3 and Z25166_P4, since it is in the coding region for the corresponding transcript.

Segment cluster Z25166_node_31 according to the present invention is supported by 197 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4072 below describes the starting and ending position of this segment on each transcript.

Table 4072 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4. Segment cluster Z25166_node_33 according to the present invention is supported by 205 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4073 below describes the starting and ending position of this segment on each transcript.

Table 4073 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_34 according to the present invention is supported by 227 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4074 below describes the starting and ending position of this segment on each transcript.

Table 4074 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_36 according to the present invention is supported by 246 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4075 below describes the starting and ending position of this segment on each transcript.

Table 4075 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node__37 according to the present invention is supported by 258 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4076 below describes the starting and ending position of this segment on each transcript.

Table 4076 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_38 according to the present invention can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4077 below describes the starting and ending position of this segment on each transcript.

Table 4077 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4. Segment cluster Z25166_node_40 according to the present invention can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4078 below describes the starting and ending position of this segment on each transcript. Table 4078 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_41 according to the present invention is supported by 225 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4079 below describes the starting and ending position of this segment on each transcript.

Table 4079 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_42 according to the present invention is supported by 216 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4080 below describes the starting and ending position of this segment on each transcript.

Table 4080 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166JP2, Z25166_P3 and Z25166_P4.

Segment cluster Z25166_node_43 according to the present invention is supported by 207 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z25166_T2, Z25166_T9 and Z25166_T10. Table 4081 below describes the starting and ending position of this segment on each transcript.

Table 4081 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z25166_P2, Z25166_P3 and Z25166_P4.

DESCRIPTION FOR CLUSTER Z40494

Cluster Z40494 features 2 transcript(s) and 22 segment(s) of interest, the names for which are given in Tables 4082 and 4083, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4084.

Table 4082 - Transcripts of interest

Transcript Name

Z40494 Tl

Z40494 TI l Table 4083 - Segments of interest

Segment Name

Z40494 node 0

Z40494 node 2

Z40494 node 11

Z40494 node 12

Z40494 node 16

Z40494 node 19

Z40494 node 20

Z40494 node 21

Z40494 node 22

Z40494 node 24

Z40494 node 1

Z40494 node 3

Z40494 node 4

Z40494 node 6

Z40494 node 8

Z40494 node 13

Z40494 node 14

Z40494 node 17

Z40494 node 18

Z40494 node 23

Z40494 node 26

Z40494 node 28

Table 4084 - Proteins of interest

Cluster Z40494 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the yaxis of Figure 101 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 101 and Table 4085. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, malignant tumors involving the lymph nodes, myosarcoma, pancreas carcinoma and skin malignancies.

Table 4085 - Normal tissue distribution

Table 4086 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z40494 features 22 segment(s), which were listed in Table 4083 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z40494_node_0 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1 and Z40494_Tl l. Table 4087 below describes the starting and ending position of this segment on each transcript.

Table 4087 - Segment location on transcripts

This segment can be found in the following protein(s): Z40494_P2.

Segment cluster Z40494_node_2 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1 and Z40494_T11. Table 4088 below describes the starting and ending position of this segment on each transcript. Table 4088 - Segment location on transcripts

This segment can be found in the following protein(s): Z40494JP2.

Segment cluster Z40494_node_l 1 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4089 below describes the starting and ending position of this segment on each transcript.

Table 4089 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_12 according to the present invention is supported by 63 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4090 below describes the starting and ending position of this segment on each transcript.

Table 4090 - Segment location on transcripts

This segment can be found in a non-coding region of transcriρt(s) that are related to the following protein(s): Z40494_P2. Segment cluster Z40494_node_l 6 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4091 below describes the starting and ending position of this segment on each transcript.

Table 4091 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_19 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4092 below describes the starting and ending position of this segment on each transcript.

Table 4092 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_20 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4093 below describes the starting and ending position of this segment on each transcript.

Table 4093 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494JP2.

Segment cluster Z40494_node_21 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4094 below describes the starting and ending position of this segment on each transcript.

Table 4094 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_22 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40494_T1. Table 4095 below describes the starting and ending position of this segment on each transcript.

Table 4095 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_24 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4096 below describes the starting and ending position of this segment on each transcript. Table 4096 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z40494_node_l according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1 and Z4O494_T11. Table 4097 below describes the starting and ending position of this segment on each transcript. Table 4097 - Segment location on transcripts

This segment can be found in the following protein(s): Z40494_P2.

Segment cluster Z40494_node_3 according to the present invention can be found in the following transcript(s): Z4O494_T1 and Z40494_T1 1. Table 4098 below describes the starting and ending position of this segment on each transcript.

Table 4098 - Segment location on transcripts

This segment can be found in the following protein(s): Z40494_P2.

Segment cluster Z40494_node_4 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1 and Z4O494_T11. Table 4099 below describes the starting and ending position of this segment on each transcript.

Table 4099 - Segment location on transcripts

This segment can be found in the following protein(s): Z40494_P2.

Segment cluster Z40494_node_6 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z40494_T1 and Z4O494_T11. Table 4100 below describes the starting and ending position of this segment on each transcript.

Table 4100 - Segment location on transcripts

This segment can be found in the following protein(s): Z40494_P2.

Segment cluster Z40494_node_8 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1 and Z4O494_T11. Table 4101 below describes the starting and ending position of this segment on each transcript.

Table 4101 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_l 3 according to the present invention can be found in the following transcript(s): Z4O494_T1. Table 4102 below describes the starting and ending position of this segment on each transcript.

Table 4102 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494J^>2.

Segment cluster Z40494_node_14 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4103 below describes the starting and ending position of this segment on each transcript.

Table 4103 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_17 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4104 below describes the starting and ending position of this segment on each transcript.

Table 4104 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_l 8 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4105 below describes the starting and ending position of this segment on each transcript.

Table 4105 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : Z40494_P2.

Segment cluster Z40494_node_23 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T1. Table 4106 below describes the starting and ending position of this segment on each transcript.

Table 4106 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2. Segment cluster Z40494_node_26 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T11. Table 4107 below describes the starting and ending position of this segment on each transcript.

Table 4107 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

Segment cluster Z40494_node_28 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z4O494_T11. Table 4108 below describes the starting and ending position of this segment on each transcript. Table 4108 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z40494_P2.

DESCRIPTION FOR CLUSTER Z44716 Cluster Z44716 features 9 transcript(s) and 34 segment(s) of interest, the names for which are given in Tables 4109 and 4110, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4111.

Table 4109 - Transcripts of interest

TranscriptName

Z44716 T4

Z44716 T7

Z44716_ _T9

Z44716 T25

Z44716 T32

Z44716 T34

Z44716 T35

Z44716 T40

Z44716 T42

Table4110-Segmentsofinterest

Z44716 node 31

Z44716 node 41

Z44716 node 42

Z44716 node 44

Z44716 node 46

Z44716 node 53

Z44716 node 54

Z44716 node 56

Z44716 node 60

Z44716_ node 62

Z44716 node 67

Table 4111 - Proteins of interest

These sequences are variants of the known protein Enhancer of zeste homobg 2 (SwissProt accession identifier EZH2_HUMAN; known also according to the synonyms ENX- 1), referred to herein as the previously known protein.

Protein Enhancer of zeste homolog 2 is known or believed to have the following function(s): May be involved in the regulation of gene transcription and chromatin structure. The sequence for protein Enhancer of zeste homolog 2 is given at the end of the application, as "Enhancer of zeste homolog 2 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4112.

Table 4112 -Amino acid mutations for Known Protein

Protein Enhancer of zeste homolog 2 localization is believed to be Nuclear (Probable). The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: establishment and/or maintenance of chromatin architecture; transcription regulation, which are annotation(s) related to Biological Process; DNA binding, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from ^ttpV/www.ncbi.nlm.nih.gov/projects/LocusLinl^.

Cluster Z44716 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 102 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 102 and Table 4113. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and myosarcoma.

Table 4113 - Normal tissue distribution

Table 4114 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 4115.

Table 4115 - Oligonucleotides related to this cluster

As noted above, cluster Z44716 features 34 segment(s), which were listed in Table 4110 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z44716_node_0 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T7, Z44716_T9 and Z44716_T40. Table 4116 below describes the starting and ending position of this segment on each transcript.

Table 4116 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P5, Z44716_P7 and Z44716_P22. Segment cluster Z44716_node_4 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4. Table 4117 below describes the starting and ending position of this segment on each transcript.

Table 4117 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z44716JP1.

Segment cluster Z44716_node_10 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T40. Table 4118 below describes the starting and ending position of this segment on each transcript.

Table 4118 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P5 and Z44716JP7. This segment can also be found in the following protein(s): Z44716_P1 and Z44716_P22, since it is in the coding region for the corresponding transcript.

Segment cluster Z44716_node_14 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): Z44716_T40. Table 41 19 below describes the starting and ending position of this segment on each transcript.

Table 4119 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P22.

Segment cluster Z44716_node_16 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T7 and Z44716_T9. Table 4120 below describes the starting and ending position of this segment on each transcript.

Table 4120 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P5. This segment can also be found in the following protein(s): Z44716_P7, since it is in the coding region for the corresponding transcript.

Segment cluster Z44716_node_20 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7 and Z44716_T9. Table 4121 below describes the starting and ending position of this segment on each transcript.

Table 4121 - Segment location on transcripts

I Z44716 T9 I I 1002 ] I 1122 I

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5 and Z44716_P7.

Segment cluster Z44716_node_23 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7 and Z44716_T9. Table 4122 below describes the starting and ending position of this segment on each transcript.

Table 4122 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5 and Z44716 P7.

Segment cluster Z44716_node_27 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7 and Z44716_T9. Table 4123 below describes the starting and ending position of this segment on each transcript.

Table 4123 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716JP1, Z44716_P5 and Z44716 P7. Segment cluster Z44716_node_30 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T25. Table 4124 below describes the starting and ending position of this segment on each transcript.

Table 4124 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P17.

Segment cluster Z44716_node_38 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T25. Table 4125 below describes the starting and ending position of this segment on each transcript.

Table 4125 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P17. This segment can also be found in the following protein(s): Z44716_P1, Z44716_P5 and Z44716_P7, since it is in the coding region for the corresponding transcript.

Segment cluster Z44716_node_49 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T25. Table 4126 below describes the starting and ending position of this segment on each transcript.

Table 4126 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5, Z44716 P7 and Z44716 P17.

Segment cluster Z44716_node_51 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T25. Table 4127 below describes the starting and ending position of this segment on each transcript.

Table 4127 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5, Z44716 P7 and Z44716 P17.

Segment cluster Z44716__node_57 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T42. Table 4128 below describes the starting and ending position of this segment on each transcript.

Table 4128 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z44716_node_59 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T32, Z44716_T34 and Z44716_T35. Table 4129 below describes the starting and ending position of this segment on each transcript.

Table 4129 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z44716_node_61 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T34. Table 4130 below describes the starting and ending position of this segment on each transcript.

Table 4130 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z44716_node_66 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9, Z44716_T25, Z44716_T32, Z44716_T34 and Z44716_T35. Table 4131 below describes the starting and ending position of this segment on each transcript.

Table 4131 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716JP5, Z44716 P7 and Z44716 P17.

Segment cluster Z44716_node_68 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9, Z44716_T25, Z44716_T32, Z44716_T34 and Z44716_T35. Table 4132 below describes the starting and ending position of this segment on each transcript.

Table 4132 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z44716JP1, Z44716_P5, Z44716_P7 and Z44716_P17. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z44716_node_l according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T7, Z44716_T9 and Z44716_T40. Table 4133 below describes the starting and ending position of this segment on each transcript.

Table 4133 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P5, Z44716JP7 and Z44716_P22.

Segment cluster Z44716_node_2 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T7, Z44716_T9 and Z44716_T40. Table 4134 below describes the starting and ending position of this segment on each transcript.

Table 4134 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P5, Z44716JP7 and Z44716_P22. Segment cluster Z44716_node_12 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T40. Table 4135 below describes the starting and ending position of this segment on each transcript.

Table 4135 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P5. This segment can also be found in the following protein(s): Z44716_P1, Z44716_P7 and Z44716JP22, since it is in the coding region for the corresponding transcript.

Segment cluster Z44716_node_13 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7 and Z44716_T40. Table 4136 below describes the starting and ending position of this segment on each transcript.

Table 4136 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P5. This segment can also be found in the following protein(s): Z44716_P1 and Z44716_P22, since it is in the coding region for the corresponding transcript. Segment cluster Z44716_node_18 according to the present invention is supported by 32 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7 and Z44716_T9. Table 4137 below describes the starting and ending position of this segment on each transcript.

Table 4137 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716JP5 and Z44716_P7.

Segment cluster Z44716_node_25 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7 and Z44716_T9. Table 4138 below describes the starting and ending position of this segment on each transcript.

Table 4138 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5 and Z44716 P7.

Segment cluster Z44716_node_31 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T25. Table 4139 below describes the starting and ending position of this segment on each transcript. Table 4139 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716_P17. This segment can also be found in the following protein(s):

Z44716_P1, Z44716_P5 and Z44716 P7, since it is in the coding region for the corresponding transcript.

Segment cluster Z44716_node_41 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T25. Table 4140 below describes the starting and ending position of this segment on each transcript.

Table 4140 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716JP5, Z44716 P7 and Z44716 P17.

Segment cluster Z44716_node_42 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T25. Table 4141 below describes the starting and ending position of this segment on each transcript. Table 4141 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5, Z44716_P7 and Z44716_P17.

Segment cluster Z44716_node_44 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T25. Table 4142 below describes the starting and ending position of this segment on each transcript.

Table 4142 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5, Z44716 P7 and Z44716 P17.

Segment cluster Z44716_node_46 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9 and Z44716_T25. Table 4143 below describes the starting and ending position of this segment on each transcript.

Table 4143 - Segment location on transcripts

This segment can be found in the following ρrotein(s): Z44716_P1, Z44716_P5, Z44716_P7 and Z44716_P17.

Segment cluster Z44716_node_53 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T42. Table 4144 below describes the starting and ending position of this segment on each transcript.

Table 4144 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z44716_node_54 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9, Z44716_T25 and Z44716_T42. Table 4145 below describes the starting and ending position of this segment on each transcript.

Table 4145 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716JP5, Z44716 P7 and Z44716 P17. Segment cluster Z44716_node_56 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9, Z44716_T25 and Z44716_T42. Table 4146 below describes the starting and ending position of this segment on each transcript.

Table 4146 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5, Z44716 P7 and Z44716 P17.

Segment cluster Z44716__node_60 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9_> Z44716_T25, Z44716_T32, Z44716_T34 and Z44716_T35. Table 4147 below describes the starting and ending position of this segment on each transcript.

Table 4147 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716_P5, Z44716_P7 and Z44716J^>17.

Segment cluster Z44716_node_62 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9, Z44716_T25, Z44716_T32, Z44716_T34 and Z44716_T35. Table 4148 below describes the starting and ending position of this segment on each transcript.

Table 4148 - Segment location on transcripts

This segment can be found in the following protein(s): Z44716_P1, Z44716JP5, Z44716 P7 and Z44716 P17.

Segment cluster Z44716jαode_67 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z44716_T4, Z44716_T7, Z44716_T9, Z44716_T25,

Z44716_T32, Z44716JD4 and Z44716_T35. Table 4149 below describes the starting and ending position of this segment on each transcript.

Table 4149 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z44716JP1, Z44716_P5, Z44716_P7 and Z44716_P17.

Expression of Homo sapiens enhancer of zeste homolog 2 (Drosophila) (EZH2) Z44716 transcripts which are detectable by amplicon as depicted in sequence name Z44716 segl6 in normal and cancerous lung tissues

Expression of Homo sapiens enhancer of zeste homolog 2 (Drosophila) (EZH2) transcripts detectable by or according to Z44716 segl6, Z44716 seglδ amplicon(s) and Z44716 segl6F and Z44716 segl6R primers was measured by real time PCR. In parallel the expression of four housekeeping genes -PBGD (GenBank Accession No. BCOl 9323; amplicon - PBGD- amplicon), HPRTl (GenBank Accession No. NM_000194; amplicon - HPRTl -amplicon), Ubiquitin (GenBank Accession No. BC000449; amplicon - Ubiquitin-amplicon) and SDHA (GenBank Accession No. NM_004168; amplicon - SDHA- amplicon) was measured similarly. For each RT sample, the expression of the above amplicon was normalized to the geometric mean of the quantities of the housekeeping genes. The normalized quantity of each RT sample was then divided by the median of the quantities of the normal post-mortem (PM) samples (Sample Nos. 47-50, 90-93, 96-99, Table 1 above), to obtain a value of fold up-regulation βr each sample relative to median of the normal PM samples. Figure 103 is a histogram showing over expression of the above- indicated EZH2 transcripts in cancerous lung samples relative to the normal samples. Values represent the average of duplicate experiments. Error bars indicate the minimal and maximal values obtained.

As is evident from Figure 103, the expression of EZH2 transcripts detectable by the above amplicon(s) in cancer samples was higher than in the non-cancerous samples (Sample Nos. 47-50, 90-93, 96-99 Table 1). Notably an over- expression of at least 5 fold was found in 1 out of 15 adenocarcinoma samples, 2 out of 16 squamous cell carcinoma samples, 2 out of 4 large cell carcinoma samples and in 7 out of 8 small cell carcinoma samples. Primer pairs are also optionally and preferably encompassed within the present invention; for example, for the above experiment, the following primer pair was used as a non- limiting illustrative example only of a suitable primer pair: Z44716 seglόF forward primer; and Z44716 segl 6R reverse primer. The present invention also preferably encompasses any amplicon obtained through the use of any suitable primer pair; for example, for the above experiment, the following amplicon was obtained as a non- limiting illustrative example only of a suitable amplicon: Z44716 seglό.

Forward primer- Z44716 seglόF: ACAGTTTTTACTTGGAACCAGCCT Reverse primer- Z44716 seglόR: ACTGGGAGCTGGAGAGGGA

Amplicon:

ACAGTTTTTACTTGGAACCAGCCTTCTGCCAAGAGTCTCAGTTTGGTTGTGTACTCC TACAACTACTATTTTTGGCTTGACTTCCCTCTCCAGCTCCCAGT

DESCRIPTION FOR CLUSTER Rl 3007

Cluster R13007 features 4 transcript(s) and 28 segment(s) of interest, the names for which are given in Tables 4150 and 4151, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4152. Table 4150 - Transcripts of interest

Transcript Name

Rl 3007 T7

Rl 3007 T9

R13007 TlO

R13007 T18

Table 4151 - Segments of interest

SegmentName

Rl3007 node 0

R13007 node 3

Rl3007 node 5

R13007 node 6

Rl3007 node 27 R13007 node 33

R13007 node 43

Rl3007 node 11

R13007 node 12

Rl3007 node 13

R13007 node 22

R13007 node 24

R13007 node 25

R13007 node 28

R13007 node 29

R13007 node 34

Rl3007 node 36

R13007 node 37

Rl3007 node 38

Rl3007 node 39

Rl3007 node 40

Rl3007 node 41

Rl3007 node 42

R13007 node 44

R13007 node 45

Rl3007 node 46

R13007 node 47

Rl3007 node 49

Table 4152 - Proteins of interest

These sequences are variants of the known protein Calponin Hl, smooth muscle (SwissProt accession identifier CLP1_HUMAN; known also according to the synonyms Basic calponin; Calponin 1), referred to herein as the previously known protein.

Protein Calponin Hl, smooth muscle is known or believed to have the following function(s): Thin filament- associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). The sequence for protein Calponin Hl, smooth muscle is given at the end of the application, as "Calponin Hl, smooth muscle amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4153.

Table 4153 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: smooth muscle contraction, which are annotation(s) related to Biological Process; actin binding; calmodulin binding, which are annotation(s) related to Molecular Function; and cytoskeleton, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locus link, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster Rl 3007 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 104 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 104 and Table 4154. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: myosarcoma and pancreas carcinoma.

Table 4154 - Normal tissue distribution

Table 4155 - P values and ratios for expression in cancerous tissue

As noted above, cluster Rl 3007 features 28 segment(s), which were listed in Table 4151 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster R13007__node_0 according to the present invention is supported by 227 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T9. Table 4156 below describes the starting and ending position of this segment on each transcript.

Table 4156 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R13007_P8.

Segment cluster R13007_node_3 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T9. Table 4157 below describes the starting and ending position of this segment on each transcript.

Table 4157 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R13007_P8.

Segment cluster R13007_node_5 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7 and R13007_T10. Table 4158 below describes the starting and ending position of this segment on each transcript.

Table 4158 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R13007_P8 and R13007_P10.

Segment cluster R13007_node_6 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T10. Table 4159 below describes the starting and ending position of this segment on each transcript.

Table 4159 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P10.

Segment cluster Rl 3007_node_27 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T18. Table 4160 below describes the starting and ending position of this segment on each transcript.

Table 4160 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R13007_P14.

Segment cluster R13007_node_33 according to the present invention is supported by 209 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4161 below describes the starting and ending position of this segment on each transcript. Table 4161 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

Segment cluster R13007_node_43 according to the present invention is supported by 197 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4162 below describes the starting and ending position of this segment on each transcript.

Table 4162 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R13007_node_l 1 according to the present invention is supported by 235 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s) : R13007_T7, R13007_T9 and R13007_T10. Table 4163 below describes the starting and ending position of this segment on each transcript.

Table 4163 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R13007_P8. This segment can also be found in the following protein(s): R13007_P10, since it is in the coding region for the corresponding transcript.

Segment cluster R13007_node_12 according to the present invention is supported by 240 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9 and R13007_T10. Table 4164 below describes the starting and ending position of this segment on each transcript.

Table 4164 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R13007_P8. This segment can also be found in the following protein(s): R13007_P10, since it is in the coding region for the corresponding transcript.

Segment cluster R13007_node_13 according to the present invention is supported by 241 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9 and R13007_T10. Table 4165 below describes the starting and ending position of this segment on each transcript.

Table 4165 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8 and R13007_P10.

Segment cluster R13007_node_22 according to the present invention is supported by 222 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9 and R13007_T10. Table 4166 below describes the starting and ending position of this segment on each transcript.

Table 4166 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8 and R13007_P10.

Segment cluster Rl 3007_node_24 according to the present invention is supported by 187 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9 and R13007_T10. Table 4167 below describes the starting and ending position of this segment on each transcript.

Table 4167 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8 and R13OO7_P1O.

Segment cluster R13007_node_25 according to the present invention is supported by 165 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9 and R13007_T10. Table 4168 below describes the starting and ending position of this segment on each transcript.

Table 4168 - Segment location on transcripts

This segment can be found in the following protein(s): R13007JP8 and R13007_P10.

Segment cluster R13007_node_28 according to the present invention is supported by 199 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4169 below describes the starting and ending position of this segment on each transcript.

Table 4169 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcripts) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R13007_P14. This segment can also be found in the following protein(s): R13007_P8 and R13007_P10, since it is in the coding region for the corresponding transcript. Segment cluster R13007_node_29 according to the present invention can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4170 below describes the starting and ending position of this segment on each transcript.

Table 4170 - Segment location on transcripts

This segment can be found in the following protein(s): R13007 P8, R13007_P10 and R13007 P14.

Segment cluster R13007_node_34 according to the present invention can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4171 below describes the starting and ending position of this segment on each transcript.

Table 4171 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8, R13007_P10 and R13007 P14.

Segment cluster R13007_node_36 according to the present invention is supported by 174 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4172 below describes the starting and ending position of this segment on each transcript.

Table 4172 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8, R13007JP10 and R13007_P14.

Segment cluster R13007__node_37 according to the present invention is supported by 169 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4173 below describes the starting and ending position of this segment on each transcript.

Table 4173 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8, R13007_P10 and R13007 P14.

Segment cluster R13007_node_38 according to the present invention can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4174 below describes the starting and ending position of this segment on each transcript.

Table 4174 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

Segment cluster R13007_node_39 according to the present invention is supported by 204 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4175 below describes the starting and ending position of this segment on each transcript.

Table 4175 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8, R13007_P10 and R13007 P14.

Segment cluster R13007_node_40 according to the present invention is supported by 189 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4176 below describes the starting and ending position of this segment on each transcript.

Table 4176 - Segment location on transcripts

This segment can be found in the following protein(s): R13007_P8, R13007_P10 and R13007 P14. Segment cluster R13007_node_41 according to the present invention can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4177 below describes the starting and ending position of this segment on each transcript.

Table 4177 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

Segment cluster R13007__node_42 according to the present invention is supported by 166 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4178 below describes the starting and ending position of this segment on each transcript.

Table 4178 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

Segment cluster R13007_node_44 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4179 below describes the starting and ending position of this segment on each transcript. Table 4179 ~ Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

Segment cluster R13007_node_45 according to the present invention is supported by 178 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4180 below describes the starting and ending position of this segment on each transcript. Table 4180 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

Segment cluster R13007_node_46 according to the present invention is supported by 174 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R.13007_T18. Table 4181 below describes the starting and ending position of this segment on each transcript.

Table 4181 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

Segment cluster R13007_node_47 according to the present invention is supported by 136 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4182 below describes the starting and ending position of this segment on each transcript.

Table 4182 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R13007_P8, R13007_P10 ani R13007_P14.

Segment cluster R13007_node_49 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R13007_T7, R13007_T9, R13007_T10 and R13007_T18. Table 4183 below describes the starting and ending position of this segment on each transcript.

Table 4183 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R13007_P8, R13007_P10 and R13007_P14.

DESCRIPTION FOR CLUSTER AA091457

Cluster AA091457 features 13 transcript(s) and 26 segment(s) of interest, the names for which are given in Tables 4184 and 4185, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4186. Table 4184 - Transcripts of interest

Transcript Name

AA091457 TO

AA091457 Tl

AA091457 T2

AA091457 T4

AA091457 T5

AA091457 T6

AA091457 T7

AA091457 T8

AA091457 T9

AA091457 T12

AA091457 T14

AA091457 T15

AA091457 T16

Table 4185 - Segments of interest

Segment Name

AA091457 node 0

AA091457 node 3

AA091457 node 5

AA091457 node 6 AA091457 node 7

AA091457 node 8

AA091457 node 9

AA091457 node 15

AA091457 node 17

AA091457 node 19

AA091457 node 33

AA091457 node 34

AA091457 node 35

AA091457_ node _39

AA091457 node 2

AA091457 node 11

AA091457 node 13

AA091457 node 20

AA091457 node 22

AA091457 node 24

AA091457 node 25

AA091457 node 27

AA091457 node 28

AA091457 node 30

AA091457 node 36

AA091457 node 37

Table 4186 - Proteins of interest

Cluster AA091457 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 105 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 105 and Table 4187. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 4187 - Normal tissue distribution

Table 4188 - P values and ratios for expression in cancerous tissue

As noted above, cluster AA091457 features 26 segment(s), which were listed in Table 4185 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster AA091457_node_0 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457JI5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AAO91457_T12, AA091457_T14, AA091457_T15 and AA091457_T16. Table 4189 below describes the starting and ending position of this segment on each transcript. Table 4189 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457_P5, AA091457JP8 and AA091457_P6.

Segment cluster AA091457_node_3 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T16. Table 4190 below describes the starting and ending position of this segment on each transcript.

Table 4190 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster AA091457_node_5 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4191 below describes the starting and ending position of this segment on each transcript.

Table 4191 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457JP5, AA091457JP8 and AA091457_P6.

Segment cluster AA091457_node_6 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T12_s AA091457_T14 and AA091457_T15. Table 4192 below describes the starting and ending position of this segment on each transcript.

Table 4192 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AAO91457_P1, AA091457_P2, AA091457JP3, AA091457JP4, AA091457_P8 and AA091457_P6.

Segment cluster AA091457_node_7 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_TO, AAO91457_T1, AA091457_T2, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4193 below describes the starting and ending position of this segment on each transcript.

Table 4193 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AAO91457_P1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457 P8 and AA091457 P6.

Segment cluster AA091457_node_8 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457__T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4194 below describes the starting and ending position of this segment on each transcript. Table 4194 - Segment location on transcripts

This segment can be found in a non-coding region of transcπpt(s) that are related to the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457 P8 and AA091457 P6.

Segment cluster AA091457_node_9 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s) : AA091457_T0, AA091457_T1, AA091457_T2, AA091457_T4, AAO91457_T5, AA091457_T6, AA091457_T7, AA091457_T8,

AA091457_T12, AA091457_T14 and AA091457_T15. Table 4195 below describes the starting and ending position of this segment on each transcript.

Table 4195 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457_P8. This segment can also be found in the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4 and AA091457JP6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_15 according to the present invention is supported by 21 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AA091457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457JN4 and AA091457_T15. Table 4196 below describes the starting and ending position of this segment on each transcript.

Table 4196 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457JP5 and AA091457_P8. This segment can also be found in the following protein(s): AA091457JP1, AA091457_P2, AA091457JP3, AA091457_P4 and AA091457_P6, since it is in the coding region for the corresponding transcript. Segment cluster AA091457_node_17 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457JT7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4197 below describes the starting and ending position of this segment on each transcript.

Table 4197 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457_P8. This segment can also be found in the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457_P5 and AA091457_P6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_19 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4198 below describes the starting and ending position of this segment on each transcript. Table 4198 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457_P8. This segment can also be found in the following protein(s): AAO91457_P1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457_P5 and AA091457JP6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_33 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4199 below describes the starting and ending position of this segment on each transcript. Table 4199 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457_P8. This segment can also be found in the following protein(s): AA091457JP1, AA091457_P2, AA091457JP3, AA091457_P4, AA091457JP5 and AA091457JP6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_34 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T6, AA091457_T14 and AA091457_T15. Table 4200 below describes the starting and ending position of this segment on each transcript.

Table 4200 - Segment location on transcripts

This segment can be found in the following protein(s): AA091457_P2 and AA091457 P6.

Segment cluster AA091457_node_35 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9 and AA091457_T12. Table 4201 below describes the starting and ending position of this segment on each transcript. Table 4201 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457_P2 and AA091457_P8. This segment can also be found in the following protein(s): AAO91457_P1, AA091457_P3, AA091457_P4 and AA091457_P5, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_39 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T6, AA091457_T7, AA091457_T8 and AA091457_T9. Table 4202 below describes the starting and ending position of this segment on each transcript.

Table 4202 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AAO91457_P1, AA091457_P2, AA091457_P3, AA091457_P4 and AA091457 P5.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster AA091457_node_2 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14, AA091457_T15 and AA091457_T16. Table 4203 below describes the starting and ending position of this segment on each transcript.

Table 4203 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457_P5, AA091457_P8 and AA091457_P6. Segment cluster AA091457_node_l 1 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AA091457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457JN2, AA091457_T14 and AA091457_T15. Table 4204 below describes the starting and ending position of this segment on each transcript.

Table 4204 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457_P5 and AA091457_P8. This segment can also be found in the following ρrotein(s): AAO91457_P1, AA091457_P2, AA091457_P3, AA091457_P4 and AA091457JP6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_13 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AA091457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4205 below describes the starting and ending position of this segment on each transcript. Table 4205 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AA091457_P5 and AA091457_P8. This segment can also be found in the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4 and AA091457_P6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_20 according to the present invention can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4206 below describes the starting and ending position of this segment on each transcript.

Table 4206 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457_P8. This segment can also be found in the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457JP4, AA091457_P5 and AA091457_P6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_22 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4207 below describes the starting and ending position of this segment on each transcript.

Table 4207 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AA091457_P8. This segment can also be found in the following protein(s): AAO91457JP1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457_P5 and AA091457JP6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_24 according to the present invention is supported by

25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AA091457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4208 below describes the starting and ending position of this segment on each transcript.

Table 4208 - Segment location on transcripts

This segment can be found in the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457_P5, AA091457_P8 and AA091457_P6.

Segment cluster AA091457_node_25 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AA091457JN, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4209 below describes the starting and ending position of this segment on each transcript. Table 4209 - Segment location on transcripts

This segment can be found in the following protein(s): AAO91457_P1, AA091457_P2, AA091457_P4, AA091457_P5, AA091457_P8 and AA091457_P6.

Segment cluster AA091457_node_27 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AA091457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T9, AA091457_T12 and AA091457_T14. Table 4210 below describes the starting and ending position of this segment on each transcript.

Table 4210 - Segment location on transcripts

This segment can be found in the following protein(s)- AAO91457_P1, AA091457_P2, AA091457JP3, AA091457_P5 and AA091457_P8.

Segment cluster AA091457_node_28 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AA091457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4211 below describes the starting and ending position of this segment on each transcript.

Table 4211 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): AA091457JP8. This segment can also be found in the following protein(s): AAO91457_P1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457_P5 and AA091457_P6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_30 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T5, AA091457_T6, AA091457_T7, AA091457_T8, AA091457_T9, AA091457_T12, AA091457_T14 and AA091457_T15. Table 4212 below describes the starting and ending position of this segment on each transcript.

Table 4212 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AA091457_P8. This segment can also be found in the following protein(s): AA091457JP1, AA091457_P2, AA091457_P3, AA091457_P4, AA091457_P5 and AA091457_P6, since it is in the coding region for the corresponding transcript.

Segment cluster AA091457_node_36 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): AA091457_T0, AAO91457_T1, AA091457_T2, AA091457_T4, AA091457_T6, AA091457_T7, AA091457_T8 and AA091457_T9. Table 4213 below describes the starting and ending position of this segment on each transcript.

Table 4213 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): AAO91457_P1, AA091457_P2, AA091457_P3, AA091457_P4 and AA091457_P5.

Segment cluster AA091457_node_37 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA091457_T0, AA091457_T1, AA091457_T2, AA091457_T4, AA091457_T6, AA091457_T7, AA091457_T8 and AA091457_T9. Table 4214 below describes the starting and ending position of this segment on each transcript.

Table 4214 - Segment location on transcripts

This segment can be found in a non- coding region of trans cript(s) that are related to the following protein(s): AAO91457_P1, AA091457_P2, AA091457_P3, AA091457_P4 and AA091457 P5. DESCRIPTION FOR CLUSTER AA722065

Cluster AA722065 features 4 transcript(s) and 4 segment(s) of interest, the names for which are given in Tables 4215 and 4216, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4217.

Table 4215 - Transcripts of interest

Transcript Name

AA722065 TO

AA722065 Tl

AA722065 T2

AA722065 T3

Table 4216 - Segments of interest

Segment Name

AA722065 node 0

AA722065 node 5

AA722065 node 7

AA722065 node 8

Table 4217 - Proteins of interest

The heart-selective diagnostic marker prediction engine provided the following results with regard to cluster AA722065. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y-axis of Figure 106 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 106, concerning the number of heart- specific clones in libraries/sequences. This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 41.7; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 2.2; and fisher exact test P-values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 4.70E-03.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 41.7, which clearly supports specific expression in heart tissue.

As noted above, cluster AA722065 features 4 segment(s), which were listed in Table 4216 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster AA722065_node_0 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA722065_T2 and AA722065_T3. Table 4218 below describes the starting and ending position of this segment on each transcript.

Table 4218 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster AA722065_node_5 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA722065_T3. Table 4219 below describes the starting and ending position of this segment on each transcript.

Table 4219 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster AA722065_node_7 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AA722065JTO and AA722065_T1. Table 4220 below describes the starting and ending position of this segment on each transcript.

Table 4220 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster AA722065_node_8 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): AA722065_T0, AA722O65_T1, AA722065_T2 and AA722065_T3. Table 4221 below describes the starting and ending position of this segment on each transcript.

Table 4221 - Segment location on transcripts

The previoυsly - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER AL600896

Cluster AL600896 features 1 transcript(s) and 1 segment(s) of interest, the names for which are given in Tables 4222 and 4223, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4224.

Table 4222 - Transcripts of interest

Transcript Name

AL600896 TO

Table 4223 - Segments of interest

Segment Name

AL600896 node 0

Table 4224 - Proteins of interest

The heart-selective diagnostic marker prediction engine provided the following results with regard to cluster AL600896. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y-axis of Figure 107 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 107, concerning the number of heart- specific clones in libraries/sequences.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 85.3; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 55.5; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 3.50E-05.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 85.3, which clearly supports specific expression in heart tissue.

As noted above, cluster AL600896 features 1 segment(s), which were listed in Table 4223 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster AL600896_node_0 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): AL600896_T0. Table 4225 below describes the starting and ending position of this segment on each transcript.

Table 4225 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER F09066

Cluster F09066 features 23 transcript(s) and 72 segment(s) of interest, the names for which are given in Tables 4226 and 4227, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4228. Table 4226 - Transcripts of interest

Transcrip t Name

F09066 Tl

F09066 T2

F09066 T5

F09066 T8

F09066 T9

F09066 TlO

F09066 TI l

F09066 T12

F09066 T13

F09066 T14

F09066 T15 F09066 T17

F09066 T18

F09066 T20

F09066 T24

F09066 T26

F09066 T27

F09066 T29

F09066 T36

F09066 T39

F09066 T41

F09066 T42

F09066 T43

Table4227-Segmentsofinterest

Table 4228 - Proteins of interest

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 4229.

Table 4229 - Oligonucleotides related to this cluster

As noted above, cluster F09066 features 72 segment(s), which were listed in Table 4227 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster F09066_node_0 according to the present invention is supported by 1 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): FO9O66_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066 T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4230 below describes the starting and ending position of this segment on each transcript.

Table 4230 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8,F09066_P9,F09066JP10,F09066_P12,F09066J>13,F09066_P18,F09066_P19, F09066 P35,F09066 P27andF09066 P30.

Segment cluster F09066_node_6 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4231 below describes the starting and ending position of this segment on each transcript.

Table 4231 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066JP6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066JP18, F09066_P19, F09066_P35, F09066_P27 and F09066_P30.

Segment cluster F09066_node_21 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4232 below describes the starting and ending position of this segment on each transcript.

Table 4232 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066JP6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066JP13, F09066_P18, F09066_P19, F09066_P35 and F09066_P27. This segment can also be found in the following protein(s): F09066_P30, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_31 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4233 below describes the starting and ending position of this segment on each transcript.

Table 4233 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P35 and F09066_P27. This segment can also be found in the following protein(s): F09066_P30, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_32 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066JF2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4234 below describes the starting and ending position of this segment on each transcript.

Table 4234 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066JP8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P35, F09066_P27 and F09066_P30.

Segment cluster F09066_node_38 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T43. Table 4235 below describes the starting and ending position of this segment on each transcript.

Table 4235 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P30.

Segment cluster F09066_node_41 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T42. Table 4236 below describes the starting and ending position of this segment on each transcript. Table 4236 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P30.

Segment cluster F09066_node_46 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27,

F09066_T36, F09066_T39 and F09066_T41. Table 4237 below describes the starting and ending position of this segment on each transcript.

Table 4237 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066JP9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066JP27 and F09066_P30. This segment can also be found in the following protein(s): F09066_P8, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_47 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T41. Table 4238 below describes the starting and ending position of this segment on each transcript.

Table 4238 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P30.

Segment cluster F09066_node_51 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36 and F09066_T39. Table 4239 below describes the starting and ending position of this segment on each transcript. Table 4239 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P9, F09066 P10 and F09066_P30. This segment can also be found in the following protein(s): F09066_P2, F09066J^>8, F09066_P12, F09066_P13, F09066_P18, F09066JP19, F09066_P35 and F09066_P27, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_57 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T10, F09066_T20 and F09066_T39. Table 4240 below describes the starting and ending position of this segment on each transcript.

Table 4240 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3 and F09066_P30. This segment can also be found in the following protein(s): F09066_P7, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_58 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): FO9O66_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36 and F09066_T39. Table 4241 below describes the starting and ending position of this segment on each transcript.

Table 4241 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066JP3, F09066JP5, F09066_P6, F09066 P9, F09066JP10 and F09066_P30. This segment can also be found in the following protein(s): F09066_P2, F09066_P7, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P35 and F09066_P27, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_60 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T36 and F09066_T39. Table 4242 below describes the starting and ending position of this segment on each transcript.

Table 4242 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P30. This segment can also be found in the following protein(s): F09066_P27, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_63 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4243 below describes the starting and ending position of this segment on each transcript.

Table 4243 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066_P6, F09066_P9 and F09066_P10. This segment can also be found in the following protein(s): F09066_P2, F09066_P7, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_69 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4244 below describes the starting and ending position of this segment on each transcript.

Table 4244 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5 and F09066_P6. This segment can also be found in the following protein(s): F09066_P2, F09066_P7, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_70 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T2, F09066_T9, F09066_T15 and F09066_T20. Table 4245 below describes the starting and ending position of this segment on each transcript.

Table 4245 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P5 and F09066_P6. This segment can also be found in the following protein(s): F09066_P3, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_74 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): FO9O66_T1 , F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066JH5, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4246 below describes the starting and ending position of this segment on each transcript. Table 4246 - Segment location on transcripts

This segment can be found in both coding and non-codmg regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P5, F09066_P6 and F09066_P9. This segment can also be found in the following protein(s): F09066J^»2, F09066JP3, F09066_P7, F09066_P8, F09066_P10, F09066_P12, F09066_P13, F09066JP18, F09066_P19 and F09066_P35, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_75 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T5 and F09066_T9. Table 4247 below describes the starting and ending position of this segment on each transcript.

Table 4247 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P5.

Segment cluster F09066_node_78 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T8 and F09066_T15. Table 4248 below describes the starting and ending position of this segment on each transcript.

Table 4248 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P6.

Segment cluster F09066_node_84 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066JN, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4249 below describes the starting and ending position of this segment on each transcript.

Table 4249 - Segment location on transcripts

This segment can be found in the following protein(s): F09066JP2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066JP8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35.

Segment cluster F09066_node_86 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066JN 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4250 below describes the starting and ending position of this segment on each transcript.

Table 4250 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3,

F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066J^>12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35.

Segment cluster F09066_node_95 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10₅ F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066JN8, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4251 below describes the starting and ending position of this segment on each transcript.

Table 4251 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 andF09066_P35.

Segment cluster F09066_node_98 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tll, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4252 below describes the starting and ending position of this segment on each transcript.

Table 4252 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P12 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P13, F09066_P18 and F09066_P19, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_100 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4253 below describes the starting and ending position of this segment on each transcript.

Table 4253 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066 P12 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P13, F09066_P18 and F09066_P19, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_102 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20 and F09066_T24. Table 4254 below describes the starting and ending position of this segment on each transcript. Table 4254 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9,

F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_103 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl , F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, FO9O66_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4255 below describes the starting and ending position of this segment on each transcript. Table 4255 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066JP6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P13, F09066_P18 and F09066_P19, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_105 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066 T29. Table 4256 below describes the starting and ending position of this segment on each transcript.

Table 4256 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066JP12, F09066_P18, F09066_P19 and F09066 P35. This segment can also be found in the following protein(s): F09066_P2, F09066JP3, F09066_P5, F09066_P6, F09066_P7, F09066JP8, F09066_P9, F09066JP10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_106 according to the present invention is supported by 139 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4257 below describes the starting and ending position of this segment on each transcript.

Table 4257 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066JP8, F09066JP9, F09066JP10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_l 17 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): FO9O66_T1, F09066 T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4258 below describes the starting and ending position of this segment on each transcript.

Table 4258 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066JP12, F09066_P18, F09066JP19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster F09066_node_8 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4259 below describes the starting and ending position of this segment on each transcript.

Table 4259 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066 P35, F09066 P27 and F09066_P30.

Segment cluster F09066_node_9 according to the present invention is supported by 15 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tll, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4260 below describes the starting and ending position of this segment on each transcript. Table 4260 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066JP18, F09066_P19, F09066_P35 and F09066_P27. This segment can also be found in the following protein(s): F09066_P30, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_13 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tll, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4261 below describes the starting and ending position of this segment on each transcript.

Table 4261 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066JP12, F09066_P13, F09066_P18, F09066_P19, F09066_P35 and F09066_P27. This segment can also be found in the following protein(s): F09066_P30, since it is in the coding region for the corresponding transcript. Segment cluster F09066_node_23 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4262 below describes the starting and ending position of this segment on each transcript.

Table 4262 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P35 and F09066JP27. This segment can also be found in the following protein(s): F09066_P30, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_26 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): FO9O66_T1, F09066 T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4263 below describes the starting and ending position of this segment on each transcript.

Table 4263 - Segment location on transcripts

F09066 T43 757 832

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066J^>3, F09066_P5, F09066_P6, F09066J^>7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066 P35 and F09066 P27. This segment can also be found in the following protein(s): F09066JP30, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_30 according to the present invention can be found in the following transcript(s): F09066_T1 , F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tll, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4264 below describes the starting and ending position of this segment on each transcript. Table 4264 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066JP5, F09066_P6, F09066JP7, F09066JP8, F09066_P9, F09066_P10, F09066_P12, F09066JP13, F09066_P18, F09066_P19, F09066_P35 and F09066_P27. This segment can also be found in the following protein(s): F09066_P30, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_33 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): FO9O66_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4265 below describes the starting and ending position of this segment on each transcript.

Table 4265 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066JP3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066JP9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066JP19, F09066_P35, F09066JP27 and F09066_P30.

Segment cluster F09066_node_35 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4266 below describes the starting and ending position of this segment on each transcript. Table 4266 - Segment location on transcripts

005/002438

2428

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): F09066JP2, F09066JP3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066JP35, F09066JP27 and F09066_P30.

Segment cluster F09066_node_36 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4267 below describes the starting and ending position of this segment on each transcript. Table 4267 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066JP6, F09066_P7, F09066_P9, F09066J^>10, F09066J^>12, F09066_P13, F09066JP18, F09066_P19, F09066_P27 and F09066_P30. This segment can also be found in the following protein(s): F09066_P8 and F09066_P35, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_37 according to the present invention can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41, F09066_T42 and F09066_T43. Table 4268 below describes the starting and ending position of this segment on each transcript. Table 4268 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P27 and F09066_P30. This segment can also be found in the following protein(s): F09066_P8 and F09066_P35, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_40 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tll, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36, F09066_T39, F09066_T41 and F09066_T42. Table 4269 below describes the starting and ending position of this segment on each transcript.

Table 4269 - Segment location on transcripts 2438

2431

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P9, F09066JP10, F09066_P12, F09066JP13, F09066_P18, F09066_P19, F09066_P27 and F09066_P30. This segment can also be found in the following protein(s): F09066_P8 and F09066_P35, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_49 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, 38

2432

F09066_T29, F09066_T36 and F09066_T39. Table 4270 below describes the starting and ending position of this segment on each transcript.

Table 4270 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P9, F09066_P10 and F09066_P30. This segment can also be found in the following protein(s): F09066_P2, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P35 and F09066_P27, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_53 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066J9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36 and F09066_T39. Table 4271 below describes the starting and ending position of this segment on each transcript.

Table 4271 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P9, F09066_P10 and F09066_P30. This segment can also be found in the following protein(s): F09066_P2, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066JP19, F09066_P35 and F09066JP27, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_55 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066JT11, F09066_T12, F09066_T13, F09066_T14, 2438

2434

F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36 and F09066_T39. Table 4272 below describes the starting and ending position of this segment on each transcript.

Table 4272 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P9, F09066JP10 and F09066_P30. This segment can also be found in the following protein(s): F09066_P2, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P35 and F09066_P27, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_56 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36 and F09066_T39. Table 4273 below describes the starting and ending position of this segment on each transcript.

Table 4273 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066JP9, F09066_P10 and F09066_P30. This segment can also be found in the following protein(s): F09066_P2, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P35 and F09066JP27, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_59 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, FO9O66_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27, F09066_T29, F09066_T36 and F09066_T39. Table 4274 below describes the starting and ending position of this segment on each transcript.

Table 4274 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066_P6, F09066JP9, F09066_P10 and F09066_JP30. This segment can also be found in the following protein(s): F09066_P2, F09066JP7, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066_P19, F09066_P35 and F09066_P27, since it is in the coding region for the corresponding transcript. Segment cluster F09066_node_66 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4275 below describes the starting and ending position of this segment on each transcript.

Table 4275 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066JP6 and F09066_P9. This segment can also be found in the following protein(s): F09066_P2, F09066_P7, F09066JP8, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35, since it is in the coding region for the corresponding transcript. Segment cluster F09066_node_67 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4276 below describes the starting and ending position of this segment on each transcript.

Table 4276 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P3, F09066_P5, F09066_P6 and F09066_P9. This segment can also be found in the following protein(s): F09066_P2, F09066_P7, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066JP19 and F09066_P35, since it is in the coding region for the corresponding transcript. Segment cluster F09066_node_71 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4277 below describes the starting and ending position of this segment on each transcript.

Table 4277 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P5, F09066_P6 and F09066_P9. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P7, F09066_P8, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35, since it is in the coding region for the corresponding transcript. Segment cluster F09066_node_72 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066 T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4278 below describes the starting and ending position of this segment on each transcript.

Table 4278 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P5, F09066_P6 and F09066_P9. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P7, F09066_P8, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35, since it is in the coding region for the corresponding transcript. Segment cluster F09066_node_76 according to the present invention can be found in the following transcript(s): F09066_T5 and F09066_T9. Table 4279 below describes the starting and ending position of this segment on each transcript.

Table 4279 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P5.

Segment cluster F09066_node_77 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4280 below describes the starting and ending position of this segment on each transcript. Table 4280 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcπpt(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P6. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35, since it is in the coding region for the corresponding transcript.

Segment cluster F09066__node_79 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4281 below describes the starting and ending position of this segment on each transcript.

Table 4281 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066 P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35.

Segment cluster F09066_node_80 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4282 below describes the starting and ending position of this segment on each transcript.

Table 4282 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066JP6, F09066JP7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066JP13, F09066_P18, F09066_P19 and F09066_P35.

Segment cluster F09066_node_81 according to the present invention can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4283 below describes the starting and ending position of this segment on each transcript.

Table 4283 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35. Segment cluster F09066_node_83 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4284 below describes the starting and ending position of this segment on each transcript.

Table 4284 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3,

F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066JP19 and F09066_P35.

Segment cluster F09066_node_88 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4285 below describes the starting and ending position of this segment on each transcript.

Table 4285 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35.

Segment cluster F09066_node_89 according to the present invention can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T20, F09066_T24, F09066_T26 and F09066_T29. Table 4286 below describes the starting and ending position of this segment on each transcript.

Table 4286 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066 P18 and F09066 P35.

Segment cluster F09066_node_90 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T20, F09066_T24 and F09066_T26. Table 4287 below describes the starting and ending position of this segment on each transcript.

Table 4287 - Segment location on transcripts

This segment can be found in the following protein(s): F09066 P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P18.

Segment cluster F09066_node_91 according to the present invention can be found in the following transcript(s): FO9O66_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T18, F09066_T20, F09066_T24, F09066_T26 and F09066_T27. Table 4288 below describes the starting and ending position of this segment on each transcript.

Table 4288 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P13, F09066 P18 and F09066 P19.

Segment cluster F09066_node_92 according to the present invention can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4289 below describes the starting and ending position of this segment on each transcript.

Table 4289 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35. Segment cluster F09066_node_93 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066JN7, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4290 below describes the starting and ending position of this segment on each transcript.

Table 4290 - Segment location on transcripts

This segment can be found in the following protein(s): F09066_P2, F09066_P3,

F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10, F09066_P12, F09066_P13, F09066_P18, F09066_P19 and F09066_P35.

Segment cluster F09066_node_104 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4291 below describes the starting and ending position of this segment on each transcript.

Table 4291 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066JP8, F09066JP9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_107 according to the present invention can be found in the following transcript(s): F09066_T1 , F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4292 below describes the starting and ending position of this segment on each transcript.

Table 4292 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of trans cript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_108 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_129. Table 4293 below describes the starting and ending position of this segment on each transcript.

Table 4293 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_109 according to the present invention can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, FO9O66_T11, F09066_T12, F09066_T13, F09066JN4, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4294 below describes the starting and ending position of this segment on each transcript.

Table 4294 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_l 10 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066JU7, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4295 below describes the starting and ending position of this segment on each transcript.

Table 4295 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066 P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066JP10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_l 11 according to the present invention is supported by 143 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4296 below describes the starting and ending position of this segment on each transcript.

Table 4296 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_l 12 according to the present invention is supported by 151 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_T1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4297 below describes the starting and ending position of this segment on each transcript.

Table 4297 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_l 13 according to the present invention can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4298 below describes the starting and ending position of this segment on each transcript.

Table 4298 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_l 14 according to the present invention is supported by 156 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, FO9O66_T11, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4299 below describes the starting and ending position of this segment on each transcript.

Table 4299 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_l 15 according to the present invention can be found in the following transcript(s): F09066_Tl, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl l, F09066_T12, F09066_T13, F09066_T14, F09066_T15, F09066_T17, F09066_T18, F09066_T20, F09066_T24, F09066_T26, F09066_T27 and F09066_T29. Table 4300 below describes the starting and ending position of this segment on each transcript.

Table 4300 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066_P5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

Segment cluster F09066_node_l 16 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): F09066JT1, F09066_T2, F09066_T5, F09066_T8, F09066_T9, F09066_T10, F09066_Tl 1, F09066_T12, F09066_T13, F09066_T14, F09066JT15, F09066_T17, F09066_T18, F09066_T20, F09066JT24, F09066_T26, F09066_T27 and F09066_T29. Table 4301 below describes the starting and ending position of this segment on each transcript.

Table 4301 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): F09066_P12, F09066_P18, F09066_P19 and F09066_P35. This segment can also be found in the following protein(s): F09066_P2, F09066_P3, F09066JP5, F09066_P6, F09066_P7, F09066_P8, F09066_P9, F09066_P10 and F09066_P13, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER H88495

Cluster H88495 features 4 transcript(s) and 22 segment(s) of interest, the names for which are given in Tables 4302 and 4303, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4304. Table 4302 - Transcripts of interest

Transcript Name

H88495 PEA 3 T4

H88495 PEA 3 T5

H88495 PEA 3 T6

H88495 PEA 3 T7

Table 4303 - Segments of interest

Segment Name _*

H88495 PEA 3 node 0

H88495 PEA 3 node 1

H88495 PEA 3 node 4

H88495 PEA 3 node 9

H88495 PEA 3 node 13

H88495 PEA 3 node 19

H88495 PEA 3 node 21

H88495 PEA 3 node 26

H88495 PEA 3 node 2

H88495 PEA 3 node 5

H88495 PEA 3 node 6

H88495 PEA 3 node 7

H88495 PEA 3 node 8

H88495 PEA 3 node 10

H88495 PEA 3 node 11

H88495 PEA 3 node _12

H88495 PEA 3 node 14

H88495 PEA 3 node 16

H88495 PEA 3 node 18

H88495 PEA 3 node 20

H88495 PEA 3 node 23

H88495 PEA 3 node 24

Table 4304 - Proteins of interest

These sequences are variants of the known protein Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor (SwissProt accession identifier SRCH_HUMAN), referred to herein as the previously known protein.

Protein Sarcoplasmic reticulum histidine-rich calcium- binding protein precursor is known or believed to have the following function(s): May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. The sequence for protein Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor is given at the end of the application, as "Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4305. Table 4305 - Amino acid mutations for Known Protein

Protein Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor localization is believed to be Sarcoplasmic reticulum lumen.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: muscle contraction, which are annotation(s) related to Biological Process; and calcium binding, which are annotation(s) related to Molecular Function. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster H88495. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 108 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 108, concerning the number of heart- specific clones in libraries/sequences; as well as with regard to the histogram in Figure 109, concerning the actual expression of oligonucleotides in various tissues, including heart.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 13.7; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 2.3; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be l.90E-06.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 13.7, which clearly supports specific expression in heart tissue.

As noted above, cluster H88495 features 22 segment(s), which were listed in Table 4303 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster H88495_PEA_3_node_0 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495JPEA_3_T4, H88495_PEA_3_T5, H88495 J^>EA_3_T6 and H88495_PEA_3_T7. Table 4306 below describes the starting and ending position of this segment on each transcript.

Table 4306 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H88495_PEA_3_P15 and H88495_PEA_3_P16.

Segment cluster H88495_PEA_3_node_l according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4307 below describes the starting and ending position of this segment on each transcript.

Table 4307 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3JP15 and H88495JPEA_3_P16.

Segment cluster H88495_PEA_3_node_4 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4308 below describes the starting and ending position of this segment on each transcript.

Table 4308 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495_PEA_3_P16.

Segment cluster H88495_PEA_3_node_9 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4309 below describes the starting and ending position of this segment on each transcript.

Table 4309 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495 PEA 3 P16.

Segment cluster H88495_PEA_3_node_13 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4310 below describes the starting and ending position of this segment on each transcript.

Table 4310 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3JP15 and H88495 PEA 3 P16.

Segment cluster H88495_PEA_3_node_19 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4 and H88495_PEA_3_T7. Table 4311 below describes the starting and ending position of this segment on each transcript.

Table 4311 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15.

Segment cluster H88495_PEA_3_node_21 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4312 below describes the starting and ending position of this segment on each transcript.

Table 4312 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H88495_PEA_3_P15. This segment can also be found in the following protein(s): H88495_PEA_3_P16, since it is in the coding region for the corresponding transcript.

Segment cluster H88495_PEA_3_node_26 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4313 below describes the starting and ending position of this segment on each transcript.

Table 4313 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H88495_PEA_3_P15 and H88495_PEA_3_P16.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster H88495_PEA_3_node_2 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495JPEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4314 below describes the starting and ending position of this segment on each transcript.

Table 4314 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495_PEA_ 3_P16.

Segment cluster H88495_PEA_3_node_5 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4315 below describes the starting and ending position of this segment on each transcript.

Table 4315 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495 PEA 3 P16.

Segment cluster H88495_PEA_3_node_6 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4316 below describes the starting and ending position of this segment on each transcript.

Table 4316 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495 PEA 3 Pl 6.

Segment cluster H88495_PEA_3_node_7 according to the present invention can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4317 below describes the starting and ending position of this segment on each transcript.

Table 4317 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495 PEA 3 Pl 6.

Segment cluster H88495_PEA_3_node_8 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4318 below describes the starting and ending position of this segment on each transcript. Table 4318 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495_PEA_3_P16.

Segment cluster H88495_PEA__3_node_10 according to the present invention can be found in the following transcripts): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4319 below describes the starting and ending position of this segment on each transcript.

Table 4319 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495 PEA 3 P 16.

Segment cluster H88495_PEA_3_node_l 1 according to the present invention can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4320 below describes the starting and ending position of this segment on each transcript.

Table 4320 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3JP15 and H88495_PEA_3_P16.

Segment cluster H88495_PEA_3_node_12 according to the present invention can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4321 below describes the starting and ending position of this segment on each transcript.

Table 4321 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495 PEA 3 Pl 6.

Segment cluster H88495_PEA_3_node_14 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEA_3_T7. Table 4322 below describes the starting and ending position of this segment on each transcript.

Table 4322 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495_PEA_3_P16.

Segment cluster H88495_PEA_3_node_16 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495_PEAJ3_T7. Table 4323 below describes the starting and ending position of this segment on each transcript.

Table 4323 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495 PEA 3 P16.

Segment cluster H88495_PEA_3_node_18 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495JPEA_3_T6 and H88495JPEA_3__T7. Table 4324 below describes the starting and ending position of this segment on each transcript.

Table 4324 - Segment location on transcripts

This segment can be found in the following protein(s): H88495_PEA_3_P15 and H88495 PEA 3 P 16. Segment cluster H88495_PEA_3_node_20 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495J?EA_3_T7. Table 4325 below describes the starting and ending position of this segment on each transcript.

Table 4325 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H88495_PEA_3_P15. This segment can also be found in the following protein(s): H88495_PEA_3_P16, since it is in the coding region for the corresponding transcript.

Segment cluster H88495_PEA_3_node_23 according to the present invention can be found in the following transcript(s): H88495_PEA_3_T4. Table 4326 below describes the starting and ending position of this segment on each transcript.

Table 4326 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H88495_PEA_3_P15.

Segment cluster H88495_PEA_3_node_24 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H88495_PEA_3_T4, H88495_PEA_3_T5, H88495_PEA_3_T6 and H88495JPEA_3_T7. Table 4327 below describes the starting and ending position of this segment on each transcript.

Table 4327 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H88495_PEA_3_P15 and H88495_PEA_3_P16.

DESCRIPTION FOR CLUSTER HSACMHCP

Cluster HSACMHCP features 1 transcript(s) and 55 segment(s) of interest, the names for which are given in Tables 4328 and 4329, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4330.

Table 4328 - Transcripts of interest

Transcript Name

HSACMHCP PEA 1 T6

Table 4329 - Segments of interest

Segment Name

HSACMHCP PEA 1 node 20

HSACMHCP PEA 1 node 22

HSACMHCP PEA 1 node 25

HSACMHCP PEA 1 node 43

HSACMHCP PEA 1 node 45 HSACMHCP PEA 1 node 49

HSACMHCP PEA 1 node 57

HSACMHCP PEA 1 node 59

HSACMHCP PEA 1 node 61

HSACMHCP PEA 1 node 63

HSACMHCP PEA 1 node 65

HSACMHCP PEA 1 node 67

HSACMHCP PEA 1 node 71

HSACMHCP PEA 1 node 87

HSACMHCP PEA 1 node 89

HSACMHCP PEA 1 node 96

HSACMHCP PEA 1 node 97

HSACMHCP PEA 1 node 100

HSACMHCP PEA 1 node 106

HSACMHCP PEA 1 node 107

HSACMHCP PEA 1 node 111

HSACMHCP PEA 1 node 113

HSACMHCP PEA 1 node 16

HSACMHCP PEA 1 node 18

HSACMHCP PEA 1 node 23

HSACMHCP PEA 1 node 27

HSACMHCP PEA 1 node 29

HSACMHCP PEA 1 node 31

HSACMHCP PEA 1 node 33

HSACMHCP PEA 1 node 35

HSACMHCP_ _PEA_ _1_ node _37

HSACMHCP PEA 1 node 39

HSACMHCP PEA 1 node 40

HSACMHCP PEA 1 node 51

HSACMHCP PEA 1 node 53

HSACMHCP PEA 1 node 55

HSACMHCP PEA 1 node 69

HSACMHCP PEA 1 node 72

HSACMHCP PEA 1 node 73

HSACMHCP PEA 1 node 74

HSACMHCP PEA 1 node 77

HSACMHCP PEA 1 node 78

HSACMHCP PEA 1 node 80

HSACMHCP PEA 1 node 82

HSACMHCP PEA 1 node 83

HSACMHCP PEA 1 node 84

HSACMHCP PEA 1 node 85

HSACMHCP PEA 1 node 91

HSACMHCP PEA 1 node 92 HSACMHCP PEA 1 node 93

HSACMHCP PEA 1 node 95

HSACMHCP PEA 1 node 98

HSACMHCP PEA 1 node 103

HSACMHCP PEA 1 node 104

HSACMHCP PEA 1 node 109

Table 4330 - Proteins of interest

These sequences are variants of the known protein Myosin heavy chain, cardiac muscle alpha isoform (SwissProt accession identifier MYH6_HUMAN; known also according to the synonyms MyHC-alpha), referred to herein as the previously known protein.

Protein Myosin heavy chain, cardiac muscle alpha isoform is known or believed to have the following function(s): Muscle contraction. The sequence for protein Myosin heavy chain, cardiac muscle alpha isoform is given at the end of the application, as "Myosin heavy chain, cardiac muscle alpha isoform amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4331.

Table 4331 - Amino acid mutations for Known Protein

Protein Myosin heavy chain, cardiac muscle alpha isoform localization is believed to be Thick filaments of the myofibrils.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: muscle contraction; striated muscle contraction; muscle development, which are annotation(s) related to Biological Process; microfilament motor; actin binding; calmodulin binding; ATP binding, which are annotation(s) related to Molecular Function; and muscle myosin; muscle thick filament; myosin, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

The heart-selective diagnostic marker prediction engine provided the following results with regard to cluster HSACMHCP. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y-axis of Figure 110 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 110, concerning the number of heart- specific clones in libraries/sequences; as well as with regard to the histogram in Figures 111-112 concerning the actual expression of oligonucleotides in various tissues, including heart.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 24; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 92.5; and fisher exact test P-values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 3.20E-47.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 24, which clearly supports specific expression in heart tissue.

As noted above, cluster HSACMHCP features 55 segment(s), which were listed in Table 4329 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSACMHCP_PEA_l_node_20 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_ 1_T6. Table 4332 below describes the starting and ending position of this segment on each transcript. Table 4332 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_22 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4333 below describes the starting and ending position of this segment on each transcript.

Table 4333 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_25 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4334 below describes the starting and ending position of this segment on each transcript.

Table 4334 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCPJPEA_l_node_43 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4335 below describes the starting and ending position of this segment on each transcript. Table 4335 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_45 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4336 below describes the starting and ending position of this segment on each transcript.

Table 4336 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_49 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4337 below describes the starting and ending position of this segment on each transcript.

Table 4337 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_57 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4338 below describes the starting and ending position of this segment on each transcript. Table 4338 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_59 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4339 below describes the starting and ending position of this segment on each transcript.

Table 4339 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_61 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4340 below describes the starting and ending position of this segment on each transcript.

Table 4340 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_63 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4341 below describes the starting and ending position of this segment on each transcript. Table 4341 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_ l_node_65 according to the present invention is supported by 7 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4342 below describes the starting and ending position of this segment on each transcript.

Table 4342 ~ Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_67 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4343 below describes the starting and ending position of this segment on each transcript.

Table 4343 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_71 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4344 below describes the starting and ending position of this segment on each transcript. Table 4344 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_87 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4345 below describes the starting and ending position of this segment on each transcript.

Table 4345 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_89 according to the present invention is supported by 15 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4346 below describes the starting and ending position of this segment on each transcript.

Table 4346 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_96 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4347 below describes the starting and ending position of this segment on each transcript. Table 4347 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_97 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4348 below describes the starting and ending position of this segment on each transcript.

Table 4348 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_100 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4349 below describes the starting and ending position of this segment on each transcript.

Table 4349 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_106 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4350 below describes the starting and ending position of this segment on each transcript. Table 4350 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_l 07 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4351 below describes the starting and ending position of this segment on each transcript.

Table 4351 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_l 11 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4352 below describes the starting and ending position of this segment on each transcript.

Table 4352 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_l 13 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4353 below describes the starting and ending position of this segment on each transcript.

Table 4353 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSACMHCP_PEA_1_P2.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSACMHCP_PEA_l_node_16 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4354 below describes the starting and ending position of this segment on each transcript.

Table 4354 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_ l_node_18 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4355 below describes the starting and ending position of this segment on each transcript.

Table 4355 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_23 according to the present invention can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4356 below describes the starting and ending position of this segment on each transcript.

Table 4356 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1 JP2.

Segment cluster HSACMHCP_PEA_l_node_27 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4357 below describes the starting and ending position of this segment on each transcript.

Table 4357 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_29 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4358 below describes the starting and ending position of this segment on each transcript.

Table 4358 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_31 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4359 below describes the starting and ending position of this segment on each transcript.

Table 4359 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_33 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4360 below describes the starting and ending position of this segment on each transcript.

Table 4360 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP JPEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_35 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4361 below describes the starting and ending position of this segment on each transcript.

Table 4361 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCPJPEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_37 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4362 below describes the starting and ending position of this segment on each transcript.

Table 4362 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_J39 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4363 below describes the starting and ending position of this segment on each transcript.

Table 4363 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCPJPEA_l_node_40 according to the present invention can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4364 below describes the starting and ending position of this segment on each transcript.

Table 4364 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_ l_node_51 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4365 below describes the starting and ending position of this segment on each transcript.

Table 4365 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCPJPEA_l_node_53 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4366 below describes the starting and ending position of this segment on each transcript.

Table 4366 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_55 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4367 below describes the starting and ending position of this segment on each transcript.

Table 4367 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_69 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4368 below describes the starting and ending position of this segment on each transcript.

Table 4368 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_72 according to the present invention can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4369 below describes the starting and ending position of this segment on each transcript. Table 4369 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_1 jtiode_73 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4370 below describes the starting and ending position of this segment on each transcript.

Table 4370 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_74 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4371 below describes the starting and ending position of this segment on each transcript.

Table 4371 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCPJPEA 1 P2.

Segment cluster HSACMHCP_PEA_l_node_77 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcripts): HSACMHCP_PEA_1_T6. Table 4372 below describes the starting and ending position of this segment on each transcript.

Table 4372 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_78 according to the present invention can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4373 below describes the starting and ending position of this segment on each transcript.

Table 4373 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_80 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4374 below describes the starting and ending position of this segment on each transcript.

Table 4374 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_82 according to the present invention can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4375 below describes the starting and ending position of this segment on each transcript. Table 4375 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_83 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4376 below describes the starting and ending position of this segment on each transcript.

Table 4376 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_1 jnode_84 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4377 below describes the starting and ending position of this segment on each transcript.

Table 4377 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_ l_node_85 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4378 below describes the starting and ending position of this segment on each transcript.

Table 4378 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HS ACMHCP-PE A_l_node_91 according to the present invention is supported by 12 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4379 below describes the starting and ending position of this segment on each transcript.

Table 4379 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP PEA 1JP2.

Segment cluster HSACMHCP_PEA_l_node_92 according to the present invention can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4380 below describes the starting and ending position of this segment on each transcript.

Table 4380 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1JP2.

Segment cluster HSACMHCP_PEA_l_node_93 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4381 below describes the starting and ending position of this segment on each transcript. Table 4381 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP PEAJJP2.

Segment cluster HSACMHCP_PEA_l_node_95 according to the present invention can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4382 below describes the starting and ending position of this segment on each transcript.

Table 4382 - Segment location on transcripts

HSACMHCP PEA 1 T6 4728 4742

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_98 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP JPEA_1_T6. Table 4383 below describes the starting and ending position of this segment on each transcript.

Table 4383 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_103 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4384 below describes the starting and ending position of this segment on each transcript.

Table 4384 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_104 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4385 below describes the starting and ending position of this segment on each transcript.

Table 4385 - Segment location on transcripts

This segment can be found in the following protein(s): HSACMHCP_PEA_1_P2.

Segment cluster HSACMHCP_PEA_l_node_109 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSACMHCP_PEA_1_T6. Table 4386 below describes the starting and ending position of this segment on each transcript.

Table 4386 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSACMHCP_PEA_1_P2.

DESCRIPTION FOR CLUSTER HSHE4MR

Cluster HSHE4MR features 5 transcript(s) and 10 segment(s) of interest, the names for which are given in Tables 4387 and 4388, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4389.

Table 4387 - Transcripts of interest

Transcript Name

HSHE4MR PEA 1 T4

HSHE4MR PEA 1 T6

HSHE4MR PEA 1 T8 HSHE4MR PEA 1 T9

HSHE4MR PEA 1 T13

Table 4388 - - Segments of interest

Segment Name

HSHE4MR PEA 1 node 0

HSHE4MR PEA 1 node 3

HSHE4MR PEA 1 node 5

HSHE4MR PEA 1 node 6

HSHE4MR PEA 1 node 7

HSHE4MR PEA 1 node 10

HSHE4MR PEA 1 node 11

HSHE4MR PEA 1 node 12

HSHE4MR PEA 1 node 13

HSHE4MR PEA 1 node 16

Table 4389 - Proteins of interest

These sequences are variants of the known protein WAP four-disulfide core domain protein 2 precursor (SwissProt accession identifier WFD2_HUMAN; known also according to the synonyms Major epididymis- specific protein E4; Epididymal secretory protein E4; Putative protease inhibitor WAP5), referred to herein as the previously known protein.

The sequence for protein WAP four-disulfide core domain protein 2 precursor is given at the end of the application, as "WAP four-disulfide core domain protein 2 precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4390.

Table 4390 - Amino acid mutations for Known Protein

Protein WAP four- disulfide core domain protein 2 precursor localization is believed to be Secreted (Potential).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: proteolysis and peptidolysis; spermatogenesis, which are annotation(s) related to Biological Process; proteinase inhibitor, which are annotation(s) related to Molecular Function; and extracellular space, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HSHE4MR can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 113 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 113 and Table 4391. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: ovarian carcinoma and uterine malignancies.

Table 4391 - Normal tissue distribution

Table 4392 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 4393.

Table 4393 - Oligonucleotides related to this cluster

As noted above, cluster HSHE4MR features 10 segment(s), which were listed in Table 4388 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSHE4MR_PEA_l_node_0 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MRJPEA_1_T6 and HSHE4MR_PEA_1_T13. Table 4394 below describes the starting and ending position of this segment on each transcript. Table 4394 - Segment location on transcripts

This segment can be found in the following protein(s): HSHE4MR_PEA_1_P3.

Segment cluster HSHE4MR_PEA_l_node_3 according to the present invention is supported by 115 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MR_PEA_1_T6 and HSHE4MR_PEA_1_T13. Table 4395 below describes the starting and ending position of this segment on each transcript.

Table 4395 - Segment location on transcripts

This segment can be found in the following protein(s): HSHE4MR_PEA_1_P3.

Segment cluster HSHE4MR_PEA_l_node_5 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MRJPEA_1_T8. Table 4396 below describes the starting and ending position of this segment on each transcript.

Table 4396 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 4397.

Table 4397 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HSHE4MRJPEA_1_P5.

Segment cluster HSHE4MR_PEA_l_node_6 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MR_PEA_1_T6, HSHE4MR_JPEA_1_T8 and HSHE4MR_PEA_1_T13. Table 4398 below describes the starting and ending position of this segment on each transcript.

Table 4398 - Segment location on transcripts

This segment can be found in the following protein(s): HSHE4MR_PEA_1_P3 and HSHE4MRJPEA_1_P5.

Segment cluster HSHE4MR_PEA_l_node_7 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MR_PEA_1_T6, HSHE4MRJPEAJ_T8 and HSHE4MR_PEA_1_T13. Table 4399 below describes the starting and ending position of this segment on each transcript.

Table 4399 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSHE4MRJPEAJJP3 and HSHE4MR_PEA_1_P5.

Segment cluster HSHE4MR_PEA_l_node_10 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MR_PEA_1_T4 and HSHE4MR_PEA_1_T9. Table 4400 below describes the starting and ending position of this segment on each transcript.

Table 4400 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSHE4MR_PEA_1_P8. Segment cluster HSHE4MR_PEA_l_node_l 1 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MRJPEA 1 T4 and HSHE4MRJPEA_1_T9. Table 4401 below describes the starting and ending position of this segment on each transcript.

Table 4401 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSHE4MR_PEA_1_P8.

Segment cluster HSHE4MR_PEA_l_node_12 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MR_PEA_1_T4. Table 4402 below describes the starting and ending position of this segment on each transcript.

Table 4402 - Segment location on transcripts

This segment can be found in the following protein(s): HSHE4MR_PEA_1JP8.

Segment cluster HSHE4MR_PEA_l_node_13 according to the present invention is supported by 145 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MR_PEA_1_T4, HSHE4MR_PEA_1_T6, HSHE4MR_PEA_1_T8, HSHE4MR_PEA_1_T9 and HSHE4MR_PEA_1_T13. Table 4403 below describes the starting and ending position of this segment on each transcript. Table 4403 - Segment location on transcripts

Tin^'s segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSHE4MR_PEA_1_P3 and HSHE4MR_PEA_1_P5. This segment can also be found in the following protein(s): HSHE4MR_PEA_1_P8, since it is in the coding region for the corresponding transcript.

Segment cluster HSHE4MR_PEA_l_node_16 according to the present invention is supported by 116 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSHE4MR_PEA_1_T4, HSHE4MRJPEA_1_T6, HSHE4MR_PEA_1_T8, HSHE4MR_PEA_1_T9 and HSHE4MR_PEA_1_T13. Table 4404 below describes the starting and ending position of this segment on each transcript.

Table 4404 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSHE4MR_PEA_1JP8, HSHE4MR_PEA_1_P3 and HSHE4MR PEA 1 P5.

DESCRIPTION FOR CLUSTER HSMRPl Cluster HSMRPl features 1 transcript(s) and 20 segment(s) of interest, the names for which are given in Tables 4405 and 4406, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4407.

Table 4405 - Transcripts of interest

Transcript Name

HSMRPl T5

Table 4406 - Segments of interest

Segment Name

HSMRPl node 40

HSMRPl node 41

HSMRPl node 42

HSMRPl node 48

HSMRPl node 5

HSMRPl node 6

HSMRPl node 7

HSMRPl node 8

HSMRPl node 18

HSMRPl node 24

HSMRPl node 28

HSMRPl node 31

HSMRPl node 33

HSMRPl node 34

HSMRPl node 38

HSMRPl node 39

HSMRPl node 43

HSMRPl node 44

HSMRPl node 46

HSMRPl node 47

Table 4407 - Proteins of interest

These sequences are variants of the known protein CD9 antigen (SwissProt accession identifier CD9_HUMAN; known also according to the synonyms P24; Leukocyte antigen MIC3; Motility-related protein; MRP-I), referred to herein as the previously known protein.

Protein CD9 antigen is known or believed to have the following function(s): Involved in platelet activation and aggregation. Regulates paranodal junction formation. Required for gamete fusion. Involved in cell adhesion, cell motility and tumor metastasis. The sequence for protein CD9 antigen is given at the end of the application, as "CD9 antigen amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4408.

Table 4408 - Amino acid mutations for Known Protein

Protein CD9 antigen localization is believed to be Integral membrane protein.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell motility; cell adhesion; binding/fusion of sperm to egg plasma membrane; platelet activation, which are annotation(s) related to Biological Process; protein binding, which are annotation(s) related to Molecular Function; and integral plasma membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLinlc/>.

Cluster HSMRPl can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 114 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 114 and Table 4409. This cluster is overexpressed (at least at a minimum level) in ths following pathological conditions: ovarian carcinoma.

Table 4409 - Normal tissue distribution

Table 4410 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 4411.

Table 4411 - Oligonucleotides related to this cluster

As noted above, cluster HSMRPl features 20 segment(s), which were listed in Table 4406 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSMRP l_node_40 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4412 below describes the starting and ending position of this segment on each transcript.

Table 4412 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP 1JP3.

Segment cluster HSMRP l_node_41 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4413 below describes the starting and ending position of this segment on each transcript. Table 4413 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSMRP1_P3.

Segment cluster HSMRP l_node_42 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): HSMRP1_T5. Table 4414 below describes the starting and ending position of this segment on each transcript.

Table 4414 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSMRP1_P3.

Segment cluster HSMRP l_node_48 according to the present invention is supported by 350 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4415 below describes the starting and ending position of this segment on each transcript.

Table 4415 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSMRP1_P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSMRP l_node_5 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP 1__T5. Table 4416 below describes the starting and ending position of this segment on each transcript. Table 4416 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSMRP1_P3.

Segment cluster HSMRP l_node_6 according to the present invention is supported by 319 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP 1_T5. Table 4417 below describes the starting and ending position of this segment on each transcript.

Table 4417 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSMRP1_P3.

Segment cluster HSMRP l_node_7 according to the present invention is supported by 422 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4418 below describes the starting and ending position of this segment on each transcript.

Table 4418 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 4419.

Table 4419 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HSMRP 1 JP3.

Segment cluster HSMRP l_node_8 according to the present invention is supported by 420 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4420 below describes the starting and ending position of this segment on each transcript.

Table 4420 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP 1_P3.

Segment cluster HSMRPl_node_l 8 according to the present invention is supported by 466 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4421 below describes the starting and ending position of this segment on each transcript.

Table 4421 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP 1 P3.

Segment cluster HSMRP 1 jnode_24 according to the present invention is supported by 376 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1 T5. Table 4422 below describes the starting and ending position of this segment on each transcript.

Table 4422 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP 1_P3.

Segment cluster HSMRPl_node_28 according to the present invention is supported by 360 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4423 below describes the starting and ending position of this segment on each transcript.

Table 4423 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP1 P3.

Segment cluster HSMRP l_node_31 according to the present invention is supported by 398 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4424 below describes the starting and ending position of this segment on each transcript.

Table 4424 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP 1_P3.

Segment cluster HSMRP l_node_33 according to the present invention can be found in the following transcript(s): HSMRP1_T5. Table 4425 below describes the starting and ending position of this segment on each transcript.

Table 4425 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP1_P3.

Segment cluster HSMRP l_node_34 according to the present invention is supported by 392 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP 1_T5. Table 4426 below describes the starting and ending position of this segment on each transcript.

Table 4426 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP1_P3.

Segment cluster HSMRPl_node_38 according to the present inventionis supported by 392 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP 1 T5. Table 4427 below describes the starting and ending position of this segment on each transcript.

Table 4427 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP1_P3.

Segment cluster HSMRPl_node_39 according to the present invention can be found in the following transcript(s): HSMRP1_T5. Table 4428 below describes the starting and ending position of this segment on each transcript.

Table 4428 - Segment location on transcripts

This segment can be found in the following protein(s): HSMRP1_P3.

Segment cluster HSMRP l_node_43 according to the present invention is supported by 361 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP1_T5. Table 4429 below describes the starting and ending position of this segment on each transcript.

Table 4429 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSMRP1_P3.

Segment cluster HSMRP l_node_44 according to the present invention is supported by 353 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP 1_T5. Table 4430 below describes the starting and ending position of this segment on each transcript.

Table 4430 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSMRP 1_P3.

Segment cluster HSMRP l_node_46 according to the present invention is supported by 341 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSMRP 1_T5. Table 4431 below describes the starting and ending position of this segment on each transcript.

Table 4431 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSMRP 1JP3.

Segment cluster HSMRPl_node_47 according to the present invention can be found in the following transcript(s): HSMRP 1_T5. Table 4432 below describes the starting and ending position of this segment on each transcript.

Table 4432 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSMRP1_P3.

DESCRIPTION FOR CLUSTER HSPPI

Cluster HSPPI features 1 transcript(s) and 11 segment(s) of interest, the names for which are given in Tables 4433 and 4434, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4435. Table 4433 - Transcripts of interest

Transcript Name HSPPI PEA 1 T3 I

Table 4434 - Segments of interest

Segment Name

HSPPI PEA 1 node 2

HSPPI PEA 1 node 13

HSPPI PEA 1 node 0

HSPPI PEA 1 node 1

HSPPI PEA 1 node 3

HSPPI PEA 1 node 4

HSPPI PEA 1 node 5

HSPPI PEA 1 node 6

HSPPI PEA 1 node 10

HSPPI PEA 1 node 11

HSPPI PEA 1 node 12

Table 4435 - Proteins of interest

These sequences are variants of the known protein Insulin precursor (SwissProt accession identifier INSJHUMAN), referred to herein as the previously known protein.

Protein Insulin precursor is known or believed to have the following function(s): Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. The sequence for protein Insulin precursor is given at the end of the application, as "Insulin precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4436.

Table 4436 - Amino acid mutations for Known Protein

Protein Insulin precursor localization is believed to be Secreted.

The previously known protein also has the following indication(s) and/or potential therapeutic use(s): Diabetes, Type I; Diabetes, Type II; Cardiomyopathy, diabetic; Diabetes; Wound healing. It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Insulin agonist; Interleukin 10 agonist; Interleukin 4 agonist; Immunomodulator. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Antidiabetic; Insulin; Symptomatic antidiabetic; Cardiovascular; Growth hormone; Vulnerary. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: glucose metabolism; energy pathways; lipid metabolism; cell surface receptor linked signal transduction; cell-cell signaling; physiological processes, which are annotation(s) related to Biological Process; insulin receptor ligand; hormone, which are annotation(s) related to Molecular Function; and extracellular, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http ://www.ncbi.nlm.nih. gov/proj ects/LocusLink/>.

As noted above, cluster HSPPI features 11 segment(s), which were listed in Table 4434 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSPPI_PEA_l_node_2 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4437 below describes the starting and ending position of this segment on each transcript.

Table 4437 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSPPI_PEA_1 JP8.

Segment cluster HSPPI_PEA_l_node_13 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4438 below describes the starting and ending position of this segment on each transcript.

Table 4438 - Segment location on transcripts

This segment can be found in the following protein(s): HSPPI_PEA_1_P8.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster HSPPI_PEA_l_node_0 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPPI_PEA__1_T3. Table 4439 below describes the starting and ending position of this segment on each transcript.

Table 4439 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSPPIJPEAJJP8.

Segment cluster HSPPI_PEA_l_node_l according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4440 below describes the starting and ending position of this segment on each transcript.

Table 4440 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSPPI_PEA_1_P8.

Segment cluster HSPPIJPEA_l_node_3 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in, the following transcript(s): HSPPI_PEA_1_T3. Table 4441 below describes the starting and ending position of this segment on each transcript.

Table 4441 - Segment location on transcripts

This segment can be found in the following protein(s): HSPPI_PEA_1_P8.

Segment cluster HSPPI_PEA_l_node_4 according to the present invention can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4442 below describes the starting and ending position of this segment on each transcript.

Table 4442 - Segment location on transcripts

This segment can be found in the following protein(s): HSPPI_PEA_1_P8.

Segment cluster HSPPI_PEA_l_node_5 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4443 below describes the starting and ending position of this segment on each transcript.

Table 4443 - Segment location on transcripts

This segment can be found in the following protein(s): HSPPI_PEA_1JP8.

Segment cluster HSPPI_PEA_l_node_6 according to the present invention can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4444 below describes the starting and ending position of this segment on each transcript.

Table 4444 - Segment location on transcripts

This segment can be found in the following protein(s): HSPPI_PEA_1_P8. Segment cluster HSPPI_PEA_l_node_l 0 according to the present invention can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4445 below describes the starting and ending position of this segment on each transcript.

Table 4445 - Segment location on transcripts

This segment can be found in the following protein(s): HSPPI_PEA_1_P8.

Segment cluster HSPPI_PEA_l_node_l 1 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4446 below describes the starting and ending position of this segment on each transcript.

Table 4446 - Segment location on transcripts

This segment can be found in the following protein(s): HSPPI_PEA_1_P8.

Segment cluster HSPPIJPEA_l_node_12 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPPI_PEA_1_T3. Table 4447 below describes the starting and ending position of this segment on each transcript.

Table 4447 - Segment location on transcripts

This segment can be found in the following protein(s): HSPPI_PEA_1_P8. DESCRIPTION FOR CLUSTER HSRR2SS

Cluster HSRR2SS features 1 transcript(s) and 21 segment(s) of interest, the names for which are given in Tables 4448 and 4449, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4450.

Table 4448 - Transcripts if interest

Transcript Name

HSRR2SS PEA 1 T9

Table 4449 - Segments of interest

Segment Name - -

HSRR2SS PEA 1 node 0

HSRR2SS PEA 1 node 29

HSRR2SS PEA 1 node 44

HSRR2SS PEA 1 node 46

HSRR2SS PEA 1 node 49

HSRR2SS PEA 1 node 2

HSRR2SS PEA 1 node 3

HSRR2SS PEA 1 node 5

HSRR2SS PEA 1 node 8

HSRR2SS PEA 1 node 9

HSRR2SS PEA 1 node 10

HSRR2SS PEA 1 node 11

HSRR2SS PEA 1 node 12

HSRR2SS PEA 1 node 15

HSRR2SS PEA 1 node 19

HSRR2SS. PEA 1 node 20

HSRR2SS PEA 1 node 21

HSRR2SS PEA 1 node 27

HSRR2SS PEA 1 node 32

HSRR2SS PEA 1 node 34

HSRR2SS PEA 1 node 42 Table 4450 - Proteins of interest

These sequences are variants of the known protein Ribonucleoside-diphosphate reductase M2 chain (SwissProt accession identifier RIR2_HUMAN; known also according to the synonyms EC 1.17.4.1; Ribonucleotide reductase small chain), referred to herein as the previously known protein.

Protein Ribonucleoside-diphosphate reductase M2 chain is known or believed to have the following function(s): Provides the precursors necessary for DNA synthesis. The sequence for protein Ribonucleoside-diphosphate reductase M2 chain is given at the end of the application, as "Ribonucleoside-diphosphate reductase M2 chain amino acid sequence". Protein

Ribonucleoside-diphosphate reductase M2 chain localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: DNA replication; deoxyribonucleoside diphosphate metabolism, which are annotation(s) related to Biological Process; ribonucleoside-diphosphate reductase; oxidoreductase, which are annotation(s) related to Molecular Function; and cytoplasm, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HSRR2SS can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 115 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 115 and Table 4451. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, colorectal cancer, epithelial malignant tumors, a mixture of malignant tumors from different tissues, hepatocellular carcinoma, lung malignant tumors, myosarcoma, pancreas carcinoma, skin malignancies and gastric carcinoma.

Table 4451 - Norma! tissue distribution

Table 4452 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSRR2SS features 21 segment(s), which were listed in Table 4449 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSRR2SS_PEA_l_node_0 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4453 below describes the starting and ending position of this segment on each transcript. Table 4453 - Segment location on transcripts

This segment can be found in the following protein(s): HSKR2SSJPEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_29 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4454 below describes the starting and ending position of this segment on each transcript.

Table 4454 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_ l_P20.

Segment cluster HSRR2SS_PEA_l_node_44 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1 _T9. Table 4455 below describes the starting and ending position of this segment on each transcript.

Table 4455 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_46 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4456 below describes the starting and ending position of this segment on each transcript.

Table 4456 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSRR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_49 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4457 below describes the starting and ending position of this segment on each transcript.

Table 4457 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSRR2SS_PEA_l_P20.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSRR2SS_PEA_l_node_2 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4458 below describes the starting and ending position of this segment on each transcript.

Table 4458 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SSJPEA_l_P20. Segment cluster HSRR2SS_PEA_l_node_3 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4459 below describes the starting and ending position of this segment on each transcript.

Table 4459 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS JΕAJ P20.

Segment cluster HSRR2SS_PEA_l_node_5 according to the present invention can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4460 below describes the starting and ending position of this segment on each transcript.

Table 4460 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_8 according to the present invention can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4461 below describes the starting and ending position of this segment on each transcript.

Table 4461 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_1JP2O.

Segment cluster HSRR2SS_PEA_l_node_9 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4462 below describes the starting and ending position of this segment on each transcript.

Table 4462 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR28S_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_10 according to the present invention can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4463 below describes the starting and ending position of this segment on each transcript. Table 4463 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SSJPEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_l 1 according to the present invention can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4464 below describes the starting and ending position of this segment on each transcript.

Table 4464 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_12 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SSJPEA_1_T9. Table 4465 below describes the starting and ending position of this segment on each transcript. Table 4465 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_15 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4466 below describes the starting and ending position of this segment on each transcript.

Table 4466 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_19 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4467 below describes the starting and ending position of this segment on each transcript.

Table 4467 - Segment location on transcripts

This segment can be found in the following protein(s): HSRJR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_20 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4468 below describes the starting and ending position of this segment on each transcript. Table 4468 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS PEA 1 P20.

Segment cluster HSRR2SS_PEA_1 jnode_21 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4469 below describes the starting and ending position of this segment on each transcript.

Table 4469 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_l_P20.

Segment cluster HSRR2SSJPEA_l_node_27 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4470 below describes the starting and ending position of this segment on each transcript.

Table 4470 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_1 jnode_32 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4471 below describes the starting and ending position of this segment on each transcript. Table 4471 - Segment location on transcripts

This segment can be found in the following protein(s): HSRJR2SS_PEA_l_P20.

Segment cluster HSRR2SS_PEA_l_node_34 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SSJPEA_1_T9. Table 4472 below describes the starting and ending position of this segment on each transcript.

Table 4472 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS PEA 1JP20.

Segment cluster HSRR2SS_PEA_l_node_42 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSRR2SS_PEA_1_T9. Table 4473 below describes the starting and ending position of this segment on each transcript.

Table 4473 - Segment location on transcripts

This segment can be found in the following protein(s): HSRR2SS_PEA_l_P20. DESCRIPTION FOR CLUSTER HSTCRT3E

Cluster HSTCRT3E features 6 transcript(s) and 12 segment(s) of interest, the names for which are given in Tables 4474 and 4475, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4476.

Table 4474 - Transcripts of interest

Transcript Name

HSTCRT3E TO

HSTCRT3E Tl

HSTCRT3E T2

HSTCRT3E T3

HSTCRT3E T5

HSTCRT3E T13

Table 4475 - Segments of interest

Segment Name

HSTCRT3E node 0

HSTCRT3E node 13

HSTCRT3E node 14

HSTCRT3E node 18

HSTCRT3E_ _node_ _24

HSTCRT3E node 2

HSTCRT3E node 3

HSTCRT3E node 5

HSTCRT3E node 8

HSTCRT3E node 11

HSTCRT3E node 20

HSTCRT3E node 23

Table 4476 - Proteins of interest

These sequences are variants of the known protein T- cell surface glycoprotein CD3 epsilon chain precursor (SwissProt accession identifier CD3E_HUMAN; known also according to the synonyms T-cell surface antigen T3/Leu-4 epsilon chain), referred to herein as the previously known protein.

Protein T-cell surface glycoprotein CD3 epsilon chain precursor is known or believed to have the following function(s): The CD3 complex mediates signal transduction. The sequence for protein T-cell surface glycoprotein CD3 epsilon chain precursor is given at the end of the application, as "T-cell surface glycoprotein CD3 epsilon chain precursor amino acid sequence". Protein T-cell surface glycoprotein CD3 epsilon chain precursor localization is believed to be Type I membrane protein.

It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: CD 19 antagonist; CD3 antagonist; T cell inhibitor. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Antidiabetic; Immunosuppressant; Antiarthritic, immunological; Monoclonal antibody, humanized; Monoclonal antibody, murine; Anticancer; Monoclonal antibody, human. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein complex assembly; signal complex formation; G-protein coupled receptor protein signaling pathway, which are annotation(s) related to Biological Process; transmembrane receptor; SH3 -domain binding; receptor signaling complex scaffold protein, which are annotation(s) related to Molecular Function; and integral plasma membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HSTCRT3E can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 116 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 116 and Table 4477. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: pancreas carcinoma.

Table 4477 - Normal tissue distribution

Table 4478 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSTCRT3E features 12 segment(s), which were listed in Table 4475 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSTCRT3E_node_0 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTCRT3E T0, HSTCRT3E_T2, HSTCRT3E_T5 and HSTCRT3E_T13. Table 4479 below describes the starting and ending position of this segment on each transcript.

Table 4479 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTCRT3E_P2 and HSTCRT3E_P3.

Segment cluster HSTCRT3E_node_13 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTCRT3E_T5. Table 4480 below describes the starting and ending position of this segment on each transcript.

Table 4480 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSTCRT3E_node_14 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTCRT3EJTO, HSTCRT3E_T1, HSTCRT3E_T2, HSTCRT3E_T3 and HSTCRT3E_T5. Table 4481 below describes the starting and ending position of this segment on each transcript.

Table 4481 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3E_P2 and HSTCRT3E_P3.

Segment cluster HSTCRT3E_node_18 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTCRT3E_T0, HSTCRT3E_T1, HSTCRT3E_T2, HSTCRT3E_T3 and HSTCRT3E_T5. Table 4482 below describes the starting and ending position of this segment on each transcript.

Table 4482 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3E_P2 and HSTCRT3E P3.

Segment cluster HSTCRT3E_node_24 according to the present invention is supported by 75 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTCRT3E_T0, HSTCRT3E_T1, HSTCRT3E_T2, HSTCRT3E_T3, HSTCRT3E_T5 and HSTCRT3E_T13. Table 4483 below describes the starting and ending position of this segment on each transcript.

Table 4483 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3E_P2 and

HSTCRT3E P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSTCRT3E_node_2 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTCRT3E_T1 and HSTCRT3E_T3. Table 4484 below describes the starting and ending position of this segment on each transcript.

Table 4484 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTCRT3EJP2 and HSTCRT3E_P3. Segment cluster HSTCRT3E_node_3 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTCRT3E_T0, HSTCRT3E_T1, HSTCRT3E_T2, HSTCRT3E_T3, HSTCRT3E_T5 and HSTCRT3E_T13. Table 4485 below describes the starting and ending position of this segment on each transcript.

Table 4485 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3E_P2 and HSTCRT3E_P3.

Segment cluster HSTCRT3E_node_5 according to the present invention can be found in the following transcript(s): HSTCRT3E_T0, HSTCRT3E_T1, HSTCRT3E_T2, HSTCRT3E_T3, HSTCRT3E_T5 and HSTCRT3E_T13. Table 4486 below describes the starting and ending position of this segment on each transcript. Table 4486 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3E_P2 and HSTCRT3E P3. Segment cluster HSTCRT3E_node_8 according to the present invention can be found in the following transcript(s): HSTCRT3E_T2 and HSTCRT3E_T3. Table 4487 below describes the starting and ending position of this segment on each transcript.

Table 4487 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3E_P3.

Segment cluster HSTCRT3E_node_l 1 according to the present invention can be found in the following transcript(s): HSTCRT3E_T0, HSTCRT3E_T1, HSTCRT3E_T2, HSTCRT3E_T3, HSTCRT3E_T5 and HSTCRT3E_T13. Table 4488 below describes the starting and ending position of this segment on each transcript.

Table 4488 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3E_P2 and HSTCRT3E P3.

Segment cluster HSTCRT3E_node_20 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTCRT3E_T0, HSTCRT3E_T1, HSTCRT3E_T2, HSTCRT3E_T3, HSTCRT3E_T5 and HSTCRT3E_T13. Table 4489 below describes the starting and ending position of this segment on each transcript. Table 4489 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3E_P2 and HSTCRT3E_P3.

Segment cluster HSTCRT3E_node_23 according to the present invention can be found in the following transcript(s): HSTCRT3E_T0, HSTCRT3E_T1, HSTCRT3E_T2, HSTCRT3E_T3, HSTCRT3E_T5 and HSTCRT3E_T13. Table 4490 below describes the starting and ending position of this segment on each transcript. Table 4490 - Segment location on transcripts

This segment can be found in the following protein(s): HSTCRT3EJP2 and HSTCRT3E P3.

DESCRIPTION FOR CLUSTER HSTFE3 Cluster HSTFE3 features 2 transcript(s) and 36 segment(s) of interest, the names for which are given in Tables 4491 and 4492, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4493.

Table 4491 - Transcripts of interest

Transcript Name

HSTFE3 PEA 1 T16

HSTFE3 PEA 1 T22

Table 4492 - Segments of interest

Segment Name

HSTFE3 PEA 1 node 5

HSTFE3 PEA 1 node 14

HSTFE3 PEA 1 node 17

HSTFE3 PEA 1 node 31

HSTFE3 PEA 1 node 35

HSTFE3 PEA 1 node 36

HSTFE3 PEA 1 node 38

HSTFE3 PEA 1 node 39

HSTFE3 PEA 1 node 41

HSTFE3 PEA 1 node 47

HSTFE3 PEA 1 node 49

HSTFE3 PEA 1 node 51

HSTFE3 PEA 1 node 55

HSTFE3 PEA 1 node 59

HSTFE3 PEA 1 node 60

HSTFE3 PEA 1 node 7

HSTFE3 PEA 1 node 11

HSTFE3 PEA 1 node 12

HSTFE3 PEA 1 node 13

HSTFE3 PEA 1 node 19

HSTFE3 PEA 1 node 28

HSTFE3 PEA 1 node 30

HSTFE3 PEA 1 node 32

HSTFE3 PEA 1 node 33

HSTFE3 PEA 1 node 34

HSTFE3 PEA 1 node 42

HSTFE3 PEA 1 node 43

HSTFE3 PEA 1 node 45

HSTFE3 PEA 1 node 48 HSTFE3 PEA 1 node 50

HSTFE3 PEA 1 node 52

HSTFE3 PEA 1 node 53

HSTFE3 PEA 1 node 54

HSTFE3 PEA 1 node 56

HSTFE3 PEA 1 node 57

HSTFE3 PEA 1 node 58

Table 4493 - Proteins of interest

These sequences are variants of the known protein Transcription factor E3 (SwissProt accession identifier TFE3_HUMAN), referred to herein as the previously known protein.

Protein Transcription factor E3 is known or believed to have the following function(s): Positive- acting transcription factor that binds to the immunoglobulin enchancer MUE3 motif. It binds also very well to a USF/MLTF site. Binding of TFE3 to DNA induces DNA binding. The sequence for protein Transcription factor E3 is given at the end of the application, as "Transcription factor E3 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4494.

Table 4494 - Amino acid mutations for Known Protein

Protein Transcription factor E3 localization is believed to be Nuclear. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription regulation; transcription, from Pol II promoter; cell growth and/or maintenance, which are annotation(s) related to Biological Process; transcription factor, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster HSTFE3 features 36 segment(s), which were listed in Table 4492 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSTFE3JPEA_l_node_5 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4495 below describes the starting and ending position of this segment on each transcript.

Table 4495 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3JPEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_14 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3 JPEA_1_T22. Table 4496 below describes the starting and ending position of this segment on each transcript.

Table 4496 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_17 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3JPEA_1_T22. Table 4497 below describes the starting and ending position of this segment on each transcript.

Table 4497 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_31 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3JPEA_1_T22. Table 4498 below describes the starting and ending position of this segment on each transcript.

Table 4498 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_35 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4499 below describes the starting and ending position of this segment on each transcript.

Table 4499 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3JPEA_l_node_36 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3JPEA_1_T22. Table 4500 below describes the starting and ending position of this segment on each transcript.

Table 4500 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_38 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4501 below describes the starting and ending position of this segment on each transcript.

Table 4501 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_1JP5. Segment cluster HSTFE3_PEA_l_node_39 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4502 below describes the starting and ending position of this segment on each transcript.

Table 4502 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_41 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4503 below describes the starting and ending position of this segment on each transcript.

Table 4503 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_47 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4504 below describes the starting and ending position of this segment on each transcript.

Table 4504 - Segment location on transcripts

HSTFE3 PEA 1 T16 | 778 | 997 |

This segment can be found in the following protein(s): HSTFE3_PEA_1 _P10.

Segment cluster HSTFE3_PEA_l_node_49 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4505 below describes the starting and ending position of this segment on each transcript.

Table 4505 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_51 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4506 below describes the starting and ending position of this segment on each transcript.

Table 4506 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_55 according to the present invention is supported by 163 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4507 below describes the starting and ending position of this segment on each transcript. Table 4507 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_1 J^»10.

Segment cluster HSTFE3_PEA_l_node_59 according to the present invention is supported by 136 libraπes. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4508 below describes the starting and ending position of this segment on each transcript.

Table 4508 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following ρrotein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_60 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4509 below describes the starting and ending position of this segment on each transcript.

Table 4509 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSTFE3JPEA_l_node_7 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4510 below describes the starting and ending position of this segment on each transcript.

Table 4510 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_l 1 according to the present invention can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4511 below describes the starting and ending position of this segment on each transcript.

Table 4511 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_12 according to the present invention can be found in the following transcript(s): HSTFE3_PEA_ 1_T22. Table 4512 below describes the starting and ending position of this segment on each transcript.

Table 4512 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_1JP5.

Segment cluster HSTFE3_PEA_l_node_13 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4513 below describes the starting and ending position of this segment on each transcript.

Table 4513 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3JPEA_l_node_19 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4514 below describes the starting and ending position of this segment on each transcript.

Table 4514 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_ 1_P5.

Segment cluster HSTFE3_PEA_l_node__28 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3JPEA_1_T22. Table 4515 below describes the starting and ending position of this segment on each transcript.

Table 4515 - Segment location on transcripts

I HSTFE3 PEA 1 T22 | I 1146 I I 1263 I

This segment can be found in the following protein(s): HSTFE3J^>EA_1_P5.

Segment cluster HSTFE3JPEA_l_node_30 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4516 below describes the starting and ending position of this segment on each transcript.

Table 4516 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3JPEA_l_node_32 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4517 below describes the starting and ending position of this segment on each transcript.

Table 4517 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_33 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4518 below describes the starting and ending position of this segment on each transcript. Table 4518 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSTFE3JPEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_34 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T22. Table 4519 below describes the starting and ending position of this segment on each transcript.

Table 4519 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_1_P5.

Segment cluster HSTFE3_PEA_l_node_42 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4520 below describes the starting and ending position of this segment on each transcript.

Table 4520 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_43 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4521 below describes the starting and ending position of this segment on each transcript.

Table 4521 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_45 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3JPEA_1_T16. Table 4522 below describes the starting and ending position of this segment on each transcript.

Table 4522 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_48 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4523 below describes the starting and ending position of this segment on each transcript.

Table 4523 - Segment location on transcripts

This segment can be found in the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_50 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1__T16. Table 4524 below describes the starting and ending position of this segment on each transcript.

Table 4524 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_52 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following trarscript(s): HSTFE3_PEA_1_T16. Table 4525 below describes the starting and ending position of this segment on each transcript.

Table 4525 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster H8TFE3_PEA_l_node_53 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4526 below describes the starting and ending position of this segment on each transcript.

Table 4526 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10. Segment cluster HSTFE3_PEA_l_node_54 according to the present invention can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4527 below describes the starting and ending position of this segment on each transcript. Table 4527 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3_PEA_l_node_56 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4528 below describes the starting and ending position of this segment on each transcript.

Table 4528 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10.

Segment cluster HSTFE3JPEA_l_node_57 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSTFE3_PEA_1_T16. Table 4529 below describes the starting and ending position of this segment on each transcript.

Table 4529 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_1JP 10.

Segment cluster HSTFE3_PEA_l_node_58 according to the present invention can be found in the following transcript(s): HSTFE3JPEA_1_T16. Table 4530 below describes the starting and ending position of this segment on each transcript.

Table 4530 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSTFE3_PEA_l_P10.

DESCRIPTION FOR CLUSTER HUMANFB

Cluster HUMANFB features 7 transcript(s) and 44 segment(s) of interest, the names for which are given in Tables 4531 and 4532, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4533.

Table 4531 - Transcripts of interest

Transcript Name

HUMANFB PEA 1 T24

HUMANFB PEA 1 T26

HUMANFB PEA 1 T29

HUMANFB PEA 1 T34

HUMANFB PEA 1 T35

HUMANFB PEA 1 T40

HUMANFB PEA 1 T45 Table 4532 - Segments of interest

Segment Name

HUMANFB PEA 1 node 0

HUMANFB PEA 1 node 24

HUMANFB PEA 1 node 39

HUMANFB PEA 1 node 47

HUMANFB PEA 1 node 49

HUMANFB PEA 1 node 51

HUMANFB PEA 1 node 55

HUMANFB PEA 1 node 57

HUMANFB_ PEA 1_ node 60

HUMANFB PEA 1 node 64

HUMANFB PEA 1 node 65

HUMANFB PEA 1 node 71

HUMANFB PEA 1 node 72

HUMANFB PEA 1 node 73

HUMANFB PEA 1 node 80

HUMANFB PEA 1 node 83

HUMANFB PEA 1 node 93

HUMANFB PEA 1 node 95

HUMANFB PEA 1 node 4

HUMANFB PEA 1 node 6

HUMANFB PEA 1 node 8

HUMANFB PEA 1 node 9

HUMANFB PEA 1 node 11

HUMANFB PEA 1 node 12

HUMANFB PEA 1 node 17

HUMANFB PEA 1 node 18

HUMANFB PEA 1 node 26

HUMANFB PEA 1 node 28

HUMANFB PEA 1 node 31

HUMANFB PEA 1 node 32

HUMANFB PEA 1 node 35

HUMANFB PEA 1 node 38

HUMANFB PEA 1 node 41

HUMANFB PEA 1 node 42

HUMANFB PEA 1 node 53

HUMANPB PEA 1 node 59

HUMANFB PEA 1 node 62

HUMANFB PEA 1 node 68

HUMANFB PEA 1 node 69

HUMANFB PEA 1 node 70 HUMANFB PEA 1 node 77

HUMANFB PEA 1 node 78

HUMANFB PEA 1 node 92

HUMANFB PEA 1 node 94

Table 4533 - Proteins of interest

These sequences are variants of the known protein Chloride channel protein 6 (SwissProt accession identifier CLC6_HUMAN; known also according to the synonyms ClC -6), referred to herein as the previously known protein.

Protein Chloride channel protein 6 is known or believed to have the following function(s): Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. The sequence for protein Chloride channel protein 6 is given at the end of the application, as "Chloride channel protein 6 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4534.

Table 4534 - Amino acid mutations for Known Protein

Protein Chloride channel protein 6 localization is believed to be Integral membrane protein. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transport; ion transport; chloride transport; cell volume regulation; signal transduction, which are annotation(s) related to Biological Process; voltage-gated chloride channel, which are annotation(s) related to Molecular Function; and membrane fraction; integral plasma membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on infoπnation from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster HUMANFB. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y-axis of Figure 117 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 117, concerning the number of heart- specific clones in libraries/sequences.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 19.3; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 370.1 ; and fisher exact test P-values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 6.40E-102.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 19.3, which clearly supports specific expression in heart tissue.

As noted above, cluster HUMANFB features 44 segment(s), which were listed in Table 4532 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMANFB_PEA_l_node_0 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFBJPEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4535 below describes the starting and ending position of this segment on each transcript. Table 4535 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12. Segment cluster HUMANFB_PEA_l_node_24 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4536 below describes the starting and ending position of this segment on each transcript.

Table 4536 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_39 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34,

HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4537 below describes the starting and ending position of this segment on each transcript.

Table 4537 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_47 according to the present invention is supported by 37 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA__1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB JPEA_ 1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4538 below describes the starting and ending position of this segment on each transcript.

Table 4538 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB PEA 1 P1, HUMANFB_PEA_1_P17 and HUMANFB_PEA_1_P12.

Segment cluster HUMANFB_PEA_l_node_49 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_ 1_T29, HUMANFBJPEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4539 below describes the starting and ending position of this segment on each transcript.

Table 4539 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_51 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFBJPEAJ_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4540 below describes the starting and ending position of this segment on each transcript.

Table 4540 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB_PEA_1_P17 and HUMANFB_PEA_1_P12.

Segment cluster HUMANFB_PEA_l_node_55 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFBJPEAJ _T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFBJPEAJ_T40 and HUMANFB_PEA_1_T45. Table 4541 below describes the starting and ending position of this segment on each transcript.

Table 4541 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB PEA 1JP1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_57 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEAJ_T40 and HUMANFB_PEA_1_T45. Table 4542 below describes the starting and ending position of this segment on each transcript. Table 4542 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFBJPEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12. Segment cluster HUMANFB_PEA_l_node_60 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEAJ_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4543 below describes the starting and ending position of this segment on each transcript.

Table 4543 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1,

HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_64 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4544 below describes the starting and ending position of this segment on each transcript.

Table 4544 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P12. This segment can also be found in the following protein(s): HUMANFB_PEA_1_P1 and HUMANFB_PEA_1_P17, since it is in the coding region for the corresponding transcript.

Segment cluster HUMANFB_PEA_l_node_65 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4545 below describes the starting and ending position of this segment on each transcript.

Table 4545 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P12. This segment can also be found in the following protein(s): HUMANFB_PEA_1_P17, since it is in the coding region for the corresponding transcript.

Segment cluster HUMANFB_PEA_l_node_71 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34 and HUMANFB_PEA_1_T35. Table 4546 below describes the starting and ending position of this segment on each transcript. Table 4546 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P1.

Segment cluster HUMANFB_PEA_l_node_72 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34 and HUMANFB_PEA_1_T35. Table 4547 below describes the starting and ending position of this segment on each transcript.

Table 4547 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P1.

Segment cluster HUMANFB_PEA_l_node_73 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEAJ_T26 and HUMANFB_PEA_1_T29. Table 4548 below describes the starting and ending position of this segment on each transcript.

Table 4548 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P1.

Segment cluster HUMANFB_PEA_l_node_80 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29 and HUMANFB_PEA_1_T34. Table 4549 below describes the starting and ending position of this segment on each transcript.

Table 4549 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P1.

Segment cluster HUMANFB_PEA_l_node_83 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24,

HUMANFB JPEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34 and HUMANFB_PEA_1_T35. Table 4550 below describes the starting and ending position of this segment on each transcript.

Table 4550 ~ Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMANFBJPEA_1_P1.

Segment cluster HUMANFB_PEA_l_node_93 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24 and HUMANFB_PEA_ 1_T34. Table 4551 below describes the starting and ending position of this segment on each transcript.

Table 4551 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P1.

Segment cluster HUMANFB_PEA_l__node_95 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34 and HUMANFBJΕAJ _T35. Table 4552 below describes the starting and ending position of this segment on each transcript.

Table 4552 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMANFB JPEAJJU.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMANFB JPEA J _node_4 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB-PE A_1_T24, HUMANFB JPEAJ _T26, HUMANFB JPEA J _T29, HUMANFB JPEA J_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFBJΕAJ _T45. Table 4553 below describes the starting and ending position of this segment on each transcript.

Table 4553 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P 12.

Segment cluster HUMANFB_PEA_l_node_6 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFBJPEAJ _T40 and HUMANFB_PEA_1_T45. Table 4554 below describes the starting and ending position of this segment on each transcript.

Table 4554 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB JPEA_1_P17 and HUMANFB JPEA_1_P12.

Segment cluster HUMANFB_PEA_l_node_8 according to the present invention can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB JPEA_l_T40 and HUMANFB_PEA_1_T45. Table 4555 below describes the starting and ending position of this segment on each transcript.

Table 4555 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_9 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1 _T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB J^>EA_l_T40 and HUMANFB_PEA_1_T45. Table 4556 below describes the starting and ending position of this segment on each transcript.

Table 4556 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB PEA 1JP1, HUMANFB_PEA_1JP17 and HUMANFB_PEA_1_P12.

Segment cluster HUMANFB_PEA_l_node_l 1 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFBJPEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4557 below describes the starting and ending position of this segment on each transcript.

Table 4557 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_12 according to the present invention can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4558 below describes the starting and ending position of this segment on each transcript.

Table 4558 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12. Segment cluster HUMANFB_PEA_l_node_17 according to the present invention is supported by 26 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB JPEA_1_T29, HUMANFB JPEAJ _T34, HUMANFB_PEA_1_T35, HUM ANFBJPE A_l_T40 and HUMANFB JPE A_1_T45. Table 4559 below describes the starting and ending position of this segment on each transcript.

Table 4559 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB J³EA l JPl, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_18 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34,

HUMANFB_PEA_1_T35, HUM ANFB JPEA J _T40 and HUMANFB_PEA_1_T45. Table 4560 below describes the starting and ending position of this segment on each transcript.

Table 4560 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1 JPl, HUMANFB PEA 1 Pl 7 and HUMANFB PEA 1 P 12.

Segment cluster HUMANFB_PEA_l_node_26 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUM ANFBJPE A_l_T40 and HUMANFB J^>EA_1_T45. Table 4561 below describes the starting and ending position of this segment on each transcript.

Table 4561 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFBJPEA_ 1 JP17 and HUMANFB_PEA_1_P12.

Segment cluster HUMANFB_PEA_l_node_28 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB JPEAJ_T45. Table 4562 below describes the starting and ending position of this segment on each transcript.

Table 4562 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFBJPEA_1_P1, HUMANFB PEA 1 Pl 7 and HUMANFB PEA 1 Pl 2.

Segment cluster HUMANFB_PEA_l_node_31 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4563 below describes the starting and ending position of this segment on each transcript.

Table 4563 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB_PEA_1_P17 and HUMANFB JPE AJJP 12.

Segment cluster HUMANFBJPEA l jtiode_32 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB JPEA J_T26, HUMANFB_PEAJ_T29, HUMANFB_PEA_1_T34, HUMANFB J^>EAJ_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4564 below describes the starting and ending position of this segment on each transcript.

Table 4564 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_35 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_JPEA_1_T26, HUMANFB JPEAJ _T29, HUMANFB_PEA_1_T34, HUMANFB JPEAJ _T35, HUMANFB J¹EAJ _T40 and HUMANFB_PEA_1_T45. Table 4565 below describes the starting and ending position of this segment on each transcript. Table 4565 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFBJ³EAJJ³I, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12. Segment cluster HUMANFB_PEA_l_node_38 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB JPEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4566 below describes the starting and ending position of this segment on each transcript.

Table 4566 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P 1 ,

HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_41 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEAJ_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4567 below describes the starting and ending position of this segment on each transcript.

Table 4567 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB_PEA_1 J^>17 and HUMANFB_PEA_1_P12.

Segment cluster HUMANFB_PEA_l_node_42 according to the present invention can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFBJ?EA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1 _T34, HUMANFB JPEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4568 below describes the starting and ending position of this segment on each transcript. Table 4568 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 Pl 7 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_l_node_53 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4569 below describes the starting and ending position of this segment on each transcript.

Table 4569 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1, HUMANFB PEA 1 P17 and HUMANFB PEA 1 P12.

Segment cluster HUMANFB_PEA_ l_node_59 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB_PEA_1_T35 and HUMANFB_PEA_l_T40. Table 4570 below describes the starting and ending position of this segment on each transcript.

Table 4570 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1 and FfUMANFBJPEAJJP 17.

Segment cluster HUMANFB_PEA_l_node_62 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFBJPEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34, HUMANFB J^>EA_1_T35, HUMANFB_PEA_l_T40 and HUMANFB_PEA_1_T45. Table 4571 bebw describes the starting and ending position of this segment on each transcript.

Table 4571 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P12. This segment can also be found in the following protein(s): HUMANFB_PEA_1_P1 and HUMANFB_PEA_1_P17, since it is in the coding region for the corresponding transcript.

Segment cluster HUMANFB_PEA_l_node_68 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34 and HUMANFB_PEA_1_T35. Table 4572 below describes the starting and ending position of this segment on each transcript.

Table 4572 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_l_jPl. Segment cluster HUMANFBJPEA_l_node_69 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFBJPEA_1_T24, HUMANFB_PEA_J_T26, HUMANFB_PEA_1_T29, HUMANFB_PEA_1_T34 and HUMANFB_PEA_1_T35. Table 4573 below describes the starting and ending position of this segment on each transcript.

Table 4573 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFBJPEA_1_P1.

Segment cluster HUMANFB_PEA_l_node_70 according to the present invention can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEAJ_T29, HUMANFB_PEA_1_T34 and HUMANFB_PEA_1_T35. Table 4574 below describes the starting and ending position of this segment on each transcript.

Table 4574 - Segment location on transcripts

This segment can be found in the following protein(s): HUMANFB_PEA_1_P1. Segment cluster HUMANFB_PEA_l_node_77 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T34. Table 4575 below describes the starting and ending position of this segment on each transcript.

Table 4575 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1JP1.

Segment cluster HUMANFB_PEA_l_node_78 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMANFB_PEA_1_T24, HUMANFB_PEA_1_T26, HUMANFB_PEA_1_T29 and HUMANFB_PEA_1_T34. Table 4576 below describes the starting and ending position of this segment on each transcript.

Table 4576 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P1.

Segment cluster HUMANFB_PEA_l_node_92 according to the present invention can be found in the following transcript(s): HUMANFB_PEA_1_T24 and HUMANFB_PEA_1_T34. Table 4577 below describes the starting and ending position of this segment on each transcript.

Table 4577 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P1.

Segment cluster HUMANFB_PEA_l_node_94 according to the present invention can be found in the following transcript(s): HUMANFB_PEA_1_T24 and HUMANFB_PEA_1_T34. Table 4578 below describes the starting and ending position of this segment on each transcript.

Table 4578 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMANFB_PEA_1_P1.

DESCRIPTION FOR CLUSTER HUMCEA

Cluster HUMCEA features 1 transcript(s) and 23 segment(s) of interest, the names for which are given in Tables 4579 and 4580, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4581.

Table 4579 - Transcripts of interest

Transcript Name

HUMCEA PEA 1 T20

Table 4580 - Segments of interest Segment Name

HUMCEA PEA 1 node 0

HUMCEA PEA 1 node 2

HUMCEA PEA 1 node 12

HUMCEA PEA 1 node 31

HUMCEA PEA 1 node 67

HUMCEA PEA 1 node 3

HUMCEA PEA 1 node 7

HUMCEA PEA 1 node 8

HUMCEA PEA 1 node 9

HUMCEA PEA 1 node 10

HUMCEA PEA 1 node 15

HUMCEA PEA 1 node 16

HUMCEA PEA 1 node 17

HUMCEA PEA 1 node 18

HUMCEA PEA 1 node 19

HUMCEA PEA 1 node 20

HUMCEA PEA 1 node 21

HUMCEA PEA 1 node 22

HUMCEA PEA 1 node 23

HUMCEA PEA 1 node 24

HUMCEA PEA 1 node 27

HUMCEA PEA 1 node 29

HUMCEA PEA 1 node 30

Table 4581 - Proteins of interest

These sequences are variants of the known protein Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (SwissProt accession identifier CEA5JHUMAN; known also according to the synonyms Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e antigen), referred to herein as the previously known protein.

The sequence for protein Carcinoembryonic antigen-related cell adhesion molecule 5 precursor is given at the end of the application, as "C arcinoembryonic antigen- related cell adhesion molecule 5 precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4582.

Table 4582 - Amino acid mutations for Known Protein

Protein Carcinoembryonic antigen-related cell adhesion molecule 5 precursor localization is believed to be Attached to the membrane by a GPI- anchor.

The previously known protein also has the following indication(s) and/or potential therapeutic use(s): Cancer. It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Immunostimulant. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Imaging agent; Anticancer; Immunostimulant; Immunoconjugate; Monoclonal antibody, murine; Antisense therapy; antibody. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: integral plasma membrane protein; membrane, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HUMCEA can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 118 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 118 and Table 4583. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and pancreas carcinoma.

Table 4583 - Normal tissue distribution

Table 4584 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 4585.

Table 4585 - Oligonucleotides related to this cluster

As noted above, cluster HUMCEA features 23 segment(s), which were listed in Table 4580 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMCEA_PEA_l_node_0 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4586 below describes the starting and ending position of this segment on each transcript.

Table 4586 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEAJPEA l_node_2 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4587 below describes the starting and ending position of this segment on each transcript.

Table 4587 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_1 _node_12 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA JPEA_l_T20. Table 4588 below describes the starting and ending position of this segment on each transcript.

Table 4588 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_31 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4589 below describes the starting and ending position of this segment on each transcript.

Table 4589 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1JP14.

Segment cluster HUMCEA_PEA_l_node_67 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_1_T2O. Table 4590 below describes the starting and ending position of this segment on each transcript.

Table 4590 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMCEA_PEA_l_node_3 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l__T20. Table 4591 below describes the starting and ending position of this segment on each transcript.

Table 4591 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_7 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_1 _T20. Table 4592 below describes the starting and ending position of this segment on each transcript.

Table 4592 - Segment location on transcripts

HUMCEA- PEA 1 T20 |J>39 | 642 |

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEAJPEA_l_node_8 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4593 below describes the starting and ending position of this segment on each transcript.

Table 4593 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_9 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4594 below describes the starting and ending position of this segment on each transcript.

Table 4594 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEAJPEA_l_node_10 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4595 below describes the starting and ending position of this segment on each transcript.

Table 4595 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_15 according to the present invention can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4596 below describes the starting and ending position of this segment on each transcript.

Table 4596 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_ 1_P14.

Segment cluster HUMCEA_PEA_ l_node_16 according to the present invention can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4597 below describes the starting and ending position of this segment on each transcript.

Table 4597 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_17 according to the present invention can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4598 below describes the starting and ending position of this segment on each transcript.

Table 4598 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_l 8 according to the present invention can be found in the following transcript(s): HUMCEA_PEA_1 _T20. Table 4599 below describes the starting and ending position of this segment on each transcript.

Table 4599 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_JPEA__1 jnode_l 9 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA JPEA_l_T20. Table 4600 below describes the starting and ending position of this segment on each transcript. Table 4600 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_20 according to the present invention can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4601 below describes the starting and ending position of this segment on each transcript.

Table 4601 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14. Segment cluster HUMCEAJPEA_l_node_21 according to the present invention can be found in the following transcript(s): HUMCEA JPEA_l_T20. Table 4602 below describes the starting and ending position of this segment on each transcript. Table 4602 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_22 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4603 below describes the starting and ending position of this segment on each transcript.

Table 4603 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1JP14.

Segment cluster HUMCEA_PEA_l_node_23 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4604 below describes the starting and ending position of this segment on each transcript.

Table 4604 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA _PEA_1_P14. Segment cluster HUMCEA_PEA_l_node_24 according to the present invention can be found in the following transcript(s): HUMCEA_PEA_l_T20. Tabb 4605 below describes the starting and ending position of this segment on each transcript.

Table 4605 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_27 according to the present invention can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4606 below describes the starting and ending position of this segment on each transcript.

Table 4606 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_29 according to the present invention can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4607 below describes the starting and ending position of this segment on each transcript.

Table 4607 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

Segment cluster HUMCEA_PEA_l_node_30 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCEA_PEA_l_T20. Table 4608 below describes the starting and ending position of this segment on each transcript.

Table 4608 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCEA_PEA_1_P14.

DESCRIPTION FOR CLUSTER HUMCFX

Cluster HUMCFX features 2 transcript(s) and 48 segment(s) of interest, the names for which are given in Tables 4609 and 4610, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4611.

Table 4609 - Transcripts of interest

Transcript Name

HUMCFX PEA 1 Tl

HUMCFX PEA 1 T27

Table 4610 - Segments of interest

Segment Name

HUMCFX PEA 1 node 0

HUMCFX PEA 1 node 2

HUMCFX PEA 1 node 4

HUMCFX PEA 1 node 7

HUMCFX PEA 1 node 9

HUMCFX PEA 1 node 11 HUMCFX PEA 1 node 13

HUMCFX PEA 1 node 14

HUMCFX PEA 1 node 18

HUMCFX PEA 1 node 19

HUMCFX PEA 1 node 21

HUMCFX PEA 1 node 22

HUMCFX PEA 1 node 23

HUMCFX PEA 1 node 24

HUMCFX PEA 1 node 25

HUMCFX PEA 1 node 26

HUMCFX PEA 1 node 27

HUMCFX PEA 1 node 28

HUMCFX PEA 1 node 31

HUMCFX PEA 1 node 32

HUMCFX PEA 1 node 33

HUMCFX PEA 1 node 34

HUMCFX PEA 1 node 35

HUMCFX PEA 1 node 36

HUMCFX PEA 1 node 38

HUMCFX PEA 1 node 40

HUMCFX PEA 1 node 41

HUMCFX PEA 1 node 42

HUMCFX PEA 1 node 45

HUMCFX PEA 1 node 46

HUMCFX PEA 1 node 47

HUMCFX_ PEA 1 node 48

HUMCFX PEA 1 node 49

HUMCFX PEA 1 node 50

HUMCFX PEA 1 node 51

HUMCFX PEA 1 node 52

HUMCFX PEA 1 node 53

HUMCFX PEA 1 node 54

HUMCFX PEA 1 node 55

HUMCFX PEA 1 node 56

HUMCFX PEA 1 node 57

HUMCFX PEA 1 node 58

HUMCFX PEA 1 node 59

HUMCFX PEA 1 node 60

HUMCFX PEA 1 node 61

HUMCFX PEA 1 node 62

HUMCFX _PEA_ _1 jtiode _63

HUMCFX PEA 1 node 64

Table 4611 - Proteins of interest

These sequences are variants of the known protein Coagulation factor X precursor (SwissProt accession identifier FA10_HUMAN; known also according to the synonyms EC 3.4.21.6; Stuart factor; Stuart- Prower factor), referred to herein as the previously known protein.

Protein Coagulation factor X precursor is known or believed to have the following function(s): Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The sequence for protein Coagulation factor X precursor is given at the end of the application, as "Coagulation factor X precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4612.

Table 4612 - Amino acid mutations for Known Protein

It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Factor Vila inhibitor; Factor Xa inhibitor; Thrombin inhibitor; Trypsin inhibitor. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Anticoagulant; Antiinflammatory; Antithrombotic. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: proteolysis and peptidolysis; blood coagulation, which are annotation(s) related to Biobgical Process; blood coagulation factor X; chymotrypsin; trypsin; calcium binding; hydrolase, which are annotation(s) related to Molecular Function; and extracellular, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster HUMCFX features 48 segment(s), which were listed in Table 4610 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A descriptbn of each segment according to the present invention is now provided.

Segment cluster HUMCFXJPEA_l_node_0 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T27. Table 4613 below describes the starting and ending position of this segment on each transcript.

Table 4613 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMCFX_PEA_1_P16.

Segment cluster HUMCFX_PEA_l_node__2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA__1_T1. Table 4614 below describes the starting and ending position of this segment on each transcript.

Table 4614 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFXJPEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_4 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1 and HUMCFX_PEA_1_T27. Table 4615 below describes the starting and ending position of this segment on each transcript.

Table 4615 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMCFXJPEA 1 P16. This segment can also be found in the following protein(s): HUMCFX_PEA_1_P39, since it is in the coding region for the corresponding transcript.

Segment cluster HUMCFX_PEA_l_node_7 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T27. Table 4616 below describes the starting and ending position of this segment on each transcript.

Table 4616 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P16.

Segment cluster HUMCFX_PEA_l_node_9 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFXJPEA_1_T27. Table 4617 below describes the starting and ending position of this segment on each transcript.

Table 4617 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMCFX_PEA_1_P16.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMCFX_PEA_l_node_l 1 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4618 below describes the starting and ending position of this segment on each transcript.

Table 4618 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39. Segment cluster HUMCFX_PEA_l_node_l 3 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4619 below describes the starting and ending position of this segment on each transcript.

Table 4619 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_14 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4620 below describes the starting and ending position of this segment on each transcript.

Table 4620 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_18 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4621 below describes the starting and ending position of this segment on each transcript.

Table 4621 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1JP39. Segment cluster HUMCFX_PEA_l_node_19 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4622 below describes the starting and ending position of this segment on each transcript.

Table 4622 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_21 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4623 below describes the starting and ending position of this segment on each transcript.

Table 4623 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFXJPEA_l_node_22 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4624 below describes the starting and ending position of this segment on each transcript. Table 4624 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFXJPEA_1_P39. Segment cluster HUMCFX_PEA_l_node_23 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4625 below describes the starting and ending position of this segment on each transcript.

Table 4625 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_24 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4626 below describes the starting and ending position of this segment on each transcript.

Table 4626 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_25 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4627 below describes the starting and ending position of this segment on each transcript.

Table 4627 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39. Segment cluster HUMCFX_PEA_l_node_26 according to the present invention can be found in the following transcript(s): HUMCFX JPEA_1_T1. Table 4628 below describes the starting and ending position of this segment on each transcript.

Table 4628 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_27 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4629 below describes the starting and ending position of this segment on each transcript.

Table 4629 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_28 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4630 below describes the starting and ending position of this segment on each transcript.

Table 4630 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39. Segment cluster HUMCFXJPEA_l_node_31 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4631 below describes the starting and ending position of this segment on each transcript.

Table 4631 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX JPEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_32 according to the present invention can be found in the following transcript(s): HUMCFX_PEA__1_T1. Table 4632 below describes the starting and ending position of this segment on each transcript.

Table 4632 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_33 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4633 below describes the starting and ending position of this segment on each transcript.

Table 4633 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_34 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4634 below describes the starting and ending position of this segment on each transcript. Table 4634 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1JP39.

Segment cluster HUMCFX_PEA_l_node_35 according to the present invention can be found in the following transcript(s): HUMCFXJPEA_1_T1. Table 4635 below describes the starting and ending position of this segment on each transcript.

Table 4635 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFXJPEAJ JP39.

Segment cluster HUMCFX_PEA_l_node_36 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4636 below describes the starting and ending position of this segment on each transcript. Table 4636 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_38 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4637 below describes the starting and ending position of this segment on each transcript.

Table 4637 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_40 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4638 below describes the starting and ending position of this segment on each transcript.

Table 4638 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_41 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4639 below describes the starting and ending position of this segment on each transcript.

Table 4639 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_42 according to the present invention can be found in the following transcript(s): HUMCFXJPEA_1_T1. Table 4640 below describes the starting and ending position of this segment on each transcript.

Table 4640 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_45 according to the present invention can be found in the following transcript(s): HUMCFXJPEA_1 _Tl . Table 4641 below describes the starting and ending position of this segment on each transcript.

Table 4641 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFXJPEAJ_node_46 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4642 below describes the starting and ending position of this segment on each transcript. Table 4642 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_47 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4643 below describes the starting and ending position of this segment on each transcript.

Table 4643 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39. Segment cluster HUMCFX_PEA_l_node_48 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4644 below describes the starting and ending position of this segment on each transcript. Table 4644 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_49 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4645 below describes the starting and ending position of this segment on each transcript.

Table 4645 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFXJPEA 1 P39.

Segment cluster HUMCFX_PEA_l_node_50 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4646 below describes the starting and ending position of this segment on each transcript.

Table 4646 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39. Segment cluster HUMCFX_PEA_l_node_51 according to the present invention can be found in the following transcπpt(s): HUMCFX_PEA_1__T1. Table 4647 below describes the starting and ending position of this segment on each transcript.

Table 4647 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFXJPEA_l_node_52 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4648 below describes the starting and ending position of this segment on each transcript.

Table 4648 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_53 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4649 below describes the starting and ending position of this segment on each transcript.

Table 4649 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFXJPEA_l_node__54 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4650 below describes the starting and ending position of this segment on each transcript.

Table 4650 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_55 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4651 below describes the starting and ending position of this segment on each transcript.

Table 4651 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_56 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4652 below describes the starting and ending position of this segment on each transcript.

Table 4652 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFXJPEA_1_P39.

Segment cluster HUMCFX_PEA_l_node__57 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4653 below describes the starting and ending position of this segment on each transcript. Table 4653 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_58 according to the present inventbn can be found in the following transcript(s): HUMCFXJPEA_1_T1. Table 4654 below describes the starting and ending position of tins segment on each transcript.

Table 4654 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_59 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4655 below describes the starting and ending position of this segment on each transcript.

Table 4655 ~ Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_60 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4656 below describes the starting and ending position of this segment on each transcript.

Table 4656 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_1 jnode_61 according to the present invention can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4657 below describes the starting and ending position of this segment on each transcript.

Table 4657 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_62 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4658 below describes the starting and ending position of this segment on each transcript.

Table 4658 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_63 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4659 below describes the starting and ending position of this segment on each transcript.

Table 4659 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

Segment cluster HUMCFX_PEA_l_node_64 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMCFX_PEA_1_T1. Table 4660 below describes the starting and ending position of this segment on each transcript.

Table 4660 - Segment location on transcripts

This segment can be found in the following protein(s): HUMCFX_PEA_1_P39.

DESCRIPTION FOR CLUSTER HUMEB2CR2

Cluster HUMEB2CR2 features 3 transcript(s) and 23 segment(s) of interest, the names for which are given in Tables 4661 and 4662, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4663.

Table 4661 - Transcripts of interest

Transcript Name

HUMEB2CR2 PEA 1 T4

HUMEB2CR2 PEA 1 T5

HUMEB2CR2 PEA 1 T8

Table 4662 - Segments of interest Segment Name

HUMEB2CR2 PEA 1 node 2

HUMEB2CR2 PEA 1 node 5

HUMEB2CR2 PEA 1 node 7

HUMEB2CR2 PEA 1 node 8

HUMEB2CR2 PEA 1 node 14

HUMEB2CR2 PEA 1 node 16

HUMEB2CR2 PEA 1 node 23

HUMEB2CR2 PEA 1 node 31

HUMEB2CR2_ PEA 1 node 33

HUMEB2CR2 PEA 1 node 35

HUMEB2CR2 PEA 1 node 37

HUMEB2CR2 PEA 1 node 43

HUMEB2CR2 PEA 1 node 47

HUMEB2CR2 PEA 1 node 10

HUMEB2CR2 PEA 1 node 12

HUMEB2CR2 PEA 1 node 18

HUMEB2CR2 PEA 1 node 21

HUMEB2CR2 PEA 1 node 27

HUMEB2CR2 PEA 1 node 29

HUMEB2CR2 PEA 1 node 32

HUMEB2CR2 PEA 1 node 39

HUMEB2CR2 PEA 1 node 41

HUMEB2CR2 PEA 1 node 44

Table 4663 - Proteins of interest

These sequences are variants of the known protein Complement receptor type 2 precursor (SwissProt accession identifier CR2_HUMAN; known also according to the synonyms Cr2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD21 antigen), referred to herein as the previously known protein.

Protein Complement receptor type 2 precursor is known or believed to have the following function(s): Receptor for complement C3Dd and for the Epstein-Barr virus on human B-cells and T-cells. Participates in B lymphocytes activation. The sequence for protein Complement receptor type 2 precursor is given at the end of the application, as "Complement receptor type 2 precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4664.

Table 4664 - Amino acid mutations for Known Protein

Protein Complement receptor type 2 precursor localization is believed to be Type I membrane protein.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: immune response; complement activation, classical pathway, which are annotation(s) related to Biological Process; complement receptor; transmembrane receptor, which are annotation(s) related to Molecular Function; and plasma membrane; integral membrane protein, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster HUMEB2CR2 features 23 segment(s), which were listed in Table

4662 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMEB2CR2_PEA_l_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4. Table 4665 below describes the starting and ending position of this segment on each transcript.

Table 4665 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMEB2CR2_PEA_1 J^>5.

Segment cluster HUMEB2CR2_PEA_l_node_5 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4. Table 4666 below describes the starting and ending position of this segment on each transcript.

Table 4666 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5.

Segment cluster HUMEB2CR2_PEA_l_node_7 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T5. Table 4667 below describes the starting and ending position of this segment on each transcript.

Table 4667 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMEB2CR2_PEA_1_P6.

Segment cluster HUMEB2CR2_PEA_l_node_8 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4668 below describes the starting and ending position of this segment on each transcript.

Table 4668 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_14 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4669 below describes the starting and ending position of this segment on each transcript. Table 4669 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6. Segment cluster HUMEB2CR2_PEA_l_node_16 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4670 below describes the starting and ending position of this segment on each transcript.

Table 4670 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1 JP5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_23 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4671 below describes the starting and ending position of this segment on each transcript.

Table 4671 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_31 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4672 below describes the starting and ending position of this segment on each transcript.

Table 4672 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_j33 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4673 below describes the starting and ending position of this segment on each transcript.

Table 4673 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2JPEA_l_node_35 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and

HUMEB2CR2_PEA_1_T5. Table 4674 below describes the starting and ending position of this segment on each transcript.

Table 4674 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2_PEA_1_P6.

Segment cluster HUMEB2CR2_PEA_l_node_37 according to the present invention is supported by 22 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4675 below describes the starting and ending positron of this segment on each transcript. Table 4675 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_43 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T8. Table 4676 below describes the starting and ending position of this segment on each transcript.

Table 4676 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster HUMEB2CR2_PEA_l_node_47 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2JPEA_1_T4, HUMEB2CR2_PEA_1_T5 and HUMEB2CR2_PEA_1_T8. Table 4677 below describes the starting and ending position of this segment on each transcript.

Table 4677 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2_PEA_1_P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMEB2CR2_PEA_l_node_10 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4678 below describes the starting and ending position of this segment on each transcript.

Table 4678 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6. Segment cluster HUMEB2CR2_PEA_l_node_12 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4679 below describes the starting and ending position of this segment on each transcript.

Table 4679 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_l 8 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4680 below describes the starting and ending position of this segment on each transcript.

Table 4680 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_21 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4681 below describes the starting and ending position of this segment on each transcript.

Table 4681 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_27 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4682 below describes the starting and ending position of this segment on each transcript.

Table 4682 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_l_node_29 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and

HUMEB2CR2_PEA_1_T5. Table 4683 below describes the starting and ending position of this segment on each transcript.

Table 4683 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2JPEA_1JP5 and HUMEB2CR2JPEAJ P6.

Segment cluster HUMEB2CR2_PEA_l_node_32 according to the present invention can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and

HUMEB2CR2_PEA_1_T5. Table 4684 below describes the starting and ending position of this segment on each transcript.

Table 4684 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

Segment cluster HUMEB2CR2_PEA_ l_node_39 according to the present invention can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1 _T5. Table 4685 below describes the starting and ending position of this segment on each transcript.

Table 4685 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6. Segment cluster HUMEB2CR2_PEA_1 jαode_41 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4 and HUMEB2CR2_PEA_1_T5. Table 4686 below describes the starting and ending position of this segment on each transcript.

Table 4686 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2_JPEA_1_P6.

Segment cluster HUMEB2CR2_PEA_l_node_44 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMEB2CR2_PEA_1_T4, HUMEB2CR2JPEA_1_T5 and HUMEB2CR2_PEA_1_T8. Table 4687 below describes the starting and ending position of this segment on each transcript.

Table 4687 - Segment location on transcripts

This segment can be found in the following protein(s): HUMEB2CR2_PEA_1_P5 and HUMEB2CR2 PEA 1 P6.

DESCRIPTION FOR CLUSTER HUMFXI Cluster HUMFXI features 17 transcript(s) and 28 segment(s) of interest, the names for which are given in Tables 4688 and 4689, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4690.

Table 4688 - Transcripts of interest

Transcript Name

HUMFXI PEA 1 TO

HUMFXI PEA 1 T2

HUMFXI PEA 1 T3

HUMFXI PEA 1 T5

HUMFXI PEA 1 T6

HUMFXI PEA 1 T7

HUMFXI PEA 1 T8

HUMFXI PEA 1 T9

HUMFXI PEA 1 TlO

HUMFXI PEA 1 TI l

HUMFXI PEA 1 T12

HUMFXI PEA 1 T14

HUMFXI PEA 1 T15

HUMFXI PEA 1 T16

HUMFXI PEA 1 T17

HUMFXI PEA 1 T18

HUMFXI PEA 1 T19

Table 4689 - Segments of interest

Segment Name

HUMFXI PEA 1 node 0

HUMFXI PEA 1 node 3

HUMFXI PEA 1 node 7

HUMFXI PEA 1 node 12

HUMFXI PEA 1 node 13

HUMFXI PEA 1 node 17

HUMFXI PEA 1 node 26

HUMFXI PEA 1 node 30

HUMFXI PEA 1 node 32

HUMFXI PEA 1 node 38

HUMFXI PEA 1 node 40

HUMFXI PEA 1 node 41 HUMFXl PEA 1 node 43

HUMFXI PEA 1 node 1

HUMFXI PEA 1 node 2

HUMFXI PEA 1 node 5

HUMFXI PEA 1 node 10

HUMFXI PEA 1 node 15

HUMFXI PEA 1 node 19

HUMFXI PEA 1 node 21

HUMFXI PEA 1 node 22

HUMFXI PEA 1 node 23

HUMFXI PEA 1 node 24

HUMFXI PEA 1 node 27

HUMFXI PEA 1 node 28

HUMFXI PEA 1 node 34

HUMFXI PEA 1 node 36

HUMFXI PEA 1 node 37

Table 4690 - Proteins of interest

These sequences are variants of the known protein Coagulation factor XI precursor (SwissProt accession identifier FAl IJHUMAN; known also according to the synonyms EC 3.4.21.27; Plasma thromboplastin antecedent; PTA; FXI), referred to herein as the previously known protein.

Protein Coagulation factor XI precursor is known or believed to have the following function(s): Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. The sequence for protein Coagulation factor XI precursor is given at the end of the application, as "Coagulation factor XI precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4691.

Table 4691 - Amino acid mutations for Known Protein

Protein Coagulation factor XI precursor localization is believed to be Secreted.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: proteolysis and peptidolysis; blood coagulation, which are annotation(s) related to Biological Process; blood coagulation factor IX; blood coagulation factor XI; chymotrypsin; trypsin; hydrolase, which are annotation(s) related to Molecular Function; and extracellular; membrane, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi .nlm .nih. gov/proj ects/LocusLink/> .

As noted above, cluster HUMFXI features 28 segment(s), which were listed in Table 4689 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMFXIJPE A_l_node_0 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_TO, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXIJPEA _1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T15, HUMFXI_PEA_1_T18 and HUMFXI_PEA_l_T19. Table 4692 below describes the starting and ending position of this segment on each transcript. Table 4692 - Segment location on transcripts

38

2636

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1__P1, HUMFXI_PEA_1_P2, HUMFXI_PEA_1_P17, HUMFXI_PEA_1_P4, HUMFXIJPEAJJP18, HUMFXI JPEA_1J^>6, HUMFXIJPEAJJP7, HUMFXI JPEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11, HUMFXI_PEA_1_P12 and HUMFXI PEA 1 P15.

Segment cluster HUMFXI_PEA_l_node_3 according to the present invention is supported by 1 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_T19. Table 4693 below describes the starting and ending position of this segment on each transcript.

Table 4693 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HUMFXI_PEA_l_node_7 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXIJPEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T15 and HUMFXI_PEA_1_T18. Table 4694 below describes the starting and ending position of this segment on each transcript.

Table 4694 - Segment location on transcripts

This segment can be found in ths following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1_P2, HUMFXI_PEA_1_P17, HUMFXIJPE A_1_P4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11, HUMFXI_PEA_1_P12 and HUMFXI_PEA_1_P15.

Segment cluster HUMFXI_PEA_l_node_12 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T5 , HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T15 and HUMFXI_PEA_1_T18. Table 4695 below describes the starting and ending position of this segment on each transcript. Table 4695 - Segment location on transcripts

This segment can be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXIJPEAJ J^>2, HUMFXIJPEA_1_P4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1JP7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11, HUMFXI PEA 1 P12 and HUMFXI PEA 1 Pl 5.

Segment cluster HUMFXI_PEA_l_node_13 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_T18. Table 4696 below describes the starting and ending position of this segment on each transcript.

Table 4696 - Segment location on transcripts

This segment can be found in the following protein(s): HUMFXI_PEA_1_P15.

Segment cluster HUMFXI_PEA_l_node_17 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T14 and HUMFXI_PEA_1_T15. Table 4697 below describes the starting and ending position of this segment on each transcript.

Table 4697 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P17. This segment can also be found in the following protein(s): HUMFXIJPEAJ Pl, HUMFXI_PEA_1JP4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXIJPEA_1J^>7, HUMFXI_PEA_1_P11 and HUMFXI_PEA_1_P12, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_26 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_T16. Table 4698 below describes the starting and ending position of this segment on each transcript.

Table 4698 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P13.

Segment cluster HUMFXI_PEA_l_node_30 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7₅ HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14 and HUMFXI_PEA_1_T16. Table 4699 below describes the starting and ending position of this segment on each transcript.

Table 4699 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P17, HUMFXI_PEA_1_P4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P8 and HUMFXI_PEA_l_P19. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1_P2, HUMFXI_PEA_1_P7, HUMFXI_PEA_1_P11 and HUMFXI_PEA_1_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_32 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXIJPEAJ_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEAJ_T12 and HUMFXI_PEA_1_T16. Table 4700 below describes the starting and ending position of this segment on each transcript.

Table 4700 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1 JP17, HUMFXI_PEA_1_P4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXI_PEA_ 1_P8 and HUMFXI_PEA_1_P19. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1JP2, HUMFXI_PEA_1_P7 and HUMFXI_PEA_1_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_38 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0,

HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXIJPEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14, HUMFXIJPEA_1_T16 and HUMFXI_PEA_1_T17. Table 4701 below describes the starting and ending position of this segment on each transcript. Table 4701 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P17, HUMFXI_PEA_1_P4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P8 and HUMFXI_PEA_1_P19. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1_P2, HUMFXI_PEA_1_P7, HUMFXIJPEA_1_P11, HUMFXI_PEA_1_P13 and HUMFXI_PEA_1_P14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_40 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1 _TO, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T16 and HUMFXIJPEA_1_T17. Table 4702 below describes the starting and ending position of this segment on each transcript.

Table 4702 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P17, HUMFXI_PEA_1_P4, HUMFXI_PEA_1JP18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P19 and HUMFXI_PEA_1_P11. This segment can also be found in the following protein(s): HUMFXI_PEA_1JP1, HUMFXI_PEA_1_P2, HUMFXI_PEA_1JP7, HUMFXI_PEA_1_P13 and HUMFXI_PEA_1_P14, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_41 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXIJPEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14,

HUMFXI_PEA_1_T16 and HUMFXI_PEA_1_T17. Table 4703 below describes the starting and ending position of this segment on each transcript.

Table 4703 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P1, HUMFXI__PEA_1_P2, HUMFXI_PEA_1 J^>17, HUMFXI_PEA_1JP4, HUMFXI_PEA_1_P18, HUMFXΪ_PEA_1_P6, HUMFXI_PEA_1_P7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11, HUMFXI_PEA_1_P13 and HUMFXI PEA 1 P 14.

Segment cluster HUMFXI_PEA_l_node_43 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0,

HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_ 1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXIJPEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T16 and HUMFXI_PEA_1_T17. Table 4704 below describes the starting and ending position of this segment on each transcript.

Table 4704 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P1, HUMFXIJPEAJJP2, HUMFXI PEAJJP17, HUMFXI JPEA_1_P4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1JP7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P 19, HUMFXI_PEA_1_P 11 , HUMFXI_PEA_1_P 13 and HUMFXI PEA 1 P14.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMFXI_PEA_l_node_l according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_TO,

HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXMP EA_1_T8, HUMFXI_PEA_1_T9, HUMFXI JPEA_l_T10, HUMFXI_PEAJ_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T15, HUMFXI_PEA_1_T18 and HUMFXI_PEA_1_T19. Table 4705 below describes the starting and ending position of this segment on each transcript.

Table 4705 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P1, HUMFXIJPEA_1_P2, HUMFXI JPEA_1_P17, HUMFXI_PEA_1_P4, HUMFXI__PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11, HUMFXI_PEA_1_P12 and HUMFXI PEA 1 P15.

Segment cluster HUMFXIJPEA_l_node_2 according to the present invention can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI JPEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T15, HUMFXIJPEA_1_T18 and HUMFXI_PEA_1_T19. Table 4706 below describes the starting and ending position of this segment on each transcript. Table 4706 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXIJPEAJJP17, HUMFXI_PEA_1_P18 and HUMFXI_PEA_1_P19. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXIJPEA 1JP2, HUMFXI_PEA_1_P4, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P7, HUMFXIJPEAJJP8, HUMFXI_PEA_1_P11, HUMFXI_PEA_1J^>12 and HUMFXI_PEA_1_P15, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_5 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXIJPEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI JPEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1 _T12, HUMFXI_PEA_1_T14,

HUMFXIJPEA_1_T15 and HUMFXI_PEA_1_T18. Table 4707 below describes the starting and ending position of this segment on each transcript.

Table 4707 - Segment location on transcripts

This segment can be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1_P2, HUMFXI_PEA_1_P17, HUMFXI_PEA_1_P4, HUMFXI_PEAJ_P18, HUMFXIJPEAJJP6, HUMFXI_PEA_1_P7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11, HUMFXIJPEAJJP12 and HUMFXI_PEA_1_P15.

Segment cluster HUMFXI_PEA_l_node_10 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_ 1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXIJPEAJ_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T15 and HUMFXI_PEA_1_T18. Table 4708 below describes the starting and ending position of this segment on each transcript. Table 4708 - Segment location on transcripts

This segment can be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1_P2, HUMFXI_PEA_1JP17, HUMFXI_PEA_1_P4, HUMFXIJPEAJJP18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1J^>7, HUMFXIJPEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11, HUMFXI_PEA_1_P12 and HUMFXI_PEA_1_P15.

Segment cluster HUMFXI_PEA_l_node_15 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T14 and HUMFXI_PEA_1_T15. Table 4709 below describes the starting and ending position of this segment on each transcript.

Table 4709 - Segment location on transcripts

This segment can be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1_P17, HUMFXI_PEA_1_P4, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P7, HUMFXI PEA 1 PI l and HUMFXI PEA 1 P12. 02438

2650

Segment cluster HUMFXI_PEA_l_node_19 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_TO, HUMFXI_PEAJ_T2, HUMFXI_PEAJ_T3, HUMFXIJPEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI__PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14 and HUMFXI_PEA_1_T15. Table 4710 below describes the starting and ending position of this segment on each transcript.

Table 4710 - Segment location on transcripts

This segment can be found in both coding and noi> coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P17 and HUMFXI_PEA_1_P18. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI JPEA_1_P2, HUMFXI_PEA_1_P4, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11 and HUMFXI_PEA_1_P12, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_21 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_TO, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXIJPEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXIJPEAJ_Tl l, HUMFXI_PEA_1_T14 and HUMFXIJPE AJ_Tl 5. Table 4711 below describes the starting and ending position of this segment on each transcript.

Table 4711 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcripts) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1JP17 and HUMFXI_PEA_1_P18. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1_P2, HUMFXI JPEA_1_P4, HUMFXI JPEA_1JP7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1JP11 and HUMFXI_PEA_1 JP12, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_ l_node_22 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14 and HUMFXI_PEA_1_T15. Table 4712 below describes the starting and ending position of this segment on each transcript.

Table 4712 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXIJPEA_1_P17 and HUMFXIJPEAJJP18. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1_P2, HUMFXI_PEA_1_P4, HUMFXI_PEA_1_JP6, HUMFXI_PEA_1_P7, HUMFXI_PEA_1_P8, HUMFXI_PEA_1_P19, HUMFXI_PEA_1_P11 and HUMFXI_PEA_1_P12, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_23 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T8, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11 and HUMFXI_PEA_1_T12. Table 4713 below describes the starting and ending position of this segment on each transcript.

Table 4713 - Segment location on transcripts

This segment can be found in the following protein(s): HUMFXI_PEA_1_P4, HUMFXI_PEA_1_P6, HUMFXIJPEAJJP8 and HUMFXI_PEA_1_P19.

Segment cluster HUMFXI_PEA_l_node_24 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T0, HUMFXI_PEA_1_T2, HUMFXI_PEA_1_T3, HUMFXI_PEA_1__T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA__1_T14 and HUMFXI_PEA_1_T15. Table 4714 below describes the starting and ending position of this segment on each transcript.

Table 4714 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXIJPEAJJP17, HUMFXI_PEA_1_P4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXIJPEAJJP8 and HUMFXI_PEA_1_P19. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXI_PEA_1 JP2, HUMFXI_PEA_1_P7, HUMFXI_PEA_1JP11 and HUMFXI_PEA_1_P12, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXI_PEA_l_node_27 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_l_T10, HUMFXI_PEA_1_T15 and HUMFXI_PEA_1_T16. Table 4715 below describes the starting and ending position of this segment on each transcript.

Table 4715 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXIJPEA_1_P4. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P12 and HUMFXI_PEA_1_P13, since it is in the coding region for the corresponding transcript.

Segment cluster HUMFXIJPEA_l_node_28 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_T15. Table 4716 below describes the starting and ending position of this segment on each transcript.

Table 4716 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXIJΕAJ J?12.

Segment cluster HUMFXI_PEA_l_node_34 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMFXIJPE A J _TO, HUMFXIJPEAJ _T2, HUMFXIJΕAJ _T3, HUMFXI_PEA_1_T5, HUMFXIJPEAJ _T6, HUMFXI J⁵EAJ _T7, HUMFXI_PEA_1_T8, HUMFXI J¹EA J _TlO, HUMFXI J¹E A J _T 11 and HUMFXI JPEAJ _T12. Table 4717 below describes the starting and ending position of this segment on each transcript.

Table 4717 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P17, HUMFXI_PEA_1_P4, HUMFXIJ^>EAJ J^>18, HUMFXI_PEA_1_P6, HUMFXIJPEAJ J^>8 and HUMFXIJΕAJ J^> 19. This segment can also be found in the following protein(s): HUMFXI JPEA J JPl and HUMFXIJPEAJ JP2, since it is in the coding region for the corresponding transcript. Segment cluster HUMFXI_PEA_l_node_36 according to the present invention is supported by 1 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): HUMFXI_PEA_1_T17. Table 4718 below describes the starting and ending position of this segment on each transcript.

Table 4718 - Segment location on transcripts

This segment can be found in the following protein(s): HUMFXI_PEA_1_P14.

Segment cluster HUMFXI_PEA_1 jiode_37 according to the present invention can be found in the following transcript(s): HUMFXI_PEA_1_TO, HUMFXI_PEA_1_T2,

HUMFXI_PEA_1_T3, HUMFXI_PEA_1_T5, HUMFXI_PEA_1_T6, HUMFXI_PEA_1_T7, HUMFXI_PEA_1_T8, HUMFXI_PEA_1_T9, HUMFXI_PEA_l_T10, HUMFXIJPEA_1_T11, HUMFXI_PEA_1_T12, HUMFXI_PEA_1_T14, HUMFXI_PEA_1_T16 and HUMFXI_PEA_1_T17. Table 4719 below describes the starting and ending position of this segment on each transcript.

Table 4719 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMFXI_PEA_1_P17, HUMFXIJPEA_1_P4, HUMFXI_PEA_1_P18, HUMFXI_PEA_1_P6, HUMFXI_PEA_1_P8 and HUMFXI_PEA_1_P19. This segment can also be found in the following protein(s): HUMFXI_PEA_1_P1, HUMFXIJPEA_1_P2, HUMFXI_PEA_1_P7, HUMFXI_PEA_1_P11, HUMFXIJPEAJJP13 and HUMFXI_PEA_1_P14, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER HUMHOXAB

Cluster HUMHOXAB features 1 transcript(s) and 5 segment(s) of interest, the names for which are given in Tables 4720 and 4721, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4722.

Table 4720 ~ Transcripts of interest

Transcript Name

HUMHOXAB PEA 1 T₄

Table 4721 - Segments of interest

Segment Name

HUMHOXAB PEA 1 node 5

HUMHOXAB PEA 1 node 12

HUMHOXAB PEA 1 node 14

HUMHOXAB PEA 1 node 13

HUMHOXAB PEA 1 node 15

Table 4722 - Proteins of interest

These sequences are variants of the known protein Homeobox protein Hox-B7 (SwissProt accession identifier HXB7JHUMAN; known also according to the synonyms Hox-2C; HHO.C1), referred to herein as the previously known protein.

Protein Homeobox protein Hox-B7 is known or believed to have the following function(s): Sequence- specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. The sequence for protein Homeobox protein Hox-B7 is given at the end of the application, as "Homeobox protein Hox-B7 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4723. Table 4723 -Amino acid mutations for Known Protein

Protein Homeobox protein Hox-B7 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription regulation; developmental processes, which are annotation(s) related to Biological Process; transcription factor, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from ^ttp^/www.ncbi.nrm.nih.gov/projects/LocusLinl^. 38

2659

Cluster HUMHOXAB can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of the Figure 119 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 119 and Table 4724. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 4724 - Normal tissue distribution

Table 4725 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 4726.

Table 4726 - Oligonucleotides related to this cluster

As noted above, cluster HUMHOXAB features 5 segment(s), which were listed in Table 4721 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster HUMHOXAB_PEA_l_node_5 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMHOXAB_PEA_1_T4. Table 4727 below describes the starting and ending position of this segment on each transcript.

Table 4727 - Segment location on transcripts

This segment can be found in the following protein(s): HUMHOXAB_PEA_1_P3.

Segment cluster HUMHOXAB_PEA_l_node_12 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMHOXAB_PEA_1_T4. Table 4728 below describes the starting and ending position of this segment on each transcript.

Table 4728 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMH0XAB_PEA_l_P3.

Segment cluster HUMHOXAB_PEA_l_node_14 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMHOXAB_PEA_1_T4. Table 4729 below describes the starting and ending position of this segment on each transcript.

Table 4729 - Segment location on transcripts

This segment can be found in a non-codmg region of transcript(s) that are related to the following protein(s): HUMHOXAB_PEA_1_P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMHOXAB_PEA_l_node_13 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMHOXAB_PEA_1_T4. Table 4730 below describes the starting and ending position of this segment on each transcript.

Table 4730 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMHOXAB_PEA_1_P3.

Segment cluster HUMHOXABJPEA_l_node_15 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMHOXAB_PEA_1_T4. Table 4731 below describes the starting and ending position of this segment on each transcript.

Table 4731 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMHOXAB_PEA_1_P3. DESCRIPTION FOR CLUSTER HUMKERMII

Cluster HUMKERMII features 7 transcript(s) and 50 segment(s) of interest, the names for which are given in Tables 4732 and 4733, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4734. Table 4732 - Transcripts of interest

Transcript Name

HUMKERMII T16

HUMKERMII T18

HUMKERMII T21

HUMKERMII T22

HUMKERMII T27

HUMKERMII T29

HUMKERMII T35

Table 4733 - Segments of interest

Segment Name

HUMKERMII node 2

HUMKERMΠ node 6

HUMKERMII node 15

HUMKERMII node 21

HUMKERMII node 26

HUMKERMII node 28

HUMKERMII node 69

HUMKERMII node 71

HUMKERMII node 0

HUMKERMII node 4

HUMKERMΠ node 7

HUMKERMII node 8

HUMKERMΠ node 9

HUMKERMII node 10

HUMKERMII node 11

HUMKERMII node 12

HUMKERMII node 13 HUMKERMII node 16

HUMKERMII node 17

HUMKERMII node 18

HUMKERMII node 19

HUMKERMII node 20

HUMKERMII node 22

HUMKERMII node 23

HUMKERMII node 24

HUMKERMII node 25

HUMKERMII_ node_ 29

HUMKERMII node 30

HUMKERMII node 31

HUMKERMII node 34

HUMKERMII node 35

HUMKERMII node 36

HUMKERMII node 37

HUMKERMII node 38

HUMKERMII node 40

HUMKERMII node 41

HUMKERMII node 43

HUMKERMII node 44

HUMKERMII node 51

HUMKERMII node 52

HUMKERMII node 53

HUMKERMII node 54

HUMKERMII_ node _55

HUMKERMII node 56

HUMKERMII node 57

HUMKERMII node 58

HUMKERMII node 62

HUMKERMII node 66

HUMKERMII node 67

HUMKERMII node 68

Table 4734 - Proteins of interest

These sequences are variants of the known protein Keratin, type II cytoskeletal 7 (SwissProt accession identifier K2C7_HUMAN; known also according to the synonyms Cytokeratin 7; K7; CK 7; Sarcolectin), referred to herein as the previously known protein.

The sequence for protein Keratin, type II cytoskeletal 7 is given at the end of the application, as "Keratin, type II cytoskeletal 7 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4735.

Table 4735 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cytoskeleton organization and biogenesis, which are annotation(s) related to Biological Process; structural protein, which are annotation(s) related to Molecular Function; and intermediate filament, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>. Cluster HUMKERMII can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The teπn "number" in the left hand column of the table and the numbers on the y-axis of Figure 120 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 120 and Table 4736. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: transitional cell carcinoma, a mixture of malignant tumors from different tissues, ovarian carcinoma and pancreas carcinoma.

Table 4736 - Normal tissue distribution

Table 4737 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMKERMII features 50 segment(s), which were listed in Table 4733 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMKERMII_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T21. Table 4738 below describes the starting and ending position of this segment on each transcript.

Table 4738 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII-P 15. Segment cluster HUMKERMII_node_6 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4739 below describes the starting and ending position of this segment on each transcript.

Table 4739 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P12, HUMKERMII_P16, HUMKERMII_P20 and HUMKERMII P22.

Segment cluster HUMKERMII_node_15 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T18. Table 4740 below describes the starting and ending position of this segment on each transcript.

Table 4740 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERMIIJP5.

Segment cluster HUMKERMII_node_21 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T29. Table 4741 below describes the starting and ending position of this segment on each transcript. Table 4741 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P22.

Segment cluster HUMKERMII_node_26 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T27 and HUMKERMII _T29. Table 4742 below describes the starting and ending position of this segment on each transcript.

Table 4742 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P20 and HUMKERMII P22.

Segment cluster HUMKERMII_node_28 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T35. Table 4743 below describes the starting and ending position of this segment on each transcript.

Table 4743 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P25. Segment cluster HUMKERMII_node_69 according to the present invention is supported by 154 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): HUMKERMII_T18, HUMKERMII_T21 , HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4744 below describes the starting and ending position of this segment on each transcript.

Table 4744 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERMIIJ^, HUMKERMII_P15, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_71 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16 and HUMKERMII_T22. Table 4745 below describes the starting and ending position of this segment on each transcript.

Table 4745 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12 and HUMKERMII P16. According to an optional embodiment of the present invention, sho rt segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMKERMII__node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T21. Table 4746 below describes the starting and ending position of this segment on each transcript.

Table 4746 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P15.

Segment cluster HUMKERMII_node_4 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4747 below describes the starting and ending position of this segment on each transcript.

Table 4747 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P12, HUMKERMII_P16, HUMKERMII_P20 and HUMKERMII P22. Segment cluster HUMKERMIIjαodeJ7 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII _T29. Table 4748 below describes the starting and ending position of this segment on each transcript.

Table 4748 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMIIJP16 and HUMKERMII JP20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_8 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII _T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4749 below describes the starting and ending position of this segment on each transcript.

Table 4749 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_9 according to the present invention is supported by

57 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4750 below describes the starting and ending position of this segment on each transcript. Table 4750 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_10 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T22,

HUMKERMII_T27 and HUMKERMII_T29. Table 4751 below describes the starting and ending position of this segment on each transcript.

Table 4751 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMIIjnode l 1 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4752 below describes the starting and ending position of this segment on each transcript.

Table 4752 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_12 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4753 below describes the starting and ending position of this segment on each transcript. Table 4753 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMIIJP22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_13 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4754 below describes the starting and ending position of this segment on each transcript.

Table 4754 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript. Segment cluster HUMKERMII_node_l 6 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII _T29. Table 4755 below describes the starting and ending position of this segment on each transcript.

Table 4755 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII JP5 and HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMIIJP12, HUMKERMII_P15, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_17 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4756 below describes the starting and ending position of this segment on each transcript.

Table 4756 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P5 and HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P15, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_l 8 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII T18, HLJMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4757 below describes the starting and ending position of this segment on each transcript.

Table 4757 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P5 and HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P15, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_19 according to the present invention is supported by 136 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4758 below describes the starting and ending position of this segment on each transcript.

Table 4758 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P5 and HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P15, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMKERMII_node_20 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMIIjm, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4759 below describes the starting and ending position of this segment on each transcript.

Table 4759 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMKERMII_P22. This segment can also be found in the following protein(s): HUMKERMIIJP12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16 and HUMKERMII_P20, since it is in the coding region for the corresponding transcript. Segment cluster HUMKERMII_node_22 according to the present invention is supported by 3 libraries. The number of libraπes was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T29. Table 4760 below describes the starting and ending position of this segment on each transcript.

Table 4760 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P22.

Segment cluster HUMKERMII_node_23 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4761 below describes the starting and ending position of this segment on each transcript. Table 4761 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20 and HUMKERMπ_P22.

Segment cluster HUMKERMII_node_24 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMπ_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27 and HUMKERMII_T29. Table 4762 below describes the starting and ending position of this segment on each transcript.

Table 4762 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12,

HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII J?20 and HUMKERMII P22.

Segment cluster HUMKERMII_node_25 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII _T27 and HUMKERMII T29. Table 4763 below describes the starting and ending position of this segment on each transcript.

Table 4763 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20 and HUMKERMII P22. Segment cluster HUMKERMII_node_29 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4764 below describes the starting and ending position of this segment on each transcript.

Table 4764 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_30 according to the present invention is supported by 166 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4765 below describes the starting and ending position of this segment on each transcript.

Table 4765 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_31 according to the present invention is supported by 161 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII-T 16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4766 below describes the starting and ending position of this segment on each transcript.

Table 4766 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMπ_P15, HUMKERMII_P16, HUMKERMII_P2O, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_34 according to the present invention is supported by 178 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4767 below describes the starting and ending position of this segment on each transcript.

Table 4767 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII-P 12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMIIJP20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_35 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4768 below describes the starting and ending position of this segment on each transcript. Table 4768 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMIIJ?5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII_P22 and HUMKERMII_P25.

Segment cluster HUMKERMII_node_36 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4769 below describes the starting and ending position of this segment on each transcript.

Table 4769 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12,

HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_37 according to the present invention is supported by 166 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4770 below describes the starting and ending position of this segment on each transcript. Table 4770 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMIIJP20, HUMKERMII_P22 and HUMKERMII_P25.

Segment cluster HUMKERMII_node_38 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII T29 and HUMKERMII_T35. Table 4771 below describes the starting and ending position of this segment on each transcript.

Table 4771 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMIIJP20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_40 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4772 below describes the starting and ending position of this segment on each transcript.

Table 4772 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_41 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4773 below describes the starting and ending position of this segment on each transcript. Table 4773 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMIIJP15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII_P22 and HUMKERMII_P25.

Segment cluster HUMKERMII_node_43 according to the present invention is supported by 179 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4774 below describes the starting and ending position of this segment on each transcript.

Table 4774 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMIIJP16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_44 according to the present invention is supported by 154 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMIIJB 5. Table 4775 below describes the starting and ending position of this segment on each transcript.

Table 4775 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMΠ_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25. Segment cluster HUMKERMII_node_51 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4776 below describes the starting and ending position of this segment on each transcript.

Table 4776 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMIIJP5, HUMKERMII_P15, HUMKERMIIJP16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII_P25.

Segment cluster HUMKERMII_node_52 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMIIjm, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4777 below describes the starting and ending position of this segment on each transcript. Table 4777 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMIIJP12, HUMKERMII_P5, HUMKERMIIJP15, HUMKERMIIJP16, HUMKERMII_P20, HUMKERMII_P22 and HUMKERMII_P25.

Segment cluster HUMKERMII_node_53 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMI1_T35. Table 4778 below describes the starting and ending position of this segment on each transcript.

Table 4778 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII__P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_54 according to the present invention is supported by 160 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4779 below describes the starting and ending position of this segment on each transcript.

Table 4779 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMIIJP22 and HUMKERMII_JP25.

Segment cluster HUMKERMII_node_55 according to the present invention is supported by 179 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4780 below describes the starting and ending position of this segment on each transcript.

Table 4780 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_56 according to the present invention can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4781 below describes the starting and ending position of this segment on each transcript.

Table 4781 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12,

HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_57 according to the present invention can be found in the following transcript(s): HUMKERMII T16, HUMKERMIΪ_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4782 below describes the starting and ending position of this segment on each transcript.

Table 4782 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25. Segment cluster HUMKERMII_node_58 according to the present invention is supported by 181 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T22, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4783 below describes the starting and ending position of this segment on each transcript.

Table 4783 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P16, HUMKERMII_P20, HUMKERMII P22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_62 according to the present invention is supported by 184 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T16, HUMKERMII_T18,

HUMKERMII_T21, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4784 below describes the starting and ending position of this segment on each transcript.

Table 4784 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P12, HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P20, HUMKERMIIJP22 and HUMKERMII P25.

Segment cluster HUMKERMII_node_66 according to the present invention is supported by 192 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4785 below describes the starting and ending position of this segment on each transcript.

Table 4785 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMIIJP5, HUMKERMII_P15, HUMKERMH_P20, HUMKERMII_P22 and HUMKERMII_P25.

Segment cluster HUMKERMII_node_67 according to the present invention is supported by 199 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T18, HUMKERMII_T21, HUMKERMII_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4786 below describes the starting and ending position of this segment on each transcript.

Table 4786 - Segment location on transcripts

HUMKERMII T35 1473 1536

This segment can be found in the following protein(s): HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P20, HUMKERMII_P22 and HUMKERMII_P25.

Segment cluster HUMKERMII_node_68 according to the present invention is supported by 191 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMKERMII_T18, HUMKERMII_T21, HUMKERMπ_T27, HUMKERMII_T29 and HUMKERMII_T35. Table 4787 below describes the starting and ending position of this segment on each transcript.

Table 4787 - Segment location on transcripts

This segment can be found in the following protein(s): HUMKERMII_P5, HUMKERMII_P15, HUMKERMII_P20, HUMKERMII_P22 and HUMKERMII_P25.

DESCRIPTION FOR CLUSTER HUMMHGM

Cluster HUMMHGM features 16 transcript(s) and 104 segment(s) of interest, the names for which are given in Tables 4788 and 4789, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4790.

Table 4788 - Transcripts of interest

Transcript Name HUMMHGM T8

HUMMHGM T12

HUMMHGM T13

HUMMHGM T15

HUMMHGM T17

HUMMHGM T18

HUMMHGM T20

HUMMHGM T28

HUMMHGM T29

HUMMHGM_ _T35

HUMMHGM T36

HUMMHGM T40

HUMMHGM T43

HUMMHGM T44

HUMMHGM T89

HUMMHGM T90

Table 4789 - Segments of interest

Segment Name

HUMMHGM node 1

HUMMHGM node 7

HUMMHGM node 9

HUMMHGM node 13

HUMMHGM node 31

HUMMHGM node 36

HUMMHGM node 41

HUMMHGM node 43

HUMMHGM node 44

HUMMHGM node 50

HUMMHGM node 57

HUMMHGM node 60

HUMMHGM node 63

HUMMHGM node_ _.69

HUMMHGM node 74

HUMMHGM node 113

HUMMHGM node 2

HUMMHGM node 3

HUMMHGM node 4

HUMMHGM node 5

HUMMHGM node 6

HUMMHGM node 8

HUMMHGM node 18

HUMMHGM node 20 HUMMHGM node 21

HUMMHGM node 22

HUMMHGM node 23

HUMMHGM node 24

HUMMHGM node 25

HUMMHGM node 26

HUMMHGM node 27

HUMMHGM node 28

HUMMHGM node 29

HUMMHGM node 30

HUMMHGM node 32

HUMMHGM node 33

HUMMHGM node 34

HUMMHGM node 35

HUMMHGM node 37

HUMMHGM node 38

HUMMHGM node 39

HUMMHGM node 40

HUMMHGM node 42

HUMMHGM node 45

HUMMHGM node 46

HUMMHGM node 47

HUMMHGM node 48

HUMMHGM node 49

HUMMHGM node 51

HUMMHGM_ node _52

HUMMHGM node 53

HUMMHGM node 54

HUMMHGM node 55

HUMMHGM node 56

HUMMHGM node 58

HUMMHGM node 61

HUMMHGM node 62

HUMMHGM node 64

HUMMHGM node 65

HUMMHGM node 66

HUMMHGM node 67

HUMMHGM node 68

HUMMHGM node 70

HUMMHGM node 71

HUMMHGM node 72

HUMMHGM node 73

HUMMHGM node 75

HUMMHGM node 76 HUMMHGM node 77

HUMMHGM node 78

HUMMHGM node 79

HUMMHGM node 80

HUMMHGM node 81

HUMMHGM node 82

HUMMHGM node 83

HUMMHGM node 84

HUMMHGM node 85

HUMMHGM_ node _86

HUMMHGM node 87

HUMMHGM node 88

HUMMHGM node 89

HUMMHGM node 90

HUMMHGM node 91

HUMMHGM node 92

HUMMHGM node 93

HUMMHGM node 94

HUMMHGM node 95

HUMMHGM node 96

HUMMHGM node 97

HUMMHGM node 98

HUMMHGM node 99

HUMMHGM node 100

HUMMHGM node 101

HUMMHGM node 102

HUMMHGM node 103

HUMMHGM node 104

HUMMHGM node 105

HUMMHGM node 106

HUMMHGM node 107

HUMMHGM node 108

HUMMHGM node 109

HUMMHGM node 110

HUMMHGM node 111

HUMMHGM node 112

Table 4790 - Proteins of interest

These sequences are variants of the known protein HLA class II histocompatibility antigen, gamma chain (SwissProt accession identifier HG2A_HUMAN; known also according to the synonyms HLA-DR antigens associated invariant chain; Ia antigen- associated invariant chain; Ii; p33; CD74 antigen), referred to herein as the previously known protein.

Protein HLA class II histocompatibility antigen, gamma chain is known or believed to have the following function(s): Plays a critical role in MHC class II antigen processing by stabilizing peptide- free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. The sequence for protein HLA class II histocompatibility antigen, gamma chain is given at the end of the application, as "HLA class II histocompatibility antigen, gamma chain amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4791.

Table 4791 - Amino acid mutations for Known Protein

Protein HLA class II histocompatibility antigen, gamma chain localization is believed to be Type II membrane protein (Potential).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: immune response, which are annotations) related to Biological Process; chaperone, which are annotation(s) related to Molecular Function; and integral membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HUMMHGM can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The teπn "number" in the left hand column of the table and the numbers on the y-axis of Figure 120 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 121 and Table 4792. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors and pancreas carcinoma.

Table 4792 - Normal tissue distribution

Table 4793 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMMHGM features 104 segment(s), which were listed in Table 4789 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMMHGM_node_l according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM _T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43, HUMMHGM_T44, HUMMHGM_T89 and HUMMHGM_T90. Table 4794 below describes the starting and ending position of this segment on each transcript.

Table 4794 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7 and HUMMHGM_P63. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGMJP16, HUMMHGM_P21, HUMMHGM_P24, HUMMHGM_P26 and HUMMHGM_P64, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_nodeJ7 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T89 and HUMMHGM_T90. Table 4795 below describes the starting and ending position of this segment on each transcript.

Table 4795 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P63. This segment can also be found in the following protein(s): HUMMHGM_P64, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_9 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T89. Table 4796 below describes the starting and ending position of this segment on each transcript.

Table 4796 - Segment location on transcripts

This segment can be found in the following protein(s): HUMMHGM_P63.

Segment cluster HUMMHGM_node_13 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T90. Table 4797 below describes the starting and ending position of this segment on each transcript.

Table 4797 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P64.

Segment cluster HUMMHGM_node_31 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8 and HUMMHGM-Tl 3. Table 4798 below describes the starting and ending position of this segment on each transcript.

Table 4798 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_36 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T12, HUMMHGM_T13 and HUMMHGM_T18. Table 4799 below describes the starting and ending position of this segment on each transcript.

Table 4799 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P10. This segment can also be found in the following protein(s): HUMMHGM_P9, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_41 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T15, HUMMHGM_T18, HUMMHGM_T29 and HUMMHGM_T44. Table 4800 below describes the starting and ending position of this segment on each transcript.

Table 4800 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9. This segment can also be found in the following protein(s): HUMMHGM_P12, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_43 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T15, HUMMHGM-Tl 8, HUMMHGM_T29 and HUMMHGM_T44. Table 4801 below describes the starting and ending position of this segment on each transcript. Table 4801 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P12 and HUMMHGM_P9.

Segment cluster HUMMHGM_node_44 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T15, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T29 and HUMMHGM_T44. Table 4802 below describes the starting and ending position of this segment on each transcript.

Table 4802 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM-P 12 and HUMMHGM JP9. This segment can also be found in the following protein(s): HUMMHGMJP 16, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_50 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T36, HUMMHGM_T40 and HUMMHGM_T44. Table 4803 below describes the starting and ending position of this segment on each transcript.

Table 4803 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P12. This segment can also be found in the following protein(s): HUMMHGM_P24, since it is in the coding region for the corresponding transcript

Segment cluster HUMMHGM_node_57 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T40. Table 4804 below describes the starting and ending position of this segment on each transcript.

Table 4804 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM JP24.

Segment cluster HUMMHGM_node_60 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T40. Table 4805 below describes the starting and ending position of this segment on each transcript.

Table 4805 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P24.

Segment cluster HUMMHGM_node_63 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T40. Table 4806 below describes the starting and ending position of this segment on each transcript.

Table 4806 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P24.

Segment cluster HUMMHGM_node_69 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T17 and HUMMHGM_T35. Table 4807 below describes the starting and ending position of this segment on each transcript.

Table 4807 - Segment location on transcripts

This segment can be found in the following protein(s): HUMMHGM_P14.

Segment cluster HUMMHGM_node_74 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T28, HUMMHGM_T35 and HUMMHGM_T43. Table 4808 below describes the starting and ending position of this segment on each transcript.

Table 4808 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P14. This segment can also be found in the following protein(s): HUMMHGM_P21 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_l 13 according to the present invention is supported by 141 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4809 below describes the starting and ending position of this segment on each transcript.

Table 4809 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM J^>7, HUMMHGM_P9, HUMMHGM JPlO, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMMHGM_node_2 according to the present invention is supported by 234 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43, HUMMHGM_T44, HUMMHGM_T89 and HUMMHGM_T90. Table 4810 below describes the starting and ending position of this segment on each transcript. Table 4810 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7 and HUMMHGMJP63. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM J^>21, HUMMHGM_P24, HUMMHGM_P26 and HUMMHGM_P64, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_3 according to the present invention is supported by

250 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43, HUMMHGM_T44,

HUMMHGM_T89 and HUMMHGM_T90. Table 4811 below describes the starting and ending position of this segment on each transcript.

Table 4811 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7 and HUMMHGM_P63. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24, HUMMHGM_P26 and HUMMHGM_P64, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_4 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43, HUMMHGM_T44, HUMMHGM_T89 and HUMMHGM_T90. Table 4812 below describes the starting and ending position of this segment on each transcript.

Table 4812 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7 and HUMMHGMJP63. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGMJP14, HUMMHGMJP16, HUMMHGM_P21, HUMMHGM_P24, HUMMHGM_P26 and HUMMHGM_P64, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_5 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_ T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM T43, HUMMHGM_T44, HUMMHGM_T89 and HUMMHGM_T90. Table 4813 below describes the starting and ending position of this segment on each transcript.

Table 4813 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7 and HUMMHGM_P63. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM_P24, HUMMHGM_P26 and HUMMHGM_P64, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_6 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43, HUMMHGM_T44, HUMMHGM_T89 and HUMMHGM_T90. Table 4814 below describes the starting and ending position of this segment on each transcript.

Table 4814 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7 and HUMMHGM_P63. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGMJP14, HUMMHGM Pl 6, HUMMHGM_P21, HUMMHGM_P24, HUMMHGM_P26 and HUMMHGM_P64, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_8 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM _T89. Table 4815 below describes the starting and ending position of this segment on each transcript.

Table 4815 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P63.

Segment cluster HUMMHGM_node_18 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4816 below describes the starting and ending position of this segment on each transcript. Table 4816 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGMJP14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_20 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4817 below describes the starting and ending position of this segment on each transcript.

Table 4817 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGMJP12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_21 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM _T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4818 below describes the starting and ending position of this segment on each transcript.

Table 4818 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM__P9, HUMMHGMJUO, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_22 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM T17, HUMMHGM_T18, HUMMHGM T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM _T44. Table 4819 below describes the starting and ending position of this segment on each transcript. Table 4819 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGMJP9, HUMMHGMJP 10, HUMMHGMJ? 12, HUMMHGMJP 14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGMJP24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_23 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM Tl 5, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM _T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM _T44. Table 4820 below describes the starting and ending position of this segment on each transcript. Table 4820 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM J^>10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_24 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4821 below describes the starting and ending position of this segment on each transcript. Table 4821 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGMJU0, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript. Segment cluster HUMMHGM_node_25 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4822 below describes the starting and ending position of this segment on each transcript.

Table 4822 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGMJP12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_26 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4823 below describes the starting and ending position of this segment on each transcript.

Table 4823 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_27 according to the present invention can be found in the following transcript(s): HUMMHGMJK₅ HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4824 below describes the starting and ending position of this segment on each transcript.

Table 4824 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGMJ⁵16, HUMMHGMJP21, HUMMHGMJP24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_28 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4825 below describes the starting and ending position of this segment on each transcript.

Table 4825 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM P7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM JP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_29 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4826 below describes the starting and ending position of this segment on each transcript. Table 4826 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM-P 14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_30 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGMJMO, HUMMHGM_T43 and HUMMHGM_T44. Table 4827 below describes the starting and ending position of this segment on each transcript. Table 4827 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7. This segment can also be found in the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_32 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4828 below describes the starting and ending position of this segment on each transcript.

Table 4828 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM-P 10. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21 , HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_33 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4829 below describes the starting and ending position of this segment on each transcript.

Table 4829 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P10. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P12, HUMMHGMJP14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript. Segment cluster HUMMHGM_node_34 according to the present invention can be found in the following transcript(s): HUMMHGM _T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM__T43 and HUMMHGM_T44. Table 4830 below describes the starting and ending position of this segment on each transcript.

Table 4830 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P10. This segment can also be found in the following protein(s): HUMMHGMJP7, HUMMHGM_P9, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGMJP24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_35 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4831 below describes the starting and ending position of this segment on each transcript.

Table 4831 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P10. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGMJP9, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGMJP24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_37 according to the present invention can be found in the following transcript(s): HUMMHGM_T12, HUMMHGM_T13 and HUMMHGM_T18. Table 4832 below describes the starting and ending position of this segment on each transcript. Table 4832 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM JP9 and HUMMHGM_P10.

Segment cluster HUMMHGM_node_38 according to the present invention is supported by 331 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM__T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4833 below describes the starting and ending position of this segment on each transcript.

Table 4833 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9 and HUMMHGM_P10. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript. Segment cluster HUMMHGM_node_39 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4834 below describes the starting and ending position of this segment on each transcript.

Table 4834 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9 and HUMMHGM_P10. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_40 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, 38

2731

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4835 below describes the starting and ending position of this segment on each transcript.

Table 4835 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9 and HUMMHGM_P10. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM J^>21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_42 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T15, HUMMHGM_T18, HUMMHGM_T29 and HUMMHGM_T44. Table 4836 below describes the starting and ending position of this segment on each transcript.

Table 4836 - Segment location on transcripts

38

2732

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM JP12 and HUMMHGM_P9.

Segment cluster HUMMHGM_node_45 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4837 below describes the starting and ending position of this segment on each transcript.

Table 4837 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP9, HUMMHGM_P10, HUMMHGM_P12 and HUMMHGM_P16. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P14, HUMMHGM_P21 , HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_46 according to the present invention can be found in the following transcript(s): HUMMHGM_ T8, HUMMHGM_T 12, HUMMHGM_ T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T 18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM _T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4838 below describes the starting and ending position of this segment on each transcript. Table 4838 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP9, HUMMHGM_P10, HUMMHGM_P12 and HUMMHGM_P16. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P14, HUMMHGMJP21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript. Segment cluster HUMMHGM_node_47 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T 13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM _T35, HUMMHGM_T36, HUMMHGM _T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4839 below describes the starting and ending position of this segment on each transcript.

Table 4839 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12 and HUMMHGM_P16. This segment can also be found in the following protein(s): HUMMHGMJP7, HUMMHGM_P14, HUMMHGMJP21, HUMMHGMJP24 and HUMMHGMJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node__48 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4840 below describes the starting and ending position of this segment on each transcript.

Table 4840 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP9, HUMMHGMJPIO, HUMMHGM_P12 and HUMMHGM_P16. This segment can also be found in the following protein(s): HUMMHGMJP7, HUMMHGM_P14, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_49 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4841 below describes the starting and ending position of this segment on each transcript.

Table 4841 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12 and HUMMHGM_P16. This segment can also be found in the following protein(s): HUMMHGMJP7, HUMMHGMJ³14, HUMMHGM_P21, HUMMHGMJP24 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_51 according to the present invention is supported by 366 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4842 below describes the starting and ending position of this segment on each transcript.

Table 4842 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P16 and HUMMHGMJP24. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGMJP14, HUMMHGM_P21 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_52 according to the present invention is supported by 370 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HlJMMHGM _T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4843 below describes the starting and ending position of this segment on each transcript.

Table 4843 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P16 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P14, HUMMHGM JP21 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_53 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4844 below describes the starting and ending position of this segment on each transcript. Table 4844 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P16 and HUMMHGMJP24. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P14, HUMMHGM_P21 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_54 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4845 below describes the starting and ending position of this segment on each transcript. Table 4845 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P16 and HUMMHGMJP24. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P14, HUMMHGM_P21 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_55 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM _T44. Table 4846 below describes the starting and ending position of this segment on each transcript.

Table 4846 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM JP12, HUMMHGM_P16 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P14, HUMMHGM_P21 and HUMMHGM J^>26, since it is in the coding region for the corresponding transcript. Segment cluster HUMMHGM_node_56 according to the present invention can be found in the following transcript(s): HUMMHGM_T40. Table 4847 below describes the starting and ending position of this segment on each transcript.

Table 4847 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P24.

Segment cluster HUMMHGM_node_58 according to the present invention can be found in the following transcript(s): HUMMHGM_T40. Table 4848 below describes the starting and ending position of this segment on each transcript.

Table 4848 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P24.

Segment cluster HUMMHGM_node_61 according to the present invention can be found in the following transcript(s): HUMMHGM_T40. Table 4849 below describes the starting and ending position of this segment on each transcript.

Table 4849 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P24. Segment cluster HUMMHGM_node_62 according to the present invention can be found in the following transcript(s): HUMMHGM_T40. Table 4850 below describes the starting and ending position of this segment on each transcript.

Table 4850 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P24.

Segment cluster HUMMHGM_node_64 according to the present invention is supported by 162 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM Tl 7, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40 and HUMMHGM_T44. Table 4851 below describes the starting and ending position of this segment on each transcript.

Table 4851 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM JP12 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGM_P14 and HUMMHGM_P21, since it is in the coding region for the corresponding transcript. Segment cluster HUMMHGM_node_65 according to the present invention is supported by 168 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T 17, HUMMHGM _T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40 and HUMMHGM_T44. Table 4852 below describes the starting and ending position of this segment on each transcript.

Table 4852 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P12 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGM JP14 and HUMMHGM_P21, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_66 according to the present invention is supported by 169 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T17, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40 and HUMMHGM_T44. Table 4853 below describes the starting and ending position of this segment on each transcript.

Table 4853 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P12 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGMJP 14 and HUMMHGM JP21, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_67 according to the present invention can be found in the following transcript(s): HUMMHGM_T17, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM _T35, HUMMHGM_T36, HUMMHGM_T40 and HUMMHGM_T44. Table 4854 below describes the starting and ending position of this segment on each transcript.

Table 4854 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P12 and HUMMHGMJP24. This segment can also be found in the following protein(s): HUMMHGM_P14 and HUMMHGMJP21, since it is in the coding region for the corresponding transcript. Segment cluster HUMMHGM_node_68 according to the present invention is supported by 143 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T 17, HUMMHGM_T28, HUMMHGM_T29, HUMMHGMJB5, HUMMHGM_T36, HUMMHGM_T40 and HUMMHGM_T44. Table 4855 below describes the starting and ending position of this segment on each transcript.

Table 4855 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP12 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGM_P14 and HUMMHGM_P21, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_jnode_70 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4856 below describes the starting and ending position of this segment on each transcript.

Table 4856 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P21 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_71 according to the present invention is supported by 338 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4857 below describes the starting and ending position of this segment on each transcript.

Table 4857 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a noivcoding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGM_P7, HUMMHGM_P21 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_72 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4858 below describes the starting and ending position of this segment on each transcript. Table 4858 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16 and HUMMHGM_P24. This segment can also be found in the following protein(s): HUMMHGMJP7, HUMMHGMJP21 and HUMMHGM_P26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_73 according to the present invention is supported by 20 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMMHGM _T28, HUMMHGM_T35 and HUMMHGM T43. Table 4859 below describes the starting and ending position of this segment on each transcript.

Table 4859 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P14. This segment can also be found in the following protein(s): HUMMHGM_P21 and HUMMHGMJP26, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_75 according to the present invention is supported by 329 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4860 below describes the starting and ending position of this segment on each transcript.

Table 4860 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM P26. This segment can also be found in the following protein(s): HUMMHGMJP7, since it is in the coding region for the corresponding transcript.

Segment cluster HUMMHGM_node_76 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T 17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4861 below describes the starting and ending position of this segment on each transcript.

Table 4861 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_77 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4862 below describes the starting and ending position of this segment on each transcript.

Table 4862 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_78 according to the present invention is supported by 309 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4863 below describes the starting and ending position of this segment on each transcript.

Table 4863 - Segment location on transcripts

HUMMHGM T44 2506 2536

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM-P 16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_79 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4864 below describes the starting and ending position of this segment on each transcript.

Table 4864 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26. Segment cluster HUMMHGM_node_80 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T 13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM _T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4865 below describes the starting and ending position of this segment on each transcript.

Table 4865 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_81 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM _T43 and HUMMHGM_T44. Table 4866 below describes the starting and ending position of this segment on each transcript. Table 4866 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM Pl 6, HUMMHGMJP21 , HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGMjnode_82 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM _T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4867 below describes the starting and ending position of this segment on each transcript.

Table 4867 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_83 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM T15, HUMMHGM T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4868 below describes the starting and ending position of this segment on each transcript.

Table 4868 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM J^>12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_84 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGM_T40₃ HUMMHGM_T43 and HUMMHGM_T44. Table 4869 below describes the starting and ending position of this segment on each transcript.

Table 4869 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26. Segment cluster HUMMHGM_node_85 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4870 below describes the starting and ending position of this segment on each transcript.

Table 4870 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P 10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_86 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4871 below describes the starting and ending position of this segment on each transcript. Table 4871 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP7, HUMMHGM_P9, HUMMHGMJP 10, HUMMHGMJP12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_87 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4872 below describes the starting and ending position of this segment on each transcript.

Table 4872 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGMJP 14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_88 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM _T29, HUMMHGM_T35, HUMMHGM _T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4873 below describes the starting and ending position of this segment on each transcript.

Table 4873 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM JP7, HUMMHGM JP9, HUMMHGMJP 10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_89 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM T43 and HUMMHGM_T44. Table 4874 below describes the starting and ending position of this segment on each transcript.

Table 4874 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26. Segment cluster HUMMHGM_node_90 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T 15, HUMMHGM _Tl 7, HUMMHGM_T 18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM _T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4875 below describes the starting and ending position of this segment on each transcript.

Table 4875 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM JP9, HUMMHGMJUO, HUMMHGMJP12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_91 according to the present invention is supported by 282 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM _T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4876 below describes the starting and ending position of this segment on each transcript.

Table 4876 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_92 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4877 below describes the starting and ending position of this segment on each transcript.

Table 4877 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGMJP14, HUMMHGM P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_93 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4878 below describes the starting and ending position of this segment on each transcript.

Table 4878 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_94 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4879 below describes the starting and ending position of this segment on each transcript.

Table 4879 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26.

Segment cluster HUMMHGM__node_95 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4880 below describes the starting and ending position of this segment on each transcript.

Table 4880 - Segment location on transcripts

This segment can be found in a no n- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM P 12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_96 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4881 below describes the starting and ending position of this segment on each transcript.

Table 4881 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM JPlO, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_97 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 arri HUMMHGM_T44. Table 4882 below describes the starting and ending position of this segment on each transcript.

Table 4882 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_98 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4883 below describes the starting and ending position of this segment on each transcript.

Table 4883 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGMJPl^'β, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_99 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4884 below describes the starting and ending position of this segment on each transcript.

Table 4884 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26.

Segment cluster HUMMHGM_node_l 00 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4885 below describes the starting and ending position of this segment on each transcript.

Table 4885 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM node lOl according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4886 below describes the starting and ending position of this segment on each transcript.

Table 4886 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26.

Segment cluster HUMMHGM_node_102 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4887 below describes the starting and ending position of this segment on each transcript.

Table 4887 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP7, HUMMHGM P9, HUMMHGM JPlO, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_103 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGMJT40, HUMMHGM_T43 and HUMMHGM_T44. Table 4888 below describes the starting and ending position of this segment on each transcript.

Table 4888 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM J^>7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_104 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4889 below describes the starting and ending position of this segment on each transcript.

Table 4889 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGMJP7, HUMMHGM_P9, HUMMHGM_P10₅ HUMMHGM JP12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM_P24 and HUMMHGM_P26.

Segment cluster HUMMHGM_node_105 according to the present invention is supported by 238 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T 12, HUMMHGM _T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4890 below describes the starting and ending position of this segment on each transcript.

Table 4890 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGMJP9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM J^>14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_106 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_^Tl 8, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4891 below describes the starting and ending position of this segment on each transcript.

Table 4891 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_107 according to the present invention is supported by 219 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM _T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4892 below describes the starting and ending position of this segment on each transcript.

Table 4892 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_108 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4893 below describes the starting and ending position of this segment on each transcript.

Table 4893 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGMJP9, HUMMHGMJUO, HUMMHGM_P12, HUMMHGM JP14, HUMMHGM P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_l 09 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36,

HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4894 below describes the starting and ending position of this segment on each transcript.

Table 4894 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGMJP9, HUMMHGMJP 10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_l 10 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4895 below describes the starting and ending position of this segment on each transcript.

Table 4895 ~ Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P 10, HUMMHGM_P12, HUMMHGMJP14, HUMMHGMJP16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26. Segment cluster HUMMHGM_node_l 11 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM_T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4896 below describes the starting and ending position of this segment on each transcript.

Table 4896 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P 10, HUMMHGM_P12, HUMMHGMJ^>14, HUMMHGM_P16, HUMMHGM_P21, HUMMHGM P24 and HUMMHGM P26.

Segment cluster HUMMHGM_node_l 12 according to the present invention can be found in the following transcript(s): HUMMHGM_T8, HUMMHGM_T12, HUMMHGM_T13, HUMMHGM_T15, HUMMHGM_T17, HUMMHGM_T18, HUMMHGM_T20, HUMMHGM_T28, HUMMHGM _T29, HUMMHGM_T35, HUMMHGM_T36, HUMMHGM_T40, HUMMHGM_T43 and HUMMHGM_T44. Table 4897 below describes the starting and ending position of this segment on each transcript. Table 4897 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMMHGM_P7, HUMMHGM_P9, HUMMHGM_P10, HUMMHGM_P12, HUMMHGM_P14, HUMMHGM_P16, HUMMHGMJP21, HUMMHGM P24 and HUMMHGM P26.

DESCRIPTION FOR CLUSTER HUMPAX8A

Cluster HUMPAX8A features 13 transcript(s) and 29 segment(s) of interest, the names for which are given in Tables 4898 and 4899, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4900.

Table 4898 - Transcripts of interest

Transcript Name

HUMPAX8A TO

HUMPAX8A T2 HUMPAX8A T3

HUMPAX8A T4

HUMPAX8A T5

HUMPAX8A T7

HUMPAX8A T9

HUMPAX8A TlO

HUMPAX8A T15

HUMPAX8A T21

HUMPAX8A T27

HUMPAX8A_ J33

HUMPAX8A T34

Table 4899 - Segments of interest

Segment Nan*

HUMPAX8A node 4

HUMPAX8A node 5

HUMPAX8A_ node 8

HUMPAX8A node 15

HUMPAX8A node 17

HUMPAX8A node 18

HUMPAX8A node 20

HUMPAX8A node 21

HUMPAX8A node 22

HUMPAX8A node 32

HUMPAX8A node 39

HUMPAX8A node 41

HUMPAX8A node 42

HUMPAX8A node 43

HUMPAX8A node 44

HUMPAX8A node 49

HUMPAX8A node 50

HUMPAX8A node 0

HUMPAX8A node 2

HUMPAX8A node 12

HUMPAX8A node 19

HUMPAX8A node 24

HUMPAX8A node 25

HUMPAX8A node 30

HUMPAX8A node 31

HUMPAX8A node 40

HUMPAX8A node 46

HUMPAX8A node 47

HUMPAX8A node 48 Table 4900 - Proteins of interest

These sequences are variants of the known protein Paired box protein Pax- 8 (SwissProt accession identifier PAX8_HUMAN), referred to herein as the previously known protein.

Protein Paired box protein Pax- 8 is known or believed to have the following function(s): Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. The sequence for protein Paired box protein Pax- 8 is given at the end of the application, as "Paired box protein Pax-8 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4901.

Table 4901 - Amino acid mutations for Known Protein

Protein Paired box protein Pax-8 localization is believed to be Nuclear. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transcription regulation; morphogenesis; cell differentiation, which are annotation(s) related to Biological Process; transcription factor; thyroid-stimulating hormone receptor, which are annotation(s) related to Molecular Function; and nucbus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HUMPAX8A can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 122 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 122 and Table 4902. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues, ovarian carcinoma and uterine malignancies.

Table 4902 - Normal tissue distribution

Table 4903 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 4904.

Table 4904 - Oligonucleotides related to this cluster

As noted above, cluster HUMPAX8A features 29 segment(s), which were listed in Table 4899 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMPAX8A_node_4 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A T5. Table 4905 below describes the starting and ending position of this segment on each transcript.

Table 4905 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P3.

Segment cluster HUMPAX8A_node_5 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4906 below describes the starting and ending position of this segment on each transcript.

Table 4906 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P3. This segment can also be found in the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A_node_8 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4907 below describes the starting and ending position of this segment on each transcript.

Table 4907 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPAX8A_P1, HUMPAX8A P3 and HUMPAX8A PlO. Segment cluster HUMPAX8A_node_15 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4908 below describes the starting and ending position of this segment on each transcript.

Table 4908 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPAX8AJP1, HUMPAX8A P3 and HUMPAX8A PlO.

Segment cluster HUMPAX8A_node_17 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4909 below describes the starting and ending position of this segment on each transcript.

Table 4909 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPAX8A_P1, HUMPAX8A P3 and HUMP AX8A PlO.

Segment cluster HUMPAX8A_node_l 8 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21 and HUMPAX8A_T33. Table 4910 below describes the starting and ending position of this segment on each transcript.

Table 4910 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 4911. Table 4911 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P3.

Segment cluster HUMPAX8A_node_20 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21 and HUMPAX8A_T33. Table 4912 below describes the starting and ending position of this segment on each transcript.

Table 4912 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPAX8AJP1 and HUMPAX8A_P3.

Segment cluster HUMPAX8A_node_21 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21 and HUMPAX8A_T33. Table 4913 below describes the starting and ending position of this segment on each transcript.

Table 4913 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8AJP1 and HUMPAX8A_P3.

Segment cluster HUMPAX8A_node_22 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8AJTO, HUMPAX8A_T2,

HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4914 below describes the starting and ending position of this segment on each transcript.

Table 4914 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8AJP3. This segment can also be found in the following protein(s): HUMPAX8AJP10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A_node_32 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4915 below describes the starting and ending position of this segment on each transcript.

Table 4915 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1. This segment can also be found in the following protein(s): HUMPAX8A_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A_node_39 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T15 and HUMPAX8A_T27. Table 4916 below describes the starting and ending position of this segment on each transcript.

Table 4916 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P4.

Segment cluster HUMPAX8A_node_41 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T4 and HUMPAX8A_T10. Table 4917 below describes the starting and ending position of this segment on each transcript.

Table 4917 - Segment location on transcripts

This segment can be found in a non- coding region of transcriρt(s) that are related to the following protein(s): HUMPAX8A_P1.

Segment cluster HUMPAX8A_node_42 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HIJMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T15 and HUMPAX8A_T27. Table 4918 below describes the starting and ending position of this segment on each transcript. Table 4918 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8AJP1, HUMPAX8A_P3 and HUMPAX8A_P4.

Segment cluster HUMPAX8A_node_43 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T15 and HUMPAX8A_T27. Table 4919 below describes the starting and ending position of mis segment on each transcript.

Table 4919 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8AJP1 and HUMPAX8AJP3. This segment can also be found in the following protein(s): HUMPAX8AJP4, since it is in the coding region for the corresponding transcript. Segment cluster HUMPAX8A_node_44 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T15 and HUMPAX8A_T27. Table 4920 below describes the starting and ending position of this segment on each transcript.

Table 4920 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P3. This segment can also be found in the following protein(s): HUMPAX8AJP4, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A__node_49 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T15 and HUMPAX8A_T27. Table 4921 below describes the starting and ending position of this segment on each transcript.

Table 4921 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8AJP3. This segment can also be found in the following protein(s): HUMPAX8A_P4, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A_node_50 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2,

HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T15, HUMPAX8A_T21, HUMPAX8A_T27, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4922 below describes the starting and ending position of this segment on each transcript. Table 4922 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1, HUMPAX8A_P3 and HUMPAX8A_P10. This segment can also be found in the following protein(s): HUMPAX8AJP4, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMPAX8A_node_0 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8AJI21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4923 below describes the starting and ending position of this segment on each transcript.

Table 4923 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P10.

Segment cluster HUMPAX8A_node_2 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T7, HUMPAX8A_T9, HUMP AX8 A_TlO, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4924 below describes the starting and ending position of this segment on each transcript.

Table 4924 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P10.

Segment cluster HUMPAX8A_node_12 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8AJI3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4925 below describes the starting and ending position of this segment on each transcript. Table 4925 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPAX8A_P1, HUMPAX8A P3 and HUMP AX8A PlO.

Segment cluster HUMPAX8A_node_19 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21 and HUMPAX8A_T33. Table 4926 below describes the starting and ending position of this segment on each transcript.

Table 4926 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A P 1 and HUMPAX8A_P3.

Segment cluster HUMPAX8A_node_24 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4927 below describes the starting and ending position of this segment on each transcript.

Table 4927 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8AJP1 and HUMPAX8A_P3. This segment can also be found in the following protein(s): HUMPAX8A_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A_node_25 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4928 below describes the starting and ending position of this segment on each transcript.

Table 4928 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P3. This segment can also be found in the following protein(s): HUMPAX8A P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A_node_30 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8AJI3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9_; HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4929 below describes the starting and ending position of this segment on each transcript.

Table 4929 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8AJP3. This segment can also be found in the following protein(s): HUMPAX8A_P10, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A_node_31 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T4, HUMPAX8A_T7, HUMPAX8A_T10, HUMPAX8A_T21, HUMPAX8A_T33 and HUMPAX8A_T34. Table 4930 below describes the starting and ending position of this segment on each transcript.

Table 4930 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1. This segment can also be found in the following protein(s): HUMPAX8A_P10, since it is in the coding region for the corresponding transcript. Segment cluster HUMPAX8A_node_40 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T15 and HUMPAX8A_T27. Table 4931 below describes the starting and ending position of this segment on each transcript.

Table 4931 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 , HUMPAX8A_P3 and HUMPAX8A_P4.

Segment cluster HUMPAX8A_node_46 according to the present invention can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8 A_TlO, HUMPAX8A_T15 and HUMPAX8A_T27. Table 4932 below describes the starting and ending position of this segment on each transcript.

Table 4932 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P3. This segment can also be found in the following protein(s): HUMPAX8A_P4, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A_node_47 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T15 and HUMPAX8A_T27. Table 4933 below describes the starting and ending position of this segment on each transcript.

Table 4933 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P3. This segment can also be found in the following protein(s): HUMPAX8A_P4, since it is in the coding region for the corresponding transcript.

Segment cluster HUMPAX8A__node_48 according to the present invention can be found in the following transcript(s): HUMPAX8A_T0, HUMPAX8A_T2, HUMPAX8A_T3, HUMPAX8A_T4, HUMPAX8A_T5, HUMPAX8A_T7, HUMPAX8A_T9, HUMPAX8A_T10, HUMPAX8A_T15 and HUMPAX8A_T27. Table 4934 below describes the starting and ending position of this segment on each transcript.

Table 4934 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPAX8A_P1 and HUMPAX8A_P3. This segment can also be found in the following protein(s): HUMPAX8A_P4, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER HUMPOMCZ Cluster HUMPOMCZ features 5 transcript(s) and 53 segment(s) of interest, the names for which are given in Tables 4935 and 4936, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4937.

Table 4935 - Transcripts of interest

Table 4936 - Segments of interest

HUMPOMCZ PEA 1 node 30

HUMPOMCZ PEA 1 node 31

HUMPOMCZ PEA 1 node 32

HUMPOMCZ PEA 1 node 33

HUMPOMCZ PEA 1 node 34

HUMPOMCZ PEA 1 node 35

HUMPOMCZ PEA 1 node 36

HUMPOMCZ PEA 1 node 37

HUMPOMCZ PEA 1 node 38

HUMPOMCZ PEA 1 node 39

HUMPOMCZ PEA 1 node 40

HUMPOMCZ PEA 1 node 41

HUMPOMCZ PEA 1 node 42

HUMPOMCZ PEA 1 node 43

HUMPOMCZ PEA 1 node 44

HUMPOMCZ PEA 1 node 45

HUMPOMCZ PEA 1 node 46

HUMPOMCZ PEA 1 node 47

HUMPOMCZ PEA 1 node 48

HUMPOMCZ PEA 1 node 49

HUMPOMCZ PEA 1 node 50

HUMPOMCZ PEA 1 node 51

HUMPOMCZ PEA 1 node 52

HUMPOMCZ PEA 1 node 53

HUMPOMCZ PEA 1 node 54

HUMPOMCZ PEA 1 node 55

Table 4937 - Proteins of interest

These sequences are variants of the known protein Corticotropin- lipotropin precursor (SwissProt accession identifier COLIJHUMAN; known also according to the synonyms Pro¬ opiomelanocortin; POMC; Gamma-MSH; Adrenocorticotropic hormone; ACTH; Alpha-MSH; CLIP; Beta- LPH; Gamma-LPH; Beta-MSH), referred to herein as the previously known protein. Protein Corticotropin- lipotropin precursor is known or believed to have the following function(s): ACTH stimulates the adrenal glands to release cortisol;MSH (melanocyte- stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes;Beta-endorphin and Met- enkephalin are endogenous opiates. The sequence for protein Corticotropin- lipotropin precursor is given at the end of the application, as "Corticotropin- lipotropin precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 4938.

Table 4938 - Amino acid mutations for Known Protein

The previously known protein also has the following indication(s) and/or potential therapeutic use(s): Arthritis, rheumatoid; Amnesia; Alzheimer's disease; Pain; Sexual dysfunction, male; Macular degeneration; Multiple sclerosis, chronic progressive; Multiple sclerosis, relapsing-remitting; Multiple sclerosis. It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Adenylate cyclase stimulant; Corticotropin releasing factor agonist; Cyclic AMP agonist; Lipocortins synthesis agonist; Melanocortin agonist; Melanocyte stimulating hormone agonist; Opioid agonist. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drag database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: ACTH; Diagnostic; Antiarthritic; Cognition enhancer; Symptomatic antidiabetic; Radio/chemoprotective; Neurological; Analgesic; Male sexual dysfunction; Reproductive/gonadal, general; Multiple sclerosis treatment; Hormone; Ophthalmological. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: energy pathways; signal transduction; neuropeptide signaling pathway; cell-cell signaling, which are annotation(s) related to Biological Process; hormone, which are annotation(s) related to Molecular Function; and extracellular; soluble fraction, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster HUMPOMCZ features 53 segment(s), which were listed in Table

4936 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMPOMCZ_PEA_l_node_0 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZJPEA_1__T6, HUMP0MCZ_PEA_l_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZJPEA_1_T10. Table 4939 below describes the starting and ending position of this segment on each transcript.

Table 4939 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_10 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZJPEA__1_T9 and HUMPOMCZ_PEA_1_T10. Table 4940 below describes the starting and ending position of this segment on each transcript.

Table 4940 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_56 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_ 1_T10. Table 4941 below describes the starting and ending position of this segment on each transcript.

Table 4941 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_57 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZJPEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4942 below describes the starting and ending position of this segment on each transcript. Table 4942 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPOMCZ_PEA_1_P1.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMPOMCZ_PEA_l_node_l according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZJPEA_1_T6, HUMP0MCZ_PEA_l_T8, HUMP0MCZ_PEA_l_T9 and HUMPOMCZ_PEA_l_T10. Table 4943 below describes the starting and ending position of this segment on each transcript. Table 4943 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_3 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4944 below describes the starting and ending position of this segment on each transcript.

Table 4944 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_4 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZJPEA_1_T10. Table 4945 below describes the starting and ending position of this segment on each transcript. Table 4945 - Segment location on transcripts

I HUMPOMCZ PEA 1 TlO I 469 1 516 I

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_6 according to the present invention is supported by 14 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T8, HUMPOMCZ J?EA_1_T9 and HUMPOMCZ JPEAJ_TIO. Table 4946 below describes the starting and ending position of this segment on each transcript.

Table 4946 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPOMCZ_PEA_1 JPl.

Segment cluster HUMPOMCZJPEA_l_node_8 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMP0MCZ_PEA_l_T6 and HUMPOMCZ_PEA_1_T8. Table 4947 below describes the starting and ending position of this segment on each transcript. Table 4947 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMPOMCZ_PEA_1 J^>1. Segment cluster HUMPOMCZ_PEA_l_node_12 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZJPEA_1__T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZJPEA_1_T10. Table 4948 below describes the starting and ending position of this segment on each transcript.

Table 4948 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_13 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMP0MCZ_PEA_ l_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4949 below describes the starting and ending position of this segment on each transcript.

Table 4949 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1. Segment cluster HUMPOMCZ_PEA_l_node_14 according to the present invention can be found in the following transcript(s): HUMPOMCZ JPEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1 _T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4950 below describes the starting and ending position of this segment on each transcript.

Table 4950 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_15 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_l_T10. Table 4951 below describes the starting and ending position of this segment on each transcript.

Table 4951 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_16 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ J^>EA_1_T8, HUMPOMCZ_PEA_1_J9 and HUMPOMCZ_PEA_1_T10. Table 4952 below describes the starting and ending position of this segment on each transcript.

Table 4952 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ PEA I PI .

Segment cluster HUMPOMCZ_PEA_l_node_l 7 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4953 below describes the starting and ending position of this segment on each transcript.

Table 4953 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_1 jtiode_l 8 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3 , HUMPOMCZ_PEA_1_T6, HUMPOMCZJPEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4954 below describes the starting and ending position of this segment on each transcript.

Table 4954 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZJPEA 1 P1.

Segment cluster HUMPOMCZ_PEA_l_node_l 9 according to the present invention can be found in the following transcript(s): HUMPOMCZJPEAJ_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZJPEA I_TIO. Table 4955 below describes the starting and ending position of this segment on each transcript.

Table 4955 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_20 according to the present invention can be found in the following transcript(s): HUMP0MCZ_PEA_l_T3, HUMP0MCZ_PEA_l_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZJPEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4956 below describes the starting and ending position of this segment on each transcript.

Table 4956 - Segment location on transcripts

I HUMPOMCZ PEA 1 TlO | I 890 I I 896 I

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_21 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZJPEA_ 1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4957 below describes the starting and ending position of this segment on each transcript.

Table 4957 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ PEA IJPI.

Segment cluster HUMPOMCZ_PEA_l_node_22 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZJPEA_ 1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4958 below describes the starting and ending position of this segment on each transcript.

Table 4958 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1. Segment cluster HUMPOMCZ_PEA_l_node_23 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ J^>EA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4959 below describes the starting and ending position of this segment on each transcript.

Table 4959 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZJPEA_1JP1.

Segment cluster HUMPOMCZ_PEA_l_node_24 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZJPEA_1 _T6, HUMPOMCZ JPEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4960 below describes the starting and ending position of this segment on each transcript.

Table 4960 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_25 according to the present invention can be found in the following transcript(s): HUMP0MCZ_PEA__l_T3, HUMPOMCZ_PEA_1_T6, HUMPOMC Z_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4961 below describes the starting and ending position of this segment on each transcript.

Table 4961 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_26 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ JPEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4962 below describes the starting and ending position of this segment on each transcript.

Table 4962 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_27 according to the present invention can be found in the following transcript(s): HUMP0MCZ_PEA_l_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1__T9 and HUMPOMCZ_PEA_1_T10. Table 4963 below describes the starting and ending position of this segment on each transcript.

Table 4963 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1 JPl.

Segment cluster HUMPOMCZ_PEA_l_node_28 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMP0MCZ_PEA_l_T6, HUMPOMCZ JPEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4964 below describes the starting and ending position of this segment on each transcript.

Table 4964 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZJPEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_29 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMP0MCZ_PEA_l_T8, HUMPOMCZ J?EA_1_T9 and HUMPOMCZJPEAJ_TIO. Table 4965 below describes the starting and ending position of this segment on each transcript.

Table 4965 - Segment location on transcripts

HUMPOMCZ PEA 1 TlO 966 973

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_30 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4966 below describes the starting and ending position of this segment on each transcript.

Table 4966 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZJPEA IJPI.

Segment cluster HUMPOMCZ_PEA_l_node_31 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4967 below describes the starting and ending position of this segment on each transcript.

Table 4967 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1. Segment cluster HUMPOMCZ_PEA_l_node_32 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4968 below describes the starting and ending position of this segment on each transcript.

Table 4968 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ PEA_l_node_33 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4969 below describes the starting and ending position of this segment on each transcript.

Table 4969 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_34 according to the present invention can be found in the following transcript(s): HUMPOMCZ JPEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4970 below describes the starting and ending position of this segment on each transcript. Table 4970 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_35 according to the present invention can be found in the following transcript(s): HUMPOMCZ J?EA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZJPEAJ T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4971 below describes the starting and ending position of this segment on each transcript.

Table 4971 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_36 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4972 below describes the starting and ending position of this segment on each transcript.

Table 4972 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_37 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZJPEAJ _T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4973 below describes the starting and ending position of this segment on each transcript.

Table 4973 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_38 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4974 below describes the starting and ending position of this segment on each transcript.

Table 4974 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1. Segment cluster HUMPOMCZJPEA_l_node_39 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1__T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4975 below describes the starting and ending position of this segment on each transcript.

Table 4975 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_40 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ PEA 1 T3, HUMPOMCZ JPEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4976 below describes the starting and ending position of this segment on each transcript.

Table 4976 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZJPEAJJ¹I .

Segment cluster HUMPOMCZ_PEA_l_node_41 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4977 below describes the starting and ending position of this segment on each transcript.

Table 4977 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZJPEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_42 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEAJ_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4978 below describes the starting and ending position of this segment on each transcript.

Table 4978 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_43 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4979 below describes the starting and ending position of this segment on each transcript. Table 4979 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_44 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZJPEA_1_T10. Table 4980 below describes the starting and ending position of this segment on each transcript.

Table 4980 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_45 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZJPEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4981 below describes the starting and ending position of this segment on each transcript.

Table 4981 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZJPEA_1_P1.

Segment cluster HUMPOMCZ_PEA_1 node_46 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMP0MCZ_PEA_l_T6, HUMPOMCZ_PEA_1 _T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1 _TlO. Table 4982 below describes the starting and ending position of this segment on each transcript.

Table 4982 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZJPEA I PI.

Segment cluster HUMPOMCZ_PEA_l_node_47 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4983 below describes the starting and ending position of this segment on each transcript.

Table 4983 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1. Segment cluster HUMPOMCZ_PEA_l_node_48 according to the present invention can be found in the following transcript(s): HUMPOMCZJPEA_1_T3, HUMPOMCZ_PEA_1 _T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEAJ_T10. Table 4984 below describes the starting and ending position of this segment on each transcript.

Table 4984 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1J^>1.

Segment cluster HUMPOMCZ_PEA_l_node_49 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1 _T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4985 below describes the starting and ending position of this segment on each transcript.

Table 4985 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_50 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4986 below describes the starting and ending position of this segment on each transcript. Table 4986 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_51 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4987 below describes the starting and ending position of this segment on each transcript.

Table 4987 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ JPE A_l _P1.

Segment cluster HUMPOMCZ_PEA_l_node_52 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1 _T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4988 below describes the starting and ending position of this segment on each transcript.

Table 4988 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_53 according to the present invention can be found in the following transcript(s): HUMPOMCZ PEAJ_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4989 below describes the starting and ending position of this segment on each transcript.

Table 4989 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

Segment cluster HUMPOMCZ_PEA_l_node_54 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZ_PEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4990 below describes the starting and ending position of this segment on each transcript.

Table 4990 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1. Segment cluster HUMPOMCZJPEA_l_node_55 according to the present invention can be found in the following transcript(s): HUMPOMCZ_PEA_1_T3, HUMPOMCZ_PEA_1_T6, HUMPOMCZJPEA_1_T8, HUMPOMCZ_PEA_1_T9 and HUMPOMCZ_PEA_1_T10. Table 4991 below describes the starting and ending position of this segment on each transcript.

Table 4991 - Segment location on transcripts

This segment can be found in the following protein(s): HUMPOMCZ_PEA_1_P1.

DESCRIPTION FOR CLUSTER HUMRAP IGAP

Cluster HUMRAP IGAP features 17 transcript(s) and 65 segment(s) of interest, the names for which are given in Tables 4992 and 4993, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 4994.

Table 4992 - Transcripts of interest

Transcript Name

HUMRAPIGAP Tl

HUMRAPIGAP T2

HUMRAPIGAP T3

HUMRAPIGAP T4

HUMRAPIGAP T5

HUMRAPIGAP T6

HUMRAPIGAP T7

HUMRAPIGAP T22

HUMRAPIGAP T33

HUMRAPIGAP T34 HUMRAP IGAP T36

HUMRAP IGAP T37

HUMRAP IGAP T41

HUMRAPl GAP T47

HUMRAPl GAP T52

HUMRAP IGAP T55

HUMRAP IGAP T56

Table 4993 - Segments of interest

Segment Name

HUMRAP IGAP node 0

HUMRAP IGAP node 3

HUMRAPl GAP node 10

HUMRAP IGAP node 12

HUMRAP IGAP node 13

HUMRAPl GAP node 19

HUMRAP1GAP node 29

HUMRAP1GAP node 42

HUMRAP1GAP node 52

HUMRAP IGAP node 66

HUMRAP1GAP node 67

HUMRAP1GAP node 74

HUMRAP1GAP node 75

HUMRAPl GAP node 85

HUMRAP IGAP node 88

HUMRAP1GAP node 98

HUMRAP IGAP node 107

HUMRAPl GAP node 111

HUMRAPl GAP node 2

HUMRAP IGAP node 5

HUMRAPl GAP node 7

HUMRAPl GAP node 8

HUMRAPIGAP node J 5

HUMRAPIGAP node 17

HUMRAPl GAP node 23

HUMRAPIGAP node 25

HUMRAPIGAP node 27

HUMRAPIGAP node 34

HUMRAPIGAP node 37

HUMRAPIGAP node 38

HUMRAPIGAP node 41

HUMRAPIGAP node 46

HUMRAPIGAP node 47 HUMRAP IGAP node 49

HUMRAP IGAP node 50

HUMRAP IGAP node 54

HUMRAPl GAP node 55

HUMRAP IGAP node 56

HUMRAP IGAP node 58

HUMRAPl GAP node 61

HUMRAP IGAP node 63

HUMRAP IGAP node 64

HUMRAPl GAP node _73

HUMRAP IGAP node 76

HUMRAP IGAP node 77

HUMRAP IGAP node 78

HUMRAP IGAP node 81

HUMRAP IGAP node 84

HUMRAP IGAP node 87

HUMRAP IGAP node 89

HUMRAPl GAP node 90

HUMRAPIGAP node 91

HUMRAP IGAP node 92

HUMRAPIGAP node 93

HUMRAPIGAP node 94

HUMRAPIGAP node 97

HUMRAPIGAP node 100

HUMRAPIGAP node 101

HUMRAP1GAP_ node_ _102

HUMRAPIGAP node 104

HUMRAPIGAP node 105

HUMRAPIGAP node 106

HUMRAPIGAP node 108

HUMRAPIGAP node 109

HUMRAPIGAP node 110

Table 4994 - Proteins of interest

These sequences are variants of the known protein Rapl GTPase- activating protein 1 (SwissProt accession identifier RGP2_HUMAN; known also according to the synonyms Rap IGAP), referred to herein as the previously known protein. Protein Rapl GTPase- activating protein 1 is known or believed to have the following function(s): GTPase activator for the nuclear Ras- related regulatory protein RAP-IA (KREV-I), converting it to the putatively inactive GDP -bound state. The sequence for protein Rapl GTPase- activating protein 1 is given at the end of the application, as "Rapl GTPase- activating protein 1 amino acid sequence". Protein Rapl GTPase- activating protein 1 localization is believed to be Associated with Golgi membranes.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: signal transduction, which are annotation(s) related to Biological Process; GTPase activator, which are annotation(s) related to Molecular Function; and membrane, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from ^ttp^/www.ncbi.nhn.nih.gov/projects/LocusLinl^.

As noted above, cluster HUMRAPIGAP features 65 segment(s), which were listed in Table 2 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster HUMRAP IGAPjnode O according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_T2, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAPl GAP_T22, HUMRAPl G AP_T33, HUMRAP 1GAP_T34, HUMRAP 1GAP_T47, HUMRAP1GAP_T52, HUMRAP 1GAP_T55 and HUMRAPl GAP T56. Table 4995 below describes the starting and ending position of this segment on each transcript.

Table 4995 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP1GAP_P3 and HUMRAP 1GAP_P 16. This segment can also be found in the following protein(s): HUMRAPl G AP_P1, HUMRAP1GAP_P6, HUMRAPl GAP_P35, HUMRAP 1GAP_P4O, HUMRAP 1GAP_P43 and HUMRAP 1GAP_P44, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAPl GAP_node_3 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T52. Table 4996 below describes the starting and ending position of this segment on each transcript.

Table 4996 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP_P4O.

Segment cluster HUMRAP 1 GAP_node_l 0 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP T4. Table 4997 below describes the starting and ending position of this segment on each transcript.

Table 4997 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP P46.

Segment cluster HUMRAP lGAP_node_l 2 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP Tl and HUMRAP1GAP_T3. Table 4998 below describes the starting and ending position of this segment on each transcript.

Table 4998 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46. Segment cluster HUMRAPl GAP_node_ 13 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP T3. Table 4999 below describes the starting and ending position of this segment on each transcript.

Table 4999 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAPJP46.

Segment cluster HUMRAP lGAP_node_l 9 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP T55 and HUMRAP1GAP T56. Table 5000 below describes the starting and ending position of this segment on each transcript.

Table 5000 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAPl GAP_P44. This segment can also be found in the following protein(s): HUMRAP 1GAP_P43, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_29 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP Tl, HUMRAP 1GAP_T2, HUMRAP 1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAPl G AP_T33, HUMRAPl GAP_T34 and HUMRAP 1GAP_T47. Table 5001 below describes the starting and ending position of this segment on each transcript.

Table 5001 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P46, HUMRAPl G APJP3, HUMRAP IGAP Pl, HUMRAP1GAP_P6 and HUMRAP1GAP_P35.

Segment cluster HUMRAP lGAP_node_42 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T47. Table 5002 below describes the starting and ending position of this segment on each transcript.

Table 5002 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P35.

Segment cluster HUMRAP lGAP_node_52 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_T1, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAPl GAP_T7, HUMRAP 1GAP_T22, HUMRAPl G AP_T33 and HUMRAP 1GAP__T34. Table 5003 below describes the starting and ending position of this segment on each transcript.

Table 5003 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAPl G AP P46,

HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP1GAP_P1 and HUMRAP 1GAP_P6.

Segment cluster HUMRAP lGAPjtiode 66 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP T36 and HUMRAPl GAP_T37. Table 5004 below describes the starting and ending position of this segment on each transcript.

Table 5004 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAPl G APJP24 and HUMRAPIGAP P25.

Segment cluster HUMRAP lGAP_node_67 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAPl G AP_T3, HUMRAPl G AP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAPl G AP_T22, HUMRAPl G AP_T33, HUMRAP 1GAP_T34, HUMRAP 1GAP_T36 and HUMRAPl G AP_T37. Table 5005 below describes the starting and ending position of this segment on each transcript.

Table 5005 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAPJP46, HUMRAP1GAP_P3, HUMRAP IGAP P 16, HUMRAPl G APJPl, HUMRAP 1GAPJP6, HUMRAPIGAP P24 and HUMRAPIGAP P25.

Segment cluster HUMRAP lGAP_node_74 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP T36. Table 5006 below describes the starting and ending position of this segment on each transcript.

Table 5006 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAPJP24. Segment cluster HUMRAP lGAP_node_75 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMPvAPl G APJB 6. Table 5007 below describes the starting and ending position of this segment on each transcript.

Table 5007 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP_P24.

Segment cluster HUMRAPlGAP_node_85 according to the present invention is supported by 98 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP Tl, HUMRAPl G AP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAPl G AP_T33, HUMRAP 1GAP_T34, HUMRAP1GAP_T36, HUMRAP 1GAP T37 and HUMRAPl G AP_T41. Table 5008 below describes the starting and ending position of this segment on each transcript.

Table 5008 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAPl G AP_P24 and HUMRAP 1GAP_P29. This segment can also be found in the following protein(s): HUMRAPl G AP_P46, HUMRAP 1GAP_P3, HUMRAPl GAP J^>16, HUMRAPl G APJPl, HUMRAPl GAP_P6 and HUMRAPl G AP_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_88 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T41. Table 5009 below describes the starting and ending position of this segment on each transcript.

Table 5009 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAPl GAPJP29.

Segment cluster HUMRAP lGAP_node_98 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T33 and HUMRAP 1GAP_T34. Table 5010 below describes the starting and ending position of this segment on each transcript.

Table 5010 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1 GAPJP 1 and HUMRAPl GAPJP6. Segment cluster HUMRAP lGAP_node_l 07 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_T1, HUMRAP 1GAP_T2, HUMRAPl G AP_T3, HUMRAPl G AP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP IG AP _T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T36, HUMRAP 1GAP_T37 and HUMRAPl G AP_T41. Table 5011 below describes the starting and ending position of this segment on each transcript.

Table 5011 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAPJP46, HUMRAP 1GAP_P3, HUMRAP IGAPJP 16, HUMRAP 1GAP_P24, HUMRAP 1GAPJP25 and HUMRAP 1GAP_P29.

Segment cluster HUMRAP lGAP_node_l 11 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP IGAP _T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T36, HUMRAP 1GAP_T37 and HUMRAPl GAP_T41. Table 5012 below describes the starting and ending position of this segment on each transcript.

Table 5012 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP P3, HUMRAP 1GAP_P 16, HUMRAP1GAP P24, HUMRAP 1GAP_P25 and HUMRAP1GAP_P29.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMRAP lGAP_node_2 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T6, HUMRAP 1GAP_T22, HUMRAP1GAP_T52 and HUMRAP1GAP_T56. Table 5013 below describes the starting and ending position of this segment on each transcript.

Table 5013 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5014.

Table 5014 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAPJP46 and HUMRAP 1GAP_P 16. This segment can also be found in the following protein(s): HUMRAP 1GAPJP40 and HUMRAPl GAP JP44, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_5 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T5. Table 5015 below describes the starting and ending position of this segment on each transcript.

Table 5015 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s) : HUMRAP 1 GAP_P46.

Segment cluster HUMRAP lGAP_node_7 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T2, HUMRAP 1GAP_T5, HUMRAP1GAP_T7, HUMRAP 1GAP_T22 and HUMRAP 1GAP_T56. Table 5016 below describes the starting and ending position of this segment on each transcript. Table 5016 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAPl GAP_P46, HUMRAP 1GAP P3 and HUMRAP IGAP P 16. This segment can also be found in the following protein(s): HUMRAP 1 GAP P44, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_8 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T2, HUMRAP 1GAP_T5, HUMRAP1GAP_T7 and HUMRAP 1GAP T56. Table 5017 below describes the starting and ending position of this segment on each transcript.

Table 5017 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP1GAP_P3 and HUMRAP 1GAP_P44.

Segment cluster HUMRAP lGAP_node_l 5 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAPl GAP_T2, HUMRAP1GAP_T3, HUMRAP 1 GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP1GAP_T33, HUMRAP 1GAP_T34, HUMRAP 1GAP__T47, HUMRAPl G AP_T55 and HUMRAP 1GAP_T56. Table 5018 below describes the starting and ending position of this segment on each transcript.

Table 5018 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46 and HUMRAPl GAP_P44. This segment can also be found in the following protein(s): HUMRAP 1GAP_P1, HUMRAP 1GAP_P6, HUMRAP 1GAP_P35 and HUMRAPl G AP_P43, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_l 7 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP1GAP_T7, HUMRAP 1GAP_T33, HUMRAPl GAP_T34, HUMRAP 1GAP_T47, HUMRAP1GAP_T55 and HUMRAP 1GAP_T56. Table 5019 below describes the starting and ending position of this segment on each transcript.

Table 5019 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP1GAP_P3 and HUMRAP 1GAP_P44. This segment can also be found in the following protein(s): HUMRAPl G APJPl, HUMRAP 1GAJPJP6, HUMRAP 1GAPJP35 and HUMRAP 1GAP_P43, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_23 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP1GAP_T7, HUMRAP 1GAP_T33, HUMRAP 1GAP_T34 and HUMRAPl G AP_T47. Table 5020 below describes the starting and ending position of this segment on each transcript. Table 5020 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAPl G AP_P1, HUMRAP1GAP_P6 and HUMRAP 1GAP_P35.

Segment cluster HUMRAP lGAP_node_25 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAPl G AP T33, HUMRAP 1GAP_T34 and HUMRAPl G AP_T47. Table 5021 below describes the starting and ending position of this segment on each transcript.

Table 5021 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P46, HUMRAP 1GAP_P3, HUMRAPl G AP_P1, HUMRAP 1GAPJP6 and HUMRAPl GAP_P35.

Segment cluster HUMRAP lGAP_node_27 according to the present invention is supported by 34 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAPl GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAPl GAP_T7, HUMRAPl G AP_T33, HUMRAP 1GAP_T34 and HUMRAP 1GAP_T47. Table 5022 below describes the starting and ending position of this segment on each transcript.

Table 5022 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P46,

HUMRAPl GAP_P3, HUMRAP 1GAP_P1, HUMRAPIGAP P6 and HUMRAP 1GAP_P35.

Segment cluster HUMRAP lGAP_node_34 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP IGAP _T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T33, HUMRAP 1GAP_T34 and HUMRAP 1GAP_T47. Table 5023 below describes the starting and ending position of this segment on each transcript.

Table 5023 - Segment location on transcripts

HUMRAP IGAP T47 970 1073

This segment can be found in the following protein(s): HUMRAP 1GAPJP46, HUMRAP1GAP_P3, HUMRAPl G APJPl, HUMRAP1GAPJP6 and HUMRAP 1GAP_P35.

Segment cluster HUMRAP lGAP_node_37 according to the present invention is supported by 43 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP Tl, HUMRAPl GAP _T2, HUMRAP 1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAPl G AP_T33, HUMRAP 1GAP_T34 and HUMRAPl G AP_T47. Table 5024 below describes the starting and ending position of this segment on each transcript.

Table 5024 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAPJP46, HUMRAP1GAP_P3, HUMRAP 1GAP_P1, HUMRAP1GAPJP6 and HUMRAP 1GAP_P35.

Segment cluster HUMRAP lGAP_node_38 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP IGAP _T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP1GAP_T7, HUMRAP1GAP_T33, HUMRAPl GAP_T34 and HUMRAP 1GAP_T47. Table 5025 below describes the starting and ending position of this segment on each transcript. Table 5025 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P46, HUMRAP1GAP_P3, HUMRAP 1GAP_P1, HUMRAP1GAP_P6 and HUMRAPl GAP_P35.

Segment cluster HUMRAP lGAP_node_41 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T1, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP1GAP_T7, HUMRAP1GAP_T33, HUMRAP 1GAP_T34 and HUMRAP 1GAP_T47. Table 5026 below describes the starting and ending position of this segment on each transcript.

Table 5026 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1 GAP_P46, HUMRAPl GAP_P3, HUMRAP IGAPJPl, HUMRAP1GAP_P6 and HUMRAPl G AP_P35.

Segment cluster HUMRAP lGAP_node_46 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP1GAP_T7, HUMRAP 1GAP_T33 and HUMRAPl GAP_T34. Table 5027 below describes the starting and ending position of this segment on each transcript.

Table 5027 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP1GAP_P3, HUMRAP1GAP_P1 and HUMRAP 1GAP_P6.

Segment cluster HUMRAP lGAP_node_47 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP IGAP _T6, HUMRAP1GAP_T7, HUMRAP 1GAP_T33 and HUMRAP 1GAP_T34. Table 5028 below describes the starting and ending position of this segment on each transcript.

Table 5028 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAPl GAP_P3, HUMRAPIGAP JPl and HUMRAP 1GAP_P6.

Segment cluster HUMRAP 1 GAP_node_49 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2, HUMRAP 1GAP T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP T22, HUMRAP 1GAP_T33 and HUMRAP 1GAP_T34. Table 5029 below describes the starting and ending position of this segment on each transcript.

Table 5029 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P 16. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP1GAP_P1 and HUMRAP 1GAP P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_50 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2, HUMRAPl GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAPl G AP_T33 and HUMRAP IGAP _T34. Table 5030 below describes the starting and ending position of this segment on each transcript.

Table 5030 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P 16. This segment can also be found in the following protein(s): HUMRAP 1GAPJP46, HUMRAP 1GAP_P3, HUMRAP1GAP_P1 and HUMRAP 1GAP_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_54 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1 GAP_T33 and HUMRAP 1GAP_T34. Table 5031 below describes the starting and ending position of this segment on each transcript.

Table 5031 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P46,

HUMRAPl GAP P3, HUMRAP 1GAP_P 16, HUMRAPIGAPJPI and HUMRAP 1GAP_P6.

Segment cluster HUMRAP lGAP_node_55 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAPl GAP_T33 and HUMRAP 1GAP_T34. Table 5032 below describes the starting and ending position of this segment on each transcript.

Table 5032 - Segment location on transcripts

HUMRAP IGAP T34 1600 1625

This segment can be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP1GAP_P3, HUMRAP1GAP_P16, HUMRAP1GAP_P1 and HUMRAP IGAP P6.

Segment cluster HUMRAPl GAP_node_56 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2, HUMRAP 1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAPl GAP_T33 and HUMRAP 1GAP_T34. Table 5033 below describes the starting and ending position of this segment on each transcript.

Table 5033 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP1GAP_P1 and HUMRAP 1GAP_P6.

Segment cluster HUMRAP lGAP_node_58 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP IGAP _T22, HUMRAP IGAP _T33 and HUMRAP 1GAP_T34. Table 5034 below describes the starting and ending position of this segment on each transcript. Table 5034 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P46, HUMRAP1GAP_P3, HUMRAP IGAJPJP 16, HUMRAP1GAP_P1 and HUMRAP 1GAP_P6.

Segment cluster HUMRAP lGAP_node_61 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAPlGAPjπ, HUMRAP 1GAP_T22, HUMRAP 1GAP_T33 and HUMRAPl G AP_T34. Table 5035 below describes the starting and ending position of this segment on each transcript.

Table 5035 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAPl GAP_P3, HUMRAP 1GAPJ^>16, HUMRAP1GAP_P1 and HUMRAP IGAP J^>6.

Segment cluster HUMRAPl GAP_node_63 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP Tl, HUMRAP 1GAP T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T33 and HUMRAP 1GAP_T34. Table 5036 below describes the starting and ending position of this segment on each transcript.

Table 5036 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P46, HUMRAP1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP1GAP_P1 and HUMRAP 1GAP_P6.

Segment cluster HUMRAP lGAP_node_64 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2, HUMRAP 1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP1GAP_T7, HUMRAP 1GAP_T22, HUMRAPl GAP_T33 and HUMRAP 1GAP_T34. Table 5037 below describes the starting and ending position of this segment on each transcript.

Table 5037 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P46, HUMRAP1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP1GAP_P1 and HUMRAP 1GAP_P6.

Segment cluster HUMRAP lGAP_node_73 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T36. Table 5038 below describes the starting and ending position of this segment on each transcript.

Table 5038 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP_P24.

Segment cluster HUMRAP lGAP_node_76 according to the present invention can be found in the following transcript(s): HUMRAP 1 GAP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAPIGAP _T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T33, HUMRAP 1GAP_T34, HUMRAP1GAP_T36 and HUMRAPIGAP _T37. Table 5039 below describes the starting and ending position of this segment on each transcript.

Table 5039 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P24. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAPl GAP_P3, HUMRAP 1GAP_P 16, HUMRAPl GAPJPl, HUMRAP1GAP_P6 and HUMRAP1GAPJP25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_77 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T1, HUMRAP 1GAP_T2, HUMRAP 1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP T6, HUMRAP 1GAP T7, HUMRAP 1GAP_T22, HUMRAPl GAP_T33, HUMRAP 1GAP_T34, HUMRAP 1GAP_T36 and HUMRAP 1GAP_T37. Table 5040 below describes the starting and ending position of this segment on each transcript.

Table 5040 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAPl GAP P24. This segment can also be found in the following protein(s): HUMRAP 1GAP P46, HUMRAP 1GAP P3, HUMRAP 1GAP_P 16, HUMRAPl G APJPl, HUMRAP1GAPJP6 and HUMRAP1GAP P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_78 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP _T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T33, HUMRAP 1GAP_T34, HUMRAP1GAP_T36 and HUMRAP 1GAP_T37. Table 5041 below describes the starting and ending position of this segment on each transcript.

Table 5041 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAPl G APJP24. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP 1GAP_P1, HUMRAP 1GAP_P6 and HUMRAP 1GAP_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_81 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP IGAP _T6, HUMRAP1GAP_T7, HUMRAPl GAP_T22, HUMRAPl G AP_T33, HUMRAP 1GAP_T34, HUMRAP1GAP_T36 and HUMRAP1GAP_T37. Table 5042 below describes the starting and ending position of this segment on each transcript.

Table 5042 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP P24. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16,

HUMRAP IGAP Pl, HUMRAP1GAP_P6 and HUMRAP1GAP_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_84 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_T41. Table 5043 below describes the starting and ending position of this segment on each transcript.

Table 5043 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAPl GAPJP29.

Segment cluster HUMRAP lGAP_node_87 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T1, HUMRAP1GAP_T2, HUMRAPl G AP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAPl GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T33, HUMRAP 1GAP T34, HUMRAPl GAP_T36, HUMRAP 1GAP_T37 and HUMRAP 1 GAP_T41. Table 5044 below describes the starting and ending position of this segment on each transcript.

Table 5044 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P24 and HUMRAP 1GAP_P29. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAPl G AP_P3, HUMRAP1GAP_P16, HUMRAP 1GAP_P1, HUMRAP1GAP_P6 and HUMRAP 1GAP_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAPl GAP_node_89 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T34 and HUMRAP 1GAP_T41. Table 5045 below describes the starting and ending position of this segment on each transcript.

Table 5045 - Segment location on transcripts

This segment can be found in the following protein(s): HUMRAP 1GAP P6 and HUMRAPIGAP P29.

Segment cluster HUMRAPl G AP_node_90 according to the present invention can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2,

HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAPl GAP T22, HUMRAP 1GAP_T33, HUMRAP 1GAP_T34, HUMRAP 1GAP_T36, HUMRAP 1GAP_T37 and HUMRAPl G AP_T41. Table 5046 below describes the starting and ending position of this segment on each transcript.

Table 5046 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcripts) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP P24. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP IGAP P 16, HUMRAP1GAP_P1, HUMRAPl GAP_P6, HUMRAPl GAP_P25 and HUMRAP 1GAP_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_91 according to the present invention can be found in the following transcript(s): HUMRAPl G AP Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAPlGAPjπ, HUMRAP 1GAP_T22, HUMRAP1GAP_T33, HUMRAP 1GAP_T34, HUMRAP1GAP_T36, HUMRAP 1GAP_T37 and HUMRAP 1GAP_T41. Table 5047 below describes the starting and ending position of this segment on each transcript.

Table 5047 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P24. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP IGAP P 16, HUMRAP IGAPJPl, HUMRAPl GAPJP6, HUMRAP 1GAPJP25 and HUMRAP 1GAP_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_92 according to the present invention can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2,

HUMRAPl G AP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP1GAP_T7, HUMRAP 1GAP_T22, HUMRAP1GAP_T33, HUMRAP 1GAP_T34, HUMRAP 1GAP_T36, HUMRAP 1GAP_T37 and HUMRAPl G AP_T41. Table 5048 below describes the starting and ending position of this segment on each transcript. Table 5048 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P24. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAPJP3, HUMRAP 1GAP_P 16, HUMRAPl G AP_P1, HUMRAP 1GAP_P6, HUMRAP 1GAP_P25 and HUMRAP 1GAP_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_93 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T33, HUMRAP 1GAP_T34, HUMRAP1GAP_T36, HUMRAP 1GAP_T37 and HUMRAPl G AP_T41. Table 5049 below describes the starting and ending position of this segment on each transcript.

Table 5049 - Segment location on transcripts

HUMRAP IGAP T41 653 709

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P24. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP IGAP Pl, HUMRAPl GAP P6, HUMRAP 1GAP_P25 and HUMRAPl GAP_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_94 according to the present invention can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP 1GAP_T2,

HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAPl GAP_T6, HUMRAP 1GAP T7, HUMRAP 1GAP_T22, HUMRAPl GAP T33, HUMRAP 1GAP_T34, HUMRAP 1GAP_T36, HUMRAPl G AP T37 and HUMRAP 1GAP_T41. Table 5050 below describes the starting and ending position of this segment on each transcript. Table 5050 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP1GAP_P6 and HUMRAP 1GAP_P24. This segment can also be found in the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1 GAP_P 16, HUMRAP 1 GAP_P 1 , HUMRAP 1 G AP_P25 and HUMRAP 1 GAP_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_97 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAPl G AP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAPl G AP_T22, HUMRAPl G APJB 3, HUMRAPl GAP_T34, HUMRAP 1GAP_T36, HUMRAP IGAP _T37 and HUMRAPl GAP JT41. Table 5051 below describes the starting and ending position of this segment on each transcript.

Table 5051 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP1GAPJP6 and HUMRAPl GAP_P24. This segment can also be found in the following protein(s): HUMRAP 1GAPJP46, HUMRAP 1GAPJP3, HUMRAP1GAPJP16, HUMRAP 1GAP_P1, HUMRAP IGAP JP25 and HUMRAP IGAP JP29, since it is in the coding region for the corresponding transcript. Segment cluster HUMRAPl GAP_node_l 00 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1 G AP_T1 , HUMRAP IG AP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAPl G AP T5, HUMRAP 1GAP_T6, HUMRAPl GAP T7, HUMRAP 1GAPJT22, HUMRAP 1GAP_T36, HUMRAPl G AP_T37 and HUMRAP 1GAP T41. Table 5052 below describes the starting and ending position of this segment on each transcript.

Table 5052 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAPJP46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP 1GAP_P24 and HUMRAP 1GAP_P25. This segment can also be found in the following protein(s): HUMRAP 1GAP_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_l 01 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP 1GAP_T1, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6,

HUMRAP 1GAP_T7, HUMRAP 1GAP T22, HUMRAP 1GAP_T36, HUMRAPl G AP_T37 and HUMRAP 1GAP_T41. Table 5053 below describes the starting and ending position of this segment on each transcript.

Table 5053 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP IGAP JP46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP 1GAP_P24 and HUMRAP1GAP_P25. This segment can also be found in the following protein(s): HUMRAP 1GAP P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAPl GAP_node_l 02 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_T1, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6,

HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAPl GAP_T36, HUMRAPl G AP_T37 and HUMRAPl GAP_T41. Table 5054 below describes the starting and ending position of this segment on each transcript.

Table 5054 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP 1GAP_P24 and HUMRAP1GAP_P25. This segment can also be found in the following protein(s): HUMRAP 1GAP_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP node l 04 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_T1, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T36, HUMRAP 1GAP_T37 and HUMRAP 1GAP T41. Table 5055 below describes the starting and ending position of this segment on each transcript.

Table 5055 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAPl G AP_P3, HUMRAP 1GAP_P 16, HUMRAP 1GAP_P24 and HUMRAP 1GAP_P25. This segment can also be found in the following protein(s): HUMRAP 1GAP_P29, since it is in the coding region for the corresponding transcript.

Segment cluster HUMRAP lGAP_node_l 05 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_Tl, HUMRAP 1GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAPl GAP_T36, HUMRAPl GAP_T37 and HUMRAP 1GAP_T41. Table 5056 below describes the starting and ending position of this segment on each transcript.

Table 5056 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAPl GAP_P24, HUMRAP 1GAP_P25 and HUMRAP 1GAP_P29.

Segment cluster HUMRAP lGAP_node_l 06 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_T1, HUMRAP 1GAP_T2, HUMRAP 1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T36, HUMRAP1GAP_T37 and HUMRAPl G AP_T41. Table 5057 below describes the starting and ending position of this segment on each transcript.

Table 5057 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP1GAP_P24, HUMRAP 1GAP_P25 and HUMRAP 1GAP_P29.

Segment cluster HUMRAPlGAP_node_108 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAPl G AP_T1, HUMRAP 1GAP_T2, HUMRAP 1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T36, HUMRAP 1GAP_T37 and HUMRAP 1 G AP_T41. Table 5058 below describes the starting and ending position of this segment on each transcript.

Table 5058 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP 1GAP_P24, HUMRAP 1GAP_P25 and HUMRAP 1GAP P29.

Segment cluster HUMRAP lGAP_node_l 09 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMRAP IGAP_Tl, HUMRAP1GAP_T2, HUMRAPl G AP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5₅ HUMRAP1GAP_T6, HUMRAP 1GAP_T7, HUMRAP 1GAP_T22, HUMRAP 1GAP_T36, HUMRAP1GAP_T37 and HUMRAP 1GAP_T41. Table 5059 below describes the starting and ending position of this segment on each transcript.

Table 5059 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP 1GAP_P24, HUMRAP 1GAP_P25 and HUMRAP 1GAP_P29.

Segment cluster HUMRAP lGAP node l 10 according to the present invention can be found in the following transcript(s): HUMRAPl GAP_Tl, HUMRAPl GAP_T2, HUMRAP1GAP_T3, HUMRAP 1GAP_T4, HUMRAP 1GAP_T5, HUMRAP 1GAP_T6, HUMRAP 1GAP T7, HUMRAP 1GAP_T22, HUMRAPl GAP_T36, HUMRAP 1GAP_T37 and HUMRAPl G AP_T41. Table 5060 below describes the starting and ending position of this segment on each transcript.

Table 5060 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMRAP 1GAP_P46, HUMRAP 1GAP_P3, HUMRAP 1GAP_P 16, HUMRAP1GAP_P24, HUMRAP 1GAP_P25 and HUMRAP 1GAP_P29.

DESCRIPTION FOR CLUSTER M62096

Cluster M62096 features 7 transcript(s) and 40 segment(s) of interest, the names fcr which are given in Tables 5061 and 5062, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5063.

Table 5061 - Transcripts of interest

Transcript Name

M62096 PEA 1 T4

M62096 PEA 1 T5

M62096 PEA 1 T6

M62096 PEA 1 T7

M62096 PEA 1 X₉

M62096 PEA 1 T13

M62096 PEA 1 T14

Table 5062 - Segments of interest

Segment Name

M62096 PEA 1 node 0

M62096 PEA 1 node 2

M62096 PEA 1 node 15

M62096 PEA 1 node 17

M62096 PEA 1 node 19

M62096 PEA 1 node 23

M62096 PEA 1 node 27

M62096 PEA 1 node 29

M62096 PEA 1 node 31

M62096 PEA 1 node 34

M62096 PEA 1 node 36

M62096 PEA 1 node 38

M62096 PEA 1 node 40

M62096 PEA 1 node 48 M62096 PEA 1 node 60

M62096 PEA 1 node 65

M62096 PEA 1 node 69

M62096 PEA 1 node 71

M62096 PEA 1 node 1

M62096 PEA 1 node 4

M62096 PEA 1 node 6

M62096 PEA 1 node 7

M62096 PEA 1 node 9

M62096 PEA 1 _node_ 11

M62096 PEA 1 node 13

M62096 PEA 1 node 21

M62096 PEA 1 node 25

M62096 PEA 1 node 33

M62096 PEA 1 node 42

M62096 PEA 1 node 44

M62096 PEA 1 node 47

M62096 PEA 1 node 51

M62096 PEA 1 node 53

M62096 PEA 1 node 55

M62096 PEA 1 node 58

M62096 PEA 1 node 62

M62096 PEA 1 node 66

M62096 PEA 1 node 67

M62096 PEA 1 node 68

M62096 PEA 1 node 70

Table 5063 - Proteins of interest

These sequences are variants of the known protein Kinesin heavy chain isoform 5C (SwissProt accession identifier KF5C_HUMAN; known also according to the synonyms Kinesin heavy chain neuron- specific 2), referred to herein as the previously known protein. Protein Kinesin heavy chain isoform 5C is known or believed to have the following function(s): Kinesin is a microtubule- associated force-producing protein that may play a role in organelle transport. The sequence for protein Kinesin heavy chain isoform 5C is given at the end of the application, as "Kinesin heavy chain isoform 5C amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5064.

Table 5064 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: organelle organization and biogenesis, which are annotation(s) related to Biological Process; microtubule motor; ATP binding, which are annotation(s) related to Molecular Function; and kinesin, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster M62096 features 40 segment(s), which were listed in Table 5062 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M62096_PEA_l_node_0 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5065 below describes the starting and ending position of this segment on each transcript.

Table 5065 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096_PEA_l_P8 and M62096JPEAJJP9.

Segment cluster M62096_PEA_l_node_2 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5066 below describes the starting and ending position of this segment on each transcript. Table 5066 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096_PEA_l_P8 and M62096_PEA_l_P9.

Segment cluster M62096_PEA_l_node_15 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096JPEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5067 below describes the starting and ending position of this segment on each transcript.

Table 5067 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1_P11,

M62096_PEA_l_P12, M62O96_PEA_1J^>8 and M62096_PEA_l_P9.

Segment cluster M62096_PEA_l_node_17 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T7. Table 5068 below describes the starting and ending position of this segment on each transcript.

Table 5068 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62096_PEA_l_P5.

Segment cluster M62096_PEA_l_node_19 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T6 and M62096_PEA_l_T9. Table 5069 below describes the starting and ending position of this segment on each transcript.

Table 5069 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62096_PEA_l_P3. This segment can also be found in the following protein(s): M62096_PEA_l JP4, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_23 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7, M62096_PEA_l_T9, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5070 below describes the starting and ending position of this segment on each transcript.

Table 5070 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62096_PEA_l_P3. This segment can also be found in the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096_PEA_l_P4, M62096JPEAJ _JP5, M62096_PEA_l_P8 and M62096_PEA_l_P9, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_27 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l _T5, M62096_PEA_l_T6, M62096_PEA_l_T7, M62096JPEA_l_T9, M62096_PEA_l_T13 and M62096JPEA_l_T14. Table 5071 below describes the starting and ending position of this segment on each transcript.

Table 5071 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P4, M62096_PEA_l_P5, M62096_PEA__l_P3, M62096_PEA_l_P8 and M62096_PEA_l_P9, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_29 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4. Table 5072 below describes the starting and ending position of this segment on each transcript.

Table 5072 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1_P11. Segment cluster M62096_PEA_l_node_31 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_ l_T5, M62096_PEA_l_T6, M62O96_PEA_1_T7, M62096_PEA_l_T9, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5073 below describes the starting and ending position of this segment on each transcript.

Table 5073 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096JPEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l J^>5, M62096_PEA_l_P3, M62096_PEA_l_P8 and M62096_PEA_l_P9, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_34 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T14. Table 5074 below describes the starting and ending position of this segment on each transcript. Table 5074 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1JP9. Segment cluster M62096_PEA_l_node_36 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l _T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7, M62096_PEA_l_T9 and M62096_PEA_l_T13. Table 5075 below describes the starting and ending position of this segment on each transcript.

Table 5075 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5, M62096_PEA_l_P3 and M62096_PEA_l_P8, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_ l_node_38 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096JPEA_l_T6, M62096_PEA_l_T7, M62096_PEA_l_T9 and M62096_PEA_l_T13. Table 5076 below describes the starting and ending position of this segment on each transcript.

Table 5076 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5, M62096_PEA_l_P3 and M62096_PEA_lJP8, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_40 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l__T7, M62096_PEA_l_T9 and M62096_PEA_l_T13. Table 5077 below describes the starting and ending position of this segment on each transcript.

Table 5077 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096JPEA__l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5, M62096_PEA_l_P3 and M62096_PEA_l_P8, since it is in the coding region for the corresponding transcript. Segment cluster M62096_PEA_l_node_48 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T13. Table 5078 below describes the starting and ending position of this segment on each transcript.

Table 5078 - Segment location on transcripts

This segment can be found in the following protein(s): M62096_PEA_l_P8.

Segment cluster M62096_PEA_l_node_60 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096JPEA_ l_T5, M62096JPEA_l_T6, M62096_PEA_l_T7 and M62096_JPEA_l_T9. Table 5079 below describes the starting and ending position of this segment on each transcript.

Table 5079 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5 and M62096JPEA_l_P3, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_65 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096JPEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7 and M62096__PEA_l_T9. Table 5080 below describes the starting and ending position of this segment on each transcript.

Table 5080 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62O96_PEA_1JP4, M62096 PEA 1 P5 and M62096 PEA 1 P3.

Segment cluster M62096_PEA_l_node_69 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7 and M62096_PEA_l_T9. Table 5081 below describes the starting and ending position of this segment on each transcript.

Table 5081 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11, M62096JPEAJJP12, M62096_PEA_l_P4, M62096 PEA 1 P5 and M62096 PEA 1 P3. Segment cluster M62096_PEA_l_node_71 according to the present invention is supported by 178 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096JPEA_l_T7 and M62096_PEA_l_T9. Table 5082 below describes the starting and ending position of this segment on each transcript.

Table 5082 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1JP11, M62096_PEA_l_P12, M62096_PEA_l_P4, M62096 PEA 1 P5 and M62096 PEA 1 P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M62096_PEA_l_node_l according to the present invention can be found in the following transcript(s): M62096_PEA_ l_T4, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5083 below describes the starting and ending position of this segment on each transcript.

Table 5083 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 , M62096_PEA_l_P8 and M62096_PEA_l_P9.

Segment cluster M62096_PEA_l_node_4 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5084 below describes the starting and ending position of this segment on each transcript. Table 5084 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096_PEA_l_P8 and M62096_PEA_l_P9.

Segment cluster M62096_PEA_l_node_6 according to the present invention is supported by 13 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5085 below describes the starting and ending position of this segment on each transcript.

Table 5085 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1_P1 1, M62096_PEA_l_P12, M62096_PEA_l_P8 and M62096_PEA_l_P9.

Segment cluster M62096_PEA_l_node_7 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5086 below describes the starting and ending position of this segment on each transcript.

Table 5086 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096_PEA_l_P8 and M62096_PEA_l_P9.

Segment cluster M62096_PEA_l_node_9 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5087 below describes the starting and ending position of this segment on each transcript.

Table 5087 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1_P11, M62096JPEA_l_P12, M62096_PEA_l_P8 and M62096_PEA_l_P9. Segment cluster M62096_PEA_l_node_l 1 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096JPEA_l_T5, M62096_PEA_l_T13 arri M62096_PEA_l_T14. Table 5088 below describes the starting and ending position of this segment on each transcript.

Table 5088 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1_P11, M62096 PEA_1_P12, M62096 PEA_1_P8 and M62096 PEA_1 P9.

Segment cluster M62096_PEA_l_node_13 according to the present invention is supported by 24 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5089 below describes the starting and ending position of this segment on each transcript.

Table 5089 - Segment location on transcripts

This segment can be found in the following protein(s): M62O96_PEA_1JP11, M62096_PEA_l_P12, M62096_PEA_l_P8 and M62096_PEA_l_P9. Segment cluster M62096_PEA_l_node_21 according to the present invention is supported by 33 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7, M62096_PEA_l_T9, M62096_PEA_l_T13 and M62096_PEA_l_T14. Table 5090 below describes the starting and ending position of this segment on each transcript.

Table 5090 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62096_PEA_l_P5 and M62096_PEA_l_P3. This segment can also be found in the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096JPEAJ JP4, M62096_PEA_l_P8 and M62096_PEA_l_P9, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_25 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T5 and M62096_PEA_l_T9. Table 5091 below describes the starting and ending position of this segment on each transcript.

Table 5091 - Segment location on transcripts

M62096 PEA 1 T9 380 440

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62096JPEA_l_P3. This segment can also be found in the following protein(s): M62096_PEA_l_P12, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_33 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7, M62096J^>EA_l_T9, M62096_JPEA_l_T13 and M62096_PEA_l_T14. Table 5092 below describes the starting and ending position of this segment on each transcript.

Table 5092 - Segment location on transcripts

This segment can be found in both coding and non- coding regions oftranscript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5, M62096_PEA_l_P3, M62096_PEA_l_P8 and M62096_PEA_l_P9, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_42 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7, M62096_PEA_l_T9 and M62096_PEA_l_T13. Table 5093 below describes the starting and ending position of this segment on each transcript.

Table 5093 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5, M62096_PEA_l_P3 and M62096_PEA_l_P8, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_44 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7, M62096_PEA_l_T9 and M62096_PEA_l_T13. Table 5094 below describes the starting and ending position of this segment on each transcript.

Table 5094 - Segment location on transcripts

This segment can be found m both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5, M62096_PEA_l_P3 and M62096_PEA_l_P8, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_47 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096JPEA_l_T6, M62096_PEA_l_T7, M62096_PEA_l_T9 and M62096JPEA_l__T13. Table 5095 below describes the starting and ending position of this segment on each transcript.

Table 5095 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5096.

Table 5096 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5, M62096_PEA_l_P3 and M62096_PEA_l_P8, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_51 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7 and M62096_PEA_l _T9. Table 5097 below describes the starting and ending position of this segment on each transcript.

Table 5097 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of trans cript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5 and

M62096_PEA_l_P3, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_53 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7 and M62096_PEA_l_T9. Table 5098 below describes the starting and ending position of this segment on each transcript.

Table 5098 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l JP12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62O96JPEA_1JP5 and M62096_PEA_l_P3, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_55 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096 PEAJ T6, M62096_PEA_l_T7 and M62096_PEA_l_T9. Table 5099 below describes the starting and ending position of this segment on each transcript.

Table 5099 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096JPEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA__l_P4, M62096_PEA_l_P5 and M62096_PEA_l_P3, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_58 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096JPEA_l_T4, M62096_PEA_l _T5, M62096JPEA_l_T6, M62096JPEA_l_T7 and M62096_PEA_l_T9. Table 5100 below describes the starting and ending position of this segment on each transcript.

Table 5100 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62096_PEA_l_Pl 1 and M62096JPEA_l_P12. This segment can also be found in the following protein(s): M62096_PEA_l_P4, M62096_PEA_l_P5 and M62096_PEA_l_P3, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_62 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7 and M62096_PEA_l_T9. Table 5101 below describes the starting and ending position of this segment on each transcript.

Table 5101 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11 and M62096_PEA_l_P12. This segment can also be found in the following protein(s): M62096__PEA_l_P4, M62096_PEAJ_P5 and M62096_PEA_l_P3, since it is in the coding region for the corresponding transcript.

Segment cluster M62096_PEA_l_node_66 according to the present invention is supported by 23 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7 and M62096_PEA_l_T9. Table 5102 below describes the starting and ending position of this segment on each transcript.

Table 5102 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1JP11, M62096_PEA_l_P12, M62096_PEA_l_P4, M62096_PEA_l_P5 and M62096_PEA_l_P3.

Segment cluster M62096_PEA_l_node_67 according to the present invention can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_ l_T7 and M62096_PEA_l_T9. Table 5103 below describes the starting and ending position of this segment on each transcript.

Table 5103 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096JPEAJ JP4, M62096 PEA 1 P5 and M62096 PEA 1 P3.

Segment cluster M62096JPEA_l_node_68 according to the present invention can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7 and M62096_PEA_l_T9. Table 5104 below describes the starting and ending position of this segment on each transcript. Table 5104 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096_PEA_l_P4, M62096_PEA_l_P5 and M62O96JPEA_1JP3.

Segment cluster M62096_PEA_l_node_70 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62096_PEA_l_T4, M62096_PEA_l_T5, M62096_PEA_l_T6, M62096_PEA_l_T7 and M62096_PEA_l_T9. Table 5105 below describes the starting and ending position of this segment on each transcript.

Table 5105 - Segment location on transcripts

M62096 PEA 1 _T9 | 4737 | 4791 |

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62O96_PEA_1_P11, M62096_PEA_l_P12, M62096_PEA_l_P4, M62096_PEA_l_P5 and M62096_PEA_l_P3.

Expression of Kinesin heavy chain isoform 5C M62096 transcripts which are detectable by amplicon as depicted in sequence name M62096 segl9 in normal and cancerous lung tissues

Expression of Kinesin heavy chain isoform 5C transcripts detectable by or according to M62096 segl9, M62096 segl9 amplicon(s) and M62096 segl9F and M62096 segl9R primers was measured by real time PCR. In parallel the expression of four housekeeping genes -PBGD (GenBank Accession No. BCOl 9323; amplicon - PBGD-amplicon), HPRTl (GenBank Accession No. NM_000194; amplicon - HPRTl -amplicon), Ubiquitin (GenBank Accession No. BC000449; amplicon - Ubiquitin- amplicon) and SDHA (GenBank Accession No. NM_004168; amplicon — SDHA- amplicon) was measured similarly. For each RT sample, the expression of the above amplicon was normalized to the geometric mean of the quantities of the housekeeping genes. The normalized quantity of each RT sample was then divided by the median of the quantities of the normal post-mortem (PM) samples (Sample Nos. 47-50, 90-93, 96-99, Table 1, above), to obtain a value of fold up -regulation for each sample relative to median of the normal PM samples.

Figure 123 is a histogram showing over expression of the above- indicated KINESIN

HEAVY CHAIN ISOFORM 5 C transcripts in cancerous lung samples relative to the normal samples. Values represent the average of duplicate experiments. Error bars indicate the minimal and maximal values obtained. As is evident from Figure 123, the expression of KINESIN HEAVY CHAIN ISOFORM

5 C transcripts detectable by the above amplicon(s) in cancer samples was significantly higher than in the non-cancerous samples (Sample Nos. 47-50, 90-93, 96-99 Table 1). Notably an over-expression of at least 5 fold was found in.2 out of 15 adenocarcinoma samples, and in 8 out of 8 small cell carcinoma samples. Primer pairs are also optionally and preferably encompassed within the present invention; for example, for the above experiment, the following primer pair was used as a non- limiting illustrative example only of a suitable primer pair: M62096 segl9F forward primer; and M62096 segl9R reverse primer. The present invention also preferably encompasses any amplicon obtained through the use of any suitable primer pair; for example, for the above experiment, the following amplicon was obtained as a non- limiting illustrative example only of a suitable amplicon: M62096 segl9.

Forward primer -M62096 segl9F: GCTGATTGTCCCCATGAAGG

Reverse primer- M62096 segl9: TGGCATACGGGAACTCAGTG Amplicon:

GCTGATTGTCCCCATGAAGGCCAGCCTTGAAGCTTGGTCAGTCTCCCTAACTGTATG ATTGATCCCCACTTATTGCACTACATCACTGAGTTCCCGTATGC

Figure 1 :

Cluster M62117 features 2 trans cript(s) and 24 segment(s) of interest, the names for which are given in Tables 5061 and 5062, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5063.

Table 5106 - Transcripts of interest

Table 5107 - Segments of interest

SegmentName

M62117 node 0

M62117 node 5

M62117 node 9

M62117 node 10

M62117 node 12

M62117 node 15

M62117 node 16

M62117 node 18 M62117 node 20

M621 17 node 23

M621 17 node 25

M621 17 node 26

M621 17 node 28

M621 17 node 29

M621 17 node 2

M62117 node 4

M621 17 node 7

M62117_node 13

M621 17 node 17

M621 17 node 21

M621 17 node 22

M621 17 node 24

M621 17 node 27

M621 17 node 30

Table 5108 - Proteins of interest

These sequences are variants of the known protein Complexin 2 (SwissProt accession identifier CLX2_HUMAN; known also according to the synonyms Synaphin 1; 921 -L), referred to herein as the previously known protein.

Protein Complexin 2 is known or believed to have the following function(s): Functions in synaptic vesicle exocytosis. Associated with the docking/fusion complex crucial to transmitter release. Regulate the sequential interactions of alpha-snap and synaptotagmins with the snap receptor during exocytosis. Binds syntaxin. The sequence for protein Complexin 2 is given at the end of the application, as "Complexin 2 amino acid sequence".

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: neurotransmitter transport; non- selective vesicle docking; membrane fusion; vacuole organization and biogenesis, which are annotation(s) related to Biological Process; and SNARE binding, which are annotation(s) related to Molecular Function.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster M62117 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 124 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 124 and Table 5064. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: lung malignant tumors.

Table 5109 - Normal tissue distribution

Table 5110 - P values and ratios for expression in cancerous tissue

As noted above, cluster M62117 features 24 segment(s), which were listed in Table 5062 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M62117_node_0 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5066 below describes the starting and ending position of this segment on each transcript.

Table 5111 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_5 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T12. Table 5067 below describes the starting and ending position of this segment on each transcript.

Table 5112 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P3.

Segment cluster M62117_node_9 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3 and M62117_T12. Table 5068 below describes the starting and ending position of this segment on each transcript.

Table 5113 - Segment location on transcripts

This segment can be found in the following protein(s): M62117JP4 and M62117_P3.

Segment cluster M62117__node_10 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T12. Table 5069 below describes the starting and ending position of this segment on each transcript.

Table 5114 - Segment location on transcripts

This segment can be found in the following protein(s): M62117_P3.

Segment cluster M62117_node_12 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5070 below describes the starting and ending position of this segment on each transcript. v

Table 5115 - Segment location on transcripts

This segment can be found in the following protein(s): M62117_P4.

Segment cluster M62117_node_15 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5071 below describes the starting and ending position of this segment on each transcript.

Table 5116 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_16 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5072 below describes the starting and ending position of this segment on each transcript.

Table 5117 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_18 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5073 below describes the starting and ending position of this segment on each transcript.

Table 5118 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_20 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5074 below describes the starting and ending position of this segment on each transcript.

Table 5119 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_23 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5075 below describes the starting and ending position of this segment on each transcript.

Table 5120 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4. Segment cluster M62117_node_25 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5076 below describes the starting and ending position of this segment on each transcript.

Table 5121 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_26 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5077 below describes the starting and ending position of this segment on each transcript.

Table 5122 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_28 according to the present invention is supported by 97 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5078 below describes the starting and ending position of this segment on each transcript.

Table 5123 - Segment location on transcripts

M62117 T3 3890 4232

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M 62117_node_29 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5079 below describes the starting and ending position of this segment on each transcript.

Table 5124 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M62117_node_2 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5080 below describes the starting and ending position of this segment on each transcript.

Table 5125 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4. Segment cluster M62117_node_4 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T12. Table 5081 below describes the starting and ending position of this segment on each transcript.

Table 5126 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P3.

Segment cluster M62117_node_7 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3 and M62117_T12. Table 5082 below describes the starting and ending position of this segment on each transcript.

Table 5127 - Segment location on transcripts

This segment can be found in the following protein(s): M62117_P4 and M62117_P3.

Segment cluster M62117_node_13 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5083 below describes the starting and ending position of this segment on each transcript.

Table 5128 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_17 according to the present invention can be found in the following transcript(s): M62117_T3. Table 5084 below describes the starting and ending position of this segment on each transcript.

Table 5129 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_21 according to the present invention can be found in the following transcript(s): M62117_T3. Table 5085 below describes the starting and ending position of this segment on each transcript.

Table 5130 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_22 according to the present invention can be found in the following transcript(s): M62117_T3. Table 5086 below describes the starting and ending position of this segment on each transcript.

Table 5131 - Segment location on transcripts

This segment can be found in a non-coding region of transcπpt(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_24 according to the present invention can be found in the following transcript(s): M62117_T3. Table 5087 below describes the starting and ending position of this segment on each transcript.

Table 5132 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_27 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5088 below describes the starting and ending position of this segment on each transcript.

Table 5133 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62117_P4.

Segment cluster M62117_node_30 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62117_T3. Table 5089 below describes the starting and ending position of this segment on each transcript.

Table 5134 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62117_P4.

DESCRIPTION FOR CLUSTER M62189

Cluster M62189 features 11 transcript(s) and 35 segment(s) of interest, the names for which are given in Tables 5135 and 5136, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5137.

Table 5135 - Transcripts of interest

Transcript Name

M62189 T2

M62189 T4

M62189 T12

M62189 T15

M62189 T19

M62189 T22

M62189 T23

M62189 T24

M62189 T25

M62189. _T27

M62189 T28

Table 5136 - Segments of interest

Table 5137 - Proteins of interest

These sequences are valiants of the known protein Asparaginyl-tRNA synthetase, cytoplasmic (SwissProt accession identifier SYNJHUMAN; known also according to the synonyms EC 6.1.1.22; Asparagine— fRNA ligase; AsnRS), referred to herein as the previously known protein.

The sequence for protein Asparaginyl-tRNA synthetase, cytoplasmic is given at the end of the application, as "Asparaginyl-tRNA synthetase, cytoplasmic amino acid sequence". Protein Asparaginyl-tRNA synthetase, cytoplasmic localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: asparagine-tRNA ligase, which are annotation(s) related to Molecular Function; and soluble fraction; cytoplasm, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster M62189 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 125 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 125 and Table 5138. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: uterine malignancies.

Table 5138 - Normal tissue distribution

Table 5139 - P values and ratios for expression in cancerous tissue

As noted above, cluster M62189 features 35 segment(s), which were listed in Table 5136 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M62189_node_0 according to the present invention is supported by 139 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T22 and M62189_T27. Table 5140 below describes the starting and ending position of this segment on each transcript.

Table 5140 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189_P 16 and M62189_P 19.

Segment cluster M 62189_node_4 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T28. Table 5141 below describes the starting and ending position of this segment on each transcript.

Table 5141 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62189_P20.

Segment cluster M62189_node_6 according to the present invention is supported by 168 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T22, M62189_T27 and M62189_T28. Table 5142 below describes the starting and ending position of this segment on each transcript.

Table 5142 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189_P16, M62189_P19 and M62189_P20. Segment cluster M62189_node__l 1 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T19. Table 5143 below describes the starting and ending position of this segment on each transcript.

Table 5143 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P13.

Segment cluster M62189_node_23 according to the present invention is supported by 143 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5144 below describes the starting and ending position of this segment on each transcript.

Table 5144 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189_P13 and M62189_P16.

Segment cluster M62189_node_25 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5145 below describes the starting and ending position of this segment on each transcript.

Table 5145 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P3. This segment can also be found in the following protein(s): M62189_P2, M62189_P4, M62189_P13 and M62189_P16, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_27 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T4, M62189_T12 and M62189_T15. Table 5146 below describes the starting and ending position of this segment on each transcript.

Table 5146 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P3. This segment can also be found in the following protein(s): M62189_P4, since it is in the coding region for the corresponding transcript. Segment cluster M62189_node_34 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T23, M62189_T24 and M62189_T25. Table 5147 below describes the starting and ending position of this segment on each transcript.

Table 5147 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62189JP17.

Segment cluster M62189_node_36 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T23, M62189_T24 and M62189_T25. Table 5148 below describes the starting and ending position of this segment on each transcript.

Table 5148 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62189_P17.

Segment cluster M62189_node_37 according to the present invention is supported by 171 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T22, M62189_T23, M62189_T24 and M62189_T25. Table 5149 below describes the starting and ending position of this segment on each transcript.

Table 5149 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P2, M62189_P13, M62189_P16 and M62189_P17, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_38 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T15 and M62189_T25. Table 5150 below describes the starting and ending position of this segment on each transcript.

Table 5150 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P4. This segment can also be found in the following protein(s): M62189_P2, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_46 according to the present invention is supported by 405 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T23, M62189_T24 and M62189_T25. Table 5151 below describes the starting and ending position of this segment on each transcript.

Table 5151 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P2, M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189JH3 and M62189_P17, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_48 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T22. Table 5152 below describes the starting and ending position of this segment on each transcript.

Table 5152 - Segment location on transcripts

I M62189_T22 | I 1923 I I 2560 I

This segment can be found in the following protein(s): M62189_P16.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M62189jnode_2 according to the present invention is supported by 151 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T22 and M62189_T27. Table 5153 below describes the starting and ending position of this segment on each transcript.

Table 5153 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189JP16 and M62189_P19.

Segment cluster M62189_node_5 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T28. Table 5154 below describes the starting and ending position of this segment on each transcript.

Table 5154 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P20.

Segment cluster M62189_node_8 according to the present invention is supported by 144 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T22, M62189JI27 and M62189_T28. Table 5155 below describes the starting and ending position of this segment on each transcript.

Table 5155 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4, M62189JP3, M62189_P16, M62189_P19 and M62189_P20.

Segment cluster M62189_node_9 according to the present invention can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T22, M62189_T27 and M62189_T28. Table 5156 below describes the starting and ending position of this segment on each transcript.

Table 5156 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189_P16, M62189_P19 and M62189_P20.

Segment cluster M62189_node_12 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T22, M62189_T27 and M62189_T28. Table 5157 below describes the starting and ending position of this segment on each transcript.

Table 5157 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P13. This segment can also be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189_P16, M62189_P19 and M62189_P20, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_13 according to the present invention is supported by 135 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T22, M62189_T27 and M62189_T28. Table 5158 below describes the starting and ending position of this segment on each transcript.

Table 5158 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P13. This segment can also be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189_P16, M62189_P19 and M62189_P20, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_15 according to the present invention is supported by 136 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T22, M62189_T27 and M62189_T28. Table 5159 below describes the starting and ending position of this segment on each transcript.

Table 5159 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189JM, M62189_P3, M62189_P13, M62189_P16, M62189_P19 and M62189_P20.

Segment cluster M62189_node_16 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T27 and M62189_T28. Table 5160 below describes the starting and ending position of this segment on each transcript.

Table 5160 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P19 and M62189_P20.

Segment cluster M62189_node_18 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189 J2, M62189_T4, M62189_T12, M62189_T15,

M62189_T19 and M62189_T22. Table 5161 below describes the starting and ending position of this segment on each transcript.

Table 5161 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4,

M62189_P3, M62189_P13 and M62189_P16. Segment cluster M62189_node_l 9 according to the present invention is supported by 128 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5162 below describes the starting and ending position of this segment on each transcript.

Table 5162 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189_P13 and M62189_P16.

Segment cluster M62189_node_22 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5163 below describes the starting and ending position of this segment on each transcript.

Table 5163 - Segment location on transcripts

This segment can be found in the following protein(s): M62189_P2, M62189_P4, M62189_P3, M62189_P13 and M62189_P16. Segment cluster M62189_node_24 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T12. Table 5164 below describes the starting and ending position of this segment on each transcript.

Table 5164 - Segment location on transcripts

This segment can be found in the following protein(s): M62189 P3.

Segment cluster M62189_node_26 according to the present invention can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5165 below describes the starting and ending position of this segment on each transcript.

Table 5165 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P3. This segment can also be found in the following protein(s): M62189_P2, M62189JP4, M62189_P13 and M62189_P16, since it is in the coding region for the corresponding transcript. Segment cluster M62189_node_28 according to the present invention can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5166 below describes the starting and ending position of this segment on each transcript.

Table 5166 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P2, M62189_P13 and M62189_P16, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_29 according to the present invention can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5167 below describes the starting and ending position of this segment on each transcript.

Table 5167 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P2, M62189JM3 and M62189_P16, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_30 according to the present invention is supported by 140 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5168 below describes the starting and ending position of this segment on each transcript.

Table 5168 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P2, M62189_P13 and M62189_P16, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_32 according to the present invention is supported by 148 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19 and M62189_T22. Table 5169 below describes the starting and ending position of this segment on each transcript. Table 5169 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P2, M62189_P13 and M62189JP16, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_35 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T23 and M62189_T25. Table 5170 below describes the starting and ending position of this segment on each transcript.

Table 5170 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62189_P17.

Segment cluster M62189jnode_39 according to the present invention can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T22, M62189_T23, M62189_T24 and M62189_T25. Table 5171 below describes the starting and ending position of this segment on each transcript. Table 5171 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P2, M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P13, M62189_P16 and M62189_P17, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_40 according to the present invention is supported by 161 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T22, M62189_T23, M62189_T24 and M62189_T25. Table 5172 below describes the starting and ending position of this segment on each transcript.

Table 5172 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P2, M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P13, M62189_P16 and M62189_P17, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_41 according to the present invention is supported by 166 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T22, M62189_T23, M62189_T24 and M62189_T25. Table 5173 below describes the starting and ending position of this segment on each transcript.

Table 5173 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P2, M62189JP4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P13, M62189_P16 and M62189_P17, since it is in the coding region for the corresponding transcript.

Segment cluster M62189_node_45 according to the present invention is supported by 170 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62189_T2, M62189_T4, M62189_T12, M62189_T15, M62189_T19, M62189_T22, M62189_T23, M62189_T24 and M62189_T25. Table 5174 below describes the starting and ending position of this segment on each transcript.

Table 5174 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62189_P2, M62189_P4 and M62189_P3. This segment can also be found in the following protein(s): M62189_P13, M62189_P16 and M62189_P17, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER M62246

Cluster M62246 features 5 transcript(s) and 12 segment(s) of interest, the names for which are given in Tables 5175 and 5176, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5177.

Table 5175 - Transcripts of interest

Transcript Name

M62246 T6

M62246 T7 M62246 T8

M62246 T9

M62246 T12

Table 5176 - Segments of interest

Segment Name

M62246 node 4

M62246 node 5

M62246 node 9

M62246 node 11

M62246 node 13

M62246 node 17

M62246 node 18

M62246 node 24

M62246 node 26

M62246 node 7

M62246 node 15

M62246 node 22

Table 5177 - Proteins of interest

Cluster M62246 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 126 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 126 and Table 5178. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors. Table 5178 - Normal tissue distribution

Table 5179 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 5180. Table 5180 - Oligonucleotides related to this cluster

As noted above, cluster M62246 features 12 segment(s), which were listed in Table 5176 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M62246_node_4 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T6, M62246_T7, M62246_T8, M62246_T9 and M62246_T12. Table 5181 below describes the starting and ending position of this segment on each transcript. Table 5181 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62246_P3, M62246_P4 and M62246_P6.

Segment cluster M62246_node_5 according to the present invention is supported by 6 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M62246_T8. Table 5182 below describes the starting and ending position of this segment on each transcript.

Table 5182 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62246_P3.

Segment cluster M62246_node_9 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T8. Table 5183 below describes the starting and ending position of this segment on each transcript.

Table 5183 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62246_P3.

Segment cluster M62246_node_l 1 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T6. Table 5184 below describes the starting and ending position of this segment on each transcript.

Table 5184 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62246JP3.

Segment cluster M62246_node_13 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T6, M62246_T7, M62246_T8, M62246_T9 and M62246_T12. Table 5185 below describes the starting and ending position of this segment on each transcript.

Table 5185 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62246_P3. This segment can also be found in the following protein(s): M62246_P4 and M62246_P6, since it is in the coding region for the corresponding transcript.

Segment cluster M62246_node_17 according to the present invention is supported by 57 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M62246_T6, M62246_T7, M62246_T8, M62246_T9 and M62246_T12. Table 5186 below describes the starting and ending position of this segment on each transcript.

Table 5186 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62246_P4. This segment can also be found in the following protein(s): M62246_P3 and M62246_P6, since it is in the coding region for the corresponding transcript.

Segment cluster M62246_node_l 8 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T9. Table 5187 below describes the starting and ending position of this segment on each transcript.

Table 5187 ~ Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62246_P4.

Segment cluster M62246_node_24 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T6, M62246_T7 and M62246_T8. Table 5188 below describes the starting and ending position of this segment on each transcript.

Table 5188 - Segment location on transcripts

This segment can be found in the following protein(s): M62246_P3.

Segment cluster M62246_node_26 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T12. Table 5189 below describes the starting and ending position of this segment on each transcript.

Table 5189 - Segment location on transcripts

This segment can be found in the following protein(s): M62246_P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M62246_node_7 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T6, M62246_T7, M62246_T8, M62246_T9 and M62246_T12. Table 5190 below describes the starting and ending position of this segment on each transcript.

Table 5190 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62246_P3. This segment can also be found in the following protein(s): M62246_P4 and M62246_P6, since it is in the coding region for the corresponding transcript.

Segment cluster M62246_node_15 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T7 and M62246_T9. Table 5191 below descπbes the starting and ending position of this segment on each transcript.

Table 5191 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62246_P3. This segment can also be found in the following protein(s): M62246_P4, since it is in the coding region for the corresponding transcript.

Segment cluster M62246_node_22 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62246_T6, M62246_T7, M62246_T8 and M62246_T12. Table 5192 below describes the starting and ending position of this segment on each transcript.

Table 5192 - Segment location on transcripts

This segment can be found in the following protein(s): M62246_P3 and M62246_P6.

DESCRIPTION FOR CLUSTER M78001

Cluster M78001 features 5 transcript(s) and 35 segment(s) of interest, the names for which are given in Tables 5193 and 5194, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5195.

Table 5193 - Transcripts of interest

Transcript Name

M78001 T13

M78001 T17

M78001 T18

M78001 T21

M78001 T59

Table 5194 - Segments of interest

M78001 node 6

M78001 node 12

M78001 node 15

M78001 node 19

M78001 node 21

M78001 node 23

M78001 node 58

M78001 node 63

M78001 node 67

M78001_node 71

M78001 node 74

M78001 node 77

M78001 node 78

M78001 node 83

M78001 node 84

M78001 node 88

M78001 node 89

M78001 node 91

M78001 node 96

M78001 node 97

M78001 node 100

M78001 node 101

M78001 node 102

Table 5195 - Proteins of interest

These sequences are variants of the known protein T-cell surface glycoprotein E2 precursor (SwissProt accession identifier MIC2_HUMAN; known also according to the synonyms E2 antigen; CD99 antigen; MIC2 protein; 12E7), referred to herein as the previously known protein.

Protein T-cell surface glycoprotein E2 precursor is known or believed to have the following function(s): Involved in T-cell adhesion processes. It is involved in spontaneous rosette formation with erythrocytes. The sequence for protein T-cell surface glycoprotein E2 precursor is given at the end of the application, as "T-cell surface glycoprotein E2 precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5196.

Table 5196 - Amino acid mutations for Known Protein

Protein T-cell surface glycoprotein E2 precursor localization is believed to be Type I membrane protein (Potential).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cytoplasm; integral plasma membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslmk, available from ^ttp^/www.ncbi.nlm.nih.gov/projects/LocusLinl^.

Cluster M78001 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 127 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 127 and Table 5197. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors.

Table 5197 - Normal tissue distribution

Table 5198 - P values and ratios for expression in cancerous tissue

As noted above, cluster M78001 features 35 segment(s), which were listed in Table 5194 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M78001_node_0 according to the present invention is supported by 2 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5199 below describes the starting and ending position of this segment on each transcript.

Table 5199 - Segment location on transcripts

This segment can be found in the following protein(s): M78001JP21.

Segment cluster M78001_node_8 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5200 below describes the starting and ending position of this segment on each transcript.

Table 5200 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001JP21.

Segment cluster M78001__node_34 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5201 below describes the starting and ending position of this segment on each transcript.

Table 5201 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001JP21.

Segment cluster M78001_node_50 according to the present invention is supported by 336 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T17, M78001_T18 and M78001_T21. Table 5202 below describes the starting and ending position of this segment on each transcript.

Table 5202 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P7, M78001_P8 and M78001 PlO. Segment cluster M78001_node_66 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13. Table 5203 below describes the starting and ending position of this segment on each transcript.

Table 5203 - Segment location on transcripts

This segment can be found in the following protein(s): M78001 JP6.

Segment cluster M78001_node_92 according to the present invention is supported by 14 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M78001_T17 and M78001_T21. Table 5204 below describes the starting and ending position of this segment on each transcript.

Table 5204 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78001JP7 andM78001_P10.

Segment cluster M78001_node_95 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T18. Table 5205 below describes the starting and ending position of this segment on each transcript.

Table 5205 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P8.

Segment cluster M78001_node_103 according to the present invention is supported by 435 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5206 below describes the starting and ending position of this segment on each transcript.

Table 5206 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001_P6, M78001_P7, M78001_P8 and M78001_P10.

Segment cluster M78001_node_104 according to the present invention is supported by 308 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and

M78001_T21. Table 5207 below describes the starting and ending position of this segment on each transcript.

Table 5207 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001_P6, M78001_P7, M78001_P8 and M78001_P10. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M78001_node_l according to the present invention can be found in the following transcript(s): M78001_T59. Table 5208 below describes the starting and ending position of this segment on each transcript.

Table 5208 - Segment location on transcripts

This segment can be found in the following protein(s): M78001 P21.

Segment cluster M78001_node_2 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5209 below describes the starting and ending position of this segment on each transcript.

Table 5209 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P21.

Segment cluster M78001_node_4 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5210 below describes the starting and ending position of this segment on each transcript. Table 5210 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P21.

Segment cluster M78001_node_6 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001 _T59. Table 5211 below describes the starting and ending position of this segment on each transcript.

Table 5211 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001_P21.

Segment cluster M78001_node_12 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5212 below describes the starting and ending position of this segment on each transcript.

Table 5212 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001JP21.

Segment cluster M78001_node_15 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5213 below describes the starting and ending position of this segment on each transcript.

Table 5213 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78001_P21.

Segment cluster M78001_node_19 according to the present invention is supported by 12 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5214 below describes the starting and ending position of this segment on each transcript.

Table 5214 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001JP21.

Segment cluster M78001_node_21 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T59. Table 5215 below describes the starting and ending position of this segment on each transcript.

Table 5215 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001JP21. Segment cluster M78001_node_23 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcπpt(s): M78001_T59. Table 5216 below describes the starting and ending position of this segment on each transcript.

Table 5216 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78001JP21.

Segment cluster M78001_node_58 according to the present invention is supported by 352 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T17, M78001_T18 and M78001_T21. Table 5217 below describes the starting and ending position of this segment on each transcript.

Table 5217 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P7, M78001_P8 and M78001 PlO.

Segment cluster M78001_node_63 according to the present invention is supported by 373 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T17, M78001_T18 and M78001_T21. Table 5218 below describes the starting and ending position of this segment on each transcript.

Table 5218 - Segment location on transcripts

This segment can be found in the following protein(s): M78001JP7, M78001_P8 and M78001_P10.

Segment cluster M78001_node_67 according to the present invention is supported by 398 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5219 below describes the starting and ending position of this segment on each transcript. Table 5219 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P6, M78001_P7, M78001 P8 and M78001 PlO.

Segment cluster M78001_node_71 according to the present invention is supported by 400 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5220 below describes the starting and ending position of this segment on each transcript. Table 5220 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P6, M78001_P7, M78001_P8 and M78001_P10.

Segment cluster M78001_node_74 according to the present invention is supported by 356 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5221 below describes the starting and ending position of this segment on each transcript.

Table 5221 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P6, M78001_P7, M78001 P8 and M78001 PlO.

Segment cluster M78001_node_77 according to the present invention is supported by 341 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5222 below describes the starting and ending position of this segment on each transcript. Table 5222 - Segment location on transcripts

M78001 T21 505 538

This segment can be found in the following protein(s): M78001_P6, M78001_P7, M78001 P8 and M78001 PlO.

Segment cluster M78001_node_78 according to the present invention can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5223 below describes the starting and ending position of this segment on each transcript.

Table 5223 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P6, M78001_P7, M78001 P8 and M78001 PlO.

Segment cluster M78001_node_83 according to the present invention is supported by 386 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5224 below describes the starting and ending position of this segment on each transcript.

Table 5224 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P6, M78001_P7, M78001 P8 and M78001 PlO. Segment cluster M78001_node_84 according to the present invention is supported by 352 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5225 below describes the starting and ending position of this segment on each transcript.

Table 5225 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P6, M78001_P7, M78001 P8 and M78001 PlO.

Segment cluster M78001 jnode_88 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T21. Table 5226 below describes the starting and ending position of this segment on each transcript.

Table 5226 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P10.

Segment cluster M78001_node_89 according to the present invention can be found in the following transcript(s): M78001_T21. Table 5227 below describes the starting and ending position of this segment on each transcript.

Table 5227 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P10.

Segment cluster M78001_node_91 according to the present invention can be found in the following transcript(s): M78001_T17 and M78001_T21. Table 5228 below describes the starting and ending position of this segment on each transcript.

Table 5228 - Segment location on transcripts

This segment can be found in the following protein(s): M78001_P7 and M78001_P10.

Segment cluster M78001_node_96 according to the present invention is supported by 372 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5229 below describes the starting and ending position of this segment on each transcript.

Table 5229 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78001_P7, M78001_P8 and M78001_P10. This segment can also be found in the following protein(s): M78001_P6, since it is in the coding region for the corresponding transcript.

Segment cluster M78001_node_97 according to the present invention can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5230 below describes the starting and ending position of this segment on each transcript.

Table 5230 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78001_P7, M78001_P8 and M78001_P10. This segment can also be found in the following protein(s): M78001_P6, since it is in the coding region for the corresponding transcript.

Segment cluster M78001_node_100 according to the present invention is supported by

387 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5231 below describes the starting and ending position of this segment on each transcript. Table 5231 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78001_P7, M78001_P8 and M78001_P10. This segment can also be found in the following protein(s): M78001_P6, since it is in the coding region for the corresponding transcript.

Segment cluster M78001_node_101 according to the present invention is supported by 404 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5232 below describes the starting and ending position of this segment on each transcript.

Table 5232 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78001_P6, M78001_P7, M78001_P8 and M78001_P10.

Segment cluster M78001_node_102 according to the present invention is supported by 383 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78001_T13, M78001_T17, M78001_T18 and M78001_T21. Table 5233 below describes the starting and ending position of this segment on each transcript.

Table 5233 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78001_P6, M78001_P7, M78001_P8 and M78001_P10.

DESCRIPTION FOR CLUSTER M79217

Cluster M79217 features 4 transcript(s) and 30 seginent(s) of interest, the names for which are given in Tables 5234 and 5235, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5236.

Table 5234 - Transcripts of interest

Transcript Name

M79217 PEA 1 Tl

M79217 PEA 1 T3

M79217 PEA 1 T15

M79217 PEA 1 T18

Table 5235 - Segments of interest

Segment Name

M79217 PEA 1 node 2

M79217 PEA 1 node 4

M79217 PEA 1 node 9

M79217 PEA 1 node 10

M79217 PEA 1 node 11

M79217 PEA 1 node 13

M79217 PEA 1 node 14

M79217 PEA 1 node 16

M79217 PEA 1 node 23

M79217 PEA 1 node 24

M79217 PEA 1 node 31

M79217 PEA 1 node 33

M79217 PEA 1 node 34 M79217 PEA 1 node 35

M79217 PEA 1 node 37

M79217 PEA 1 node 38

M79217 PEA 1 node 41

M79217 PEA 1 node 44

M79217 PEA 1 node 0

M79217 PEA 1 node 7

M79217 PEA 1 node 12

M79217 PEA 1 node 26

M79217_ PEA 1 node 27

M79217 PEA 1 node 30

M79217 PEA 1 node 32

M79217 PEA 1 node 36

M79217 PEA 1 node 39

M79217 PEA 1 node 40

M79217 PEA 1 node 42

M79217 PEA 1 node 43

Table 5236 - Proteins of interest

These sequences are variants of the known protein Exostosin-like 3 (SwissProt accession identifier EXL3JHUMAN; known also according to the synonyms EC 2.4.1.223; Glucuronyl- galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase; Putative tumor suppressor protein EXTL3; Multiple exostosis-like protein 3; Hereditary multiple exostoses gene isolog; EXT-related protein 1), referred to herein as the previously known protein.

Protein Exostosin-like 3 is known or believed to have the following function(s): Probable glycosyltransferase (By similarity). The sequence for protein Exostosin-like 3 is given at the end of the application, as "Exostosin-like 3 amino acid sequence". Protein Exostosin-like 3 localization is believed to be Type II membrane protein. Endoplasmic reticulum. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell growth and/or maintenance, which are annotation(s) related to Biological Process; transferase, transferring glycosyl groups, which are annotation(s) related to Molecular Function; and endoplasmic reticulum; integral membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http ://www.ncbi .nlm .nih.gov/proj ects/LocusLink/> .

As noted above, cluster M79217 features 30 segment(s), which were listed in Table 5235 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M79217_PEA_l_node_2 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T3. Table 5237 below describes the starting and ending position of this segment on each transcript.

Table 5237 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_4 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T15 and M79217_PEA_1_T18. Table 5238 below describes the starting and ending position of this segment on each transcript.

Table 5238 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P8 and M79217_PEA_1_P11.

Segment cluster M79217_PEA_l_node_9 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1. Table 5239 below describes the starting and ending position of this segment on each transcript.

Table 5239 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P 1.

Segment cluster M79217_PEA_l_node_10 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217JPEA_1_T1, M79217_PEA_1_T3, M79217_PEA_1_T15 and M79217_PEA_1_T18. Table 5240 below describes the starting and ending position of this segment on each transcript.

Table 5240 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5241.

Table 5241 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P11. This segment can also be found in the following protein(s): M79217_PEA_1_P1 and M79217_PEA_1_P8, since it is in the coding region for the corresponding transcript.

Segment cluster M79217_PEA_ l_node_l 1 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T15. Table 5242 below describes the starting and ending position of this segment on each transcript.

Table 5242 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1 and M79217 PEA 1 P8. Segment cluster M79217_PEA_l_node_13 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217JPEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T15. Table 5243 below describes the starting and ending position of this segment on each transcript.

Table 5243 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1 and M79217 PEA 1 P8.

Segment cluster M79217_PEA_l_node_14 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T15. Table 5244 below describes the starting and ending position of this segment on each transcript.

Table 5244 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1 and M79217_PEA_1_P8.

Segment cluster M79217_PEA_l_node_16 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T15. Table 5245 below describes the starting and ending position of this segment on each transcript.

Table 5245 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1 and M79217 PEA 1 P8.

Segment cluster M79217_PEA_l_node_23 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T15. Table 5246 below describes the starting and ending position of this segment on each transcript.

Table 5246 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1 and M79217 PEA 1 P8.

Segment cluster M79217_PEA_l_node_24 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T15. Table 5247 below describes the starting and ending position of this segment on each transcript.

Table 5247 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P8.

Segment cluster M79217_PEA_l_node_31 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217_PEA_1_T3. Table 5248 below describes the starting and ending position of this segment on each transcript.

Table 5248 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_ 1_P1.

Segment cluster M79217_PEA_l_node_33 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and

M79217_PEA_ 1_T3. Table 5249 below describes the starting and ending position of this segment on each transcript.

Table 5249 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1. Segment cluster M79217_PEA_l_node_34 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217_PEA_1_T3. Table 5250 below describes the starting and ending position of this segment on each transcript.

Table 5250 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_35 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217_PEA_1_T3. Table 5251 below describes the starting and ending position of this segment on each transcript.

Table 5251 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_37 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1__T1 and M79217_PEA_1_T3. Table 5252 below describes the starting and ending position of this segment on each transcript. Table 5252 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_38 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217_PEA_1_T3. Table 5253 below describes the starting and ending position of this segment on each transcript.

Table 5253 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_41 according to the present invention is supported by 171 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M79217JPEA__1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T18. Table 5254 below describes the starting and ending position of this segment on each transcript

Table 5254 - Segment location on transcripts

M79217 PEA 1 Tl 8 755 1484

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1. This segment can also be found in the following protein(s): M79217_PEA_1_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M79217_PEA_l_node_44 according to the present invention is supported by 89 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T18. Table 5255 below describes the starting and ending position of this segment on each transcript.

Table 5255 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1. This segment can also be found in the following protein(s): M79217_PEA_1_P11, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster M79217_PEA_l_node_0 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T3. Table 5256 below describes the starting and ending position of this segment on each transcript.

Table 5256 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217JPEA_l_node_7 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T3, M79217_PEA_1_T15 and M79217_PEA_1_T18. Table 5257 below describes the starting and ending position of this segment on each transcript. Table 5257 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1, M79217_PEA_1_P8 and M79217_PEA_1_P11.

Segment cluster M79217_PEA_l_node_12 according to the present invention can be found in the following transcript(s): M79217JPEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T15. Table 5258 below describes the starting and ending position of this segment on each transcript.

Table 5258 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1 and M79217 PEA 1 P8.

Segment cluster M79217_PEA_l_node_26 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217_PEA_1_T3. Table 5259 below describes the starting and ending position of this segment on each transcript.

Table 5259 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_27 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217_PEA_1_T3. Table 5260 below describes the starting and ending position of this segment on each transcript.

Table 5260 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1. Segment cluster M79217_PEA_l_node_30 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217_PEA_1_T3. Table 5261 below describes the starting and ending position of this segment on each transcript.

Table 5261 - Segment location on transcripts

This segment can be found in the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_32 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217_PEA_1_T3. Table 5262 below describes the starting and ending position of this segment on each transcript.

Table 5262 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_36 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217JPEA_1_T3. Table 5263 below describes the starting and ending position of this segment on each transcript. Table 5263 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_39 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217JPEA_1_T3. Table 5264 below describes the starting and ending position of this segment on each transcript.

Table 5264 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1.

Segment cluster M79217_PEA_l_node_40 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1 and M79217JPEA_1_T3. Table 5265 below describes the starting and ending position of this segment on each transcript.

Table 5265 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217JPEA_1_P1.

Segment cluster M79217_PEA_l_node_42 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217_PEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T18. Table 5266 below describes the starting and ending position of this segment on each transcript. Table 5266 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1. This segment can also be found in the following protein(s): M79217_PEA_1_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M79217_PEA_l_node_43 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M79217JPEA_1_T1, M79217_PEA_1_T3 and M79217_PEA_1_T18. Table 5267 below describes the starting and ending position of this segment on each transcript.

Table 5267 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M79217_PEA_1_P1. This segment can also be found in the following protein(s): M79217_PEA_1_P11, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER N23262

Cluster N23262 features 9 transcript(s) and 44 segment(s) of interest, the names for which are given in Tables 5268 and 5269, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5270.

Table 5268 - Transcripts of interest

Transcrip t Name

N23262 TO

N23262 Tl

N23262 T4

N23262 T5

N23262 T6

N23262 T16

N23262 T22

N23262 T23

N23262 T27

Table 5269 - Segments of interest

Segment Name

N23262 node 0

N23262 node 2

N23262 node 5

N23262 node 6

N23262 node 8 N23262 node 10

N23262 node 12

N23262 node 15

N23262 node 18

N23262 node 19

N23262 node 21

N23262 node 23

N23262 node 25

N23262 node 27

N23262_node 29

N23262 node 31

N23262 node 34

N23262 node 38

N23262 node 41

N23262 node 44

N23262 node 50

N23262 node 51

N23262 node 53

N23262 node 54

N23262 node 58

N23262 node 59

N23262 node 62

N23262 node 67

N23262 node 69

N23262 node 74

N23262_node 79

N23262 node 80

N23262 node 81

N23262 node 83

N23262 node 84

N23262 node 85

N23262 node 3

N23262 node 32

N23262 node 47

N23262 node 52

N23262 node 65

N23262 node 71

N23262 node 72

N23262 node 82

Table 5270 - Proteins of interest

As noted above, cluster N23262 features 44 segment(s), which were listed in Table 5269 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster N23262_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T4, N23262_T5 and N23262_T6. Table 5271 below describes the starting and ending position of this segment on each transcript.

Table 5271 - Segment location on transcripts

This segment can be found in the following protein(s): N23262JP1, N23262_P5 and N23262 P6.

Segment cluster N23262_node_2 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T1 and N23262_T27. Table 5272 below describes the starting and ending position of this segment on each transcript. Table 5272 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P2.

Segment cluster N23262_node_5 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6 and N23262_T27. Table 5273 below describes the starting and ending position of this segment on each transcript.

Table 5273 - Segment location on transcripts

This segment can be found in the following protein(s): N23262JP1, N23262_P2, N23262_P5 andN23262_P6.

Segment cluster N23262_node_6 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T27. Table 5274 below describes the starting and ending position of this segment on each transcript.

Table 5274 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster N23262_node_8 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5275 below describes the starting and ending position of this segment on each transcript.

Table 5275 - Segment location on transcripts

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262 P5 and N23262 P6.

Segment cluster N23262_node_10 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5276 below describes the starting and ending position of this segment on each transcript.

Table 5276 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5277.

Table 5277 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): N23262JP1, N23262_P2, N23262_P5 and N23262_P6.

Segment cluster N23262_node_12 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5278 below describes the starting and ending position of this segment on each transcript.

Table 5278 - Segment location on transcripts

This segment can be found in the following protein(s): N23262JP1, N23262_P2, N23262JP5 and N23262_P6.

Segment cluster N23262_node_15 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262JN, N23262_T4, N23262_T5 and N23262_T6. Table 5279 below describes the starting and ending position of this segment on each transcript.

Table 5279 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5280.

Table 5280 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): N23262JP1, N23262_P2, N23262 P5 and N23262 P6.

Segment cluster N23262_node_18 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5281 below describes the starting and ending position of this segment on each transcript.

Table 5281 - Segment location on transcripts

N23262 T6 980 1471

This segment can be found in the following protein(s): N23262JP1, N23262_P2, N23262_P5 and N23262JP6.

Segment cluster N23262_node_19 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262JTO, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5282 below describes the starting and ending position of this segment on each transcript. Table 5282 - Segment location on transcripts

This segment can be found in the following protein(s): N23262JP1, N23262_P2, N23262 P5 and N23262 P6.

Segment cluster N23262_node_21 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5283 below describes the starting and ending position of this segment on each transcript. Table 5283 - Segment location on transcripts

I N23262 T6 | I 1598 I ! 2050 I

This segment can be found in the following protein(s):N23262_Pl, N23262_P2, N23262_P5 and N23262_P6.

Segment cluster N23262_node_23 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5284 below describes the starting and ending position of this segment on each transcript. Table 5284 - Segment location on transcripts

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262 P5 and N23262 P6.

Segment cluster N23262_node_25 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5285 below describes the starting and ending position of this segment on each transcript. Table 5285 - Segment location on transcripts

N23262 T6 2179 2320

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262_P5 and N23262 J^>6.

Segment cluster N23262_node_27 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5286 below describes the starting and ending position of this segment on each transcript. Table 5286 - Segment location on transcripts

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262 P5 and N23262 P6.

Segment cluster N23262_node_29 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5287 below describes the starting and ending position of this segment on each transcript. Table 5287 - Segment location on transcripts

N23262 T6 2510 2671

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262_P5 and N23262_P6.

Segment cluster N23262_node_31 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5288 below describes the starting and ending position of this segment on each transcript.

Table 5288 - Segment location on transcripts

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262 P5 and N23262 P6.

Segment cluster N23262_node_34 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5289 below describes the starting and ending position of this segment on each transcript. Table 5289 - Segment location on transcripts

N23262 T6 2822 2949

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262_P5 and N23262_P6.

Segment cluster N23262_node_38 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5290 below describes the starting and ending position of this segment on each transcript. Table 5290 - Segment location on transcripts

This segment can be found in the following protein(s): N23262JP1, N23262_P2, N23262 P5 and N23262 P6.

Segment cluster N23262_node_41 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5291 below describes the starting and ending position of this segment on each transcript. Table 5291 - Segment location on transcripts

N23262 T6 3094 3280

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262_P5 and N23262_P6.

Segment cluster N23262_node_44 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5292 below describes the starting and ending position of this segment on each transcript.

Table 5292 - Segment location on transcripts

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262 P5 and N23262 P6.

Segment cluster N23262_node_50 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T16 and N23262_T23. Table 5293 below describes the starting and ending position of this segment on each transcript.

Table 5293 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P7. This segment can also be found in the following protein(s): N23262_P14, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_51 according to the present invention is supported by 17 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 andN23262_T23. Table 5294 below describes the starting and ending position of this segment on each transcript.

Table 5294 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P7. This segment can also be found in the following protein(s): N23262JP1, N23262_P2, N23262_P5, N23262_P6 and N23262_P14, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_53 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T23. Table 5295 below describes the starting and ending position of this segment on each transcript.

Table 5295 - Segment location on transcripts

This segment can be found in the following protein(s): N23262JP14.

Segment cluster N23262_node_54 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T23. Table 5296 below describes the starting and ending position of this segment on each transcript.

Table 5296 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N23262_P14.

Segment cluster N23262_node_58 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T4, N23262_T5, N23262_T6 and N23262JN 6. Table 5297 below describes the starting and ending position of this segment on each transcript.

Table 5297 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P7. This segment can also be found in the following protein(s): N23262_P5 and N23262_P6, since it is in the coding region for the corresponding transcript. Segment cluster N23262_node_59 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T4, N23262_T5, N23262_T6 and N23262_T16. Table 5298 below describes the starting and ending position of this segment on each transcript.

Table 5298 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5 and N23262_P6. This segment can also be found in the following protein(s): N23262_P7, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_62 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5,

N23262_T6 and N23262_T16. Table 5299 below describes the starting and ending position of this segment on each transcript.

Table 5299 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5 and N23262_P6. This segment can also be found in the following protein(s): N23262_P1, N23262_P2 and N23262_P7, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_67 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T5. Table 5300 below describes the starting and ending position of this segment on each transcript.

Table 5300 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N23262_P5.

Segment cluster N23262_node_69 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T22. Table 5301 below describes the starting and ending position of this segment on each transcript. Table 5301 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N23262_P12.

Segment cluster N23262_node_74 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s) : N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 and N23262_T22. Table 5302 below describes the starting and ending position of this segment on each transcript.

Table 5302 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262JP5 and N23262_P6. This segment can also be found in the following protein(s): N23262JP1, N23262_P2, N23262_P7 and N23262_P12, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_79 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262JN, N23262_T4, N23262_T5, N23262_T6, N23262_T16 and N23262_T22. Table 5303 below describes the starting and ending position of this segment on each transcript.

Table 5303 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5 and N23262_P6. This segment can also be found in the following protein(s): N23262JP1, N23262_P2, N23262_P7 and N23262_P12, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_80 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 and N23262_T22. Table 37 below describes the starting and ending position of this segment on each transcript.

Table 5304 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262JP5 and N23262JP6. This segment can also be found in the following protein(s): N23262JP1, N23262_P2, N23262_P7 and N23262_P12, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_81 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 and N23262_T22. Table 5305 below describes the starting and ending position of this segment on each transcript.

Table 5305 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5 and N23262_P6. This segment can also be found in the following protein(s): N23262_P1, N23262_P2, N23262_P7 and N23262_P12, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_83 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 and N23262_T22. Table 5306 below describes the starting and ending position of this segment on each transcript.

Table 5306 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5 and N23262_P6. This segment can also be found in the following protem(s): N23262_P1, N23262JP2, N23262_P7 and N23262_P12, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_84 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262__T16 and N23262_T22. Table 5307 below describes the starting and ending position of this segment on each transcript.

Table 5307 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N23262JP1, N23262_P2, N23262JP5, N23262JP6, N23262_P7 and N23262 P12.

Segment cluster N23262_node_85 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 and N23262_T22. Table 5308 below describes the starting and ending position of this segment on each transcript.

Table 5308 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): N23262_P1, N23262_P2, N23262_P5, N23262_P6, N23262_P7 and N23262 P12.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster N23262_node_3 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262JTO, N23262_T1, N23262_T4, N23262_T5, N23262_T6 and N23262_T27. Table 5309 below describes the starting and ending position of this segment on each transcript.

Table 5309 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P2. This segment can also be found in the following protein(s): N23262JP1, N23262_P5 and N23262JP6, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_32 according to the present invention can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5 and N23262_T6. Table 5310 below describes the starting and ending position of this segment on each transcript.

Table 5310 - Segment location on transcripts

This segment can be found in the following protein(s): N23262JP1, N23262_P2,

N23262 P5 and N23262 P6.

Segment cluster N23262_node_47 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1 , N23262_T4, N23262_T5 and N23262_T6. Table 5311 below describes the starting and ending position of this segment on each transcript.

Table 5311 - Segment location on transcripts

This segment can be found in the following protein(s): N23262_P1, N23262_P2, N23262 P5 and N23262 P6.

SegiΗent cluster N23262_node_52 according to the present invention can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T16 and N23262_T23. Table 5312 below describes the starting and ending position of this segment on each transcript.

Table 5312 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P7. This segment can also be found in the following protein(s): N23262JH, N23262_P2, N23262_P5 and N23262_P14, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_65 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6 and N23262_T16. Table 5313 below describes the starting and ending position of this segment on each transcript.

Table 5313 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5 and N23262_P6. This segment can also be found in the following protein(s): N23262_P1 , N23262_P2 and N23262_P7, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_71 according to the present invention can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 and N23262_T22. Table 5314 below describes the starting and ending position of this segment on each transcript.

Table 5314 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5, N23262_P6 andN23262_P12. This segment can also be found in the following protein(s): N23262_P1, N23262_P2 and N23262JP7, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_72 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 and N23262_T22. Table 5315 below describes the starting and ending position of this segment on each transcrip t.

Table 5315 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5, N23262_P6 and N23262JP12. This segment can also be found in the following protein(s): N23262JP1, N23262JP2 and N23262_P7, since it is in the coding region for the corresponding transcript.

Segment cluster N23262_node_82 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): N23262_T0, N23262_T1, N23262_T4, N23262_T5, N23262_T6, N23262_T16 andN23262_T22. Table 5316 below describes the starting and ending position of this segment on each transcript.

Table 5316 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): N23262_P5 and N23262_P6. This segment can also be found in the following protein(s): N23262_P1, N23262_P2, N23262_P7 and N23262_P12, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER R34187

Cluster R34187 features 2 transcript(s) and 7 segment(s) of interest, the names for which are given in Tables 5317 and 5318, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5319.

Table 5317 - Transcripts of interest

Transcript Name

R34187 T9

R34187 TlO

Table 5318 - Segments of interest

Segment Name

R34187 node 0

R34187 node 6

R34187 node 14

R34187 node 4

R34187 node 8

R34187 node 10

R34187 node 12

Table 5319 - Proteins of interest

R34187 P5 R34187 TlO

Cluster R.34187 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 128 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 128 and Table 5320. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues and hepatocellular carcinoma.

Table 5320 - Normal tissue distribution

Table 5321 - P values and ratios for expression in cancerous tissue

As noted above, cluster R34187 features 7 segment(s), which were listed in Table 5318 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R34187_node_0 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34187_T9 and R34187_T10. Table 5322 below describes the starting and ending position of this segment on each transcript.

Table 5322 - Segment location on transcripts

This segment can be found in the following protein(s): R34187JM and R34187_P5.

Segment cluster R34187_node_6 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34187_T10. Table 5323 below describes the starting and ending position of this segment on each transcript.

Table 5323 - Segment location on transcripts

This segment can be found in the following protein(s): R34187_P5.

Segment cluster R34187_node_14 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34187_T9. Table 5324 below describes the starting and ending position of this segment on each transcript.

Table 5324 ~ Segment location on transcripts

This segment can be found in the following protein(s): R34187_P4.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R34187_node_4 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34187_T9 and R34187_T10. Table 5325 below describes the starting and ending position of this segment on each transcript.

Table 5325 - Segment location on transcripts

This segment can be found in the following protein(s): R34187_P4 and R34187_P5.

Segment cluster R34187_node_8 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34187_T9. Table 5326 below describes the starting and ending position of this segment on each transcript.

Table 5326 - Segment location on transcripts

This segment can be found in the following protein(s): R34187_P4.

Segment cluster R34187_node_10 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34187_T9. Table 5327 below describes the starting and ending position of this segment on each transcript.

Table 5327 - Segment location on transcripts

This segment can be found in the following protein(s): R34187_P4.

Segment cluster R34187_node_12 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R34187_T9. Table 5328 below describes the starting and ending position of this segment on each transcript.

Table 5328 - Segment location on transcripts

This segment can be found in the following protein(s): R34187_P4.

DESCRIPTION FOR CLUSTER S56200

Cluster S56200 features 1 transcript(s) and 23 segment(s) of interest, the names for which are given in Tables 5329 and 5330, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5331.

Table 5329 - Transcripts of interest

Transcript Name

S56200 PEA 1 T8

Table 5330 - Segments of interest

Segment Name

S56200 PEA 1 node 1

S56200 PEA 1 node 2

S56200 PEA 1 node 7

S56200 PEA 1 node 11

S56200 PEA 1 node 13

S56200 PEA 1 node 15

S56200 PEA 1 node 17

S56200 PEA 1 node 29

S56200 PEA 1 node 30

S56200 PEA 1 node 35

S56200 PEA 1 node 39

S56200 PEA 1 node 40

S56200 PEA 1 node 43

S56200 PEA 1 node 0

S56200 PEA 1 node 4 S56200 PEA 1 node 21

S56200 PEA 1 node 22

S56200 PEA 1 node 28

S56200 PEA 1 node 31

S56200 PEA 1 node 32

S56200 PEA 1 node 36

S56200 PEA 1 node 38

S56200 PEA 1 node 41

Table 5331 - Proteins of interest

These sequences are variants of the known protein Myeloperoxidase precursor (SwissProt accession identifier PERMJHUMAN; known also according to the synonyms EC 1.11.1.7; MPO), referred to herein as the previously known protein.

Protein Myeloperoxidase precursor is known or believed to have the following function(s): Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. The sequence for protein Myeloperoxidase precursor is given at the end of the application, as "Myeloperoxidase precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5332. Table 5332 - Amino acid mutations for Known Protein

Protein Myeloperoxidase precursor localization is believed to be Lysosomal.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: anti-apoptosis; defense response; oxidative stress response, which are annotation(s) related to Biological Process; chromatin binding; peroxidase; calcium binding; oxidoreductase, which are annotation(s) related to Molecular Function; and nucleus; lysosome, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.clT/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 5333.

Table 5333 - Oligonucleotides related to this cluster

As noted above, cluster S56200 features 23 segment(s), which were listed in Table 5330 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster S56200_PEA_l_node_l according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5334 below describes the starting and ending position of this segment on each transcript.

Table 5334 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_2 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_J_T8. Table 5335 below describes the starting and ending position of this segment on each transcript.

Table 5335 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_7 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5336 below describes the starting and ending position of this segment on each transcript.

Table 5336 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7. Segment cluster S56200_PEA_l_node_l 1 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200JPEA_l_T8. Table 5337 below describes the starting and ending position of this segment on each transcript.

Table 5337 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_13 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5338 below describes the starting and ending position of this segment on each transcript.

Table 5338 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_15 according to the present invention is supported by 44 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5339 below describes the starting and ending position of this segment on each transcript.

Table 5339 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7. Segment cluster S56200_PEA_l_node_17 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200JPEA_l_T8. Table 5340 below describes the starting and ending position of this segment on each transcript.

Table 5340 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_29 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5341 below describes the starting and ending position of this segment on each transcript.

Table 5341 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_30 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5342 below describes the starting and ending position of this segment on each transcript.

Table 5342 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7. Segment cluster S56200JPEA_l_node_35 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5343 below describes the starting and ending position of this segment on each transcript.

Table 5343 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_39 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5344 below describes the starting and ending position of this segment on each transcript.

Table 5344 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200JPEA_l_node_40 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5345 below describes the starting and ending position of this segment on each transcript.

Table 5345 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_43 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5346 below describes the starting and ending position of this segment on each transcript.

Table 5346 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S56200JPEA__l_P7.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster S56200_PEA_l_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5347 below describes the starting and ending position of this segment on each transcript.

Table 5347 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l_P7. Segment cluster S56200_PEA_l_node_4 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5348 below describes the starting and ending position of this segment on each transcript.

Table 5348 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_21 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5349 below describes the starting and ending position of this segment on each transcript.

Table 5349 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200JPEA_l_node_22 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5350 below describes the starting and ending position of this segment on each transcript.

Table 5350 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_JPEA_l_P7. Segment cluster S56200_PEA_l_node_28 according to the present invention is supported by 34 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200JPEA_l_T8. Table 5351 below describes the starting and ending position of this segment on each transcript.

Table 5351 - Segment location on transcripts

This segment can be found in the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_31 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5352 below describes the starting and ending position of this segment on each transcript.

Table 5352 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l JP7.

Segment cluster S56200JPEA_l_node_32 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200JPEA_1_T8. Table 5353 below describes the starting and ending position of this segment on each transcript.

Table 5353 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_36 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5354 below describes the starting and ending position of this segment on each transcript.

Table 5354 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200JPEA_l_node_38 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5355 below describes the starting and ending position of this segment on each transcript.

Table 5355 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l_P7.

Segment cluster S56200_PEA_l_node_41 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S56200_PEA_l_T8. Table 5356 below describes the starting and ending position of this segment on each transcript. Table 5356 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S56200_PEA_l_P7.

DESCRIPTION FOR CLUSTER S95936

Cluster S95936 features 1 transcript(s) and 64 segment(s) of interest, the names for which are given in Tables 5357 and 5358, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5359. Table 5357 - Transcripts of interest

Transcript Name

S95936 PEA 1 TlO

Table 5358 - Segments of interest

Segment Name

S95936_ _PEA_ _.1. _node_ 22

S95936 PEA 1 node 69

S95936 PEA 1 node 104

S95936 PEA 1 node 9

S95936 PEA 1 node 11

S95936 PEA 1 node 12

S95936 PEA 1 node 13

S95936 PEA 1 node 14

S95936 PEA 1 node 15

S95936 PEA 1 node 16

S95936 PEA 1 node 17

S95936 PEA 1 node 19 S95936 PEA 1 node 20

S95936 PEA 1 node 21

S95936 PEA 1 node 23

S95936 PEA 1 node 24

S95936 PEA 1 node 25

S95936 PEA 1 node 26

S95936 PEA 1 node 27

S95936 PEA 1 node 28

S95936 PEA 1 node 29

S95936 PEA 1 node 30

S95936 PEA 1 node 32

S95936 PEA 1 node 33

S95936 PEA 1 node 37

S95936 PEA 1 node 38

S95936 PEA 1 node 40

S95936 PEA 1 node 41

S95936 PEA 1 node 42

S95936 PEA 1 node 45

S95936 PEA 1 node 46

S95936 PEA 1 node 47

S95936 PEA 1 node 48

S95936 PEA 1 node 49

S95936 PEA 1 node 50

S95936 PEA 1 node 51

S95936 PEA 1 node 53

S95936 _PEA_ 1 node 54

S95936 PEA 1 node 55

S95936 PEA 1 node 65

S95936 PEA 1 node 67

S95936 PEA 1 node 70

S95936 PEA 1 node 71

S95936 PEA 1 node 74

S95936 PEA 1 node 75

S95936 PEA 1 node 76

S95936 PEA 1 node 79

S95936 PEA 1 node 80

S95936 PEA 1 node 81

S95936 PEA 1 node 86

S95936 PEA 1 node 87

S95936 PEA 1 node 88

S95936. PEA 1. node _89

S95936 PEA 1 node 90

S95936 PEA 1 node 91

S95936 PEA 1 node 92 S95936 PEA 1 node 93

S95936 PEA 1 node 94

S95936 PEA 1 node 97

S95936 PEA 1 node 98

S95936 PEA 1 node 99

S95936 PEA 1 node 100

S95936 PEA 1 node 102

S95936 PEA 1 node 103

Table 5359 - Proteins of interest

These sequences are variants of the known protein Serotransferrin precursor (SwissProt accession identifier TRFE HUMAN; known also according to the synonyms Transferrin; Siderophilin; Beta- 1 -metal binding globulin; PRO 1400), referred to herein as the previously known protein.

Protein Serotransferrin precursor is known or believed to have the following function(s): Transferrins are iron binding transport proteins which can bind two atoms of ferric iron in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. The sequence for protein Serotransferrin precursor is given at the end of the application, as "Serotransferrin precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5360.

Table 5360 - Amino acid mutations for Known Protein

Protein Serotransferrin precursor localization is believed to be Secreted.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: transport; iron transport; iron homeostasis, which are annotation(s) related to Biological Process; ferric iron binding, which are annotation(s) related to Molecular Function; and extracellular space, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nrm.nih.gov/projects/LocusLink/>.

Cluster S95936 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 129 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 129 and Table 5361. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: pancreas carcinoma.

Table 5361 - Normal tissue distribution

Table 5362 - P values and ratios for expression in cancerous tissue

As noted above, cluster S95936 features 64 segment(s), which were listed in Table 5358 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster S95936_PEA_l_node_22 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936JPEA_l_T10. Table 5363 below describes the starting and ending position of this segment on each transcript.

Table 5363 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_69 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5364 below describes the starting and ending position of this segment on each transcript. Table 5364 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936JPEA_l_node_104 according to the present invention is supported by 95 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5365 below describes the starting and ending position of this segment on each transcript.

Table 5365 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S95936JPEA_1_P4.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster S95936_PEA_l_node_9 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5366 below describes the starting and ending position of this segment on each transcript.

Table 5366 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_ll according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5367 below describes the starting and ending position of this segment on each transcript.

Table 5367 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1JP4. Segment cluster S95936_PEA_1 jnode_12 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5368 below describes the starting and ending position of this segment on each transcript.

Table 5368 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_13 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5369 below describes the starting and ending position of this segment on each transcript.

Table 5369 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_14 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5370 below describes the starting and ending position of this segment on each transcript.

Table 5370 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S95936 PEA 1 P4.

Segment cluster S95936_PEA_l_node_15 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5371 below describes the starting and ending position of this segment on each transcript.

Table 5371 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936JPEA_1 jnode_16 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5372 below describes the starting and ending position of this segment on each transcript. Table 5372 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_17 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5373 below describes the starting and ending position of this segment on each transcript.

Table 5373 - Segment location on transcripts

I S95936 PEA 1 TlO I 203 I I 249 I

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1JP4.

Segment cluster S95936JPEA_l_node_19 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5374 below describes the starting and ending position of this segment on each transcript.

Table 5374 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_20 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5375 below describes the starting and ending position of this segment on each transcript.

Table 5375 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_21 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5376 below describes the starting and ending position of this segment on each transcript. Table 5376 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S95936_PEAJ_P4.

Segment cluster S95936_PEA_l_node_23 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5377 below describes the starting and ending position of this segment on each transcript.

Table 5377 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_24 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5378 below describes the starting and ending position of this segment on each transcript.

Table 5378 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1 JP4.

Segment cluster S95936_PEA_l_node_25 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5379 below describes the starting and ending position of this segment on each transcript.

Table 5379 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_1 jnode_26 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5380 below describes the starting and ending position of this segment on each transcript. Table 5380 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_1 jnode_27 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5381 below describes the starting and ending position of this segment on each transcript.

Table 5381 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_28 according to the present invention can be found in the following transcript(s): S95936JPEA_l_T10. Table 5382 below describes the starting and ending position of this segment on each transcript. Table 5382 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1JP4.

Segment cluster S95936_PEA_l_node_29 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5383 below describes the starting and ending position of this segment on each transcript.

Table 5383 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_30 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5384 below describes the starting and ending position of this segment on each transcript.

Table 5384 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_32 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5385 below describes the starting and ending position of this segment on each transcript. Table 5385 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_33 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5386 below describes the starting and ending position of this segment on each transcript.

Table 5386 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_37 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5387 below describes the starting and ending position of this segment on each transcript.

Table 5387 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_38 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5388 below describes the starting and ending position of this segment on each transcript. Table 5388 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_40 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5389 below describes the starting and ending position of this segment on each transcript.

Table 5389 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936JPEA_l_node_41 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): 895936JPEA_l_T10. Table 5390 below describes the starting and ending position of this segment on each transcript.

Table 5390 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_42 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5391 below describes the starting and ending position of this segment on each transcript. Table 5391 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_45 according to the present invention is supported by 95 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5392 below describes the starting and ending position of this segment on each transcript.

Table 5392 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_46 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5393 below describes the starting and ending position of this segment on each transcript.

Table 5393 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_47 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5394 below describes the starting and ending position of this segment on each transcript.

Table 5394 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_48 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5395 below describes the starting and ending position of this segment on each transcript.

Table 5395 - Segment location on transcripts

This segment can be found in the following protein(s): S95936JPEA_1_P4.

Segment cluster S95936_PEA_l_node_49 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5396 below describes the starting and ending position of this segment on each transcript. Table 5396 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1JP4.

Segment cluster S95936_PEA_l_node_50 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5397 below describes the starting and ending position of this segment on each transcript.

Table 5397 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_51 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5398 below describes the starting and ending position of this segment on each transcript.

Table 5398 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_53 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5399 below describes the starting and ending position of this segment on each transcript.

Table 5399 - Segment location on transcripts

This segment can be found in the following ρrotein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_54 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5400 below describes the starting and ending position of this segment on each transcript.

Table 5400 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_55 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5401 below describes the starting and ending position of this segment on each transcript.

Table 5401 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_65 according to the present invention is supported by 137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5402 below describes the starting and ending position of this segment on each transcript.

Table 5402 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_67 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936JPEA_l_T10. Table 5403 below describes the starting and ending position of this segment on each transcript.

Table 5403 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_70 according to the present invention can be found in the following transcript(s): S95936JPEA_l_T10. Table 5404 below describes the starting and ending position of this segment on each transcript.

Table 5404 - Segment location on transcripts

This segment can be found in the following protein(s): S95936JPEA_1JP4.

Segment cluster S95936_PEA_l_node_71 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5405 below describes the starting and ending position of this segment on each transcript.

Table 5405 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_74 according to the present invention is supported by 118 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5406 below describes the starting and ending position of this segment on each transcript.

Table 5406 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4. Segment cluster S95936_PEA_l_node_75 according to the present invention is supported by 117 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5407 below describes the starting and ending position of this segment on each transcript.

Table 5407 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_76 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5408 below describes the starting and ending position of this segment on each transcript.

Table 5408 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_79 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5409 below describes the starting and ending position of this segment on each transcript. Table 5409 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4. Segment cluster S95936_PEA_l_node_80 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5410 below describes the starting and ending position of this segment on each transcript.

Table 5410 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_ l_node_81 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5411 below describes the starting and ending position of this segment on each transcript.

Table 5411 - Segment location on transcripts

This segment can be found in the following protein(s): S95936JPEA 1JP4.

Segment cluster S95936_PEA_l_node_86 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5412 below describes the starting and ending position of this segment on each transcript.

Table 5412 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_87 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936JPEA_l_T10. Table 5413 below describes the starting and ending position of this segment on each transcript.

Table 5413 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_88 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5414 below describes the starting and ending position of this segment on each transcript.

Table 5414 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_89 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5415 below describes the starting and ending position of this segment on each transcript.

Table 5415 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_90 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5416 below describes the starting and ending position of this segment on each transcript. Table 5416 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_91 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5417 below describes the starting and ending position of this segment on each transcript.

Table 5417 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_92 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5418 below describes the starting and ending position of this segment on each transcript. Table 5418 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_93 according to the present invention is supported by 136 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5419 below describes the starting and ending position of this segment on each transcript.

Table 5419 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_1 jnode_94 according to the present invention can be found in the following transcript(s): S95936_PEA_l_T10. Table 5420 below describes the starting and ending position of this segment on each transcript.

Table 5420 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_97 according to the present invention is supported by 139 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5421 below describes the starting and ending position of this segment on each transcript.

Table 5421 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_98 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): 895936_PEA_l_T10. Table 5422 below describes the starting and ending position of this segment on each transcript.

Table 5422 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936JPEA_l__node_99 according to the present invention is supported by 132 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): S95936JPEA_l_T10. Table 5423 below describes the starting and ending position of this segment on each transcript.

Table 5423 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

Segment cluster S95936_PEA_l_node_100 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5424 below describes the starting and ending position of this segment on each transcript.

Table 5424 - Segment location on transcripts

This segment can be found in the following protein(s): S95936JPEA_1_P4.

Segment cluster S95936_PEA_l_node_102 according to the present invention is supported by 106 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5425 below describes the starting and ending position of this segment on each transcript.

Table 5425 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1JP4.

Segment cluster S95936_PEA_l_node_103 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): S95936_PEA_l_T10. Table 5426 below describes the starting and ending position of this segment on each transcript.

Table 5426 - Segment location on transcripts

This segment can be found in the following protein(s): S95936_PEA_1_P4.

DESCRIPTION FOR CLUSTER T07560

Cluster T07560 features 8 transcript(s) and 69 segment(s) of interest, the names for which are given in Tables 5427 and 5428, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5429.

Table 5427 - Transcripts of interest

Transcript Name

T07560 TlO

T07560 T18

T07560 T19

T07560 T20

T07560 T24

Table5428-Segmentsofinterest

T07560 node 76

T07560 node 77

T07560 node 78

T07560 node 79

T07560 node 82

T07560 node 83

T07560 node 84

T07560 node 85

T07560 node 86

T07560_node _88

T07560 node 89

T07560 node 90

T07560 node 91

T07560 node 92

T07560 node 93

T07560 node 95

T07560 node 98

T07560 node 99

T07560 node 100

T07560 node 101

T07560 node 102

T07560 node 103

T07560 node 104

T07560 node 105

T07560 node 106

T07560_node _107

T07560 node 108

T07560 node 109

T07560 node 110

T07560 node 111

T07560 node 112

T07560 node 113

Table 5429 - Proteins of interest

Cluster T07560 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 130 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 130 and Table 5430. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, a mixture of malignant tumors from different tissues, hepatocellular carcinoma, breast malignant tumors, myosarcoma and pancreas carcinoma.

Table 5430 - Normal tissue distribution

Uterus 95

Table 5431 - P values and ratios for expression in cancerous tissue

As noted above, cluster T07560 features 69 segment(s), which were listed in Table 5428 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster T07560_node_19 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T53. Table 5432 below describes the starting and ending position of this segment on each transcript.

Table 5432 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P25.

Segment cluster T07560_node_23 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T53. Table 5433 below describes the starting and ending position of this segment on each transcript.

Table 5433 - Segment location on transcripts

This segment can be found in the following protein(s): T07560JP25.

Segment cluster T07560_node_24 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T53. Table 5434 below describes the starting and ending position of this segment on each transcript.

Table 5434 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P25. Segment cluster T07560_node_29 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10 and T07560_T59. Table 5435 below describes the starting and ending position of this segment on each transcript.

Table 5435 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34 and T07560_P31.

Segment cluster T07560_node_30 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10 and T07560_T59. Table 5436 below describes the starting and ending position of this segment on each transcript.

Table 5436 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34 and T07560JP31.

Segment cluster T07560_node_31 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10 and T07560_T59. Table 5437 below describes the starting and ending position of this segment on each transcript.

Table 5437 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34 and T07560JP31.

Segment cluster T07560_node_34 according to the present invention is supported by 6 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T07560_T18. Table 5438 below describes the starting and ending position of this segment on each transcript.

Table 5438 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560JP34.

Segment cluster T07560_node_37 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T20. Table 5439 below describes the starting and ending position of this segment on each transcript.

Table 5439 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34. Segment cluster T07560_node_39 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T19. Table 5440 below describes the starting and ending position of this segment on each transcript.

Table 5440 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_44 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T53 and T07560_T59. Table 5441 below describes the starting and ending position of this segment on each transcript. Table 5441 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34. This segment can also be found in the following protein(s): T07560_P25 and T07560_P31, since it is in the coding region for the corresponding transcript. Segment cluster T07560_node_45 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T53 and T07560_T59. Table 5442 below describes the starting and ending position of this segment on each transcript.

Table 5442 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P25 and T07560JP31.

Segment cluster T07560_node_66 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T24 and T07560_T25. Table 5443 below describes the starting and ending position of this segment on each transcript.

Table 5443 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_67 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T24. Table 5444 below describes the starting and ending position of this segment on each transcript.

Table 5444 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_80 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5445 below describes the starting and ending position of this segment on each transcript. Table 5445 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_81 according to the present invention is supported by 141 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5446 below describes the starting and ending position of this segment on each transcript. Table 5446 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P34.

Segment cluster T07560_node_87 according to the present invention is supported by 148 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5447 below describes the starting and ending position of this segment on each transcript.

Table 5447 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P34.

Segment cluster T07560_node_96 according to the present invention is supported by 179 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560JN9, T07560_T20, T07560_T24 and T07560_T25. Table 5448 below describes the starting and ending position of this segment on each transcript.

Table 5448 - Segment location on transcripts

T07560 T25 3377 3545

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_97 according to the present invention is supported by 171 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5449 below describes the starting and ending position of this segment on each transcript. Table 5449 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T07560_node_0 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T53. Table 5450 below describes the starting and ending position of this segment on each transcript.

Table 5450 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P25.

Segment cluster T07560jnode_6 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T53. Table 5451 below describes the starting and ending position of this segment on each transcript.

Table 5451 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P25.

Segment cluster T07560_node_18 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T53. Table 5452 below describes the starting and ending position of this segment on each transcript.

Table 5452 - Segment location on transcripts

This segment can be found in the following protein(s): T07560JP25.

Segment cluster T07560_node_21 according to the present invention can be found in the following transcript(s): T07560_T53. Table 5453 below describes the starting and ending position of this segment on each transcript.

Table 5453 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P25.

Segment cluster T07560_node_22 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T53. Table 5454 below describes the starting and ending position of this segment on each transcript.

Table 5454 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P25.

Segment cluster T07560_node_47 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5455 below describes the starting and ending position of this segment on each transcript.

Table 5455 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_48 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5456 below describes the starting and ending position of this segment on each transcript.

Table 5456 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_50 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5457 below describes the starting and ending position of this segment on each transcript.

Table 5457 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_51 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5458 below describes the starting and ending position of this segment on each transcript.

Table 5458 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_53 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5459 below describes the starting and ending position of this segment on each transcript.

Table 5459 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_54 according to the present invention is supported by 97 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5460 below describes the starting and ending position of this segment on each transcript.

Table 5460 - Segment location on transcripts

T07560 T20 667 758

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560JP34.

Segment cluster T07560_node_57 according to the present invention is supported by 102 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5461 below describes the starting and ending position of this segment on each transcript.

Table 5461 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_58 according to the present invention is supported by 87 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5462 below describes the starting and ending position of this segment on each transcript.

Table 5462 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560JP34. Segment cluster T07560_node_60 according to the present invention is supported by 108 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5463 below describes the starting and ending position of this segment on each transcript.

Table 5463 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_63 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19 and T07560_T20. Table 5464 below describes the starting and ending position of this segment on each transcript.

Table 5464 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560JP34.

Segment cluster T07560_node_68 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5465 below describes the starting and ending position of this segment on each transcript.

Table 5465 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_73 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5466 below describes the starting and ending position of this segment on each transcript.

Table 5466 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_74 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5467 below describes the starting and ending position of this segment on each transcript.

Table 5467 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560JP34.

Segment cluster T07560_node_75 according to the present invention is supported by 95 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5468 below describes the starting and ending position of this segment on each transcript.

Table 5468 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_76 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5469 below describes the starting and ending position of this segment on each transcript.

Table 5469 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_77 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5470 below describes the starting and ending position of this segment on each transcript.

Table 5470 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_78 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5471 below describes the starting and ending position of this segment on each transcript.

Table 5471 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_79 according to the present invention is supported by 76 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5472 below describes the starting and ending position of this segment on each transcript.

Table 5472 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_82 according to the present invention is supported by 128 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5473 below describes the starting and ending position of this segment on each transcript.

Table 5473 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P34.

Segment cluster T07560_node_83 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5474 below describes the starting and ending position of this segment on each transcript.

Table 5474 - Segment location on transcripts

This segment can be found in the following protein(s): T07560JP34.

Segment cluster T07560_node_84 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5475 below describes the starting and ending position of this segment on each transcript.

Table 5475 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P34.

Segment cluster T07560_node_85 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5476 below describes the starting and ending position of this segment on each transcript.

Table 5476 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P34.

Segment cluster T07560_node_86 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5477 below describes the starting and ending position of this segment on each transcript.

Table 5477 - Segment location on transcripts

This segment can be found in the following protein(s): T07560__P34.

Segment cluster T07560_node_88 according to the present invention is supported by 143 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5478 below describes the starting and ending position of this segment on each transcript.

Table 5478 - Segment location on transcripts

This segment can be found in the following protein(s): T07560JP34.

Segment cluster T07560_node_89 according to the present invention is supported by 145 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560JN8, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5479 below describes the starting and ending position of this segment on each transcript.

Table 5479 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P34.

Segment cluster T07560_node_90 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5480 below describes the starting and ending position of this segment on each transcript.

Table 5480 - Segment location on transcripts

This segment can be found in the following protein(s): T07560_P34.

Segment cluster T07560_node_91 according to the present invention is supported by 180 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5481 below describes the starting and ending position of this segment on each transcript. Table 5481 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_92 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5482 below describes the starting and ending position of this segment on each transcript.

Table 5482 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_93 according to the present invention is supported by 162 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5483 below describes the starting and ending position of this segment on each transcript.

Table 5483 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_95 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5484 below describes the starting and ending position of this segment on each transcript.

Table 5484 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_98 according to the present invention is supported by 194 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5485 below describes the starting and ending position of this segment on each transcript.

Table 5485 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_99 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560 T25. Table 5486 below describes the starting and ending position of this segment on each transcript.

Table 5486 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_100 according to the present invention is supported by 223 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5487 below describes the starting and ending position of this segment on each transcript.

Table 5487 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_101 according to the present invention is supported by 246 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5488 below describes the starting and ending position of this segment on each transcript.

Table 5488 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_102 according to the present invention is supported by 219 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5489 below describes the starting and ending position of this segment on each transcript.

Table 5489 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_103 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560 T25. Table 5490 below describes the starting and ending position of this segment on each transcript.

Table 5490 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_104 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5491 below describes the starting and ending position of this segment on each transcript.

Table 5491 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_105 according to the present invention is supported by 201 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5492 below describes the starting and ending position of this segment on each transcript.

Table 5492 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_106 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5493 below describes the starting and ending position of this segment on each transcript.

Table 5493 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_107 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5494 below describes the starting and ending position of this segment on each transcript.

Table 5494 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_108 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5495 below describes the starting and ending position of this segment on each transcript.

Table 5495 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_109 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5496 below describes the starting and ending position of this segment on each transcript.

Table 5496 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_l 10 according to the present invention is supported by 189 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5497 below describes the starting and ending position of this segment on each transcript.

Table 5497 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_l 11 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5498 below describes the starting and ending position of this segment on each transcript.

Table 5498 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_l 12 according to the present invention can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5499 below describes the starting and ending position of this segment on each transcript.

Table 5499 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34.

Segment cluster T07560_node_l 13 according to the present invention is supported by 183 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T07560_T10, T07560_T18, T07560_T19, T07560_T20, T07560_T24 and T07560_T25. Table 5500 below describes the starting and ending position of this segment on each transcript.

Table 5500 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T07560_P34. DESCRIPTION FOR CLUSTER Tl 1628

Cluster Tl 1628 features 5 transcript(s) and 23 segment(s) of interest, the names for which are given in Tables 5501 and 5502, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5503.

Table 5501 - Transcripts of interest

Transcript Name

Tl 1628 PEA 1 T3

Tl 1628 PEA 1 T4

Tl 1628 PEA 1 T5

Tl 1628 PEA 1 T7

Tl 1628 PEA 1 T9

Table 5502 - Segments of interest

Segment Name

Tl 1628 PEA 1 node 1

Tl 1628 PEA 1 node 11

Tl 1628 PEA 1 node 22

Tl 1628 PEA 1 node 25

Tl 1628 PEA 1 node 31

Tl 1628 PEA 1 node 37

Tl 1628 PEA 1 node 0

Tl 1628 PEA 1 node 4

Tl 1628 PEA 1 node 9

Tl 1628 PEA 1 node 13

Tl 1628 PEA 1 node 14

Tl 1628 PEA 1 node 18

Tl 1628 PEA 1 node 19

Tl 1628 PEA 1 node 24

Tl 1628 _PEA_ 1 node _27

Tl 1628 PEA 1 node 28

Tl 1628 PEA 1 node 29

Tl 1628 PEA 1 node 30

Tl 1628 PEA 1 node 32

Tl 1628 PEA 1 node 33

Tl 1628 PEA 1 node 34

Tl 1628 PEA 1 node 35 Tl1628 PEA 1 node 36

Table 5503 - Proteins of interest

These sequences are variants of the known protein Myoglobin (SwissProt accession identifier MYG_HUMAN), referred to herein as the previously known protein.

Protein Myoglobin is known or believed to have the following function(s): Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. The sequence for protein Myoglobin is given at the end of the application, as "Myoglobin amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5504.

Table 5504 - Amino acid mutations for Known Protein

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster Tl 1628. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 131 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 131, concerning the number of heart- specific clones in libraries/sequences; as well as with regard to the histogram in Figure 132, concerning the actual expression of oligonucleotides in various tissues, including heart.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 27.1; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 1.2; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be l.20E-235.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 27.1, which clearly supports specific expression in heart tissue.

As noted above, cluster Tl 1628 features 23 segment(s), which were listed in Table 5502 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster Tl 1628_PEA_l_node_7 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628_PEA_1_T3. Table 5505 below describes the starting and ending position of this segment on each transcript.

Table 5505 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Tl 1628_PEA_1_P2.

Segment cluster T11628_PEA_l_node_ll according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Tl 1628_PEA_1_T5. Table 5506 below describes the starting and ending position of this segment on each transcript.

Table 5506 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Tl 1628_PEA_1_P2.

Segment cluster T11628JPEA_l_node_22 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628_PEA_1_T9. Table 5507 below describes the starting and ending position of this segment on each transcript.

Table 5507 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Tl 1628_PEA_1_P5.

Segment cluster Tl 1628_PEA_l_node_25 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Tl 1628_PEA_1_T3, Tl 1628JPEA_1_T4, Tl 1628_PEA_1_T5, Tl 1628_PEA_1_T7 and Tl 1628_PEA_1_T9. Table 5508 below describes the starting and ending position of this segment on each transcript. Table 5508 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5509.

Table 5509 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): T11628_PEA_1__P2, Tl 1628_PEA_l_P10 and Tl 1628_PEA_1_P5.

Segment cluster T11628_PEA_l_node_31 according to the present invention is supported by 137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcripts): T11628JPEA_1_T3, T11628_PEA_1_T4, T11628_PEA_1_T5, Tl 1628_PEA_1_T7 and Tl 1628JPEA_1_T9. Table 5510 below describes the starting and ending position of this segment on each transcript.

Table 5510 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11628JPEA_1_P2, T11628_PEA_l_P10 and T11628_PEA_1_P5.

Segment cluster Tl 1628_PEA_l_node_37 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Tl 1628_PEA_1_T3, Tl 1628JPEA_1_T4, T11628_PEA_1_T5, T11628_PEA_1_T7 and T11628_PEA_1_T9. Table 5511 below describes the starting and ending position of this segment on each transcript.

Table 5511 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T11628_PEA_1_P2, T11628_PEA_l_P10 and T11628_PEA_l_P5. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Tl 1628_PEA_l_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Tl 1628_PEA_1_T4. Table 5512 below describes the starting and ending position of this segment on each transcript.

Table 5512 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T11628_PEA_l_P10.

Segment cluster Tl 1628_PEA_l_node_4 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Tl 1628JPEA_1_T4. Table 5513 below describes the starting and ending position of this segment on each transcript.

Table 5513 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T11628_PEA_l_P10.

Segment cluster Tl 1628JPEA_l_node_9 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Tl 1628_PEA_1_T5 and Tl 1628_PEA_1_T7. Table 5514 below describes the starting and ending position of this segment on each transcript. Table 5514 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11628JPEA_1__P2.

Segment cluster Tl 1628_PEA_l_node_13 according to the present invention can be found in the following transcript(s): Tl 1628JPEA_1_T7. Table 5515 below describes the starting and ending position of this segment on each transcript.

Table 5515 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11628_PEA_1_P2.

Segment cluster Tl 1628_PEA_l_node_14 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628_PEA_1_T7. Table 5516 below describes the starting and ending position of this segment on each transcript.

Table 5516 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Tl 1628_PEA_1_P2. Segment cluster Tl 1628_PEA_l_node_18 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Tl 1628_PEA_1_T3, Tl 1628_PEA_1_T4, Tl 1628_PEA_1_T5 and Tl 1628_PEA_1_T7. Table 5517 below describes the starting and ending position of this segment on each transcript.

Table 5517 - Segment location on transcripts

This segment can be found in the following protein(s): T11628_PEA_1_P2 and T11628_PEA_l_P10.

Segment cluster Tl 1628_PEA_l_node_19 according to the present invention can be found in the following transcript(s): T11628_PEA_1_T3, T11628JPEA_1_T4, Tl 1628_PEA_1_T5 and Tl 1628_PEA_1_T7. Table 5518 below describes the starting and ending position of this segment on each transcript.

Table 5518 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1628_PEA_1_P2 and Tl 1628 PEA 1 PlO.

Segment cluster Tl 1628_PEA_l_node_24 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628_PEA_1_T3, T11628_PEA_1_T4, Tl 1628_PEA_1_T5, Tl 1628_PEA_1_T7 and Tl 1628_PEA_1_T9. Table 5519 below describes the starting and ending position of this segment on each transcript.

Table 5519 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1628_PEA_1_P2, T11628 PEA 1 P10 and T11628 PEA 1 P5.

Segment cluster Tl 1628_PEA_l_node_27 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628JPEA_1_T3, T11628_PEA_1_T4, T11628_PEA_1_T5, T11628_PEA_1_T7 and T11628JPEA_1_T9. Table 5520 below describes the starting and ending position of this segment on each transcript.

Table 5520 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5521.

Table 5521 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): Tl 1628JPEA_1_P2, Tl 1628_PEA_l_P10 and Tl 1628_PEA_1 JP5.

Segment cluster Tl 1628_PEA_l_node_28 according to the present invention is supported by 115 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628_PEA_1_T3, T11628_PEA_1_T4, T11628_PEA_1_T5, T11628_PEA_1_T7 and T11628_PEA_1_T9. Table 5522 below describes the starting and ending position of this segment on each transcript. Table 5522 - Segment location on transcripts

This segment can be found in the following protein(s): T11628_PEA_1_P2, Tl 1628 PEA 1 PlO and Tl 1628 PEA 1 P5.

Segment cluster Tl 1628_PEA_l_node_29 according to the present invention is supported by 113 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628_PEA_1_T3, T11628_PEA_1_T4, T11628_PEA_1_T5, T11628_PEA_1_T7 and T11628_PEA_1_T9. Table 5523 below describes the starting and ending position of this segment on each transcript. Table 5523 - Segment location on transcripts

This segment can be found in the following protein(s): Tl 1628_PEA_1_P2, Tl 1628_PEA_l_P10 and Tl 1628_PEA_1_P5.

Segment cluster Tl 1628_PEA_l_node_30 according to the present invention can be found in the following transcript(s): T11628_PEA_1_T3, T11628JPEA_1_T4, T11628_PEA_1_T5, T11628J^>EA_1_T7 and T11628_PEA_1_T9. Table 5524 below describes the starting and ending position of this segment on each transcript.

Table 5524 - Segment location on transcripts

This segment can be found in the following protein(s): T11628_PEA_1_P2, T11628 PEA 1 P10 and T11628 PEA 1 P5.

Segment cluster Tl 1628_PEA_l_node_32 according to the present invention can be found in the following transcript(s): T11628_PEA_1_T3, Tl 1628_PEA_1_T4,

T11628_PEA_1_T5, T11628_PEA_1_T7 and T11628_PEA_1_T9. Table 5525 below describes the starting and ending position of this segment on each transcript.

Table 5525 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11628_PEA_1_P2, T11628_PEA_l_P10 and T11628_PEA_1_P5.

Segment cluster Tl 1628_PEA_l_node_33 according to the present invention can be found in the following transcript(s): Tl 1628_PEA_1_T3, Tl 1628_PEA_1_T4, T11628_PEA_1_T5, T11628_PEA_1_T7 and T11628_PEA_1_T9. Table 5526 below describes the starting and ending position of this segment on each transcript.

Table 5526 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T11628_PEA_1_P2, T11628_PEA_l_P10 and T11628_PEA_1_P5.

Segment cluster Tl 1628_PEA_l_node_34 according to the present invention is supported by 122 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Tl 1628_PEA_1_T3, Tl 1628_PEA_1_T4,

T11628_PEA_1_T5, T11628_PEA_1_T7 and T11628_PEA_1_T9. Table 5527 below describes the starting and ending position of this segment on each transcript.

Table 5527 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T11628_PEA_1_P2, T11628_PEA_l_P10 and T11628_PEA_1JP5.

Segment cluster Tl 1628JPEA_l_node_35 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628_PEA_1_T3, T11628_PEA_1_T4, Tl 1628_PEA_1_T5, Tl 1628_PEA_1_T7 and Tl 1628JPEA_1_T9. Table 5528 below describes the starting and ending position of this segment on each transcript.

Table 5528 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T11628_PEA_1_P2, T11628_PEA_l_P10 and T11628_PEA_l_P5.

Segment cluster T11628_PEA_l_node_36 according to the present invention is supported by 122 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T11628_PEA_1_T3, T11628_PEA_1_T4, Tl 1628_PEA_1_T5, Tl 1628_PEA_1_T7 and Tl 1628_PEA_1_T9. Table 5529 below describes the starting and ending position of this segment on each transcript.

Table 5529 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Tl 1628_PEA_1_P2, Tl 1628_PEA_l_P10 and Tl 1628_PEA_1_P5.

DESCRIPTION FOR CLUSTER Tl 9724

Cluster T 19724 features 2 transcript(s) and 24 segment(s) of interest, the names for which are given in Tables 5530 and 5531, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5532.

Table 5530 - Transcripts of interest

TranscriptName

Tl9724 T38

Tl9724 T41

Table5531 -Segmentsofinterest

SegmentName

Tl9724 node 30

Tl9724 node 48

Tl9724 node 50

Tl9724 node 59

Tl9724 node 62

Tl9724 node 65

Tl9724 node 70

Tl9724 node 72

Tl9724 node 76

Tl9724 node 49

Tl9724 node 52

Tl9724 node 53

Tl9724 node 54

Tl9724 node 60

Tl9724 node 61

Tl9724 node 63

T19724 node 66 T 19724 node 67

Tl 9724 node 68

Tl 9724 node 69

Tl 9724 node 71

Tl 9724 node 73

Tl 9724 node 74

Tl 9724 node 75

Table 5532 - Proteins of interest

These sequences are variants of the known protein DNA replication licensing factor MCM4 (SwissProt accession identifier MCM4_HUMAN; known also according to the synonyms CDC21 homolog; P1-CDC21), referred to herein as the previously known protein.

Protein DNA replication licensing factor MCM4 is known or believed to have the following function(s): Involved in the control of DNA replication. The sequence for protein DNA replication licensing factor MCM4 is given at the end of the application, as "DNA replication licensing factor MCM4 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5533.

Table 5533 - Amino acid mutations for Known Protein

Protein DNA replication licensing factor MCM4 localization is believed to be Nuclear (By similarity).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: DNA replication; DNA replication initiation; transcription regulation, which are annotation(s) related to Biological Process; nucleotide binding; DNA binding; ATP binding; DNA dependent adenosinetriphosphatase, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster T 19724 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 133 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in

Figure 133 and Table 5534. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues, kidney malignant tumors, ovarian carcinoma, skin malignancies and uterine malignancies. Table 5534 - Normal tissue distribution

Table 5535 - P values and ratios for expression in cancerous tissue

As noted above, cluster Tl 9724 features 24 segment(s), which were listed in Table 5531 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T19724_node_30 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T41. Table 5536 below describes the starting and ending position of this segment on each transcript.

Table 5536 - Segment location on transcripts

This segment can be found in the following protein(s): T19724_P23.

Segment cluster T19724_node_48 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38. Table 5537 below describes the starting and ending position of this segment on each transcript.

Table 5537 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724JP21.

Segment cluster T19724_node_50 according to the present invention is supported by 137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38. Table 5538 below describes the starting and ending position of this segment on each transcript. Table 5538 - Segment location on transcripts

This segment can be found in the following protein(s): T19724JP21.

Segment cluster T19724_node_59 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38. Table 5539 below describes the starting and ending position of this segment on each transcript.

Table 5539 - Segment location on transcripts

This segment can be found in the following protein(s): T19724_P21.

Segment cluster T19724_node_62 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38. Table 5540 below describes the starting and ending position of this segment on each transcript.

Table 5540 ~ Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724_P21.

Segment cluster T19724_node_65 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38. Table 5541 below describes the starting and ending position of this segment on each transcript. Table 5541 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724JP21.

Segment cluster T19724_node_70 according to the present invention is supported by 45 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T19724_T38 and T19724_T41. Table 5542 below describes the starting and ending position of this segment on each transcript. Table 5542 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724_P21 and T19724_P23.

Segment cluster T19724_node_72 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38 and T19724_T41. Table 5543 below describes the starting and ending position of this segment on each transcript.

Table 5543 - Segment location on transcripts

This segment can be found in a non-coding region of transcrip t(s) that are related to the following protein(s): T19724_P21 and T19724_P23. Segment cluster T19724_node_76 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38 and Tl 9724_T41. Table 5544 below describes the starting and ending position of this segment on each transcript.

Table 5544 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724_P21 and T19724_P23.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T19724_node_49 according to the present invention can be found in the following transcript(s): T19724_T38. Table 5545 below describes the starting and ending position of this segment on each transcript.

Table 5545 - Segment location on transcripts

This segment can be found in the following protein(s): T19724JP21.

Segment cluster T19724_node_52 according to the present invention is supported by 113 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38. Table 5546 below describes the starting and ending position of this segment on each transcript.

Table 5546 - Segment location on transcripts

This segment can be found in the following protein(s): T19724_P21.

Segment cluster T19724_node_53 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38. Table 5547 below describes the starting and ending position of this segment on each transcript.

Table 5547 - Segment location on transcripts

This segment can be found in the following protein(s): T19724_P21.

Segment cluster T19724_node_54 according to the present invention can be found in the following transcript(s): T19724_T38. Table 5548 below describes the starting and ending position of this segment on each transcript.

Table 5548 - Segment location on transcripts

This segment can be found in the following protein(s): T19724_P21.

Segment cluster T19724_node_60 according to the present invention can be found in the following transcript(s): T19724_T38. Table 5549 below describes the starting and ending position of this segment on each transcript. Table 5549 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T19724JP21.

Segment cluster T19724_node_61 according to the present invention can be found in the following transcript(s): T19724_T38. Table 5550 below describes the starting and ending position of this segment on each transcript.

Table 5550 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T19724_P21.

Segment cluster T19724_node_63 according to the present invention can be found in the following transcript(s): T19724_T38. Table 5551 below describes the starting and ending position of this segment on each transcript.

Table 5551 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : Tl 9724_P21.

Segment cluster T19724_node_66 according to the present invention can be found in the following transcript(s): T19724_T38. Table 5552 below describes the starting and ending position of this segment on each transcript. Table 5552 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T19724_P21.

Segment cluster T19724__node_67 according to the present invention can be found in the following trans crip t(s): T19724_T38. Table 5553 below describes the starting and ending position of this segment on each transcript.

Table 5553 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T19724JP21.

Segment cluster T19724_node_68 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38 and T19724_T41. Table 5554 below describes the starting and ending position of this segment on each transcript.

Table 5554 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724_P21 and T19724_P23. Segment cluster T19724_node_69 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38 and T19724_T41. Table 5555 below describes the starting and ending position of this segment on each transcript.

Table 5555 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724_P21 and T19724_P23.

Segment cluster T19724_node_71 according to the present invention is supported by 46 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T19724_T38 and T19724_T41. Table 5556 below describes the starting and ending position of this segment on each transcript.

Table 5556 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T19724_P21 and T19724_P23.

Segment cluster Tl 9724_node_73 according to the present invention can be found in the following transcript(s): T19724_T38 and T19724_T41. Table 5557 below describes the starting and ending position of this segment on each transcript.

Table 5557 - Segment location on transcripts

T 19724 T41 881 892

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724_P21 and T19724JP23.

Segment cluster T19724_node_74 according to the present invention can be found in the following transcript(s): T19724_T38 and T19724_T41. Table 5558 below describes the starting and ending position of this segment on each transcript.

Table 5558 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724_P21 and T19724_P23.

Segment cluster T19724_node_75 according to the present invention can be found in the following transcript(s): T19724_T38 and T19724_T41. Table 5559 below describes the starting and ending position of this segment on each transcript.

Table 5559 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T19724_P21 and T19724JP23.

DESCRIPTION FOR CLUSTER T46984 Cluster T46984 features 5 transcript(s) and 39 segment(s) of interest, the names for which are given in Tables 5560 and 5561, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5562.

Table 5560 - Transcripts of interest

Transcript Name

T46984 PEA 1 T27

T46984 PEA 1 T46

T46984 PEA 1 T51

T46984 PEA 1 T52

T46984 PEA 1 T54

Table 5561 - Segments of interest

Segment Name

T46984 PEA 1 node 6

T46984 PEA 1 node 12

T46984 PEA 1 node 25

T46984 PEA 1 node 46

T46984 PEA 1 node 47

T46984 PEA 1 node 65

T46984 PEA 1 node 69

T46984 PEA 1 node 86

T46984 PEA 1 node 9

T46984 PEA 1 node 13

T46984 PEA 1 node 19

T46984 PEA 1 node 21

T46984 PEA 1 node 22

T46984 PEA 1 node 26

T46984_ _PEA_ _1_ node_ _.28

T46984 PEA 1 node 31

T46984 PEA 1 node 32

T46984 PEA 1 node 38

T46984 PEA 1 node 39

T46984 PEA 1 node 40

T46984 PEA 1 node 42

T46984 PEA 1 node 43

T46984 PEA 1 node 48

T46984 PEA 1 node 49 T46984 PEA 1 node 50

T46984 PEA 1 node 55

T46984 PEA 1 node 57

T46984 PEA 1 node 60

T46984 PEA 1 node 62

T46984 PEA 1 node 66

T46984 PEA 1 node 61

T46984 PEA 1 node 70

T46984 PEA 1 node 71

T46984 _PEA_ 1 node_ 72

T46984 PEA 1 node 73

T46984 PEA 1 node 74

T46984 PEA 1 node 83

T46984 PEA 1 node 84

T46984 PEA 1 node 85

Table 5562 - Proteins of interest

These sequences are variants of the known protein Dolichyl-diphosphooligosaccharide-- protein glycosyltransferase 63 kDa subunit precursor (SwissProt accession identifier

RIB2_HUMAN; known also according to the synonyms EC 2.4.1.119; Ribophorin II; RPN-II; RIBIIR), referred to herein as the previously known protein.

Protein Dolichyl-diphosphooligosaccharide— protein glycosyltransferase 63 kDa subunit precursor is known or believed to have the following function(s): Essential subunit of N- oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid- linked oligosaccharide donor to an asparagine residue within an Asn-X-SerAThr consensus motif in nascent polypeptide chains. The sequence for protein Dolichyl-diphosphooligosaccharide— protein glycosyltransferase 63 kDa subunit precursor is given at the end of the application, as "Dolichyl-diphosphooligosaccharide— protein glycosyltransferase 63 kDa subunit precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5563.

Table 5563 - Amino acid mutations for Known Protein

SNP position(s) on Comment amino acid sequence

Protein Dolichyl-diphosphooligosaccharide— protein glycosyltransferase 63 kDa subunit precursor localization is believed to be Type I membrane protein. Endoplasmic reticulum.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein modification, which are annotation(s) related to Biological Process; oligosaccharyl transferase; dolichyl-diphosphooligosaccharide-protein glycosyltransferase; transferase, which are annotation(s) related to Molecular Function; and oligosaccharyl transferase complex; integral membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster T46984 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 134 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 134 and Table 5564. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues, breast malignant tumors, ovarian carcinoma and pancreas carcinoma.

Table 5564 - Normal tissue distribution

Table 5565 - P values and ratios for expression in cancerous tissue

As noted above, cluster T46984 features 39 segment(s), which were listed in Table 5561 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T46984JPEA_l_node_6 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5566 below describes the starting and ending position of this segment on each transcript.

Table 5566 - Segment location on transcripts

This segment can be found in the following protein(s): T46984JPEA_1_P21.

Segment cluster T46984JPEA_l_node_12 according to the present invention is supported by 262 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5567 below describes the starting and ending position of this segment on each transcript.

Table 5567 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_25 according to the present invention is supported by 257 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5568 below describes the starting and ending position of this segment on each transcript.

Table 5568 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_46 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T46. Table 5569 below describes the starting and ending position of this segment on each transcript.

Table 5569 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T46984_PEA_l_node_47 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T46. Table 5570 below describes the starting and ending position of this segment on each transcript.

Table 5570 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T46984_PEA_l_node_65 according to the present invention is supported by 2 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T46984JPEA_1_T51. Table 5571 below describes the starting and ending position of this segment on each transcript.

Table 5571 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T46984_PEA_l_node_69 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): T46984JPEA_1_T52 and T46984_PEA_1_T54. Table 5572 below describes the starting and ending position of this segment on each transcript.

Table 5572 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T46984_PEA_l_node_86 according to the present invention is supported by 314 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984JPEA_1_T27, T46984_PEA_1_T46, T46984_PEA_1_T51, T46984JPEA_1_T52 and T46984_PEA_1_T54. Table 5573 below describes the starting and ending position of this segment on each transcript.

Table 5573 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T46984_PEA_1_P21.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T46984_PEA_l_node_9 according to the present invention is supported by 304 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5574 below describes the starting and ending position of this segment on each transcript.

Table 5574 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_13 according to the present invention is supported by 232 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5575 below describes the starting and ending position of this segment on each transcript.

Table 5575 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_19 according to the present invention is supported by 237 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5576 below describes the starting and ending position of this segment on each transcript.

Table 5576 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_21 according to the present invention is supported by 242 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5577 below describes the starting and ending position of this segment on each transcript.

Table 5577 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_22 according to the present invention is supported by 205 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5578 below describes the starting and ending position of this segment on each transcript.

Table 5578 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_26 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27. Table 5579 below describes the starting and ending position of this segment on each transcript. Table 5579 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_ 1_P21.

Segment cluster T46984_PEA_l_node_28 according to the present invention is supported by 242 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5580 below describes the starting and ending position of this segment on each transcript.

Table 5580 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_31 according to the present invention is supported by 207 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5581 below describes the starting and ending position of this segment on each transcript.

Table 5581 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984JPEA_l_node_32 according to the present invention is supported by 226 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5582 below describes the starting and ending position of this segment on each transcript.

Table 5582 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_38 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27. Table 5583 below describes the starting and ending position of this segment on each transcript.

Table 5583 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_ 1_P21.

Segment cluster T46984_PEA_l_node_39 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27. Table 5584 below describes the starting and ending position of this segment on each transcript. Table 5584 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_40 according to the present invention is supported by 227 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27. Table 5585 below describes the starting and ending position of this segment on each transcript.

Table 5585 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_42 according to the present invention is supported by 239 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984J^»EA_1_T27. Table 5586 below describes the starting and ending position of this segment on each transcript.

Table 5586 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_ 1_P21.

Segment cluster T46984_PEA_l_node_43 according to the present invention is supported by 235 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984JPEA_1_T27. Table 5587 below describes the starting and ending position of this segment on each transcript. Table 5587 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_48 according to the present invention is supported by 282 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27 and T46984_PEA_1_T46. Table 5588 below describes the starting and ending position of this segment on each transcript.

Table 5588 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_49 according to the present invention is supported by 262 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27 and T46984_PEA_1_T46. Table 5589 below describes the starting and ending position of this segment on each transcript.

Table 5589 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_1 jnode_50 according to the present invention is supported by 277 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27 and T46984_PEA_1_T46. Table 5590 below describes the starting and ending position of this segment on each transcript.

Table 5590 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_55 according to the present invention is supported by 335 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27 and T46984_PEA_1_T46. Table 5591 below describes the starting and ending position of this segment on each transcript.

Table 5591 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_57 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27 and T46984JPEA_ 1_T46. Table 5592 below describes the starting and ending position of this segment on each transcript.

Table 5592 ~ Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21. Segment cluster T46984_PEA_l_node_60 according to the present invention is supported by 326 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27 and T46984_PEA_1_T46. Table 5593 below describes the starting and ending position of this segment on each transcript.

Table 5593 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l__node_62 according to the present invention is supported by 335 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_J_T27 and T46984JPEA_1_T46. Table 5594 below describes the starting and ending position of this segment on each transcript.

Table 5594 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1JP21.

Segment cluster T46984_PEA_l_node_66 according to the present invention is supported by 336 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27, T46984_PEA_1_T46 and T46984_PEA_1_T51. Table 5595 below describes the starting and ending position of this segment on each transcript.

Table 5595 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_ l_node_67 according to the present invention is supported by 323 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T46984_PEA_1_T27, T46984JPEA_1_T46 and T46984_PEA_1_T51. Table 5596 below describes the starting and ending position of this segment on each transcript.

Table 5596 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_70 according to the present invention is supported by 337 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984JPEA_1_T27, T46984_PEA_1_T46, T46984_PEA_1_T51, T46984_PEA_1_T52 and T46984_PEA_1_T54. Table 5597 below describes the starting and ending position of this segment on each transcript.

Table 5597 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21. Segment cluster T46984_PEA_l_node_71 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27, T46984_PEA_1_T46, T46984JPEA_1_T51, T46984_PEA_1_T52 and T46984_PEA_1_T54. Table 5598 below describes the starting and ending position of this segment on each transcript.

Table 5598 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_72 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27, T46984_PEA_1_T46, T46984_PEA_1_T51, T46984_PEA_1_T52 and T46984_PEA_1_T54. Table 5599 below describes the starting and ending position of this segment on each transcript.

Table 5599 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_73 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27, T46984_PEA_1_T46, T46984_PEA_1_T51, T46984_PEA_1_T52 and T46984_PEA_1_T54. Table 5600 below describes the starting and ending position of this segment on each transcript. Table 5600 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_74 according to the present invention can be found in the following transcript(s): T46984JPEA_1_T27, T46984_PEA_1_T46, T46984_PEA_1_T51, T46984_PEA_1_T52 and T46984_PEA_1_T54. Table 5601 below describes the starting and ending position of this segment on each transcript.

Table 5601 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_83 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27, T46984JPEA_1_T46, T46984_PEA_1_T51 , T46984_PEA_1_T52 and T46984_PEA_1_T54. Table 5602 below describes the starting and ending position of this segment on each transcript.

Table 5602 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1_P21.

Segment cluster T46984_PEA_l_node_84 according to the present invention can be found in the following transcript(s): T46984_PEA_1_T27, T46984JPEA_1_T46, T46984JPEAJ_T51, T46984_PEA_1_T52 and T46984JPEA_1_T54. Table 5603 below describes the starting and ending position of this segment on each transcript.

Table 5603 - Segment location on transcripts

This segment can be found in the following protein(s): T46984_PEA_1JP21.

Segment cluster T46984_PEA_l_node_85 according to the present invention is supported by 295 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T46984JPEA_1_T27, T46984_PEA_1_T46, T46984_PEA_1_T51 , T46984_PEA_1_T52 and T46984_PEA_1_T54. Table 5604 below describes the starting and ending position of this segment on each transcript.

Table 5604 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T46984_PEA_1_P21.

DESCRIPTION FOR CLUSTER T47019

Cluster T47019 features 16 transcript(s) and 20 segment(s) of interest, the names for which are given in Tables 5605 and 5606, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5607.

Table 5605 - Transcripts of interest

Transcript Name -

T47019 TO

T47019 Tl

T47019 T2

T47019 T3

T47019 T4

T47019 T5

T47019 T6

T47019 T7

T47019 T8

T47019 TlO

T47019 TI l

T47019 T12

T47019 T14

T47019 T15

T47019 T17

T47019 T20

Table 5606 - Segments of interest

Segment Name

T47019 node 0

T47019 node 3

T47019 node 6 T47019 node 7

T47019 node 16

T47019 node 21

T47019 node 1

T47019 node 2

T47019 node 4

T47019 node 5

T47019 node 8

T47019 node 9

T47019 node 10

T47019 node 11

T47019 node 12

T47019 node 13

T47019 node 14

T47019 node 15

T47019 node 18

T47019 node 20

Table 5607 - Proteins of interest

These sequences are variants of the known protein Calcyclin (SwissProt accession identifier S106_HUMAN; known also according to the synonyms Prolactin receptor associated protein; PRA; Growth factor- inducible protein 2A9; SlOO calcium-binding protein A6; MLN 4), referred to herein as the previously known protein.

The sequence for protein Calcyclin is given at the end of the application, as "Calcyclin amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5608. Table 5608 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell cycle control; cell- cell signaling; axonogenesis, which are annotation(s) related to Biological Process; calcium binding; protein binding; growth factor, which are annotation(s) related to Molecular Function; and nuclear membrane, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster T47019 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 135 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to tie histograms in Figure 135 and Table 5609. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: pancreas carcinoma. Table 5609 - Normal tissue distribution

Table 5610 - P values and ratios for expression in cancerous tissue

As noted above, cluster T47019 features 20 segment(s), which were listed in Table 5606 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A descriptbn of each segment according to the present invention is now provided.

Segment cluster T47019_node_0 according to the present invention is supported by 67 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T47019_T0, T47019_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47019_T11, T47019_T12, T47019_T14, T47019_T15, T47019_T17 and T47019_T20. Table 5611 below describes the starting and ending position of this segment on each transcript.

Table 5611 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P2, T47019JP3, T47019JP4 and T47019_P6. This segment can also be found in the following protein(s): T47019_P9, since it is in the coding region for the corresponding transcript.

Segment cluster T47019_node_3 according to the present invention is supported by 654 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T0, T47O19_T1, T47019_T2, T47019_T3, T47019_T5, T47019_T10, T47019JN 1, T47019_T12, T47019_T14, T47019_T15, T47019_T17 and T47019_T20. Table 5612 below describes the starting and ending position of this segment on each transcript.

Table 5612 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T47019_P2, T47019_P3, T47019_P4, T47019_P6 and T47019_P9.

Segment cluster T47019_node_6 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T11 and T47019_T17. Table 5613 below describes the starting and ending position of this segment on each transcript. Table 5613 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T47019_P2, T47019_P3 and T47019_P4.

Segment cluster T47019_node_7 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T3, T47019_T4, T47019_T11 and T47019_T17. Table 5614 below describes the starting and ending position of this segment on each transcript.

Table 5614 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P2 and T47019_P4. This segment can also be found in the following protein(s): T47019_P3, since it is in the coding region for the corresponding transcript.

Segment cluster T47019_node_16 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T12, T47019_T15 and T47019_T17. Table 5615 below describes the starting and ending position of this segment on each transcript. Table 5615 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5616.

Table 5616 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): T47019_P4.

Segment cluster T47019_node_21 according to the present invention is supported by 592 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T0, T47019_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47019_T11, T47019_T12, T47019_T14, T47019_T15, T47019_T17 and T47019_T20. Table 5617 below describes the starting and ending position of this segment on each transcript.

Table 5617 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P3, T47019_P4 and T47019_P9. This segment can also be found in the following protein(s): T47019_P2 and T47019_P6, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T47019_node_l according to the present invention can be found in the following transcript(s): T47019_T0, T47O19_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47O19_T11, T47019_T12, T47019_T14, T47019_T15, T47019_T17 and T47019_T20. Table 5618 below describes the starting and ending position of this segment on each transcript.

Table 5618 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T47019_P2, T47019_P3, T47019_P4, T47019_P6 and T47019_P9.

Segment cluster T47019_node_2 according to the present invention can be found in the following transcript(s): T47019_T0, T47O19_T1, T47019_T2, T47019_T3, T47019_T5, T47019_T6, T47019_T10, T47O19_T11, T47019_T12, T47019_T14, T47019_T15, T47019_T17 and T47019_T20. Table 5619 below describes the starting and ending position of this segment on each transcript.

Table 5619 - Segment location on transcripts

This segment can be found in a non-coding region of transcriρt(s) that are related to the following protein(s): T47019_P2, T47019_P3, T47019_P4, T47019_P6 and T47019_P9. Segment cluster T47019_node_4 according to the present invention can be found in the following transcript(s): T47019_T3, T47019_T5, T47O19_T11 and T47019_T17. Table 5620 below describes the starting and ending position of this segment on each transcript.

Table 5620 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T47019_P2, T47019_P3 and T47019_P4.

Segment cluster T47019_node_5 according to the present invention can be found in the following transcript(s): T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47O19_T11 and T47019_T17. Table 5621 below describes the starting and ending position of this segment on each transcript.

Table 5621 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P2, T47019_P3 and T47019JP4.

Segment cluster T47019_node_8 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T3, T47019_T4 and T47019_T17. Table 5622 below describes the starting and ending position of this segment on each transcript.

Table 5622 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P2 and T47019_P4.

Segment cluster T47019_node_9 according to the present invention can be found in the following transcript(s): T47019_T2, T47019_T3, T47019_T4, T47019JN0 and T47019_T17. Table 5623 below describes the starting and ending position of this segment on each transcript.

Table 5623 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T47019_P2 and T47019_P4.

Segment cluster T47019_node_10 according to the present invention is supported by 747 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T0, T47O19_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47019_T12, T47019_T14, T47019_T15 and T47019_T17. Table 5624 below describes the starting and ending position of this segment on each transcript. Table 5624 - Segment location on transcripts

This segment can be found in the following protein(s): T47019_P2, T47019_P4 and T47019 P6.

Segment cluster T47019_node_ll according to the present invention can be found in the following transcript(s): T47019JTO, T47O19_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47019_T12, T47019_T14, T47019_T15 and T47019_T17. Table 5625 below describes the starting and ending position of this segment on each transcript.

Table 5625 - Segment location on transcripts

This segment can be found in the following protein(s): T47019_P2, T47019_P4 and T47019 P6.

Segment cluster T47019_node_12 according to the present invention is supported by 775 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T0, T47O19_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47O19_T11, T47019JN2, T47019_T14, T47019_T15 and T47019_T17. Table 5626 below describes the starting and ending position of this segment on each transcript.

Table 5626 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019JP3. This segment can also be found in the following protein(s): T47019_P2, T47019_P4 and T47019_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T47019__node_13 according to the present invention can be found in the following transcript(s): T47019_T0, T47O19_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47019_T1 1, T47019_T12, T47019_T14, T47019_T15 and T47019_T17. Table 5627 below describes the starting and ending position of this segment on each transcript.

Table 5627 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P3. This segment can also be found in the following protein(s): T47019_P2, T47019_P4 and T47019_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T47019_node_14 according to the present invention is supported by 789 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T0, T47O19_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47019_T1 1, T47019_T12, T47019_T14, T47019_T15 and T47019_T17. Table 5628 below describes the starting and ending position of this segment on each transcript.

Table 5628 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P3. This segment can also be found in the following protein(s): T47019JP2, T47019_P4 and T47019_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T47019_node_15 according to the present invention can be found in the following transcript(s): T47019_T0, T47O19_T1, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47O19_T11, T47019_T12, T47019_T14, T47019_T15 and T47019_T17. Table 5629 below describes the starting and ending position of this segment on each transcript.

Table 5629 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P3. This segment can also be ibund in the following protein(s): T47019_P2, T47019JP4 and T47019_P6, since it is in the coding region for the corresponding transcript.

Segment cluster T47019_node_18 according to the present invention can be found in the following transcript(s): T47019_T0, T47019JN, T47019_T2, T47019_T3, T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47019_T11, T47019_T12, T47019_T15, T47019_T17 and T47019_T20. Table 5630 below describes the starting and ending position of this segment on each transcript.

Table 5630 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P3, T47019_P4 and T47019_P9. This segment can also be found in the following protein(s): T47019_P2, since it is in the coding region for the corresponding transcript.

Segment cluster T47019_node_20 according to the present invention is supported by 779 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T47019_T0, T47019_T1, T47019_T2, T47019_T3,

T47019_T4, T47019_T5, T47019_T6, T47019_T7, T47019_T8, T47019_T10, T47O19_T11, T47019_T12, T47019_T14, T47019_T15, T47019_T17 and T47019_T20. Table 5631 below describes the starting and ending position of this segment on each transcript.

Table 5631 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T47019_P3, T47019_P4 and T47019_P9. This segment can also be found in the following protein(s): T47019_P2 and T47019_P6, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER T72188

Cluster T72188 features 5 transcript(s) and 24 segment(s) of interest, the names for which are given in Tables 5632 and 5633, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5634.

Table 5632 - Transcripts of interest

TranscriptName

T72188 TlO

T72188 T15

T72188 T19

T72188 T20

T72188 T21

Table 5633 - Segments of interest

SegmentName

T72188 node 0

T72188 node 1

T72188 node 13

T72188 node 18 T72188 node 20

T72188 node 23

T72188 node 24

T72188 node 27

T72188 node 34

T72188 node 35

T72188 node 41

T72188 node 14

T72188 node 15

T72188_node 16

T72188 node 17

T72188 node 21

T72188 node 22

T72188 node 25

T72188 node 28

T72188 node 29

T72188 node 36

T72188 node 37

T72188 node 38

T72188 node 40

Table 5634 - Proteins of interest

These sequences are variants of the known protein Alpha- IB- glycoprotein precursor (SwissProt accession identifier AlBG-HUMAN; known also according to the synonyms Alpha- 1-B glycoprotein), referred to herein as the previously known protein.

Protein Alpha- IB- glycoprotein precursor is known or believed to have the following function(s): Not known. The sequence for protein Alpha- IB- glycoprotein precursor is given at the end of the application, as "Alpha- IB- glycoprotein precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5635.

Table 5635 - Amino acid mutations for Known Protein

Protein Alpha- IB- glycoprotein precursor localization is believed to be Secreted.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: extracellular, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster T72188 features 24 segment(s), which were listed in Table 5633 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T72188_node_0 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T21. Table 5636 below describes the starting and ending position of this segment on each transcript.

Table 5636 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster T72188_node_l according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T21. Table 5637 below describes the starting and ending position of this segment on each transcript.

Table 5637 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster T72188_node_13 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5638 below describes the starting and ending position of this segment on each transcript.

Table 5638 - Segment location on transcripts

This segment can be found in the following protein(s): T72188_P10.

Segment cluster T72188_node_18 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5639 below describes the starting and ending position of this segment on each transcript.

Table 5639 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_20 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5640 below describes the starting and ending position of this segment on each transcript.

Table 5640 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_23 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T15. Table 5641 below describes the starting and ending position of this segment on each transcript.

Table 5641 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_24 according to the present invention is supported by 27 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5642 below describes the starting and ending position of this segment on each transcript. Table 5642 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_27 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5643 below describes the starting and ending position of this segment on each transcript.

Table 5643 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_34 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T19 and T72188_T20. Table 5644 below describes the starting and ending position of this segment on each transcript.

Table 5644 - Segment location on transcripts

This segment can be found in the following protein(s): T72188_P17. Segment cluster T72188_node_35 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10, T72188_T15, T72188_T19 and T72188_T20. Table 5645 below describes the starting and ending position of this segment on each transcript.

Table 5645 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10. This segment can also be found in the following protein(s): T72188_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T72188_node_41 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10, T72188_T15, T72188_T19 and T72188_T20. Table 5646 below describes the starting and ending position of this segment on each transcript.

Table 5646 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10. This segment can also be found in the following protein(s): T72188_P17, since it is in the coding region for the corresponding transcript. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T72188_node_14 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5647 below describes the starting and ending position of this segment on each transcript.

Table 5647 - Segment location on transcripts

This segment can be found in the following protein(s): T72188_P10.

Segment cluster T72188_node_15 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5648 below describes the starting and ending position of this segment on each transcript.

Table 5648 - Segment location on transcripts

This segment can be found in the following protein(s): T72188_P10.

Segment cluster T72188_node_ 16 according to the present invention can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5649 below describes the starting and ending position of this segment on each transcript. Table 5649 - Segment location on transcripts

This segment can be found in the following protein(s): T72188_P10.

Segment cluster T72188_node_17 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5650 below describes the starting and ending position of this segment on each transcript.

Table 5650 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_21 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T15. Table 5651 below describes the starting and ending position of this segment on each transcript.

Table 5651 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10. Segment cluster T72188jnode_22 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T15. Table 5652 below describes the starting and ending position of this segment on each transcript.

Table 5652 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_25 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5653 below describes the starting and ending position of this segment on each transcript.

Table 5653 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_28 according to the present invention can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5654 below describes the starting and ending position of this segment on each transcript.

Table 5654 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_29 according to the present invention can be found in the following transcript(s): T72188_T10 and T72188_T15. Table 5655 below describes the starting and ending position of this segment on each transcript.

Table 5655 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10.

Segment cluster T72188_node_36 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10, T72188_T15, T72188_T19 and T72188_T20. Table 5656 below describes the starting and ending position of this segment on each transcript.

Table 5656 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10. This segment can also be found in the following protein(s): T72188_P17, since it is in the coding region for the corresponding transcript. Segment cluster T72188_node_37 according to the present invention can be found in the following transcript(s): T72188_T10, T72188_T15, T72188_T19 and T72188_T20. Table 5657 below describes the starting and ending position of this segment on each transcript.

Table 5657 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10. This segment can also be found in the following protein(s): T72188_P17, since it is in the coding region for the corresponding transcript.

Segment cluster T72188_node_38 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T72188_T10, T72188_T15, T72188_T19 and T72188_T20. Table 5658 below describes the starting and ending position of this segment on each transcript.

Table 5658 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of txanscript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10. This segment can also be found in the following protein(s): T72188_P17, since it is in the coding region for the corresponding transcript. Segment cluster T72188_node_40 according to the present invention can be found in the following transcript(s): T72188_T10, T72188_T15, T72188_T19 and T72188_T20. Table 5659 below describes the starting and ending position of this segment on each transcript.

Table 5659 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T72188_P10. This segment can also be found in the following protein(s): T72188_P17, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER T99080

Cluster T99080 features 8 transcript(s) and 11 segment(s) of interest, the names for which are given in Tables 5660 and 5661, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5662.

Table 5660 - Transcripts of interest

Transcript Name

T99080 PEA 4 TO

T99080 PEA 4 T2

T99080 PEA 4 T4

T99080 PEA 4 TlO

T99080 PEA 4 TI l

T99080 PEA 4 T13

T99080 PEA 4 T14 T99080 PEA 4 T17

Table 5661 - Segments of interest

Segment Name

T99080 PEA 4 node 1

T99080 PEA 4 node 6

T99080 PEA 4 node 11

T99080 PEA 4 node 19

T99080 PEA 4 node 20

T99080 PEA 4 node 3

T99080 PEA 4 node 5

T99080 PEA 4 node 8

T99080 PEA 4 node 13

T99080 PEA 4 node 15

T99080 PEA 4 node 18

Table 5662 - Proteins of interest

These sequences are variants of the known protein Acylphosphatase, organ- common type iso2yme (SwissProt accession identifier ACYO-HUMAN; known also according to the synonyms EC 3.6.1.7; Acylphosphate phosphohydrolase; Acylphosphatase, erythrocyte isozyme), referred to herein as the previously known protein. Protein Acylphosphatase, organ-common type isozyme is known or believed to have the following function(s): Its physiological role is not yet clear. The sequence for protein Acylphosphatase, organ-common type isozyme is given at the end of the application, as "Acylphosphatase, organ-common type isozyme amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5663. Table 5663 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: phosphate metabolism, which are annotation(s) related to Biological Process; and acylphosphatase, which are annotation(s) related to Molecular Function.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster T99080 features 11 segment(s), which were listed in Table 5661 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster T99080_PEA_4_node_l according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T99080_PEA_4_T0 and T99080_PEA_4_T13. Table 5664 below describes the starting and ending position of this segment on each transcript.

Table 5664 - Segment location on transcripts

This segment can be found in the following protein(s): T99080_PEA_4_Pl. Segment cluster T99080_PEA_4_node_6 according to the present invention is supported by 3 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T99080_JPEA_4_T17. Table 5665 below describes the starting and ending position of this segment on each transcript.

Table 5665 - Segment location on transcripts

This segment can be found in the following protein(s): T99080JPEA 4 P13.

Segment cluster T99080_PEA_4jnode_l 1 according to the present invention is supported by 7 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T99080JPEA_4_T14. Table 5666 below describes the starting and ending position of this segment on each transcript.

Table 5666 - Segment location on transcripts

This segment can be found in the following protein(s): T99080_PEA_4_P12.

Segment cluster T99080JPEA_4_node_19 according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T99080_PEA_4_T0, T99080_PEA_4_T2 and T99080_PEA_4_T4. Table 5667 below describes the starting and ending position of this segment on each transcript.

Table 5667 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T99080_PEA_4JPl and T99080_PEA_4_P2.

Segment cluster T99080_PEA_4_node_20 according to the present invention is supported by 98 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T99080_PEA_4_T0, T99080JPEA_4_T2, T99080_PEA_4_T4, T99080_PEA__4_T10, T99080JPEA_4_Tl l and T99080_PEA_4_T13. Table 5668 below describes the starting and ending position of this segment on each transcript. Table 5668 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T99080_PEA_4_Pl, T99080_PEA_4_P2 and T99080_PEA_4_P10. This segment can also be found in the following protein(s): T99080_PEA_4_P9, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T99080_PEA_4_node_3 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T99080_PEA_4_T2, T99080J^>EA_4_T10, T99080_PEA_4_Tl l, T99080_PEA_4_T14 and T99080_PEA_4_T17. Table 5669 below describes the starting and ending position of this segment on each transcript.

Table 5669 - Segment location on transcripts

This segment can be found in the following protein(s): T99080_PEA_4_P2, T99080_PEA_4_P9, T99080_PEA_4_P10, T99080_PEA_4_P12 and T99080_PEA_4_P13.

Segment cluster T99080_PEA_4_node_5 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T99080_PEA_4_T0, T99080_PEA_4_T2, T99080_PEA_4_T10, T99080_PEA_4_Tl l, T99080_PEA_4_T14 and T99080_PEA_4_T17. Table 5670 below describes the starting and ending position of this segment on each transcript.

Table 5670 - Segment location on transcripts

This segment can be found in the following protein(s): T99080_PEA_4_Pl, T99080_PEA_4_P2, T99080_PEA_4JP9, T99080_PEA_4_P10, T99080JPEA_4_P12 and T99080 PEA 4 P13. Segment cluster T99080_PEA_4_node_8 according to the present invention is supported by 12 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T99080_PEA_4_T10 and T99080_PEA_4_T14. Table 5671 below describes the starting and ending position of this segment on each transcript.

Table 5671 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5672.

Table 5672 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): T99080_PEA_4_P9 and T99080_PEA_4_P12.

Segment cluster T99080_PEA_4_node_13 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T99080_PEA_4_T4. Table 5673 below describes the starting and ending position of this segment on each transcript. Table 5673 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster T99080_PEA_4_node_15 according to the present invention is supported by 6 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): T99O8O_PEA_4JT11. Table 5674 below describes the starting and ending position of this segment on each transcript.

Table 5674 - Segment location on transcripts

This segment can be found in the following protein(s): T99080_PEA_4_P10.

Segment cluster T99080_PEA_4_node_18 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T99080_PEA_4_T0 and T99080_PEA_4_T2. Table 5675 below describes the starting and ending position of this segment on each transcript.

Table 5675 - Segment location on transcripts

This segment can be found in the following protein(s): T99O8O_PEA_4_P1 and T99080 PEA 4 P2.

DESCRIPTION FOR CLUSTER Z20721 Cluster Z20721 features 1 transcript(s) and 6 segment(s) of interest, the names for which are given in Tables 5676 and 5677, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5678.

Table 5676 - Transcripts of interest

Transcript Name

Z20721 T3

Table 5677 - Segments of interest

Segment Name

Z20721 node 5

Z20721 node 14

Z20721 node 17

Z20721 node 18

Z20721 node 6

Z20721 node 12

Table 5678 - Proteins of interest

These sequences are variants of the known protein Interferon- induced protein 6-16 precursor (SwissProt accession identifier INI2_HUMAN; known also according to the synonyms Ifi-6-16), referred to herein as the previously known protein.

The sequence for protein Interferon- induced protein 6-16 precursor is given at the end of the application, as "Interferon- induced protein 6-16 precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5679.

Table 5679 - Amino acid mutations for Known Protein

The previously known protein also has the following indication(s) and/or potential therapeutic use(s): Infection, hepatitis- C virus; Infection, human papilloma virus; Infection, varicella zoster virus; Cancer, head and neck; Infection, otological; Infection, herpes virus; Inflammation, brain; Cancer, leukaemia, hairy cell; Infection, hepatitis virus; Cancer, sarcoma, Kaposi's; Cancer, melanoma; Cancer, myeloma; Cancer, renal; Infection, hepatitis-B virus; Cancer, leukaemia, chronic myelogenous; Cancer, leukaemia; Cancer, lymphoma, T-cell; Infection, HIV/AIDS; Dysplasia, cervical; Multiple sclerosis; Infection, West Nile encephalitis virus; Infection, coronavirus; Infection, coronavirus, prophylaxis; Arthritis, rheumatoid; Infection; Cancer; Cancer, brain; Infection, herpes simplex virus; Cancer, skin; Cirrhosis, hepatic; Macular degeneration; Keratoconjunctivitis; Cancer, colorectal; Cancer, liver; Cancer, sarcoma. It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Interferon alpha 2 agonist; Interferon alpha 2A agonist; Interferon alpha 2b agonist; Interferon alpha 2c agonist; Interferon alpha Nl agonist; Interferon alpha N3 agonist; Interferon alpha agonist; Interferon beta agonist; Interferon gamma Ia agonist; Interferon gamma agonist; Interleukin 2 agonist; Protein synthesis antagonist; RNA synthesis inhibitor. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Antiviral, interferon; Cytokine; Anticancer; Ophthalmological; Antiviral, anti-HIV; Multiple sclerosis treatment; Antiarthritic, immunological; Hepatoprotective.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: immune response, which are annotation(s) related to Biological

Process; and integral membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>. Cluster Z20721 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in noπnal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 136 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 136 and Table 5680. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and breast malignant tumors.

Table 5680 - Normal tissue distribution

Table 5681 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z20721 features 6 seginent(s), which were listed in Table 5677 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z20721_node_5 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z20721_T3. Table 5682 below describes the starting and ending position of this segment on each transcript.

Table 5682 - Segment location on transcripts

This segment can be found in the following protein(s): Z20721 JP3. Segment cluster Z20721_node_14 according to the present invention is supported by 173 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z20721_T3. Table 5683 below describes the starting and ending position of this segment on each transcript.

Table 5683 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5684.

Table 5684 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): Z20721_P3.

Segment cluster Z20721_node_17 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z20721_T3. Table 5685 below describes the starting and ending position of this segment on each transcript.

Table 5685 - Segment location on transcripts

This segment can be found in the following protein(s): Z20721_P3.

Segment cluster Z20721_node_18 according to the present invention is supported by 107 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z20721_T3. Table 5686 below describes the starting and ending position of this segment on each transcript.

Table 5686 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z20721_P3.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z20721_node_6 according to the present invention is supported by 165 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z20721_T3. Table 5687 below describes the starting and ending position of this segment on each transcript

Table 5687 - Segment location on transcripts

This segment can be found in the following protein(s): Z20721_P3.

Segment cluster Z20721_node_12 according to the present invention is supported by 171 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z20721_T3. Table 5688 below describes the starting and ending position of this segment on each transcript.

Table 5688 - Segment location on transcripts

This segment can be found in the following protein(s): Z20721_P3.

DESCRIPTION FOR CLUSTER Z28497

Cluster Z28497 features 3 transcript(s) and 21 segment(s) of interest, the names for which are given in Tables 5689 and 5690, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5691. Table 5689 - Transcripts of interest

Transcript Name

Z28497 PEA 1 T16

Z28497 PEA 1 T19

Z28497 PEA 1 T22

Table 5690 - Segments of interest

Segment Name

Z28497 PEA 1 node 7

Z28497 PEA 1 node 8

Z28497 PEA 1 node 9

Z28497 PEA 1 node 11

Z28497 PEA 1 node 21

Z28497 PEA 1 node 30

Z28497 PEA 1 node 31

Z28497 PEA 1 node 34

Z28497 PEA 1 node 35

Z28497 PEA 1 node 10

Z28497 PEA 1 node 14

Z28497 PEA 1 node 15

Z28497 PEA 1 node 16

Z28497 PEA 1 node 18

Z28497 PEA 1 node 22

Z28497 PEA 1 node 23

Z28497 PEA 1 node 26

Z28497 PEA 1 node 27 Z28497 PEA 1 node 28

Z28497 PEA 1 node 29

Z28497 PEA 1 node 32

Table 5691 - Proteins of interest

These sequences are variants of the known protein Calumenin precursor (SwissProt accession identifier CALU-HUMAN; known also according to the synonyms Crocalbin; IEF SSP 9302), referred to herein as the previously known protein.

Protein Calumenin precursor is known or believed to have the following function(s): Not known, binds 7 calcium ions with a low affinity. The sequence for protein Calumenin precursor is given at the end of the application, as "Calumenin precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5692.

Table 5692 - Amino acid mutations for Known Protein

Protein Calumenin precursor localization is believed to be Endoplasmic reticulum lumen and secreted.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: calcium binding, which are annotation(s) related to Molecular Function; and endoplasmic reticulum; Golgi apparatus, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nili.gov/projects/LocusLink/>. Cluster Z28497 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 137 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 137 and Table 5693. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: adrenal cortical carcinoma, colorectal cancer, epithelial malignant tumors, a mixture of malignant tumors from different tissues, hepatocellular carcinoma and malignant tumors involving the lymph nodes.

Table 5693 - Normal tissue distribution

I Uterus I 386 I

Table 5694 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z28497 features 21 segment(s), which were listed in Table 5690 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster Z28497_PEA_l_node_7 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497JPEA_1__T16 and Z28497_PEA_1_T19. Table 5695 below describes the starting and ending position of this segment on each transcript.

Table 5695 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_8 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16 and Z28497_PEA_1_T19. Table 5696 below describes the starting and ending position of this segment on each transcript.

Table 5696 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_9 according to the present invention is supported by 182 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16 and Z28497_PEA_1_T19. Table 5697 below describes the starting and ending position of this segment on each transcript.

Table 5697 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_l l according to the present invention is supported by 59 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T19. Table 5698 below describes the starting and ending position of this segment on each transcript.

Table 5698 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_21 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T22. Table 5699 below describes the starting and ending position of this segment on each transcript.

Table 5699 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z28497_PEA_l_node_30 according to the present invention is supported by 252 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5700 below describes the starting and ending position of this segment on each transcript.

Table 5700 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_31 according to the present invention is supported by 281 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5701 below describes the starting and ending position of this segment on each transcript.

Table 5701 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_34 according to the present invention is supported by 307 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5702 below describes the starting and ending position of this segment on each transcript.

Table 5702 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z28497JPEAJ JP6.

Segment cluster Z28497_PEA_l_node_35 according to the present invention is supported by 415 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5703 below describes the starting and ending position of this segment on each transcript.

Table 5703 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z28497_PEA_1_P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z28497_PEA_l_node_10 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T19. Table 5704 below describes the starting and ending position of this segment on each transcript. Table 5704 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_ 14 according to the present invention is supported by 172 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16 and Z28497_PEA_1_T19. Table 5705 below describes the starting and ending position of this segment on each transcript.

Table 5705 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_15 according to the present invention is supported by 162 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16 and Z28497_PEA_1_T19. Table 5706 below describes the starting and ending position of this segment on each transcript.

Table 5706 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_16 according to the present invention is supported by 143 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16 and Z28497_PEA_1_T19. Table 5707 below describes the starting and ending position of this segment on each transcript.

Table 5707 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497JPEA_1_P6.

Segment cluster Z28497_PEA_l_node_18 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16 and Z28497_PEA_1_T19. Table 5708 below describes the starting and ending position of this segment on each transcript.

Table 5708 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_22 according to the present invention is supported by 142 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5709 below describes the starting and ending position of this segment on each transcript. Table 5709 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_23 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5710 below describes the starting and ending position of this segment on each transcript.

Table 5710 ~ Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_26 according to the present invention is supported by 127 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5711 below describes the starting and ending position of this segment on each transcript.

Table 5711 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_27 according to the present invention can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5712 below describes the starting and ending position of this segment on each transcript.

Table 5712 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_28 according to the present invention is supported by 129 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497JPEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5713 below describes the starting and ending position of this segment on each transcript.

Table 5713 - Segment location on transcripts

This segment can be found in the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_29 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497_PEA_1_T22. Table 5714 below describes the starting and ending position of this segment on each transcript.

Table 5714 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z28497_PEA_1_P6.

Segment cluster Z28497_PEA_l_node_32 according to the present invention is supported by 187 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z28497_PEA_1_T16, Z28497_PEA_1_T19 and Z28497JPEA_1_T22. Table 5715 below describes the starting and ending position of this segment on each transcript. Table 5715 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z28497_PEA_1_P6.

DESCRIPTION FOR CLUSTER Z38148

Cluster Z38148 features 17 transcript(s) and 29 segment(s) of interest, the names for which are given in Tables 5716 and 5717, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5718.

Table 5716 - Transcripts of interest

Transcript Name

Z38148 PEA 1 Tl

Z38148 PEA 1 T2

Z38148 PEA 1 T3

Z38148 PEA 1 T4 Z38148 PEA 1 T5

Z38148 PEA 1 T8

Z38148 PEA 1 T9

Z38148 PEA 1 TlO

Z38148 PEA 1 TI l

Z38148 PEA 1 T12

Z38148 PEA 1 T13

Z38148 PEA 1 T17

Z38148 PEA 1 T18

Z38148 PEA 1_ _T20

Z38148 PEA 1 T21

Z38148 PEA 1 T31

Z38148 PEA 1 T34

Table 5717 - Segments of interest

Segment Name

Z38148 PEA 1 node 1

Z38148 PEA 1 node 2

Z38148 PEA 1 node 3

Z38148 PEA 1 node 4

Z38148 PEA 1 node 9

Z38148 PEA 1 node 10

Z38148 PEA 1 node 13

Z38148 PEA 1 node 14

Z38148 PEA 1 node 16

Z38148 PEA 1 node 20

Z38148 PEA 1 node 22

Z38148 PEA 1 node 26

Z38148 PEA 1 node 29

Z38148 PEA 1 node 30

Z38148 PEA 1 node 31

Z38148 PEA 1 node 34

Z38148_ _PEA_ _.1. node 38

Z38148 PEA 1 node 40

Z38148 PEA 1 node 41

Z38148 PEA 1 node 43

Z38148 PEA 1 node 46

Z38148 PEA 1 node 0

Z38148 PEA 1 node 5

Z38148 PEA 1 node 6

Z38148 PEA 1 node 12

Z38148 PEA 1 node 15

Z38148 PEA 1 node 21 Z38148 PEA 1 node 37

Z38148 PEA 1 node 39

Table 5718 - Proteins of interest

As noted above, cluster Z38148 features 29 segment(s), which were listed in Table 5717 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z38148_PEA_l_node_l according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T8, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_J_T20, Z38148_PEA_1_T21 and Z38148_PEA_1_T31. Table 5719 below describes the starting and ending position of this segment on each transcript

Table 5719 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P5 and Z38148_PEA_1_P8. This segment can also be found in the following protein(s): Z38148_PEA_1_P3, since it is in the coding region for the corresponding transcript.

Segment cluster Z38148_PEA_l_node_2 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T8, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_l_T20, Z38148JPEA_1_T21 and Z38148_PEA_1_T31. Table 5720 below describes the starting and ending position of this segment on each transcript. Table 5720 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P4, Z38148_PEA_1_P5 and Z38148_PEA_1 J^>8. This segment can also be found in the following protein(s): Z38148_PEA_1_P3, since it is in the coding region for the corresponding transcript.

Segment cluster Z38148_PEA_l_node_3 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T3, Z38148_PEA_1_T4 and Z38148_PEA_1_T5. Table 5721 below describes the starting and ending position of this segment on each transcript.

Table 5721 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P4 and Z38148_PEA_1_P5.

Segment cluster Z38148_PEA_l_node_4 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3, Z38148_PEA_1_T4₅ Z38148_PEA_1_T5, Z38148_PEA_1_T8, Z38148_PEAJ_T9, Z38148_PEA_1_T1O, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_1_T2O, Z38148_PEA_1_T21 and Z38148_PEA_1_T31. Table 5722 below describes the starting and ending position of this segment on each transcript. Table 5722 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3, Z38148_PEA_1_P4, Z38148_PEA_1_P5 and Z38148 PEA 1 P8.

Segment cluster Z38148_PEA_l_node_9 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3, Z38148_PEA_1_T8, Z38148_PEA_1_T11, Z38148_PEA_1_T13, Z38148_PEA_1_T21 and Z38148_PEA_1_T31. Table 5723 below describes the starting and ending position of this segment on each transcript.

Table 5723 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3, Z38148_PEA_1_P4 and Z38148_PEA_lJP5.

Segment cluster Z38148JPEA_l_node_10 according to the present invention is supported by 11 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T31. Table 5724 below describes the starting and ending position of this segment on each transcript.

Table 5724 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3.

Segment cluster Z38148_PEA_l_node_13 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2 and Z38148_PEA_1_T3. Table 5725 below describes the starting and ending position of this segment on each transcript.

Table 5725 - Segment location on transcripts

This segment can be fimnd in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3. This segment can also be found in the following protein(s): Z38148_PEA_1_P4, since it is in the coding region for the corresponding transcript.

Segment cluster Z38148_PEA_l_node_14 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3 and Z38148_PEA_1_T8. Table 5726 below describes the starting and ending position of this segment on each transcript.

Table 5726 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3 and Z38148_PEA_1_P4.

Segment cluster Z38148_PEA_l_node_16 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3 and Z38148_PEA_1_T8. Table 5727 below describes the starting and ending position of this segment on each transcript.

Table 5727 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3 and Z38148_PEA_l_P4.

Segment cluster Z38148_PEA_l_node_20 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10 and Z38148_PEA_l_T20. Table 5728 below describes the starting and ending position of this segment on each transcript. Table 5728 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P5 and Z38148_PEA_1_P8.

Segment cluster Z38148_PEA_l_node_22 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_l_T10 and Z38148_PEA_l_T20. Table 5729 below describes the starting and ending position of this segment on each transcript.

Table 5729 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P5. This segment can also be found in the following protein(s): Z38148_PEA_1_P8, since it is in the coding region for the corresponding transcript.

Segment cluster Z38148_PEA_l_node_26 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12 and Z38148_PEA_l_T20. Table 5730 below describes the starting and ending position of this segment on each transcript.

Table 5730 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148JPEA_1_P5. This segment can also be found in the following protein(s): Z38148_PEA_1_P8, since it is in the coding region for the corresponding transcript.

Segment cluster Z38148_PEA_ l_node_29 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T1, Z38148_PEA_1_T17 and Z38148JPEA_1_T18. Table 5731 below describes the starting and ending position of this segment on each transcript.

Table 5731 - Segment location on transcripts

This segment can be found in the following protein(s): Z38148_PEA_1_P2.

Segment cluster Z38148_PEA_l_node_30 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T1, Z38148_PEA_1_T17 and Z38148_PEA_1_T18. Table 5732 below describes the starting and ending position of this segment on each transcript. Table 5732 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P2.

Segment cluster Z38148_PEA_l_node_31 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T1, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_1_T17 and Z38148_PEA_l_T18. Table 5733 below describes the starting and ending position of this segment on each transcript.

Table 5733 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P2. This segment can also be found in the following protein(s): Z38148_PEA_1_P5, since it is in the coding region for the corresponding transcript. Segment cluster Z38148_PEA_l_node_34 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T1, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T1 1, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148JPEA_1_T17, Z38148_PEA_1_T18, Z38148_PEA_l_T20 and Z38148_PEA_1_T21. Table 5734 below describes the starting and ending position of this segment on each transcript.

Table 5734 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P2 and Z38148_PEA_1_P3. This segment can also be found in the following protein(s): Z38148_PEA_1_P5 and Z38148_PEA_1_P8, since it is in the coding region for the corresponding transcript.

Segment cluster Z38148_PEA_l_node_38 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T1, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148JPEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_1_T17, Z38148_PEA_1_T18, Z38148_PEA_l_T20 and Z38148_PEA_1_T21. Table 5735 below describes the starting and ending position of this segment on each transcript.

Table 5735 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P2, Z38148_PEA_1_P5, Z38148_PEA_1_P8 and Z38148 PEA 1 P3.

Segment cluster Z38148_PEA_l_node_40 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148JPEA_1_T1, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_1_T17, Z38148_PEA_1_T18, Z38148_PEA_l_T20 and Z38148_PEA_1_T21. Table 5736 below describes the starting and ending position of this segment on each transcript.

Table 5736 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P2, Z38148_PEA_1_P5, Z38148_PEA_1_P8 and Z38148 PEA 1 P3.

Segment cluster Z38148_PEA_l_node_41 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T1, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148JPEA_1_T13, Z38148_PEA_1_T17, Z38148_PEA_1_T18, Z38148_PEA_l_T20 and Z38148_PEA_1_T21. Table 5737 below describes the starting and ending position of this segment on each transcript.

Table 5737 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P2, Z38148_PEA_1_P5, Z38148_PEA_1_P8 and Z38148_PEA_1_P3.

Segment cluster Z38148_PEA_l_node_43 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T34. Table 5738 below describes the starting and ending position of this segment on each transcript.

Table 5738 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z38148_PEA_l_node_46 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T34. Table 5739 below describes the starting and ending position of this segment on each transcript.

Table 5739 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description. Segment cluster Z38148_PEA_l_node_0 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3, Z38148_PEA_1_T4, Z38148JPEA_1_T5, Z38148_PEA_1_T8, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_l_T20, Z38148_PEA_1_T21 and Z38148_PEA_1_T31. Table 5740 below describes the starting and ending position of this segment on each transcript.

Table 5740 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3, Z38148JPEA_1_P4, Z38148_PEA_1_P5 and Z38148 PEA 1 P8.

Segment cluster Z38148_PEA_l_node_5 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T8, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148JPEA_1_T12, Z38148JPEA_1_T13, Z38148_PEA_l_T20, Z38148_PEA_1_T21 and Z38148_PEA_1_T31. Table 5741 below describes the starting and ending position of this segment on each transcript. Table 5741 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3, Z38148_PEA_1_P4, Z38148JPEAJJP5 and Z38148 PEA 1 P8.

Segment cluster Z38148_PEA_l_node_6 according to the present invention can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3, Z38148_PEA_1_T5, Z38148_PEA_1_TS, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148JPEA._l_T20, Z38148_PEA_1_T21 and Z38148_PEA_1_T31. Table 5742 below describes the starting and ending position of this segment on each transcript.

Table 5742 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3, Z38148_PEA_1_P4, Z38148_PEA_1_P5 and Z38148_PEA_1_P8.

Segment cluster Z38148_PEA_l_node_12 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2 and Z38148_PEA_1_T3. Table 5743 below describes the starting and ending position of this segment on each transcript.

Table 5743 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3 and Z38148_PEA_1_P4.

Segment cluster Z38148_PEA_l_node_15 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T2, Z38148_PEA_1_T3 and Z38148JPEA_1_T8. Table 5744 below describes the starting and ending position of this segment on each transcript. Table 5744 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P3 and Z38148_PEA_1_P4.

Segment cluster Z38148_PEA_l_node_21 according to the present invention can be found in the following transcript(s): Z38148_PEA_1_T9, Z38148_PEA_l_T10 and Z38148_PEA_l_T20. Table 5745 below describes the starting and ending position of this segment on each transcript.

Table 5745 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P5 and Z38148_PEA_l_P8.

Segment cluster Z38148_PEA_l_node_37 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148JPEA_1_T1, Z38148JPEAJ_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148_PEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_1_T17, Z38148_PEA_1_T18, Z38148_PEA_l_T20 and Z38148_PEA_1_T21. Table 5746 below describes the starting and ending position of this segment on each transcript.

Table 5746 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1JP2, Z38148_PEA_1JP5, Z38148_PEA_1_P8 and Z38148 PEA 1 P3.

Segment cluster Z38148_PEA_l_node_39 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38148_PEA_1_T1, Z38148_PEA_1_T4, Z38148_PEA_1_T5, Z38148_PEA_1_T9, Z38148_PEA_l_T10, Z38148JPEA_1_T11, Z38148_PEA_1_T12, Z38148_PEA_1_T13, Z38148_PEA_1_T17, Z38148_PEA_l_T20 and Z38148_PEA_1_T21. Table 5747 below describes the starting and ending position of this segment on each transcript.

Table 5747 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38148_PEA_1_P2, Z38148_PEA_1_P5, Z38148_PEA_1_P8 and Z38148 PEA 1 P3.

DESCRIPTION FOR CLUSTER Z38219

Cluster Z38219 features 3 transcript(s) and 48 segment(s) of interest, the names for which are given in Tables 5748 and 5749, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5750.

Table 5748 - Transcripts of interest

Transcript Name

Z38219 PEA 1 T28

Z38219 PEA 1 T33

Z38219 PEA 1 T43

Table 5749 - Segments of interest

Z38219 PEA 1 node 30

Z38219 PEA 1 node 34

Z38219 PEA 1 node 35

Z38219 PEA 1 node 36

Z38219 PEA 1 node 37

Z38219 PEA 1 node 38

Z38219 PEA 1 node 39

Z38219 PEA 1 node 41

Z38219 PEA 1 node 42

Z38219 PEA 1 node 43

Z38219 PEA 1 node 44

Z38219 PEA 1 node 47

Z38219 PEA 1 node 48

Z38219 PEA 1 node 54

Z38219 PEA 1 node 62

Z38219 PEA 1 node 63

Z38219 PEA 1 node 64

Z38219 PEA 1 node 65

Z38219 PEA 1 node 68

Z38219 PEA 1 node 72

Z38219 PEA 1 node 73

Z38219 PEA 1 node 74

Z38219 PEA 1 node 75

Z38219 PEA 1 node 76

Z38219 PEA 1 node 77

Z38219_. PEA 1 node 79

Z38219 PEA 1 node 80

Z38219 PEA 1 node 82

Z38219 PEA 1 node 85

Z38219 PEA 1 node 86

Table 5750 - Proteins of interest

These sequences are variants of the known protein Heat shock protein 75 kDa, mitochondrial precursor (SwissProt accession identifier TRAL_HUMAN; known also according to the synonyms HSP 75; Tumor necrosis factor type 1 receptor associated protein; TRAP-I; TNFR- associated protein 1), referred to herein as the previously known protein. Protein Heat shock protein 75 kDa, mitochondrial precursor is known or believed to have the following function(s): Chaperone that expresses an ATPase activity. The sequence for protein Heat shock protein 75 kDa, mitochondrial precursor is given at the end of the application, as "Heat shock protein 75 kDa, mitochondrial precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5751.

Table 5751 - Amino acid mutations for Known Protein

Protein Heat shock protein 75 kDa, mitochondrial precursor localization is believed to be Mitochondrial.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein folding, which are annotation(s) related to Biological Process; chaperone; tumor necrosis factor receptor ligand; ATP binding, which are annotation(s) related to Molecular Function; and mitochondrion, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster Z38219 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 138 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 138 and Table 5752. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: colorectal cancer, epithelial malignant tumors, a mixture of malignant tumors from different tissues, lung malignant tumors, malignant tumors involving the lymph nodes, ovarian carcinoma and skin malignancies.

Table 5752 - Normal tissue distribution

Table 5753 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z38219 features 48 segment(s), which were listed in Table 5749 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z38219_PEA_l_node_0 according to the present invention is supported by 154 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5754 below describes the starting and ending position of this segment on each transcript. Table 5754 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_7 according to the present invention is supported by 170 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5755 below describes the starting and ending position of this segment on each transcript.

Table 5755 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_15 according to the present invention is supported by 157 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5756 below describes the starting and ending position of this segment on each transcript.

Table 5756 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_18 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5757 below describes the starting and ending position of this segment on each transcript.

Table 5757 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_19 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5758 below describes the starting and ending position of this segment on each transcript.

Table 5758 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_53 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T43. Table 5759 below describes the starting and ending position of this segment on each transcript.

Table 5759 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1JP32.

Segment cluster Z38219_PEA_l_node_55 according to the present invention is supported by 169 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5760 below describes the starting and ending position of this segment on each transcript.

Table 5760 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_59 according to the present invention is supported by 205 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_ 1_T43. Table 5761 below describes the starting and ending position of this segment on each transcript.

Table 5761 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_84 according to the present invention is supported by 184 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5762 below describes the starting and ending position of this segment on each transcript.

Table 5762 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z38219_PEA_l_node_8 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5763 below describes the starting and ending position of this segment on each transcript.

Table 5763 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_9 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5764 below describes the starting and ending position of this segment on each transcript.

Table 5764 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_ l_node_l 1 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5765 below describes the starting and ending position of this segment on each transcript.

Table 5765 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_12 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5766 below describes the starting and ending position of this segment on each transcript.

Table 5766 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_13 according to the present invention is supported by 155 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5767 below describes the starting and ending position of this segment on each transcript.

Table 5767 - Segment location on transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_17 according to the present invention is supported by 150 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5768 below describes the starting and ending position of this segment on each transcript.

Table 5768 - Segment location on. transcripts

This segment can be found in the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_20 according to the present invention is supported by 161 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219JPEA_1_T33. Table 5769 below describes the starting and ending position of this segment on each transcript.

Table 5769 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_21 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5770 below describes the starting and ending position of this segment on each transcript.

Table 5770 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_28 according to the present invention is supported by 167 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5771 below describes the starting and ending position of this segment on each transcript.

Table 5771 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_30 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5772 below describes the starting and ending position of this segment on each transcript.

Table 5772 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_34 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T33. Table 5773 below describes the starting and ending position of this segment on each transcript.

Table 5773 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_35 according to the present invention is supported by 148 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5774 below describes the starting and ending position of this segment on each transcript. Table 5774 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_36 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219JPEA_1_T33. Table 5775 below describes the starting and ending position of this segment on each transcript.

Table 5775 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_37 according to the present invention is supported by 140 libraries. The number of libraries was determined as previously described. This segment can be found in the following trans cript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5776 below describes the starting and ending position of this segment on each transcript.

Table 5776 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. Segment cluster Z38219_PEA_l_node_38 according to the present invention is supported by 140 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5777 below describes the starting and ending position of this segment on each transcript.

Table 5777 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1JP61.

Segment cluster Z38219_PEA_l_node_39 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219J⁾EA_1_T33. Table 5778 below describes the starting and ending position of this segment on each transcript.

Table 5778 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_41 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5779 below describes the starting and ending position of this segment on each transcript.

Table 5779 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_42 according to the present invention is supported by 130 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5780 below describes the starting and ending position of this segment on each transcript.

Table 5780 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_43 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5781 below describes the starting and ending position of this segment on each transcript.

Table 5781 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. Segment cluster Z38219_PEA_l_node_44 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5782 below describes the starting and ending position of this segment on each transcript.

Table 5782 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_47^r according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5783 below describes the starting and ending position of this segment on each transcript.

Table 5783 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_48 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28 and Z38219_PEA_1_T33. Table 5784 below describes the starting and ending position of this segment on each transcript.

Table 5784 - Segment location on transcripts

Z38219 PEA 1 T33 3431 3474

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61.

Segment cluster Z38219_PEA_l_node_54 according to the present invention is supported by 137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5785 below describes the starting and ending position of this segment on each transcript. Table 5785 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61 and Z38219_PEA_l_P32.

Segment cluster Z38219JPEA_l_node_62 according to the present invention is supported by 185 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5786 below describes the starting and ending position of this segment on each transcript. Table 5786 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1JP32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_63 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and

Z38219_PEA_1_T43. Table 5787 below describes the starting and ending position of this segment on each transcript.

Table 5787 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_64 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5788 below describes the starting and ending position of this segment on each transcript.

Table 5788 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcripts) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219__PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_65 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5789 below describes the starting and ending position of this segment on each transcript.

Table 5789 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_68 according to the present invention is supported by 196 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219JPEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5790 below describes the starting and ending position of this segment on each transcript. Table 5790 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_72 according to the present invention is supported by 194 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219JPEA_1_T33 and Z38219_PEA_1_T43. Table 5791 below describes the starting and ending position of this segment on each transcript.

Table 5791 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_73 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5792 below describes the starting and ending position of this segment on each transcript.

Table 5792 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_74 according to the present invention is supported by 192 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA__1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5793 below describes the starting and ending position of this segment on each transcript.

Table 5793 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_75 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5794 below describes the starting and ending position of this segment on each transcript.

Table 5794 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_76 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and

Z38219_PEA_1_T43. Table 5795 below describes the starting and ending position of this segment on each transcript.

Table 5795 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_77 according to the present invention is supported by 182 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5796 below describes the starting and ending position of this segment on each transcript. Table 5796 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_79 according to the present invention is supported by 169 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z382 l9_PEA_l_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5797 below describes the starting and ending position of this segment on each transcript.

Table 5797 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_ l_node_80 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5798 below describes the starting and ending position of this segment on each transcript.

Table 5798 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_82 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5799 below describes the starting and ending position of this segment on each transcript.

Table 5799 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61. This segment can also be found in the following protein(s): Z38219_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster Z38219_PEA_l_node_85 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5800 below describes the starting and ending position of this segment on each transcript. Table 5800 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61 and Z38219_PEA_1_P32. Segment cluster Z38219_PEA_l_node_86 according to the present invention can be found in the following transcript(s): Z38219_PEA_1_T28, Z38219_PEA_1_T33 and Z38219_PEA_1_T43. Table 5801 below describes the starting and ending position of this segment on each transcript.

Table 5801 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z38219_PEA_1_P61 and Z38219_PEA_1_P32.

DESCRIPTION FOR CLUSTER R00317

Cluster R00317 features 2 transcript(s) and 19 segment(s) of interest, the names for which are given in Tables 5802 and 5803, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5804.

Table 5802 - Transcripts of interest

Transcript Name

R00317 PEA 1 TO

R00317 PEA 1 T4

Table 5803 - Segments of interest

Segment Nam<

R00317 PEA 1 node 0

R00317 PEA 1 node 2

R00317 PEA 1 node 3

R00317 PEA 1 node 4

R00317 PEA 1 node 5

R00317 PEA 1 node 7 R00317 PEA 1 node 14

R00317 PEA 1 node 19

R00317 PEA 1 node 23

R00317 PEA 1 node 25

R00317 PEA 1 node 26

R00317 PEA 1 node 27

R00317 PEA 1 node 30

R00317 PEA 1 node 1

R00317 PEA 1 node 11

R00317_. _PEA_ _1 node _.12

R00317 PEA 1 node 17

R00317 PEA 1 node 21

R00317 PEA 1 node 28

Table 5804 - Proteins of interest

Cluster R00317 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 139 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 139 and Table 5805. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: colorectal cancer, epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 5805 - Normal tissue distribution

Table 5806 - P values and ratios for expression in cancerous tissue

As noted above, cluster R00317 features 19 segment(s), which were listed in Table 5803 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R00317_PEA_ljnode_0 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5807 below describes the starting and ending position of this segment on each transcript.

Table 5807 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_2 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_1_T4. Table 5808 below describes the starting and ending position of this segment on each transcript.

Table 5808 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R00317_PEA_1_P6.

Segment cluster R00317_PEA_l_node_3 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0. Table 5809 below describes the starting and ending position of this segment on each transcript.

Table 5809 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protem(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_4 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0. Table 5810 below describes the starting and ending position of this segment on each transcript.

Table 5810 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_5 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_1_T4. Table 5811 below describes the starting and ending position of this segment on each transcript.

Table 5811 - Segment location on transcripts

This segment can be found in the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_7 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5812 below describes the starting and ending position of this segment on each transcript.

Table 5812 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5813.

Table 5813 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_14 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5814 below describes the starting and ending position of this segment on each transcript.

Table 5814 - Segment location on transcripts

This segment can be found in the following protein(s): ROO317_PEA_1JP6.

Segment cluster R00317_PEA_l_node_19 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5815 below describes the starting and ending position of this segment on each transcript.

Table 5815 - Segment location on transcripts

This segment can be found in the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_23 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317JPEA_l_T0 and R00317_PEA_l_T4. Table 5816 below describes the starting and ending position of this segment on each transcript.

Table 5816 - Segment location on transcripts

This segment can be found in the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_25 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5817 below describes the starting and ending position of this segment on each transcript.

Table 5817 - Segment location on transcripts

This segment can be found in the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_26 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5818 below describes the starting and ending position of this segment on each transcript.

Table 5818 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R00317_PEA_ l_P6.

Segment cluster R00317_PEA_l_node_27 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_1_T4. Table 5819 below describes the starting and ending position of this segment on each transcript.

Table 5819 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R00317_PEA_1_P6.

Segment cluster R00317_PEA_l_node_30 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5820 below describes the starting and ending position of this segment on each transcript.

Table 5820 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : R00317_PEA_1_P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R00317_PEA_l_node_l according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5821 below describes the starting and ending position of this segment on each transcript.

Table 5821 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_l l according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5822 below describes the starting and ending position of this segment on each transcript.

Table 5822 - Segment location on transcripts

This segment can be found in the following protein(s): R00317_PEA_l_P6. Segment cluster R00317_PEA_l_node_12 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5823 below describes the starting and ending position of this segment on each transcript.

Table 5823 - Segment location on transcripts

This segment can be found in the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_17 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l_T4. Table 5824 below describes the starting and ending position of this segment on each transcript.

Table 5824 - Segment location on transcripts

This segment can be found in the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_21 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_1_T4. Table 5825 below describes the starting and ending position of this segment on each transcript.

Table 5825 - Segment location on transcripts

R00317 PEA 1 T4 1614 1716

This segment can be found in the following protein(s): R00317_PEA_l_P6.

Segment cluster R00317_PEA_l_node_28 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R00317_PEA_l_T0 and R00317_PEA_l__T4. Table 5826 below describes the starting and ending position of this segment on each transcript.

Table 5826 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R00317_PEA_l_P6.

DESCRIPTION FOR CLUSTER D12335

Cluster D12335 features 26 transcript(s) and 57 segment(s) of interest, the names for which are given in Tables 5827 and 5828, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5829.

Table 5827 - Transcripts of interest

Transcript Name

D12335 PEA 1_ _T0

D12335 PEA 1 Tl

D12335 PEA 1 T2

D12335 PEA 1 T3

D12335 PEA 1 T₄

Table 5828 - Segments of interest

D12335 PEA 1 node 13

D12335 PEA 1 node 14

D12335 PEA 1 node 15

D12335 PEA 1 node 16

D12335 PEA 1 node 18

D12335 PEA 1 node 19

D12335 PEA 1 node 21

D12335 PEA 1 node 23

D12335 PEA 1 node 26

D12335_ PEA 1 node _27

D12335 PEA 1 node 31

D12335 PEA 1 node 37

D12335 PEA 1 node 38

D12335 PEA 1 node 40

D12335 PEA 1 node 41

D12335 PEA 1 node 42

D12335 PEA 1 node 43

D12335 PEA 1 node 44

D12335 PEA 1 node 45

D12335 PEA 1 node 46

D12335 PEA 1 node 47

D12335 PEA 1 node 48

D12335 PEA 1 node 49

D12335 PEA 1 node 50

D12335 PEA 1 node 51

D12335_ PEA 1 node _52

D12335 PEA 1 node 53

D12335 PEA 1 node 54

D12335 PEA 1 node 55

D12335 PEA 1 node 56

D12335 PEA 1 node 57

D12335 PEA 1 node 58

D12335 PEA 1 node 59

D12335 PEA 1 node 60

D12335 PEA 1 node 61

D12335 PEA 1 node 62

D12335 PEA 1 node 63

D12335 PEA 1 node 65

Table 5829 - Proteins of interest

These sequences are variants of the known protein Pyrroline-5-carboxylate reductase (SwissProt accession identifier PROC_HUMAN; known also according to the synonyms EC 1.5.1.2; P5CR; P5C reductase), referred to herein as the previously known protein.

The sequence for protein Pyrroline-5-carboxylate reductase is given at the end of the application, as 'Pyrroline-5-carboxylate reductase amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5830.

Table 5830 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: proline biosynthesis, which are annotation(s) related to Biological Process; and pyrroline 5-carboxylate reductase; oxidoreductase, which are annotation(s) related to Molecular Function. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLinlc/>.

Cluster D12335 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 140 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 140 and Table 5831. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: brain malignant tumors, epithelial malignant tumors, a mixture of malignant tumors from different tissues, kidney malignant tumors, hepatocellular carcinoma, lung malignant tumors, malignant tumors involving the lymph nodes and gastric carcinoma.

Table 5831 - Normal tissue distribution

Table 5832 - P values and ratios for expression in cancerous tissue

As noted above, cluster D12335 features 57 segment(s), which were listed in Table 5828 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster D12335_PEA_l_node_0 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T42. Table 5833 below describes the starting and ending position of this segment on each transcript.

Table 5833 - Segment location on transcripts

This segment can be found in the following protein(s): D12335_PEA_1_P19.

Segment cluster D12335_PEA_l_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T28 and D12335_PEA_l_T40. Table 5834 below describes the starting and ending position of this segment on each transcript.

Table 5834 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P7 and D12335_PEA_l_P17.

Segment cluster D12335_PEA_l_node_4 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T29. Table 5835 below describes the starting and ending position of this segment on each transcript.

Table 5835 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P7.

Segment cluster D12335_PEA_l_node_7 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T28 and D12335_PEA_l_T40. Table 5836 below describes the starting and ending position of this segment on each transcript.

Table 5836 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P7. This segment can also be found in the following protein(s): D12335_PEA_1_P17, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_9 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T40. Table 5837 below describes the starting and ending position of this segment on each transcript. Table 5837 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P17. Segment cluster D12335_PEA_l_node_10 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T40. Table 5838 below describes the starting and ending position of this segment on each transcript.

Table 5838 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335JPEA_1_P17.

Segment cluster D12335_PEA_l_node_17 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T5, D12335JPEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335JPEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335JPEA_ l_T30, D12335JPEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5839 below describes the starting and ending position of this segment on each transcript.

Table 5839 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335JPEAJJP11, D12335_PEA_1_P12, D12335_PEA_1_P15 and D12335_PEA_1_P16.

Segment cluster D12335_PEA_l_node_25 according to the present invention is supported by 155 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5840 below describes the starting and ending position of this segment on each transcript.

Table 5840 - Segment location on transcripts

This segment can be found in the following protein(s): D12335_PEA_1__P1, D12335_PEA_l_P20, D12335_PEA_1JP5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335_PEA_1_P15 and D12335_PEA_1_P16.

Segment cluster D12335JPEA_l_node_28 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T32. Table 5841 below describes the starting and ending position of this segment on each transcript.

Table 5841 - Segment location on transcripts

This segment can be found in the following protein(s): D12335_PEA_1_P21.

Segment cluster D12335_PEA_l_node_29 according to the present invention is supported by 166 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335JPEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335JPEA_1_T35, D12335_PEA_1_T36 and D12335_PEA_1_T38. Table 5842 below describes the starting and ending position of this segment on each transcript.

Table 5842 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P21. This segment can also be found in the following protein(s): D12335JPEAJJP1, D12335_PEA_l_P20, D12335_PEA__1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335_PEA_1_P13 and D12335_PEA_1_P15, since it is in the coding region for the corresponding transcript. Segment cluster D12335_PEA_l_node_32 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T38. Table 5843 below describes the starting and ending position of this segment on each transcript.

Table 5843 - Segment location on transcripts

This segment can be found in the following protein(s): D12335_PEA_1_P15.

Segment cluster D12335JPEA_l_node_34 according to the present invention is supported by 115 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335JPEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335J^>EA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T35 and D12335_PEA_1_T36. Table 5844 below describes the starting and ending position of this segment on each transcript.

Table 5844 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P21. This segment can also be found in the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P12 and D12335_PEA_1_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_35 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T35. Table 5845 below describes the starting and ending position of this segment on each transcript.

Table 5845 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5846.

Table 5846 - Oligonucleotides related to this segment

This segment can be found in the following protein(s): D12335_PEA_1_P12. Segment cluster D12335_PEA_l_node_39 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335JPEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T31, D12335JPEA__1_T32, D12335_PEA_1_T34 and D12335JPEA_1_T36. Table 5847 below describes the starting and ending position of this segment on each transcript.

Table 5847 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P6, D12335_PEA_1_P21 and D12335_PEA_1_P11. This segment can also be found in the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335JPEA_1J?7, D12335_PEA_1_P8 and D12335_PEA_1_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D12335JPEA_l_node__66 according to the present invention is supported by 140 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5848 below describes the starting and ending position of this segment on each transcript.

Table 5848 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1JP1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_1_P16.

Segment cluster D12335_PEA_l_node_67 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T7, D12335_PEA_1_T18, D12335_PEA_l_T30 and D12335_PEA_1_T42. Table 5849 below describes the starting and ending position of this segment on each transcript.

Table 5849 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 5850.

Table 5850 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1 and D12335_PEA_1_P5. This segment can also be found in the following protein(s): D12335_PEA_1_P19, since it is in the coding region for the corresponding transcript. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster D12335JPEA_l_node_5 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T28, D12335_PEA_1_T29 and D12335_PEA_l_T40. Table 5851 below describes the starting and ending position of this segment on each transcript.

Table 5851 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P7 and D12335_PEA_1_P17.

Segment cluster D12335_PEA_l_node_8 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_1_T28 and D12335_PEA_l_T40. Table 5852 below describes the starting and ending position of this segment on each transcript.

Table 5852 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P7. This segment can also be found in the following protein(s): D12335_PEA_1_P17, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_12 according to the present invention is supported by 15 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335JPEA _1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T36, D12335JPEA_1_T38 and D12335_PEA_1_T39. Table 5853 below describes the starting and ending position of this segment on each transcript.

Table 5853 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D 12335JPEAJJPl, D12335_PEAJ_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335_PEA_1_P13, D12335JPEAJ J^>15 and D12335JΕAJ J^>16.

Segment cluster D12335_PEA_l_node_13 according to the present invention can be found in the following transcript(s): D12335JPEAJ _TO, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335JΕAJ_T16, D12335JPEAJ_T17, D12335JPEAJ _T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_l_T30, D12335JPEAJ_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5854 below describes the starting and ending position of this segment on each transcript. Table 5854 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_1 JP20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P1 1, D12335_PEA_1_P12, D12335_PEA_1 JP15 and D12335_PEAJJP16.

Segment cluster D12335JPEA_l_node_14 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335JPEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5855 below describes the starting and ending position of this segment on each transcript. Table 5855 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335_PEA_1_P15 and D12335_PEA_1_P16.

Segment cluster D12335_PEA_l_node_15 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T2, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335JPEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5856 below describes the starting and ending position of this segment on each transcript.

Table 5856 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335 JPEAJ JPl, D12335JPEAJJP20, D12335JPEAJJP5, D12335_PEA_1_P6, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335_PEA_1_P15 and D 12335J⁵EAJJM 6.

Segment cluster D12335_PEA_l_node_16 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T2, D12335_PEA_1_T5, D12335_PEA_1_T7, D12335JPEAJ_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335J^>EA_1_T26, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335JΕAJ_T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5857 below describes the starting and ending position of this segment on each transcript.

Table 5857 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D 12335JPEAJJPl, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P8, D12335JPEAJJP21, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335_PEA_1_P15 and D12335_PEA_1_P16.

Segment cluster D12335_PEA_l_node_18 according to the present invention is supported by 20 libraries. The number of libraries was detennined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA__1_T18, D12335_PEA_1_T22, D12335_PEAJ_T25, D12335_PEA_1_T26, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335JPEA_1_T39. Table 5858 below describes the starting and ending position of this segment on each transcript.

Table 5858 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1JP11, D12335_PEA_1_P12, D12335 PEA 1 P15 and D12335 PEA 1 P16. Segment cluster D12335JPEA_l_node_19 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335JPEA_1_T6, D12335_PEA_1_T7, D12335JPEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335JPEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T36, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5859 below describes the starting and ending position of this segment on each transcript. Table 5859 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335JPEAJJP8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335_PEA_1_P13, D12335_PEA_1_P15 and D12335_PEA_1_P16.

Segment cluster Dl 2335_JPEA_l_node_21 according to the present invention is supported by 140 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335JPEAJ_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T36, D12335_PEA_1_T38 and D12335_PEA_l_T39. Table 5860 below describes the starting and ending position of this segment on each transcript.

Table 5860 - Segment location on transcripts

This segment can be found in the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335JPEAJJP8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335_PEA_1_P13, D12335 PEA 1 P15 and D12335 PEA 1 P16.

Segment cluster D12335_PEA_l_node_23 according to the present invention is supported by 146 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335JPEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T36, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5861 below describes the starting and ending position of this segment on each transcript.

Table 5861 - Segment location on transcripts

This segment can be found in the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335J^>EA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335JPEA_1JP21, D12335_PEA_1_P11, D12335JPEA_1_P12, D12335 PEA_1J^»13, D12335_PEA 1 P15 and D12335 PEA 1 P16.

Segment cluster D12335_PEA_l_node_26 according to the present invention is supported by 137 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_ T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5862 below describes the starting and ending position of this segment on each transcript.

Table 5862 - Segment location on transcripts

This segment can be found in the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335J?EA_1_P11, D12335JPEA_1J^>12, D12335 PEA 1 P15 and D12335 PEA 1 P16.

Segment cluster D12335_PEA_1 jnode_27 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T35, D12335_PEA_1_T38 and D12335_PEA_1_T39. Table 5863 below describes the starting and ending position of this segment on each transcript.

Table 5863 - Segment location on transcripts

This segment can be found in the following protein(s): D12335_PEA_1_P1, D12335JPEAJJP20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P12, D12335 PEA 1 P15 and D12335 PEA 1 P16.

Segment cluster D12335_PEA_l_node_31 according to the present invention is supported by 128 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T32, D12335_PEA_1_T35, D12335_PEA_1_T36 and D12335_PEA_1_T38. Table 5864 below describes the starting and ending position of this segment on each transcript.

Table 5864 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335JPEA 1 P21. This segment can also be found in the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P12, D12335_PEA_1_P13 and D12335JPEA_1_P15, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_37 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in tte following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335JPEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335JPEA_1_T16, D12335_PEA_1_T17, D12335JPEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34 and D12335_PEA_1_T36. Table 5865 below describes the starting and ending position of this segment on each transcript.

Table 5865 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P21. This segment can also be found in the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P11 and D12335_PEA_1_P13, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_38 according to the present invention is supported by 104 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEAJ_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34 and D12335_PEA_1_T36. Table 5866 below describes the starting and ending position of this segment on each transcript.

Table 5866 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335JPEA_1_P6, D12335_PEA_1_P21 and D12335_PEA_l_Pl l. This segment can also be found in the following protein(s): 01233S-PEA-I-Pl₃ D12335_PEA_l_P20, D12335_PEA_1_P7, D12335JPEA_1JP8 and D12335_I>EA_1_P13, since it is in the coding region for the corresponding transcript. Segment cluster D12335_PEA_l_node_40 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEAJ_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335JPEA_1_T22, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T31, D12335JPEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5867 below describes the starting and ending position of this segment on each transcript.

Table 5867 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11 and D12335_PEA_1_P13. This segment can also be found in the following protein(s): D12335_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335JPEA_l_node_41 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335JPEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335JPEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5868 below describes the starting and ending position of this segment on each transcript.

Table 5868 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335JPEA__l_P20, D12335JPEA_1_P6, D12335_PEA_1_P7, D12335JPEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11 and D12335_PEA_1_P13. This segment can also be found in the following protein(s): D12335_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_42 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335JPEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5869 below describes the starting and ending position of this segment on each transcript.

Table 5869 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335JPEAJUP21, D12335_PEA_1_P11 and D12335_PEA_1_P13. This segment can also be found in the following protein(s): D12335_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335JPEA_l_node_43 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1,

D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T31, D12335_PEA _1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5870 below describes the starting and ending position of this segment on each transcript.

Table 5870 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335JPEA 1JP21, D 12335 JPEAJUP H and D12335_PEA_1_P13. This segment can also be found in the following protein(s): D12335_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_44 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1,

D12335_PEA_1_T2, D12335JPEAJMT3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEAJ_T7, D12335_PEA_1_T16, D12335JPEAJ_T17, D12335_PEA_1_T18, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5871 below describes the starting and ending position of this segment on each transcript.

Table 5871 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335JPEA_1_P21, D12335_PEA_1_P11 and D12335_PEA_1_P13. This segment can also be found in the following protein(s): D12335_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_45 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1,

D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5872 below describes the starting and ending position of this segment on each transcript.

Table 5872 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335JPEAJUP1, D12335_PEA_l_P20, D12335JPEA_1JP6, D12335JPEAJJP7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11 and D12335_PEA_1_P13. This segment can also be found in the following protein(s): D12335_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_46 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1,

D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335JPEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5873 below describes the starting and ending position of this segment on each transcript.

Table 5873 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1JP8, D12335_PEA_1_P21, D12335_PEA_1_P11 and D12335_PEA_1_P13. This segment can also be found in the following protein(s): D12335_PEA_1_P5 and D12335_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_47 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335JPEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5874 below describes the starting and ending position of this segment on each transcript.

Table 5874 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335JPEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11 and D12335_PEA_1_P13. This segment can also be found in the following protein(s): D12335_PEA_1_P5 and D12335JPEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_48 according to the present invention is supported by 133 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335JPEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31,

D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5875 below describes the starting and ending position of this segment on each transcript.

Table 5875 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335JPEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11 and D12335_PEA_1JP13. This segment can also be found in the following protein(s): D12335_PEA_1_P5 and D12335_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_49 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335JPEA_ l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5876 below describes the starting and ending position of this segment on each transcript. Table 5876 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335JPEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335JPEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_1_P16. This segment can also be found in the following protein(s): D12335_PEA_1_P5, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_50 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335JPEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T25, D12335JPEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335 PEA 1 T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5877 below describes the starting and ending position of this segment on each transcript.

Table 5877 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1JP1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_1_P16. This segment can also be found in the following protein(s): D12335_PEA_1_P5, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_ l_node_51 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1₅ D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335JPEA_1_T25, D12335JPEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA _l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335JPEA_1_T39. Table 5878 below describes the starting and ending position of this segment on each transcript.

Table 5878 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_1_P16. This segment can also be found in the following protein(s): D12335_PEA_1_P5, since it is in the coding region for the corresponding transcript.

Segment cluster D12335_PEA_l_node_52 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335JPEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5879 below describes the starting and ending position of this segment on each transcript.

Table 5879 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335JPEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_1_P16.

Segment cluster D12335_PEA_l_node_53 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335JPEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5880 below describes the starting and ending position of this segment on each transcript.

Table 5880 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335JPEAJJP7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_l_P16.

Segment cluster D12335_PEA_l_node_54 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5881 below describes the starting and ending position of this segment on each transcript.

Table 5881 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA 1 PI l, D12335_PEA 1 P13 and D12335 PEA 1 P16.

Segment cluster D12335_PEA_l_node_55 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5882 below describes the starting and ending position of this segment on each transcript.

Table 5882 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335JPEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEAJ_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_l_P16.

Segment cluster D12335_PEA_l_node_56 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5883 below describes the starting and ending position of this segment on each transcript.

Table 5883 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_l_P16.

Segment cluster D12335_PEA_l_node_57 according to the present invention can be found in the following transcript(s): D12335_PEA_l_ T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335JPEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_1_T3O, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335JPEA_1_T39. Table 5884 below describes the starting and ending position of this segment on each transcript.

Table 5884 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1JP1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_l_Pl l, D12335_PEA_l_P13 and D12335_PEA 1 P16.

Segment cluster D12335_PEA_l_node_58 according to the present invention is supported by 153 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T25, D12335_PEA_1 _T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30,

D12335_PEA_1_T31, D12335_PEA_1_T32, D12335JPEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5885 below describes the starting and ending position of this segment on each transcript.

Table 5885 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_l_P16.

Segment cluster D12335_PEA_l_node_59 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335JPEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335JPEA_1_T31, D12335JPEAJ_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5886 below describes the starting and ending position of this segment on each transcript.

Table 5886 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1JP1, D12335JPEA_l_P20, D12335JPEAJJP5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_l_P16.

Segment cluster D12335_PEA_ l_node_60 according to the present invention is supported by 149 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5887 below describes the starting and ending position of this segment on each transcript.

Table 5887 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335JPEA_1_P6, D12335_PEA_1J?7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_l_P16.

Segment cluster D12335JPEA_l_node_61 according to the present invention can be found in the following transcript(s): D12335_PEA_l__T0, D12335JPEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5888 below describes the starting and ending position of this segment on each transcript.

Table 5888 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335JPEAJJP1, D12335_PEA_l_P20, D12335JPEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_1_P16.

Segment cluster D12335_PEA_l_node__62 according to the present invention is supported by 145 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335_PEA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_JPEA_l_T30,

D12335_PEA_1_T31, D12335_PEAJ_T32, D12335_PEA_1_T34, D12335_PEA_1 _T36 and D12335JPEA_1_T39. Table 5889 below describes the starting and ending position of this segment on each transcript.

Table 5889 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335_PEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEA_1_P13 and D12335_PEA_l_P16.

Segment cluster D12335_PEA_l_node_63 according to the present invention is supported by 143 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): D12335J?EA_l_T0, D12335_PEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335JPEA_1_T6, D12335J^>EA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335_PEA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1_T39. Table 5890 below describes the starting and ending position of this segment on each transcript.

Table 5890 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_l_P20, D12335_PEA_1_P5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335JPEA_1_P8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335_PEAJ_P13 and D12335_PEA_l_P16.

Segment cluster D12335_PEA_l_node_65 according to the present invention can be found in the following transcript(s): D12335_PEA_l_T0, D12335JPEA_1_T1, D12335_PEA_1_T2, D12335_PEA_1_T3, D12335_PEA_1_T4, D12335_PEA_1_T5, D12335_PEA_1_T6, D12335_PEA_1_T7, D12335_PEA_1_T16, D12335_PEA_1_T17, D12335_PEA_1_T18, D12335_PEA_1_T22, D12335_PEA_1 _T25, D12335_PEA_1_T26, D12335_PEA_1_T28, D12335_PEA_1_T29, D12335_PEA_l_T30, D12335J^>EA_1_T31, D12335_PEA_1_T32, D12335_PEA_1_T34, D12335_PEA_1_T36 and D12335_PEA_1__T39. Table 5891 below describes the starting and ending position of this segment on each transcript.

Table 5891 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): D12335_PEA_1_P1, D12335_PEA_1 JP20, D12335JPEAJJP5, D12335_PEA_1_P6, D12335_PEA_1_P7, D12335JPEAJ JP8, D12335_PEA_1_P21, D12335_PEA_1_P11, D12335JPEAJJP13 and D12335_PEA_l_P16.

DESCRIPTION FOR CLUSTER HUMGGTX Cluster HUMGGTX features 5 transcript(s) and 31 segment(s) of interest, the names for which are given in Tables 5892 and 5893, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5894.

Table 5892 - Transcripts of interest

Transcript Name

HUMGGTX PEA 1 T7

HUMGGTX PEA 1 T8

HUMGGTX PEA 1 T17

HUMGGTX PEA 1 T50

HUMGGTX PEA 1 T52

Table 5893 - Segments of interest

Segment Name •

HUMGGTX PEA 1 node 2

HUMGGTX PEA 1 node 3

HUMGGTX PEA 1 node 7

HUMGGTX PEA 1 node 8

HUMGGTX PEA 1 node 17

HUMGGTX PEA 1 node 18

HUMGGTX PEA 1 node 19

HUMGGTX PEA 1 node 28

HUMGGTX PEA 1 node 31

HUMGGTX PEA 1 node 37

HUMGGTX PEA 1 node 40

HUMGGTX PEA 1 node 45

HUMGGTX PEA 1 node 48

HUMGGTX PEA 1 node 54

HUMGGTX PEA 1 node 56

HUMGGTX PEA 1 node 64

HUMGGTX PEA 1 node 65

HUMGGTX PEA 1 node 16

HUMGGTX PEA 1 node 20

HUMGGTX PEA 1 node 22

HUMGGTX PEA 1 node 23

HUMGGTX PEA 1 node 24

HUMGGTX PEA 1 node 25

HUMGGTX PEA 1 node 26 HUMGGTX PEA 1 node 33

HUMGGTX PEA 1 node 38

HUMGGTX PEA 1 node 53

HUMGGTX PEA 1 node 58

HUMGGTX PEA 1 node 59

HUMGGTX PEA 1 node 61

HUMGGTX PEA 1 node 62

Table 5894 - Proteins of interest

These sequences are variants of the known protein Gamma-glutamyltranspeptidase 1 precursor (SwissProt accession identifier GGT1_HUMAN; known also according to the synonyms EC 2.3.2.2; Gamma- glutamyltransferase 1; CD224 antigen), referred to herein as the previously known protein.

Protein Gamma-glutamyltranspeptidase 1 precursor is known or believed to have the following function(s): Initiates extracellular gluthatione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys- GIy and gamma glutamate. Isoform 3 seems to be inactive. The sequence for protein Gamma- glutamyltranspeptidase 1 precursor is given at the end of the application, as "Gamma- glutamyltranspeptidase 1 precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5895.

Table 5895 - Amino acid mutations for Known Protein

Protein Gamma-glutamyltranspeptidase 1 precursor localization is believed to be Type II membrane protein.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: amino acid metabolism; glutathione biosynthesis, which are annotation(s) related to Biological Process; gamma-glutamyl transferase; acyltransferase; transferase, which are annotation(s) related to Molecular Function; and membrane fraction; membrane; integral membrane protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>. Cluster HUMGGTX can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 141 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 141 and Table 5896. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: a mixture of malignant tumors from different tissues.

Table 5896 - Normal tissue distribution

Table 5897 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMGGTX features 31 segment(s), which were listed in Table 5893 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMGGTX_PEA_l_node_2 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1 _T50. Table 5898 below describes the starting and ending position of this segment on each transcript.

Table 5898 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P21.

Segment cluster HUMGGTX_PEA_l_node_3 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HUMGGTX_PEA_l_T50. Table 5899 below describes the starting and ending position of this segment on each transcript.

Table 5899 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P21.

Segment cluster HUMGGTXJPEA_l_node_7 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8, HUMGGTX_PEA_1_T17 and HUMGGTXJPEA_1_T52. Table 5900 below describes the starting and ending position of this segment on each transcript.

Table 5900 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMGGTX PEA 1JP26 and HUMGGTXJPEA_lJPl.

Segment cluster HUMGGTX_PEA_l_node_8 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T52. Table 5901 below describes the starting and ending position of this segment on each transcript.

Table 5901 - Segment location on transcripts

This segment can be found in tie following transcript(s), which do not code for proteins: HUMGGTX PEA 1 T52. Segment cluster HUMGGTX_PEA_l_node_17 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7. Table 5902 below describes the starting and ending position of this segment on each transcript.

Table 5902 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26.

Segment cluster HUMGGTX_PEA_l_node_18 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1 _T7. Table 5903 below describes the starting and ending position of this segment on each transcript.

Table 5903 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26.

Segment cluster HUMGGTX_PEA_ l_node_19 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTXJPEA_1_T7. Table 5904 below describes the starting and ending position of this segment on each transcript.

Table 5904 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26.

Segment cluster HUMGGTX_JPEA_l_node_28 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX JPEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5905 below describes the starting and ending position of this segment on each transcript. Table 5905 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl.

Segment cluster HUMGGTX_PEA_l_node_31 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5906 below describes the starting and ending position of this segment on each transcript. Table 5906 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1 JP26 and HUMGGTX PEA 1 Pl. Segment cluster HUMGGTX_PEA_l_node_37 according to the present invention is supported by 53 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX JPEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5907 below describes the starting and ending position of this segment on each transcript.

Table 5907 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTXJPEA_1_P26 and HUMGGTX_PEA_1_P 1.

Segment cluster HUMGGTX_PEA_l_node_40 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5908 below describes the starting and ending position of this segment on each transcript.

Table 5908 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl.

Segment cluster HUMGGTX_PEA_l_node_45 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1__T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5909 below describes the starting and ending position of this segment on each transcript.

Table 5909 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX_PEA_1_P 1.

Segment cluster HUMGGTX_PEA_l_node_48 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5910 below describes the starting and ending position of this segment on each transcript.

Table 5910 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl.

Segment cluster HUMGGTX_PEA_l_node_54 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5911 below describes the starting and ending position of this segment on each transcript. Table 5911 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl .

Segment cluster HUMGGTX_PEA_l_node_56 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTXJPEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5912 below describes the starting and ending position of this segment on each transcript.

Table 5912 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX_PEA_1_P1.

Segment cluster HUMGGTX_PEA_l_node_64 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5913 below describes the starting and ending position of this segment on each transcript.

Table 5913 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTXJPEA_1_P26 and HUMGGTXJPEA J_P 1.

Segment cluster HUMGGTX_PEA_l_node_65 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX JPEA_1_T17. Table 5914 below describes the starting and ending position of this segment on each transcript. Table 5914 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26. This segment can also be found in the following protein(s): HUMGGTX_PEA_1JP1, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMGGTXJPEA_l_node_16 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1 _T17. Table 5915 below describes the starting and ending position of this segment on each transcript.

Table 5915 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX_PEA_1_P1.

Segment cluster HUMGGTX_PEA_l_node_20 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1 _T8 and HUMGGTX_PEA_1_T17. Table 5916 below describes the starting and ending position of this segment on each transcript.

Table 5916 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX_PEA_l_Pl.

Segment cluster HUMGGTXJPEA_l_node_22 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTXJPEA_ 1_T7 and

HUMGGTX_PEA_1_T8. Table 5917 below describes the starting and ending position of this segment on each transcript.

Table 5917 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1 JP26.

Segment cluster HUMGGTX_PEA_l_node_23 according to the present invention can be found in the following transcript(s): HUMGGTX_PEA_1_T7 and HUMGGTX_PEA_1_T8. Table 5918 below describes the starting and ending position of this segment on each transcript.

Table 5918 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26.

Segment cluster HUMGGTX_PEA_l_node_24 according to the present invention is supported by 37 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7,

HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5919 below describes the starting and ending position of this segment on each transcript.

Table 5919 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX_PEA_1_P1. Segment cluster HUMGGTXJPEA__l_node_25 according to the present invention is supported by 40 libraries. The number of libraπes was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5920 below describes the starting and ending position of this segment on each transcript.

Table 5920 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX_PEA_1_P1.

Segment cluster HUMGGTX_PEA_l_node_26 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1__T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5921 below describes the starting and ending position of this segment on each transcript.

Table 5921 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMGGTX_PEA_ 1JP26 and HUMGGTX_PEA_1_P1.

Segment cluster HUMGGTX_PEA_l_node_33 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTXJPEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5922 below describes the starting and ending position of this segment on each transcript.

Table 5922 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl.

Segment cluster HUMGGTXJPEA_l_node_38 according to the present invention can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX JPEA_1_T17. Table 5923 below describes the starting and ending position of this segment on each transcript.

Table 5923 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl.

Segment cluster HUMGGTX_PEA_l_node_53 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7,

HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5924 below describes the starting and ending position of this segment on each transcript.

Table 5924 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX__PEA_1_P26 and HUMGGTX_PE A_l _P 1.

Segment cluster HUMGGTX_PEA_l_node_58 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX JPEA 1_T8 and HUMGGTX_PEA__1_T17. Table 5925 below describes the starting and ending position of this segment on each transcript.

Table 5925 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl.

Segment cluster HUMGGTX_PEA_l_node_59 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5926 below describes the starting and ending position of this segment on each transcript. Table 5926 - Segment location on transcripts

I HUMGGTX PEA 1 T 17 I 2078 I 2163 I

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX__PEA__1_P1.

Segment cluster HUMGGTXJPEA_l_node_61 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1 _T7, HUMGGTX_PEA_1_T8 and HUMGGTXJPEA_1_T17. Table 5927 below describes the starting and ending position of this segment on each transcript.

Table 5927 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl.

Segment cluster HUMGGTX_PEA_l_node_62 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMGGTX_PEA_1_T7, HUMGGTX_PEA_1_T8 and HUMGGTX_PEA_1_T17. Table 5928 below describes the starting and ending position of this segment on each transcript. Table 5928 - Segment location on transcripts

This segment can be found in the following protein(s): HUMGGTX_PEA_1_P26 and HUMGGTX PEA 1 Pl.

DESCRIPTION FOR CLUSTER HUMVWF

Cluster HUMVWF features 12 transcript(s) and 82 segment(s) of interest, the names for which are given in Tables 5929 and 5930, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 5931.

Table 5929 - Transcripts of interest

Transcript Name -

HUMVWF PEA 1 Tl

HUMVWF PEA 1 T5

HUMVWF PEA 1 T25

HUMVWF PEA 1 T27

HUMVWF PEA 1 T28

HUMVWF PEA 1 T32

HUMVWF PEA 1 T34

HUMVWF PEA 1 T37

HUMVWF PEA 1 T38

HUMVWF PEA 1 T45

HUMVWF PEA 1 T46

HUMVWF PEA 1 T49

Table 5930 - Segments of interest

Segment Name

HUMVWF PEA 1 node 0

HUMVWF PEA 1 node 7

HUMVWF PEA 1 node 8

HUMVWF PEA 1 node 16

HUMVWF PEA 1 node 20

HUMVWF PEA 1 node 22

HUMVWF PEA 1 node 24

HUMVWF PEA 1 node 30

HUMVWF PEA 1 node 32

HUMVWF PEA 1 node 37 HUMVWF PEA 1 node 38

HUMVWF PEA 1 node 39

HUMVWF PEA 1 node 41

HUMVWF PEA 1 node 43

HUMVWF PEA 1 node 47

HUMVWF PEA 1 node 51

HUMVWF PEA 1 node 53

HUMVWF PEA 1 node 55

HUMVWF PEA 1 node 57

HUMVWF_ _PEA_ _1_ node_ 60

HUMVWF PEA 1 node 61

HUMVWF PEA 1 node 62

HUMVWF PEA 1 node 63

HUMVWF PEA 1 node 65

HUMVWF PEA 1 node 67

HUMVWF PEA 1 node 69

HUMVWF PEA 1 node 71

HUMVWF PEA 1 node 75

HUMVWF PEA 1 node 81

HUMVWF PEA 1 node 93

HUMVWF PEA 1 node 95

HUMVWF PEA 1 node 98

HUMVWF PEA 1 node 100

HUMVWF PEA 1 node 110

HUMVWF PEA 1 node 112

HUMVWF_ PEA 1 node 118

HUMVWF PEA 1 node 129

HUMVWF PEA 1 node 130

HUMVWF PEA 1 node 131

HUMVWF PEA 1 node 133

HUMVWF PEA 1 node 139

HUMVWF PEA 1 node 140

HUMVWF PEA 1 node 141

HUMVWF PEA 1 node 1

HUMVWF PEA 1 node 6

HUMVWF PEA 1 node 10

HUMVWF PEA 1 node 11

HUMVWF PEA 1 node 13

HUMVWF PEA 1 node 14

HUMVWF PEA 1 node 18

HUMVWF PEA 1 node 19

HUMVWF PEA 1 node 26

HUMVWF PEA 1 node 28

HUMVWF PEA 1 node 34 HUMVWF PEA 1 node 45

HUMVWF PEA 1 node 49

HUMVWF PEA 1 node 59

HUMVWF PEA 1 node 73

HUMVWF PEA 1 node 77

HUMVWF PEA 1 node 78

HUMVWF PEA 1 node 79

HUMVWF PEA 1 node 83

HUMVWF PEA 1 node 86

HUMVWF PEA 1 node 87

HUMVWF PEA 1 node 88

HUMVWF PEA 1 node 92

HUMVWF PEA 1 node 96

HUMVWF PEA 1 node 104

HUMVWF PEA 1 node 106

HUMVWF PEA 1 node 108

HUMVWF PEA 1 node 114

HUMVWF PEA 1 node 117

HUMVWF PEA 1 node 119

HUMVWF PEA 1 node 122

HUMVWF PEA 1 node 125

HUMVWF PEA 1 node 127

HUMVWF PEA 1 node 132

HUMVWF PEA 1 node 134

HUMVWF PEA 1 node 135

HUMVWF_ JPEA _1 _node 136

HUMVWF PEA 1 node 137

HUMVWF PEA 1 node 138

Table 5931 - Proteins of interest

These sequences are variants of the known protein Von Willebrand factor precursor (SwissProt accession identifier VWF_HUMAN; known also according to the synonyms vWF), referred to herein as the previously known protein.

Protein Von Willebrand factor precursor is known or believed to have the following function(s): Important in the maintenance of homeostasis, it participates in platelet- vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The sequence for protein Von Willebrand factor precursor is given at the end of the application, as "Von Willebrand factor precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 5932.

Table 5932 - Amino acid mutations for Known Protein

The previously known protein also has the following indication(s) and/or potential therapeutic use(s): von Willebrand's disease. It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Factor VIII modulator. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Haemostatic; Antithrombotic .

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell adhesion; blood coagulation, which are annotation(s) related to Biological Process; protein binding, which are annotation(s) related to Molecular Function; and extracellular matrix; extracellular space, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HUMVWF can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 142 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 142 and Table 5933. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: kidney malignant tumors and pancreas carcinoma.

Table 5933 - Normal tissue distribution

Table 5934 - P values and ratios for expression in cancerous tissue

As noted above, cluster HUMVWF features 82 segment(s), which were listed in Table 5930 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HUMVWF_PEA_l_node_0 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_ 1_T28, HUMVWF JPEA_1_T32, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEAJ_T49. Table 5935 below describes the starting and ending position of this segment on each transcript.

Table 5935 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWFJPEAJJP1, HUMVWF_PEA_1JP2, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21, HUMVWF_PEA_ 1JP25, HUMVWF_PEA_1_P32, HUMVWF_PEA_l_P30 and HUMVWF_PEA_1JP33.

Segment cluster HUMVWF_PEA_l_node_7 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1 and HUMVWF_PEA_1_T37. Table 5936 below describes the starting and ending position of this segment on each transcript.

Table 5936 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P1 and HUMVWF_PEA_1_P2.

Segment cluster HUMVWF_PEA_l_node_8 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T37 and HUMVWF_PEA_1_T38. Table 5937 below describes the starting and ending position of this segment on each transcript.

Table 5937 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P1 and HUMVWF_PEA_1JP2.

Segment cluster HUMVWF_PEA_l_node_16 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T32, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5938 below describes the starting and ending position of this segment on each transcript. Table 5938 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P19, HUMVWFJPEA_1_P21, HUMVWF_PEA_1_P32, HUMVWF_PEA_l_P30 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_20 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T32. Table 5939 below describes the starting and ending position of this segment on each transcript.

Table 5939 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P25.

Segment cluster HUMVWF_PEA_l_node_22 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWFJPEA_1_T1, HUMVWF_PEA_1_T5, HUMVWFJPEAJ _T25, HUMVWFJPEA_1_T28, HUMVWF JPEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5940 below describes the starting and ending position of this segment on each transcript.

Table 5940 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1JP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1JP33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_24 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_ 1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEAJ_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5941 below describes the starting and ending position of this segment on each transcript.

Table 5941 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_30 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWFJPEA_1_T49. Table 5942 below describes the starting and ending position of this segment on each transcript.

Table 5942 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcπpt(s) that are related to the following protein(s): HUMVWFJPEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWFJPEA 1 P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_32 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5943 below describes the starting and ending position of this segment on each transcript.

Table 5943 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWFJPEAJ JPl, HUMVWFJPEAJ JP 19, HUMVWFJΕAJ J^>21 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_37 according to the present invention is supported by 3 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMVWFJΕAJ _T34. Table 5944 below describes the starting and ending position of this segment on each transcript.

Table 5944 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWFJPEAJ JP27.

Segment cluster HUMVWFJPEAJ _node_38 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF JPE A J_T5, HUMVWF JPEAJ _T25, HUMVWF JPEAJ _T28, HUMVWF JΕAJ_T34, HUMVWFJΕAJ _T37, HUMVWF JPEA J_T38, HUMVWFJPEAJ _T45, HUMVWFJPEAJ _T46 and HUMVWFJPEAJ _T49. Table 5945 below describes the starting and ending position of this segment on each transcript.

Table 5945 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWFJPEA_1JP27, HUMVWF_PEA_1JP32 and HUMVWFJPEAJ JP33. This segment can also be found in the following protein(s): HUMVWFJPEAJJPl, HUMVWFJPEA_1_P19, HUMVWFJPEAJJP21 and HUMVWF_PEA_1JP3O, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_39 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_ 1 JT28 and HUMVWFJPEA_1_T34. Table 5946 belcw describes the starting and ending position of this segment on each transcript. Table 5946 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P27. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P21, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_41 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5947 below describes the starting and ending position of this segment on each transcript.

Table 5947 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1JP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P19 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_43 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEAJ_T37,

HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWFJPEA_1_T46 and HUMVWF_PEA_1_T49. Table 5948 below describes the starting and ending position of this segment on each transcript.

Table 5948 - Segment location on transcripts

005/002438

3338

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWFJ^>EA_1JP19 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_47 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF PEA I TI, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5949 below describes the starting and ending position of this segment on each transcript.

Table 5949 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF JPEA_1J^>32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1 JPl, HUMVWF_PEA_1_P19 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_51 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF JPEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5950 below describes the starting and ending position of this segment on each transcript.

Table 5950 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P19 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_53 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWFJPEAJ _T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF J?EA_1_T46 and HUMVWF_PEA_1_T49. Table 5951 below describes the starting and ending position of this segment on each transcript.

Table 5951 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWFJ?EA_1JP19 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_55 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5952 below describes the starting and ending position of this segment on each transcript.

Table 5952 - Segment location on transcripts

5 002438

3341

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF JPEA_1JP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF JΕAJ JPl, HUMVWF JPEA_1JP19 and HUMVWF JPEAJ J?30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_57 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF JPEA J _T5, HUMVWF JPEA J _T25, HUMVWF JPEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5953 below describes the starting and ending position of this segment on each transcript.

Table 5953 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1 , HUMVWF_PEA_1_P19 and HUMVWFJPEAJJP30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_60 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T5 and

HUMVWF_PEA_1_T25. Table 5954 below describes the starting and ending position of this segment on each transcript.

Table 5954 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1 JP2. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_61 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T5 and HUMVWF_PEA_1_T25. Table 5955 below describes the starting and ending position of this segment on each transcript.

Table 5955 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2 and HUMVWF_PEA_1_P19.

Segment cluster HUMVWF_PEA_l_node_62 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37, HUMVWFJPEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5956 below describes the starting and ending position of this segment on each transcript.

Table 5956 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWFJPEA_1_P2, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWFJPEA.JJP1 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript. Segment cluster HlJMVWF JPEA J _node_63 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF JPEA J _T25. Table 5957 below describes the starting and ending position of this segment on each transcript.

Table 5957 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P19.

Segment cluster HUMVWF_PEA_l_node_65 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF JPEAJ _T37, HUMVWF JΕAJ_T38, HUMVWFJ^>EA_1_T45, HUMVWFJΕAJ _T46 and HUMVWF JPEA J _T49. Table 5958 below describes the starting and ending position of this segment on each transcript.

Table 5958 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF J^>EA J JP2, HUMVWF_PEA_1_P32 and

HUMVWFJPEAJ JP33. This segment can also be found in the following protein(s): HUMVWF_PEA_1 JPl and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_67 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1 _Tl , HUMVWF_PEA_1_T5, HUMVWF JPEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF JPEAJ _T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1 _T49. Table 5959 below describes the starting and ending position of this segment on each transcript. Table 5959 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF JPEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s):

HUMVWF_PEA_1_P1 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_69 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T5, HIJMVWF_PEA_1 _T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5960 below describes the starting and ending position of this segment on each transcript. Table 5960 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1JP2, HUMVWF_PEA_1_P32 and

HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_71 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1__T1, HUMVWFJPEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5961 below describes the starting and ending position of this segment on each transcript. Table 5961 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P30. This segment can also be found in the following protein(s): HUMV WF_PEA_ IJPl, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33, since it is in the coding region for the corresponding transcπpt.

Segment cluster HUMVWF_PEA_l_node_75 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5962 below describes the starting and ending position of this segment on each transcript.

Table 5962 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P30. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_81 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5963 below describes the starting and ending position of this segment on each transcript. Table 5963 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1 JP33.

Segment cluster HUMVWF_PEA_l_node_93 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWFJPEAJ _T49. Table 5964 below describes the starting and ending position of this segment on each transcript.

Table 5964 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_95 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWFJPEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5965 below describes the starting and ending position of this segment on each transcript.

Table 5965 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_98 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5966 below describes the starting and ending position of this segment on each transcript. Table 5966 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. 05 002438

3350

Segment cluster HUMVWF_PEA_l_node__100 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWFJPEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5967 below describes the starting and ending position of this segment on each transcript.

Table 5967 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF JPEA_1JP32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWFJPEA_ l_node_ l 10 according to the present invention is supported by 94 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38,

HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5968 below describes the starting and ending position of this segment on each transcript.

Table 5968 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_l 12 according to the present invention is supported by 91 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF JPEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5969 below describes the starting and ending position of this segment on each transcript.

Table 5969 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_l 18 according to the present invention is supported by 140 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5970 below describes the starting and ending position of this segment on each transcript

Table 5970 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_129 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWFJPEA_1_T27. Table 5971 below describes the starting and ending position of this segment on each transcript.

Table 5971 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWFJPEAJJP20.

Segment cluster HUMVWF_PEA_l_node_130 according to the present invention is supported by 194 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF J?EA_1_T5, HUMVWF_PEA_1_T27, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5972 below describes the starting and ending position of this segment on each transcript. Table 5972 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P20 and HUMVWFJPEA_1JP33. This segment can also be found in the following protein(s): HUMVWF J^»EA_1_P1, HUMVWF_PEA_1_P2 and HUMVWF_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_131 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T27 and

HUMVWF_PEA_1_T45. Table 5973 below describes the starting and ending position of this segment on each transcript.

Table 5973 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWFJPEA_l_P20. This segment can also be found in the following protein(s): HUMVWFJPEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_133 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T27. Table 5974 below describes the starting and ending position of this segment on each transcript. Table 5974 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P20.

Segment cluster HUMVWF_PEA_l__node_139 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T27. Table 5975 below describes the starting and ending position of this segment on each transcript.

Table 5975 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_l_P20.

Segment cluster HUMVWF_PEA_l_node_140 according to the present invention is supported by 195 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF JPEA_1_T27, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5976 below describes the starting and ending position of this segment on each transcript.

Table 5976 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1 , HUMVWFJPEAJJP2 and HUMVWF_PEA_1 JP20, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_141 according to the present invention is supported by 172 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1 , HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T27, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5977 below describes the starting and ending position of this segment on each transcript.

Table 5977 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P32 and HUMVWF__PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2 and HUMVWF_PEA_l_P20, since it is in the coding region for the corresponding transcript. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HUMVWF_PEA_l_node_l according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWFJPEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T32, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5978 below describes the starting and ending position of this segment on each transcript.

Table 5978 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWFJPEAJJP19, HUMVWF_PEA_1_P21, HUMVWF_PEA_1_P32, HUMVWF_PEA_l_P30 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript. Segment cluster HUMVWF_PEA_l_node_6 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWFJPEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T32, HUMVWFJPEA_1_T37, HUMVWF JPEA_1_T38, HUMVWF JPEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5979 below describes the starting and ending position of this segment on each transcript.

Table 5979 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21, HUMVWF_PEA_1_P32, HUMVWF_PEA_lJP30 and HUMVWFJPEAJJP33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_10 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF JPEA_1_T28, HUMVWF_PEA_1_T32, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5980 below describes the starting and ending position of this segment on each transcript.

Table 5980 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWFJPEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21, HUMVWF_PEA_1_P32, HUMVWF_PEA_l_P30 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_l 1 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T32, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5981 below describes the starting and ending position of this segment on each transcript. Table 5981 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWFJPEAJ JPl, HUMVWF PEAJJP2, HUMVWF_PEA_1_P19, HUMVWFJ?EA_1J?21, HUMVWF JPEAJ JP32, HUMVWF_PEA_l_P30 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_13 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HlJMVWF JPEA_1_T28, HUMVWF_PEA_1_T32, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5982 below describes the starting and ending position of this segment on each transcript.

Table 5982 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1JP1, HUMVWFJPEA _1_P2, HUMVWFJPEA_1JP19, HUMVWF_PEA_1_P21, HUMVWF_PEA_1_P32, HUMVWFJ?EA_l_P30 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_14 according to the present invention can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEAJ_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T32, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWFJPEAJ_T45, HUMVWFJPEA_1_T46 and HUMVWF_PEA_1_T49. Table 5983 below describes the starting and ending position of this segment on each transcript.

Table 5983 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1__P19, HUMVWFJPEA_1_P21, HUMVWF_PEA_1_P32, HUMVWF JPEAJ JP30 and HUMVWFJPEAJJP33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_18 according to the present invention is supported by 8 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF JPEAJ_T28, HUMVWF_PEA_1_T32, HUMVWFJPEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5984 below describes the starting and ending position of this segment on each transcript.

Table 5984 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWFJPEAJJPl, HUMVWF_PEA_1_P2, HUMVWF JPEA_1_P19, HUMVWF_PEA_1_P21, HUMVWF_PEA_1_P32, HUMVWFJPEA_l_P30 and HUMVWF_PEA_1JP33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript. Segment cluster HUMVWF_PEA_l_node_19 according to the present invention can be found in the following transcript(s): HUMVWFJPEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF J^>EA_1_T32, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF JPEAJ_T46 and HUMVWF_PEA_1_T49. Table 5985 below describes the starting and ending position of this segment on each transcript.

Table 5985 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P1, HUMVWFJPEA_1_P2, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21, HUMVWF_PEA_1_P32, HUMVWF_PEA_l_P30 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P25, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_26 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWFJPEA_1_T46 and HUMVWF_PEA_1_T49. Table 5986 below describes the starting and ending position of this segment on each transcript.

Table 5986 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of trans cript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWFJPEAJJP1, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21 and HUMVWF_PEA_1 JP30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_28 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1__T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5987 below describes the starting and ending position of this segment on each transcript.

Table 5987 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWFJPEAJJP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1JP1, HUMVWF_PEA_1_P19, HUMVWF_PEA_1_P21 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_34 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1__T1, HUMVWF_PEA_1_T5, HUMVWFJPEA_1_T25, HUMVWF_PEA_1_T28, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5988 below describes the starting and ending position of this segment on each transcript.

Table 5988 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWFJPEA_1 JP32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P19, HUMVWF_PEAJ_P21 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_45 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5989 below describes the starting and ending position of this segment on each transcript. Table 5989 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be fcund in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF J^>EA_1_P19 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript. Segment cluster HUMVWF_PEA_l_node_49 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWFJPEA_1_T1, HUMVWFJPEAJ_T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5990 below describes the starting and ending position of this segment on each transcript.

Table 5990 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWFJPEAJ J^>1, HUMVWF_PEA_1_P19 and HUMVWFJPEA_l__P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_59 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1 _T5, HUMVWF_PEA_1_T25, HUMVWF_PEA_1_T37,

HUMVWF_PEA_1_T38, HUMVWF J^>EA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5991 below describes the starting and ending position of this segment on each transcript. Table 5991 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1 JP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P19 and HUMVWF_PEA_l_P30, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_73 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWFJPEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5992 below describes the starting and ending position of this segment on each transcript.

Table 5992 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P30. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1JP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_77 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF JPEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_ 1_T38, HUMVWF_PEA_1_T45, HUMVWF_PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5993 below describes the starting and ending position of this segment on each transcript.

Table 5993 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P30. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWFJPEA_l_node_78 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1__T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45, HUMVWF__PEA_1_T46 and HUMVWF_PEA_1_T49. Table 5994 below describes the starting and ending position of this segment on each transcript.

Table 5994 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P30. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWFJPEA_l_node_79 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T46. Table 5995 below describes the starting and ending position of this segment on each transcript.

Table 5995 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P30.

Segment cluster HUMVWF_PEA_l_node_83 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWFJPE A_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5996 below describes the starting and ending position of this segment on each transcript.

Table 5996 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1 JP2, HUMVWF JPEA_1_P32 and HUMVWFJPEA_1 JP33.

Segment cluster HUMVWF_PEA_l_node_86 according to the present invention can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5997 below describes the starting and ending position of this segment on each transcript.

Table 5997 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1JP1, HUMVWFJPEAJ J^>2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. Segment cluster HUMVWF_PEA_l_node_87 according to the present invention is supported by 34 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF JPEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5998 below describes the starting and ending position of this segment on each transcript.

Table 5998 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_88 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38,

HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 5999 below describes the starting and ending position of this segment on each transcript.

Table 5999 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF__PEA__1__P1, HUMVWF_PEA_1_P2, HUMVWFJPEAJ JP32 and HUMVWF JPEA_1JP33.

Segment cluster HUMVWF_PEA_l_node_92 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF JPEA_1 _Tl, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF JPEA_1_T49. Table 6000 below describes the starting and ending position of this segment on each transcript. Table 6000 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWFJPE A_l JPl, HUMVWF_PEA_1 JP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1 JP33.

Segment cluster HUMVWF_PEA_l_node_96 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_ljri, HUMVWF JPEAJ_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6001 below describes the starting and ending position of this segment on each transcript.

Table 6001 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_104 according to the present invention is supported by 72 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6002 below describes the starting and ending position of this segment on each transcript.

Table 6002 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1 JP33.

Segment cluster HUMVWF_PEA_l_node_106 according to the present invention is supported by 75 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6003 below describes the starting and ending position of this segment on each transcript.

Table 6003 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWFJPEAJJP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_1 jtiode_108 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEAJ_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6004 below describes the starting and ending position of this segment on each transcript.

Table 6004 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_l 14 according to the present invention is supported by 103 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWFJPEA_1_T49. Table 6005 below descπbes the startmg and ending position of this segment on each transcript.

Table 6005 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_l 17 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6006 below describes the starting and ending position of this segment on each transcript.

Table 6006 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, FfUMVWF_PEA_l_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_ 1_P33. Segment cluster HUMVWF_PEA_l_node_l 19 according to the present invention can be found in the following transcript(s): HUMVWF_PEA_1_T49. Table 6007 below describes the starting and ending position of this segment on each transcript.

Table 6007 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_122 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6008 below describes the starting and ending position of this segment on each transcript.

Table 6008 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWF_PEA_1_P2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_125 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWFJPEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF JPEA_1_T45 and HUMVWF_PEA_1_T49. Table 6009 below describes the starting and ending position of this segment on each transcript.

Table 6009 - Segment location on transcripts

This segment can be found in the following protein(s): HUMVWF_PEA_1_P1,

HUMVWF_PEA_1JP2, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33.

Segment cluster HUMVWF_PEA_l_node_127 according to the present invention is supported by 145 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6010 below describes the starting and ending position of this segment on each transcript.

Table 6010 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1, HUMVWFJPE AJJP2 and HUMVWF_PEA_1_P32, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_132 according to the present invention is supported by 172 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T27, HUMVWF J^»EA J _T37, HUMVWF JPEAJ _T38, HUMVWF JPEA_1_T45 and HUMVWF_PEA_1_T49. Table 6011 below describes the starting and ending position of this segment on each transcript.

Table 6011 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF JPEA_ l_P20, HUMVWF J^>EA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1 and HUMVWF_PEA_1_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_134 according to the present invention can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF JPEA_1_T5, HUMVWF_PEA_1_T27, HUMVWF_PEA_1_T37, HUMVWF JPEAJ_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6012 below describes the starting and ending position of this segment on each transcript.

Table 6012 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P20, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1 and HUMVWF_PEA_1JP2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_135 according to the present invention can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T27, HUMVWFJPEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6013 below describes the starting and ending position of this segment on each transcript.

Table 6013 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P20, HUMVWF_PEA_1_P32 and 2438

3380

HUMVWFJPEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1 and HUMVWF JPEA_1JP2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l__node_136 according to the present invention can be found in the following transcript(s): HUMVWFJPEA_1_T1, HUMVWF_PEA_1_T5, HUMVWFJPEA_1_T27, HUMVWF_PEA_1_T37, HUMVWFJPEA_1_T38, HUMVWF JPEA_1_T45 and HUMVWF_PEA_1_T49. Table 6014 below describes the starting and ending position of this segment on each transcript.

Table 6014 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P20, HUMVWF_PEA_1_P32 and HUMVWF_PEA_1JP33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1 and HUMVWF_PEA_1_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_137 according to the present invention can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6015 below describes the starting and ending position of this segment on each transcript.

Table 6015 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_1_P32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): HUMVWF_PEA_1_P1 and HUMVWF JPEA_1_P2, since it is in the coding region for the corresponding transcript.

Segment cluster HUMVWF_PEA_l_node_138 according to the present invention is supported by 186 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HUMVWF_PEA_1_T1, HUMVWF_PEA_1_T5, HUMVWF_PEA_1_T27, HUMVWF_PEA_1_T37, HUMVWF_PEA_1_T38, HUMVWF_PEA_1_T45 and HUMVWF_PEA_1_T49. Table 6016 below describes the starting and ending position of this segment on each transcript.

Table 6016 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcriρt(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HUMVWF_PEA_l_P20, HUMVWFJPEAJJP32 and HUMVWF_PEA_1_P33. This segment can also be found in the following protein(s): 438

3382

HUMVWF_PEA_1_P1 and HUMVWF_PEA_1_P2, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER T79260

Cluster T79260 features 7 transcript(s) and 38 segment(s) of interest, the names for which are given in Tables 6017 and 6018, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6019.

Table 6017 - Transcripts of interest

Transcript Name

T79260 PEA 1 TlO

T79260 PEA 1 T15

T79260 PEA 1 T20

T79260 PEA 1 T22

T79260 PEA 1 T23

T79260 PEA 1 T24

T79260 PEA 1 T27

Table 6018 - Segments of interest

Segment Name

T79260 PEA 1 node 0

T79260 PEA 1 node 7

T79260 PEA 1 node 14

T79260 PEA 1 node 15

T79260 PEA 1 node 17

T79260 PEA 1 node 25

T79260 PEA 1 node 26

T79260 PEA 1 node 30

T79260 PEA 1 node 43

T79260 PEA 1 node 45

T79260 PEA 1 node 48

T79260 PEA 1 node 51

Table 6019 - Proteins of interest

These sequences are variants of the known protein Kinesin-like protein KIF2C (SwissProt accession identifier KF2C_HUMAN; known also according to the synonyms Mitotic centromere- associated kinesin; MCAK; Kinesin-like protein 6), referred to herein as the previously known protein. Protein Kinesin-like protein KIF2C is known or believed to have the following function(s): Present throughout the cell cycle, associates with centromeres at early prophase, and remains associated with the centromere until after telophase (By similarity). The sequence for protein Kinesin-like protein KIF2C is given at the end of the application, as "Kinesin-like protein KIF2C amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6020.

Table 6020 - Amino acid mutations for Known Protein

Protein Kinesin-like protein KIF2C localization is believed to be Cytoplasmic and nuclear (By similarity).

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: mitosis; cell proliferation, which are annotation(s) related to

Biological Process; microtubule motor; ATP binding; centromeric DNA binding, which are annotation(s) related to Molecular Function; and nucleus; kinesin, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster T79260 features 38 segment(s), which were listed in Table 6018 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster T79260_PEA_l_node_0 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260__PEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6021 below describes the starting and ending position of this segment on each transcript.

Table 6021 - Segment location on transcripts

This segment can be found in the following protein(s): T7926O_PEA_1JP18, T79260 PEA 1 P20 and T79260 PEA 1 P21.

Segment cluster T79260JPEA_l_node_7 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10. Table 6022 below describes the starting and ending position of this segment on each transcript.

Table 6022 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P10.

Segment cluster T79260_PEA_l_node_14 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10. Table 6023 below describes the starting and ending position of this segment on each transcript. Table 6023 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P10.

Segment cluster T79260_PEA_l_node_15 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript®: T79260_PEA_ I_TlO, T79260_PEA_l_T20, T79260_PEA__l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6024 below describes the starting and ending position of this segment on each transcript.

Table 6024 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21.

Segment cluster T79260_PEA_l_node_17 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6025 below describes the starting and ending position of this segment on each transcript.

Table 6025 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21.

Segment cluster T79260_PEA_l_node_25 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T15. Table 6026 below describes the starting and ending position of this segment on each transcript.

Table 6026 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): T79260_PEA_l_P14.

Segment cluster T79260_PEA_l_node_26 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l__T15. Table 6027 below describes the starting and ending position of this segment on each transcript.

Table 6027 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P14.

Segment cluster T79260_PEA_l_node_30 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15, T7926O_PEA_1_T2O, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6028 below describes the starting and ending position of this segment on each transcript.

Table 6028 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14, T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21.

Segment cluster T79260_PEA_l_node_43 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l _T15, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6029 below describes the starting and ending position of this segment on each transcript.

Table 6029 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14, T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21. Segment cluster T79260_PEA_l_node_45 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260J?EA_l_T23 and T79260_PEA_l_T24. Table 6030 below describes the starting and ending position of this segment on each transcript.

Table 6030 - Segment location on transcripts

This segment can be found in the following protein(s): T79260 PEA 1JP10, T79260JPEA_l_P14, T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA _l_P21.

Segment cluster T79260_PEA_l_node_48 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T20 and T79260JPEA_l_T22. Table 6031 below describes the starting and ending position of this segment on each transcript.

Table 6031 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P20. This segment can also be found in the following protein(s): T79260_PEA_l_P18, since it is in the coding region for the corresponding transcript. Segment cluster T79260_PEA_l_node_51 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T23 and T79260JPEA_l_T24. Table 6032 below describes the starting and ending position of this segment on each transcript.

Table 6032 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P20. This segment can also be found in the following protein(s): T79260_PEA_l_P21, since it is in the coding region for the corresponding transcript.

Segment cluster T79260_PEA_l_node_63 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15 and T79260_PEA_l_T27. Table 6033 below describes the starting and ending position of this segment on each transcript.

Table 6033 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260 PEA 1 P14 and T79260 PEA 1 P23.

Segment cluster T79260_PEA_l_node_65 according to the present invention is supported by 85 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15 and T79260JPEA_l_T27. Table 6034 below describes the starting and ending position of this segment on each transcript.

Table 6034 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260 PEA 1 P14 and T79260 PEA 1 P23.

Segment cluster T79260JPEA_l_node_66 according to the present invention is supported by 82 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260JPEA_l_T15 and T79260_PEA_l_T27. Table 6035 below describes the starting and ending position of this segment on each transcript.

Table 6035 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14 and T79260_PEA_l_P23.

Segment cluster T79260_PEA_l_node_67 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15 and T79260_PEA_l_T27. Table 6036 below describes the starting and ending position of this segment on each transcript.

Table 6036 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P10, T79260JPEAJJP14 and T79260_PEA_l_P23.

Segment cluster T79260JPEA_l_node_69 according to the present invention is supported by 64 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15 and T79260_PEA_l_T27. Table 6037 below describes the starting and ending position of this segment on each transcript. Table 6037 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T79260JPEAJJP10, T79260_PEA_l_P14 and T79260_PEA_l_P23.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster T79260_PEA_l_node_4 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T20, T79260_PEA_l_T22, 2005/002438

3393

T79260JPEA_l_T23 and T79260_PEAJ_T24. Table 6038 below describes the starting and ending position of this segment on each transcript.

Table 6038 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_JPEA_l_P18, T79260 PEA 1 P20 and T79260 PEA 1 P21.

Segment cluster T79260_PEA_l_node_9 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T20, T79260JPEA_l_T22, T79260_PEA_l_T23 and T79260JPEA_l_T24. Table 6039 below describes the starting and ending position of this segment on each transcript.

Table 6039 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 6040.

Table 6040 - Oligonucleotides related to this segment

T79260 0 21 0 ovarian carcinoma OVA

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P10. This segment can also be found in the following protein(s): T7926O_PEA_1JP18, T79260_PEA_l_P20 and T79260_PEA_l_P21, since it is in the coding region for the corresponding transcript.

Segment cluster T79260_PEA_l_node_10 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T7926O_PEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6041 below describes the starting and ending position of this segment on each transcript.

Table 6041 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P10. This segment can also be found in the following protein(s): T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21, since it is in the coding region for the corresponding transcript.

Segment cluster T79260_PEA_ l_node_12 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6042 below describes the starting and ending position of this segment on each transcript. 5 002438

3395

Table 6042 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P10. This segment can also be found in the following protein(s): T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21, since it is in the coding region for the corresponding transcript.

Segment cluster T79260_PEA_l_node_19 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA__l_T10, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260JPEA_l_T23 and T79260_PEA_l_T24. Table 6043 below describes the starting and ending position of this segment on each transcript.

Table 6043 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P18, T79260_PEA_lJ^>20 and T79260JPEAJJP21.

Segment cluster T79260_PEA_l_node_20 according to the present invention is supported by 60 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260_PEA _l_T23 and T79260_PEA_l_T24. Table 6044 below describes the starting and ending position of this segment on each transcript.

Table 6044 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21.

Segment cluster T79260_PEA_l_node_23 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6045 below describes the starting and ending position of this segment on each transcript.

Table 6045 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEAJ_P21.

Segment cluster T79260_PEA_l_node_27 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l _TlO, T79260_PEA_l_T15, T79260JPEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6046 below describes the starting and ending position of this segment on each transcript.

Table 6046 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l JPlO, T79260_PEA_l_P14, T79260_PEA_l_ P18, T7926O_PEA_1JP2O and T79260_PEA_l_P21.

Segment cluster T79260_PEA_l_node_32 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260JPEA_l_T10, T79260JPEA_l_T15, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6047 below describes the starting and ending position of this segment on each transcript.

Table 6047 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14, T79260_PEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21. Segment cluster T79260_PEA_l_node_34 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260JPEA_ l_T15, T79260_PEA_l_T20, T79260JPEA_l _T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6048 below describes the starting and ending position of this segment on each transcript.

Table 6048 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA 1JP14, T79260_PEA 1_P18, T79260_PEA 1 P20 and T79260 PEA_1_P21.

Segment cluster T79260_PEA_l_node_36 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15, T79260_PEA_l_T20, T79260_PEA_l_T22, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6049 below describes the starting and ending position of this segment on each transcript.

Table 6049 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14, T79260JPEA_l_P18, T79260_PEA_l_P20 and T79260_PEA_l_P21. Segment cluster T79260_PEA_l_node_46 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260JPEAJ_T22 and T79260_PEA_l_T23. Table 6050 below describes the starting and ending position of this segment on each transcript.

Table 6050 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P20.

Segment cluster T79260_PEA_l_node_47 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15, T79260_PEA_l_T20, T79260_PEA_l_T22 and T79260_PEA_l_T23. Table 6051 below describes the starting and ending position of this segment on each transcript. Table 6051 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14, T79260_PEA_l_P18 and T79260_PEA_l_P20.

Segment cluster T79260_PEA_l_node_50 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15, T79260_PEA_l_T23 and T79260_PEA_l_T24. Table 6052 below describes the starting and ending position of this segment on each transcript.

Table 6052 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260JPEA_l_P20. This segment can also be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14 and T79260_PEA_l_P21, since it is in the coding region for the corresponding transcript.

Segment cluster T79260_PEA_l_node_53 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T27. Table 6053 below describes the starting and ending position of this segment on each transcript.

Table 6053 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260JPEA_l_P23.

Segment cluster T79260_PEA_l_node_54 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T27. Table 6054 below describes the starting and ending position of this segment on each transcript.

Table 6054 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l JP23.

Segment cluster T79260_PEA_l_node_55 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T27. Table 6055 below describes the starting and ending position of this segment on each transcript.

Table 6055 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P23.

Segment cluster T79260_PEA_l_node_56 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l _TlO, T79260_PEA_l_T15 and T79260_PEA_l_T27. Table 6056 below describes the starting and ending position of this segment on each transcript.

Table 6056 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260 PEA 1 P14 and T79260 PEA 1 P23. Segment cluster T79260_PEA_l_node_57 according to the present invention can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15 and T79260_PEA_l_T27. Table 6057 below describes the starting and ending position of this segment on each transcript.

Table 6057 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14 and T79260_PEA_l_P23.

Segment cluster T79260_PEA_l_node_59 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): T79260_PEA_l_T10, T7926OJPEA_1_T15 and T79260_PEA_l_T27. Table 6058 below describes the starting and ending position of this segment on each transcript. Table 6058 - Segment location on transcripts

This segment can be found in the following protein(s): T79260_PEA_l_P10, T79260 PEA 1 P14 and T79260 PEA 1 P23.

Segment cluster T79260_PEA_l_node_68 according to the present invention can be found in the following transcript(s): T79260_PEA_l_T10, T79260_PEA_l_T15 and T79260_PEA_l_T27. Table 6059 below describes the starting and ending position of this segment on each transcript. Table 6059 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): T79260_PEA_l_P10, T79260_PEA_l_P14 and T79260_PEA_l_P23.

DESCRIPTION FOR CLUSTER Z17844

Cluster Z 17844 features 2 transcript(s) and 54 segment(s) of interest, the names for which are given in Tables 6060 and 6061, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6062.

Table 6060 - Transcripts of interest

Transcript Name

Z17844 PEA 1 T5

Z17844 PEA 1 T31

Table 6061 - Segments of interest

Segmeni Name

Z17844 PEA 1 node 11

Z17844 PEA 1 node 13

Zl 7844 PEA 1 node 16

Zl 7844 PEA 1 node 33

Z17844 PEA 1 node 35

Z17844 PEA 1 node 59

Z17844 PEA 1 node 83

Z17844 PEA 1 node 0

Z17844 PEA 1 node 7 Zl 7844 PEA 1 node 8

Z 17844 PEA 1 node 20

Z17844 PEA 1 node 23

Zl 7844 PEA 1 node 24

Zl 7844 PEA 1 node 25

Z 17844 PEA 1 node 29

Zl 7844 PEA 1 node 30

Zl 7844 PEA 1 node 31

Zl 7844 PEA 1 node 32

Z17844_ _PEA_ 1_ node_ 34

Zl 7844 PEA 1 node 38

Z17844 PEA 1 node 39

Z17844 PEA 1 node 40

Zl 7844 PEA 1 node 43

Z17844 PEA 1 node 44

Zl 7844 PEA 1 node 45

Z17844 PEA 1 node 46

Zl 7844 PEA 1 node 47

Zl 7844 PEA 1 node 48

Z17844 PEA 1 node 49

Zl 7844 PEA 1 node 50

Zl 7844 PEA 1 node 51

Zl 7844 PEA 1 node 52

Zl 7844 PEA 1 node 53

Z17844 PEA 1 node 54

Z17844_ _PEA_ _1_ node _55

Z17844 PEA 1 node 56

Z 17844 PEA 1 node 60

Z17844 PEA 1 node 61

Z17844 PEA 1 node 62

Z17844 PEA 1 node 63

Zl 7844 PEA 1 node 65

Z17844 PEA 1 node 66

Zl 7844 PEA 1 node 69

Z17844 PEA 1 node 70

Zl 7844 PEA 1 node 71

Z17844 PEA 1 node 72

Z17844 PEA 1 node 73

Zl 7844 PEA 1 node 74

Zl 7844 PEA 1 node 75

Z17844 PEA 1 node 76

Z17844 PEA 1 node 79

Z17844 PEA 1 node 80

Zl 7844 PEA 1 node 81 [ Zl 7844 PEA 1 node_82

Table 6062 - Proteins of interest

These sequences are variants of the known protein Major vault protein (SwissProt accession identifier MVP HUMAN; known also according to the synonyms MVP; Lung resistance- related protein), referred to herein as the previously known protein.

Protein Major vault protein is known or believed to have the following function(s): Unknown, though MVP is required for normal vault structure. Vaults are multi-subunit structures that may be involved in nucleo- cytoplasmic transport. The sequence for protein Major vault protein is given at the end of the application, as "Major vault protein amino acid sequence". Protein Major vault protein localization is believed to be CYTOPLASMIC, 5% ARE NUCLEUS ASSOCIATED AND LOCALIZE TO THE NUCLEAR PORE COMPLEXES.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: nucleus; cytoplasm, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

As noted above, cluster Z17844 features 54 segment(s), which were listed in Table 6061 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster Z17844_PEA_l_node_l l according to the present invention is supported by 163 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6063 below describes the starting and ending position of this segment on each transcript.

Table 6063 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844JPEA_l_node_13 according to the present invention is supported by 126 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6064 below describes the starting and ending position of this segment on each transcript.

Table 6064 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_16 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6065 below describes the starting and ending position of this segment on each transcript.

Table 6065 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32. Segment cluster Zl 7844_PEA_l_node_33 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6066 below describes the starting and ending position of this segment on each transcript.

Table 6066 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_35 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6067 below describes the starting and ending position of this segment on each transcript.

Table 6067 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844J?EA_l_node_59 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T31. Table 6068 below describes the starting and ending position of this segment on each transcript.

Table 6068 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P24.

Segment cluster Z17844_PEA_l_node_83 according to the present invention is supported by 183 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6069 below describes the starting and ending position of this segment on each transcript.

Table 6069 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844JPEA_1JP24, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Zl 7844_PEA_l_node_0 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6070 below describes the starting and ending position of this segment on each transcript.

Table 6070 - Segment location on transcripts

This segment can be found in a non-coding region of traπscript(s) that are related to the following protein(s): Z17844_PEA_1JP32.

Segment cluster Z17844_PEA_l__node_7 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6071 below describes the starting and ending position of this segment on each transcript.

Table 6071 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_8 according to the present invention is supported by 161 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6072 below describes the ^"starting and ending position of this segment on each transcript.

Table 6072 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844JPEA_ l_node_20 according to the present invention is supported by 100 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6073 below describes the starting and ending position of this segment on each transcript.

Table 6073 - Segment location on transcripts

I Z17844 _PEA_1_T5 | 717 | 811 |

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_nodeJ_3 according to the present invention is supported by 90 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s)- Z17844_PEA_1_T5. Table 6074 below describes the starting and ending position of this segment on each transcript.

Table 6074 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_1 _node_24 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6075 below describes the starting and ending position of this segment on each transcript.

Table 6075 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_25 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6076 below describes the starting and ending position of this segment on each transcript.

Table 6076 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844JPEA_l_node_29 according to the present invention is supported by 86 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6077 below describes the starting and ending position of this segment on each transcript.

Table 6077 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1JP32.

Segment cluster Z17844_PEA_l_node_30 according to the present invention is supported by 89 libraries. THe numbeFδf Iibraries^~was^"(ieterrήrne3. alfprevϊoϋsly described.^~This^" segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6078 below describes the starting and ending position of this segment on each transcript.

Table 6078 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_31 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6079 below describes the starting and ending position of this segment on each transcript.

Table 6079 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_32 according to the present invention is supported by 96 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6080 below describes the starting and ending position of this segment on each transcript.

Table 6080 - Segment location on transcripts

This segment can be found in the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_34 according to the present invention is supported by 1 IB libraries. The^*number of libraries was determined as previously described. ThiFsegnient can be found in the following transcript(s): Z17844_PEA_1__T5. Table 6081 below describes the starting and ending position of this segment on each transcript.

Table 6081 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_38 according to the present invention is supported by 124 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6082 below describes the starting and ending position of this segment on each transcript. Table 6082 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_39 according to the present invention is supported by 132 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6083 below describes the starting and ending position of this segment on each transcript.

Table 6083 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_40 according to the present invention is supported by 118 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6084 below describes the starting and ending position of this segment on each transcript.

Table 6084 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. Segment cluster Z17844_PEA_l_node_43 according to the present invention is supported by 132 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6085 below describes the starting and ending position of this segment on each transcript.

Table 6085 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_44 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6086 below describes the starting and ending position of this segment on each transcript.

Table 6086 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844JPEA_1_P32.

Segment cluster Z17844_PEA_l_node_45 according to the present invention is supported by 135 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844JPEA_1_T5. Table 6087 below describes the starting and ending position of this segment on each transcript.

Table 6087 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844JPEA_1_P32.

Segment cluster Z17844_PEA_l_node_46 according to the present invention is supported by 152 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6088 below describes the starting and ending position of this segment on each transcript.

Table 6088 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_47 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6089 below describes the starting and ending^"pbsition of this segment on each transcript.

Table 6089 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1 JP32.

Segment cluster Z17844_PEA_l_node_48 according to the present invention is supported by 145 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6090 below describes the starting and ending position of this segment on each transcript. Table 6090 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844JPEA_1JP32.

Segment cluster Z17844_PEA_l_node_49 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6091 below describes the starting and ending position of this segment on each transcript.

Table 6091 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844JPEAJJP32.

Segment cluster Z17844_PEA_l_node_50 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6092 below describes the starting and ending position of this segment on each transcript.

Table 6092 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_ljiode_51 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6093 below describes the starting and ending position of this segment on each transcript. Table 6093 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1JP32.

Segment cluster Z17844_PEA_l_node_52 according to the present invention can be found in the following transcript(s): Z17844JPEA_1_T5. Table 6094 below describes the starting and ending position of this segment on each transcript.

Table 6094 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1 J^>32.

Segment cluster Z17844_PEA_l_node_53 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6095 below describes the starting and ending position of this segment on each transcript.

Table 6095 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844JPEA_l_node_54 according to the present invention is supported by 141 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6096 below describes the starting and ending position of this segment on each transcript.

Table 6096 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32.

Segment cluster Zl 7844_PEA_l_node_55 according to the present invention can be found in the following transcript(s): Z17844JPEA_1_T5. Table 6097 below describes the starting and ending position of this segment on each transcript.

Table 6097 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to me following protein(s): Z17844_PEA_1_P32.

Segment cluster Z17844_PEA_l_node_56 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5. Table 6098 below describes the starting and ending position of this segment on each transcript.

Table 6098 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. Segment cluster Z17844_PEA_l_node_60 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844JPEA_1_T31. Table 6099 below describes the starting and ending position of this segment on each transcript.

Table 6099 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_61 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA__1_T31. Table 6100 below-describes the starting and-ending position of this- segment on each-transcript. — Table 6100 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_62 according to the present invention is supported by 170 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6101 below describes the starting and ending position of this segment on each transcript. Table 6101 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844JPEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_63 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6102 below describes the starting and ending position of this segment on each transcript.

Table 6102 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844JPEA_l_node_65 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6103 below describes the starting and ending position of this segment on each transcript.

Table 6103 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844JPEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_66 according to the present invention is supported by 202 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844JPEA_1_T5 and Z17844_PEA_1_T31. Table 6104 below describes the starting and ending position of this segment on each transcript.

Table 6104 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_69 according to the present invention is supported by 193 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6105 below describes the starting and ending position of this segment on each transcript.

Table 6105 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be fcund in a non-coding region of transcript(s) that are related to the following protem(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node__70 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844JPEA J_T31. Table 6106 below describes the starting and ending position of this segment on each transcript.

Table 6106 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

-Segment &luster-Z17844_REA— l—node-71-according-to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6107 below describes the starting and ending position of this segment on each transcript.

Table 6107 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript. Segment cluster Z17844_PEA_l_node_72 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6108 below describes the starting and ending position of this segment on each transcript.

Table 6108 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_73 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6109 below describes the starting and ending position of this segment on each transcript.

^~Table 6TO9 - Segment locaffώϊ on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_74 according to the present invention is supported by 195 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6110 below describes the starting and ending position of this segment on each transcript. Table 6110 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_75 according to the present invention can be found in the following transcript(s): Z17844 _PEA_1_T5 and Z17844JPEA_1_T31. Table 6111 below describes the starting and ending position of this segment on each transcript.

Table 6111 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_76 according to the present invention is supported by 194 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844JPEA_1_T5 and Z17844_PEA_1_T31.

Table 6112 below describes the starting and ending position of this segment on each transcript.

Table 6112 - Segment location on transcripts

Z17844 PEA 1 T31 932 974

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_79 according to the present invention can be found in the following transcript(s): Z17844JPEA_1_T5 and Z17844_PEA_1_T31. Table 6113 below describes the starting and ending position of this segment on each transcript. Table 6113 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEAjl_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_80 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6114 below describes the starting and ending position of this segment on each transcript. Table 6114 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Z17844_PEA_l_node_81 according to the present invention is supported by 211 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z17844JPEA_1_T5 and Z17844_PEA_1_T31. Table 6115 below describes the starting and ending position of this segment on each transcript.

Table 6115 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript.

Segment cluster Zl 7844_PEA_l_node_82 according to the present invention can be found in the following transcript(s): Z17844_PEA_1_T5 and Z17844_PEA_1_T31. Table 6116 below describes the starting and ending position of this segment on each transcript.

Table 6116 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z17844_PEA_1_P32. This segment can also be found in the following protein(s): Z17844_PEA_1_P24, since it is in the coding region for the corresponding transcript. DESCRIPTION FOR CLUSTER Zl 8303

Cluster Zl 8303 features 6 transcript(s) and 46 segment(s) of interest, the names for which are given in Tables 6117 and 6118, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6119.

Table 6117 ^' - Transcripts of interest

Transcript Name

Zl 8303 PEA 1 T2

Zl 8303 PEA 1 T8

Zl 8303 PEA 1 TlO

Zl 8303 PEA 1 T12

Z18303 PEA 1 T24

Zl 8303 PEA 1 T39

Table 6118 - Segments of interest

Segment Name

Zl 8303 PEA 1 node 3

Zl 8303 PEA 1 node 10

Zl 8303 PEA 1 node 29

Zl 8303 PEA 1 node 30

Zl 8303 PEA 1 node 31

Zl 8303 PEA 1 node 33

Zl 8303 PEA 1 node 34

Zl 8303 PEA 1 node 39

Zl 8303 PEA 1 node 49

Zl 8303 PEA 1 node 58

Zl 8303 PEA 1 node 66

Zl 8303 PEA 1 node 67

Zl 8303 PEA 1 node 73

Zl 8303 PEA 1 node 77

Zl 8303 PEA 1 node 80

Zl 8303 PEA 1 node 86

Zl 8303 PEA 1 node 89

Zl 8303 PEA 1 node 95

Zl 8303 PEA 1 node 99 Zl 8303 PEA 1 node 102

Zl 8303 PEA 1 node 104

Zl 8303 PEA 1 node 107

Zl 8303 PEA 1 node 0

Zl 8303 PEA 1 node 1

Zl 8303 PEA 1 node 6

Zl 8303 PEA 1 node 8

Zl 8303 PEA 1 node 13

Zl 8303 PEA 1 node 16

Zl 8303 PEA 1 node 18

Zl 8303 PEA 1 node 22

Zl 8303 PEA 1 node 27

Zl 8303 PEA 1 node 28

Zl 8303 PEA 1 node 35

Zl 8303 PEA 1 node 36

Zl 8303 PEA 1 node 42

Zl 8303 PEA 1 node 45

Zl 8303 PEA 1 node 46

Zl 8303 PEA 1 node 52

Zl 8303 PEA 1 node 54

Zl 8303 PEA 1 node 62

Zl 8303 PEA 1 node 63

Zl 8303 PEA 1 node 65 aJPEΔ_ijaDde.7L

Zl 8303 PEA 1 node 82

Zl 8303 PEA 1 node 103

Zl 8303 PEA 1 node 105

Table 6119 - Proteins of interest

These sequences are variants of the known protein Myosin-binding protein C, cardiac- type (SwissProt accession identifier MYPC_HUMAN; known also according to the synonyms Cardiac MyBP-C; C-protein, cardiac muscle isoform), referred to herein as the previously known protein. Protein Myosin-binding protein C, cardiac-type is known or believed to have the following function(s): Thick filament- associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-actived myosin ATPase. It may modulate muscle contraction or may play a more structural role. The sequence for protein Myosin-binding protein C, cardiac- type is given at the end of the application, as "Myosin-binding protein C, cardiac-type amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6120.

Table 6120 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: muscle contraction; striated muscle contraction regulation; cell adhesion; muscle development, which are annotation(s) related to Biological Process; actin binding; protein binding; structural protein of muscle, which are annotation(s) related to Molecular Function; and muscle thick filament; actin cytoskeleton, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster Z18303. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 143 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histogram in

Figure 143, concerning the number of heart- specific clones in libraries/sequences; as well as with regard to the histogram in Figure 144, concerning the actual expression of oligonucleotides in various tissues, including heart.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 27.2; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 58.7; and fisher exact test P-values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be l.30E-61.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 27.2, which clearly supports specific expression in heart tissue.

As noted above, cluster Zl 8303 features 46 segment(s), which were listed in Table 6118 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z18303_PEA_l_node_3 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6121 below describes the starting and ending position of this segment on each transcript.

Table 6121 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z183O3_PEA_1JP3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_10 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Zl 8303_PEA_l_T12 and Zl 8303 JPEA_1_T39. Table 6122 below describes the starting and ending position of this segment on each transcript.

Table 6122 - Segment location on transcripts

|_Z18303 _PEA_1_T39 561 709

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_29 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2 and Z18303_PEA_l_T39. Table 6123 below describes the starting and ending position of this segment on each transcript.

Table 6123 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_30 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6124 below describes the starting and ending position of this segment on each transcript.

Table 6124 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z183O3_PEA_1_P35. This segment can also be found in the following protein(s): Z18303JPEA_l_P3, Z18303_PEA_l_P10 and Z18303JPEAJ JP12, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_31 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Zl 8303_PEA_l_T39. Table 6125 below describes the starting and ending position of this segment on each transcript.

Table 6125 - Segment location on transcripts

Transcript name Segment, Segment starting position ending position

Zl 8303 PEA 1 T39 1402 3545

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P35.

Segment cluster Z18303_PEA_l_node_33 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T8. Table 6126 below describes the starting and ending position of this segment on each transcript.

Table 6126 - Segment location on transcripts

This segment can be found in a non- coding region of transcripts) that are related to the following protein(s): Z183O3_PEA_1_P8. Segment cluster Z18303_PEA_l_node_34 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T8. Table 6127 below describes the starting and ending position of this segment on each transcript.

Table 6127 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P8.

Segment cluster Z18303_PEA_l_node_39 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10 and Z18303_PEA_l_T12. Table 6128 below describes the starting and

Table 6128 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303JPEA_lJP3, Z18303_PEA_l_P8, Z18303JPEA_l_P10 and Z18303_PEA_l_P12.

Segment cluster Z18303_PEA_l_node_49 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10 and Z18303JPEAJ_T12. Table 6129 below descπbes the starting and ending position of this segment on each transcript.

Table 6129 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_l_P3,

Z18303JPEAJ P8, Z18303_PEA_l_P10 and Z18303_PEA_l_P12.

Segment cluster Z18303_PEA_l_node_58 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8,

Z18303JPEAJ _TlO and Z18303_PEA_l_T12. Table 6130 below describes the starting and ending position of this segment on each transcript.

Table 6130 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_l_P3,

Z18303_PEA_l_P8, Z18303_PEA_l_P10 and Z18303_PEA_l_P12.

Segment cluster Z18303_PEA_l_node_66 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Zl 8303_PEA_l_T2, Zl 8303_PEA_l_T8,

Zl 8303JPEAJJNO, Z18303JPEAJ _T12 and Z18303 JPEAJ _T24. Table 6131 below describes the starting and ending position of this segment on each transcript. Table 6131 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z18303JPEA_ l_P20. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P10 and Z18303JPEA_l_P12, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node__67 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T10 and Z18303_PEA_l_T24. Table-δl^S-below-deseribes-the-starting-and-ending position-of-this-segment-on-eaeh-transeriptT—

Table 6132 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303JPEA_l_P20. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_73 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303JPEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6133 below describes the starting and ending position of this segment on each transcript.

Table 6133 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P10. This segment can also be found in the following protein(s): Z183O3_PEA_1_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P12 and Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_77 according to the present invention is supported by-^-8-librariesτ-The-number-of-libraries was determined as-previously-described:-T-his-segment— - can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303JPEA_l_T8, Z18303_PEA_l_T10, Z18303JPEA_l_T12 and Z18303_PEA_l_T24. Table 6134 below describes the starting and ending position of this segment on each transcript.

Table 6134 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Zl 8303_PEA_l_P10. This segment can also be found in the following protein(s): Z183O3_PEA_1JP3, Z18303_PEA_l_P8, Z18303_PEA_l_P12 and Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_80 according to the present invention is supported by 32 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6135 below describes the starting and ending position of this segment on each transcript.

Table 6135 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as -follows .-The-segment- can be found-in-a-non- coding region of transcript(s)-that are related to-the- following protein(s): Z183O3_PEA_1_P1O. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P12 and Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303JPEA_l_node_86 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303JPEA_l_T8, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6136 below describes the starting and ending position of this segment on each transcript.

Table 6136 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P10. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P12 and

Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_89 according to the present invention is supported by 31 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8,

Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6137 below describes the starting and ending position of this segment on each transcript.

Table 6137 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z183O3JPEA_1JP1O. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P12 and Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_95 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303JPEA_l_T8, Z18303_PEA_l_T10, Z18303__PEA_l_T12 and Z18303_PEA_l_T24. Table 6138 below describes the starting and ending position of this segment on each transcript.

Table 6138 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P10. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P12 and Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_99 according to the present invention is supported — by-32-libraries7-T-he~nurnbeρ of-libraries was-determined as previously described-This segment- can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6139 below describes the starting and ending position of this segment on each transcript.

Table 6139 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P10. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEAJ_P8, Z183O3_PEA_1JP12 and Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcnpt.

Segment cluster Z18303_PEA_l_node_102 according to the present invention is supported by 35 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303JPEA_l_T8, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6140 below describes the starting and ending position of this segment on each transcript.

Table 6140 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as followsr The-segment-can be found-in-a-non- coding-region of-transcript(s) that are related-to-the- following protein(s): Z18303_PEA_l_P10. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P12 and Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_104 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T12. Table 6141 below describes the starting and ending position of this segment on each transcript.

Table 6141 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_l_P12. Segment cluster Z18303_PEA_l_node_107 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Zl 8303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10, Z18303_PEA__l_T12 and Z18303J^»EA_l_T24. Table 6142 below describes the starting and ending position of this segment on each transcript.

Table 6142 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P10, Z18303 PEA 1 P12 and Z18303 PEA 1 P20.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z18303_PEA_l_node_0 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Zl 8303_PEA_l_T2, Zl 8303_PEA_l_T10,

Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6143 below describes the starting and ending position of this segment on each transcript.

Table 6143 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303JPEAJJP35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_l according to the present invention can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6144 below describes the starting and ending position of this segment on each transcript.

Table 6144 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l__node_6 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_ l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6145 below describes the starting and ending position of this segment on each transcript. Table 6145 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_8 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6146 below describes the starting and ending position of this segment on each transcript. Table 6146 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript. Segment cluster Z18303_PEA_l_node_13 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6147 below describes the starting and ending position of this segment on each transcript.

Table 6147 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_16 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6148 below describes the starting and ending position of this segment on each transcript.

Table 6148 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303__PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_18 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303JPEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6149 below describes the starting and ending position of this segment on each transcript.

Table 6149 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_lJP3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_22 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10,

Z183O3_PEA_1_T12 and Z18303_PEA_l_T39. Table 6150 below describes the starting and ending position of this segment on each transcript.

Table 6150 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303JPEAJJP12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_27 according to the present invention can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T39. Table 6151 below describes the starting and ending position of this segment on each transcript.

Table 6151 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_l_P35, since it is in the coding region for the corresponding transcript.

Segment cluster Zl 8303_PEA_l_node_28 according to the present invention can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303JPEA_l_T39. Table 6152 below describes the starting and ending position of this segment on each transcript.

Table 6152 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P3. This segment can also be found in the following protein(s): Z18303_PEA_l_P10, Z18303_PEA_l_P12 and Z18303_PEA_lJP35, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_35 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10 and Z18303JPEA_l_T12. Table 6153 below describes the starting and ending position of this segment on each transcript.

Table 6153 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P8. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P10 and Z183O3_PEA_1JP12, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_36 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z183O3_PEA_1_T1O and Z 18303 J³EAJ_Tl 2. Table 6154 below describes the starting and ending position of this segment on each transcript.

Table 6154 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_l_P3, Zl 8303 JPEA J JP8, Z18303_PEA_l_P10 and Z18303JΕAJJP12.

Segment cluster Zl 8303 JPEAJ _node_42 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Zl 8303 JPEA J _T2, Zl 8303 JPEA J _T8, Zl 8303J⁵EAJ_TlO and Zl 8303 JPEA J _Tl 2. Table 6155 below describes the starting and ending position of this segment on each transcript.

Table 6155 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303JPEAJ JP3, Z18303_PEAJ_P8, Z 18303J¹EAJJP 10 and Z18303_PEAJ_P12.

Segment cluster Zl 8303 JPEAJ _node_45 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Zl 8303 JPEA J _T2, Z18303_PEA_l_T8, Z18303JPEA_l_T10 and Z18303_PEA_l_T12. Table 6156 below describes the starting and ending position of this segment on each transcript.

Table 6156 - Segment location on transcripts

This segment can be found in the following protein(s): Z183O3JPEA_1JP3, Z18303JPEAJJP8, Z18303_PEA_l_P10 and Z18303_PEA_l_P12.

Segment cluster Z18303_PEA_l_node_46 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10 and Z18303_PEA_l_T12. Table 6157 below describes the starting and ending position of this segment on each transcript.

Table 6157 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_ l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P10 and Z18303_PEA_l_P12.

Segment cluster Z18303_PEA_l_node_52 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Zl 8303_PEA_l_T2, Zl 8303_PEA_l_T8,

Z18303_PEA_l_T10 and Z18303_PEA_l_T12. Table 6158 below describes the starting and ending position of this segment on each transcript. Table 6158 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_l_P3, Z18303 PEAJ P8, Z18303 PEA_l_P10 and Z18303_PEA 1JP12.

Segment cluster Z18303_PEA_l_node_54 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303JPEA_l_T2, Z18303_PEA_ l_T8, Z18303_PEA_l_T10 and Z18303_PEA_l_T12. Table 6159 below describes the starting and ending position of this segment on each transcript.

Table 6159 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P10 and Z18303_PEA_l_P12.

Segment cluster Z18303_PEA_l_node_62 according to the present invention can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10 and Z18303_PEA_l_T12. Table 6160 below describes the starting and ending position of this segment on each transcript. Table 6160 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P10 and Z18303_PEA_l_P12.

Segment cluster Z18303_PEA_l_node_63 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10 and Z18303_PEA_l_T12. Table 6161 below describes the starting and ending position of this segment on each transcript.

Table 6161 - Segment location on transcripts

This segment can be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303JPEAJJP10 and Z18303_PEAJ_P12.

Segment cluster Zl 8303_PEA_l_node_65 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T24. Table 6162 below describes the starting and ending position of this segment on each transcript.

Table 6162 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_1_P20.

Segment cluster Zl 8303_PEA_l_node_71 according to the present invention is supported by 24 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Zl 8303JPEAJ_Tl 0, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6163 below describes the starting and ending position of this segment on each transcript.

Table 6163 - Segment location on transcripts

This_segment can_be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P20. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P10 and Z18303_PEA_l_P12, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_82 according to the present invention is supported by 29 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6164 below describes the starting and ending position of this segment on each transcript.

Table 6164 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z183O3_PEA_1_P1O. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303JPEA_l_P8, Z18303_PEA_l_P12 and

Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303JPEA_l_node_103 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10, Z18303_PEA_l_T12 and Z18303_PEA_l_T24. Table 6165 below describes the starting and ending position of this segment on each transcript.

Table 6165 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z18303_PEA_l_P10. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8, Z18303_PEA_l_P12 and Z183O3_PEA_1JP2O, since it is in the coding region for the corresponding transcript.

Segment cluster Z18303_PEA_l_node_105 according to the present invention is supported by 28 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z18303_PEA_l_T2, Z18303_PEA_l_T8, Z18303_PEA_l_T10, Z18303JPEA_l_T12 and Z18303_PEA_l_T24. Table 6166 below describes the starting and ending position of this segment on each transcript.

Table 6166 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z183O3_PEA_1 J^>10 and Z18303_PEA_l_P12. This segment can also be found in the following protein(s): Z18303_PEA_l_P3, Z18303_PEA_l_P8 and Z18303_PEA_l_P20, since it is in the coding region for the corresponding transcript.

DESCRIPTION FOR CLUSTER Z30117

Cluster Z30117 features 6 transcript(s) and 47 segment(s) of interest, the names for which are given in Tables 6167 and 6168, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6169.

Table 6167 - Transcripts of interest

Transcript Name

Z30117 PEA 1 T9

Z30117 PEA 1 TIl

Z30117 PEA 1 T12

Z30117 PEA 1 T13

Z30117 PEA 1 T15 Z30117 PEA 1 T16

Table 6168 - Segments of interest

Segment Name

Z30117 PEA 1 node 0

Z30117 PEA 1 node 5

Z30117 PEA 1 node 7

Z30117 PEA 1 node 9

Z30117 PEA 1 node 19

Z30117 PEA 1 node 21

Z30117 PEA 1 node 23

Z30117 PEA 1 node 25

Z30117 PEA 1 node 32

Z30117 PEA 1 node 34

Z30117 PEA 1 node 36

Z30117 PEA 1 node 38

Z30117 PEA 1_ node 43

Z30117 PEA 1 node 47

Z30117 PEA 1 node 54

Z30117 PEA 1 node 56

Z30117 PEA 1 node 62

Z30117 PEA 1 node 64

Z30117-PEA- 1 node—72- — —

Z30117 PEA 1 node 79

Z30117 PEA 1 node 82

Z30117 PEA 1 node 86

Z30117 PEA 1 node 93

Z30117 PEA 1 node 95

Z30117 PEA 1 node 2

Z30117 PEA 1 node 11

Z30117 PEA 1 node 15

Z30117 PEA 1 node 17

Z30117 PEA 1 node 27

Z30117 PEA 1 node 29

Z30117 PEA 1 node 30

Z30117 PEA 1 node 40

Z30117 PEA 1 node 41

Z30117 PEA 1 node 45

Z30117 PEA 1 node 49

Z30117 PEA 1 node 50

Z30117 PEA 1 node 52

Z30117 PEA 1 node 58

Z30117 PEA 1 node 60 Z301 17 PEA 1 node 66

Z301 17 PEA 1 node 68

Z301 17 PEA 1 node 70

Z301 17 PEA 1 node 74

Z301 17 PEA 1 node 81

Z301 17 PEA 1 node 83

Z301 17 PEA 1 node 87

Z30117 PEA 1 node 92

Table 6169 - Proteins of interest

These sequences are variants of the known protein Myomesin 2 (SwissProt accession identifier MYM2JHUMAN; known also according to the synonyms M-protein; 165 kDa titin- associated protein; 165 kDa connectin- associated protein), referred to herein as the previously known protein.

Protein Myomesin 2 is known or believed to have the following function(s): Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. The sequence for protein Myomesin 2 is given at the end of the application, as "Myomesin 2 amino acid sequence".

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: muscle contraction; striated muscle contraction; muscle development, which are annotation(s) related to Biological Process; structural protein of muscle, which are annotation(s) related to Molecular Function; and muscle thick filament, which are annotation(s) related to Cellular Component. The GO assignment relies on infoπnation from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi .nlm .nih. gov/proj ects/LocusLink/> .

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster Z30117. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 145 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 145, concerning the number of heart- specific clones in libraries/sequences; as well as with regard to the histogram in Figure 146, concerning the actual expression of oligonucleotides in various tissues, including heart.

— -This-cluster wasJound to be.selectively_expressed-in heart for -the. following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 9.7; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 3.7; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 5.30E-14.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscle. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 9.7, which clearly supports specific expression in heart tissue.

As noted above, cluster Z30117 features 47 segment(s), which were listed in Table 6168 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z30117_PEA_l_node_0 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6170 below describes the starting and ending position of this segment on each transcript.

Table 6170 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_5 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6171 below describes the starting and ending position of this segment on each transcript.

Table 6171 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4. Segment cluster Z30117_PEA_l_node_7 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6172 below describes the starting and ending position of this segment on each transcript.

Table 6172 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1 JP4.

Segment cluster Z30117_PEA_l_node_9 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6173 below describes the starting and ending position of this segment on each transcript.

Table 6173 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_19 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6174 below describes the starting and ending position of this segment on each transcript.

Table 6174 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1JP4. Segment cluster Z30117_PEA_l_node_21 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6175 below describes the starting and ending position of this segment on each transcript.

Table 6175 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_23 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6176 below describes the starting and ending position of this segment on each transcript.

Table 6176 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_25 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6177 below describes the starting and ending position of this segment on each transcript.

Table 6177 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4. Segment cluster Z30117JPEA_l_node_32 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6178 below describes the starting and ending position of this segment on each transcript.

Table 6178 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_34 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6179 below describes the starting and ending position of this segment on each transcript.

Table 6179 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_36 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6180 below describes the starting and ending position of this segment on each transcript.

Table 6180 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4. Segment cluster Z30117_PEA_l_node_38 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117JPEA_1_T9. Table 6181 below describes the starting and ending position of this segment on each transcript.

Table 6181 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117JPEA_1JP4.

Segment cluster Z30117_PEA_l_node_43 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6182 below describes the starting and ending position of this segment on each transcript.

Table 6182 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_47 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6183 below describes the starting and ending position of this segment on each transcript.

Table 6183 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117JPEA_1_P4. Segment cluster Z30117_PEA_l_node_54 according to the present invention is supported by 17 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6184 below describes the starting and ending position of this segment on each transcript.

Table 6184 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_56 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6185 below describes the starting and ending position of this segment on each transcript.

Table 6185 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_62 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z3O117_PEA_1_T11. Table 6186 below describes the starting and ending position of this segment on each transcript.

Table 6186 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P11. Segment cluster Z30117_PEA_l_node_64 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117JPEA_1 _T12. Table 6187 below describes the starting and ending position of this segment on each transcript.

Table 6187 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_l_P12.

Segment cluster Z30117_PEA_l_node_72 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA__l_T13 and Z30117J^>EA_l_T15. Table 6188 below describes the starting and ending position of this segment on each transcript. Table 6188 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_l_P13 and Z30117_PEA_l_P15.

Segment cluster Z30117_PEA_l_node_79 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9, Z30117_PEA_1_T11, Z30117_PEA_1_T12, Z30117_PEA_1_T13 and Z30117_PEA_1_T15. Table 6189 below describes the starting and ending position of this segment on each transcript. Table 6189 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_1_P15. This segment can also be found in the following protein(s): Z30117_PEA_1_P4, Z30117_PEA_1_P11, Z30117_PEA_1_P12 and

Z30117_PEA_1_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z30117_PEA_l_node_82 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6190 below describes the starting and ending position of this segment on each transcript.

-Table 61-90— Segment-loeation on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_86 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T16. Table 6191 below describes the starting and ending position of this segment on each transcript.

Table 6191 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_1_P15.

Segment cluster Z30117_PEA_l_node_93 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z3O117JPEA_1_T11, Z30117_PEA_l_T12, Z30117_PEA_l_T13, Z30117_PEA_l_T15 and Z30117_PEA_l_T16. Table 6192 below describes the starting and ending position of this segment on each transcript.

Table 6192 - Segment location on transcripts

This segment can be found in the following protein(s): Z3O117_PEA_1_P11, -Z301-17- PEA-I j;Pl-2_rZ30117_PEA-1-P13 and Z30117_PEA-1_P15. —

Segment cluster Z30117_PEA_l_node_95 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6193 below describes the starting and ending position of this segment on each transcript.

Table 6193 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_l_P4. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z30117_PEA_l_node_2 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6194 below describes the starting and ending position of this segment on each transcript.

Table 6194 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node 11 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can^~Be^~fόund iriTEeTdllowmpranscript(s): Z30117JPEA^~lj;T9:TablFei951)elόw^~describes the^" starting and ending position of this segment on each transcript.

Table 6195 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_15 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6196 below describes the starting and ending position of this segment on each transcript.

Table 6196 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_17 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6197 below describes the starting and ending position of this segment on each transcript.

Table 6197 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_27 according to the present invention is supported ^~by^~lTlibfaries. The number of libraries was determined asTpfevioϋsly^" described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6198 below describes the starting and ending position of this segment on each transcript.

Table 6198 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_29 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6199 below describes the starting and ending position of this segment on each transcript.

Table 6199 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_1 jnode_30 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6200 below describes the starting and ending position of this segment on each transcript.

Table 6200 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_40 according to the present invention is supported byT3^~li5faries7 TKe number of libraries^~was^~ 3etermϊrϊed^"as^"p:r eviόusly ^"descfibed7This se grnent can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6201 below describes the starting and ending position of this segment on each transcript.

Table 6201 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4.

Segment cluster Z30117_PEA_l_node_41 according to the present invention is supported by 14 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6202 below describes the starting and ending position of this segment on each transcript.

Table 6202 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117JPEA_1_P4.

Segment cluster Z30117JPEA_l_node_45 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6203 below describes the starting and ending position of this segment on each transcript.

Table 6203 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_49 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6204 below describes the starting and ending position of this segment on each transcript.

Table 6204 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_50 according to the present invention can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6205 below describes the starting and ending position of this segment on each transcript.

Table 6205 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_52 according to the present invention is supported by 13 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6206 below describes the starting and ending position of this segment on each transcript.

Table 6206 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_58 according to the present invention is supported by^~2inrbraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9. Table 6207 below describes the starting and ending position of this segment on each transcript.

Table 6207 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117JPEA_l_P4.

Segment cluster Z30117_PEA_l_node_60 according to the present invention is supported by 22 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9. Table 6208 below describes the starting and ending position of this segment on each transcript.

Table 6208 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_1_P4.

Segment cluster Z30117_PEA_l_node_66 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9, Z3O117_PEA_1_T11 and Z30117JPEA_1_T12. Table 6209 below describes the starting and ending position of this segment on each transcript.

Table 6209 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_l_P12. This segment can also be found in the following protein(s): Z30117_PEA_1_P4 and Z30117_PEA_1_P11, since it is in the coding region for the corresponding transcript.

Segment cluster Z30117_PEA_l_node_68 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117JPEA_1_T9, Z30117_PEA__1_T11 and Z30117_PEA_1_T12. Table 6210 below describes the starting and ending position of this segment on each transcript.

Table 6210 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_1_P12. This segment can also be found in the following protein(s): Z30117_PEA_l_P4 and Z30117JPEAJJPIl, since it is in the coding region for the corresponding transcript.

Segment cluster Z30117JPEA_l_node_70 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9, Z3O117JPEA_1_T11 and Z30117_PEA_l_T12. Table 6211 below describes the starting and ending position of this segment on each transcript.

Table 6211 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117_PEA_l_P4, Z30117 PEA 1 PI l and Z30117 PEA 1 P12.

Segment cluster Z30117_PEA_l_node_74 according to the present invention is supported by 40 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T9, Z30117_PEA_1_T11, Z30117_PEA_l_T12, Z30117_PEA_l_T13 and Z30117_PEA_l_T15. Table 6212 below describes the starting and ending position of this segment on each transcript.

Table 6212 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_1_P15. This segment can also be found in the following protein(s): Z30117_PEA_1_P4, Z30117_PEA_1_P11, Z30117_PEA_1_P12 and

Z30117JPEA_1_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z30117_PEA_l_node_81 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_l_T9, Z30117_PEA_l_Tl l, Z30117JPEA_1_T12 and Z30117_PEA_1__T13. Table 6213 below describes the starting and ending position of this segment on each transcrip t.

Table 6213 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117JPEA_l_P4, Z3O117_PEA_1_P11, Z30117_PEA_l_P12 and Z30117_PEA_l_P13.

Segment cluster Z30117_PEA_l_node_83 according to the present invention can be found in the following transcript(s): Z30117_PEA_l_T9, Z3O117JPEA_1_T11, Z30117J^>EA_1_T12, Z30117_PEA_1_T13 and Z30117_PEA_1_T15. Table 6214 below describes the starting and ending position of this segment on each transcript.

Table 6214 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117J⁵EA_l_P4 and Z30117_PEA_l_P15. This segment can also be found in the following protein(s): Z30117_PEA_1_P11, Z30117_PEA_1_P12 and Z30117_PEA_l_P13, since it is in the coding region for the corresponding transcript.

Segment cluster Z30117_PEA_l_node_87 according to the present invention is supported by 48 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_ 1_T9, Z30117_PEA_1_T11,

Z30117_PEA_1_T12, Z30117_PEA_1_T13, Z30117_PEA_1_T15 and Z30117_PEA_1_T16. Table 6215 below describes the starting and ending position of this segment on each transcript.

Table 6215 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z30117_PEA_l_P4. This segment can also be found in the following protein(s): Z3O117_PEA_1_P11, Z30117_PEA_l_P12, Z30117J^>EA_l_P13 and Z30117_PEA_l_P15, since it is in the coding region for the corresponding transcript. Segment cluster Z30117_PEA_l_node_92 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z30117_PEA_1_T11, Z30117_PEA_1_T12, Z30117_PEA_1_T13, Z30117_PEA_1_T15 and Z30117_PEA_ 1_T16. Table 6216 below describes the starting and ending position of this segment on each transcript.

Table 6216 - Segment location on transcripts

This segment can be found in the following protein(s): Z30117JPEA_1_P11, Z30117_PEA_l_P12, Z30117_PEA_l_P13 and Z30117_PEA_l_P15.

DESCRIPTION FOR CLUSTER H38064

Cluster H38064 features 4 transcript(s) and 46 segment (s) of interest, the names for which are given in Tables 6217 and 6218, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6219.

Table 6217 - Transcripts of interest

Transcript Name

H38064 PEA 1 T19

H38064 PEA 1 T20

H38064 PEA 1 T21

H38064 PEA 1 T32

Table 6218 - Segments of interest

Segment Name

H38064 PEA 1 node 7

H38064 PEA 1 node 21

H38064 PEA 1 node 44 Table 6219 - Proteins of interest

These sequences are variants of the known protein Ubiquitin-like 1 activating enzyme ElA (SwissProt accession identifier SAE1_HUMAN; known also according to the synonyms SUMO-I activating enzyme subunit 1), referred to herein as the previously known protein.

Protein Ubiquitin-like 1 activating enzyme ElA is known or believed to have the following function(s): The dimeric enzyme acts as a UBLl El ligase. It mediates ATP- dependent activation of UBLl and formation of a thiolester with a conserved cysteine residue on SAE2. The sequence for protein Ubiquitin-like 1 activating enzyme El A is given at the end of the application, as "Ubiquitin-like 1 activating enzyme ElA amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6220.

Table 6220 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: protein ubiquitylation, which are annotation(s) related to Biological Process; ubiquitin activating enzyme; protein C-terminus binding; enzyme activator; ubiquitin- like conjugating enzyme; ligase, which are annotation(s) related to Molecular Function; and nucleus, which are annotation(s) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster H38064 features 46 segment(s), which were listed in Table 6218 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster H38064_PEA_l_node_7 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T20. Table 6221 below describes the starting and ending position of this segment on each transcript.

Table 6221 - Segment location on transcripts

Transcript name Segment Segment - starting position ending position

H38064 PEA 1 T20 95 329

This segment can be found in a non- coding region of transcripts) that are related to the following protein(s): H38064_PEA_l_P2.

Segment cluster H38064JPEA_l_node_21 according to the present invention is supported by 93 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20, H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6222 below describes the starting and ending position of this segment on each transcript.

Table 6222 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P2, H38064_PEA_l_P30 and H38064_PEA_l_P36.

Segment cluster H38064_PEA__l_node_44 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T32. Table 6223 below describes the starting and ending position of this segment on each transcript.

Table 6223 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P36.

Segment cluster H38064_PEA_l_node_57 according to the present invention is supported by 73 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6224 below describes the starting and ending position of this segment on each transcript.

Table 6224 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P30. This segment can also be found in the following protein(s): H38O64_PEA_1JP2, since it is in the coding region for the corresponding transcript.

Segment cluster H38064_PEA_l_node_81 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38O64JPEA_1_T21. Table 6225 below describes the starting and ending position of this segment on each transcript.

Table 6225 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_91 according to the present invention is supported by 45 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6226 below describes the starting and ending position of this segment on each transcript.

Table 6226 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_ l_P2 and H38064_PEA_1_P30. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster H38064_PEA_l_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19. Table 6227 below describes the starting and ending position of this segment on each transcript. Table 6227 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA__l_P2.

Segment ^"cluster H380^"64_PEA^~ΪInode^~4 according toTKTpresent invention is supported^" by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T20. Table 6228 below describes the starting and ending position of this segment on each transcript.

Table 6228 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2.

Segment cluster H38064_PEA_l_node_9 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6229 below describes the starting and ending position of this segment on each transcript.

Table 6229 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P30 and H38064_PEA_l_P36.

Segment cluster H38064_PEA_l_node_10 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T21 and H38064JPEA_l _T32. Table 6230 below describes the starting and ending position of this segment on each transcript.

Table 6230 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P30 and H38064 PEA 1 P36.

Segment cluster H38064_PEA_l_node_l 1 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T21 and H38064JPEA_l_T32. Table 6231 below describes the starting and ending position of this segment on each transcript. Table 6231 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P30 and H38064_PEAJ_P36.

Segment cluster H38064_PEA_l_node_12 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6232 below describes the starting and ending position of this segment on each transcript.

Table 6232 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P30 and

H38064 PEA 1 P36.

Segment cluster H38064_PEA_l_node_13 according to the present invention can be -found-in-the-following -transcript(s)÷-H38064_PEA_-tT21-and-H38064^P-EA₌l-T32. -Table ■ 6233 below describes the starting and ending position of this segment on each transcript. Table 6233 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P30 and H38064_PEA_l_P36.

Segment cluster H38064_PEA_l_node_ 16 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19. Table 6234 below describes the starting and ending position of this segment on each transcript. Table 6234 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2.

Segment cluster H38064_PEA_l_node_18 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20, H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6235 below describes the starting and ending position of this segment on each transcript.

Table 6235 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2. This segment can also be found in the following protein(s): H38064_PEA_ l_P30 and H38064_PEA_l_P36, since it is in the coding region for the corresponding transcript.

Segment cluster H38064_PEA_l_node_19 according to the present invention is supported by 89 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20, H38064JPEA_l_T21 and H38064_PEA_l_T32. Table 6236 below describes the starting and ending position of this segment on each transcript.

Table 6236 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P2, H38O64_PEA_1JP3O and H38064_PEA_l_P36.

Segment cluster H38064_PEA_l_node_25 according to the present invention is supported by 81 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_1_T20, H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6237 below describes the starting and ending position of this segment on each transcript.

Table 6237 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P2, H38064 PEA 1 P30 and H38064 PEA 1 P36.

Segment cluster H38064_PEA_l_node_26 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20, H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6238 below describes the starting and ending position of this segment on each transcript.

Table 6238 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l JP2, H38064_PEA_l_P30 and H38064JPEAJJP36.

Segment cluster H38064_PEA_l_node_27 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20, H38064JPEA_l_T21 and H38064_PEA_l_T32. Table 6239 below describes the starting and ending position of this segment on each transcript.

Table 6239 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P2, H38064 PEA 1 P30 and H38064 PEA 1 P36.

Segment cluster H38064_PEA_l_node_28 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20, H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6240 below desciibes the starting and ending position of this segment on each transcript. Table 6240 - Segment location on transcripts

H38064 PEA 1 T32 606 638

This segment can be found in the following protein(s): H38064_PEA_l_P2, H38064_PEA_l_P30 and H38064_PEA_l_P36.

Segment cluster H38064_PEA_l_node_30 according to the present invention is supported by 74 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20, H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6241 below describes the starting and ending position of this segment on each transcript. Table 6241 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P2, _

H38064 PEA 1 P30 and H38064 PEA 1 P36.

Segment cluster H38064JPEA_l_node_32 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064JPEA_l_T20, H38064_PEA_l_T21 and H38064_PEA_l_T32. Table 6242 below describes the starting and ending position of this segment on each transcript. Table 6242 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_PEA_l_P2, H38064 PEA 1 P30 and H38064 PEA 1 P36.

Segment cluster H38064_PEA_l_node_46 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064JPEA_l_T21. Table 6243 below describes the starting and ending position of this segment on each transcript.

Table 6243 - Segment location on transcripts

This segment can be found in the following protein(s): H38064_JPEA_l_P30.

Segment cluster H38064_PEA_l_node_61 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6244 below describes the starting and ending position of this segment on each transcript.

Table 6244 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P30. This segment can also be found in the following protein(s): H38064_PEA_l_P2, since it is in the coding region for the corresponding transcript.

Segment cluster H38064_PEA_l_node_62 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38O64_PEA_1_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6245 below describes the starting and ending position of this segment on each transcript.

Table 6245 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P30. This segment can also be found in the following protein(s): H38064JPEA 1 P2, since it is in the coding region for the corresponding transcript.

Segment cluster H38064_PEA_l_node_69 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_1_T20 and H38064JPEA_l_T21. Table 6246 below describes the starting and ending position of this segment on each transcript. Table 6246 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P30. This segment can also be found in the following protein(s): H38064_PEA_l_P2, since it is in the coding region for the corresponding transcript.

Segment cluster H38064_PEA_l_node_70 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6247 below describes the starting and ending position of this segment on each transcript.

Table 6247 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l JP30. This segment can also be found in the following protein(s): H38064_PEA_l_P2, since it is in the coding region for the corresponding transcript.

Segment cluster H38064_PEA_l_node_71 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6248 below describes the starting and ending position of this segment on each transcript. Table 6248 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064JPEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_72 according to the present invention is supported by 61 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6249 below describes the starting and ending position of this segment on each transcript.

Table 6249 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_73 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6250 below describes the starting and ending position of this segment on each transcript.

Table 6250 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_ l_node_74 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064 JPEA_1_T21. Table 6251 below describes the starting and ending position of this segment on each transcript.

Table 6251 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the followingprotein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_75 according to the present invention can be found in the following transcript(s): H38064_PEA_ l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6252 below describes the starting and ending position of this segment on each transcript.

Table 6252 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38O64_PEA_1JP2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_76 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6253 below describes the starting and ending position of this segment on each transcript.

Table 6253 - Segment location on transcripts

This segment can be found in a non-coding region of transcπpt(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_77 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064JPEA_l_T21. Table 6254 below describes the starting and ending position of this segment on each transcript. Table 6254 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node__78 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064JPEA_l_T21. Table 6255 below describes the starting and ending position of this segment on each transcript.

Table 6255 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064JPEA_l_P2 and H38064_PEA_l_P30. Segment cluster H38064JPEA_l_node_79 according to the present invention is supported by 57 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6256 below describes the starting and ending position of this segment on each transcript.

Table 6256 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l jnode_80 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6257 below describes the starting and ending position of this segment on each transcript. Table 6257 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064JPEA_l_P30.

Segment cluster H38064_PEA_l_node_82 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6258 below describes the starting and ending position of this segment on each transcript. Table 6258 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_83 according to the present invention is supported by 42 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6259 below describes the starting and ending position of this segment on each transcript.

Table 6259 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_84 according to the present invention is supported by 38 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064JPEA_l_T21. Table 6260 below describes the starting and ending position of this segment on each transcript.

Table 6260 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_85 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6261 below describes the starting and ending position of this segment on each transcript.

Table 6261 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064JPEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_86 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l__T20 and H38064_PEA_l_T21. Table 6262 below describes the starting and ending position of this segment on each transcript.

Table 6262 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_87 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6263 below describes the starting and ending position of this segment on each transcript.

Table 6263 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_88 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6264 below describes the starting and ending position of this segment on each transcript.

Table 6264 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

Segment cluster H38064_PEA_l_node_89 according to the present invention can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6265 below describes the starting and ending position of this segment on each transcript.

Table 6265 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064JPEAJ_P30.

Segment cluster H38064_PEA_l_node_90 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): H38064_PEA_l_T19, H38064_PEA_l_T20 and H38064_PEA_l_T21. Table 6266 below describes the starting and ending position of this segment on each transcript.

-Table-6266 - Segjnent-loeation on-transcripts— _ — - __ _~ _ .__

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): H38064_PEA_l_P2 and H38064_PEA_l_P30.

DESCRIPTION FOR CLUSTER HSLDHAR Cluster HSLDHAR features 18 transcript(s) and 40 segment(s) of interest, the names for which are given in Tables 6267 and 6268, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6269.

Table 6267 - Transcripts of interest

Transcript Name

HSLDHAR PEA 3 TO

HSLDHAR PEA 3 Tl

HSLDHAR PEA 3 _T2

HSLDHAR PEA 3 T3

HSLDHAR PEA 3 T4

HSLDHAR PEA 3 T5

HSLDHAR PEA 3 T7

HSLDHAR PEA 3 TI l

HSLDHAR PEA 3 T13

HSLDHAR PEA 3 T19

HSLDHAR PEA 3 T20

HSLDHAR PEA 3 T21

HSLDHAR PEA 3 T22

HSLDHAR PEA 3 T25

HSLDHAR PEA 3 T28

HSLDHAR PEA 3 T29

HSLDHAR PEA^" 3 134

HSLDHAR PEA 3 T37

Table 6268 - Segments of interest

Segment Name

HSLDHAR PEA 3 node 0

HSLDHAR PEA 3 node 2

HSLDHAR PEA 3 node 4

HSLDHAR PEA 3 node 5

HSLDHAR PEA _3_ node 7

HSLDHAR PEA 3 node 12

HSLDHAR PEA 3 node 17

HSLDHAR PEA 3 node 20

HSLDHAR PEA 3 node 21

HSLDHAR PEA 3 node 25

HSLDHAR PEA 3 node 38

HSLDHAR PEA 3 node 41

HSLDHAR PEA 3 node 49

HSLDHAR PEA 3 node 59 HSLDHAR PEA 3 node 60

HSLDHAR PEA 3 node 1

HSLDHAR PEA 3 node 15

HSLDHAR PEA 3 node 16

HSLDHAR PEA 3 node 22

HSLDHAR PEA 3 node 23

HSLDHAR PEA 3 node 26

HSLDHAR PEA 3 node 27

HSLDHAR PEA 3 node 28

HSLDHAR PEA 3 node 29

HSLDHAR PEA 3 node 30

HSLDHAR PEA 3 node 33 .

HSLDHAR PEA 3 node 34

HSLDHAR PEA 3 node 35

HSLDHAR PEA 3 node 37

HSLDHAR PEA 3 node 42

HSLDHAR PEA 3 node 47

HSLDHAR PEA 3 node 48

HSLDHAR PEA 3 node 50

HSLDHAR PEA 3 node 51

HSLDHAR PEA 3 node 52

HSLDHAR PEA 3 node 53

HSLDHAR PEA 3 node 54

HSLDHAR PEA 3 node 55

HSLDHAR PEA 3 node 57

HSLDHAR PEA 3 node 58

Table 6269 - Proteins of interest

These sequences are variants of the known protein L- lactate dehydrogenase A chain (SwissProt accession identifier LDHAJHUMAN; known also according to the synonyms EC 1.1.1.27; LDH-A; LDH muscle subunit; LDH-M), referred to herein as the previously known protein.

The sequence for protein L- lactate dehydrogenase A chain is given at the end of the application, as "L- lactate dehydrogenase A chain amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6270.

Table 6270 - Amino acid mutations for Known Protein

Protein L- lactate dehydrogenase A chain localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: L- lactate dehydrogenase, which are annotation(s) related to Molecular Function; and cytosol, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HSLDHAR can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 147 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 147 and Table 6271. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: a mixture of malignant tumors from different tissues, ovarian carcinoma and gastric carcinoma.

Table 6271 - Normal tissue distribution

Table 6272 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSLDHAR features 40 segment(s), which were listed in Table 6268 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSLDHARJPEA_3_node_0 according to the present invention is supported by 160 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3 _T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHARJPEA_3_T37. Table 6273 below describes the starting and ending position of this segment on each transcript.

Table 6273 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P11, HSLDHARJPEAJ3JP14, HSLDHAR_PEA_3_P15, HSLDHAR_PEA_3_P19 and HSLDHAR_PEA_3_P22.

Segment cluster HSLDHAR_PEA_3_node_2 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHARJPEA 3 T3 and HSLDHAR_PEA_3_T4. Table 6274 below describes the starting and ending position of this segment on each transcript.

Table 6274 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2 and HSLDHAR_PEA_3_P27.

Segment cluster HSLDHAR_PEA_3_node_4 according to the present invention is supported by 18 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T2. Table 6275 below describes the starting and ending position of this segment on each transcript.

Table 6275 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the -following protein(s): HSLDHARJ^>EA_3_P27. — - — _.

Segment cluster HSLDHAR_PEA_3_node_5 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T2, HSLDHAR_PEA__3_T4 and H8LDHAR_PEA_3_T5. Table 6276 below describes the starting and ending position of this segment on each transcript.

Table 6276 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P27. Segment cluster HSLDHAR_PEA_3_node_7 according to the present invention is supported by 240 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1 , HSLDHAR_PEA_3_T2, HSLDHARJPEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDH AR_PEA_3_T7, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHARJ^>EA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T25, HSLDHARJPEA_3_T28, HSLDHARJPEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6277 below describes the starting and ending position of this segment on each transcript.

Table 6277 - Segment location on transcripts

This segment can be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR__PEA_3_P8, HSLDHAR_PEA_3_P11 ,

HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15, HSLDHARJ^>EA_3_P19 and HSLDHAR PEA 3 P22. Segment cluster HSLDHAR_PEA_3_node_12 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T11. Table 6278 below describes the starting and ending position of this segment on each transcript.

Table 6278 - Segment location on transcripts

This segment can be found in the following protein(s): HSLDHAR_PEA_3_P4.

Segment cluster HSLDHAR_PEA_3_node_17 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T13 and HSLDHAR_PEA_3_T37. Table 6279 below describes the starting and ending position of this segment on each transcript.

Table 6279 - Segment location on transcripts

This segment can be found in the following protein(s): HSLDHAR_PEA_3_P28 and HSLDHAR PEA 3 P22.

Segment cluster HSLDHAR_PEA_3_node_20 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T13 and HSLDHAR_PEA_3_T37. Table 6280 below describes the starting and ending position of this segment on each transcript.

Table 6280 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28 and HSLDHAR_PEA_3_P22.

Segment cluster HSLDHAR_PEA_3_node_21 according to the present invention is supported by 335 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHARJPEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDH AR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_ T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_ T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_ T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6281 below describes the starting and ending position of this segment on each transcript.

-Table- 6281— Segment-location on transcripts — — —

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHARJPEA_3 J^>28 and HSLDHAR_PEA_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHARJPEA_3_P4, HSLDH AR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P 15 and HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_25 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T22. Table 6282 below describes the starting and ending position of this segment on each transcript.

Table 6282 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P6.

Segment cluster HSLDHAR_PEA_3_node_38 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T34 and

HSLDHAR_PEA_3_T37. Table 6283 below describes the starting and ending position of this segment on each transcript.

Table 6283 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHARJPEAJ3JP22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDH ARJPE A_3_node_41 according to the present invention is supported by 321 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR _PEA_3_T1, HSLDHARJPEA _3_T2, HSLDHAR JPE A_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR _PEA_3_T11, HSLDHARJPEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR J^>EA_3_T20, HSLDHAR_JPEA_3_T21 and HSLDHAR_PEA_3_T22. Table 6284 below describes the starting and ending position of this segment on each transcript.

Table 6284 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28 and HSLDHAR_PEA_3_P29. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8 and HSLDHAR_PEA_3_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_49 according to the present invention is supported by 270 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHARJPEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6285 below describes the starting and ending position of this segment on each transcript.

Table 6285 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7 and HSLDHAR_PEA_3_P11. This segment can also be found in the following protein(s): HSLDHARJPEA 3 P2, HSLDHARJPEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P14 and HSLDHAR_PEA_3_P15, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA__3_node_59 according to the present invention is supported by 238 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6286 below describes the starting and ending position of this segment on each transcript. Table 6286 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2, HSLDHARJPEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3JP28, HSLDHARJPEA 3JP29, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR JPEA_3_P11, HSLDHAR_PEA_3_P14 and HSLDHAR_PEA_3_P15.

Segment cluster HSLDHAR_PEA_3_node_60 according to the present invention is supported by 105 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHARJΕA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6287 below describes the starting and ending position of this segment on each transcript.

Table 6287 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3JP7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3JP6, HSLDHAR_PEA_3_P11, HSLDHARJPEAJ3JP14 and HSLDHAR_PEA_3_P15.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSLDH AR_PEA_3_node_l according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4 and HSLDHAR_PEA_3_T7. Table 6288 below describes the starting and ending position of this segment on each transcript.

Table 6288 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2 and HSLDHAR_PEA_3_P27.

Segment cluster HSLDHAR_PEA_3_node_15 according to the present invention is supported by 231 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDH AR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDH AR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13₅ HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHARJPEA_3_T37. Table 6289 below describes the starting and ending position of this segment on each transcript.

Table 6289 - Segment location on transcripts

This segment can be found in the following protein(s): HSLDHAR PEA 3 P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15, HSLDHAR_PEA_3_P19 and HSLDHAR PEA 3 P22.

Segment cluster HSLDHAR_PEA_3_node_16 according to the present invention is supported by 235 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEAJ3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHARJPEAJ _T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6290 below describes the starting and ending position of this segment on each transcript.

Table 6290 - Segment location on transcripts

This segment can be found in the following protein(s): HSLDH AR PEA 3JP2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15, HSLDHAR_PEA_3_P19 and HSLDHAR PEA 3 P22.

Segment cluster HSLDHAR_PEA_3_node_22 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA__3_T5, HSLDHARJPEA_3_T7, HSLDHARJPEAJ_Tl l, HSLDHARJPEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6291 below describes the starting and ending position of this segment on each transcript.

Table 6291 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29 and HSLDHAR PEA 3 P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHARJPEA 3JP11, HSLDHARJPEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_23 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR _PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHARJPEA_3_T37. Table 6292 below describes the starting and ending position of this segment on each transcript.

Table 6292 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29 and HSLDHAR_PEA_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHARJPEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHARJPEAJJPll, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_26 according to the present invention is supported by 345 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHARJPEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3 _T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDH ARJPE A_3_T37. Table 6293 below describes the starting and ending position of this segment on each transcript.

Table 6293 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHARJPEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P6 and HSLDH ARJPE A_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHARJPEA_3_P27; HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3JP11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHARJ³EA 3 Pl 9, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_27 according to the present invention is supported by 384 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDH AR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6294 below describes the starting and ending position of this segment on each transcript.

Table 6294 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P6 and HSLDHAR_PEA_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHARJPEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_28 according to the present invention can be found in the following transcript(s): HSLDH ARJPEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHARJPEA_3_T5, HSLDHARJPEA_3_T7, HSLDH AR_PEA_3_T11, HSLDHAR J^>EA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_ T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6295 below describes the starting and ending position of this segment on each transcript.

Table 6295 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3JP29, HSLDHARJPEA_3_P6 and HSLDHARJPEA_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHARJPEA_3_P4, HSLDHAR_PEA_3_P7, H8LDHAR_PEA_3 JP8, HSLDHARJPEA_3JP11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHARJPEA 3JP19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node__29 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDH AR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHARJ^>EA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHARJPEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHARJPEA 3 T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6296 below describes the starting and ending position of this segment on each transcript.

Table 6296 - Segment location on transcripts

HSLDHAR PEA 3 T37 2046 2054

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR JPEA_3J^>28, HSLDHARJPEA_3_P29 and HSLDHAR_PEA_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDH AR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR J^>EA_3JP6, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_30 according to the present invention is supported by 403 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDH AR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHARJPEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6297 below describes the starting and ending position of this segment on each transcript.

Table 6297 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29 and HSLDHAR_PEA_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3J^>7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P11, HSLDHAR_JPEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHAR_PEA_3JP19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_33 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, H8LDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6298 below describes the starting and ending position of this segment on each transcript. Table 6298 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29 and HSLDHAR_PEA_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_34 according to the present invention is supported by 381 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDH AR_PEA_3_T0, HSLDHARJPEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7,

HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA__3_T37. Table 6299 below describes the starting and ending position of this segment on each transcript.

Table 6299 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29 and HSLDHARJPEA 3JP22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14, HSLDHARJPEAJJP15 and HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_35 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDH AR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDH AR_PEA_3_T3, HSLDHAR J^>EA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHARJPEA_3_T29, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6300 below describes the starting and ending position of this segment on each transcript.

Table 6300 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29 and HSLDHAR_PEA_3_P22. This segment can also be found in the following protein(s): HSLDHARJPEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14, HSLDHAR_PEA_3_P15 and HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_37 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1 , HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHARJPEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28, HSLDHAR_PEA_3_T34 and HSLDHAR_PEA_3_T37. Table 6301 below describes the starting and ending position of this segment on each transcript.

Table 6301 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29 and HSLDHAR_PEA_3_P22. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14 and HSLDHAR_PEA_3_P19, since it is in the coding region for the corresponding transcript. Segment cluster HSLDHAR_PEA_3_node_42 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T20. Table 6302 below describes the starting and ending position of this segment on each transcript.

Table 6302 - Segment location on transcripts

This segment can be found in the following protein(s): HSLDHARJPEA 3JP7.

Segment cluster HSLDHAR_PEA_3_node_47 according to the present invention is supported by 255 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDH AR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3 _T4, HSLDHAR_PEA_3_T5, HSLDHARJPEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHARJPEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22 and HSLDHAR_PEA_3_T25. Table 6303 below describes the starting and ending position of this segment on each transcript.

Table 6303 - Segment location on transcripts

HSLDHAR PEA 3 T25 987 1046

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28 and HSLDHAR_PEA_3_P29. This segment can also be found in the following protein(s): HSLDH ARJPEA_3JP2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P7, HSLDHARJPEA_3_P8, HSLDHAR_PEA_3_P6 and HSLDHARJPEA 3JP11, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_48 according to the present invention is supported by 254 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDH AR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHARJPEA_3_T13, HSLDHAR_PEA_3_T19,

HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHARJPEA_3_T22 and HSLDHAR_PEA_3_T25. Table 6304 below describes the starting and ending position of this segment on each transcript.

Table 6304 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P28, HSLDHARJPEA_3_P29, HSLDHAR_PEA_3_P7 and HSLDHAR_PEA_3_P11. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P8 and HSLDHARJPEA_3_P6, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_50 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEAJ_T3, HSLDHAR JΕA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHARJPEA_3_T21 , HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25,

HSLDHARJPEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6305 below describes the starting and ending position of this segment on each transcript.

Table 6305 - Segment location on transcripts

I HSLDHAR PEA 3 T29 | 1098 ! i 1103 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHARJPEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3 J^>6, HSLDHARJPEA_3_P11 and HSLDHAR_PEA_3_P14. This segment can also be found in the following protein(s): HSLDHAR_PEA_3_P15, since it is in the coding region for the corresponding transcript.

Segment cluster HSLDHAR_PEA_3_node_51 according to the present invention is supported by 264 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7,

HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHARJPEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6306 below describes the starting and ending position of this segment on each transcript. Table 6306 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHARJPEA_3_P2, HSLDHAR_PEA_3JP27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, H8LDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6,

HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14 and HSLDHAR_PEA_3_P15.

Segment cluster HSLDHAR_PEA_3_node_52 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6307 below describes the starting and ending position of this segment on each transcript.

Table 6307 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3JP11, HSLDHARJPEA_3_P14 and HSLDHAR_PEA_3_P15.

Segment cluster H8LDHAR_PEA_3_node_53 according to the present invention can be found in the following transcript(s): HSLDHARJPEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHARJPEA 3 T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6308 below describes the starting and ending position of this segment on each transcript.

Table 6308 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHARJPEA_3_P2, HSLDHARJPEA 3JP27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR PE AJJP 8, HSLDHAR_PEA_3_P6,

HSLDH AR_PEA_3_P11, HSLDHAR_PEA_3_P14 and HSLDHAR_PEA_3_P15.

Segment cluster HSLDHAR_PEA_3_node_54 according to the present invention is supported by 276 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6309 below describes the starting and ending position of this segment on each transcript.

Table 6309 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDH AR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHARJPEA_3JP4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3JP8, HSLDHAR_PEA_3_P6, HSLDHARJPEA_3 JPl 1 , HSLDHAR_PEA_3 JP14 and HSLDHAR_PEA_3_P15.

Segment cluster HSLDHAR_PEA_3_node_55 according to the present invention is supported by 269 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1 , HSLDHAR_PEA_3_T2, HSLDHAR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR_PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDH AR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEAJ_T28 and HSLDHAR_PEA_3_T29. Table 6310 below describes the starting and ending position of this segment on each transcript.

Table 6310 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P11₃ HSLDHAR_PEA_3 J^>14 and HSLDHAR_PEA__3_P15.

Segment cluster HS LDHAR_PEA_3_node_57 according to the present invention is supported by 265 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSLDHAR_PEA_3_T0, H8LDHARJPEA_3_T1, HSLDHAR_PEA_3_T2, HSLDH AR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDH AR_PEA_3_T5, HSLDHAR_PEA_3_T7, HSLDHAR _PEA_3_T11, HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6311 below describes the starting and ending position of this segment on each transcript.

Table 6311 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHARJPEA_3JP4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHARJPEA_3_P8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14 and HSLDHAR_PEA_3_P15.

Segment cluster HSLDHAR_PEA_3_node_58 according to the present invention can be found in the following transcript(s): HSLDHAR_PEA_3_T0, HSLDHAR_PEA_3_T1, HSLDHAR_PEA_3_T2, HSLDH AR_PEA_3_T3, HSLDHAR_PEA_3_T4, HSLDHAR_PEA_3_T5, HSLDHARJPEA_3_T7, HSLDHAR _PEA_3_T11 , HSLDHAR_PEA_3_T13, HSLDHAR_PEA_3_T19, HSLDHAR_PEA_3_T20, HSLDHAR_PEA_3_T21, HSLDHAR_PEA_3_T22, HSLDHAR_PEA_3_T25, HSLDHAR_PEA_3_T28 and HSLDHAR_PEA_3_T29. Table 6312 below describes the starting and ending position of this segment on each transcript. Table 6312 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSLDHAR_PEA_3_P2, HSLDHAR_PEA_3_P27, HSLDHAR_PEA_3_P4, HSLDHAR_PEA_3_P28, HSLDHAR_PEA_3_P29, HSLDHAR_PEA_3_P7, HSLDHAR_PEA_3JP8, HSLDHAR_PEA_3_P6, HSLDHAR_PEA_3_P11, HSLDHAR_PEA_3_P14 and HSLDHAR_PEA_3_P15.

DESCRIPTION FOR CLUSTER HSPRO204

Cluster HSPRO204 features 2 transcript(s) and 16 segment(s) of interest, the names for which are given in Tables 6313 and 6314, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6315.

Table 6313 - Transa ipts of interest

Transcript Name

HSPRO204 PEA 1 T17

HSPRO204 PEA 1 T22

Table 6314 - Segments of interest

Segment Name

HSPRO204 PEA 1 node 2

HSPRO204 PEA 1 node 20

HSPRO204 PEA 1 node 40

HSPRO204 PEA 1 node 41

HSPRO204 PEA 1 node 0

HSPRO204 PEA 1 node 22

HSPRO204 PEA 1 node 23

HSPRO204 PEA 1 node 24

HSPRO204_ PEA 1 node _25

HSPRO204 PEA 1 node 26

HSPRO204 PEA 1 node 30

HSPRO204 PEA 1 node 31

HSPRO204 PEA 1 node 32

HSPRO204 PEA 1 node 33

HSPRO204 PEA 1 node 34

HSPRO204 PEA 1 node 39 Table 6315 - Proteins of interest

These sequences are variants of the known protein Prolactin precursor (SwissProt accession identifier PRL_HUMAN; known also according to the synonyms PRL), referred to herein as the previously known protein.

Protein Prolactin precursor is known or believed to have the following function(s): Prolactin acts primarily on the mammary gland by promoting lactation. The sequence for protein Prolactin precursor is given at the end of the application, as "Prolactin precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6316.

Table 6316 - Amino acid mutations for Known Protein

Protein Prolactin precursor localization is believed to be Secreted.

The previously known protein also has the following indication(s) and/or potential therapeutic use(s): Cancer; Immunodeficiency; Vaccine adjunct. It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Natural killer cell stimulant; T cell stimulant. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Anticancer; Immunostimulant.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: cell surface receptor linked signal transduction; hemocyte development; pregnancy; lactation; cell proliferation, which are annotation(s) related to Biological Process; prolactin receptor ligand; hormone, which are annotation(s) related to Molecular Function; and extracellular space; soluble fraction, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster HSPRO204 features 16 segment(s), which were listed in Table 6314 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSPRO204_PEA_l_node_2 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPRO204_PEA_ l_T22. Table 6317 below describes the starting and ending position of this segment on each transcript.

Table 6317 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster HSPRO204_PEA_ l_node_20 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6318 below describes the starting and ending position of this segment on each transcript.

Table 6318 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_l_node_40 according to the present invention is supported by 71 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcripts): HSPRO204JPEA_ l_T17. Table 6319 below describes the starting and ending position of this segment on each transcript.

Table 6319 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_JP16.

Segment cluster HSPRO204JPEA_l_node_41 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6320 below describes the starting and ending position of this segment on each transcript.

Table 6320 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSPRO204JPEAJJP16. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster H8PRO204_PEA_l_node_0 according to the present invention is supported by 15 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPRO204_PEA_l_T22. Table 6321 below describes the starting and ending position of this segment on each transcript.

Table 6321 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSPRO204JPEA_l_node_22 according to the present invention can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6322 below describes the starting and ending position of this segment on each transcript.

Table 6322 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_l_node_23 according to the present invention is supported by 68 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcriρt(s): HSPRO204_PEA_l_T17. Table 6323 below describes the starting and ending position of this segment on each transcript.

Table 6323 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204JPEA_l_P16.

Segment cluster HSPRO204_PEA_l jnode_24 according to the present invention can be found in the following transcript(s): HSPRO204_PEA_l _T17. Table 6324 below describes the starting and ending position of this segment on each transcript.

Table 6324 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_ l_node_25 according to the present invention can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6325 below describes the starting and ending position of this segment on each transcript.

Table 6325 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_l_node_26 according to the present invention can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6326 below describes the starting and ending position of this segment on each transcript.

Table 6326 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l _P16.

Segment cluster HSPRO204_PEA_l_node_30 according to the present invention can be found in the following transcript(s): HSPRO204_PEA_l _T17. Table 6327 below describes the starting and ending position of this segment on each transcript.

Table 6327 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_l_node_31 according to the present invention is supported by 67 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6328 below describes the starting and ending position of this segment on each transcript. Table 6328 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_l_node_32 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6329 below describes the starting and ending position of this segment on each transcript.

Table 6329 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_l_node_33 according to the present invention can be found in the following transcript(s): HSPRO204JPEA_l_T17. Table 6330 below describes the starting and ending position of this segment on each transcript.

Table 6330 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_l_node_34 according to the present invention is supported by 65 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6331 below describes the starting and ending position of this segment on each transcript.

Table 6331 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA_l_P16.

Segment cluster HSPRO204_PEA_l_node_39 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPRO204_PEA_l_T17. Table 6332 below describes the starting and ending position of this segment on each transcript.

Table 6332 - Segment location on transcripts

This segment can be found in the following protein(s): HSPRO204_PEA__l_P16.

DESCRIPTION FOR CLUSTER HSPSTI

Cluster HSPSTI features 3 transcript(s) and 12 segment(s) of interest, the names for which are given in Tables 6333 and 6334, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6335.

Table 6333 - Transcripts of interest

Transcript Name

HSPSTI PEA 1 T5

HSPSTI PEA 1 T6

HSPSTI PEA 1 T7

Table 6334 - Segments of interest

Segment Name

HSPSTI PEA 1 node 6

HSPSTI PEA 1 node 11

HSPSTI PEA 1 node 17

HSPSTI PEA 1 node 18

HSPSTI_. _PEA_ 1 node _0

HSPSTI PEA 1 node 12

HSPSTI PEA 1 node 14

HSPSTI PEA 1 node 15

HSPSTI PEA 1 node 16

HSPSTI PEA 1 node 21

HSPSTI PEA 1 node 22

HSPSTI PEA 1 node 23

Table 6335 - Proteins of interest

These sequences are variants of the known protein Pancreatic secretory trypsin inhibitor precursor (SwissProt accession identifier IPK1_HUMAN; known also according to the synonyms Tumor- associated trypsin inhibitor; TATI; Serine protease inhibitor Kazal- type 1), referred to herein as the previously known protein.

Protein Pancreatic secretory trypsin inhibitor precursor is known or believed to have the following function(s): This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. The sequence for protein Pancreatic secretory trypsin inhibitor precursor is given at the end of the application, as "Pancreatic secretory trypsin inhibitor precursor amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6336.

Table 6336 - Amino acid mutations for Known Protein

Protein Pancreatic secretory trypsin inhibitor precursor localization is believed to be Secreted.

It has been investigated for clinical/therapeutic use in humans, for example as a target for an antibody or small molecule, and/or as a direct therapeutic; available information related to these investigations is as follows. Potential pharmaceutically related or therapeutically related activity or activities of the previously known protein are as follows: Trypsin inhibitor. A therapeutic role for a protein represented by the cluster has been predicted. The cluster was assigned this field because there was information in the drug database or the public databases (e.g., described herein above) that this protein, or part thereof, is used or can be used for a potential therapeutic indication: Alimentary/Metabolic; GI inflammatory/bowel disorders. The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: proteinase inhibitor; serine protease inhibitor, which are annotation(s) related to Molecular Function.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster HSPSTI features 12 segment(s), which were listed in Table 6334 above and for which the sequence(s) are given at the end of the application. These segmeπt(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSPSTI_PEA_l_node_6 according to the present invention is supported by 80 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTI_PEA_1_T5 and HSPSTI_PEA_1_T6. Table 6337 below describes the starting and ending position of this segment on each transcript.

Table 6337 - Segment location on transcripts

This segment can be found in the following protein(s): HSPSTI_PEA_1_P4 and

HSPSTI_PEA_1_P5.

Segment cluster HSPSTI_PEA_l_node_l 1 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTI_PEA_1_T7. Table 6338 below describes the starting and ending position of this segment on each transcript. Table 6338 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSPSTI_PEA_l_node_17 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTI_PEA_1_T5. Table 6339 below describes the starting and ending position of this segment on each transcript.

Table 6339 - Segment location on transcripts

This segment can be found in the following protein(s): HSPSTI_PEA_1 JP4.

Segment cluster HSPSTI_PEA_l_node_18 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTI_PEA_1_T5 and HSPSTI_PEA_1_T6. Table 6340 below describes the starting and ending position of this segment on each transcript.

Table 6340 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSPSTI_PEA_1_P4. This segment can also be found in the following protein(s): HSPSTI_PEA_1_P5, since it is in the coding region for the corresponding transcript. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSPSTI_PEA_l_node_0 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTI_PEA_1_T5 and HSPSTI_PEA_1_T6. Table 6341 below describes the starting and ending position of this segment on each transcript.

Table 6341 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSPSTI_PEA_1_P4 and HSPSTI_PEA_1_P5.

Segment cluster HSPSTI_PEA_l_node_12 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTI_PEA_1_T5, HSPSTI_PEA_1_T6 and HSPSTI_PEA_1_T7. Table 6342 below describes the starting and ending position of this segment on each transcript.

Table 6342 - Segment location on transcripts

This segment can be found in the following protein(s): HSPSTI_PEA_1_P4 and HSPSTI PEA 1 P5. Segment cluster HSPSTIJPEA_l_node_14 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTI_PEA_1_T5, HSPSTI_PEA_1_T6 and HSPSTI_PEA_1_T7. Table 6343 below describes the starting and ending position of this segment on each transcript.

Table 6343 - Segment location on transcripts

This segment can be found in the following protein(s): HSPSTI PEA 1JP4 and HSPSTI PEA 1 P5.

Segment cluster HSPSTI_PEA_l_node_15 according to the present invention can be found in the following transcript(s): HSPSTI_PEA_1_T5, HSPSTI_PEA_1_T6 and HSPSTI_PEA_1_T7. Table 6344 below describes the starting and ending position of this segment on each transcript.

Table 6344 - Segment location on transcripts

This segment can be found in the following protein(s): HSPSTI_PEA_1_P4 and HSPSTI_PEA_1_P5.

Segment cluster HSPSTI_PEA_l_node_16 according to the present invention can be found in the following transcript(s): HSPSTI_PEA_1_T5, HSPSTI_PEA_1_T6 and HSPSTI_PEA_1_T7. Table 6345 below describes the starting and ending position of this segment on each transcript.

Table 6345 - Segment location on transcripts

This segment can be found in the following protein(s): HSPSTI_PEA_1_P4 and HSPSTI PEA 1 P5.

Segment cluster HSPSTI_PEA_l_node_21 according to the present invention is supported by 66 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTI_PEA_1_T7. Table 6346 below describes the starting and ending position of this segment on each transcript.

Table 6346 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster HSPSTI_PEA_l_node_22 according to the present invention can be found in the following transcript(s): HSPSTI_PEA_1_T7. Table 6347 below describes the starting and ending position of this segment on each transcript.

Table 6347 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster HSPSTI_PEA_l_node_23 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSPSTIJPEA_1_T7. Table 6348 below describes the starting and ending position of this segment on each transcript.

Table 6348 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

DESCRIPTION FOR CLUSTER HSUDGM

Cluster HSUDGM features 1 transcript(s) and 9 segment(s) of interest, the names for which are given in Tables 6349 and 6350, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6351.

Table 6349 - Transcripts of interest

Transcript Name

HSUDGM PEA 1 T2

Table 6350 - Segments of interest

Segment Name

HSUDGM PEA 1 node 0

HSUDGM PEA 1 node 1

HSUDGM PEA 1 node 3

HSUDGM PEA_ 1 node A

HSUDGM PEA 1 node 5

HSUDGM PEA 1 node 6

HSUDGM PEA 1 node 7

HSUDGM PEA 1 node 8 HSUDGM PEA 1 node 2

Table 6351 - Proteins of interest

These sequences are variants of the known protein Uracil- DNA glycosylase 2 (SwissProt accession identifier UNG2_HUMAN; known also according to the synonyms EC 3.2.2.-; UDG 2), referred to herein as the previously known protein.

Protein Uracil- DNA glycosylase 2 is known or believed to have the following function(s): Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. The sequence for protein Uracil- DNA glycosylase 2 is given at the end of the application, as "Uracil- DNA glycosylase 2 amino acid sequence". Protein Uracil- DNA glycosylase 2 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: carbohydrate metabolism; base-excision repair, which are annotation(s) related to Biological Process; uracil- DNA glycosylase; hydrolase, acting on glycosyl bonds, which are annotation(s) related to Molecular Function; and nucleus, which are annotations) related to Cellular Component. The GO assignment relies on information from one or more of the SwissProt/TremBl

Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster HSUDGM can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 148 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million). Overall, the following results were obtained as shown with regard to the histograms in Figure 148 and Table 6352. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 6352 - Normal tissue distribution

Table 6353 - P values and ratios for expression in cancerous tissue

As noted above, cluster HSUDGM features 9 segment(s), which were listed in Table 6350 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster HSUDGM_PEA_l_node_0 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGM_PEA_1_T2. Table 6354 below describes the starting and ending position of this segment on each transcript. Table 6354 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSUDGM_PEA_ 1_P4.

Segment cluster HSUDGM_PEA_l_node_l according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGM_PEA_1_T2. Table 6355 below describes the starting and ending position of this segment on each transcript.

Table 6355 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSUDGM_PEA_1 JM.

Segment cluster HSUDGM_PEA_l_node_3 according to the present invention is supported by 21 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGM_PEA_1_T2. Table 6356 below describes the starting and ending position of this segment on each transcript.

Table 6356 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSUDGM_PEA_1_P4.

Segment cluster HSUDGM_PEA_l_node_4 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGM_PEA_1_T2. Table 6357 below describes the starting and ending position of this segment on each transcript.

Table 6357 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSUDGM_PEA_1_P4.

Segment cluster HSUDGM_PEA_l_node_5 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGM_PEA_1_T2. Table 6358 below describes the starting and ending position of this segment on each transcript.

Table 6358 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): HSUDGM_PEA_1 JP4.

Segment cluster HSUDGM_PEA_l_node_6 according to the present invention is supported by 47 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGMJ?EA_1_T2. Table 6359 below describes the starting and ending position of this segment on each transcript.

Table 6359 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSUDGM_PEA_1_P4.

Segment cluster HSUDGMJPEA_l_node_7 according to the present invention is supported by 39 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGM_PEA_1_T2. Table 6360 below describes the starting and ending position of this segment on each transcript.

Table 6360 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSUDGM_PEA_1_P4.

Segment cluster HSUDGM JPEA_l_node_8 according to the present invention is supported by 36 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGM JPEA_1_T2. Table 6361 below describes the starting and ending position of this segment on each transcript.

Table 6361 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): HSUDGM_PEA_1_P4.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster HSUDGM_PEA_l_node_2 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): HSUDGM_PEA_1_T2. Table 6362 below describes the starting and ending position of this segment on each transcript.

Table 6362 - Segment location on transcripts

This segment can be found in the following protein(s): HSUDGM_PEA_1_P4.

DESCRIPTION FOR CLUSTER M62205 Cluster M62205 features 2 transcript(s) and 92 segment(s) of interest, the names for which are given in Tables 6363 and 6364, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6365.

Table 6363 - Transcripts of interest

Transcript Name

M62205 PEA 1 T3

M62205 PEA 1 T17

Table 6364 - Segments of interest

M62205 PEA 1 node 27

M62205 PEA 1 node 29

M62205 PEA 1 node 30

M62205 PEA 1 node 31

M62205 PEA 1 node 32

M62205 PEA 1 node 36

M62205 PEA 1 node 37

M62205 PEA 1 node 38

M62205 PEA 1 node 39

M62205 PEA 1 node 41

M62205 PEA 1 node 42

M62205 PEA 1 node 43

M62205 PEA 1 node 44

M62205 PEA 1 node 45

M62205 PEA 1 node 46

M62205 PEA 1 node 47

M62205 PEA 1 node 48

M62205 PEA 1 node 50

M62205 PEA 1 node 57

M62205 PEA 1 node 58

M62205 PEA 1 node 59

M62205 PEA 1 node 60

M62205 PEA 1 node 61

M62205 PEA 1 node 63

M62205 PEA 1 node 64

M62205 PEA 1 node 65

M62205 PEA 1 node 66

M62205 PEA 1 node 67

M62205 PEA 1 node 68

M62205 PEA 1 node 69

M62205 PEA 1 node 70

M62205 PEA 1 node 71

M62205 PEA 1 node 72

M62205 PEA 1 node 74

M62205 PEA 1 node 75

M62205 PEA 1 node 77

M62205 PEA 1 node 78

M62205 PEA 1 node 79

M62205 PEA 1 node 80

M62205 PEA 1 node 81

M62205 PEA 1 node _82

M62205 PEA 1 node 83

M62205 PEA 1 node 84

M62205 PEA 1 node 85 M62205 PEA 1 node 86

M62205 PEA 1 node 87

M62205 PEA 1 node 88

M62205 PEA 1 node 89

M62205 PEA 1 node 90

M62205 PEA 1 node 91

M62205 PEA 1 node 92

M62205 PEA 1 node 93

M62205 PEA 1 node 94

M62205. _PEA_ 1_ _node_ 95

M62205 PEA 1 node 96

M62205 PEA 1 node 97

M62205 PEA 1 node 98

M62205 PEA 1 node 99

M62205 PEA 1 node 100

M62205 PEA 1 node 101

M62205 PEA 1 node 102

M62205 PEA 1 node 103

Table 6365 - Proteins of interest

These sequences are variants of the known protein Glial fibrillary acidic protein, astrocyte (SwissProt accession identifier GF APJETUMAN; known also according to the synonyms GFAP), referred to herein as the previously known protein.

Protein Glial fibrillary acidic protein, astrocyte is known or believed to have the following function(s): GFAP, a class-Ill intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. The sequence for protein Glial fibrillary acidic protein, astrocyte is given at the end of the application, as "Glial fibrillary acidic protein, astrocyte amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6366.

Table 6366 - Amino acid mutations for Known Protein

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: structural protein of cytoskeleton, which are annotation(s) related to Molecular Function; and intermediate filament, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

As noted above, cluster M62205 features 92 segment(s), which were listed in Table 6364 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided. Segment cluster M62205_PEA_l_node_4 according to the present invention is supported by 116 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6367 below describes the starting and ending position of this segment on each transcript.

Table 6367 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_40 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6368 below describes the starting and ending position of this segment on each transcript. Table 6368 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_51 according to the present invention is supported by 20 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T17. Table 6369 below describes the starting and ending position of this segment on each transcript.

Table 6369 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205JPEA_l JP40.

Segment cluster M62205_PEA_l_node_52 according to the present invention is supported by 33 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205JPEA_l_T17. Table 6370 below describes the starting and ending position of this segment on each transcript.

Table 6370 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205JPEA_l_P40.

Segment cluster M62205_PEA_l_node_53 according to the present invention is supported by 26 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T17. Table 6371 below describes the starting and ending position of this segment on each transcript.

Table 6371 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_54 according to the present invention is supported by 25 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T17. Table 6372 below describes the starting and ending position of this segment on each transcript.

Table 6372 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_56 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T17. Table 6373 below describes the starting and ending position of this segment on each transcript.

Table 6373 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s) : M62205_PEA_l JP40.

Segment cluster M62205_PEA_l_node_73 according to the present invention is supported by 141 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6374 below describes the starting and ending position of this segment on each transcript.

Table 6374 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205JPEA_l_node_76 according to the present invention is supported by 175 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205JPEA_l_T3 and M62205_PEA_l_T17. Table 6375 below describes the starting and ending position of this segment on each transcript.

Table 6375 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_104 according to the present invention is supported by 92 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6376 below describes the starting and ending position of this segment on each transcript.

Table 6376 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40. According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M62205_PEA_l_node_5 according to the present invention is supported by 117 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6377 below describes the starting and ending position of this segment on each transcript.

Table 6377 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l JP40.

Segment cluster M62205_PEA_l_node_6 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6378 below describes the starting and ending position of this segment on each transcript.

Table 6378 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_7 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6379 below describes the starting and ending position of this segment on each transcript.

Table 6379 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_8 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6380 below describes the starting and ending position of this segment on each transcript.

Table 6380 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_9 according to the present invention is supported by 123 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6381 below describes the starting and ending position of this segment on each transcript.

Table 6381 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_10 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6382 below describes the starting and ending position of this segment on each transcript.

Table 6382 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_l 1 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6383 below describes the starting and ending position of this segment on each transcript.

Table 6383 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_12 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6384 below describes the starting and ending position of this segment on each transcript.

Table 6384 - Segment location on transcripts

This segment can be found in the following protein(s): M62205JPEA_l_P40.

Segment cluster M62205JPEA_l_node_13 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6385 below describes the starting and ending position of this segment on each transcript.

Table 6385 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_14 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA j_T17. Table 6386 below describes the starting and ending position of this segment on each transcript.

Table 6386 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_15 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6387 below describes the starting and ending position of this segment on each transcript.

Table 6387 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_16 according to the present invention is supported by 117 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6388 below describes the starting and ending position of this segment on each transcript.

Table 6388 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_17 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6389 below describes the starting and ending position of this segment on each transcript. Table 6389 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_l 9 according to the present invention is supported by 117 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_ l_T3 and M62205_PEA_l_T17. Table 6390 below describes the starting and ending position of this segment on each transcript.

Table 6390 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40. Segment cluster M62205_PEA_l_node_20 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6391 below describes the starting and ending position of this segment on each transcript.

Table 6391 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_21 according to the present invention can be found in the following transcript(s): M62205JPEA_l_T3 and M62205JPEA_l_T17. Table 6392 below describes the starting and ending position of this segment on each transcript.

Table 6392 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_23 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6393 below describes the starting and ending position of this segment on each transcript.

Table 6393 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l JMO. Segment cluster M62205_PEA_l_node_24 according to the present invention can be found in the following transcript(s): M62205JPEA_l_T3 and M62205_PEA_l_T17. Table 6394 below describes the starting and ending position of this segment on each transcript.

Table 6394 - Segment location on transcripts

This segment can be found in the following protein(s): M62205JPEA_l_P40.

Segment cluster M62205_PEA_l_node_25 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6395 below describes the starting and ending position of this segment on each transcript.

Table 6395 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205 JPEA_l_node_26 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6396 below describes the starting and ending position of this segment on each transcript.

Table 6396 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40. Segment cluster M62205_PEA_l_node_27 according to the present invention is supported by 113 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6397 below describes the starting and ending position of this segment on each transcript.

Table 6397 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205JPEA_l_node_29 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6398 below describes the starting and ending position of this segment on each transcript.

Table 6398 - Segment location on transcripts

This segment can be found in the following protein(s): M62205 _PEA_l_P40.

Segment cluster M62205_PEA_l_node_30 according to the present invention is supported by 122 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6399 below describes the starting and ending position of this segment on each transcript.

Table 6399 - Segment location on transcripts

M62205 PEA 1 Tl 7 677 724

This segment can be found in the following protein(s): M62205JPEA_l_P40.

Segment cluster M62205_PEA_l_node_31 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6400 below describes the starting and ending position of this segment on each transcript.

Table 6400 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_32 according to the present invention is supported by 119 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_ l_T17. Table 6401 below describes the starting and ending position of this segment on each transcript.

Table 6401 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_36 according to the present invention is supported by 111 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6402 below describes the starting and ending position of this segment on each transcript. Table 6402 - Segment location on transcripts

This segment can be found in the following protein(s): M622O5JPEA_1JP4O.

Segment cluster M62205JPEA_l_node_37 according to the present invention can be found in the following transcript(s): M62205_PEA_ l_T3 and M62205_PEA_l_T17. Table 6403 below describes the starting and ending position of this segment on each transcript.

Table 6403 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_38 according to the present invention is supported by 122 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6404 below describes the starting and ending position of this segment on each transcript.

Table 6404 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40. Segment cluster M62205_PEA_l_node_39 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6405 below describes the starting and ending position of this segment on each transcript.

Table 6405 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_41 according to the present invention is supported by 121 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6406 below describes the starting and ending position of this segment on each transcript.

Table 6406 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l JP40.

Segment cluster M62205_PEA_l_node_42 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6407 below describes the starting and ending position of this segment on each transcript. Table 6407 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40. Segment cluster M62205_PEA_l_node_43 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6408 below describes the starting and ending position of this segment on each transcript.

Table 6408 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_44 according to the present invention is supported by 125 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6409 below describes the starting and ending position of this segment on each transcript.

Table 6409 - Segment location on transcripts

This segment can be found in the following protein(s):M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_45 according to the present invention is supported by 133 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and

M62205_PEA_l_T17. Table 6410 below describes the starting and ending position of this segment on each transcript.

Table 6410 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_46 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6411 below describes the starting and ending position of this segment on each transcript.

Table 6411 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_47 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6412 below describes the starting and ending position of this segment on each transcript.

Table 6412 ~ Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l JP40.

Segment cluster M62205_PEA_l_node_48 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6413 below describes the starting and ending position of this segment on each transcript. Table 6413 - Segment location on transcripts

This segment can be found in the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_50 according to the present invention is supported by 144 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6414 below describes the starting and ending position of this segment on each transcript.

Table 6414 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_57 according to the present invention is supported by 134 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6415 below describes the starting and ending position of this segment on each transcript. Table 6415 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_58 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6416 below describes the starting and ending position of this segment on each transcript.

Table 6416 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_59 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6417 below describes the starting and ending position of this segment on each transcript. Table 6417 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_60 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205JPEA_l_T17. Table 6418 below describes the starting and ending position of this segment on each transcript.

Table 6418 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205 _PEA_l_P40.

Segment cluster M62205_PEA_l_node_61 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6419 below describes the starting and ending position of this segment on each transcript.

Table 6419 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205JPEA_l_node_63 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6420 below describes the starting and ending position of this segment on each transcript.

Table 6420 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_64 according to the present invention is supported by 139 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6421 below describes the starting and ending position of this segment on each transcript.

Table 6421 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_65 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l _T17. Table 6422 below describes the starting and ending position of this segment on each transcript.

Table 6422 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_66 according to the present invention is supported by 138 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205JPEA_l_T3 and M62205_PEA_l_T17. Table 6423 below describes the starting and ending position of this segment on each transcript.

Table 6423 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_67 according to the present invention is supported by 128 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6424 below describes the starting and ending position of this segment on each transcript. Table 6424 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205JPEA_l__P40.

Segment cluster M62205_PEA_l_node_68 according to the present invention is supported by 131 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6425 below describes the starting and ending position of this segment on each transcript. Table 6425 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l JP40. Segment cluster M62205_PEA_l_node_69 according to the present invention can be found in the following transcript(s): M62205JPEA_l_T3 and M62205_PEA_l_T17. Table 6426 below describes the starting and ending position of this segment on each transcript.

Table 6426 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205JPEA_l_node_70 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6427 below describes the starting and ending position of this segment on each transcript.

Table 6427 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_71 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205 JΕA_1_T17. Table 6428 below describes the starting and ending position of this segment on each transcript. Table 6428 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following ρrotein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_72 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205JPEA_l__T17. Table 6429 below describes the starting and ending position of this segment on each transcript.

Table 6429 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_ l_node_74 according to the present invention is supported by 130 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205JPEA_l_T3 and M62205_PEA_l_T17. Table 6430 below describes the starting and ending position of this segment on each transcript.

Table 6430 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_75 according to the present invention is supported by 139 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6431 below describes the starting and ending position of this segment on each transcript.

Table 6431 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205JPEA_l_node_77 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6432 below describes the starting and ending position of this segment on each transcript.

Table 6432 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA__l_P40.

Segment cluster M62205_PEA_l_node_78 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6433 below describes the starting and ending position of this segment on each transcript.

Table 6433 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40. Segment cluster M62205_PEA_l_node_79 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6434 below describes the starting and ending position of this segment on each transcript.

Table 6434 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_80 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6435 below describes the starting and ending position of this segment on each transcript.

Table 6435 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205JPEA_l_P40.

Segment cluster M62205_PEA_l_node_81 according to the present invention is supported by 153 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and

M62205_PEA_l_T17. Table 6436 below describes the starting and ending position of this segment on each transcript.

Table 6436 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M622O5_PEA_1JP4O.

Segment cluster M62205_PEA_l_node_82 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6437 below describes the starting and ending position of this segment on each transcript.

Table 6437 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_83 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6438 below describes the starting and ending position of this segment on each transcript.

Table 6438 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_84 according to the present invention is supported by 164 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6439 below describes the starting and ending position of this segment on each transcript.

Table 6439 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205JPEA_l_P40.

Segment cluster M62205_PEA_l_node_85 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205JPEA_l_T17. Table 6440 below describes the starting and ending position of this segment on each transcript.

Table 6440 - Segment location on transcripts

This segment can be found in a non- coding region of transcriρt(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_86 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6441 below describes the starting and ending position of this segment on each transcript. Table 6441 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_87 according to the present invention can be found in the following transcript(s): M62205JPEA_l__T3 and M62205_PEA_l _T17. Table 6442 below describes the starting and ending position of this segment on each transcript.

Table 6442 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_ l_P40.

Segment cluster M62205_PEA_l_node_88 according to the present invention is supported by 179 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205JPEA_l _T3 and M62205_PEA_l_T17. Table 6443 below describes the starting and ending position of this segment on each transcript.

Table 6443 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_ l_P40.

Segment cluster M62205JPEA_l_node_89 according to the present invention is supported by 182 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6444 below describes the starting and ending position of this segment on each transcript.

Table 6444 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205JPEA_l_node_90 according to the present invention is supported by 201 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6445 below describes the starting and ending position of this segment on each transcript.

Table 6445 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_91 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205JPEA_l_T17. Table 6446 below describes the starting and ending position of this segment on each transcript.

Table 6446 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_92 according to the present invention is supported by 194 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6447 below describes the starting and ending position of this segment on each transcript. Table 6447 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l JP40.

Segment cluster M62205_PEA_l_node_93 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205JPEA_l_T17. Table 6448 below describes the starting and ending position of this segment on each transcript.

Table 6448 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_94 according to the present invention is supported by 196 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6449 below describes the starting and ending position of this segment on each transcript.

Table 6449 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_95 according to the present invention can be found in the following transcript(s): M62205JPEA_l_T3 and M62205JPEA_l_T17. Table 6450 below describes the starting and ending position of this segment on each transcript.

Table 6450 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_1_P40.

Segment cluster M62205_PEA_l_node_96 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6451 below describes the starting and ending position of this segment on each transcript.

Table 6451 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M622O5_PEA_1JP4O. Segment cluster M62205_PEA_l_node_97 according to the present invention is supported by 189 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205JPEA_l_T17. Table 6452 below describes the starting and ending position of this segment on each transcript.

Table 6452 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l JP40.

Segment cluster M62205_PEA_l_node_98 according to the present invention is supported by 175 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6453 below describes the starting and ending position of this segment on each transcript.

Table 6453 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_99 according to the present invention is supported by 166 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6454 below describes the starting and ending position of this segment on each transcript.

Table 6454 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_ l_node_100 according to the present invention is supported by 157 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6455 below describes the starting and ending position of this segment on each transcript.

Table 6455 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_l 01 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and

M62205_PEA_l_T17. Table 6456 below describes the starting and ending position of this segment on each transcript.

Table 6456 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_102 according to the present invention can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6457 below describes the starting and ending position of this segment on each transcript.

Table 6457 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40.

Segment cluster M62205_PEA_l_node_103 according to the present invention is supported by 114 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M62205_PEA_l_T3 and M62205_PEA_l_T17. Table 6458 below describes the starting and ending position of this segment on each transcript.

Table 6458 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M62205_PEA_l_P40. DESCRIPTION FOR CLUSTER M78228

Cluster M78228 features 8 transcript(s) and 22 segment(s) of interest, the names for which are given in Tables 6459 and 6460, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6461. Table 6459 - Transcripts of interest

Transcript Name"

M78228 PEA 1 TO

M78228 PEA 1 Tl

M78228 PEA 1 T12

M78228 PEA 1 T15

M78228 PEA 1 T16

M78228 PEA 1 Tl 8

M78228 PEA 1 T24

M78228 PEA 1 T25

Table 6460 - Segments of interest

Segment Name

M78228 PEA 1 node 0

M78228 PEA 1 node 1

M78228 PEA 1 node 6

M78228 PEA 1 node 10

M78228 PEA 1 node 17

M78228 PEA 1 node 19

M78228 PEA 1 node 25

M78228 PEA 1 node 26

M78228 PEA 1 node 29

M78228 PEA 1 node 36

M78228 PEA 1 node 2

M78228 PEA 1 node 12

M78228 PEA 1 node 14

M78228 PEA 1 node 18

M78228 PEA 1 node 20

M78228 PEA 1 node 21 M78228 PEA 1 node 22

M78228 PEA 1 node 23

M78228 PEA 1 node 32

M78228 PEA 1 node 33

M78228 PEA 1 node 34

M78228 PEA 1 node 35

Table 6461 - Proteins of interest

These sequences are variants of the known protein Aspartate aminotransferase, cytoplasmic (SwissProt accession identifier AATC_HUMAN; known also according to the synonyms EC 2.6.1.1; Transaminase A; Glutamate oxaloacetate transaminase- 1), referred to herein as the previously known protein.

The sequence for protein Aspartate aminotransferase, cytoplasmic is given at the end of the application, as "Aspartate aminotransferase, cytoplasmic amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6462.

Table 6462 - Amino acid mutations for Known Protein

Protein Aspartate aminotransferase, cytoplasmic localization is believed to be Cytoplasmic.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: aspartate catabolism, which are annotation(s) related to Biological Process. The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locυslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

The heart- selective diagnostic marker prediction engine provided the following results with regard to cluster M78228. Predictions were made for selective expression of transcripts of this contig in heart tissue, according to the previously described methods. The numbers on the y- axis of Figure 149 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histogram in Figure 149, concerning the number of heart- specific clones in libraries/sequences; as well as with regard to the histogram in Figure 150, concerning the actual expression of oligonucleotides in various tissues, including heart.

This cluster was found to be selectively expressed in heart for the following reasons: in a comparison of the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in non- heart ESTs, which was found to be 2.4; the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle- specific ESTs which was found to be 2.6; and fisher exact test P- values were computed both for library and weighted clone counts to check that the counts are statistically significant, and were found to be 3.70E-04.

One particularly important measure of specificity of expression of a cluster in heart tissue is the previously described comparison of the ratio of expression of the cluster in heart as opposed to muscb. This cluster was found to be specifically expressed in heart as opposed to non-heart ESTs as described above. However, many proteins have been shown to be generally expressed at a higher level in both heart and muscle, which is less desirable. For this cluster, as described above, the ratio of expression of the cluster in heart specific ESTs to the overall expression of the cluster in muscle-specific ESTs which was found to be 2.4, which clearly supports specific expression in heart tissue.

As noted above, cluster M78228 features 22 segment(s), which were listed in Table 6460 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster M78228_PEA_l_node_0 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12 and M78228_PEA_1_T18. Table 6463 below describes the starting and ending position of this segment on each transcript.

Table 6463 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P1, M78228_PEA_1_P8 and M78228_PEA_1_P2.

Segment cluster M78228_PEA_l_node_l according to the present invention is supported by 183 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12 and M78228_PEA_1_T18. Table 6464 below describes the starting and ending position of this segment on each transcript.

Table 6464 - Segment location on transcripts

This segment can be found in the following protein(s): M78228_PEA_1_P1, M78228_PEA_1_P8 and M78228__PEA_1_P2.

Segment cluster M78228_PEA_l_node_6 according to the present invention is supported by 199 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12 and M78228_PEA_1_T18. Table 6465 below describes the starting and ending position of this segment on each transcript.

Table 6465 - Segment location on transcripts

This segment can be found in the following protein(s): M78228_PEA_ 1_P1, M78228 PEA 1 P8 and M78228 PEA 1 P2.

Segment cluster M78228_PEA_l_node_10 according to the present invention is supported by 169 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12 and M78228_PEA_l_T18. Table 6466 below describes the starting and ending position of this segment on each transcript. Table 6466 - Segment location on transcripts

This segment can be found in the following protein(s): M78228_PEA_1_P1, M78228_PEA_1_P8 and M78228_PEA_1_P2.

Segment cluster M78228_PEA_l_node_17 according to the present invention is supported by 19 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_1_T15, M78228_PEA_1_T16, M78228_PEA_1_T24 and M78228_PEA_1_T25. Table 6467 below describes the starting and ending position of this segment on each transcript. Table 6467 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228JPEA_1_P11.

Segment cluster M78228_PEA_l_node_19 according to the present invention is supported by 159 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T15, M78228_PEA_1_T16, M78228_PEA_1_T18, M78228_PEA_J_T24 and M78228_PEA_1_T25. Table 6468 below describes the starting and ending position of this segment on each transcript.

Table 6468 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P11. This segment can also be found in the following protein(s): M78228_PEA_1_P1 and M78228_PEA_1_P2, since it is in the coding region for the corresponding transcript.

Segment cluster M78228JPEA_l_node_25 according to the present invention is supported by 157 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12, M78228_PEA_1_T15, M78228_PEA_1_T16, M78228_PEA_1_T18 and M78228_PEA_1_T24. Table 6469 below describes the starting and ending position of this segment on each transcript.

Table 6469 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcriρt(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P8 and M78228_PEA_1_P2. This segment can also be found in the following protein(s): M78228_PEA_1_P1 and M78228JPEA_1_P11, since it is in the coding region for the corresponding transcript. Segment cluster M78228JPEA_l_node_26 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_1_T18 and M78228JPEA_1_T24. Table 6470 below describes the starting and ending position of this segment on each transcript.

Table 6470 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P2.

Segment cluster M78228_PEA_l_node_29 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_1_T18 and M78228_PEA_1_T24. Table 6471 below describes the starting and ending position of this segment on each transcript.

Table 6471 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P2.

Segment cluster M78228_PEA_l_node_36 according to the present invention is supported by 247 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228JPEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12, M78228_PEA_1_T15 and M78228_PEA_l_T16. Table 6472 below describes the starting and ending position of this segment on each transcript.

Table 6472 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P8. This segment can also be found in the following protein(s): M78228_PEA_1_P1 and M78228_PEA_1_P11, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster M78228_PEA_l_node_2 according to the present invention is supported by 181 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12 and M78228_PEA_l_T18. Table 6473 below describes the starting and ending position of this segment on each transcript.

Table 6473 - Segment location on transcripts

M78228 PEA 1 Tl 8 990 1020

This segment can be found in the following protein(s): M78228_PEA_1_P1, M78228_PEA_1_P8 and M78228_PEA_1_P2.

Segment cluster M78228_PEA_l_node_12 according to the present invention is supported by 168 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228JPEA_1_T1, M78228_PEA_1_T12 and M78228_PEA_1_T18. Table 6474 below describes the starting and ending position of this segment on each transcript.

Table 6474 - Segment location on transcripts

This segment can be found in the following protein(s): M78228_PEA_1_P1, M78228 PEA 1 P8 and M78228 PEA 1 P2.

Segment cluster M78228_PEA_l_node_14 according to the present invention is supported by 156 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12 and M78228_PEA_l_T18. Table 6475 below describes the starting and ending position of this segment on each transcript. Table 6475 - Segment location on transcripts

This segment can be found in the following protein(s): M78228_PEA_1 JPl, M78228 PEA 1 P8 and M78228 PEA 1 P2.

Segment cluster M78228_PEA_l_node_l 8 according to the present invention is supported by 139 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T15, M78228_PEA_1_T16, M78228_PEA_1_T18, M78228_PEA_1_T24 and M78228JPEA_1_T25. Table 6476 below describes the starting and ending position of this segment on each transcript.

Table 6476 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA__1_P11. This segment can also be found in the following protein(s): M78228_PEA_1JP1 and M78228_PEA_1_P2, since it is in the coding region for the corresponding transcript.

Segment cluster M78228_PEA_l_node_20 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_1_T16,

M78228_PEA_1_T18 and M78228_PEA_1_T24. Table 6477 below describes the starting and ending position of this segment on each transcript.

Table 6477 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P11. This segment can also be found in the following protein(s): M78228_PEA_1_P2, since it is in the coding region for the corresponding transcript.

Segment cluster M78228JPEA_l_jiode_21 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T15, M78228_PEA_1_T16, M78228_PEA_1_T18, M78228_PEA_1_T24 and M78228_PEA_1_T25. Table 6478 below describes the starting and ending position of this segment on each transcript.

Table 6478 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P2. This segment can also be found in the following protein(s): M78228_PEA_1_P1 and M78228_PEA_1_P11, since it is in the coding region for the corresponding transcript. Segment cluster M78228_PEA_l_node_22 according to the present invention is supported by 147 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12, M78228JPEA_1_T15, M78228_PEA_1_T16, M78228_PEA_1_T18, M78228_PEA_1_T24 and M78228_PEA_1_T25. Table 6479 below describes the starting and ending position of this segment on each transcript.

Table 6479 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P2. This segment can also be found in the following protein(s): M78228_PEA_1_P1, M78228_PEA_1_P8 and M78228_PEA_1 JPI l, since it is in the coding region for the corresponding transcript.

Segment cluster M78228JPEA_l_node_23 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_1_T25. Table 6480 below describes the starting and ending position of this segment on each transcript.

Table 6480 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein. Segment cluster M78228_PEA_l_node_32 according to the present invention is supported by 144 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12, M78228_PEA_1_T15 and M78228_PEA_l_T16. Table 6481 below describes the starting and ending position of this segment on each transcript.

Table 6481 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P8. This segment can also be found in the following protein(s): M78228_PEA_1__P1 and M78228_PEA_1_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78228JPEA_l_node_33 according to the present invention is supported by 148 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12, M78228_PEA_1_T15 and M78228_PEA_l_T16. Table 6482 below describes the starting and ending position of this segment on each transcript. Table 6482 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P8. This segment can also be found in the following protein(s): M78228_PEA_1_P1 and M78228_PEA_1_P1 1 , since it is in the coding region for the corresponding transcript.

Segment cluster M78228_PEA_l_node_34 according to the present invention is supported by 151 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): M78228_PEA_l_T0,

M78228_PEA_1_T1, M78228_PEA_1_T12, M78228_PEA_1_T15 and M78228_PEA_l_T16. Table 6483 below describes the starting and ending position of this segment on each transcript.

Table 6483 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1_P8. This segment can also be found in the following protein(s): M78228_PEA_1_P1 and M78228_PEA_1_P11, since it is in the coding region for the corresponding transcript.

Segment cluster M78228_PEA_l_node_35 according to the present invention can be found in the following transcript(s): M78228_PEA_l_T0, M78228_PEA_1_T1, M78228_PEA_1_T12, M78228_PEA_1_T15 and M78228_PEA_1_T16. Table 6484 below describes the starting and ending position of this segment on each transcript. Table 6484 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): M78228_PEA_1JP8. This segment can also be found in the following protein(s): M78228_PEA_1_P1 and M78228_PEA_1_P11 , since it is in the coding region for the corresponding transcript.

TCAC

DESCRIPTION FOR CLUSTER R31990

Cluster R31990 features 10 transcript(s) and 38 segment(s) of interest, the names for which are given in Tables 6485 and 6486, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6487.

Table 6485 - Transcripts of interest

Transcript Name

R31990 PEA 1 T2

R31990 PEA 1 T3

R31990 PEA 1 T4

R31990 PEA 1 T6

R31990 PEA 1 TI l

R31990 PEA _1_ _T12

R31990 PEA 1 T14

R31990 PEA 1 T20

R31990 PEA 1 T21 I R31990 PEA 1 T23 I

Table 6486 - Segments of interest

Segment Name

R31990 PEA 1 node 2

R31990 PEA 1 node 4

R31990 PEA 1 node 6

R31990 PEA 1 node 8

R31990 PEA 1 node 9

R31990 PEA 1 node 14

R31990 PEA 1 node 16

R31990 PEA 1 node 19

R31990 PEA 1 node 22

R31990 PEA 1 node 25

R31990 PEA 1 node 34

R31990 PEA 1 node 42

R31990 PEA 1 node 47

R31990 PEA 1 node 49

R31990 PEA 1 node 52

R31990 PEA 1 node 53

R31990 PEA 1 node 54

R31990 PEA 1 node 57

R31990 PEA 1 node 59

R31990 PEA 1 node 60

R31990 PEA 1 node 11

R31990 PEA 1 node 12

R31990 PEA 1 node 17

R31990 PEA 1 node 18

R31990 PEA 1 node 20

R31990 PEA 1 node 21

R31990 PEA 1 node 24

R31990 PEA 1 node 29

R31990. PEA 1 node 33

R31990 PEA 1 node 36

R31990 PEA 1 node 37

R31990 PEA 1 node 39

R31990 PEA 1 node 44

R31990 PEA 1 node 46

R31990 PEA 1 node 50

R31990 PEA 1 node 55

R31990 PEA 1 node 56

R31990 PEA 1 node 58 Table 6487 - Proteins of interest

Cluster R31990 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 151 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 151 and Table 6488. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and a mixture of malignant tumors from different tissues.

Table 6488 - Normal tissue distribution

Table 6489 - P values and ratios for expression in cancerous tissue

As noted above, cluster R31990 features 38 segment(s), which were listed in Table 6486 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster R31990_PEA_l_node_2 according to the present invention is supported by 2 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T4 and R31990JPEA_l_T6. Table 6490 below describes the starting and ending position of this segment on each transcript.

Table 6490 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1_P1 and R31990JPEA_l_P4.

Segment cluster R31990_PEA_l_node_4 according to the present invention is supported by 30 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990JPEAJJT20, R31990_PEA_l_T21 and R31990JPEA_l_T23. Table 6491 below describes the starting and ending position of this segment on each transcript.

Table 6491 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P9, R31990_PEA_l_P10 and R31990_PEA_l_P12.

Segment cluster R31990_PEA_l_node_6 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2. Table 6492 below describes the starting and ending position of this segment on each transcript.

Table 6492 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1_P1.

Segment cluster R31990_PEA_l_node_8 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T3. Table 6493 below describes the starting and ending position of this segment on each transcript.

Table 6493 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s) : R31990_PEA_l_P 1.

Segment cluster R31990_PEA_l_rLθde_9 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T<5, R31990_PEA_l_T20, R31990_PEA_l_T21 and R31990_PEA_l_T23. Table 6494 below describes the starting and ending position of this segment on each transcript.

Table 6494 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P4. This segment can also be found in the following protein(s): R31990_PEA_l_Pl, R31990_PEA_l_P9, R31990_PEA_l_P10 and

R31990_PEA_l_P12, since it is in the coding region for the corresponding transcript.

Segment cluster R31990_PEA_l_node_14 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T12. Table 6495 below describes the starting and ending position of this segment on each transcript.

Table 6495 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P7.

Segment cluster R31990_PEA_l_node_16 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_Tl 1. Table 6496 below describes the starting and ending position of this segment on each transcript.

Table 6496 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P7.

Segment cluster R31990_PEA_l_node_19 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T23. Table 6497 below describes the starting and ending position of this segment on each transcript.

Table 6497 - Segment location on transcripts

This segment can be found in the following protein(s): R31990_PEA_l_P7 and R31990 PEA 1 P12.

Segment cluster R31990 JPEA_l_node_22 according to the present invention is supported by 49 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T23. Table 6498 below describes the starting and ending position of this segment on each transcript.

Table 6498 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P12.

Segment cluster R31990JPEA_l_node_25 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199OJPEA_1_T11, R31990_PEA_l_T12, R31990_PEA_l_T20 and R31990_PEA_l_T21. Table 6499 below describes the starting and ending position of this segment on each transcript.

Table 6499 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P7, R31990_PEA_l_P9 and R31990_PEA_l_P10.

Segment cluster R31990_PEA_l_node_34 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T21. Table 6500 below describes the starting and ending position of this segment on each transcript.

Table 6500 - Segment location on transcripts

This segment can be found in the following protein(s): R31990_PEA_l_P10.

Segment cluster R31990_PEA_l_node_42 according to the present invention is supported by 10 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T20. Table 6501 below describes the starting and ending position of this segment on each transcript.

Table 6501 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1_P1,

R31990_PEA_l_P4, R31990_PEA_l_P7 and R31990_PEA_l_P9.

Segment cluster R31990_PEA_l_node_47 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T20. Table 6502 below describes the starting and ending position of this segment on each transcript.

Table 6502 - Segment location on transcripts

This segment can be found in the following protein(s): R31990_PEA_l_P9.

Segment cluster R31990_PEA_l_node_49 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T14. Table 6503 below describes the starting and ending position of this segment on each transcript.

Table 6503 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P6.

Segment cluster R31990_PEA_l_node_52 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEAJ_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R31990_PEA_l_Tl l, R31990_PEAJ_T12 and R31990_PEA_l_T14. Table 6504 below describes the starting and ending position of this segment on each transcript.

Table 6504 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P6. This segment can also be found in the following protein(s): R3199O_PEA_1JP1, R31990_PEA_l_P4 and R31990_PEA_l_P7, since it is in the coding region for the corresponding transcript.

Segment cluster R31990_PEA_l_node_53 according to the present invention is supported by 77 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990JPEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T14. Table 6505 below describes the starting and ending position of this segment on each transcript.

Table 6505 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4 and R31990_PEA_l_P7. This segment can also be found in the following protein(s): R31990_PEA_l_P6, since it is in the coding region for the corresponding transcript.

Segment cluster R31990_PEA_l_node_54 according to the present invention is supported by 51 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R31990_PEA_l_Tl l, R31990_PEA_l_T12 and R31990_PEA_l_T14. Table 6506 below describes the starting and ending position of this segment on each transcript.

Table 6506 - Segment location on transcripts

This segment can be found in both coding and no n- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4 and R31990_PEA_l_P7. This segment can also be found in the following protein(s): R31990_PEA_l_P6, since it is in the coding region for the corresponding transcript.

Segment cluster R31990_PEA_l_node_57 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199OJPEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T14. Table 6507 below describes the starting and ending position of this segment on each transcript.

Table 6507 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P7 and R31990 PEA 1 P6.

Segment cluster R31990_PEA_l_node_59 according to the present invention is supported by 84 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990JPEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T14. Table 6508 below describes the starting and ending position of this segment on each transcript.

Table 6508 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1JP1, R31990JPEA_l_P4, R31990JPEA_l_P7 and R31990 PEA 1 P6.

Segment cluster R31990_PEA_l_node_60 according to the present invention is supported by 70 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990JPEAJ _T2, R31990JPEAJ_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R31990JPEA_l_Tll, R31990JPEAJ_T12 and R31990JPEAJ_T14. Table 6509 below describes the starting and ending position of this segment on each transcript. Table 6509 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1_P1, R3199O_PEA_1JP4, R31990_PEA_l_P7 and R31990 PEA 1 P6.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster R31990_PEA_l_node_l 1 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T20, R31990_PEA_l_T21 and R31990_PEA_l_T23. Table 6510 below describes the starting and ending position of this segment on each transcript. Table 6510 - Segment location on transcripts

This segment can be found in the following protein(s): R31990JPEA 1 P1, R31990_PEA 1 P9, R31990 PEA 1 P10 and R31990 PEA_1 P12.

Segment cluster R31990_PEA_l_node_l 2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T6. Table 6511 below describes the starting and ending position of this segment on each transcript.

Table 6511 - Segment location on transcripts

This segment can be found in the following protein(s): R31990_PEA_l_P4.

Segment cluster R31990_PEA_l_node_17 according to the present invention is supported by 63 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990JPEA_l_T4, R31990_PEA_l_T6, R31990_PEA_l_Tl l, R31990_PEA_l_T12, R31990JPEA _l_T20, R31990_PEA_l_T21 and R31990_PEA_l_T23. Table 6512 below describes the starting and ending position of this segment on each transcript.

Table 6512 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P7. This segment can also be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P9, R31990_PEA_l_P10 and R31990_PEA_l_P12, since it is in the coding region for the corresponding transcript.

Segment cluster R31990_PEA_l_node_18 according to the present invention can be found in the following transcript(s): R31990__PEA_l_T2, R31990_PEA_l_T3,

R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12, R31990_PEA_l_T20, R31990_PEA_l_T21 and R31990_PEA_l_T23. Table 6513 below describes the starting and ending position of this segment on each transcript.

Table 6513 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P7. This segment can also be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P9, R31990_PEA_l_P10 and R31990_PEA_l_P12, since it is in the coding region for the corresponding transcript.

Segment cluster R31990_PEA_l_node_20 according to the present invention can be found in the following transcript(s): R31990_PEA_l_T2, R3199O_PEA_1_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R31990_PEA_l_Tl l, R31990_PEA_l_T12, R31990_PEA_l_T20, R31990_PEA_l_T21 and R31990_PEA_l_T23. Table 6514 below describes the starting and ending position of this segment on each transcript.

Table 6514 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P12. This segment can also be found in the following protein(s): R3199O_PEA_1_P1 , R31990JPEA_l_P4, R31990JPEA_l JP7, R31990_PEA_l_P9 and R31990_PEA_l_P10, since it is in the coding region for the corresponding transcript.

Segment cluster R31990_PEA_l_node_21 according to the present invention is supported by 62 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R31990JPEA_ljm, R31990_PEA_l_T12, R31990_PEA_l_T20, R31990_PEA_l_T21 and R31990_PEA_l_T23. Table 6515 below describes the starting and ending position of this segment on each transcript.

Table 6515 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P12. This segment can also be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P7, R3199O_PEA_1JP9 and R31990JPEA_l_P10, since it is in the coding region for the corresponding transcript. Segment cluster R31990_PEA_l_node_24 according to the present invention can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990JPEA_l_T4, R31990_PEA_l_T6, R3199OJPEA_1_T1 1, R31990_PEA_l_T12, R31990JPEA_l_T20 and R31990_PEA_l_T21. Table 6516 below describes the starting and ending position of this segment on each transcript.

Table 6516 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P7, R31990_PEA_l_P9 and R31990_PEA_l_P10.

Segment cluster R31990_PEA_l_node_29 according to the present invention is supported by 11 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990 JPEAJ_Tl 2,

R31990_PEA_l_T20 and R31990_PEA_l_T21. Table 6517 below describes the starting and ending position of this segment on each transcript.

Table 6517 - Segment location on transcripts

This segment can be found in the following protein(s): R3199OJPEA_1_P1, R31990JPEAJJP4, R31990_PEA_l_P7, R31990JPEA_l_P9 and R31990JPEAJJP10.

Segment cluster R31990_PEA_l_node_33 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA _1_T11, R31990_PEAJ_T12, R31990_PEA_l_T20 and R31990_PEA_l_T21. Table 6518 below describes the starting and ending position of this segment on each transcript.

Table 6518 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P7, R31990_PEA_l_P9 and R31990_PEA_l_P10.

Segment cluster R31990_PEA_l_node_36 according to the present invention is supported by 7 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T20. Table 6519 below describes the starting and ending position of this segment on each transcript. Table 6519 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P7 and R31990_PEA_l_P9.

Segment cluster R31990_PEA_l_node_37 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T20. Table 6520 below describes the starting and ending position of this segment on each transcript.

Table 6520 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R3199O_PEA_1JP7 and R31990_PEA_l_P9.

Segment cluster R31990JPEA_l_node_39 according to the present invention is supported by 8 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990J^>EA_l_T12 and R31990_PEA_l_T20. Table 6521 below describes the starting and ending position of this segment on each transcript.

Table 6521 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1JP1, R31990_PEA_l_P4, R31990 PEA 1_P7 and R31990 J^>EA_1_P9.

Segment cluster R31990_PEA_l_node_44 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990JPEA_l_T12 and R31990_PEA_ l_T20. Table 6522 below describes the starting and ending position of this segment on each transcript.

Table 6522 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P7 and R31990_PEA_l_P9.

Segment cluster R31990_PEA_l_node_46 according to the present invention is supported by 12 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEAJ_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T20. Table 6523 below describes the starting and ending position of this segment on each transcript.

Table 6523 - Segment location on transcripts

This segment can be found in the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4, R31990_PEA_l_P7 and R31990_PEA_l_P9.

Segment cluster R31990_PEA_l_node_50 according to the present invention is supported by 13 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T14. Table 6524 below describes the starting and ending position of this segment on each transcript.

Table 6524 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_P6. This segment can also be found in the following protein(s): R3199O_PEA_1JP1, R31990_PEA_l_P4 and R31990JPEAJJP7, since it is in the coding region for the corresponding transcript.

Segment cluster R31990_PEA_l_node_55 according to the present invention is supported by 50 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990JPEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l _T14. Table 6525 below describes the starting and ending position of this segment on each transcript.

Table 6525 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1_P1, R31990_PEA_l_P4 and R31990_PEA_l_P7. This segment can also be found in the following protein(s): R31990_PEA_l JP6, since it is in the coding region for the corresponding transcript. Segment cluster R31990_PEA_l_node_56 according to the present invention is supported by 52 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3, R31990_PEA_l_T4, R31990_PEA_l_T6, R3199OJPEA_1_T11, R31990_PEA_l_T12 and R31990_PEA_l_T14. Table 6526 below describes the starting and ending position of this segment on each transcript.

Table 6526 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): R3199O_PEA_1_P1, R31990JPEAJJM, R31990_PEA_l_P7 and R31990 PEA 1 P6.

Segment cluster R31990_PEA_l_node_58 according to the present invention can be found in the following transcript(s): R31990_PEA_l_T2, R31990_PEA_l_T3,

R31990JPEA_l_T4, R31990_PEA_l_T6, R3199O_PEA_1_T11, R31990_PEA_l_T12 and R31990JPEA_l_T14. Table 6527 below describes the starting and ending position of this segment on each transcript.

Table 6527 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): R31990_PEA_l_Pl, R31990_PEA_l_P4, R31990_PEA_l_P7 and R31990 PEA 1 P6.

DESCRIPTION FOR CLUSTER Z39337

Cluster Z39337 features 1 transcript(s) and 8 segment(s) of interest, the names for which are given in Tables 6528 and 6529, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6530.

Table 6528 - Transcripts of interest

Transcript Name

Z39337 PEA 2 PEA 1 T6

Table 6529 - Segments of interest

Segment Name

Z39337 PEA 2 PEA 1 node 2

Z39337 PEA 2 PEA 1 node 15

Z39337 PEA 2 PEA 1 node 18

Z39337 PEA 2 PEA 1 node 21

Z39337 PEA 2 PEA 1 node 22

Z39337 PEA 2 PEA 1 node 3

Z39337 PEA 2 PEA 1 node 6

Z39337 PEA 2 PEA 1 node 14

Table 6530 - Proteins of interest

These sequences are variants of the known protein Kallikrein 6 precursor (SwissProt accession identifier KLK6_HUMAN; known also according to the synonyms EC 3.4.21.-; Protease M; Neurosin; Zyme; SP59), referred to herein as the previously known protein.

The sequence for protein Kallikrein 6 precursor is given at the end of the application, as "Kallikrein 6 precursor amino acid sequence". Protein Kallikrein 6 precursor localization is believed to be Secreted.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: central nervous system development; response to wounding; protein autoprocessing, which are annotation(s) related to Biological Process; chymotrypsin; tissue kallikrein; trypsin; protein binding; hydrolase, which are annotation(s) related to Molecular Function; and extracellular; cytoplasm, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nhn.nih.gov/projects/LocusLink/>.

Cluster Z39337 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 152 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 152 and Table 6531. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors and gastric carcinoma. Table 6531 - Normal tissue distribution

Table 6532 - P values and ratios for expression in cancerous tissue

For this cluster, at least one oligonucleotide was found to demonstrate overexpression of the cluster, although not of at least one transcript/segment as listed below. Microarray (chip) data is also available for this cluster as follows. Various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer, as previously described. The following oligonucleotides were found to hit this cluster but not other segments/transcripts below, shown in Table 6533.

Table 6533 - Oligonucleotides related to this cluster

Z39337 0 9 0 ovanan carcinoma OVA

As noted above, cluster Z39337 features 8 segment(s), which were listed in Table 6529 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z39337_PEA_2_PEA_l_node_2 according to the present invention is supported by 23 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39337_PEA_2_PEA_1_T6. Table 6534 below describes the starting and ending position of this segment on each transcript.

Table 6534 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39337JPEA_2_PEA_1_P13.

Segment cluster Z39337_PEA_2_PEA_l_node_15 according to the present invention is supported by 54 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39337_PEA_2_PEA_1_T6. Table 6535 below describes the starting and ending position of this segment on each transcript.

Table 6535 - Segment location on transcripts

This segment can be found in the following protein(s): Z39337JPEA_2_PEA_1JP13. Segment cluster Z39337_PEA__2_PEA_l_node_18 according to the present invention is supported by 53 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39337_PEA_2_PEA_1_T6. Table 6536 below describes the starting and ending position of this segment on each transcript.

Table 6536 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39337_PEA_2_PEAJ_P13.

Segment cluster Z39337_PEA_2_PEA_l_node_21 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39337_PEA_2JPEA_1_T6. Table 6537 below describes the starting and ending position of this segment on each transcript.

Table 6537 - Segment location on transcripts

This segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z39337_PEA_2_PEA_1_P13.

Segment cluster Z39337_PEA_2_PEA_l_node_22 according to the present invention is supported by 58 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39337_PEA_2_PEA_1_T6. Table 6538 below describes the starting and ending position of this segment on each transcript.

Table 6538 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39337_PEA_2JPEA_1JP13.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z39337_PEA_2_PEA_l_node_3 according to the present invention is supported by 55 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39337_PEA_2_PEA_1_T6. Table 6539 below describes the starting and ending position of this segment on each transcript.

Table 6539 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z39337_PEA_2_PEA_1_P13.

Segment cluster Z39337_PEA_2JPEA_l_node_6 according to the present invention is supported by 56 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z39337_PEA_2_PEA_1_T6. Table 6540 below describes the starting and ending position of this segment on each transcript.

Table 6540 - Segment location on transcripts

This segment can be found in the following protein(s): Z39337_PEA_2_PEA_ 1_P13. Segment cluster Z39337_PEA_2_PEA_l_node_14 according to the present invention is supported by 49 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z39337JPEA_2_PEA_1_T6. Table 6541 below describes the starting and ending position of this segment on each transcript.

Table 6541 - Segment location on transcripts

This segment can be found in the following protein(s): Z39337_PEA_2_PEA_1_P13.

DESCRIPTION FOR CLUSTER Z43749

Cluster Z43749 features 15 transcript(s) and 40 segment(s) of interest, the names for which are given in Tables 6542 and 6543, respectively, the sequences themselves are given at the end of the application. The selected protein variants are given in Table 6544.

Table 6542 - Transcripts of interest

Transcript Name

Z43749_ PEA 1 Tl

Z43749 PEA 1 T3

Z43749 PEA 1 T4

Z43749 PEA 1 T5

Z43749 PEA 1 T6

Z43749 PEA 1 T8

Z43749 PEA 1 T12

Z43749 PEA 1 T16

Z43749 PEA 1 T17

Z43749 PEA 1 T18

Z43749 PEA 1 T22

Z43749 PEA 1 T24 Z43749 PEA 1 T30

Z43749 PEA 1 T31

Z43749 PEA 1 T32

Table 6543 - Segments of interest

Segment Name

Z43749 PEA 1 node 0

Z43749 PEA 1 node 2

Z43749 PEA 1 node 6

Z43749 PEA 1 node 11

Z43749 PEA 1 node 14

Z43749 PEA 1 node 16

Z43749 PEA 1 node 19

Z43749 PEA 1 node 21

Z43749 PEA 1 node 30

Z43749 PEA 1 node 32

Z43749 PEA 1 node 34

Z43749 PEA 1 node 35

Z43749 PEA 1 node 37

Z43749 PEA 1 node 42

Z43749 PEA 1 node 44

Z43749 PEA 1 node 53

Z43749 PEA 1 node 8

Z43749 PEA 1 node 9

Z43749 PEA 1 node 12

Z43749 PEA 1 node 13

Z43749 PEA 1 node 15

Z43749 PEA 1 node 20

Z43749 PEA 1 node 22

Z43749 PEA 1 node 23

Z43749 PEA 1 node 24

Z43749 PEA 1 node 25

Z43749 PEA 1 node 27

Z43749 PEA 1 node 28

Z43749 PEA 1 node 33

Z43749 PEA 1 node 36

Z43749 PEA 1 node 40

Z43749 PEA 1 node 41

Z43749 PEA 1 node 43

Z43749 PEA 1 node 46

Z43749 PEA 1 node 47

Z43749 PEA 1 node 48

Z43749 PEA 1 node 49 Z43749 PEA 1 node 50

Z43749 PEA 1 node 51

Z43749 PEA 1 node 52

Table 6544 - Proteins of interest

These sequences are variants of the known protein Kinesin-like protein KIF22 (SwissProt accession identifier KF22JHUMAN; known also according to the synonyms Kinesin-like DNA- binding protein; Kinesin-like protein 4), referred to herein as the previously known protein.

Protein Kinesin-like protein KIF22 is known or believed to have the following function(s): KINESIN FAMILY THAT IS INVOLVED IN SPINDLE FORMATION AND THE MOVEMENTS OF CHROMOSOMES DURING MITOSIS AND MEIOSIS. BINDS TO MICROTUBULES AND TO DNA. The sequence for protein Kinesin-like protein KIF22 is given at the end of the application, as "Kinesin-like protein KIF22 amino acid sequence". Known polymorphisms for this sequence are as shown in Table 6545.

Table 6545 - Amino acid mutations for Known Protein

1 505 - 513 1 ENHCPTMLR -> RTΪVPQCSG^"

Protein Kinesin-like protein KJF22 localization is believed to be Nuclear.

The following GO Annotation(s) apply to the previously known protein. The following annotation(s) were found: mitosis, which are annotation(s) related to Biological Process; DNA binding; motor; microtubule motor; ATP binding, which are annotation(s) related to Molecular Function; and nucleus; microtubule associated protein, which are annotation(s) related to Cellular Component.

The GO assignment relies on information from one or more of the SwissProt/TremBl Protein knowledgebase, available from <http://www.expasy.ch/sprot/>; or Locuslink, available from <http://www.ncbi.nlm.nih.gov/projects/LocusLink/>.

Cluster Z43749 can be used as a diagnostic marker according to overexpression of transcripts of this cluster in cancer. Expression of such transcripts in normal tissues is also given according to the previously described methods. The term "number" in the left hand column of the table and the numbers on the y-axis of Figure 153 refer to weighted expression of ESTs in each category, as "parts per million" (ratio of the expression of ESTs for a particular cluster to the expression of all ESTs in that category, according to parts per million).

Overall, the following results were obtained as shown with regard to the histograms in Figure 153 and Table 6546. This cluster is overexpressed (at least at a minimum level) in the following pathological conditions: epithelial malignant tumors, a mixture of malignant tumors from different tissues and uterine malignancies.

Table 6546 - Normal tissue distribution

Table 6547 - P values and ratios for expression in cancerous tissue

As noted above, cluster Z43749 features 40 seginent(s), which were listed in Table 6543 above and for which the sequence(s) are given at the end of the application. These segment(s) are portions of nucleic acid sequence(s) which are described herein separately because they are of particular interest. A description of each segment according to the present invention is now provided.

Segment cluster Z43749_PEA_l_node_0 according to the present invention is supported by 101 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1__T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22, Z43749JPEA_1_T24 and Z43749_PEA_1_T31. Table 6548 below describes the starting and ending position of this segment on each transcript.

Table 6548 - Segment location on transcripts

This segment can be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P22, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P26, Z43749_PEA_1JP14, Z43749__PEA_1_P16 and Z43749_PEA_l_P20.

Segment cluster Z43749_PEA_l_node_2 according to the present invention is supported by 1 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T16. Table 6549 below describes the starting and ending position of this segment on each transcript.

Table 6549 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749JPEAJJP21.

Segment cluster Z43749_PEA_l_node_6 according to the present invention is supported by 118 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22, Z43749_PEA_1_T24 and Z43749_PEA_1_T31. Table 6550 below describes the starting and ending position of this segment on each transcript.

Table 6550 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P21. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43149J^>EA_IJ^>22, Z43749JPEA__1_P4, Z43749_PEA_1_P5, Z43749_PEA_1JP6, Z43749_PEA_1_P26, Z43749_PEA_1_P14, Z43749JPEA_1_P16 and Z43749_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_l 1 according to the present invention is supported by 116 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749JPEAJ_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749 JPEA_1_T22 and Z43749_PEA_1_T24. Table 6551 below describes the starting and ending position of this segment on each transcript.

Table 6551 - Segment location on transcripts

I Z43749 PEA 1 T24 | I 1473 I 1621 I

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P21. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P22, Z43749J?EA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEAJ_P26, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_14 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T18. Table 6552 below describes the starting and ending position of this segment on each transcript.

Table 6552 - Segment location on transcripts

This segment can be found in the following protein(s): Z43749_PEA_1_P26.

Segment cluster Z43749_PEA_ l_node_16 according to the present invention is supported by 112 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749JPEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22 and Z43749_PEA_1_T24. Table 6553 below describes the starting and ending position of this segment on each transcript.

Table 6553 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749JPEAJ JP21 and Z43749_PEA_1 JP26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P22, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_19 according to the present invention is supported by 120 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22 and Z43749JPEA_1_T24. Table 6554 below describes the starting and ending position of this segment on each transcript.

Table 6554 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749JPEAJJP2, Z43749_PEA_1_P22, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749J?EA_1JP6, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_21 according to the present invention is supported by 3 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T3. Table 6555 below describes the starting and ending position of this segment on each transcript.

Table 6555 - Segment location on transcripts

This segment can be found in the following protein(s): Z43749_PEA_1_P22.

Segment cluster Z43749_PEA_l_node_30 according to the present invention is supported by 4 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T22 and Z43749JPEA_1_T24. Table 6556 below describes the starting and ending position of this segment on each transcript.

Table 6556 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P16. This segment can also be found in the following protein(s): Z43749_PEA_1_P14, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_32 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_l_T30 and Z43749_PEA_1_T32. Table 6557 below describes the starting and ending position of this segment on each transcript.

Table 6557 - Segment location on transcripts

The previously - described transcripts for these segment(s) do not code for protein.

Segment cluster Z43749_PEA_l_node_34 according to the present invention is supported by 99 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749JPEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA__1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEAJ_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6558 below describes the starting and ending position of this segment on each transcript.

Table 6558 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 6559.

Table 6559 - Oligonucleotides related to this segment

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P22, Z43749_PEA_1_P21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6 and Z43749JPEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_35 according to the present invention is supported by 5 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T4, Z43749_PEA_l_T30 and Z43749_PEA_1_T32. Table 6560 below describes the starting and ending position of this segment on each transcript. Table 6560 - Segment location on transcripts

I Z43749 PEA 1 T32 I 1595 I I 2055 I

This segment can be found in the following protein(s): Z43749JPEA_1_P4.

Segment cluster Z43749_PEA_l_node_37 according to the present invention is supported by 110 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749__PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749JPEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA__l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6561 below describes the starting and ending position of this segment on each transcript.

Table 6561 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P22, Z43749_PEA_1_P4 and Z43749_PEA__1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P21 and Z43749JPEAJJP20, since it is in the coding region for the corresponding transcript. Segment cluster Z43749_PEA_l_node_42 according to the present invention is supported by 43 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T4, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T17, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6562 below describes the starting and ending position of this segment on each transcript.

Table 6562 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 6563.

Table 6563 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P4, Z43749_PEA_1_P6 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, since it is in the coding region for the corresponding transcript. Segment cluster Z43749_PEA_l_node_44 according to the present invention is supported by 69 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749JPEA_1_T1, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749 _PEA_1_T12, Z43749_PEA_1_T17, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6564 below describes the starting and ending position of this segment on each transcript.

Table 6564 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P4, Z43749_PEA_1J^>5, Z43749 PEA 1 P6 and Z43749 PEA 1 P20.

Segment cluster Z43749_PEA_l_node_53 according to the present invention is supported by 161 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6565 below describes the starting and ending position of this segment on each transcript. Table 6565 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P2, Z43749JPEA_1_P22, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P26 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749_PEA_1_P21, since it is in the coding region for the corresponding transcript.

According to an optional embodiment of the present invention, short segments related to the above cluster are also provided. These segments are up to about 120 bp in length, and so are included in a separate description.

Segment cluster Z43749_PEA_l_node_8 according to the present invention is supported by 113 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749JPEAJ _T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22, Z43749_PEA_1_T24 and Z43749_PEA_1_T31. Table 6566 below describes the starting and ending position of this segment on each transcript.

Table 6566 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_ 1_P21. This segment can also be found in the following protein(s): Z43749JPEAJJP2, Z43749_PEA_1_P22, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1JP26, Z43749_PEA_1_P14, Z43749JPEA_1_P16 and Z43749_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_9 according to the present invention is supported by 105 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA__1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22 and Z43749_PEA_1_T24. Table 6567 below describes the starting and ending position of this segment on each transcript.

Table 6567 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P21. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749J^>EA_1_P22, Z43749_PEA_1_P4,

Z43749JPEA_1 JP5, Z43749_PEA_1_P6, Z43749_PEA_1_P26, Z43749_PEA_1_P14 and Z43749_PEA_1JP16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_12 according to the present invention can be found in the following transcript(s): Z43749_PEA_1_T1 , Z43749_PEA_1_T3,

Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22 and Z43749_PEA_1_T24. Table 6568 below describes the starting and ending position of this segment on each transcript. Table 6568 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1JP21. This segment can also be found in the following protein(s): Z43749JPEAJJP2, Z43749_PEA_1_P22, Z43749JPEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P26, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_ l_node_13 according to the present invention can be found in the following transcript(s): Z43749JPEA_1_T18. Table 6569 below describes the starting and ending position of this segment on each transcript.

Table 6569 - Segment location on transcripts

This segment can be found in the following protein(s): Z43749_PEA_1 JP26.

Segment cluster Z43749_PEA_ l_node_15 according to the present invention is supported by 105 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749JPEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_J_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22 and Z43749_PEA_1_T24. Table 6570 below describes the starting and ending position of this segment on each transcript.

Table 6570 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P21 and Z43749_PEA_1 JP26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_ 1_P22,

Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P14 and Z43749_PEA_1 JP16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_20 according to the present invention is supported by 79 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749J^>EA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22 and Z43749_PEA_1_T24. Table 6571 below describes the starting and ending position of this segment on each transcript.

Table 6571 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1JP2, Z43749_PEA_1_P22, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_22 according to the present invention can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3,

Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22 and Z43749_PEA_1_T24. Table 6572 below describes the starting and ending position of this segment on each transcript. Table 6572 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P22, Z43749_PEA_1_P21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_23 according to the present invention is supported by 83 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749JPEA_1_T6, Z43749_PEA_1_T8, Z43749JPEA_1_T12, Z43749_PEA_1_T16, Z43749JPEA_1_T17, Z43749_PEA_1_T18, Z43749JPEA_1_T22 and Z43749JPEAJ_T24. Table 6573 below describes the starting and ending position of this segment on each transcript.

Table 6573 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P22, Z43749_PEA_1_P21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript. Segment cluster Z43749_PEA_l_node_24 according to the present invention is supported by 78 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749JPEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749JPEA_1_T18, Z43749_PEA_1_T22 and Z43749JPEA_1_T24. Table 6574 below describes the starting and ending position of this segment on each transcript.

Table 6574 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P22, Z43749_PEA_1_P21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1JP2, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749J^>EA_1_P6, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_25 according to the present invention can be found in the following transcript(s): Z43749JPEA_1_T1, Z43749_PEA_ 1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8₅ Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18 and Z43749_PEA_1_T22. Table 6575 below describes the starting and ending position of this segment on each transcript.

Table 6575 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P22, Z43749_PEA_1_P21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749JPEA__1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6 and Z43749_PEA_1_P14, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_27 according to the present invention is supported by 88 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8,

Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749JPEA_1_T17, Z43749_PEA_1 _T18 and Z43749_PEA_1_T22. Table 6576 below describes the starting and ending position of this segment on each transcript.

Table 6576 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749JPEA_1_P22, Z43749_PEA_1_P21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6 arri Z43749_PEA_1_P14, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_28 according to the present invention is supported by 81 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_1_T22 and Z43749_PEA_1_T24. Table 6577 below describes the starting and ending position of this segment on each transcript.

Table 6577 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P22, Z43749JPEA_1JP21 and Z43749_PEA_1_P26. This segment can also be found in the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P14 and Z43749_PEA_1_P16, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_33 according to the present invention can be found in the following transcript(s): Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6578 below describes the starting and ending position of this segment on each transcript.

Table 6578 - Segment location on transcripts

This segment can be found in the following protein(s): Z43749_PEA_l_P20.

Segment cluster Z43749_PEA_l_node_36 according to the present invention is supported by 9 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T4, Z43749JPEA_1_T6, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749JPEA_1_T32. Table 6579 below describes the starting and ending position of this segment on each transcript.

Table 6579 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 6580.

Table 6580 - Oligonucleotides related to this segment

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P4. This segment can also be found in the following protein(s): Z43749_PEA_1_P6 and Z43749_PEA_l_P20, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_40 according to the present invention is supported by 109 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749JPEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6581 below describes the starting and ending position of this segment on each transcript.

Table 6581 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749JPEA_1_P22, Z43749_PEA_1_P4, Z43749_PEA_1_P6, Z43749_PEA_1JP26 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749JPEA_1_P2, Z43749_PEAJ_P5 and Z43749_PEA_1_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_41 according to the present invention is supported by 16 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T4, Z43749_PEA_1_T6, Z43749_PEAJ_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T17, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6582 below describes the starting and ending position of this segment on each transcript. Table 6582 - Segment location on transcripts

Z43749 PEA 1 T32 2334 2375

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non- coding region of transcript(s) that are related to the following protein(s): Z43749JPEAJ JP4, Z43749_PEA_1_P6 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749_PEA_1 JP2, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_43 according to the present invention is supported by 41 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749 _PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T17, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6583 below describes the starting and ending position of this segment on each transcript.

Table 6583 - Segment location on transcripts

Microarray (chip) data is also available for this segment as follows. As described above with regard to the cluster itself, various oligonucleotides were tested for being differentially expressed in various disease conditions, particularly cancer. The following oligonucleotides were found to hit this segment, shown in Table 6584. Table 6584 - Oligonucleotides related to this segment

Z43749 0 0 71790 lung malignant tumors LUN

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P2, Z43749JPEA_1_P4, Z43749_PEA_1_P6 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749_PEA_1_P5, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_46 according to the present invention is supported by 209 libraries. The number of libraries was deteπnined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6585 below describes the starting and ending position of this segment on each transcript. Table 6585 - Segment location on transcripts

This segment can be found in both coding and non-coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P22, Z43749JPEA_1_P4, Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P26 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749_PEA_1_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749JPEA_l_node_47 according to the present invention is supported by 203 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749JPEA_1__T1, Z43749JPEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749JPEA_1_T12, Z43749_PEA_1_T16, Z43749JPEA_1_T18, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6586 below describes the starting and ending position of this segment on each transcript.

Table 6586 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P22, Z43749_PEA_1_P4,

Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_FEA_1 JP26 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749_PEA_1_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_48 according to the present invention is supported by 194 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749JPEA_1_T8, Z43749_PEA_1_T12, Z43749JPEA_1_T16, Z43749_PEA_1_T18, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6587 below describes the starting and ending position of this segment on each transcript.

Table 6587 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749__PEA_1_P2, Z43749_PEA_1_P22, Z43749_PEA_1_JP4, Z43749_PEA_1_P5, Z43749JPEAJ JP6, Z43749_PEA_1_P26 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749_PEA_1_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_49 according to the present invention is supported by 24 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T8, Z43749_PEA_1_T12 and Z43749_PEA_1_T32. Table 6588 below describes the starting and ending position of this segment on each transcript.

Table 6588 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P2.

Segment cluster Z43749_PEA_l__node_50 according to the present invention can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749J^>EA_1_T4, Z43749_PEA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749JPEAJ_T16, Z43749_PEA_1_T18, Z43749_PEA_l_T30, Z43749JPEA_1_T31 and Z43749_PEA_1_T32. Table 6589 below describes the starting and ending position of this segment on each transcript.

Table 6589 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P2, Z43749JPEA_1_P22, Z43749_PEA_1_P4,

Z43749_PEA_1_P5, Z43749_PEA_1_P6, Z43749_PEA_1_P26 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749_PEA_1_P21, since it is in the coding region for the corresponding transcript.

Segment cluster Z43749_PEA_l_node_51 according to the present invention is supported by 176 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T1, Z43749_PEA_1_T3, Z43749_PEA_1_T4, Z43749JΕA_1_T5, Z43749_PEA_1_T6, Z43749_PEA_1_T8, Z43749_PEA_1_T12, Z43749_PEA_1_T16, Z43749_PEA_1_T17, Z43749_PEA_1_T18, Z43749_PEA_l_T30, Z43749_PEA_1_T31 and Z43749_PEA_1_T32. Table 6590 below describes the starting and ending position of this segment on each transcript.

Table 6590 - Segment location on transcripts

This segment can be found in both coding and non- coding regions of transcript(s) as follows. The segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749_PEA_1_P2, Z43749_PEA_1_P22, Z43749_PEA_1_P4, Z43749_PEA_1 JP5, Z43749_PEA_1_P6, Z43749_PEA_1_P26 and Z43749_PEA_l_P20. This segment can also be found in the following protein(s): Z43749JPEA_ 1_P21, since it is in the coding region for the corresponding transcript. Segment cluster Z43749_PEA_l_node_52 according to the present invention is supported by 6 libraries. The number of libraries was determined as previously described. This segment can be found in the following transcript(s): Z43749_PEA_1_T12. Table 6591 below describes the starting and ending position of this segment on each transcript.

Table 6591 - Segment location on transcripts

This segment can be found in a non-coding region of transcript(s) that are related to the following protein(s): Z43749JPEA_1_P2.

It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination.

Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims. All publications, patents and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. In addition, citation or identification of any reference in this application shall not be construed as an admission that such reference is available as prior art to the present invention.

Claims

WHAT IS CLAIMED IS:

1. An isolated polynucleotide having a sequence selected from the group according to SEQ ID NOs 869-895, or a polynucleotide at least about 70% identical thereto.

2. An amplicon having a sequence according to HUMCAlXlA seg55.

3. A primer pair, comprising a pair of isolated oligonucleotides capable of amplifying said amplicon of claim 2.

4. The primer pair of claim 3, comprising a pair of isolated oligonucleotides: HUMCAlXlA seg55F and HUMCAlXlA seg55R.

5. A kit for detecting lung cancer, comprising a kit detecting expression of a splice variant according to claim 1.

6. The kit of claim 5, wherein said kit comprises a NAT-based technology.

7. The kit of claim 6, wherein said kit further comprises at least one primer pair capable of selectively hybridizing to a nucleic acid sequence according to claim 1.

8. The kit of claim 5, wherein said kit further comprises at least one oligonucleotide capable of selectively hybridizing to a nucleic acid sequence according to claim 1.

9. A method for detecting lung cancer, comprising detecting expression of a splice variant according to claim 1.

10. The method of claim 9, wherein said detecting expression is performed with a NAT-based technology.