EP1715840A1 - Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof - Google Patents

Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof

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Publication number
EP1715840A1
EP1715840A1 EP05722913A EP05722913A EP1715840A1 EP 1715840 A1 EP1715840 A1 EP 1715840A1 EP 05722913 A EP05722913 A EP 05722913A EP 05722913 A EP05722913 A EP 05722913A EP 1715840 A1 EP1715840 A1 EP 1715840A1
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EP
European Patent Office
Prior art keywords
amino
thieno
furo
methyl
substituent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05722913A
Other languages
German (de)
French (fr)
Other versions
EP1715840B1 (en
Inventor
Bryan Patrick Murphy
Robert Wayne Glenn, Jr.
Mu-Lll Lim
John Michael Gardlik
Stevan David Jones
William David Laidig
John David Shaffer
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Procter and Gamble Co
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Procter and Gamble Co
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Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP1715840A1 publication Critical patent/EP1715840A1/en
Application granted granted Critical
Publication of EP1715840B1 publication Critical patent/EP1715840B1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/10—Preparations for permanently dyeing the hair

Definitions

  • This invention relates to bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms, compositions for the oxidative dyeing of keratin fibers (preferably hair) comprising such compounds, and use thereof.
  • keratin fibers preferably hair
  • BACKGROUND OF THE INVENTION The most extensively used method currently employed to color hair is by an oxidative process that utilizes one or more oxidative hair coloring agents in combination with one or more oxidizing agents. Commonly, a peroxy oxidizing agent is used in combination with one or more developers or couplers, generally small molecules capable of diffusing into hair.
  • a peroxide material such as hydrogen peroxide
  • a wide variety of developers and couplers have been employed in such oxidative hair coloring systems and compositions.
  • additional keratin dyeing compounds that can act as both developers and couplers that safely provide color benefits.
  • This invention also relates to a composition for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and one or more bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms.
  • This invention further relates to a method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.
  • the keratin dyeing compounds of the present invention can act as both a developer and a coupler. It is to be understood that within the scope of this invention, numerous potentially and actually tautomeric compounds are involved.
  • 2-mercaptopyridine (I) exists under known conditions in the pyridine-2-thione tautomer form (II). It is to be understood that when this development refers to a particular structure, all of the reasonable additional tautomeric structures are included. In the art, tautomeric structures are frequently represented by one single structure and the present invention follows this general practice.
  • the present invention relates to bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms.
  • the compounds of the present invention can act as both developers and/or couplers that safely provide color benefits.
  • “comprising” means that other steps and other ingredients which do not affect the end result can be added. This term encompasses the terms "consisting of and “consisting essentially of.
  • compositions and methods/processes of the present invention can comprise, consist of, and consist essentially of the essential elements and limitations of the invention described herein, as well as any of the additional or optional ingredients, components, steps, or limitations described herein. All percentages, parts and ratios are based upon the total weight of the compositions of the present invention, unless otherwise specified. All such weights as they pertain to listed ingredients are based on the active level and, therefore do not include solvents or by-products that may be included in commercially available materials, unless otherwise specified. The term “weight percent” may be denoted as "wt. %" herein.
  • keratin refers to a scleroprotein found in epidermal tissues and modified into hard structures such as horns, hair, and nails.
  • keratinous fibers refers to those found in hair, skin and nails and various animal body parts such as horns, hooves and feathers.
  • hair refers to keratinous fibers on a living, e.g. a person, or non-living body, e.g.
  • keratin dyeing compounds refers to compounds that may be used in the composition to act as developers, couplers, or both, in order to provide color to ketatinous fibers.
  • keratin dyeing composition refers to the composition containing one or more keratin dyeing compounds, including the compounds described herein.
  • Keratin dyeing Compounds The inventive compounds are bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms relating to the following compounds:
  • Y and Z are independently selected from the group consisting of NA 1 , S and O; wherein R 1 , R 2 , R 3 , and R 4 are the same or different and are selected from the group consisting of: (a) C-linked monovalent substituents selected from the group consisting of: (i) substituted or unsubstituted, straight or branched, alkyl, mono- or poly- unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefmic systems, (ii) substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems, and (iii) substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems; wherein said systems of (i), (ii) and (iii) comprise from about 1 to about 10 carbon atoms and from about 0 to about 5 heteroatoms selected from the group consisting of O, S, N, P
  • a , A , and A are monovalent and are independently selected from the group consisting of: H; substituted or unsubstituted, straight or branched, alkyl, mono- or poly-unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefinic systems; substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems; and substituted or unsubstituted, mono-, poly-
  • R 1 , R 2 , R 3 , and R 4 are selected from the group consisting of a hydrogen atom; a halogen atom such as chlorine, bromine or fluorine; an amino substituent, a hydroxyl substituent; a cyano substituent; a Cj-C alkyl substituent; a trifluoromethyl substituent, an alkylamino substituent (e.g., N,N-dimethylamino, N,N- diethylamino, N-methylamino, or N-ethylamino); a hydroxyalkylamino substituent (e.g., N-(hydroxyethyl)amino, N-hydroxymethylamino, N-hydroxypropylarnino, N,N- bis(hydroxyethyl)amino, N-(2,3-dihydroxypropyl)amino or N,N- bis(hydroxypropyl)amino); an acetylamido substituent
  • Rl, R2, R3, or R4 is an amino group, with at least one of the remaining Rl, R2, R3 or R4 substitutent preferably being selected from the group consisting of Amino, hydroxyl, a 3-, 4-, 5-, 6-, or 7- membered heterocycle having at least one nitrogen, oxygen or sulfur atom (e.g., pyridyl, quinolyl, mo ⁇ holyl, furyl, tetrahydrofuryl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, imidazolyl, thiadiazolyl, pyrollidine, piperidine, mo ⁇ holine, piperazine, indoline, hexahydroazepine, aziridine, and azetidine) and being optionally substituted, Alkylamino (linear, branched, or cyclic C1-C5), Dialkylamino (linear, branched, or cyclic C1-
  • substituents are selected from the group consisting of Amino, Hydroxyl, Alkylamino (linear, branched, or cyclic C1-C5), Hydroxyalkylamino (linear, branched, or cyclic C l - C5), Arylamino or substituted arylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, CI -C5 alkylamino), Heteroarylamino or substituted heteroarylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), Arylmethylamino or substituted arylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5
  • the developers and couplers of the present invention can also accommodate nucleofugic leaving groups selected from the group consisting of hydrogen, chlorine, cyano, alkoxy, phenoxy, methylsulfonyoxy, pyridone and pyridazone.
  • the couplers of the present invention are utilized in compositions together with suitable 5-membered ring developers chosen from the following classes: thiophenes, pyrroles, furans, pyrazoles, imidazoles, thiazoles, oxazoles, isothiazoles, or isoxazoles.
  • the couplers of the present invention are utilized in compositions together with pyrazoles.
  • the couplers of the present invention are utilized in compositions together with the following pyrazoles: 1 -methyl- lH-pyrazole-4,5-diamine, 2-(4,5-diamino- lH-pyrazol- l-yl)ethanol, 1 -isopropyl- lH-pyrazole-4,5-diamine, 1 -(4- methylbenzyl)-lH-pyrazole-4,5-diamine, l-(benzyl)-lH-pyrazole-4,5-diamine, l-(4- chlorobenzyl)-lH-pyrazole-4,5-diamine and l-Hydroxyethyl-4,5-diaminopyrazole sulphate.
  • the couplers of the present invention are utilized in compositions together with l-methyl-lH-pyrazole-4,5-diamine; 1 -Hydroxy ethyl-4, 5- diaminopyrazole sulphate; and 2-(4,5-diamino-lH-pyrazol-l-yl)ethanol. While not being bound to theory, such combinations enable the achievement of desired more hypsochromic colors (e.g., yellow) relative to conventional combinations of developers and couplers.
  • Preferred developers and couplers include the following compounds with two or three heteroatoms: A.
  • Bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two heteroatoms are selected from the group consisting of Pyrrolopyrroles, Furopyrroles, Thienopyrroles, Furofurans, Thienofurans, Thienothiophenes, and substitutions thereof.
  • Pyrrolopyrroles a.
  • Preferred Developers are selected from the group consisting of 1,4-dihydro- pyrrolo[3,2-b]pyrrole-2,5-diamine, N'2'-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5- diamine, N'2'-ethyl- 1 ,4-dihydro-pyrrolo[3,2-b]pyrroIe-2,5-diamine, 2-(5-amino- 1 ,4- dihydro-pyrrolo[3 ,2-b]pyrrol-2-ylamino)-ethanol, 2-[(5-Amino- 1 ,4-dihydro-pyrrolo[3 ,2- b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-l,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ylamine, l-methyl-l-l
  • Especially preferred developers of the present invention are selected from the group consisting of l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-l,4- dihydro-pyrrolo[3 ,2-b]pyrrol-2-ylamino)-ethanol, 2-[(5-Amino- 1 ,4-dihydro-pyrrolo[3 ,2- b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin- 1 -yl- 1 ,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ylamine, l-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-4-methyl- 1 ,4-dihydro-pyrrolo[3,2-b]pynOl-2-ylamino)-ethanol,
  • Preferred couplers are selected from the group consisting of 1,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ol, l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-ylamine, 3-chloro-l,4- dihydro-pyrrolo[3,2-b]pyrrol-2-ol, 3-methoxy-l,4-dihydro-pyrrolo[3,2-b]pyrrol-2- ylamine, 1 ,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diol, 1 ,4-dimethyl- 1 ,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ol, 5-amino-l,4-dimethyl-l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-ol, 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3,2-b]pyrrol-2
  • Especially preferred couplers of the present invention are selected from the group consisting of l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-ol, l,4-dihydro-pyrrolo[3,2-b]pyrrol-2- ylamine, l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diol, l,4-dihydro-pyrrolo[3,2-b]pyrrole, 2,5-dimethyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole, l,4-dihydro-pyrrolo[3,2-b]pyrrole-3,6- diol, 2-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole, and (l,4-dihydropyrrolo[3,2-b]pyrrol- 5-yl)methanol.
  • Preferred developers are selected from the group consisting of 4H-furo[3,2- b]pyiTole-2,5-diamine, N , 2'-methyl-4H-furo[3,2-b]pyrrole-2,5-diamine, N'2'-ethyl-4H- furo[3 ,2-b]pyrrole-2,5-diamine, 2-(5-amino-4H-furo[3 ,2-b]pyrrol-2-ylamino)-ethanol, 2- [(5-amino-4H-furo[3,2-b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin-l- yl-4H-furo[3,2-b]pyrrol-5-ylamine, 4-methyl-4H-furo[3,2-b]pyrrole-2,5-diamine, 4-ethyl- N'2'-methyl-4H-furo[3,2-
  • Preferred couplers are selected from the group consisting of 4H-furo[3,2-b]pyrrol- 2-61, 4H-furo[3,2-b]pyrrol-5-ol, 4H-furo[3,2-b]pyrrol-5-ylamine, 4H-furo[3,2-b]pyrrol-2- ylamine, 4-methyl-4H-furo[3,2-b]pyrrol-2-ol, 4-methyl-4H-furo[3,2-b]pyrrol-5-ol, 4- methyl-4H-furo[3,2-b]pyrrol-2-ylamine, 4-methyl-4H-furo[3,2-b>]pyrrol-5-ylamine, 3- chloro-4H-furo[3,2-b]pyrrol-2-ol, 3-chloro-4-methyl-4H-furo[3,2-b]pyrrol-2-ol, 6-chloro- 4H-furo[3,2-b]pyrrol-5-ol, 6-chloro-4-methyl-4H-furo[3,2-b]pyrrol-5-ol, 6-
  • Especially preferred couplers are selected from the group consisting of 4H- furo[3,2-b] ⁇ yrrol-2-ol, 4H-furo[3,2-b]pyrrol-5-ol, 4H-furo[3,2-b]pyrrol-5-ylamine, 4H- furo[3,2-b]pyrrole-2,5-diol, 4H-furo[3,2-b]pyrrole, 2,5-dimethyl-4H-furo[3,2-b]pyrrole, 3,6-dimethyl-4H-furo[3,2-b]pyrrole, 4H-furo[3,2-b]pyrrole-3,6-diol, 2-methyl-4H- furo[3,2-b]pyrrole, 5-methyl-4H-furo[3,2-b]pyrrole, (4H-furo[3,2-b]pyrrol-2-yl)methanol, and (4H-furo[3,2-b]pyrrol-5-yl)methanol.
  • Preferred developers are selected from the group consisting of 4H-thieno[3,2- b]pyrrole-2,5-diamine, N'2'-methyl-4H-thieno[3,2-b]pyrrole-2,5-diamine, N'2'-ethyl-4H- thieno[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-4H-thieno[3,2-b]pyrrol-2-ylamino)- ethanol, 2-[(5-amino-4H-thieno[3,2-b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2- pyrrolidin-l-yl-4H-thieno[3,2-b]py ⁇ iOl-5-ylamine, 4-methyl-4H-thieno[3,2-b]pyrrole-2,5- diamine, 4-ethyl-N'2'-methyl-4H
  • Especially preferred developers of the present invention are selected from the group consisting of 4H-thieno[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-4H-thieno[3,2- b]pyrrol-2-ylamino)-ethanol, 2-[(5-amino-4H-thieno[3,2-b]pyrrol-2-yl)-(2-hydroxy- ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl-4H-thieno[3,2-b]pyrrol-5-ylamine, 4-methyl-4H- thieno[3,2-b]pyrrole-2,5-diamine, 2-[(5-amino-4-methyl-4H-thieno[3,2-b]pynOl-2-yl)-(2- hydroxy-ethyl)-amino]-ethanol, and 4-methyl-2-pyrrolidin-l-yl-4H-thieno[3,2-b]pyrrol-5- ylamine.
  • Preferred couplers are selected from the group consisting of 4H-thieno[3,2- b]pyrrol-2-ol, 4H-thieno[3,2-b]pyrrol-5-ol, 4H-thieno[3,2-b]pyrrol-5-ylamine, 4H- thieno[3,2-b]pyrrol-2-ylamine, 4-methyl-4H-thieno[3,2-b]pyrrol-2-ol, 4-methyl-4H- thieno[3,2-b]pyrrol-5-ol, 4-methyl-4H-thieno[3,2-b]pyrrol-2-ylamine, 4-methyl-4H- thieno[3,2-b]pyrrol-5-ylamine, 3-chloro-4H-thieno[3,2-b]pyrrol-2-ol, 3-chloro-4-methyl- 4H-thieno[3,2-b]pyrrol-2-ol, 6-chloro-4H-thieno[3,2-b]pyrrol-5-ol, 6-chloro-4H-thieno[
  • Especially preferred couplers of the present invention are selected from the group consisting of 4H-thieno[3,2-b]pyrrol-2-ol, 4H-thieno[3,2-b]pyrrol-5-ol, 4H-thieno[3,2- b]pyrrol-5-ylamine, 4H-thieno[3,2-b]pyrrole-2,5-diol, 4H-thieno[3,2-b]pyrrole, 2,5- dimethyl-4H-thieno[3,2-b]pyrrole, 3,6-dimethyl-4H-thieno[3,2-b]pyrrole, 4H-thieno[3,2- b]pyrrole-3,6-diol, 2-methyl-4H-thieno[3,2-b]pyrrole, 5-methyl-4H-thieno[3,2-b]pyrrole, (4H-thieno[3 ,2-b]pyrrol-2-yl)methanol, and (4H-thieno[3 ,2-b]pyrrol-5-yl
  • Furofurans a. Preferred Developers Preferred developers are selected from the group consisting of furo[3,2-b]furan- 2,5-diamine, N , 2'-methyl-furo[3,2-b]furan-2,5-diamine, N , 2'-ethyl-furo[3,2-b]furan-2,5- diamine, 2-(5-amino-furo[3,2-b]furan-2-ylamino)-ethanol, 2-[(5-amino-furo[3,2-b]furan- 2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin- 1 -yl-furo[3 ,2-b]furan-2-ylamine, and 5-amino-furo[3,2-b]furan-2-ol.
  • Especially preferred developers of the present invention are selected from the group consisting of furo[3,2-b]furan-2,5-diamine, N'2'-ethyl-furo[3,2-b]furan-2,5- diamine, 2-(5-amino-furo[3,2-b]furan-2-ylamino)-ethanol, 2-[(5-amino-furo[3,2-b]furan- 2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, and 5-pyrrolidin- 1 -yl-furo[3 ,2-b]furan-2- ylamine.
  • Preferred couplers are selected from the group consisting of furo[3,2-b]furan-2-ol, furo[3,2-b]furan-2-ylamine, 3-chloro-furo[3,2-b]furan-2-ol, 3-methoxy-furo[3,2-b]furan- 2-ylamine, furo[3,2-b]furan-2,5-diol, furo[3,2-b]furan, 2,5-dimethyl-furo[3,2-b]furan, 3,6-dimethyl-mro[3,2-b]furan, furo[3,2-b]furan-3,6-diol, 3-methyl-furo[3,2-b]furan, 2- methyl-furo[3,2-b]furan, 2-methoxyfuro[3,2-b]furan, 2-ethoxyfuro[3,2-b]furan, (furo[3,2- b]furan-5-yl)methanol, and 2-(furo[3,2-b]furan-5-
  • Especially preferred couplers of the present invention are selected from the group consisting of furo[3,2-b]furan-2-ol, furo[3,2-b]furan-2-ylamine, furo[3,2-b]furan-2,5-diol, furo[3,2-b]furan, 2,5-dimethyl-furo[3,2-b]furan, furo[3,2-b]furan-3,6-diol, 2-methyl- furo[3,2-b]furan, and (furo[3,2-b]furan-5-yl)methanol.
  • Thienofurans a.
  • Preferred Developers are selected from the group consisting of thieno[3,2-b]furan- 2,5-diamine, N'5'-methyl-thieno[3,2-b]furan-2,5-diamine, N'5'-ethyl-thieno[3,2-b]furan- 2,5-diamine, 2-(2-amino-thieno[3,2-b]furan-5-ylamino)-ethanol, 2-[(2-amino-thieno[3,2- b]furan-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-thieno[3,2-b]furan-2- ylamine, N'2'-Methyl-thieno[3,2-b]furan-2,5-diamine, N'2'-ethyl-thieno[3,2-b]furan-2,5- diamine, 2-(5-amino-thieno[3,2-b]
  • Especially preferred developers of the present invention are selected from the group consisting of thieno[3,2-b]furan-2,5-diamine, 2-(2-amino-thieno[3,2-b]furan-5 ⁇ ylamino)-ethanol, 2-[(2-amino-thieno[3,2-b]furan-5-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 5-pyrrolidin- l-yl-thieno[3,2-b]furan-2-ylamine, 2-(5-amino-thieno[3,2-b]furan- 2-ylamino)-ethanol, 2-[(5-amino-thieno[3,2-b]furan-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin-l-yl-thieno[3,2-b]furan-5-ylamine, and 5-amino-thieno[3,2-b]furan- 2-ol.
  • Preferred couplers are selected from the group consisting of thieno[3,2-b]furan-2- ol, thieno[3,2-b]furan-5-ol, thieno[3,2-b]furan-5-ylamine, thieno[3,2-b]furan-2-ylamine, 3-chloro-thieno[3,2-b]furan-2-ol, 6-chloro-thieno[3,2-b]furan-5-ol, 3-amino-thieno[3,2- b]fixran-5-ol, 3-methoxy-thieno[3,2-b]furan-2-yIamine, 6-methoxy-thieno[3,2-b]furan-5- ylamine, thieno[3,2-b]furan-2,5-diol, 5-amino-thieno[3,2-b]furan-2-ol, 2-amino- thieno[3,2-b]furan-5-ol, thieno[3,2-b]
  • Especially preferred couplers of the present invention are selected from the group consisting of thieno[3,2-b]furan-2-ol, thieno[3,2-b]furan-5-ol, thieno[3,2-b]furan-5- ylamine, thieno[3,2-b]furan-2,5-diol, thieno[3,2-b]furan, 2,5-dimethyl-thieno[3,2-b]furan, 3,6-dimethyl-thieno[3,2-b]furan, thieno[3,2-b]furan-3,6-diol, 2-methyl-thieno[3,2- b]furan, 5-methyl-thieno[3,2-b]furan, (thieno[3,2-b]furan-2-yl)methanol, and (thieno[3,2- b]furan-5 -yl)methanol .
  • Thienothiophenes are selected from the group consisting of thieno[3,2- b]thiophene-2,5-diamine, N'2'-methyl-thieno[3 ,2-b]thiophene-2,5-diamine, N'2'-ethyl- thieno[3 ,2-b]thiophene-2,5-diamine, 2-(5-amino-thieno[3 ,2-b]thiophen-2-ylamino)- ethanol, 2-[(5-amino-thieno[3,2-b]thiophen-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5- pyrrolidin-l-yl-thieno[3,2-b]thiophen-2-ylamine, 3-methoxy-thieno[3,2-b]thiophene-2,5- diamine, 3-thiophen-2-yl-thieno[3,2-
  • Especially preferred developers of the present invention are selected from the group consisting of thieno[3,2-b]thiophene-2,5-diamine, 2-(5-amino-thieno[3,2- b]thiophen-2-ylamino)-ethanol, 2-[(5-amino-thieno[3,2-b]thiophen-2-yl)-(2-hydroxy- ethyl)-amino]-ethanol, 5-pyrrolidin- l-yl-thieno[3,2-b]thiophen-2-ylamine, and 5-amino- thieno[3,2-b]thiophen-2-ol. a.
  • Preferred Couplers are selected from the group consisting of thieno[3,2- b]thiophen-2-ol, thieno[3,2-b]thiophen-2-ylamine, 3-chloro-thieno[3,2-b]thiophen-2-ol, 3-methoxy-thieno[3,2-b]thiophen-2-ylamine, thieno[3,2-b]thiophen-2,5-diol, thieno[3,2- b]thiophene, 2,5-dimethyl-thieno[3,2-b]thiophene, 3,6-dimethyl-thieno[3,2-b]thiophene, thieno[3,2-b]thiophen-3,6-diol, 3-methyl-thieno[3,2-b]thiophene, 2-methyl-thieno[3,2- bjthiophene, 2-methoxythieno[3,2-b]thiophene, 2-ethoxythieno[3,2-b]thiophen
  • Especially preferred couplers of the present invention are selected from the group consisting of thieno[3,2-b]thiophen-2-ol, thieno[3,2-b]thiophen-2-ylamine, thieno[3,2- b]thiophen-2,5-diol, thieno[3,2-b]thiophene, 2,5-dimethyl-thieno[3,2-b]thiophene, thieno[3,2-b]thiophen-3,6-diol, 2-methyl-thieno[3,2-b]thiophene, (thieno[3,2-b]thiophen- 5-yl)methanol, thieno[3,2-b]thiophene-2-carboxylic acid, thieno[3,2-b]thiophene-2- carboxamide, 5-methyl-thieno[3,2-b]thiophene-2-carboxylic acid, 3,5-diamino- thieno[3,2-b]thiophene-2,6-
  • Bicyclic Bused 5-5 Heteroaromatic Compounds With Three Heteroatoms Bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with three heteroatoms are selected from the group consisting of furooxazoles, pyrrolooxazoles, thienooxazoles, fliroimidazoles, pyrroloimidazoles, thienoimidazoles, furothiazoles, pyrrolothiazoles, thienothiazoles, furooxazoles, and substitutions thereof.
  • Furooxazoles a.
  • Preferred Developers are selected from the group consisting of furo[2,3-d]oxazole- 2,5-diamine, N2-methyl-furo[2,3-d]oxazole-2,5-diamine, N2-ethyl-furo[2,3-d]oxazole- 2,5-diamine, 2-(5-amino-furo[2,3-d]oxazol-2-ylamino)-ethanol, 2-[(5-amino-furo[2,3- d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, N5-methyl-furo[2,3-d]oxazole-2,5- diamine, N5-ethyl-fi ⁇ ro[2,3-d]oxazole-2,5-diamine, 2-(2-amino-furo[2,3-d]oxazol-5- ylamino)-ethanol, 2-[(2-amino-furo[
  • Especially preferred developers of the present invention are selected from the group consisting of furo[2,3-d]oxazole-2,5-diamine, 2-(5-amino-furo[2,3-d]oxazol-2- ylamino)-ethanol, 2-[(5-amino-furo[2,3-d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-(2-amino-furo[2,3-d]oxazol-5-ylamino)-ethanol, 2-[(2-amino-furo[2,3-d]oxazol-5-yl)- (2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-furo[2,3-d]oxazol-2-ylamine, 5- amino-furo[2,3-d]oxazol-2-ol, and 2-amino-furo[2,3-d]oxazol-5-ol
  • Preferred couplers are selected from the group consisting of furo[2,3-d]oxazol-2- ol, furo[2,3-d]oxazol-5-ol, furo[2,3-d]oxazol-5-ylamine, furo[2,3-d]oxazol-2-ylamine, 6- chloro-furo[2,3-d]oxazol-5-ol, 6-amino-furo[2,3-d]oxazol-5-ol, 6-amino-furo[2,3- d]oxazol-2-ol, 3-methoxy-furo[2,3-d]oxazol-2-ylamine, 6-methoxy-furo[2,3-d]oxazol-5- ylamine, furo[2,3-d]oxazol-2,5-diol, 5-amino-furo[2,3-d]oxazol-2-ol, 2-amino-furo
  • Especially preferred couplers of the present invention are selected from the group consisting of furo[2,3-d]oxazol-2-ol, furo[2,3-d]oxazol-5-ol, furo[2,3-d]oxazol-5- ylamine, furo[2,3-d]oxazol-2,5-diol, furo[2,3-d]oxazole, 2,5-dimethyl-furo[2,3-d]oxazole, 2-methyl-furo[2,3-d]oxazole, 5-methyl-furo[2,3-d]oxazole, (furo[2,3-d]oxazol-2- yl)methanol, and (furo[2,3-d]oxazol-5-yl)methanol.
  • Preferred developers are selected from the group consisting of 4H-l-oxa-3,4- diaza-pentalene-2,5-diamine, N2-methyl-4H-l-oxa-3,4-diaza-pentalene-2,5-diamine, N2- ethyl-4H- 1 -oxa-3 ,4-diaza-pentalene-2,5-diamine, 2-(5-amino-4H- 1 -oxa-3 ,4-diaza- pentalen-2-ylamino)-ethanol, 2-[(5-amino-4H-l-oxa-3,4-diaza-pentalen-2-yl)-(2- hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl-4H- 1 -oxa-3 ,4-diaza-pentalen-5 - ylamine, N5-methyl
  • Especially preferred developers are selected from the group consisting of 4H-1- oxa-3,4-diaza-pentalene-2,5-diamine, 2-(5-amino-4H-l -oxa-3, 4-diaza-pentalen-2- ylamino)-ethanol, 2-[(5-amino-4H-l-oxa-3,4-diaza-pentalen-2-yl)-(2-hydroxy-ethyl)- amino]-ethanol, 2-pyrrolidin- 1 -yl-4H- 1 -oxa-3 ,4-diaza-pentalen-5 -ylamine, 5 -amino-4H- 1 -oxa-3, 4-diaza-pentalen-2-ol, and 2-amino-4H-l-oxa-3,4-diaza-pentalen-5-ol.
  • Preferred couplers are selected from the group consisting of 4H-pyrrolo[2,3- d]oxazol-2-ol, 4H-pyrrolo[2,3-d]oxazol-5-ol, 4H-pyrrolo[2,3-d]oxazol-5-ylamine, 4H- pyrrolo[2,3-d]oxazol-2 -ylamine, 4-methyl-4H-pyrrolo[2,3-d]oxazol-2-ol, 4-methyl-4H- pyrrolo[2,3-d]oxazol-5-ol, 4-methyl-4H-pyrrolo[2,3-d]oxazol-2 -ylamine, 4-methyl-4H- pyrrolo[2,3-d]oxazol-5-ylamine, 6-chloro-4H-pyrrolo[2,3-d]oxazol-5-ol, 6-chloro-4-methyl-4H-pyrrolo[2,3-d]oxazol-5-ol, 6-ch
  • Especially preferred couplers are selected from the group consisting of 4H- pyrrolo[2,3-d]oxazol-2-ol, 4H-pyrrolo[2,3-d]oxazol-5-ol, 4H-pyrrolo[2,3-d]oxazol-5- ylamine, 4H-pyrrolo[2,3-d]oxazole-2,5-diol, 4H-pyrrolo[2,3-d]oxazole, 2,5-dimethyl-4H- pyrrolo[2,3-d]oxazole, 4H-pyrrolo[2,3-d]oxazole-3,6-diol, 2-methyl-4H-pyrrolo[2,3- d]oxazole, 5-methyl-4H-pyrrolo[2,3-d]oxazole, (4H-pyrrolo[2,3-d]oxazol-2-yl)methanol, and (4H-pyrrolo[2,3-d]oxazol-5-y
  • Preferred developers are selected from the group consisting of thieno[2,3- d]oxazole-2,5-diamine, N2-methyl-thieno[2,3-d]oxazole-2,5-diamine, N2-ethyl- thieno[2,3-d]oxazole-2,5-diamine, 2-(5-amino-thieno[2,3-d]oxazol-2-ylamino)-ethanol, 2-[(5-amino-thieno[2,3-d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1- yl-thieno[2,3-d]oxazol-5-ylamine, N5-methyl-thieno[2,3-d]oxazole-2,5-diamine, N5- ethyl-thieno[2,3-d]ox
  • Especially preferred developers of the present invention are selected from the group consisting of thieno[2,3-d]oxazole-2,5-diamine, 2-(5-amino-thieno[2,3-d]oxazol-2- ylamino)-ethanol, 2-[(5-amino-thieno[2,3-d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin-l-yl-thieno[2,3-d]oxazol-5-ylamine, 5-amino-thieno[2,3-d]oxazol-2- ol, and 2-Amino-thieno[2,3-d]oxazol-5-ol.
  • Preferred couplers are selected from the group consisting of thieno[2,3-d]oxazol- 2-ol, thieno[2,3-d]oxazol-5-ol, thieno[2,3-d]oxazol-5-ylamine, thieno[2,3-d]oxazol-2- ylamine, 6-chloro-thieno[2,3-d]oxazol-5-ol, 6-amino-thieno[2,3-d]oxazol-5-ol, 6-amino- thieno[2,3-d]oxazol-2-ol, 3-methoxy-thieno[2,3-d]oxazol-2-ylamine, 6-methoxy- thieno[2,3-d]oxazol-5-ylamine, thieno[2,3-d]oxazol-2,5-diol, 5-amino-thieno[2,3--
  • Especially preferred couplers of the present invention are selected from the group consisting of thieno[2,3-d]oxazol-2-ol, thieno[2,3-d]oxazol-5-ol, thieno[2,3-d]oxazol-5- ylamine, thieno[2,3-d]oxazol-2,5-diol, thieno[2,3-d]oxazole, 2,5-dimethyl-thieno[2,3- d]oxazole, 2-methyl-thieno[2,3-d]oxazole, 5-methyl-thieno[2,3-d]oxazole, (thieno[2,3- d]oxazol-2-yl)methanol, and (thieno[2,3-d]oxazol-5-yl)methanol.
  • Furoimidazoles a. Preferred Developers are selected from the group consisting of lH-furo[2,3- d]imidazole-2,5-diamine, N2-methyl-lH-furo[2,3-d]imidazole-2,5-diamine, N2-ethyl-lH- fi ⁇ ro[2,3-d]imidazole-2,5-diamine, 2-(5-amino-lH-furo[2,3-d]imidazol-2-ylamino)- ethanol, 2-[(5-amino-lH-furo[2,3-d]imidazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2- pyrrolidin-l-yl-lH-furo[2,3-d]imidazol-5-ylamine, N5-methyl-lH-fuiO[2,3-d]imidazole- 2,5-di
  • Especially preferred developers of the present invention are selected from the group consisting of lH-furo[2,3-d]imidazole-2,5-diamine, 2-(5-amino-lH-furo[2,3- d]imidazol-2-ylamino)-ethanol, 2-[(5-amino-lH-furo[2,3-d]imidazol-2-yl)-(2-hydroxy- ethyl)-amino] -ethanol, 2-pyrrolidin-l-yl-lH-furo[2,3-d]imidazol-5-ylamine, 5-amino-lH- furo[2,3-d]imidazol-2-ol, and 2-amino-lH-furo[2,3-d]imidazol-5-ol.
  • Preferred couplers are selected from the group consisting of lH-furo[3,2- d]imidazol-2-ol, lH-furo[3,2-d]imidazol-5-ol, lH-furo[3,2-d]imidazol-5-ylamine, 1H- furo[3,2-d]imidazol-2-ylamine, l-methyl-lH-furo[3,2-d]imidazol-2-ol, 1-methyl-lH- furo[3,2-d]imidazol-5-ol, 1 -methyl- lH-furo[3,2-d]imidazol-2-ylamine, 1-methyl-lH- furo[3,2-d]imidazol-5-ylamine, 6-chloro-lH-furo[3,2-d]imidazol-5-ol, 6-chloro-l-methyl- lH-furo[3,2-d]imidazol-5-ol, 6-methoxy
  • Especially preferred couplers are selected from the group consisting of 1H- ftxro[3,2-d]imidazol-2-ol, lH-furo[3,2-d]imidazol-5-ol, lH-furo[3,2-d]imidazol-5- ylamine, lH-fi ⁇ ro[3,2-d]imidazole-2,5-diol, lH-furo[3,2-d]imidazole, 2,5-dimethyl-lH- furo[3,2-d]imidazole, lH-furo[3,2-d]imidazole-3,6-diol, 2-methyl-lH-furo[3,2- d]imidazole, 5-methyl-lH-furo[3,2-d]imidazole, (lH-furo[3,2-d]imidazol-2-yl)methanol, and ( 1 H-furo [3 ,2-d] imidazol-5 -yl)methanol
  • Preferred developers are selected from the group consisting of 1,4-dihydro- pyrrolo[2,3-d]imidazole-2,5-diamine, N2-methyl-l,4-dihydro-pyrrolo[2,3-d]imidazole- 2,5-diamine, N2-ethyl-l,4-dihydro-pyrrolo[2,3-d]imidazole-2,5-diamine, 2-(5-amino-l,4- dihydro-pyrrolo[2,3-d]imidazol-2-ylamino)-ethanol, 2-[(5-amino- 1 ,4-dihydro- pyrrolo[2,3 -d]imidazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl- 1 ,4- dihydro-pyrrolo[2,3-d]imidazole-2,5-diamine, N2-methyl-
  • Especially preferred developers of the present invention are selected from the group consisting of l,4-dihydro-pyrrolo[2,3-d]imidazole-2,5-diamine, 2-(5 -amino- 1,4- dihydro-pyrrolo[2,3-d]imidazol-2-ylamino)-ethanol, 2-[(5-amino- 1 ,4-dihydro- pyrrolo[2,3 -d]imidazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl- 1 ,4- dihydro-pyrrolo[2,3-d]imidazol-5-ylamine, 5-amino-l,4-dihydro-pyrrolo[2,3-d]imidazol- 2-ol, and 2-amino-l,4-dihydro-pyrrolo[2,3-d]imidazol-5-ol.
  • Couplers are selected from the group consisting of 1,4-dihydro- pyrrolo[3,2-d]imidazol-2-ol, l,4-dihydro-pyrrolo[3,2-d]imidazol-2-ylamine, 1,4-dihydro- pyrrolo[3,2-d]imidazole-2,5-diol, 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3,2-d]imidazol-2-ol, 5-amino- 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3,2-d]imidazol-2-ol, 1 ,4-dimethyl- 1 ,4- dihydro-py ⁇ rolo[3 ,2-d]imidazol-2-ylamine, 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3 ,2- d]imidazol-2-ylamine, 1
  • Especially preferred couplers of the present invention are selected from the group consisting of l,4-dihydro-pyrrolo[3,2-d]imidazol-2-ol, l,4-dihydro-pyrrolo[3,2- d]imidazol-2 -ylamine, 1 ,4-dihydro-pyrrolo[3,2-d]imidazole-2,5-diol, 1 ,4-dihydro- pyrrolo[3,2-d]imidazole, 2,5-dimethyl-l,4-dihydro-pyrrolo[3,2-d]imidazole, 2-methyl- 1 ,4-dihydro-pyrrolo[3,2-d]imidazole, and (1 ,4-dihydropyrrolo[3,2-d]imidazol-5- yl)methanol.
  • Preferred developers are selected from the group consisting of lH-thieno[2,3- d]imidazole-2,5-diamine, N2-methyl-lH-thieno[2,3-d]imidazole-2,5-diamine, N2-ethyl- lH-thieno[2,3-d]imidazole-2,5-diamine, 2-(5-amino-lH-thieno[2,3-d]imidazol-2- ylamino)-ethanol, 2 ⁇ [(5-amino-lH-thieno[2,3-d]imidazol-2-yl)-(2-hydroxy-ethyl)- amino] -ethanol, 2-pyrrolidin-l-yl-lH-thieno[2,3-d]imidazol-5-ylamine, N5-methyl-lH- thieno[2,3-d]imidazole-2,5-di
  • Especially preferred developers of the present invention are selected from the group consisting of lH-thieno[2,3-d]imidazole-2,5-diamine, 2-(5-amino-lH-thieno[2,3- d]imidazol-2-ylamino)-ethanol, 2-[(5-amino-lH-thieno[2,3-d]imidazol-2-yl)-(2 -hydroxy- ethyl)-amino]-ethanol, 2-pyrrolidin-l-yl-lH-thieno[2,3-d]imidazol-5-ylamine, 5-amino- lH-thieno[2,3-d]imidazol-2-ol, and 2-amino-lH-thieno[2,3-d]imidazol-5-ol.
  • Preferred couplers are selected from the group consisting of 1 H-thieno [3 ,2- d]imidazol-2-ol, lH-thieno[3,2-d]imidazol-5-ol, lH-thieno[3,2-d]imidazol-5-ylamine, lH-thieno[3,2-d]imidazol-2 -ylamine, 1 -methyl- lH-thieno[3,2-d]imidazol-2-ol, 1 -methyl- lH-thieno[3,2-d]imidazol-5-ol, 1 -methyl- lH-thieno [3, 2-d]imidazol-2-ylamine, 1-methyl- lH-thieno[3,2-d]imidazol-5-ylamine, 6-chloro-lH-thieno[3,2-d]imidazol-5-ol, 6-chloro- 1 -methyl- 1 H-thieno
  • Especially preferred couplers are selected from the group consisting of 1H- thieno[3,2-d]imidazol-2-ol, lH-thieno[3,2-d]imidazol-5-ol, lH-thieno[3,2-d]imidazol-5- ylamine, lH-thieno[3,2-d]imidazole-2,5-diol, lH-thieno[3,2-d]imidazole, 2,5-dimethyl- lH-thieno[3,2-d]imidazole, lH-thieno[3,2-d]imidazole-3,6-diol, 2-methyl- lH-thieno[3,2- d]imidazole, 5-methyl-lH-thieno[3,2-d]imidazole, (lH-thieno[3,2-d]imidazol-2- yl)methanol, and (lH-thieno[3,2-d]imidazol-5-
  • Preferred developers are selected from the group consisting of furo[2,3-d]thiazole- 2,5-diamine, N2-methyl-furo[2,3-d]thiazole-2 5 5-diamine, N2-ethyl-furo[2,3-d]thiazole- 2,5-diamine, 2-(5-amino-furo[2,3-d]thiazol-2-ylamino)-ethanol, 2-[(5-amino-furo[2,3- d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin-l-yl-furo[2,3-d]thiazol-5- ylamine, N5-methyl-furo[2,3-d]thiazole-2,5-diamine, N5-ethyl-furo[2,3-d]thiazole-2,5- diamine, 2-(2-amino-furo[2,3-d]thiazole-2,5- diamine
  • Especially preferred developers of the present invention are selected from the group consisting of furo[2,3-d]thiazole-2,5-diamine, 2-(5-amino-furo[2,3-d]thiazol-2- ylamino)-ethanoI, 2-[(5-amino-furo[2,3-d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin- 1 -yl-furo[2,3-d]thiazol-5-ylamine, 5-amino-furo[2,3-d]thiazol-2-ol, and 2-amino-furo[2,3-d]thiazol-5-ol.
  • furo[2,3-d]thiazole-2,5-diamine 2-(5-amino-furo[2,3-d]thiazol-2- ylamino)-ethanoI
  • Preferred couplers are selected from the group consisting of furo[2,3-d]thiazol-2- ol, furo[2,3-d]thiazol-5-ol, furo[2,3-d]thiazol-5-ylamine, furo[2,3-d]thiazol-2-ylamine, 6- chloro-furo[2,3-d]thiazol-5-ol, 6-amino-furo[2,3-d]thiazol-5-ol, 6-amino-furo[2,3- d]thiazol-2-ol, 3-methoxy-furo[2,3-d]thiazol-2 -ylamine, 6-methoxy-furo[2,3-d]thiazol-5- ylamine, furo[2,3-d]thiazol-2,5-diol, 5-amino-furo[2,3-d]thiazol-2-ol, 2-amino-furo[2,3- d]thiazol-5-o
  • Especially preferred couplers of the present invention are selected from the group consisting of furo[2,3-d]thiazol-2-ol, furo[2,3-d]thiazol-5-ol, fi ⁇ ro[2,3-d]thiazol-5- ylamine, furo[2,3-d]thiazol-2,5-diol, furo[2,3-d]thiazole, 2,5-dimethyl-furo[2,3- d]thiazole, 2-methyl-furo[2,3-d]thiazole, 5-methyl-furo[2,3-d]thiazole, (furo[2,3- d]thiazol-2-yl)methanol, and (furo[2,3-d]thiazol-5-yl)methanol.
  • Preferred developers are selected from the group consisting of 4H-Pyrrolo[2,3- d]thiazole-2,5-diamine, N2-methyl-4H-pyrrolo[2,3-d]thiazole-2,5-diamine, N2-ethyl-4H- pynOlo[2,3-d]thiazole-2,5-diamine, 2-(5-amino-4H-pyrrolo[2,3-d]thiazol-2-ylamino)- ethanol, 2-[(5-amino-4H-pyrrolo[2,3-d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin-l-yl-4H-pyrrolo[2,3-d]thiazol-5-ylamine, N5-ethyl-4H-pyrrolo[2,3- d]thiazole-2,5-diamine, N5-
  • Especially preferred developers of the present invention are selected from the group consisting of 4H-Pyrrolo[2,3-d]thiazole-2,5-diamine, N2-methyl-4H-pyrrolo[2,3- d]thiazole-2,5-diamine, N2-ethyl-4H-pyrrolo[2,3-d]thiazole-2,5-diamine, 2-(5-amino-4H- pyrrolo[2,3-d]thiazol-2-ylamino)-ethanol, 2-[(5-amino-4H-pyrrolo[2,3-d]thiazol-2-yl)-(2- hydroxy-ethyl)-amino]-ethanol, 2-py ⁇ Olidin-l-yl-4H-pyrrolo[2,3-d]thiazol-5-ylamine, 5- amino-4H-pyrrolo[2,3-d]thiazol-2-ol, and 2-amino-4H-pyrrolo[2,3-d]thiazol-5-
  • Preferred couplers are selected from the group consisting of 4H-pyrrolo[2,3- d]thiazol-2-ol, 4H-pyrrolo[2,3-d]thiazol-5-ol, 4H-pyrrolo[2,3-d]thiazol-5-ylamine, 4H- pyrrolo[2,3-d]thiazol-2-ylamine, 4-methyl-4H-pyrrolo[2,3-d]thiazol-2-ol, 4-methyl-4H- pyrrolo[2,3-d]thiazol-5-ol, 4-methyl-4H-pyrrolo[2,3-d]thiazol-2-ylamine, 4-methyl-4H- pyrrolo[2,3-d]thiazol-5-ylamine, 6-chloro-4H-pyrrolo[2,3-d]thiazol-5-ol, 6-chloro-4-methyl-4H-pyrrolo[2,3-d]thiazol-5-ol, 6-chloro-4- methyl-4H-pyrrolo
  • Especially preferred couplers are selected from the group consisting of 4H- pyr ⁇ olo[2,3-djthiazol-2-ol, 4H-pyrrolo[2,3-d]thiazol-5-ol, 4H-pyrrolo[2,3-d]thiazol-5- ylamine, 4H-pyrrolo[2,3-d]thiazole-2,5-diol, 4H-pyrrolo[2,3-d]thiazole, 2,5-dimethyl-4H- pyrrolo[2,3-d]thiazole, 4H-pyrrolo [2,3-d]thiazole-3,6-diol, 2-methyl-4H-pyrroIo[2,3- djthiazole, 5-methyl-4H-pynolo[2,3-d]thiazole, (4H-pyrrolo[2,3-d]thiazol-2-yl)methanol, and (4H-pyrrolo[2,3-d]thiazol-5-yl)methanol
  • Preferred developers are selected from the group consisting of thieno[2,3- d]thiazole-2,5-diamine, N2-methyl-thieno[2,3-d]thiazole-2,5-diamine, N2-ethyl- thieno[2,3-d]thiazole-2,5-diamine, 2-(5-amino-thieno[2,3-d]thiazol-2-ylamino)-ethanol, 2-[(5-amino-thieno[2,3-d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 - yl-thieno[2,3-d]thiazol-5-ylamine, KT5-methyl-thieno[2,3-d]thiazole-2,5-diamine, N5- ethyl-thieno[2,3-d]thiazole-2,5-
  • Especially preferred developers of the present invention are selected from the group consisting of thieno[2,3-d]thiazole-2,5-diamine, 2-(5-amino-thieno[2,3-d]thiazol-2- ylamino)-ethanol, 2-[(5-amino-thieno[2,3-d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin-l-yl-thieno[2,3-d]thiazol-5-ylamine, 5-amino-thieno[2,3-d]thiazol- 2-ol, and 2-amino-thieno[2,3-d]thiazol-5-ol.
  • thieno[2,3-d]thiazole-2,5-diamine 2-(5-amino-thieno[2,3-d]thiazol-2- ylamino)-ethanol
  • Preferred couplers are selected from the group consisting of thieno[2,3-d]thiazol- 2-ol, thieno[2,3-d]thiazol-5-ol, thieno[2,3-d]thiazol-5-ylamine, thieno[2,3-d]thiazol-2- ylamine, 6-chloro-thieno[2,3-d]thiazol-5-ol, 6-amino-thieno[2,3-d]thiazol-5-ol, 6-amino- thieno[2,3-d]thiazol-2-ol, 3-methoxy-thieno[2,3-d]thiazol-2-ylamine, 6-methoxy- thieno[2,3-d]thiazol-5-ylamine, thieno[2,3-d]thiazol-2,5-diol, 5-amino-thieno[2,3- d]thiazol-2-ol, 2-amin
  • Especially preferred couplers of the present invention are selected from the group consisting of thieno[2,3-d]thiazol-2-ol, thieno[2,3-d]thiazol-5-ol, thieno[2,3-d]thiazol-5- ylamine, thieno[2,3-d]thiazol-2,5-diol, thieno[2,3-d]thiazole, 2,5-dimethyl-thieno[2,3- d]thiazole, 2-methyl-thieno[2,3-d]thiazole, 5-methyl-thieno[2,3-d]thiazole, (thieno[2,3- d]thiazol-2-yl)methanol, and (thieno[2,3-d]thiazol-5-yl)methanol.
  • Preferred developers are selected from the group consisting of furo[2,3-d]oxazole- 2,5-diamine, N2-methyl-furo[2,3-d]oxazole-2,5-diamine, N2-ethyl-furo[2,3-d]oxazole- 2,5-diamine, 2-(5-amino-furo[2,3-d]oxazol-2-ylamino)-ethanol, 2-[(5-amino-furo[2,3- d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin-l-yl-furo[2,3-d]oxazol-5- ylamine, N5-methyl-furo[2,3-d]oxazole-2,5-diamine, N5-ethyl-furo[2,3-d]oxazole-2,5- diamine, 2-(
  • Especially preferred developers of the present invention are selected from the group consisting of furo[2,3-d]oxazole-2,5-diamine, 2-(5-amino-furo[2,3-d]oxazol-2- ylamino)-ethanol, 2-[(5-amino-furo[2,3-d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- l-yl-furo[2,3-d]oxazol-5-ylamine, 5-amino-furo[2,3-d]oxazol-2-ol, and 2- amino-furo[2,3-d]oxazol-5-ol.
  • furo[2,3-d]oxazole-2,5-diamine 2-(5-amino-furo[2,3-d]oxazol-2- ylamino)-ethanol
  • Preferred couplers are selected from the group consisting of furo[2,3-d]oxazol-2- ol, fi ⁇ ro[2,3-d]oxazol-5-ol, furo[2,3-d]oxazol-5-ylamine, furo[2,3-d]oxazol-2-ylamine, 6- chloro-furo[2,3-d]oxazol-5-ol, 6-amino-furo[2,3-d]oxazol-5-ol, 6-amino-furo[2,3- d]oxazol-2-ol, 3-methoxy-furo[2,3-d]oxazol-2-ylamine, 6-methoxy-furo[2,3-d]oxazol-5- ylamine, furo[2,3-d]oxazol-2,5-diol, 5-amino-furo[2,3-d]oxazol-2-ol, 2-amino-furo[
  • Especially preferred couplers of the present invention are selected from the group consisting of furo[2,3-d]oxazol-2-ol, furo[2,3-d]oxazol-5-ol, furo[2,3-d]oxazol-5- ylamine, furo[2,3-d]oxazol-2,5-diol, fixro[2,3-d]oxazole, 2,5-dimethyl-furo[2,3-d]oxazole, 2-methyl-furo[2,3-d]oxazole, 5-methyl-furo[2,3-d]oxazole, (furo[2,3-d]oxazol-2- yl)methanol, and (furo[2,3-d]oxazol-5-yl)methanol.
  • D Synthesis Examples The following are non-limiting synthesis examples of the present invention.
  • Example C l,4-Dihydropyrrolo[3,2-b]pyrrole, obtainable from the following synthesis strategy: Br -Br ⁇
  • Example E Thieno[3,2-b]thiophene-2-carboxylic acid available from Maybridge pic,
  • Example F Thieno[2,3-d]thiazole-6-carboxylic acid, 2-amino-, methyl ester available from SPECS and BioSPECS B.N., Netherlands.
  • Example K Urea, N-hydroxy-N-(thieno[3,2-b]thien-2-ylmethyl)- available from
  • the inventive compositions for the oxidative dyeing of keratin fibers comprise the hair-dyeing compound described above in the hair-dyeing compounds section and a medium suitable for dyeing.
  • the inventive compositions may further comprise additional components known, conventionally used, or otherwise effective for use in oxidative dye compositions, including but limited to: developer dye compounds; coupler dye compounds; direct dyes; oxidizing agents; thickeners; chelants; pH modifiers and buffering agents; carbonate ion sources and radical scavenger systems; anionic, cationic, nonionic, amphoteric or zwitterionic surfactants, or mixtures thereof; anionic, cationic, nonionic, amphoteric or zwitterionic polymers, or mixtures thereof; fragrances; buffers; dispersing agents; peroxide stabilizing agents; natural ingredients, e.g.
  • the medium suitable for dyeing may be selected from water, or a mixture of water and at least one organic solvent to dissolve the compounds that would not typically be sufficiently soluble in water.
  • Suitable organic solvents for use herein include, but are not limited to: CI to C4 lower alkanols (e.g., ethanol, propanol, isopropanol), aromatic alcohols (e.g.
  • polyols and polyol ethers e.g., carbitols, 2-butoxyethanol, propylene glycol, propylene glycol monomethyl ether, diethylene glycol monoethyl ether, monomethyl ether, hexylene glycol, glycerol, ethoxy glycol), and propylene carbonate.
  • organic solvents are typically present in an amount ranging from 1% to 30%, by weight, of the composition.
  • Preferred solvents are water, ethanol, propanol, isopropanol, glycerol, 1,2-propylene glycol, hexylene glycol, ethoxy diglycol, and mixtures thereof.
  • Suitable developers for use in the compositions described herein include, but are not limited to p-phenylenediamine derivatives, e.g. benzene- 1,4-diamine (commonly known as p-phenylenediamine), 2 -methyl-benzene- 1,4-diamine, 2-chloro-benzene-l ,4- diamine, N-phenyl -benzene- 1,4-diamine, N-(2-ethoxyethyl)benzene- 1,4-diamine, 2- (4- amino-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol, (commonly known as N,N-bis(2- hydroxyethyl)-p-phenylenediamine) (2,5-diamino-phenyl)-methanol, l-(2'-
  • Additional developers are selected from the group consisting of N-(3- furylmethyl)benzene- 1 ,4-diamine; N-Thiophen-3 -ylmethyl-benzene- 1 ,4-diamine; N-(2- furylmethyl)benzene- 1 ,4-diamine; ⁇ -Thiophen-2 -ylmethyl-benzene- 1 ,4-diamine; 4- Hydroxy-benzoic acid (2,5-diamino-benzylidene)-hydrazide; 3-(2,5-Diamino-phenyl)-N- ethyl-acrylamide; 2-[3-(3-Amino-phenylamino)-propenyl]-benzene-l,4-diamine; 2-[3-(4- Amino-phenylamino)-propenyl]-benzene- 1 ,4-diamine; 2-(6-Methyl-pyridin-2-yl)- benz
  • Preferred developers include but are not limited to: p-phenylenediamine derivatives such as: 2-methyl-benzene- 1,4-diamine; benzene- 1,4-diamine; l-(2,5- diamino-phenyl)-ethanol; 2-(2,5-diamino-phenyl)-ethanol; N-(2-methoxyethyl)benzene- 1 ,4-diamine; 2-[(4-amino-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol; 1 -(2,5- diaminophenyl)ethane-l,2-diol; l-(2'-Hydroxyethyl)-2,5-diaminobenzene; l,3-Bis(N(2- Hydroxyethyl)-N-(4-amino-phenyl)amino)-2-propanol; 2,2'-[l,2-Ethane
  • More preferred developers include: 2 -methyl-benzene- 1,4-diamine; benzene- 1,4- diamine; N,N-Bis(2-hydroxyethyl)-p-phenylenediamine; 4-amino-phenol; 4- methylamino-phenol; 4-amino-3-methyl-phenol; l-Hydroxy-2,4-diaminobenzene; 2- amino-phenol; 2-amino-5-methyl-phenol; 2-amino-6-methyl-phenol; 1 -methyl- 1H- pyrazole-4,5-diamine; l-Hydroxyethyl-4,5-diaminopyrazole sulphate; 2-(4,5-diamino- lH-pyrazol-l-yl)ethanol; and mixtures thereof.
  • Suitable couplers for use in the compositions described herein include, but are not limited to: phenols, resorcinol and naphthol derivatives such as: naphthalene- 1,7-diol, benzene- 1,3 -diol, 4-chlorobenzene- 1,3 -diol, naphthalen-1-ol, 2-methyl-naphthalen-l-ol, naphthalene- 1,5-diol, naphthalene-2,7-diol, benzene- 1,4-diol, 2-methyl-benzene-l,3-diol, 7-amino-4-hydroxy-naphthalene-2-sulfonic acid, 2-isopropyl-5-methylphenol, 1,2,3,4- tetrahydro-naphthalene- 1 ,5-diol, 2-chloro-benzene- 1 ,3 -d
  • Additional couplers are selected from the group consisting of N-(3- furylmethyl)benzene- 1 ,4-diamine; ⁇ -Thiophen-3-ylmethyl-benzene- 1 ,4-diamine; N-(2- fu ⁇ ylmethyl)benzene- 1 ,4-diamine; ⁇ -Thiophen-2 -ylmethyl-benzene- 1 ,4-diamine; 4- Hydroxy-benzoic acid (2,5-diamino-benzylidene)-hydrazide; 3-(2,5-Diamino-phenyl)-N- ethyl-acrylamide; 2-[3-(3-Amino-phenylamino)-propenyl]-benzene- 1 ,4-diamine; 2-[3-(4- Amino-phenylamino)-propenyl]-benzene- 1 ,4-diamine; 2-(6-Methyl-pyridin-2-y
  • Phenylaminomethyl-benzene- 1 ,3-diamine hydrochloride 5-(3- Amino- phenyl)aminomethyl-benzene-l,3-diamine hydrochloride; 4-Thiophen-3-yl-benzene-l,3- diamine; hydrochloride; 2',4'-Diamino-biphenyl-4-ol; hydrochloride; 5-Cyclobutylamino- 2-methyl-phenol; 5-Cyclobutylamino-2-methyl-phenol; 4-Amino-2-(pyridin-3- ylaminomethyl)- ⁇ henol; 5-(3-Amino-phenyl)aminomethyl-benzene- 1 ,3-diamine hydrochloride; 5-Allylaminomethyl-benzene-l,3-diamine hydrochloride; N-(4-Amino- benzyl)-benzene- 1 ,3-diamine hydrochloride;
  • Preferred couplers include but are not limited to: phenol, resorcinol, and naphthol derivatives such as: naphthalene- 1,7-diol, benzene- 1,3-diol, 4-chlorobenzene- 1,3-diol, naphthalen-1-ol, 2-methyl-naphthalen-l-ol, naphthalene- 1,5-diol, naphthalene-2,7-diol, benzene- 1,4-diol, 2-methyl-benzene- 1,3-diol, and 2-isopropyl-5-methylphenol; 1,2,4- Trihydroxybenzene; l-Acetoxy-2-methylnaphthalene;and mixtures thereof; m- phenylenediamine derivatives such as: benzene- 1,3 -diamine, 2-(2,4-diamino-phenoxy)- ethanol, 4- ⁇ 3-[(2,4-
  • More preferred couplers include: benzene- 1,3-diol; 4-chlorobenzene- 1,3-diol; 2- methyl-benzene- 1,3-diol; benzene- 1,3-diamine; 3-amino-phenol; 5-amino-2-methyl- phenol; 1 -Methyl-2-hydroxy-4-(2'-hydroxyethyl)aminobenzene; 4-methyl-2-phenyl-2,4- dihydro-3H-pyrazol-3-one; 2-aminopyridin-3-ol; l-phenyl-3-methylpyrazol-5-one; 1- Phenyl-3-methyl-5-pyrazolone-2,4-dihydro-5,2-phenyl-3H-pyrazole-3-one; and mixtures thereof.
  • Additional preferred developers and couplers include 5-methoxymethyl-2- aminophenol, 5-ethyl-2-aminophenol, 5-phenyl-2-aminophenol, and 5-cyanoethyl-2- aminophenol.
  • Further additional preferred developers and couplers include: 5-membered heteroaromatic keratin dyeing compounds with one, two, or three heteroatoms relating to the following compounds: wherein Z is selected from the group consisting of S and O; wherein Y is selected from the group consisting of NA 1 , S and O; Bicyclic 5-5 heteroaromatic compounds having a ring junction nitrogen according to the following formulas:
  • Y is selected from the group consisting of S and O; Tricyclic 5-6-5 heteroaromatic keratin dyeing compounds having two heteroatoms according to the following formulas:
  • Y and Z are selected from the group consisting of NA 1 , S, and O; Bicyclic 5-6 heteroaromatic keratin dyeing compounds with one ring junction nitrogen and one or two extra heteroatoms according to the following formulas:
  • Tricyclic fused 6-5-6 heteroaromatic keratin dyeing compounds having one heteroatom according to the following formula:
  • Y is independently selected from the group consisting of NA 1 , S and O; 5-membered aza heteroaromatic keratin dyeing compounds with an N-hydroxy or N- amino group and derivatives thereof, according to the following formulas:
  • Bi, B 2 , B 3 , and B 4 are selected from the group consisting of CH and N; wherein the corresponding R 1 , R 2 , R 3 ,and R 4 is absent when B is N; Bicyclic 5-6 systems of aza heteroaromatic keratin dyeing compounds wherein the 5- membered rings have one to three nitrogen atoms and an N-hydroxy or N-amino group and derivatives thereof, according to the following formulas: I II wherein Bj and B 2 are independently selected from CH or N; wherein the corresponding R 1 and R 2 is absent when B is N; Bicyclic fused 5-5-membered aza heteroaromatic keratin dyeing compounds with an N- hydroxy or N-amino group and derivatives thereof, according to the following formulas:
  • Bicyclic fused 5-5-membered aza heteroaromatic keratin dyeing compounds having a ring junction nitrogen and an N-hydroxy or N-amino group and derivatives thereof, according to the following formulas:
  • Bicyclic fused 5-5-membered aza heteroaromatic keratin dyeing compounds having a ring junction nitrogen and an N-hydroxy or N-amino group and derivatives thereof, according to the following formulas:
  • Bi, B 2 , B , B 4j and B 5 are selected from the group consisting of CH and N; wherein the corresponding R1,R2, R3, R4 , and R5 is absent when B is N; wherein all of the aforementioned R groups are the same or different and are selected from the group consisting of: (a) C-linked monovalent substituents selected from the group consisting of: (i) substituted or unsubstituted, straight or branched, alkyl, mono- or poly- unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefinic systems, (ii) substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems, and (iii) substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems; wherein said systems of (i), (ii) and (iii) comprise from about 1 to about 10 carbon atoms
  • a 1 , A 2 , and A 3 are monovalent and are independently selected from the group consisting of: H; substituted or unsubstituted, straight or branched, alkyl, mono- or poly-unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefinic systems; substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems; and substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems, or A 1 and A 2 together with nitrogen atoms to
  • inventive compositions may also comprise compatible direct dyes, in an amount sufficient to provide additional coloring, particularly with regard to intensity. Typically, such an amount will range from 0.05% to 4%, by weight, of the composition.
  • Suitable direct dyes include but are not limited to: Acid Yellow 1, Acid Orange 3, Disperse Red 17, Basic Brown 17, Acid Black 52, Acid Black 1, Disperse Violet 4, 4- Nitro-o-Phenylenediamine, 2-Nitro-p-Phenylenediamine, Picramic Acid, HC Red No. 13, l,4-Bis-(2'-Hydroxyethyl)-amino-2-nitrobenzene, HC Yellow No. 5, HC Red No. 7, HC Blue No. 2, HC Yellow No.
  • HC Red No. 8 HC Green No. 1, HC Red No. 9, 2-Hydroxy-l,4-naphthoquinone, Acid Blue 199, Acid Blue 25, Acid Red 4, Henna Red, Indigo, Cochenille, HC Blue 14, Disperse Blue 23, Disperse Blue 3, Violet 2, Disperse Blue 377, Basic Red 51, Basic Orange 31, Basic Yellow 87, and mixtures thereof.
  • Preferred direct dyes include but are not limited to: Disperse Black 9, HC Yellow 2, HC Yellow 4, HC Yellow 15, 4-nitro-o- phenylenediamine, 2-amino-6-chloro-4-nitrophenol, HC Red 3, Disperse Violet 1, HC Blue 2, Disperse Blue 3, Disperse Blue 377, Basic Red 51, Basic Orange 31, Basic Yellow 87, and mixtures thereof.
  • the inventive compositions may comprise an oxidizing agent, present in an amount sufficient to bleach melanin pigment in hair and/or cause formation of dye chromophores from oxidative dye precursors (including developers and/or couplers when present).
  • Inorganic peroxygen materials capable of yielding hydrogen peroxide in an aqueous medium are preferred, and include but are not limited to: hydrogen peroxide; inorganic alkali metal peroxides (e.g. sodium periodate and sodium peroxide); organic peroxides (e.g. urea peroxide, melamine peroxide); inorganic perhydrate salt bleaching compounds (e.g.
  • compositions may comprise a thickener in an amount sufficient to provide the composition with a viscosity so that it can be readily applied to the hair without unduly dripping off the hair and causing mess. Typically, such an amount will be at least 0.1%, preferably at least 0.5%, more preferably, at least 1%, by weight, of the composition.
  • salt tolerant thickeners including but not limited to: xanthan, guar, hydroxypropyl guar, scleroglucan, methyl cellulose, ethyl cellulose (available as AQUACOTE (TM)), hydroxyethyl cellulose (NATROSOL (TM)), carboxymethyl cellulose, hydroxypropylmethyl cellulose, microcrystalline cellulose, hydroxybutylmethyl cellulose, hydroxypropyl cellulose (available as KLUCEL (TM)), hydroxyethyl ethyl cellulose, cetyl hydroxyethyl cellulose (available as NATROSOL (TM) Plus 330), N-vinylpyrollidone (available as POVIDONE (TM)), Acrylates/Ceteth- 20 Itaconate Copolymer (available as STRUCTURE (TM) 3001), hydroxypropyl starch phosphate (available as STRUCTURE (TM) ZEA), polyethoxylated
  • PEG-150/Decyl/SMDI copolymer available as ACULYN(TM) 44
  • PEG-150/Stearyl/SMDI copolymer available as ACULYN(TM) 46
  • trihydroxystearin available as THIXCIN(TM)
  • acrylates copolymer e.g. available as ACULYN(TM) 33
  • hydrophobically modified acrylate copolymers e.g.
  • the inventive compositions may comprise chelants in an amount sufficient to reduce the amount of metals available to interact with formulation components, particularly oxidizing agents, more particularly peroxides. Typically such an amount will range from at least 0.25%, preferably at least 0.5%, by weight, of the composition.
  • Suitable chelants for use herein include but are not limited to: diamine-N,N'-dipolyacid, monoamine monoamide-N,N'-dipolyacid, and N,N'-bis(2- hydroxybenzyl)ethylenediamine-N,N'-diacetic acid chelants (preferably EDDS (ethylenediaminedisuccinic acid)), carboxylic acids (preferably aminocarboxylic acids), phosphonic acids (preferably aminophosphonic acids) and polyphosphoric acids (in particular straight polyphosphoric acids), their salts and derivatives.
  • diamine-N,N'-dipolyacid preferably aminocarboxylic acids
  • phosphonic acids preferably aminophosphonic acids
  • polyphosphoric acids in particular straight polyphosphoric acids
  • the inventive compositions may further comprise a pH modifier and/or buffering agent in an amount that is sufficiently effective to adjust the pH of the composition to fall within a range from 3 to 13, preferably from 8 to 12, more preferably from 9 to 11.
  • Suitable pH modifiers and/or buffering agents for use herein include, but are not limited to: ammonia, alkanolamides such as monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, dipropanolamine, tripropanolamine, tripropanolamine, 2-amino-2- methyl-1 -propanol, and 2-amino-2-hydroxymethyl-l,3,-propandiol and guanidium salts, alkali metal and ammonium hydroxides and carbonates, preferably sodium hydroxide and ammonium carbonate, and acidulents such as inorganic and inorganic acids, e.g., phosphoric acid, acetic acid, ascorbic acid, citric acid or tartaric acid, hydro
  • the inventive compositions may comprise a system comprising a source of carbonate ions, carbamate ions and or hydrocarbonate ions, and a radical scavenger, in a sufficient amount to reduce damage to the hair during the coloring process.
  • a source of carbonate ions, carbamate ions and or hydrocarbonate ions, and a radical scavenger in a sufficient amount to reduce damage to the hair during the coloring process.
  • such an amount will range from 0.1% to 15%, preferably 0.1% to 10%, more preferably 1% to 7%, by weight of the composition, of the carbonate ion, and from 0.1% to 10%, preferably from 1% to 7%, by weight of the composition, of radical scavenger.
  • the radical scavenger is present at an amount such that the ratio of radical scavenger to carbonate ion is from 1:1 to 1:4.
  • the radical scavenger is preferably selected such that it is not an identical species as the alkalizing agent.
  • Suitable sources for the ions include but are not limited to: sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, guanidine carbonate, guanidine hydrogen carbonate, lithium carbonate, calcium carbonate, magnesium carbonate, barium carbonate, ammonium carbonate, ammonium hydrogen carbonate and mixtures thereof.
  • Preferred sources of carbonate ions are sodium hydrogen carbonate and potassium hydrogen carbonate. Also preferred are ammonium carbonate, and ammonium hydrogen carbonate.
  • the radical scavenger is a species that can react with a carbonate radical to convert the carbonate radical by a series of fast reactions to a less reactive species.
  • radical scavengers may be selected from the classes of alkanolamines, amino sugars, amino acids and mixtures thereof, and may include, but are not limited to: monoethanolamine, 3-amino-l -propanol, 4-amino-l- butanol,5-amino-l-pentanol, l-amino-2-propanol, l-amino-2-butanol, l-amino-2- pentanol, l-amino-3-pentanol, l-amino-4-pentanol, 3-amino-2-methylpropan-l-ol, 1- amino-2-methylpropan-2-ol, 3-aminopropane-l,2-diol, glucosamine, N- acetylglucosamine,
  • the compounds of this invention may be obtained using conventional methods. A general description of how to make the compounds is provided above and specific examples are provided below.
  • the compositions of this invention may also be obtained using conventional methods.
  • the keratin dyeing compositions may be formed as solutions, preferably as aqueous or aqueous-alcohol solutions.
  • the hair dye product compositions may preferably be formed as thick liquids, creams, gels, or emulsions whose composition is a mixture of the dye compound and other dye ingredients with conventional cosmetic additive ingredients suitable for the particular preparation.
  • inventive keratin dyeing compositions may be used by admixing them with a suitable oxidant, which reacts with the oxidative dye precursors to develop the hair dye product composition.
  • the oxidant is usually provided in an aqueous composition, which normally is provided as a separate component of the finished keratin dyeing product system and present in a separate container.
  • the adjuvants are provided in the hair dye composition as it is applied to the hair to achieve desired product attributes, e.g., pH, viscosity, rheology, etc.
  • the keratin dyeing composition as it is applied to the hair, can be weakly acidic, neutral or alkaline according to their composition, typically having a pH from 6 to 11, preferably from 7 to 10, more preferably from 8 to 10.
  • the pH of the developer composition is typically acidic, and generally the pH is from 2.5 to 6.5, preferably from 3 to 5.
  • the pH of the hair compositions may be adjusted using a pH modifier as mentioned above.
  • the above-described compositions are mixed immediately prior to use and a sufficient amount of the mixture is applied to the hair, according to the hair abundance, generally from 60 to 200 grams. Upon such preparation the hair dye composition is applied to the hair to be dyed and remains in contact with the hair for an amount of time effective to dye the hair.
  • the hair dye composition is allowed to act on the hair for 2 to 60, preferably 15 to 45, more preferably, 30 minutes, at a temperature ranging from 15° to 50°C. Thereafter, the hair is rinsed with water, to remove the hair dye composition and dried. If necessary, the hair is washed with a shampoo and rinsed, e.g., with water or a weakly acidic solution, such as a citric acid or tartaric acid solution, and dried. Optionally, a separate conditioning product may also be provided. Together, components of the keratin dyeing composition form a system for dyeing hair. This system may be provided as a kit comprising in a single package separate containers of the keratin dyeing composition components or other hair treatment product, and instructions for use.
  • compositions of the present invention are non-limiting examples of the compositions of the present invention.
  • the examples are given solely for the pu ⁇ ose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention, which would be recognized by one of ordinary skill in the art.
  • all concentrations are listed as weight percent, unless otherwise specified.
  • the following compositions can be used for dyeing hair. Mix the dyeing composition with an equal weight of a 20-volume hydrogen peroxide solution (6% by weight). Apply the resulting mixture to the hair and permit it to remain in contact with the hair for 30 minutes. Shampoo dyed hair and rinse with water and dry. Common base (CB) for dyeing

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Abstract

Bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms. This invention further relates to a composition for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and one or more bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms. This invention further relates to a method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.

Description

KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF
FIELD OF INVENTION This invention relates to bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms, compositions for the oxidative dyeing of keratin fibers (preferably hair) comprising such compounds, and use thereof. BACKGROUND OF THE INVENTION The most extensively used method currently employed to color hair is by an oxidative process that utilizes one or more oxidative hair coloring agents in combination with one or more oxidizing agents. Commonly, a peroxy oxidizing agent is used in combination with one or more developers or couplers, generally small molecules capable of diffusing into hair. In this procedure, a peroxide material, such as hydrogen peroxide, activates the developers so that they react with the couplers to form larger sized compounds in the hair shaft to give a variety of shades and colors. A wide variety of developers and couplers have been employed in such oxidative hair coloring systems and compositions. However, there still exists a need for additional keratin dyeing compounds that can act as both developers and couplers that safely provide color benefits. SUMMARY OF THE INVENTION This invention relates to bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms according to the formulas defined herein. This invention also relates to a composition for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and one or more bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms. This invention further relates to a method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration. The keratin dyeing compounds of the present invention can act as both a developer and a coupler. It is to be understood that within the scope of this invention, numerous potentially and actually tautomeric compounds are involved. Thus, for example, 2-mercaptopyridine (I) exists under known conditions in the pyridine-2-thione tautomer form (II). It is to be understood that when this development refers to a particular structure, all of the reasonable additional tautomeric structures are included. In the art, tautomeric structures are frequently represented by one single structure and the present invention follows this general practice.
(I) (II) DETAILED DESCRIPTION OF THE INVENTION While the specification concludes with claims that particularly point out and distinctly claim the invention, it is believed the present invention will be better understood from the following description. The present invention relates to bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms. The compounds of the present invention can act as both developers and/or couplers that safely provide color benefits. Herein, "comprising" means that other steps and other ingredients which do not affect the end result can be added. This term encompasses the terms "consisting of and "consisting essentially of. The compounds/compositions and methods/processes of the present invention can comprise, consist of, and consist essentially of the essential elements and limitations of the invention described herein, as well as any of the additional or optional ingredients, components, steps, or limitations described herein. All percentages, parts and ratios are based upon the total weight of the compositions of the present invention, unless otherwise specified. All such weights as they pertain to listed ingredients are based on the active level and, therefore do not include solvents or by-products that may be included in commercially available materials, unless otherwise specified. The term "weight percent" may be denoted as "wt. %" herein. Except as otherwise noted, all amounts including part, percentages, and proportions are understood to be modified by the word "about", and amounts are not intended to indicate significant digits. Except as otherwise noted, the articles "a", "an", and "the" mean "one or more". As used herein, the term "keratin" refers to a scleroprotein found in epidermal tissues and modified into hard structures such as horns, hair, and nails. Thus, "keratinous fibers" refers to those found in hair, skin and nails and various animal body parts such as horns, hooves and feathers. As used herein, the term "hair" refers to keratinous fibers on a living, e.g. a person, or non-living body, e.g. in a wig, haiφiece, or other aggregation of non-living keratinous fibers. Mammalian, preferably human, hair is a preferred. Notably, hair, wool, fur, and other keratinous fibers are suitable substrates for coloring by the compounds and compositions described herein. As used herein, the term "keratin dyeing compounds" refers to compounds that may be used in the composition to act as developers, couplers, or both, in order to provide color to ketatinous fibers. As used herein, the term "keratin dyeing composition" refers to the composition containing one or more keratin dyeing compounds, including the compounds described herein. As used herein, "cosmetically acceptable" means that ingredients which the term describes are suitable for use in contact with the skin or hair of humans and lower animals without undue toxicity, incompatibility, instability, irritation, allergic response, and the like. I. Keratin dyeing Compounds The inventive compounds are bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms relating to the following compounds:
wherein Y and Z are independently selected from the group consisting of NA1, S and O; wherein R1, R2, R3, and R4 are the same or different and are selected from the group consisting of: (a) C-linked monovalent substituents selected from the group consisting of: (i) substituted or unsubstituted, straight or branched, alkyl, mono- or poly- unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefmic systems, (ii) substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems, and (iii) substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems; wherein said systems of (i), (ii) and (iii) comprise from about 1 to about 10 carbon atoms and from about 0 to about 5 heteroatoms selected from the group consisting of O, S, N, P, and Si; wherein substituents of the substituted systems of the C-linked monovalent substituents are selected from the group consisting of amino, hydroxyl, alkylamino (linear, branched, or cyclic C1-C5), dialkylamino (linear, branched, or cyclic C1-C5), hydroxyalkylamino (linear, branched, or cyclic C1-C5), dihydroxyalkylamino (linear, branched, or cyclic C1-C5), arylamino or substituted arylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), heteroarylamino or substituted heteroarylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1 -C5 alkylamino), arylmethylamino or substituted arylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), and heteroarylmethylamino or substituted heteroarylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino),
(b) S-linked monovalent substituents selected from the group consisting of SA1, SO3A!, SSA1, SOA1, SO2NA'A2, SNA1 A2, and SONA'A2;
(c) O-linked monovalent substituents selected from the group consisting of OA1, and ONA A2;
(d) N-linked monovalent substituents selected from the group consisting of NA'A2, (NA'A2A3)+, NA'OA2, NA'SA2, NO2, N=NA], N-NOA1, NA'CN, and NA'NA A3;
(e) monovalent substituents selected from the group consisting of COO A1, CONA'2, CONA'COA2, C(=NA')NA'A2, CN, and X; (f) fluoroalkyl monovalent substituents selected from the group consisting of mono-, poly-, and per-fiuoro alkyl systems comprising from about 1 to about 12 carbon atoms and from about 0 to about 4 heteroatoms; and (g) hydrogen 1 ^ wherein A , A , and A are monovalent and are independently selected from the group consisting of: H; substituted or unsubstituted, straight or branched, alkyl, mono- or poly-unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefinic systems; substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems; and substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems, or A1 and A2 together with nitrogen atom to which they are bound form a ring; wherein said systems comprise from about 1 to about 10 carbon atoms and from about 0 to about 5 heteroatoms selected from the group consisting of O, S, N, P, and Si; wherein X is a halogen selected from the group consisting of F, CI, Br, and I. In a preferred embodiment, R1, R2, R3, and R4 are selected from the group consisting of a hydrogen atom; a halogen atom such as chlorine, bromine or fluorine; an amino substituent, a hydroxyl substituent; a cyano substituent; a Cj-C alkyl substituent; a trifluoromethyl substituent, an alkylamino substituent (e.g., N,N-dimethylamino, N,N- diethylamino, N-methylamino, or N-ethylamino); a hydroxyalkylamino substituent (e.g., N-(hydroxyethyl)amino, N-hydroxymethylamino, N-hydroxypropylarnino, N,N- bis(hydroxyethyl)amino, N-(2,3-dihydroxypropyl)amino or N,N- bis(hydroxypropyl)amino); an acetylamido substituent; a carboxyl substituent or its esters; an alkoxy substituent (e.g., methoxy, ethoxy, propyloxy, benzyloxy, methoxyethoxy, phenoxyethoxy, 2-cyanoethoxy, phenethyloxy, phenoxyethoxy, p- chlorobenzyloxy or methoxy ethylcarbamoylmethoxy); an alkoxyalkyl substituent (e.g., methoxymethyl, methoxyethyl, methoxypropyl, ethoxymethyl, ethoxyethyl or ethoxypropyl); a carbamoyl substituent; an alkylcarbamoyl substituent (e.g., methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, or diethylcarbamoyl); a hydroxyalkylcarbamoyl substituent (e.g., 2-hydroxyethylcarbamoyl, bis(2- hydroxyethyl)carbamoyl, hydroxymethylcarbamoyl, bis(hydroxymethyl)carbamoyl); an amido substituent; an alkylamido substituent (e.g., acetamido, propionamido, or butyramido); an alkylcarbonyl substituent (e.g., acetyl, butyryl, or propionyl), an alkoxycarbonyl substituent (e.g., methoxycarbonyl, ethoxycarbonyl, or propoxycarbonyl); an aryloxy substituent (e.g., phenoxy, 4-methoxyphenoxy, 4-nitrophenoxy, 4- cyanophenoxy, 4-methanesulfonamidophenoxy, 4-methanesulfonylphenoxy, 3- methylphenoxy or 1-naphthyloxy); an acyloxy substituent (e.g., acetoxy, propanoyloxy, benzolyloxy, 2,4-dichlorobenzolyloxy, ethoxyalkyloxy, pyruviloyloxy, cinnamoyloxy or myristoyloxy); an alkylthio substituent (e.g., methylthio, ethylthio, propylthio, butylthio, 2-cyanoethylthio, benzylthio, phenethylthio, 2-(diethylamino)ethylthio, ethoxyethylthio or phenoxy ethylthio); an arylthio substituent (e.g., phenylthio, 4-carboxyphenylthio, 2- ethoxy-5-tert-butylphenylthio, 2-carboxyphenylthio or 4-methanesulfonylphenylthio); a heteroarylthio substituent (e.g., 5-phenyl-2,3,4,5-tetrazolyloxy or 2-benzothiazolyloxy); a heteroaryloxy substituent (e.g., 5-phenyl-2,3,4,5-tetrazolyloxy or 2-benzothiazolyloxy); a 3-, 4-, 5-, 6-, or 7- membered heterocycle having at least one nitrogen, oxygen or sulfur atom (e.g., pyridyl, quinolyl, morpholyl, fiiryl, tetrahydro furyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, imidazolyl, thiadiazolyl, pyrollidine, piperidine, moφholine, piperazine, indoline, hexahydroazepine, aziridine, and azetidine) and being optionally substituted; an aryl substituent (e.g., phenyl or naphthyl) which is optionally substituted; a sulfonyl substituent; a sulfinyl substituent; a phosphonyl substituent; a sulfamoyl substituent; a siloxy substituent; an acyloxy substituent; a carbamoyloxy substituent; a sulphonamide substituent; an imide substituent; a ureido substituent; a sulfamoylamino substituent; an alkoxycarbonylamino substituent; an aryloxycarbonylamino substituent; an aryloxycarbonyl substituent; and a benzenesulfonamido substituent. If the compound of the present invention is utilized as a developer, at least one of Rl, R2, R3, or R4 is an amino group, with at least one of the remaining Rl, R2, R3 or R4 substitutent preferably being selected from the group consisting of Amino, hydroxyl, a 3-, 4-, 5-, 6-, or 7- membered heterocycle having at least one nitrogen, oxygen or sulfur atom (e.g., pyridyl, quinolyl, moφholyl, furyl, tetrahydrofuryl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, imidazolyl, thiadiazolyl, pyrollidine, piperidine, moφholine, piperazine, indoline, hexahydroazepine, aziridine, and azetidine) and being optionally substituted, Alkylamino (linear, branched, or cyclic C1-C5), Dialkylamino (linear, branched, or cyclic C1-C5), Hydroxyalkylamino (linear, branched, or cyclic C1-C5), Dihydroxyalkylamino (linear, branched, or cyclic C1-C5), Arylamino or substituted arylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), Heteroarylamino or substituted heteroarylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), Arylmethylamino or substituted arylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), and Heteroarylmethylamino or substituted heteroarylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino). If the compound of the present invention is utilized as a coupler, preferably substituents are selected from the group consisting of Amino, Hydroxyl, Alkylamino (linear, branched, or cyclic C1-C5), Hydroxyalkylamino (linear, branched, or cyclic C l - C5), Arylamino or substituted arylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, CI -C5 alkylamino), Heteroarylamino or substituted heteroarylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), Arylmethylamino or substituted arylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), and Heteroarylmethylamino or substituted heteroarylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino). The developers and couplers of the present invention can also accommodate nucleofugic leaving groups selected from the group consisting of hydrogen, chlorine, cyano, alkoxy, phenoxy, methylsulfonyoxy, pyridone and pyridazone. In a preferred embodiment, the couplers of the present invention are utilized in compositions together with suitable 5-membered ring developers chosen from the following classes: thiophenes, pyrroles, furans, pyrazoles, imidazoles, thiazoles, oxazoles, isothiazoles, or isoxazoles. In a more preferred embodiment, the couplers of the present invention are utilized in compositions together with pyrazoles. In an even more preferred embodiment, the couplers of the present invention are utilized in compositions together with the following pyrazoles: 1 -methyl- lH-pyrazole-4,5-diamine, 2-(4,5-diamino- lH-pyrazol- l-yl)ethanol, 1 -isopropyl- lH-pyrazole-4,5-diamine, 1 -(4- methylbenzyl)-lH-pyrazole-4,5-diamine, l-(benzyl)-lH-pyrazole-4,5-diamine, l-(4- chlorobenzyl)-lH-pyrazole-4,5-diamine and l-Hydroxyethyl-4,5-diaminopyrazole sulphate. Even more preferably, the couplers of the present invention are utilized in compositions together with l-methyl-lH-pyrazole-4,5-diamine; 1 -Hydroxy ethyl-4, 5- diaminopyrazole sulphate; and 2-(4,5-diamino-lH-pyrazol-l-yl)ethanol. While not being bound to theory, such combinations enable the achievement of desired more hypsochromic colors (e.g., yellow) relative to conventional combinations of developers and couplers. Preferred developers and couplers include the following compounds with two or three heteroatoms: A. Bicyclic Fused 5-5 Heteroaromatic Compounds With Two Heteroatoms Bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two heteroatoms are selected from the group consisting of Pyrrolopyrroles, Furopyrroles, Thienopyrroles, Furofurans, Thienofurans, Thienothiophenes, and substitutions thereof. 1. Pyrrolopyrroles a. Preferred Developers Preferred developers are selected from the group consisting of 1,4-dihydro- pyrrolo[3,2-b]pyrrole-2,5-diamine, N'2'-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5- diamine, N'2'-ethyl- 1 ,4-dihydro-pyrrolo[3,2-b]pyrroIe-2,5-diamine, 2-(5-amino- 1 ,4- dihydro-pyrrolo[3 ,2-b]pyrrol-2-ylamino)-ethanol, 2-[(5-Amino- 1 ,4-dihydro-pyrrolo[3 ,2- b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-l,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ylamine, l-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diamine, l,N'5'-dimethyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diamine, N'5'-ethyl-l -methyl- 1,4- dihydro-pyrrolo[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-4-methyl-l,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ylamino)-ethanol, 2-[(5-amino-4-methyl-l,4-dihydro-pyrrolo[3,2- b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 1 -methyl-5-pyrrolidin- 1 -yl- 1 ,4-dihydro- pyrrolo[3 ,2-b]pyrrol-2-ylamine, 3-methyl- 1 ,4-dihydro-pyrrolo[3 ,2-b]pyrrole-2,5-diamine, 3-ethyl-N,2'-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-2- ethylamino-1 ,4-dihydro-pyrrolo[3,2-b]pyrrol-3-yl)-ethanol, 2-(5-amino-3-methoxy-l ,4- dihydro-pyrrolo[3 ,2-b]pyrrol-2-ylamino)-ethanol, 2-[(5 -amino-3 -chloro- 1 ,4-dihydro- pyrrolo[3,2-b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 6-ethoxy-5-pyιτolidin- 1 -yl- l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-ylamine, l,3,4-trimethyl-l,4-dihydro-pyrrolo[3,2- b]pyrrole-2,5-diamine, 2-(5-amino-3-ethyl-4-methyl-2-methylamino-4H-pyrrolo[3,2- bjpyrrol- 1 -yl)-ethanol, 2-(5-amino-2-ethylamino- 1 -isopropyl-4-methyl- 1 ,4-dihydro- pyrrolo[3,2-b]pyrrol-3-yl)-ethanol, l-[5-amino-2-(2-hydroxy-ethylamino)-3-methoxy-4- methyl-4H-pyrrolo[3 ,2-b]pyrrol- 1 -yl]-ethanone, 6-chloro- 1 ,4-dimethyl-5-pyrrolidin- 1 -yl- l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-ylamine, 5-amino-l,4-dihydro-pyrrolo[3,2-b]pyrrol-2- ol, 4,5,6,7-tetrahydro-lH-l,3b,7-triaza-cyclopenta[a]inden-2-ylamine, 1,2,3,6-tetrahydro- 1 ,3a,6-triaza-cyclopenta[a]pentalen-5-ylamine, 2-(5-amino-2,3-dihydro-6H- 1 ,3a,6-triaza- cyclopenta[a]pentalen- 1 -yl)-ethanol, 1 -methy 1-4,5 ,6,7-tetrahydro- 1 H- 1 ,3b,7-triaza- cyclopenta[a]inden-2-ylamine, 6-ethyl- 1 ,2,3 ,6-tetrahydro- 1 ,3a,6-triaza- cyclopenta[a]pentalen-5-ylamine, and 2-[5-amino-6-(2-hydroxy-ethyl)-2,3-dihydro-6H- 1 ,3a,6-triaza-cyclopenta[a]pentalen- l-yl]-ethanol. Especially preferred developers of the present invention are selected from the group consisting of l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-l,4- dihydro-pyrrolo[3 ,2-b]pyrrol-2-ylamino)-ethanol, 2-[(5-Amino- 1 ,4-dihydro-pyrrolo[3 ,2- b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin- 1 -yl- 1 ,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ylamine, l-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-4-methyl- 1 ,4-dihydro-pyrrolo[3,2-b]pynOl-2-ylamino)-ethanol, 2-[(5-amino- 4-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, and 1 -methyl-5-pyrrolidin- 1 -yl- 1 ,4-dihydro-pyrrolo[3 ,2-b]pyrrol-2-ylamine. b. Preferred Couplers Preferred couplers are selected from the group consisting of 1,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ol, l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-ylamine, 3-chloro-l,4- dihydro-pyrrolo[3,2-b]pyrrol-2-ol, 3-methoxy-l,4-dihydro-pyrrolo[3,2-b]pyrrol-2- ylamine, 1 ,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diol, 1 ,4-dimethyl- 1 ,4-dihydro- pyrrolo[3,2-b]pyrrol-2-ol, 5-amino-l,4-dimethyl-l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-ol, 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3 ,2-b]pyrrol-2-ylamine, 1 ,4-dimethyl- 1 ,4-dihydro- pyrrolo[3,2-b]pyrrole-2,5-diamine, l,4-dihydro-pyrrolo[3,2-b]pyrrole, 2,5-dimethyl-l,4- dihydro-pyrrolo[3 ,2-b]pyrrole, 3,6-dimethyl- 1 ,4-dihydro-pyrrolo[3 ,2-b]pyrrole, 1 ,4- dihydro-pyrrolo[3,2-b]pyrrole-3,6-diol, 3-methyl-l ,4-dihydro-pyrrolo[3,2-b]pyrrole, 2- methyl- 1 ,4-dihydro-pyrrolo[3,2-b]pyrrole, 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3,2- b]pyrrole, 1 ,2,4,5-tetramethyl- 1 ,4-dihydro-pyrrolo[3 ,2-b]pyrrole, 1 ,3 ,4,6-tetramethyl- 1 ,4- dihydro-pyrrolo[3,2-b]pyrrole, l,4-dimethyl-l,4-dihydro-pyrrolo[3,2-b]pynOle-3,6-diol, l,2,4-trimethyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole, l,3,4-trimethyl-l,4-dihydro- pyrrolo[3,2-b]pyrrole, 1 ,4-dihydro-2-methoxy-pyrrolo[3,2-b]pyrrole, 1 ,4-dihydro-2- ethoxy-pyrrolo[3,2-b]pyrrole, l,4-dimethyl-l,4-dihydro-2-methoxy-pyrrolo[3,2- b]pyrrole, 1 ,4-dimethyl- 1 ,4-dihydro-2-ethoxy-pyrrolo [3 ,2-b]pyrrole, ( 1 ,4- dihydropyιτolo[3,2-b]pyrrol-5-yl)methanol, 2-(l,4-dihydropyrrolo[3,2-b]pyrrol-5- yl)ethanol, (l,4-dihydro-l,4-dimethylpyrrolo[3,2-b]pyrrol-5-yl)methanol, and 2-(l,4- dihydro-l,4-dimethylpyrrolo[3,2-b]pyrrol-5-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of l,4-dihydro-pyrrolo[3,2-b]pyrrol-2-ol, l,4-dihydro-pyrrolo[3,2-b]pyrrol-2- ylamine, l,4-dihydro-pyrrolo[3,2-b]pyrrole-2,5-diol, l,4-dihydro-pyrrolo[3,2-b]pyrrole, 2,5-dimethyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole, l,4-dihydro-pyrrolo[3,2-b]pyrrole-3,6- diol, 2-methyl-l,4-dihydro-pyrrolo[3,2-b]pyrrole, and (l,4-dihydropyrrolo[3,2-b]pyrrol- 5-yl)methanol. 2. Furopyrroles a. Preferred Developers Preferred developers are selected from the group consisting of 4H-furo[3,2- b]pyiTole-2,5-diamine, N,2'-methyl-4H-furo[3,2-b]pyrrole-2,5-diamine, N'2'-ethyl-4H- furo[3 ,2-b]pyrrole-2,5-diamine, 2-(5-amino-4H-furo[3 ,2-b]pyrrol-2-ylamino)-ethanol, 2- [(5-amino-4H-furo[3,2-b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin-l- yl-4H-furo[3,2-b]pyrrol-5-ylamine, 4-methyl-4H-furo[3,2-b]pyrrole-2,5-diamine, 4-ethyl- N'2'-methyl-4H-furo[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-2-ethylamino-furo[3,2- b]pyrrol-4-yl)-ethanol, 2-(5-amino-4-isopropyl-4H-furo[3,2-b]pyrrol-2-ylamino)-ethanol, 2-[(5-amino-4-methyl-4H-furo[3,2-b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 4- methyl-2-pyrrolidin-l-yl-4H-furo[3,2-b]pyrrol-5-ylamine, N'5'-methyl-4H-furo[3,2- b]pyrrole-2,5-diamine, N'5'-ethyl-4H-furo[3,2-b]pyrrole-2,5-diamine, 2-(2-amino-4H- furo[3,2-b]pyrrol-5-ylamino)-ethanol, 2-[(2-amino-4H-furo[3,2-b]pyrrol-5-yl)-(2- hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-4H-furo[3,2-b]pyrrol-2-ylamine, 3- methyl-4H-furo[3,2-b]pyrrole-2,5-diamine, 3,N'5'-diethyl-4H-furo[3,2-b]pyrrole-2,5- diamine, 2-(2-amino-3-methoxy-4H-furo[3,2-b]pyrrol-5-ylamino)-ethanol, 2-amino-5- [bis-(2-hydroxy-ethyl)-amino]-4H-furo[3,2-b]pyrrole-3-carbonitrile, 4,5,6,7-tetrahydro-l- oxa-3b,7-diaza-cyclopenta[a]inden-2-ylamine, 2,3-dihydro-lH-6-oxa-l,3a-diaza- cyclopenta[a]pentalen-5-ylamine, 2-(5-amino-2,3-dihydro-6-oxa- 1 ,3a-diaza- cyclopenta[a]pentalen-l-yl)-ethanol, 5-amino-4H-furo[3,2-b]pyrrol-2-ol, and 2-amino- 4H-furo[3,2-b]pyrrol-5-ol Especially preferred developers of the present invention are selected from the group consisting of 4H-furo[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-4H-furo[3,2-b]pyrrol- 2-ylamino)-ethanol, 2-[(5-amino-4H-furo[3,2-b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin-l-yl-4H-furo[3,2-b]pyrrol-5-ylamine, 4-methyl-4H-furo[3,2- b]pyrrole-2,5-diamine, 2-[(5-amino-4-methyl-4H-furo[3,2-b]pyrrol-2-yl)-(2-hydroxy- ethyl)-amino]-ethanol, and 4-methyl-2-pyrrolidin-l-yl-4H-furo[3,__-t-b]pyrrol-5-ylamine. b. Preferred Couplers Preferred couplers are selected from the group consisting of 4H-furo[3,2-b]pyrrol- 2-61, 4H-furo[3,2-b]pyrrol-5-ol, 4H-furo[3,2-b]pyrrol-5-ylamine, 4H-furo[3,2-b]pyrrol-2- ylamine, 4-methyl-4H-furo[3,2-b]pyrrol-2-ol, 4-methyl-4H-furo[3,2-b]pyrrol-5-ol, 4- methyl-4H-furo[3,2-b]pyrrol-2-ylamine, 4-methyl-4H-furo[3,2-b>]pyrrol-5-ylamine, 3- chloro-4H-furo[3,2-b]pyrrol-2-ol, 3-chloro-4-methyl-4H-furo[3,2-b]pyrrol-2-ol, 6-chloro- 4H-furo[3,2-b]pyrrol-5-ol, 6-chloro-4-methyl-4H-furo[3,2-b]pyrrol-5-ol, 5,6-dihydro-4H- l,7-dioxa-3b-aza-cyclopenta[a]inden-2-ylamine, 3-amino-4H-fiιro[3,2-b]pyrrol-5-ol, 3- methoxy-4H-furo[3 ,2-b]pyrrol-2-ylamine, 6-methoxy-4H-mroπ 3 ,2-b]pyrrol-5-ylamine, 4H-furo[3,2-b]pyrrole-2,5-diol, 5-amino-4-methyl-4H-furo[3,2-b] yrrol-2-ol, 2-amino-4- methyl-4H-furo[3,2-b]pyrrol-5-ol, 5-amino-4H-furo[3,2-b]pyrr l-2-ol, 2-amino-4H- furo[3,2-b]pyrrol-5-ol, 4H-furo[3,2-b]pyrrole, 2,5-dimethyl-4H-furo[3,2-b]pyrrole, 3,6- dimethyl-4H-furo[3,2-b]pyrrole, 4H-furo[3,2-b]pyrrole-3,6-diol, 3-methyl-4H-furo[3,2- bjpyrrole, 6-methyl-4H-furo[3,2-b]pyrrole, 2-methyl-4H-furo[3--2-b]pyrrole, 5-methyl- 4H-furo[3,2-b]pyrrole, 4-methyl-4H-furo[3,2-b]pyrrole, 2,4,5 -trimethyl-4H-furo[3,2- bjpyrrole, 3,4,6-trimethyl-4H-furo[3,2-b]pyrrole, 4-methyl-4H-furo[3,2-b]pyrrole-3,6- diol, 2,4-dimethyl-4H-furo[3,2-b]pyrrole, 4,5-dimethyl-4H-fiιro[3,2-b]pyrrole, 3,4- dimethyl-4H-furo[3 ,2-b]pyrrole, 4,6-dimethyl-4H-furo[3 ,2-b]py role, 2-methoxy-4H- furo[3,2-b]pyrrole, 5-methoxy-4H-furo[3,2-b]pyrrole, 2-ethoxy-4H-furo[3,2-b]pyrrole, 5- ethoxy-4H-furo[3,2-b]pyrrole, 5-methoxy-4-methyl-4H-furo[3,2-bι]pyrrole, 2-methoxy-4- methyl-4H-furo[3,2-b]pyrrole, (4H-furo[3,2-b]pyrrol-2-yl)metlιanol, (4H-furo[3,2- b]pyrrol-5-yl)methanol, 2-(4H-furo[3,2-b]pyrrol-5-yl)ethanol, 2-C4H-furo[3,2-b]pyrrol-2- yl)ethanol, (4-methyl-4H-furo[3,2-b]pyrrol-2-yl)methanol, and (4-methyl-4H-furo[3,2- b]pyrrol-5-yl)methanol. Especially preferred couplers are selected from the group consisting of 4H- furo[3,2-b]ρyrrol-2-ol, 4H-furo[3,2-b]pyrrol-5-ol, 4H-furo[3,2-b]pyrrol-5-ylamine, 4H- furo[3,2-b]pyrrole-2,5-diol, 4H-furo[3,2-b]pyrrole, 2,5-dimethyl-4H-furo[3,2-b]pyrrole, 3,6-dimethyl-4H-furo[3,2-b]pyrrole, 4H-furo[3,2-b]pyrrole-3,6-diol, 2-methyl-4H- furo[3,2-b]pyrrole, 5-methyl-4H-furo[3,2-b]pyrrole, (4H-furo[3,2-b]pyrrol-2-yl)methanol, and (4H-furo[3,2-b]pyrrol-5-yl)methanol. 3. Thienopyrroles a. Preferred Developers Preferred developers are selected from the group consisting of 4H-thieno[3,2- b]pyrrole-2,5-diamine, N'2'-methyl-4H-thieno[3,2-b]pyrrole-2,5-diamine, N'2'-ethyl-4H- thieno[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-4H-thieno[3,2-b]pyrrol-2-ylamino)- ethanol, 2-[(5-amino-4H-thieno[3,2-b]pyrrol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2- pyrrolidin-l-yl-4H-thieno[3,2-b]pyιiOl-5-ylamine, 4-methyl-4H-thieno[3,2-b]pyrrole-2,5- diamine, 4-ethyl-N'2'-methyl-4H-thieno[3,2-b]pyrrole-2,5-diamine, (5-amino-2- ethylamino-thieno[3,2-b]pyrrol-4-yl)-methanol, 2-(5-amino-4-isopropyl-4H-thieno[3,2- b]pyrrol-2-ylamino)-ethanol, 2-[(5-amino-4-methyl-4H-thieno[3,2-b]pyrrol-2-yl)-(2- hydroxy-ethyl)-amino]-ethanol, 4-methyl-2-pyrrolidin-l-yl-4H-thieno[3,2-b]pyrrol-5- ylamine, N'5'-methyl-4H-thieno[3,2-b]pyrrole-2,5-diamine, N'5'-ethyl-4H-thieno[3,2- b]pyrrole-2,5-diamine, 2-(2-amino-4H-thieno[3,2-b]pyrrol-5-ylamino)-ethanol, 2-[(2- amino-4H-thieno[3,2-b]pyrrol-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin- 1 -yl- 4H-thieno[3,2-b]pyrrol-2-ylamine, 3,4-dimethyl-4H-thieno[3,2-b]pyrrole-2,5-diamine, 3- ethyl-4,N'5'-dimethyl-4H-thieno[3,2-b]pyrrole-2,5-diamine, 2-(2-amino-3-methoxy-4- methyl-4H-thieno[3,2-b]pyrrol-5-ylamino)-ethanol, 2-amino-5-[bis-(2-hydroxy-ethyl)- amino]-4H-thieno[3,2-b]pyrrole-3-carbonitrile, 4,5,6,7-tetrahydro-l-thia-3b,7-diaza- cyclopenta[a]inden-2-ylamine, 2,3-dihydro-lH-6-thia-l,3a-diaza-cyclopenta[a]pentalen- 5-ylamine, 2-(5-amino-2,3-dihydro-6-thia- 1 ,3a-diaza-cyclopenta[a]pentalen- 1 -yl)- ethanol, 5-amino-4H-thieno[3,2-b]pyrrol-2-ol, and 2-amino-4H-thieno[3,2-b]pyrrol-5-ol. Especially preferred developers of the present invention are selected from the group consisting of 4H-thieno[3,2-b]pyrrole-2,5-diamine, 2-(5-amino-4H-thieno[3,2- b]pyrrol-2-ylamino)-ethanol, 2-[(5-amino-4H-thieno[3,2-b]pyrrol-2-yl)-(2-hydroxy- ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl-4H-thieno[3,2-b]pyrrol-5-ylamine, 4-methyl-4H- thieno[3,2-b]pyrrole-2,5-diamine, 2-[(5-amino-4-methyl-4H-thieno[3,2-b]pynOl-2-yl)-(2- hydroxy-ethyl)-amino]-ethanol, and 4-methyl-2-pyrrolidin-l-yl-4H-thieno[3,2-b]pyrrol-5- ylamine. b. Preferred Couplers Preferred couplers are selected from the group consisting of 4H-thieno[3,2- b]pyrrol-2-ol, 4H-thieno[3,2-b]pyrrol-5-ol, 4H-thieno[3,2-b]pyrrol-5-ylamine, 4H- thieno[3,2-b]pyrrol-2-ylamine, 4-methyl-4H-thieno[3,2-b]pyrrol-2-ol, 4-methyl-4H- thieno[3,2-b]pyrrol-5-ol, 4-methyl-4H-thieno[3,2-b]pyrrol-2-ylamine, 4-methyl-4H- thieno[3,2-b]pyrrol-5-ylamine, 3-chloro-4H-thieno[3,2-b]pyrrol-2-ol, 3-chloro-4-methyl- 4H-thieno[3,2-b]pyrrol-2-ol, 6-chloro-4H-thieno[3,2-b]pyrrol-5-ol, 6-chloro-4-methyl- 4H-thieno[3,2-b]pyrrol-5-ol, 5,6-dihydro-4H-l,7-dioxa-3b-aza-cyclopenta[a]inden-2- ylamine, 3-amino-4H-thieno[3,2-b]pyrrol-5-ol, 3-methoxy-4H-thieno[3,2-b]pyrrol-2- ylamine, 6-methoxy-4H-thieno[3,2-b]pyrrol-5-ylamine, 4H-thieno[3,2-b]pyrrole-2,5-diol, 5-amino-4-methyl-4H-thieno[3,2-b]pyrrol-2-ol, 2-amino-4-methyl-4H-thieno[3,2- b]pyrrol-5-ol, 5-amino-4H-thieno[3,2-b]pyrrol-2-ol, 2-amino-4H-thieno[3,2-b]pyrrol-5- ol, 4H-thieno[3,2-b]pyrrole, 2,5-dimethyl-4H-thieno[3,2-b]pyrrole, 3,6-dimethyl-4H- thieno[3,2-b]pyrrole, 4H-thieno[3,2-b]pyrrole-3,6-diol, 3-methyl-4H-thieno[3,2- bjpyrrole, 6-methyl-4H-thieno[3,2-b]pyrrole, 2-methyl-4H-thieno[3,2-b]pyrrole, 5- methyl-4H-thieno[3,2-b]pyrrole, 4-methyl-4H-thieno[3,2-b]pyrrole, 2,4,5-trimethyl-4H- thieno[3,2-b]pyrrole, 3,4,6-trimethyl-4H-thieno[3,2-b]pyrrole, 4-methyl-4H-thieno[3,2- b]pyrrole-3 ,6-diol, 2,4-dimethyl-4H-thieno[3 ,2-b]pyrrole, 4,5-dimethyl-4H-thieno[3 ,2- b]pyrrole, 3,4-dimethyl-4H-thieno[3,2-b]pyrrole, 4,6-dimethyl-4H-thieno[3,2-b]pyrrole, 2-methoxy-4H-thieno[3,2-b]pyrrole, 5-methoxy-4H-thieno[3,2-b]pyrrole, 2-ethoxy-4H- thieno[3,2-b]pyrrole, 5-ethoxy-4H-thieno[3,2-b]pyrrole, 5-methoxy-4-methyl-4H- thieno[3,2-b]pyrrole, 2-methoxy-4-methyl-4H-thieno[3,2-b]pyrrole, (4H-thieno[3,2- b]pyrrol-2-yl)methanol, (4H-thieno[3 ,2-b]pyrrol-5-yl)methanol, 2-(4H-thieno[3 ,2- b]pynOl-5-yl)ethanol, 2-(4H-thieno[3,2-b]ρyrrol-2-yl)ethanol, (4-methyl-4H-thieno[3,2- b]pyrrol-2-yl)methanol, and (4-methyl-4H-thieno[3,2-b]pyrrol-5-yl)methanol. Especially preferred couplers of the present invention are selected from the group consisting of 4H-thieno[3,2-b]pyrrol-2-ol, 4H-thieno[3,2-b]pyrrol-5-ol, 4H-thieno[3,2- b]pyrrol-5-ylamine, 4H-thieno[3,2-b]pyrrole-2,5-diol, 4H-thieno[3,2-b]pyrrole, 2,5- dimethyl-4H-thieno[3,2-b]pyrrole, 3,6-dimethyl-4H-thieno[3,2-b]pyrrole, 4H-thieno[3,2- b]pyrrole-3,6-diol, 2-methyl-4H-thieno[3,2-b]pyrrole, 5-methyl-4H-thieno[3,2-b]pyrrole, (4H-thieno[3 ,2-b]pyrrol-2-yl)methanol, and (4H-thieno[3 ,2-b]pyrrol-5-yl)methanol. 4. Furofurans a. Preferred Developers Preferred developers are selected from the group consisting of furo[3,2-b]furan- 2,5-diamine, N,2'-methyl-furo[3,2-b]furan-2,5-diamine, N,2'-ethyl-furo[3,2-b]furan-2,5- diamine, 2-(5-amino-furo[3,2-b]furan-2-ylamino)-ethanol, 2-[(5-amino-furo[3,2-b]furan- 2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin- 1 -yl-furo[3 ,2-b]furan-2-ylamine, and 5-amino-furo[3,2-b]furan-2-ol. Especially preferred developers of the present invention are selected from the group consisting of furo[3,2-b]furan-2,5-diamine, N'2'-ethyl-furo[3,2-b]furan-2,5- diamine, 2-(5-amino-furo[3,2-b]furan-2-ylamino)-ethanol, 2-[(5-amino-furo[3,2-b]furan- 2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, and 5-pyrrolidin- 1 -yl-furo[3 ,2-b]furan-2- ylamine. a. Preferred Couplers Preferred couplers are selected from the group consisting of furo[3,2-b]furan-2-ol, furo[3,2-b]furan-2-ylamine, 3-chloro-furo[3,2-b]furan-2-ol, 3-methoxy-furo[3,2-b]furan- 2-ylamine, furo[3,2-b]furan-2,5-diol, furo[3,2-b]furan, 2,5-dimethyl-furo[3,2-b]furan, 3,6-dimethyl-mro[3,2-b]furan, furo[3,2-b]furan-3,6-diol, 3-methyl-furo[3,2-b]furan, 2- methyl-furo[3,2-b]furan, 2-methoxyfuro[3,2-b]furan, 2-ethoxyfuro[3,2-b]furan, (furo[3,2- b]furan-5-yl)methanol, and 2-(furo[3,2-b]furan-5-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of furo[3,2-b]furan-2-ol, furo[3,2-b]furan-2-ylamine, furo[3,2-b]furan-2,5-diol, furo[3,2-b]furan, 2,5-dimethyl-furo[3,2-b]furan, furo[3,2-b]furan-3,6-diol, 2-methyl- furo[3,2-b]furan, and (furo[3,2-b]furan-5-yl)methanol. 5. Thienofurans a. Preferred Developers Preferred developers are selected from the group consisting of thieno[3,2-b]furan- 2,5-diamine, N'5'-methyl-thieno[3,2-b]furan-2,5-diamine, N'5'-ethyl-thieno[3,2-b]furan- 2,5-diamine, 2-(2-amino-thieno[3,2-b]furan-5-ylamino)-ethanol, 2-[(2-amino-thieno[3,2- b]furan-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-thieno[3,2-b]furan-2- ylamine, N'2'-Methyl-thieno[3,2-b]furan-2,5-diamine, N'2'-ethyl-thieno[3,2-b]furan-2,5- diamine, 2-(5-amino-thieno[3,2-b]furan-2-ylamino)-ethanol, 2-[(5-amino-thieno[3,2- b]furan-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl-thieno[3 ,2-b]fiιran-5- ylamine, 5-amino-thieno[3,2-b]furan-2-ol, 2-amino-thieno[3,2-b]furan-5-ol, and 5-amino- 6-methyl-thieno[3,2-b]furan-2-ol. Especially preferred developers of the present invention are selected from the group consisting of thieno[3,2-b]furan-2,5-diamine, 2-(2-amino-thieno[3,2-b]furan-5~ ylamino)-ethanol, 2-[(2-amino-thieno[3,2-b]furan-5-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 5-pyrrolidin- l-yl-thieno[3,2-b]furan-2-ylamine, 2-(5-amino-thieno[3,2-b]furan- 2-ylamino)-ethanol, 2-[(5-amino-thieno[3,2-b]furan-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin-l-yl-thieno[3,2-b]furan-5-ylamine, and 5-amino-thieno[3,2-b]furan- 2-ol. a. Preferred Couplers Preferred couplers are selected from the group consisting of thieno[3,2-b]furan-2- ol, thieno[3,2-b]furan-5-ol, thieno[3,2-b]furan-5-ylamine, thieno[3,2-b]furan-2-ylamine, 3-chloro-thieno[3,2-b]furan-2-ol, 6-chloro-thieno[3,2-b]furan-5-ol, 3-amino-thieno[3,2- b]fixran-5-ol, 3-methoxy-thieno[3,2-b]furan-2-yIamine, 6-methoxy-thieno[3,2-b]furan-5- ylamine, thieno[3,2-b]furan-2,5-diol, 5-amino-thieno[3,2-b]furan-2-ol, 2-amino- thieno[3,2-b]furan-5-ol, thieno[3,2-b]furan, 2,5-dimethyl-thieno[3,2-b]furan, 3,6- dimethyl-thieno[3,2-b]furan, thieno[3,2-b]furan-3,6-diol, 3-methyl-thieno[3,2-b]furan, 6- methyl-thieno[3,2-b]furan, 2-methyl-thieno[3,2-b]furan, 5-methyl-thieno[3,2-b]furan, 2- methoxy-thieno[3,2-b]furan, 5-methoxy-thieno[3,2-b]furan, 2-ethoxy-thieno[3,2-b]furan, 5-ethoxy-thieno[3,2-b]furan, (thieno[3,2-b]furan-2-yl)methanol, (thieno[3,2-b]furan-5- yl)methanol, 2-(thieno[3,2-b]furan-5-yl)ethanol, and 2-(thieno[3,2-b]furan-2-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of thieno[3,2-b]furan-2-ol, thieno[3,2-b]furan-5-ol, thieno[3,2-b]furan-5- ylamine, thieno[3,2-b]furan-2,5-diol, thieno[3,2-b]furan, 2,5-dimethyl-thieno[3,2-b]furan, 3,6-dimethyl-thieno[3,2-b]furan, thieno[3,2-b]furan-3,6-diol, 2-methyl-thieno[3,2- b]furan, 5-methyl-thieno[3,2-b]furan, (thieno[3,2-b]furan-2-yl)methanol, and (thieno[3,2- b]furan-5 -yl)methanol . 6. Thienothiophenes a. Preferred Developers Prefened developers are selected from the group consisting of thieno[3,2- b]thiophene-2,5-diamine, N'2'-methyl-thieno[3 ,2-b]thiophene-2,5-diamine, N'2'-ethyl- thieno[3 ,2-b]thiophene-2,5-diamine, 2-(5-amino-thieno[3 ,2-b]thiophen-2-ylamino)- ethanol, 2-[(5-amino-thieno[3,2-b]thiophen-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5- pyrrolidin-l-yl-thieno[3,2-b]thiophen-2-ylamine, 3-methoxy-thieno[3,2-b]thiophene-2,5- diamine, 3-thiophen-2-yl-thieno[3,2-b]thiophene-2,5-diamine, 3-thiazol-2-yl-thieno[3,2- b]thiophene-2,5-diamine, 3-(4-methoxy-phenyl)-thieno[3,2-b]thiophene-2,5-diamine, 3- methyl-thieno[3,2-b]thiophene-2,5-diamine, 2-(2,5-diamino-thieno[3,2-b]thiophen-3-yl)- ethanol, 3-(2,5-diamino-thieno[3,2-b]thiophen-3-yl)-propane-l ,2-diol, 5-amino- thieno[3,2-b]thiophen-2-ol, and 5-amino-6-methyl-thieno[3,2-b]thiophen-2-ol. Especially preferred developers of the present invention are selected from the group consisting of thieno[3,2-b]thiophene-2,5-diamine, 2-(5-amino-thieno[3,2- b]thiophen-2-ylamino)-ethanol, 2-[(5-amino-thieno[3,2-b]thiophen-2-yl)-(2-hydroxy- ethyl)-amino]-ethanol, 5-pyrrolidin- l-yl-thieno[3,2-b]thiophen-2-ylamine, and 5-amino- thieno[3,2-b]thiophen-2-ol. a. Preferred Couplers Preferred couplers are selected from the group consisting of thieno[3,2- b]thiophen-2-ol, thieno[3,2-b]thiophen-2-ylamine, 3-chloro-thieno[3,2-b]thiophen-2-ol, 3-methoxy-thieno[3,2-b]thiophen-2-ylamine, thieno[3,2-b]thiophen-2,5-diol, thieno[3,2- b]thiophene, 2,5-dimethyl-thieno[3,2-b]thiophene, 3,6-dimethyl-thieno[3,2-b]thiophene, thieno[3,2-b]thiophen-3,6-diol, 3-methyl-thieno[3,2-b]thiophene, 2-methyl-thieno[3,2- bjthiophene, 2-methoxythieno[3,2-b]thiophene, 2-ethoxythieno[3,2-b]thiophene, (thieno[3 ,2-b]thiophen-5-yl)methanol, and 2-(thieno[3 ,2-b]thiophen-5-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of thieno[3,2-b]thiophen-2-ol, thieno[3,2-b]thiophen-2-ylamine, thieno[3,2- b]thiophen-2,5-diol, thieno[3,2-b]thiophene, 2,5-dimethyl-thieno[3,2-b]thiophene, thieno[3,2-b]thiophen-3,6-diol, 2-methyl-thieno[3,2-b]thiophene, (thieno[3,2-b]thiophen- 5-yl)methanol, thieno[3,2-b]thiophene-2-carboxylic acid, thieno[3,2-b]thiophene-2- carboxamide, 5-methyl-thieno[3,2-b]thiophene-2-carboxylic acid, 3,5-diamino- thieno[3,2-b]thiophene-2,6-dicarbonitrile, N-hydroxy-N-(l-thieno[3,2-b]thien-2-ylethyl)- urea, N-hydroxy-N-(l-thieno[3,2-b]thien-2-ylmethyl)-urea, 2,5-bis(methylthio)- thieno[3,2-b]thiophene, and thieno[3,2-b]thiophene-2,5-dicarboxylic acid. B. Bicyclic Bused 5-5 Heteroaromatic Compounds With Three Heteroatoms Bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with three heteroatoms are selected from the group consisting of furooxazoles, pyrrolooxazoles, thienooxazoles, fliroimidazoles, pyrroloimidazoles, thienoimidazoles, furothiazoles, pyrrolothiazoles, thienothiazoles, furooxazoles, and substitutions thereof. 1. Furooxazoles a. Preferred Developers Preferred developers are selected from the group consisting of furo[2,3-d]oxazole- 2,5-diamine, N2-methyl-furo[2,3-d]oxazole-2,5-diamine, N2-ethyl-furo[2,3-d]oxazole- 2,5-diamine, 2-(5-amino-furo[2,3-d]oxazol-2-ylamino)-ethanol, 2-[(5-amino-furo[2,3- d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, N5-methyl-furo[2,3-d]oxazole-2,5- diamine, N5-ethyl-fiιro[2,3-d]oxazole-2,5-diamine, 2-(2-amino-furo[2,3-d]oxazol-5- ylamino)-ethanol, 2-[(2-amino-furo[2,3-d]oxazol-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin- l-yl-furo[2,3-d]oxazol-2-ylamine, 2-[(2-amino-furo[2,3-d]oxazol-5-yl)- ethyl-amino]-ethanol, 6-methyl-furo[2,3-d]oxazole-2,5-diamine, 2-(2,5-diamino-furo[2,3- d]oxazol-6-yl)-ethanol, 6-methoxy-furo[2,3-d]oxazole-2,5-diamine, 5-amino-furo[2,3- d]oxazol-2-ol, and 2-amino-mro[2,3-d]oxazol-5-ol. Especially preferred developers of the present invention are selected from the group consisting of furo[2,3-d]oxazole-2,5-diamine, 2-(5-amino-furo[2,3-d]oxazol-2- ylamino)-ethanol, 2-[(5-amino-furo[2,3-d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-(2-amino-furo[2,3-d]oxazol-5-ylamino)-ethanol, 2-[(2-amino-furo[2,3-d]oxazol-5-yl)- (2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-furo[2,3-d]oxazol-2-ylamine, 5- amino-furo[2,3-d]oxazol-2-ol, and 2-amino-furo[2,3-d]oxazol-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of furo[2,3-d]oxazol-2- ol, furo[2,3-d]oxazol-5-ol, furo[2,3-d]oxazol-5-ylamine, furo[2,3-d]oxazol-2-ylamine, 6- chloro-furo[2,3-d]oxazol-5-ol, 6-amino-furo[2,3-d]oxazol-5-ol, 6-amino-furo[2,3- d]oxazol-2-ol, 3-methoxy-furo[2,3-d]oxazol-2-ylamine, 6-methoxy-furo[2,3-d]oxazol-5- ylamine, furo[2,3-d]oxazol-2,5-diol, 5-amino-furo[2,3-d]oxazol-2-ol, 2-amino-furo[2,3- d]oxazol-5-ol, furo[2,3-d]oxazole, 2,5-dimethyl-furo[2,3-d]oxazole, 6-methyl-furo[2,3- djoxazole, 2-methyl-furo[2,3-d]oxazole, 5-methyl-furo[2,3-d]oxazole, 2-methoxy- furo[2,3-d]oxazole, 5-methoxy-furo[2,3-d]oxazole, 2-ethoxy-furo[2,3-d]oxazole, 5- ethoxy-furo[2,3-d]oxazole, (furo[2,3-d]oxazol-2-yl)methanol, (furo[2,3-d]oxazol-5- yl)methanol, 2-(furo[2,3-d]oxazol-5-yl)ethanol, and 2-(furo[2,3-d]oxazol-2-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of furo[2,3-d]oxazol-2-ol, furo[2,3-d]oxazol-5-ol, furo[2,3-d]oxazol-5- ylamine, furo[2,3-d]oxazol-2,5-diol, furo[2,3-d]oxazole, 2,5-dimethyl-furo[2,3-d]oxazole, 2-methyl-furo[2,3-d]oxazole, 5-methyl-furo[2,3-d]oxazole, (furo[2,3-d]oxazol-2- yl)methanol, and (furo[2,3-d]oxazol-5-yl)methanol. 2. Pyrrolooxazoles a. Preferred Developers Preferred developers are selected from the group consisting of 4H-l-oxa-3,4- diaza-pentalene-2,5-diamine, N2-methyl-4H-l-oxa-3,4-diaza-pentalene-2,5-diamine, N2- ethyl-4H- 1 -oxa-3 ,4-diaza-pentalene-2,5-diamine, 2-(5-amino-4H- 1 -oxa-3 ,4-diaza- pentalen-2-ylamino)-ethanol, 2-[(5-amino-4H-l-oxa-3,4-diaza-pentalen-2-yl)-(2- hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl-4H- 1 -oxa-3 ,4-diaza-pentalen-5 - ylamine, N5-methyl-4H- 1 -oxa-3 ,4-diaza-pentalene-2,5-diamine, N5-ethyl-4H- 1 -oxa-3 ,4- diaza-pentalene-2,5-diamine, 2-(2-amino-4H-l-oxa-3,4-diaza-pentalen-5-ylamino)- ethanol, 2-[(2-amino-4H-l-oxa-3,4-diaza-pentalen-5-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 5-pyrrolidin-l-yl-4H-l-oxa-3,4-diaza-pentalen-2-ylamine, 2-[(2-amino-4H-l- oxa-3 ,4-diaza-pentalen-5-yl)-ethyl-amino]-ethanol, 6-methyl-4H- 1 -oxa-3 ,4-diaza- pentalene-2,5-diamine, 2-(2,5-diamino-4H-l-oxa-3,4-diaza-pentalen-6-yl)-ethanol, 6- methoxy-4H-l -oxa-3 ,4-diaza-pentalene-2,5-diamine, 5-amino-4H-l-oxa-3,4-diaza- pentalen-2-ol, and 2-amino-4H-l-oxa-3,4-diaza-pentalen-5-ol. Especially preferred developers are selected from the group consisting of 4H-1- oxa-3,4-diaza-pentalene-2,5-diamine, 2-(5-amino-4H-l -oxa-3, 4-diaza-pentalen-2- ylamino)-ethanol, 2-[(5-amino-4H-l-oxa-3,4-diaza-pentalen-2-yl)-(2-hydroxy-ethyl)- amino]-ethanol, 2-pyrrolidin- 1 -yl-4H- 1 -oxa-3 ,4-diaza-pentalen-5 -ylamine, 5 -amino-4H- 1 -oxa-3, 4-diaza-pentalen-2-ol, and 2-amino-4H-l-oxa-3,4-diaza-pentalen-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of 4H-pyrrolo[2,3- d]oxazol-2-ol, 4H-pyrrolo[2,3-d]oxazol-5-ol, 4H-pyrrolo[2,3-d]oxazol-5-ylamine, 4H- pyrrolo[2,3-d]oxazol-2 -ylamine, 4-methyl-4H-pyrrolo[2,3-d]oxazol-2-ol, 4-methyl-4H- pyrrolo[2,3-d]oxazol-5-ol, 4-methyl-4H-pyrrolo[2,3-d]oxazol-2 -ylamine, 4-methyl-4H- pyrrolo[2,3-d]oxazol-5-ylamine, 6-chloro-4H-pyrrolo[2,3-d]oxazol-5-ol, 6-chloro-4- methyl-4H-pyrrolo[2,3-d]oxazol-5-ol, 5,6-dihydro-4H- 1 ,7-dioxa-3b-aza- cyclopenta[a]inden-2-ylamine, 6-methoxy-4H-pyrrolo[2,3-d]oxazol-5-ylamine, 4H- pyrrolo[2,3-d]oxazole-2,5-diol, 5-amino-4-methyl-4H-pyrrolo[2,3-d]oxazol-2-ol, 2- amino-4-methyl-4H-pyrrolo[2,3-d]oxazol-5-ol, 5-amino-4H-pyrrolo[2,3-d]oxazol-2-ol, 2- amino-4H-pyrrolo[2,3-d]oxazol-5-ol, 4H-pyrrolo[2,3-d]oxazole, 2,5-dimethyl-4H- pyrrolo[2,3-d]oxazole, 6-methyl-4H-pyrrolo[2,3-d]oxazole, 2-methyl-4H-pyrrolo[2,3- djoxazole, 5-methyl-4H-pyrrolo[2,3-d]oxazole, 4-methyl-4H-pyrrolo[2,3-d]oxazole, 2,4,5-trimethyl-4H-pyrrolo[2,3-d]oxazole, 2,4-dimethyl-4H-pyrrolo[2,3-d]oxazole, 4,5- dimethyl-4H-pyrrolo[2,3-d]oxazole, 4,6-dimethyl-4H-pyrrolo[2,3-d]oxazole, 2-methoxy- 4H-pyrrolo[2,3-d]oxazole, 5-methoxy-4H-pyrrolo[2,3-d]oxazole, 2-ethoxy-4H- pyrrolo[2,3-d]oxazole, 5-ethoxy-4H-pyrrolo[2,3-d]oxazole, 5-methoxy-4-methyl-4H- pyrrolo[2,3-d]oxazole, 2-methoxy-4-methyl-4H-pyrrolo[2,3-d]oxazole, (4H-pyrrolo[2,3- d]oxazol-2-yl)methanol, (4H-pyrrolo[2,3-d]oxazol-5-yl)methanol, 2-(4H-pyrrolo[2,3- d]oxazol-5-yl)ethanol, 2-(4H-pyrrolo[2,3-d]oxazol-2-yl)ethanol, (4-methyl-4H- pyrrolo[2,3-d]oxazol-2-yl)methanol, and (4-methyl-4H-pyrrolo[2,3-d]oxazol-5- yl)methanol. Especially preferred couplers are selected from the group consisting of 4H- pyrrolo[2,3-d]oxazol-2-ol, 4H-pyrrolo[2,3-d]oxazol-5-ol, 4H-pyrrolo[2,3-d]oxazol-5- ylamine, 4H-pyrrolo[2,3-d]oxazole-2,5-diol, 4H-pyrrolo[2,3-d]oxazole, 2,5-dimethyl-4H- pyrrolo[2,3-d]oxazole, 4H-pyrrolo[2,3-d]oxazole-3,6-diol, 2-methyl-4H-pyrrolo[2,3- d]oxazole, 5-methyl-4H-pyrrolo[2,3-d]oxazole, (4H-pyrrolo[2,3-d]oxazol-2-yl)methanol, and (4H-pyrrolo[2,3-d]oxazol-5-yl)methanol. 3. Thienooxazoles a. Preferred Developers Preferred developers are selected from the group consisting of thieno[2,3- d]oxazole-2,5-diamine, N2-methyl-thieno[2,3-d]oxazole-2,5-diamine, N2-ethyl- thieno[2,3-d]oxazole-2,5-diamine, 2-(5-amino-thieno[2,3-d]oxazol-2-ylamino)-ethanol, 2-[(5-amino-thieno[2,3-d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1- yl-thieno[2,3-d]oxazol-5-ylamine, N5-methyl-thieno[2,3-d]oxazole-2,5-diamine, N5- ethyl-thieno[2,3-d]oxazole-2,5-diamine, 2-(2-amino-thieno[2,3-d]oxazol-5-ylamino)- ethanol, 2-[(2-amino-thieno[2,3-d]oxazol-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5- pyrrolidin-l-yl-thieno[2,3-d]oxazol-2-ylamine, 2-[(2-amino-thieno[2,3-d]oxazol-5-yl)- ethyl-amino]-ethanol, 6-methyl-thieno[2,3-d]oxazole-2,5-diamine, 2-(2,5-diamino- thieno[2,3-d]oxazol-6-yl)-ethanol, 6-methoxy-thieno[2,3-d]oxazole-2,5-diamine, 5- amino-thieno[2,3-d]oxazol-2-ol, and 2-Amino-thieno[2,3-d]oxazoI-5-ol. Especially preferred developers of the present invention are selected from the group consisting of thieno[2,3-d]oxazole-2,5-diamine, 2-(5-amino-thieno[2,3-d]oxazol-2- ylamino)-ethanol, 2-[(5-amino-thieno[2,3-d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin-l-yl-thieno[2,3-d]oxazol-5-ylamine, 5-amino-thieno[2,3-d]oxazol-2- ol, and 2-Amino-thieno[2,3-d]oxazol-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of thieno[2,3-d]oxazol- 2-ol, thieno[2,3-d]oxazol-5-ol, thieno[2,3-d]oxazol-5-ylamine, thieno[2,3-d]oxazol-2- ylamine, 6-chloro-thieno[2,3-d]oxazol-5-ol, 6-amino-thieno[2,3-d]oxazol-5-ol, 6-amino- thieno[2,3-d]oxazol-2-ol, 3-methoxy-thieno[2,3-d]oxazol-2-ylamine, 6-methoxy- thieno[2,3-d]oxazol-5-ylamine, thieno[2,3-d]oxazol-2,5-diol, 5-amino-thieno[2,3- d]oxazol-2-ol, 2-amino-thieno[2,3-d]oxazol-5-ol, thieno[2,3-d]oxazole, 2,5-dimethyl- thieno[2,3-d]oxazole, 6-methyl-thieno[2,3-d]oxazole, 2-methyl-thieno[2,3-d]oxazole, 5- methyl-thieno[2,3-d]oxazole, 2-methoxy-thieno[2,3-d]oxazole, 5-methoxy-thieno[2,3- djoxazole, 2-ethoxy-thieno[2,3-d]oxazole, 5-ethoxy-thieno[2,3-d]oxazole, (thieno[2,3- d]oxazol-2-yl)methanol, (thieno[2,3-d]oxazol-5-yl)methanol, 2-(thieno[2,3-d]oxazol-5- yl)ethanol, and 2-(thieno[2,3-d]oxazol-2-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of thieno[2,3-d]oxazol-2-ol, thieno[2,3-d]oxazol-5-ol, thieno[2,3-d]oxazol-5- ylamine, thieno[2,3-d]oxazol-2,5-diol, thieno[2,3-d]oxazole, 2,5-dimethyl-thieno[2,3- d]oxazole, 2-methyl-thieno[2,3-d]oxazole, 5-methyl-thieno[2,3-d]oxazole, (thieno[2,3- d]oxazol-2-yl)methanol, and (thieno[2,3-d]oxazol-5-yl)methanol. 4. Furoimidazoles a. Preferred Developers Prefen-ed developers are selected from the group consisting of lH-furo[2,3- d]imidazole-2,5-diamine, N2-methyl-lH-furo[2,3-d]imidazole-2,5-diamine, N2-ethyl-lH- fiιro[2,3-d]imidazole-2,5-diamine, 2-(5-amino-lH-furo[2,3-d]imidazol-2-ylamino)- ethanol, 2-[(5-amino-lH-furo[2,3-d]imidazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2- pyrrolidin-l-yl-lH-furo[2,3-d]imidazol-5-ylamine, N5-methyl-lH-fuiO[2,3-d]imidazole- 2,5-diamine, N5-ethyl-lH-furo[2,3-d]imidazole-2,5-diamine, 2-(2-amino-lH-furo[2,3- d]imidazol-5-ylamino)-ethanol, 2-[(2-amino-lH-furo[2,3-d]imidazol-5-yl)-(2-hydroxy- ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-lH-furo[2,3-d]imidazol-2-ylamine, 2-[(2-amino- lH-furo[2,3-d]imidazol-5-yl)-ethyl-amino]-ethanol, 6-methyl-lH-furo[2,3-d]imidazole- 2,5-diamine, 2-(2,5-diamino-lH-furo[2,3-d]imidazol-6-yl)-ethanol, 6-methoxy-lH- furo[2,3-d]imidazole-2,5-diamine, 5-amino-lH-furo[2,3-d]imidazol-2-ol, and 2-amino- lH-furo[2,3-d]imidazol-5-ol. Especially preferred developers of the present invention are selected from the group consisting of lH-furo[2,3-d]imidazole-2,5-diamine, 2-(5-amino-lH-furo[2,3- d]imidazol-2-ylamino)-ethanol, 2-[(5-amino-lH-furo[2,3-d]imidazol-2-yl)-(2-hydroxy- ethyl)-amino] -ethanol, 2-pyrrolidin-l-yl-lH-furo[2,3-d]imidazol-5-ylamine, 5-amino-lH- furo[2,3-d]imidazol-2-ol, and 2-amino-lH-furo[2,3-d]imidazol-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of lH-furo[3,2- d]imidazol-2-ol, lH-furo[3,2-d]imidazol-5-ol, lH-furo[3,2-d]imidazol-5-ylamine, 1H- furo[3,2-d]imidazol-2-ylamine, l-methyl-lH-furo[3,2-d]imidazol-2-ol, 1-methyl-lH- furo[3,2-d]imidazol-5-ol, 1 -methyl- lH-furo[3,2-d]imidazol-2-ylamine, 1-methyl-lH- furo[3,2-d]imidazol-5-ylamine, 6-chloro-lH-furo[3,2-d]imidazol-5-ol, 6-chloro-l-methyl- lH-furo[3,2-d]imidazol-5-ol, 6-methoxy-lH-furo[3,2-d]imidazol-5-ylamine, lH-furo[3,2- d]imidazole-2,5-diol, 5-amino- 1 -methyl- lH-furo[3 ,2-d]imidazol-2-ol, 2-amino- 1 -methyl- lH-furo[3,2-d]imidazol-5-ol, 5-amino-lH-furo[3,2-d]imidazol-2-ol, 2-amino-lH- furo[3,2-d]imidazol-5-ol, lH-furo[3,2-d]imidazole, 2,5-dimethyl-lH-furo[3,2- djimidazole, 6-methyl-lH-furo[3,2-d]imidazole, 2-methyl-lH-furo[3,2-d]imidazole, 5- methyl-lH-furo[3,2-d]imidazole, l-methyl-lH-furo[3,2-d]imidazole, 1,2,5-trimethyl-lH- furo[3,2-d]imidazole, l,2-dimethyl-lH-furo[3,2-d]imidazole, l,5-dimethyl-lH-furo[3,2- d]imidazole, l,6-dimethyl-lH-furo[3,2-d]imidazole, 2-methoxy-lH-furo[3,2-d]imidazole, 5-methoxy-lH-furo[3,2-d]imidazole, 2-ethoxy-lH-furo[3,2-d]imidazole, 5-ethoxy-lH- furo[3,2-d]imidazole, 5-methoxy-l -methyl-lH-furo[3,2-d]imidazole, 2-methoxy- 1 - methyl-lH-furo[3,2-d]imidazole, (lH-furo[3,2-d]imidazol-2-yl)methanol, (lH-furo[3,2- d]imidazol-5-yl)methanol, 2-(lH-furo[3,2-d]imidazol-5-yl)ethanol, 2-(lH-furo[3,2- d]imidazol-2-yl)ethanol, (l-methyl-lH-furo[3,2-d]imidazol-2-yl)methanol, and (1- methyl- 1 H-furo [3 ,2-d]imidazol-5-yl)methanol. Especially preferred couplers are selected from the group consisting of 1H- ftxro[3,2-d]imidazol-2-ol, lH-furo[3,2-d]imidazol-5-ol, lH-furo[3,2-d]imidazol-5- ylamine, lH-fiιro[3,2-d]imidazole-2,5-diol, lH-furo[3,2-d]imidazole, 2,5-dimethyl-lH- furo[3,2-d]imidazole, lH-furo[3,2-d]imidazole-3,6-diol, 2-methyl-lH-furo[3,2- d]imidazole, 5-methyl-lH-furo[3,2-d]imidazole, (lH-furo[3,2-d]imidazol-2-yl)methanol, and ( 1 H-furo [3 ,2-d] imidazol-5 -yl)methanol . 5. Pyrroloimidazoles a. Preferred Developers Preferred developers are selected from the group consisting of 1,4-dihydro- pyrrolo[2,3-d]imidazole-2,5-diamine, N2-methyl-l,4-dihydro-pyrrolo[2,3-d]imidazole- 2,5-diamine, N2-ethyl-l,4-dihydro-pyrrolo[2,3-d]imidazole-2,5-diamine, 2-(5-amino-l,4- dihydro-pyrrolo[2,3-d]imidazol-2-ylamino)-ethanol, 2-[(5-amino- 1 ,4-dihydro- pyrrolo[2,3 -d]imidazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl- 1 ,4- dihydro-pyrrolo[2,3-d]imidazol-5-ylamine, N5-methyl- 1 ,4-dihydro-pyrrolo[2,3- d]imidazole-2,5-diamine, N5-ethyl- 1 ,4-dihydro-pyrrolo[2,3-d]imidazole-2,5-diamine, 2- (2-amino-l ,4-dihydro-pyrrolo[2,3-d]imidazol-5-ylamino)-ethanol, 2-[(2-amino-l,4- dihydro-pyrrolo[2,3-d]imidazol-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin- 1 - yl-l,4-dihydro-pyrrolo[2,3-d]imidazol-2 -ylamine, 2-[(2-amino-l,4-dihydro-pyrrolo[2,3- d]imidazol-5-yl)-ethyl-amino]-ethanol, 6-methyl-l,4-dihydro-pyrrolo[2,3-d]imidazole- 2,5-diamine, 2-(2,5-diamino-l,4-dihydro-pyrrolo[2,3-d]imidazol-6-yl)-ethanol, 6- methoxy-l ,4-dihydro-pyrrolo[2,3-d]imidazole-2,5-diamine, 5-amino-l,4-dihydro- pyrrolo[2,3-d]imidazol-2-ol, and 2-amino-l,4-dihydro-pyrrolo[2,3-d]imidazol-5-ol. Especially preferred developers of the present invention are selected from the group consisting of l,4-dihydro-pyrrolo[2,3-d]imidazole-2,5-diamine, 2-(5 -amino- 1,4- dihydro-pyrrolo[2,3-d]imidazol-2-ylamino)-ethanol, 2-[(5-amino- 1 ,4-dihydro- pyrrolo[2,3 -d]imidazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 -yl- 1 ,4- dihydro-pyrrolo[2,3-d]imidazol-5-ylamine, 5-amino-l,4-dihydro-pyrrolo[2,3-d]imidazol- 2-ol, and 2-amino-l,4-dihydro-pyrrolo[2,3-d]imidazol-5-ol. b. Preferred Couplers Preferced couplers are selected from the group consisting of 1,4-dihydro- pyrrolo[3,2-d]imidazol-2-ol, l,4-dihydro-pyrrolo[3,2-d]imidazol-2-ylamine, 1,4-dihydro- pyrrolo[3,2-d]imidazole-2,5-diol, 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3,2-d]imidazol-2-ol, 5-amino- 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3,2-d]imidazol-2-ol, 1 ,4-dimethyl- 1 ,4- dihydro-pyτrolo[3 ,2-d]imidazol-2-ylamine, 1 ,4-dimethyl- 1 ,4-dihydro-pyrrolo[3 ,2- d]imidazole-2,5-diamine, l,4-dihydro-pyrrolo[3,2-d]imidazole, 2,5-dimethyl-l,4-dihydro- ρyrrolo[3,2-d]imidazole, 2-methyl- 1 ,4-dihydro-pyrrolo[3 ,2-d]imidazole, 1 ,4-dimethyl- l,4-dihydro-pyrrolo[3,2-d]imidazole, l,2,4,5-tetramethyl-l,4-dihydro-pyrrolo[3,2- d]imidazole, 1 ,2,4-trimethyl- 1 ,4-dihydro-pyrrolo[3,2-d]imidazole, 1 ,3 ,4-trimethyl- 1 ,4- dihydro-pyrrolo[3 ,2-d]imidazole, 1 ,4-dihydro-2-methoxy-pyrrolo[3 ,2-d]imidazole, 1 ,4- dihydro-2-ethoxy-pyrrolo[3,2-d]imidazole, 1 ,4-dimethyl- 1 ,4-dihydro-2-methoxy- pyrrolo[3,2-d]imidazole, 1 ,4-dimethyl- 1 ,4-dihydro-2-ethoxy-pyrrolo[3,2-d]imidazole, (l,4-dihydropyrrolo[3,2-d]imidazol-5-yl)methanol, 2-(l,4-dihydropyrrolo[3,2-d]imidazol- 5-yl)ethanol, (l,4-dihydro-l,4-dimethylpyrrolo[3,2-d]imidazol-5-yl)methanol, and 2-(l,4- dihydro- 1 ,4-dimethylpyrrolo[3,2-d]imidazol-5-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of l,4-dihydro-pyrrolo[3,2-d]imidazol-2-ol, l,4-dihydro-pyrrolo[3,2- d]imidazol-2 -ylamine, 1 ,4-dihydro-pyrrolo[3,2-d]imidazole-2,5-diol, 1 ,4-dihydro- pyrrolo[3,2-d]imidazole, 2,5-dimethyl-l,4-dihydro-pyrrolo[3,2-d]imidazole, 2-methyl- 1 ,4-dihydro-pyrrolo[3,2-d]imidazole, and (1 ,4-dihydropyrrolo[3,2-d]imidazol-5- yl)methanol. 6. Thienoimidazoles a. Preferred Developers Preferred developers are selected from the group consisting of lH-thieno[2,3- d]imidazole-2,5-diamine, N2-methyl-lH-thieno[2,3-d]imidazole-2,5-diamine, N2-ethyl- lH-thieno[2,3-d]imidazole-2,5-diamine, 2-(5-amino-lH-thieno[2,3-d]imidazol-2- ylamino)-ethanol, 2~[(5-amino-lH-thieno[2,3-d]imidazol-2-yl)-(2-hydroxy-ethyl)- amino] -ethanol, 2-pyrrolidin-l-yl-lH-thieno[2,3-d]imidazol-5-ylamine, N5-methyl-lH- thieno[2,3-d]imidazole-2,5-diamine, N5-ethyl-lH-thieno[2,3-d]imidazole-2,5-diamine, 2- (2-anτino-lH-thieno[2,3-d]imidazol-5-ylamino)-ethanol, 2-[(2-amino-lH-thieno[2,3- d]imidazol-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-lH-thieno[2,3- d]imidazol-2 -ylamine, 2-[(2-amino-lH-thieno[2,3-d]imidazol-5-yl)-ethyl-amino]-ethanol, 6-methyl-lH-thieno[2,3-d]imidazole-2,5-diamine, 2-(2,5-diamino-lH-thieno[2,3- d]imidazol-6-yl)-ethanol, 6-methoxy- lH-thieno[2,3-d]imidazole-2,5-diamine, 5-amino- lH-thieno[2,3-d]imidazol-2-ol, and 2-amino- lH-thieno[2,3-d]imidazol-5-ol. Especially preferred developers of the present invention are selected from the group consisting of lH-thieno[2,3-d]imidazole-2,5-diamine, 2-(5-amino-lH-thieno[2,3- d]imidazol-2-ylamino)-ethanol, 2-[(5-amino-lH-thieno[2,3-d]imidazol-2-yl)-(2 -hydroxy- ethyl)-amino]-ethanol, 2-pyrrolidin-l-yl-lH-thieno[2,3-d]imidazol-5-ylamine, 5-amino- lH-thieno[2,3-d]imidazol-2-ol, and 2-amino-lH-thieno[2,3-d]imidazol-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of 1 H-thieno [3 ,2- d]imidazol-2-ol, lH-thieno[3,2-d]imidazol-5-ol, lH-thieno[3,2-d]imidazol-5-ylamine, lH-thieno[3,2-d]imidazol-2 -ylamine, 1 -methyl- lH-thieno[3,2-d]imidazol-2-ol, 1 -methyl- lH-thieno[3,2-d]imidazol-5-ol, 1 -methyl- lH-thieno [3, 2-d]imidazol-2-ylamine, 1-methyl- lH-thieno[3,2-d]imidazol-5-ylamine, 6-chloro-lH-thieno[3,2-d]imidazol-5-ol, 6-chloro- 1 -methyl- 1 H-thieno [3 ,2-d] imidazol-5 -ol, 6-methoxy- 1 H-thieno [3 ,2-d] imidazol-5 - ylamine, lH-thieno[3,2-d]imidazole-2,5-diol, 5-amino-l -methyl- lH-thieno[3, 2- d]imidazol-2-ol, 2-amino- 1 -methyl- 1 H-thieno[3 ,2-d]imidazol-5-ol, 5-amino- 1H- thieno[3,2-d]imidazol-2-ol, 2-amino-lH-thieno[3,2-d]imidazol-5-ol, lH-thieno[3,2- d]imidazole, 2,5-dimethyl-lH-thieno[3,2-d]imidazole, 6-methyl-lH-thieno[3,2- djimidazole, 2-methyl-lH-thieno[3,2-d]imidazole, 5-methyl-lH-thieno[3,2-d]imidazole, l-methyl-lH-thieno[3,2-d]imidazole, l,2,5-trimethyl-lH-thieno[3,2-d]imidazole, 1,2- dimethyl- 1 H-thieno [3 ,2-d] imidazole, 1 ,5-dimethyl- lH-thieno[3,2-d]imidazole, 1 ,6- dimethyl-lH-thieno[3,2-d]imidazole, 2-methoxy-lH-thieno[3,2-d]imidazole, 5-methoxy- 1 H-thieno [3 ,2-d]imidazole, 2-ethoxy- 1 H-thieno[3 ,2-d]imidazole, 5 -ethoxy- 1 H- thieno[3,2-d]imidazole, 5-methoxy-l-methyl-lH-thieno[3,2-d]imidazole, 2-methoxy-l- methyl-lH-thieno[3,2-d]imidazole, (lH-thieno[3,2-d]imidazol-2-yl)methanol, (1H- thieno[3,2-d]imidazol-5-yl)methanol, 2-(lH-thieno[3,2-d]imidazol-5-yl)ethanol, 2-(lH- thieno[3,2-d]imidazol-2-yl)ethanol, (l-methyl-lH-thieno[3,2-d]imidazol-2-yl)methanol, and (l-methyl-lH-thieno[3,2-d]imidazol-5-yl)methanol. Especially preferred couplers are selected from the group consisting of 1H- thieno[3,2-d]imidazol-2-ol, lH-thieno[3,2-d]imidazol-5-ol, lH-thieno[3,2-d]imidazol-5- ylamine, lH-thieno[3,2-d]imidazole-2,5-diol, lH-thieno[3,2-d]imidazole, 2,5-dimethyl- lH-thieno[3,2-d]imidazole, lH-thieno[3,2-d]imidazole-3,6-diol, 2-methyl- lH-thieno[3,2- d]imidazole, 5-methyl-lH-thieno[3,2-d]imidazole, (lH-thieno[3,2-d]imidazol-2- yl)methanol, and (lH-thieno[3,2-d]imidazol-5-yl)methanol. 7. Furothiazoles a. Preferred Developers Preferred developers are selected from the group consisting of furo[2,3-d]thiazole- 2,5-diamine, N2-methyl-furo[2,3-d]thiazole-255-diamine, N2-ethyl-furo[2,3-d]thiazole- 2,5-diamine, 2-(5-amino-furo[2,3-d]thiazol-2-ylamino)-ethanol, 2-[(5-amino-furo[2,3- d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin-l-yl-furo[2,3-d]thiazol-5- ylamine, N5-methyl-furo[2,3-d]thiazole-2,5-diamine, N5-ethyl-furo[2,3-d]thiazole-2,5- diamine, 2-(2-amino-furo[2,3-d]thiazol-5-ylamino)-ethanol, 2-[(2-amino-furo[2,3- d]thiazol-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-furo[2,3-d]thiazol-2- ylamine, 2-[(2-amino-furo[2,3-d]thiazol-5-yl)-ethyl-amino]-ethanol, 6-methyl-furo[2,3- d]thiazole-2,5-diamine, 2-(2,5-diamino-furo[2,3-d]thiazol-6-yl)-ethanol, 6-methoxy- fiιro[2,3-d]thiazole-2,5-diamine, 5-amino-furo[2,3-d]thiazol-2-ol, and 2-amino-furo[2,3- d]thiazol-5-ol. Especially preferred developers of the present invention are selected from the group consisting of furo[2,3-d]thiazole-2,5-diamine, 2-(5-amino-furo[2,3-d]thiazol-2- ylamino)-ethanoI, 2-[(5-amino-furo[2,3-d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin- 1 -yl-furo[2,3-d]thiazol-5-ylamine, 5-amino-furo[2,3-d]thiazol-2-ol, and 2-amino-furo[2,3-d]thiazol-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of furo[2,3-d]thiazol-2- ol, furo[2,3-d]thiazol-5-ol, furo[2,3-d]thiazol-5-ylamine, furo[2,3-d]thiazol-2-ylamine, 6- chloro-furo[2,3-d]thiazol-5-ol, 6-amino-furo[2,3-d]thiazol-5-ol, 6-amino-furo[2,3- d]thiazol-2-ol, 3-methoxy-furo[2,3-d]thiazol-2 -ylamine, 6-methoxy-furo[2,3-d]thiazol-5- ylamine, furo[2,3-d]thiazol-2,5-diol, 5-amino-furo[2,3-d]thiazol-2-ol, 2-amino-furo[2,3- d]thiazol-5-ol, furo[2,3-d]thiazole, 2,5-dimethyl-furo[2,3-d]thiazole, 6-methyl-furo[2,3- djthiazole, 2-methyl-fixro[2,3-d]thiazole, 5-methyl-furo[2,3-d]thiazole, 2-methoxy- furo[2,3-d]thiazole, 5-methoxy-furo[2,3-d]thiazole, 2-ethoxy-furo[2,3-d]thiazole, 5- ethoxy-fuiO[2,3-d]thiazole, (fixro[2,3-d]thiazol-2-yl)methanol, (furo[2,3-d]thiazol-5- yl)methanol, 2-(furo[2,3-d]thiazol-5-yl)ethanol, and 2-(furo[2,3-d]thiazol-2-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of furo[2,3-d]thiazol-2-ol, furo[2,3-d]thiazol-5-ol, fiιro[2,3-d]thiazol-5- ylamine, furo[2,3-d]thiazol-2,5-diol, furo[2,3-d]thiazole, 2,5-dimethyl-furo[2,3- d]thiazole, 2-methyl-furo[2,3-d]thiazole, 5-methyl-furo[2,3-d]thiazole, (furo[2,3- d]thiazol-2-yl)methanol, and (furo[2,3-d]thiazol-5-yl)methanol. 8. Pyrrolothiazoles a. Preferred Developers Preferred developers are selected from the group consisting of 4H-Pyrrolo[2,3- d]thiazole-2,5-diamine, N2-methyl-4H-pyrrolo[2,3-d]thiazole-2,5-diamine, N2-ethyl-4H- pynOlo[2,3-d]thiazole-2,5-diamine, 2-(5-amino-4H-pyrrolo[2,3-d]thiazol-2-ylamino)- ethanol, 2-[(5-amino-4H-pyrrolo[2,3-d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin-l-yl-4H-pyrrolo[2,3-d]thiazol-5-ylamine, N5-ethyl-4H-pyrrolo[2,3- d]thiazole-2,5-diamine, N5-ethyl-4H-pyrrolo[2,3-d]thiazole-2,5-diamine, 2-(2-amino-4H- pyrrolo[2,3-d]thiazol-5-ylamino)-ethanol, 2-[(2-amino-4H-pyrrolo[2,3-d]thiazol-5-yl)-(2- hydroxy-ethyl)-amino] -ethanol, 5-pyrrolidin- 1 -yl-4H-pyrrolo[2,3-d]thiazol-2-ylamine, 2- [(2-amino-4H-pyrrolo[2,3-d]thiazol-5-yl)-ethyl-amino]-ethanol, 6-methyl-4H- pyrrolo[2,3-d]thiazole-2,5-diamine, 2-(2,5-diamino-4H-pyrrolo[2,3-d]thiazol-6-yl)- ethanol, 6-methoxy-4H-pyrrolo[2,3-d]thiazole-2,5-diamine, 5-amino-4H-pyrrolo[2,3- d]thiazoI-2-ol, and 2-amino-4H-pyrrolo[2,3-d]thiazol-5-ol. Especially preferred developers of the present invention are selected from the group consisting of 4H-Pyrrolo[2,3-d]thiazole-2,5-diamine, N2-methyl-4H-pyrrolo[2,3- d]thiazole-2,5-diamine, N2-ethyl-4H-pyrrolo[2,3-d]thiazole-2,5-diamine, 2-(5-amino-4H- pyrrolo[2,3-d]thiazol-2-ylamino)-ethanol, 2-[(5-amino-4H-pyrrolo[2,3-d]thiazol-2-yl)-(2- hydroxy-ethyl)-amino]-ethanol, 2-pyπOlidin-l-yl-4H-pyrrolo[2,3-d]thiazol-5-ylamine, 5- amino-4H-pyrrolo[2,3-d]thiazol-2-ol, and 2-amino-4H-pyrrolo[2,3-d]thiazol-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of 4H-pyrrolo[2,3- d]thiazol-2-ol, 4H-pyrrolo[2,3-d]thiazol-5-ol, 4H-pyrrolo[2,3-d]thiazol-5-ylamine, 4H- pyrrolo[2,3-d]thiazol-2-ylamine, 4-methyl-4H-pyrrolo[2,3-d]thiazol-2-ol, 4-methyl-4H- pyrrolo[2,3-d]thiazol-5-ol, 4-methyl-4H-pyrrolo[2,3-d]thiazol-2-ylamine, 4-methyl-4H- pyrrolo[2,3-d]thiazol-5-ylamine, 6-chloro-4H-pyrrolo[2,3-d]thiazol-5-ol, 6-chloro-4- methyl-4H-pyrrolo[2,3-d]thiazol-5-ol, 5,6-dihydro-4H- 1 ,7-dithia-3b-aza- cyclopenta[a]inden-2-ylamine, 6-methoxy-4H-pyrrolo[2,3-d]thiazol-5-ylamine, 4H- pyrrolo[2,3-d]thiazole-2,5-diol, 5-amino-4-methyl-4H-pyrrolo[2,3-d]thiazol-2-ol, 2- amino-4-methyl-4H-pyrrolo[2,3-d]thiazol-5-ol, 5-amino-4H-pyrrolo[2,3-d]thiazol-2-ol, 2- amino-4H-pyrrolo[2,3-d]thiazol-5-ol, 4H-pyrrolo[2,3-d]thiazole, 2,5-dimethyl-4H- pyrrolo[2,3-d]thiazole, 6-methyl-4H-pyrrolo[2,3-d]thiazole, 2-methyl-4H-pyrrolo[2,3- djthiazole, 5-methyl-4H-pyrrolo[2 ,3-d]thiazole, 4-methyl-4H-pyrrolo[2,3-d]thiazole, 2,4,5-trimethyl-4H-pyrrolo[2,3-d]thiazole, 2,4-dimethyl-4H-pyrrolo[2,3-d]thiazole, 4,5- dimethyl-4H-pyrrolo[2,3-d]thiazole, 4,6-dimethyl-4H-pyrrolo[2,3-d]thiazole, 2-methoxy- 4H-pyrrolo[2,3-d]thiazole, 5-methoxy-4H-pyrrolo [2,3 -djthiazole, 2-ethoxy-4H- pyrrolo[2,3-d]thiazole, 5-ethoxy-4H-pyrrolo[2,3-d]thiazole, 5-methoxy-4-methyl-4H- pyrrolo[2,3-d]thiazole, 2-methoxy-4-methyl-4H-pyrrolo[2,3-d]thiazole, (4H-pyrrolo[2,3- d]thiazol-2-yl)methanol, (4H-pyrrolo[2,3-d]thiazol-5-yl)methanol, 2-(4H-pyrrolo[2,3- d]thiazol-5-yl)ethanol, 2-(4H-pyrrolo[2,3-d]thiazol-2-yl)ethanol, (4-methyl-4H- pyrrolo[2,3-d]thiazol-2-yl)methanol, and (4-methyl-4H-pyrrolo[2,3-d]thiazol-5- yl)methanol. Especially preferred couplers are selected from the group consisting of 4H- pyrτolo[2,3-djthiazol-2-ol, 4H-pyrrolo[2,3-d]thiazol-5-ol, 4H-pyrrolo[2,3-d]thiazol-5- ylamine, 4H-pyrrolo[2,3-d]thiazole-2,5-diol, 4H-pyrrolo[2,3-d]thiazole, 2,5-dimethyl-4H- pyrrolo[2,3-d]thiazole, 4H-pyrrolo [2,3-d]thiazole-3,6-diol, 2-methyl-4H-pyrroIo[2,3- djthiazole, 5-methyl-4H-pynolo[2,3-d]thiazole, (4H-pyrrolo[2,3-d]thiazol-2-yl)methanol, and (4H-pyrrolo[2,3-d]thiazol-5-yl)methanol. 9. Thienothiazoles a. Preferred Developers Preferred developers are selected from the group consisting of thieno[2,3- d]thiazole-2,5-diamine, N2-methyl-thieno[2,3-d]thiazole-2,5-diamine, N2-ethyl- thieno[2,3-d]thiazole-2,5-diamine, 2-(5-amino-thieno[2,3-d]thiazol-2-ylamino)-ethanol, 2-[(5-amino-thieno[2,3-d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- 1 - yl-thieno[2,3-d]thiazol-5-ylamine, KT5-methyl-thieno[2,3-d]thiazole-2,5-diamine, N5- ethyl-thieno[2,3-d]thiazole-2,5-diamine, 2-(2-amino-thieno[2,3-d]thiazol-5-ylamino)- ethanol, 2-[(2-amino-thieno[2,3-d]thiazol-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5- pyrrolidin-l-yl-thieno[2,3-d]thiazol-2-ylamine, 2-[(2-amino-thieno[2,3-d]thiazol-5-yl)- ethyl-amino]-ethanol, 6-methyl-thieno[2,3-d]thiazole-2,5-diamine, 2-(2,5-diamino- thieno[2,3-d]thiazol-6-yl)-ethanol, 6-methoxy-thieno[2,3-d]thiazole-2,5-diamine, 5- amino-thieno[2,3-d]thiazol-2-ol, 2-amino-thieno[2,3-d]thiazol-5-ol, and 2-amino- thieno[2,3-d]thiazole-6-carboxylic acid methyl ester. Especially preferred developers of the present invention are selected from the group consisting of thieno[2,3-d]thiazole-2,5-diamine, 2-(5-amino-thieno[2,3-d]thiazol-2- ylamino)-ethanol, 2-[(5-amino-thieno[2,3-d]thiazol-2-yl)-(2-hydroxy-ethyl)-amino]- ethanol, 2-pyrrolidin-l-yl-thieno[2,3-d]thiazol-5-ylamine, 5-amino-thieno[2,3-d]thiazol- 2-ol, and 2-amino-thieno[2,3-d]thiazol-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of thieno[2,3-d]thiazol- 2-ol, thieno[2,3-d]thiazol-5-ol, thieno[2,3-d]thiazol-5-ylamine, thieno[2,3-d]thiazol-2- ylamine, 6-chloro-thieno[2,3-d]thiazol-5-ol, 6-amino-thieno[2,3-d]thiazol-5-ol, 6-amino- thieno[2,3-d]thiazol-2-ol, 3-methoxy-thieno[2,3-d]thiazol-2-ylamine, 6-methoxy- thieno[2,3-d]thiazol-5-ylamine, thieno[2,3-d]thiazol-2,5-diol, 5-amino-thieno[2,3- d]thiazol-2-ol, 2-amino-thieno[2,3-d]thiazol-5-ol, thieno[2,3-d]thiazole, 2,5-dimethyl- thieno[2,3-d]thiazole, 6-methyl-thieno[2,3-d]thiazole, 2-methyl-thieno[2,3-d]thiazole, 5- methyl-thieno[2,3-d]thiazole, 2-methoxy-thieno[2,3-d]thiazole, 5-methoxy-thieno[2,3- d]thiazole, 2-ethoxy-thieno[2,3-d]thiazole, 5-ethoxy-thieno[2,3-d]thiazole, (thieno[2,3- d]thiazol-2-yl)methanol, (thieno[2,3-d]thiazol-5-yl)methanol, 2-(thieno[2,3-d]thiazol-5- yl)ethanol, and 2-(thieno[2,3-d]thiazol-2-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of thieno[2,3-d]thiazol-2-ol, thieno[2,3-d]thiazol-5-ol, thieno[2,3-d]thiazol-5- ylamine, thieno[2,3-d]thiazol-2,5-diol, thieno[2,3-d]thiazole, 2,5-dimethyl-thieno[2,3- d]thiazole, 2-methyl-thieno[2,3-d]thiazole, 5-methyl-thieno[2,3-d]thiazole, (thieno[2,3- d]thiazol-2-yl)methanol, and (thieno[2,3-d]thiazol-5-yl)methanol. 10. Furooxazoles a. Preferred Developers Preferred developers are selected from the group consisting of furo[2,3-d]oxazole- 2,5-diamine, N2-methyl-furo[2,3-d]oxazole-2,5-diamine, N2-ethyl-furo[2,3-d]oxazole- 2,5-diamine, 2-(5-amino-furo[2,3-d]oxazol-2-ylamino)-ethanol, 2-[(5-amino-furo[2,3- d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin-l-yl-furo[2,3-d]oxazol-5- ylamine, N5-methyl-furo[2,3-d]oxazole-2,5-diamine, N5-ethyl-furo[2,3-d]oxazole-2,5- diamine, 2-(2-amino-mro[2,3-d]oxazol-5-ylamino)-ethanol, 2-[(2-amino-furo[2,3- d]oxazol-5-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 5-pyrrolidin-l-yl-furo[2,3-d]oxazol-2- ylamine, 2-[(2-amino-furo[2,3-d]oxazol-5-yl)-ethyl-amino]-ethanol, 6-methyl-furo[2,3- d]oxazole-2,5-diamine, 2-(2,5-diamino-furo[2,3-d]oxazol-6-yl)-ethanol, 6-methoxy- furo[2,3-d]oxazole-2,5-diamine, 5-amino-furo[2,3-d]oxazol-2-ol, and 2-amino-furo[2,3- d]oxazol-5-ol. Especially preferred developers of the present invention are selected from the group consisting of furo[2,3-d]oxazole-2,5-diamine, 2-(5-amino-furo[2,3-d]oxazol-2- ylamino)-ethanol, 2-[(5-amino-furo[2,3-d]oxazol-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol, 2-pyrrolidin- l-yl-furo[2,3-d]oxazol-5-ylamine, 5-amino-furo[2,3-d]oxazol-2-ol, and 2- amino-furo[2,3-d]oxazol-5-ol. b. Preferred Couplers Preferred couplers are selected from the group consisting of furo[2,3-d]oxazol-2- ol, fiιro[2,3-d]oxazol-5-ol, furo[2,3-d]oxazol-5-ylamine, furo[2,3-d]oxazol-2-ylamine, 6- chloro-furo[2,3-d]oxazol-5-ol, 6-amino-furo[2,3-d]oxazol-5-ol, 6-amino-furo[2,3- d]oxazol-2-ol, 3-methoxy-furo[2,3-d]oxazol-2-ylamine, 6-methoxy-furo[2,3-d]oxazol-5- ylamine, furo[2,3-d]oxazol-2,5-diol, 5-amino-furo[2,3-d]oxazol-2-ol, 2-amino-furo[2,3- d]oxazol-5-ol, furo[2,3-d]oxazole, 2,5-dimethyl-furo[2,3-d]oxazole, 6-methyl-furo[2,3- djoxazole, 2-methyl-furo[2,3-d]oxazole, 5-methyl-furo[2,3-d]oxazole, 2-methoxy- furo[2,3-d]oxazole, 5-methoxy-furo[2,3-d]oxazole, 2-ethoxy-furo[2,3-d]oxazole, 5- ethoxy-furo[2,3-d]oxazole, (furo[2,3-d]oxazol-2-yl)methanol, (furo[2,3-d]oxazol-5- yl)methanol, 2-(furo[2,3-d]oxazol-5-yl)ethanol, and 2-(furo[2,3-d]oxazol-2-yl)ethanol. Especially preferred couplers of the present invention are selected from the group consisting of furo[2,3-d]oxazol-2-ol, furo[2,3-d]oxazol-5-ol, furo[2,3-d]oxazol-5- ylamine, furo[2,3-d]oxazol-2,5-diol, fixro[2,3-d]oxazole, 2,5-dimethyl-furo[2,3-d]oxazole, 2-methyl-furo[2,3-d]oxazole, 5-methyl-furo[2,3-d]oxazole, (furo[2,3-d]oxazol-2- yl)methanol, and (furo[2,3-d]oxazol-5-yl)methanol. D. Synthesis Examples The following are non-limiting synthesis examples of the present invention. Example A: 4H-thieno[3,2-b]pyrrol-2-ylamine, obtaintable from the following synthesis strategy: CHO CO
7 5
8
Condensation of 2-thiophenecarboxaldehyde 1 with ethyl azidoacetate 2 in the presence of sodium ethoxide affords compound 3. Heat xylene to carry out cyclization of 3 to the thienopyrrole ring 4. Nitration of 4 with copper(II) nitrate in acetic anhydride produces compound 5 (J. Heterocyclic Chem., 1984, 21, 215). Hydrolysis of 5 with sodium hydroxide leads to compound 6. Decarboxylation of 6 with copper powder in quinoline gives compound 7. Reduction of 7 with hydrogen and Pd-C gives compound 8. Example B: 5-pyrrolidin-l-yl-thieno[3,2-b]thiophen-2-ylamine, obtaintable from the following synthesis strategy:
Treatment of 3-bromothiophene 1 with lithium diisopropylamide (LDA) in THF followed by DMF leads to 3-bromo-2-thiophenecarboxaldehyde 2. Reaction of 2 with ethyl 2- mercaptoacetate in the presence of potassium carbonate affords compound 3. Hydrolysis of 3 with aqueous lithium hydroxide in THF gives the corresponding acid 4 (J. Chem. Soc, Perkin Trans. I, 1997, 3465). Curtiuns rearrangement of 4 with diphenyl phosphorylazide (DPP A) in t-BuOH (Tetrahedron, 1974, 30, 2151) affords 2- aminothienothiophene 5. Reaction of 5 with NBS produces compound 6. Palladium (()) catalyzed amination of 6 with pyrrolidine with Pd2(dba)3, BINAP and cesium carbonate (Tet. Letters, 2000, 41, 7731) leads to compound 7. Hydrolysis of 7 with 6N HCI affords compound 8.
Example C: l,4-Dihydropyrrolo[3,2-b]pyrrole, obtainable from the following synthesis strategy: Br -Br ^
CI-C
Reaction of methyl chloroformate (CAS 79-22-1) with sodium azide (CAS 26628-22-8) gives compound 1 (J. Amer. Chem. Soc, 1965, 87, 1947). Reaction of compound 1 with compound 2, which may be obtained from the reaction of 1,4-dibromobenzene (CAS 106- 37-6) with chlorotrimethylsilane (CAS 75-77-4) (Chem. Ber., 1980, 113, 3221), leads to compound 3 (Tetrahedron Lett., 1984, 25, 5669). Reaction of compound 3 with 1,4- dichloro-5,6-dicyano-l,4-benzoquinone (DDQ, CAS 84-58-2) affords compound 4 (Tetrahedron Lett., 1984, 25, 5669). Reaction of compound 4 with potassium hydroxide gives l,4-dihydropyrrolo[3,2-b]pyrrole 1-1 (Tetrahedron Lett., 1984, 25, 5669). Example D: Thieno[3,2-b]thien-2 -ylamine, obtainable from the following synthesis strategy:
Reaction of 3-bromothiophene (CAS 872-31-1) with butyllithium (CAS 109-72-8) and sulfur gives compound 2 (Khim. Pharm. Zhurn., 1992, 26, 52). Reaction of compound 2 with bromoacetaldehyde diethyl acetal (CAS 2032-35-1) leads to compound 3 (Proc.
Indian Acad. Sci., A, 1954, 39, 14). Reaction of compound 3 with phosphorus pentaoxide affords compound 4 (Proc. Indian Acad. Sci., A, 1954, 39, 14). Reaction of compound 4 with nitric acid in acetic anhydride gives compound 5 (J. Inst. Petr. Tech., 1935, 21, 135).
Reaction of compound 5 with tin and hydrochloric acid leads to compound 6 (Khim.
Geterocycl. Soedin., 1965, 1, 334). Reaction of compound 6 with, sodium hydroxide affords thieno[3,2-b]thien-2-ylamine X.
Example E: Thieno[3,2-b]thiophene-2-carboxylic acid available from Maybridge pic,
Cornwall, United Kingdom.
Example F: Thieno[2,3-d]thiazole-6-carboxylic acid, 2-amino-, methyl ester available from SPECS and BioSPECS B.N., Netherlands.
Example G: Thieno[3,2-b]thiophene-2-carboxamide available from Maybridge pic,
Cornwall, United Kingdom.
Example H: Thieno[3,2-b]thiophene-2-carboxylic acid, 5-methyl- available from
Interchim, Cedex, France.
Example I: Thieno[3,2-b]thiophene-2,6-dicarbonitrile, 3,5-diammo- available from
TimTec, Inc., Newark, DE.
Example J: Urea, N-hydroxy-N-(l-thieno[3,2-b]thien-2-ylethyl)- available from
Ambinter, Paris, France.
Example K: Urea, N-hydroxy-N-(thieno[3,2-b]thien-2-ylmethyl)- available from
Ambinter, Paris, France.
Example L: 2,5-Bis(methylthio)-thieno[3,2-b]thiophene available from SYNCHEM
OHG Kassel, Germany.
Example M: Thieno[3,2-b]thiophene-2,5-dicarboxylic acid available from ALDRICH
Chemical Company, Inc.
II. Keratin Dyeing Composition Components The inventive compositions for the oxidative dyeing of keratin fibers comprise the hair-dyeing compound described above in the hair-dyeing compounds section and a medium suitable for dyeing. The inventive compositions may further comprise additional components known, conventionally used, or otherwise effective for use in oxidative dye compositions, including but limited to: developer dye compounds; coupler dye compounds; direct dyes; oxidizing agents; thickeners; chelants; pH modifiers and buffering agents; carbonate ion sources and radical scavenger systems; anionic, cationic, nonionic, amphoteric or zwitterionic surfactants, or mixtures thereof; anionic, cationic, nonionic, amphoteric or zwitterionic polymers, or mixtures thereof; fragrances; buffers; dispersing agents; peroxide stabilizing agents; natural ingredients, e.g. proteins and protein derivatives, and plant materials (e.g. aloe, chamomile and henna extracts); silicones (volatile or non-volatile, modified or non-modified), film-fonning agents, ceramides, preserving agents; and opacifiers. Some adjuvants referred to above, but not specifically described below, which are suitable are listed in the International Cosmetics Ingredient Dictionary and Handbook, (8th ed.; The Cosmetics, Toiletry, and Fragrance Association). Particularly, vol. 2, sections 3 (Chemical Classes) and 4 (Functions) are useful in identifying specific adjuvants to achieve a particular puφose or multipuφose. A. Medium Suitable for Dyeing The medium suitable for dyeing may be selected from water, or a mixture of water and at least one organic solvent to dissolve the compounds that would not typically be sufficiently soluble in water. Suitable organic solvents for use herein include, but are not limited to: CI to C4 lower alkanols (e.g., ethanol, propanol, isopropanol), aromatic alcohols (e.g. benzyl alcohol and phenoxy ethanol); polyols and polyol ethers (e.g., carbitols, 2-butoxyethanol, propylene glycol, propylene glycol monomethyl ether, diethylene glycol monoethyl ether, monomethyl ether, hexylene glycol, glycerol, ethoxy glycol), and propylene carbonate. When present, organic solvents are typically present in an amount ranging from 1% to 30%, by weight, of the composition. Preferred solvents are water, ethanol, propanol, isopropanol, glycerol, 1,2-propylene glycol, hexylene glycol, ethoxy diglycol, and mixtures thereof. Additional mediums suitable for dyeing may include oxidizing agents as described below. B. Auxiliary Developers Suitable developers for use in the compositions described herein include, but are not limited to p-phenylenediamine derivatives, e.g. benzene- 1,4-diamine (commonly known as p-phenylenediamine), 2 -methyl-benzene- 1,4-diamine, 2-chloro-benzene-l ,4- diamine, N-phenyl -benzene- 1,4-diamine, N-(2-ethoxyethyl)benzene- 1,4-diamine, 2- (4- amino-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol, (commonly known as N,N-bis(2- hydroxyethyl)-p-phenylenediamine) (2,5-diamino-phenyl)-methanol, l-(2'-
Hydroxyethyl)-2,5-diaminobenzene, 2-(2,5-diamino-phenyl)-ethanol, N-(4- aminophenyl)benzene- 1 ,4-diamine, 2,6-dimethyl-benzene- 1 ,4-diamine, 2-isopropyl- benzene- 1,4-diamine, l-[(4-aminophenyl)amino]-propan-2-ol, 2-propyl -benzene- 1 ,4- diamine, 1 ,3-bis[(4-aminophenyl)(2-hydroxyethyl)amino]propan-2-ol, N^ ^- trimethylbenzene- 1 ,4-diamine, 2-methoxy-benzene- 1 ,4-diamine, 1 -(2,5- diaminophenyl)ethane- 1 ,2-diol, 2,3-dimethyl-benzene- 1 ,4-diamine, N-(4-amino-3- hydroxy-phenyl)-acetamide, 2,6-diethylbenzene- 1,4-diamine, 2,5-dimethylbenzene-l ,4- diamine, 2-thien-2-ylbenzene- 1,4-diamine, 2-thien-3-ylbenzene- 1,4-diamine, 2-pyridin-3- ylbenzene- 1 ,4-diamine, 1 , 1 '-biphenyl-2,5-diamine, 2-(methoxymethyl)benzene- 1 ,4- diamine, 2-(aminomethyl)benzene- 1,4-diamine, 2-(2,5-diaminophenoxy)ethanol, N-[2- (2,5-diaminophenoxy)ethyl]-acetamide, N,N-dimethylbenzene-l ,4-diamine, N,N- diethylbenzene- 1 ,4-diamine, N,N-dipropylbenzene- 1 ,4-diamine, 2- (4- aminophenyl)(ethyl)amino]ethanol, 2-[(4-amino-3-methyl-phenyl)-(2-hydroxy-ethyl)- amino]-ethanol, N-(2-methoxyethyl)-benzene- 1,4-diamine, 3-[(4- aminophenyl)amino]propan- 1 -ol, 3-[(4-aminophenyl)-amino]propane- 1 ,2-diol, N- {4- f(4- aminophenyl)amino]butyl} benzene- 1,4-diamine, and 2-[2-(2-{2-[(2,5-diaminophenyl)- oxy]ethoxy } ethoxy)ethoxy]benzene- 1 ,4-diamine; 1 ,3 -Bis(N(2-Hydroxyethyl)-N-(4- amino-phenyl)amino)-2-propanol; 2,2'-[l,2-Ethanediyl-bis-(oxy-2,l-ethanediyloxy)]-bis- benzene- 1 ,4-diamine; N,N-Bis(2-hydroxyethyl)-p-phenylinediamine; p-aminophenol derivatives such as: 4-amino-phenol (commonly known as p-aminophenol), 4- methylamino-phenol, 4-amino-3 -methyl-phenol, 4-amino-2-hydroxymethyl-phenol, 4- amino-2-methyl-phenol, 4-amino- 1 -hydroxy-2-(2'-hydroxyethylaminomethyl)benzene , 4- amino-2-methoxymethyl-phenol, 5-amino-2-hydroxy-benzoic acid, l-(5-amino-2- hydroxy-phenyl)-ethane- 1 ,2-diol, 4-amino-2-(2-hydroxy-ethyl)-phenol, 4-amino-3- (hydroxymethyl)phenol, 4-amino-3-fluoro-phenol, 4-amino-2-(aminomethyl)-phenol, 4- amino-2-fluoro-phenol; 1 -Hydroxy-2,4-diaminobenzene; 1 -(2'-Hydroxyethyloxy)-2,4- diaminobenzene; 2,4-Diamino-5-methylphenetol; o-phenylenediamine derivatives such as: 3,4-Diaminobenzoic acid and salts thereof; o-aminophenol derivatives such as: 2- amino-phenol (commonly known as o-aminophenol), 2,4-diaminophenol, 2-amino-5- methyl-phenol, 2-amino-6-methyl-phenol, N-(4-amino-3-hydroxy-phenyl)-acetamide, and 2-amino-4-methyl-phenol; and heterocyclic derivatives such as: pyrimidine-2,4,5,6- tetramine (commonly known as 2,4,5, -tetraaminopyridine), 1 -methyl- lH-pyrazole-4,5- diamine, 2-(4,5-diamino-lH-pyrazol-l-yl)ethanol, N2,N2-dimethyl-pyridine-2,5-diamine, 2-[(3-amino-6-methoxypyridin-2-yl)amino]ethanol, 6-methoxy-N2-methyl-pyridine-2,3- diamine, 2,5,6-triaminopyrimidin-4(lH)-one, pyridine-2,5-diamine, 1-isopropyl-lH- pyrazole-4,5-diamine, 1 -(4-methylbenzyl)- 1 H-pyrazoIe-4,5-diamine, 1 -(benzyl)- 1 H- pyrazole-4,5 -diamine, l-(4-chlorobenzyl)-lH-pyrazole-4,5-diamine, pyrazolo[l,5-a]- pyrimidine-3,7-diamine, 5,6,7-trimethylpyrazolo[l,5-a]pyrimidin-3-ylamine hydrochloride, 7-methylpyrazolo[l,5-a]pyrimidin-3-ylamine hydrochloride, 2,5,6,7- teramethyl-pyrazolo[l,5-a]pyrimidin-3-ylamine hydrochloride, 5,7-di-tert- butylpyrazolo[l ,5-a]pyrimidin-3-ylamine hydrochloride, 5,7-di-trifluoromethyl- pyrazolo[l,5-a]pyrimidin-3-ylamine hydrochloride, 2-methylpyrazolo[l,5-a]pyrimidin- 3,7-diamine hydrochloride; 4-Hydroxy-2,5,6-triaminopyrimidine; l-(2'hydroxyethyl)- amino-3,4-methylene dioxybenzene; and l-Hydroxyethyl-4,5-diaminopyrazole sulphate. Additional developers are selected from the group consisting of N-(3- furylmethyl)benzene- 1 ,4-diamine; N-Thiophen-3 -ylmethyl-benzene- 1 ,4-diamine; N-(2- furylmethyl)benzene- 1 ,4-diamine; Ν-Thiophen-2 -ylmethyl-benzene- 1 ,4-diamine; 4- Hydroxy-benzoic acid (2,5-diamino-benzylidene)-hydrazide; 3-(2,5-Diamino-phenyl)-N- ethyl-acrylamide; 2-[3-(3-Amino-phenylamino)-propenyl]-benzene-l,4-diamine; 2-[3-(4- Amino-phenylamino)-propenyl]-benzene- 1 ,4-diamine; 2-(6-Methyl-pyridin-2-yl)- benzene- 1 ,4-diamine; 2-Pyridin-2-yl-benzene- 1 ,4-diamine; 2-[3-(4-Amino-phenylamino)- propenyl]-benzene- 1,4-diamine; 2-[3-(3-Amino-phenylamino)-propenyl]-benzene- 1,4- diamine; 3-(2,5-Diamino-phenyl)-N-ethyl-acrylamide; 2-Thiazol-2-yl-benzene- 1 ,4- diamine; 4-Hydroxy-benzoic acid (2,5-diamino-benzylidene)-hydrazide; 3'-Fluoro- biphenyl-2,5-diamine; 2-Propenyl-benzene- 1 ,4-diamine; 2'-Chloro-biphenyl-2,5-diamine; N-Thiophen-3 -ylmethyl-benzene- 1 ,4-diamine; N-(3-furylmethyl)benzene- 1 ,4-diamine; 4'- Methoxy-biphenyl-2,5-diamine; Ν-(4-Amino-benzyl)-benzene- 1 ,4-diamine; 2-Methyl-5- [(l-H-pyrrol-2-ylmethyl)-amino]-phenol; 5-[(Furan-2-ylmethyl)-amino]-2-methyl- phenol; 5-Isopropylamino-2-methyl-phenol; Biphenyl-2,4,4'-triamine hydrochloride; 5- (4-Amino-phenyl)aminomethyl-benzene-l,3-diamine hydrochloride; 5-
Phenylaminomethyl-benzene-l,3-diamine hydrochloride; 2-[4-Amino-2-(3,5-diamino- benzylamino)-phenoxy]-ethanol hydrochloride; 5-(3-Amino-phenyl)aminomethyl- benzene- 1 ,3-diamine hydrochloride; N-(2- Amino-benzyl)-benzene- 1 ,3 -diamine hydrochloride; N-Furan-2-ylmethyl-benzene- 1,3 -diamine hydrochloride; 2-[(3-Amino- phenylamino)-methyl]-phenol hydrochloride; 4-Amino-2-propylaminomethyl-phenol; hydrochloride; N-Benzo[l,3]dioxol-5-ylmethyl-benzene- 1,3 -diamine hydrochloride; N- [4-Amino-2-(2-hydroxy-ethyl)-2H-pyrazol-3-yl]-3-(5-amino-2-hydroxy-phenyl)- acrylamide; hydrochloride; 4-Amino-2-(isopropylamino-methyl)-phenol; hydrochloride; 4-Thiophen-3-yl-benzene- 1,3 -diamine; hydrochloride hydrochloride; 5-
Phenylaminomethyl-benzene- 1 ,3-diamine hydrochloride; 5-(3-Amino- phenyl)aminomethyl-benzene- 1,3 -diamine hydrochloride; 4-Thiophen-3-yl-benzene-l,3- diamine; hydrochloride; 2',4'-Diamino-biphenyl-4-ol; hydrochloride; 5-Cyclobutylamino- 2-methyl-phenol; 5-Cyclobutylamino-2-methyl-phenol; 4-Amino-2-(pyridin-3- ylaminomethyl)-phenol; 5-(3-Amino-phenyl)aminomethyl-benzene- 1 ,3-diamine hydrochloride; 5- Allylaminomethyl-benzene- 1,3 -diamine hydrochloride; N-(4-Amino- benzyl)-benzene-l,3-diamine hydrochloride; N-Benzyl-benzene- 1,3 -diamine hydrochloride; 3-[(3-Amino-phenylamino)-methyl]-phenol hydrochloride; N-(4- Methoxy-benzyl)-benzene- 1 ,3-diamine hydrochloride; N-Thiophen-2-ylmethyl-benzene- 1 ,3-diamine hydrochloride; 4-Amino-2-[(2-hydroxy-5-nitro-phenylamino)-methyl]- phenol; hydrochloride; 2',4'-Diamino-biphenyl-4-ol hydrochloride; Biphenyl-2,4,4'- triamine; 5-(4-Amino-phenyl)aminomethyl-benzene- 1,3 -diamine hydrochloride; 2-[4- Amino-2-(3 ,5-diamino-benzylamino)-phenoxy]-ethanol hydrochloride; 5-
Allylaminomethyl-benzene- 1,3 -diamine hydrochloride; 5-(3-Amino- phenyl)aminomethyl-benzene- 1 ,3-diamine hydrochloride; N-(4-Amino-benzyl)-benzene- 1,3-diamine hydrochloride; N-Benzyl-benzene-l,3-diamine hydrochloride; 3-[(3-Amino- phenylamino)-methyl]-phenol hydrochloride; N-(2- Amino-benzyl)-benzene- 1 ,3-diamine hydrochloride; N-(4-Methoxy-benzyl)-benzene- 1,3 -diamine hydrochloride; N-Furan-2- ylmethyl-benzene-l,3-diamine hydrochloride; 2-[(3-Amino-phenylamino)-methyl]- phenol hydrochloride; N-Thiophen-2-ylmethyl-benzene-l,3-diamine hydrochloride; N- Benzo[ 1 ,3]dioxol-5-ylmethyl-benzene- 1 ,3-diamine hydrochloride; N-[4- Amino-2-(2- hydroxy-ethyl)-2H-pyrazol-3-yl]-3-(5-amino-2-hydroxy-phenyl)-acrylamide hydrochloride; 4-Amino-2-propylaminomethyl-phenol; hydrochloride; 4-Amino-2- (isopropylamino-methyl)-phenol hydrochloride; 4-Amino-2-[(2-hydroxy-5-nitro- phenylamino)-methyl]-phenol hydrochloride; 2-Methyl-5-[(l -H-pyrrol^-ylmethy - aminoj'-phenol; 5-[(Furan-2-ylmethyl)-amino]-2 -methyl-phenol; 5-Isopropylamino-2- methyl-phenol; 5-Cyclobutylamino-2-methyl-phenol; 4-Amino-2-(pyridin-3- ylaminomethyl)-phenol; and 5-Cyclobutylamino-2-methyl-phenol. Preferred developers include but are not limited to: p-phenylenediamine derivatives such as: 2-methyl-benzene- 1,4-diamine; benzene- 1,4-diamine; l-(2,5- diamino-phenyl)-ethanol; 2-(2,5-diamino-phenyl)-ethanol; N-(2-methoxyethyl)benzene- 1 ,4-diamine; 2-[(4-amino-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol; 1 -(2,5- diaminophenyl)ethane-l,2-diol; l-(2'-Hydroxyethyl)-2,5-diaminobenzene; l,3-Bis(N(2- Hydroxyethyl)-N-(4-amino-phenyl)amino)-2-propanol; 2,2'-[l,2-Ethanediyl-bis-(oxy-2,l- ethanediyloxy)]-bis-benzene- 1 ,4-diamine; N,N-Bis(2-hydroxyethyl)-p-phenylinediamine; and mixtures thereof; p-aminophenol derivatives such as: 4-amino-phenol, 4- methylamino-phenol, 4-amino-3 -methyl-phenol, 4-amino-2-methoxymethyl-phenol; l-(5- amino-2-hydroxy-phenyl)-ethane- 1 ,2-diol; 1 -Hydroxy-2,4-diaminobenzene; 1 -(2'- Hydroxyethyloxy)-2,4-diaminobenzene; 4-Amino-2-aminomethylphenol; 2,4-Diamino-5- methylphenetol; 4- Amino- 1 -hydroxy-2-(2'-hydroxyethylaminomethyl)benzene; 1 - methoxy-2-amino-4-(2'hydroxyethylamino)benzene; 5-aminosalicylic acid and salts thereof; and mixtures thereof; o-phenylenediamine derivatives such as: 3,4- Diaminobenzoic acid and salts thereof; o-aminophenol derivatives such as: 2-amino- phenol, 2-amino-5-methyl-phenol, 2-amino-6-methyl-phenol, N-(4-amino-3-hydroxy- phenyl)-acetamide; 2-amino-4-methyl-phenol; and mixtures thereof; and heterocyclic derivatives such as: pyrimidine-2,4,5,6-tetramine; 1 -methyl- lH-pyrazole-4,5-diamine; 2- (4,5-diamino- 1 H-pyrazol- 1 -yl)ethanol; 1 -(4-methylbenzyl)- 1 H-pyrazole-4,5-diamine; 1 - (benzyl)- lH-pyrazole-4,5-diamine; N2,N2-dimethyl-pyridine-2,5-diamine; 4-Hydroxy- 2,5,6-triaminopyrimidine; 1 -(2 'hydroxy ethyl)-amino-3,4-methylene dioxybenzene; and 1- Hydroxyethyl-4,5-diaminopyrazole sulphate; and mixtures thereof. More preferred developers include: 2 -methyl-benzene- 1,4-diamine; benzene- 1,4- diamine; N,N-Bis(2-hydroxyethyl)-p-phenylenediamine; 4-amino-phenol; 4- methylamino-phenol; 4-amino-3-methyl-phenol; l-Hydroxy-2,4-diaminobenzene; 2- amino-phenol; 2-amino-5-methyl-phenol; 2-amino-6-methyl-phenol; 1 -methyl- 1H- pyrazole-4,5-diamine; l-Hydroxyethyl-4,5-diaminopyrazole sulphate; 2-(4,5-diamino- lH-pyrazol-l-yl)ethanol; and mixtures thereof. C. Auxiliary Couplers Suitable couplers for use in the compositions described herein include, but are not limited to: phenols, resorcinol and naphthol derivatives such as: naphthalene- 1,7-diol, benzene- 1,3 -diol, 4-chlorobenzene- 1,3 -diol, naphthalen-1-ol, 2-methyl-naphthalen-l-ol, naphthalene- 1,5-diol, naphthalene-2,7-diol, benzene- 1,4-diol, 2-methyl-benzene-l,3-diol, 7-amino-4-hydroxy-naphthalene-2-sulfonic acid, 2-isopropyl-5-methylphenol, 1,2,3,4- tetrahydro-naphthalene- 1 ,5-diol, 2-chloro-benzene- 1 ,3 -diol, 4-hydroxy-naphthalene- 1 - sulfonic acid, benzene- 1, 2,3 -triol, naphthalene-2,3-diol, 5-dichloro-2-methylbenzene-l,3- diol, 4,6-dichlorobenzene-l,3-diol, 2,3-dihydroxy-[l,4]naphthoquinone; and 1-Acetoxy- 2-methylnaphthalene; m-phenylenediamines such as: 2,4-diaminophenol, benzene-1,3- diamine, 2-(2,4-diamino-phenoxy)-ethanol, 2-[(3-amino-phenyl)-(2-hydroxy-ethyl)- amino]-ethanol, 2-mehyl-benzene-l ,3-diamine, 2-[[2-(2,4-diamino-phenoxy)-ethyl]-(2- hydroxy-ethyl)-amino]-ethanol, 4- {3-[(2,4-diaminophenyl)oxy]propoxy}benzene- 1 ,3- diamine, 2-(2,4-diamino-phenyl)-ethanol, 2-(3-amino-4-methoxy-phenylamino)-ethanol, 4-(2-amino-ethoxy)-benzene-l,3-diamine, (2,4-diamino-phenoxy)-acetic acid, 2-[2,4- diamino-5-(2-hydroxy-ethoxy)-phenoxy]-ethanol, 4-ethoxy-6-methyl-benzene-l,3- diamine, 2-(2,4-diamino-5-methyl-phenoxy)-ethanol, 4,6-dimethoxy-benzene-l,3- diamine, 2-[3-(2-hydroxy-ethylamino)-2-methyl-phenylamino]-ethanol, 3-(2,4-diamino- phenoxy)-propan- 1 -ol, N-[3-(dimethylamino)phenyl]urea, 4-methoxy-6-methylbenzene- 1,3-diamine, 4-fluoro-6-methylbenzene- 1,3 -diamine, 2-({3-[(2-hydroxyethyl)amino]-4,6- dimethoxyphenyl}-amino)ethanol, 3-(2,4-diaminophenoxy)-propane-l,2-diol, 2-[2- amino-4-(methylamino)-phenoxy]ethanol, 2-[(5-amino-2-ethoxy-phenyl)-(2-hydroxy- ethyl)-amino]-ethanol, 2-[(3-aminophenyl)amino]ethanol, 2,4-Diamino-5-(2'- hydroxyethyloxy)toluene; N,N-Dimethyl-3-ureidoaniline; N-(2-aminoethyl)benzene- 1 ,3- diamine, 4- {[(2,4-diamino-phenyl)oxy]methoxy} -benzene- 1,3 -diamine, l-methyl-2,6- bis(2-hydroxyethylamino)benzene; and 2,4-dimethoxybenzene-l,3-diamine; m- aminophenols such as: 3-amino-phenol, 2-(3-hydroxy-4-methyl-phenylamino)-acetamide, 2-(3-hydroxy-phenylamino)-acetamide, 5-amino-2-methyl-phenol, 5-(2-hydroxy- ethylamino)-2-methyl-phenol, 5 -amino-2 ,4-dichloro-phenol, 3 -amino-2-methy 1-phenol, 3-amino-2-chloro-6-methyl-phenol, 5-amino-2-(2-hydroxy-ethoxy)-phenol, 2-chloro-5- (2,2,2-trifluoro-ethylamino)-phenol, 5-amino-4-chloro-2 -methyl-phenol, 3- cyclopentylamino-phenol, 5-[(2-hydroxyethyl)amino]-4-methoxy-2-methylphenol, 5- amino-4-methoxy-2-methylphenol, 3-(dimethylamino)phenol, 3-(diethylamino)phenol, 5- amino-4-fluoro-2-methylphenol, 5-amino-4-ethoxy-2-methylphenol, 3-amino-2,4- dichloro-phenol, 3-[(2-methoxyethyl)amino]phenol, 3-[(2-hydroxyethyl)amino]phenol, 5- amino-2-ethyl-phenol, 5-amino-2-methoxyphenol, 5-[(3-hydroxy-propyl)amino]-2- methylphenol, 3-[(3-hydroxy-2-methylphenyl)-amino]propane- 1 ,2-diol, 3-[(2- hydroxyethyl)amino]-2-methylphenol; l-Methyl-2-hydroxy-4-(2'-hydroxyethyl)amino- benzene; 1 ,3-Bis-(2,4-Diaminophenoxy)propane; 1 -Hydroxy-2-methyl-5-amino-6- chlorobenzene; and heterocyclic derivatives such as: 3,4-dihydro-2H-l,4-benzoxazin-6- ol, 4-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, 6-methoxyquinolin-8-amine, 4- methylpyridine-2,6-diol, 2,3-dihydro-l,4-benzodioxin-5-ol, l,3-benzodioxol-5-ol, 2-(l,3- benzodioxol-5-ylamino)ethanol, 3,4-dimethylpyridine-2,6-diol, 5-chloropyridine-2,3-diol, 2,6-dimethoxypyridine-3,5-diamine, l,3-benzodioxol-5-amine, 2-{[3,5-diamino-6-(2- hydroxy-ethoxy)-pyridin-2-yl]oxy}-ethanol, lH-indol-4-ol, 5-amino-2,6- dimethoxypyridin-3-ol, lH-indole-5,6-diol, lH-indol-7-ol, lH-indol-5-ol, lH-indol-6-ol, 6-bromo-l,3-benzodioxol-5-ol, 2-aminopyridin-3-ol, pyridine-2,6-diamine, 3-[(3,5- diaminopyridin-2-yl)oxy]propane-l,2-diol, 5-[(3,5-diaminopyridin-2-yl)oxy]pentane-l,3- diol, lH-indole-2,3-dione, indoline-5,6-diol, 3,5-dimethoxypyridine-2,6-diamine, 6- methoxypyridine-2,3-diamine; 3,4-dihydro-2H-l,4-benzoxazin-6-amine; 4-hydroxy-N- methylindole, lH-5-methylpyrazol-5-one, l-phenyl-3-methylpyrazol-5-one, 2,6- dimethylpyrazolo[ 1 ,5-b]- 1 ,2,4-triazole, 2,6-dimethyl[3 ,2-c]- 1 ,2,4-triazole, 6- methylpyrazolo-[l ,5-a]benzimidazole, 2,6-dihydroxypyridine, 2,6-dihydroxy-3,4- dimethylpyridine, 5-methylpyrazolo[5,l-e]-l,2,3-triazole, 5-methyl-6-chloropyrazolo[5,l- e]-l,2,3,-triazole, 5-phenylpyrazolo[5,l-e]-l,2,3-triazole and its addition salts, lH-2,6- dimethylpyrazolo[ 1 ,5-b]- 1 ,2,4-triazole tosylate, 7,8-dicyano-4-methylimidazolo-[3,2- a]imidazole, 2,7-dimethylpyrazolo[l,5-a]pyrimidin-5-one, 2,5-dimethylpyrazolo[l,5- a]pyrimidin-7-one, and 2-methyl-5-methoxymethyl-pyrazolo[l,5-a]pyrimidin-7-one; 6- Hydroxybenzomoφholine; and 3-Amino-2-methylamino-6-methoxypyridine; 1-Phenyl- 3-methyl-5-pyrazolone-2,4-dihydro-5,2-phenyl-3H-pyrazole-3-one. Additional couplers are selected from the group consisting of N-(3- furylmethyl)benzene- 1 ,4-diamine; Ν-Thiophen-3-ylmethyl-benzene- 1 ,4-diamine; N-(2- fuιylmethyl)benzene- 1 ,4-diamine; Ν-Thiophen-2 -ylmethyl-benzene- 1 ,4-diamine; 4- Hydroxy-benzoic acid (2,5-diamino-benzylidene)-hydrazide; 3-(2,5-Diamino-phenyl)-N- ethyl-acrylamide; 2-[3-(3-Amino-phenylamino)-propenyl]-benzene- 1 ,4-diamine; 2-[3-(4- Amino-phenylamino)-propenyl]-benzene- 1 ,4-diamine; 2-(6-Methyl-pyridin-2-yl)- benzene- 1,4-diamine; 2-Pyridin-2-yl-benzene- 1,4-diamine; 2-[3-(4-Amino-phenylamino)- propenylj-benzene- 1,4-diamine; 2-[3-(3-Amino-phenylamino)-propenyl]-benzene- 1,4- diamine; 3-(2,5-Diamino-phenyl)-N-ethyl-acrylamide; 2 -Thiazol-2-yl -benzene- 1 ,4- diamine; 4-Hydroxy-benzoic acid (2,5-diamino-benzylidene)-hydrazide; 3'-Fluoro- biphenyl-2,5-diamine; 2-Propenyl-benzene- 1 ,4-diamine; 2'-Chloro-biphenyl-2,5-diamine; N-Thiophen-3 -ylmethyl-benzene- 1 ,4-diamine; N-(3-furylmethyl)benzene- 1 ,4-diamine; 4'- Methoxy-biphenyl-2,5-diamine; Ν-(4-Amino-benzyl)-benzene- 1 ,4-diamine; 2-Methyl-5- [(l-H-pyrrol-2-ylmethyl)-amino]-phenol; 5-[(Furan-2-ylmethyl)-amino]-2-methyl- phenol; 5-Isopropylamino-2-methyl-phenol; Biphenyl-2,4,4'-triamine hydrochloride; 5- (4-Amino-phenyl)aminomethyl-benzene- 1 ,3-diamine hydrochloride; 5-
Phenylaminomethyl-benzene- 1,3 -diamine hydrochloride; 2-[4-Amino-2-(3,5-diamino- benzylamino)-phenoxy]-ethanol hydrochloride; 5-(3-Amino-phenyl)aminomethyl- benzene- 1 ,3-diamine hydrochloride; N-(2-Amino-benzyl)-benzene- 1 ,3-diamine hydrochloride; N-Furan-2-ylmethyl-benzene-l,3-diamine hydrochloride; 2-[(3-Amino- phenylamino)-methyl] -phenol hydrochloride; 4-Amino-2-propylaminomethyl-phenol; hydrochloride; N-Benzo[l,3]dioxol-5-ylmethyl-benzene-l,3-diamine hydrochloride; N- [4-Amino-2-(2-hydroxy-ethyl)-2H-pyrazol-3-yl]-3-(5-amino-2-hydroxy-phenyl)- acrylamide; hydrochloride; 4-Amino-2-(isopropylamino-methyl)-phenol; hydrochloride; 4-Thiophen-3-yl-benzene-l,3-diamine; hydrochloride hydrochloride; 5-
Phenylaminomethyl-benzene- 1 ,3-diamine hydrochloride; 5-(3- Amino- phenyl)aminomethyl-benzene-l,3-diamine hydrochloride; 4-Thiophen-3-yl-benzene-l,3- diamine; hydrochloride; 2',4'-Diamino-biphenyl-4-ol; hydrochloride; 5-Cyclobutylamino- 2-methyl-phenol; 5-Cyclobutylamino-2-methyl-phenol; 4-Amino-2-(pyridin-3- ylaminomethyl)-ρhenol; 5-(3-Amino-phenyl)aminomethyl-benzene- 1 ,3-diamine hydrochloride; 5-Allylaminomethyl-benzene-l,3-diamine hydrochloride; N-(4-Amino- benzyl)-benzene- 1 ,3-diamine hydrochloride; N-Benzyl-benzene- 1 ,3-diamine hydrochloride; 3-[(3-Amino-phenylamino)-methyl]-phenol hydrochloride; N-(4- Methoxy-benzyl)-benzene- 1 ,3-diamine hydrochloride; N-Thiophen-2-ylmethyl-benzene- 1 ,3-diamine hydrochloride; 4-Amino-2-[(2-hydroxy-5-nitro-phenylamino)-methyl]- phenol; hydrochloride; 2',4'-Diamino-biphenyl-4-ol hydrochloride; Biphenyl-2,4,4'- triamine; 5-(4-Amino-phenyl)aminomethyl-benzene-l,3-diamine hydrochloride; 2-[4- Amino-2-(3,5-diamino-benzylamino)-phenoxy]-ethanol hydrochloride; 5-
Allylaminomethyl-benzene-l,3-diamine hydrochloride; 5-(3-Amino- phenyl)aminomethyl-benzene- 1 ,3-diamine hydrochloride; N-(4-Amino-benzyl)-benzene- 1,3-diamine hydrochloride; N-Benzyl-benzene- 1,3 -diamine hydrochloride; 3-[(3-Amino- phenylamino)-methyl]-phenol hydrochloride; N-(2-Amino-benzyl)-benzene- 1 ,3-diamine hydrochloride; N-(4-Methoxy-benzyl)-benzene- 1,3 -diamine hydrochloride; N-Furan-2- ylmethyl-benzene- 1 ,3-diamine hydrochloride; 2-[(3-Amino-phenylamino)-methyl]- phenol hydrochloride; N-Thiophen-2-ylmethyl-benzene-l,3-diamine hydrochloride; N- Benzo[l,3]dioxol-5-ylmethyl-benzene-l,3-diamine hydrochloride; N-[4-Amino-2-(2- hydroxy-ethyl)-2H-pyrazol-3-yl]-3-(5-amino-2-hydroxy-phenyl)-acrylamide hydrochloride; 4-Amino-2-propylaminomethyl-phenol; hydrochloride; 4-Amino-2- (isopropylamino-methyl)-phenol hydrochloride; 4-Amino-2-[(2-hydroxy-5-nitro- phenylamino)-methyl] -phenol hydrochloride; 2-Methyl-5-[(l-H-pyrrol-2-ylmethyl)- amino]-phenol; 5-[(Furan-2-ylmethyl)-amino]-2-methyl-phenol; 5-Isopropylamino-2- methyl-phenol; 5-Cyclobutylamino-2-methyl-phenol; 4-Amino-2-(pyridin-3- ylaminomethyl)-phenol; and 5-Cyclobutylamino-2 -methyl-phenol. Preferred couplers include but are not limited to: phenol, resorcinol, and naphthol derivatives such as: naphthalene- 1,7-diol, benzene- 1,3-diol, 4-chlorobenzene- 1,3-diol, naphthalen-1-ol, 2-methyl-naphthalen-l-ol, naphthalene- 1,5-diol, naphthalene-2,7-diol, benzene- 1,4-diol, 2-methyl-benzene- 1,3-diol, and 2-isopropyl-5-methylphenol; 1,2,4- Trihydroxybenzene; l-Acetoxy-2-methylnaphthalene;and mixtures thereof; m- phenylenediamine derivatives such as: benzene- 1,3 -diamine, 2-(2,4-diamino-phenoxy)- ethanol, 4- {3-[(2,4-diaminophenyl)oxy]propoxy }benzene- 1 ,3-diamine, 2-(3-amino-4- methoxy-phenylamino)-ethanol, 2-[2,4-diamino-5-(2-hydroxy-ethoxy)-phenoxy]- ethanol, and 3-(2,4-diamino-phenoxy)-propan-l-ol; 2,4-Diamino-5-(2'- hydroxyethyloxy)toluene; N,N-Dimethyl-3-ureidoaniline; 2,4-Diamino-5- fluorotoluenesulfatehydrate; 1 -methyl-2,6-bis(2-hydroxyethylamino)benzene; and mixtures thereof; m-aminophenol derivatives such as: 3-amino-phenol, 5-amino-2- methyl-phenol, 5-(2-hydroxy-ethylamino)-2-methyl-phenol, and 3-amino-2-methyl- phenol; 1 -Methyl-2-hydroxy-4-(2'-hydroxyethyl)aminobenzene; 1 -Hydroxy-3-amino-2,4- dichlorobenzene; 1 ,3 -Bis-(2,4-Diaminophenoxy)propane; 1 -Hydroxy-2-methyl-5-amino- 6-chlorobenzene; 5-Amino-4-chloro-2-methylphenol; and mixtures thereof; and heterocyclic derivatives such as: 3,4-dihydro-2H-l,4-benzoxazin-6-ol, 4-methyI-2- phenyl-2,4-dihydro-3H-pyrazol-3-one, 1 ,3-benzodioxol-5-ol, 1 ,3-benzodioxol-5-amine, lH-indol-4-ol, lH-indole-5,6-diol, lH-indol-7-ol, lH-indol-5-ol, lH-indol-6-ol, 1H- indole-2,3-dione, pyridine-2,6-diamine, 2-aminopyridin-3-ol, 4-hydroxy-N-methylindole, lH-5-methylpyrazol-5-one, l-phenyl-3-methylpyrazol-5-one, 2,6-dimethylpyrazolo[l ,5- b]-l,2,4-triazole, 2,6-dimethyl[3,2-c]-l,2,4-triazole, 6-methylpyrazolo-[l,5- a]benzimidazole; 2,6-dihydroxypyridine; 2,6-dihydroxy-3,4-dimethylpyridine; 6- Hydroxybenzomoφholine; 2,6-Dihydroxy-3 ,4-dimethylpyridine; 3 ,5-Diamino-2,6- dimethoxypyridine; 3-Amino-2-methylamino-6-methoxypyridine; 1 -Phenyl-3-methyl-5- pyrazolone-2,4-dihydro-5,2-phenyl-3H-pyrazole-3-one; and mixtures thereof. More preferred couplers include: benzene- 1,3-diol; 4-chlorobenzene- 1,3-diol; 2- methyl-benzene- 1,3-diol; benzene- 1,3-diamine; 3-amino-phenol; 5-amino-2-methyl- phenol; 1 -Methyl-2-hydroxy-4-(2'-hydroxyethyl)aminobenzene; 4-methyl-2-phenyl-2,4- dihydro-3H-pyrazol-3-one; 2-aminopyridin-3-ol; l-phenyl-3-methylpyrazol-5-one; 1- Phenyl-3-methyl-5-pyrazolone-2,4-dihydro-5,2-phenyl-3H-pyrazole-3-one; and mixtures thereof. Additional preferred developers and couplers include 5-methoxymethyl-2- aminophenol, 5-ethyl-2-aminophenol, 5-phenyl-2-aminophenol, and 5-cyanoethyl-2- aminophenol. Further additional preferred developers and couplers include: 5-membered heteroaromatic keratin dyeing compounds with one, two, or three heteroatoms relating to the following compounds: wherein Z is selected from the group consisting of S and O; wherein Y is selected from the group consisting of NA1, S and O; Bicyclic 5-5 heteroaromatic compounds having a ring junction nitrogen according to the following formulas:
wherein Y is selected from the group consisting of S and O; Tricyclic 5-6-5 heteroaromatic keratin dyeing compounds having two heteroatoms according to the following formulas:
(I) (II)
(III) (IV) wherein Y and Z are selected from the group consisting of NA1, S, and O; Bicyclic 5-6 heteroaromatic keratin dyeing compounds with one ring junction nitrogen and one or two extra heteroatoms according to the following formulas:
(IV) (V) (VI)
(XIX) (XX) (XXI) (XXII) (XXIII) (XXIV)
Tricyclic fused 6-5-6 heteroaromatic keratin dyeing compounds having one heteroatom according to the following formula:
wherein Y is independently selected from the group consisting of NA1, S and O; 5-membered aza heteroaromatic keratin dyeing compounds with an N-hydroxy or N- amino group and derivatives thereof, according to the following formulas:
1 II wherein Bi, B2, B3, and B4 are selected from the group consisting of CH and N; wherein the corresponding R1, R2, R3,and R4 is absent when B is N; Bicyclic 5-6 systems of aza heteroaromatic keratin dyeing compounds wherein the 5- membered rings have one to three nitrogen atoms and an N-hydroxy or N-amino group and derivatives thereof, according to the following formulas: I II wherein Bj and B2 are independently selected from CH or N; wherein the corresponding R1 and R2 is absent when B is N; Bicyclic fused 5-5-membered aza heteroaromatic keratin dyeing compounds with an N- hydroxy or N-amino group and derivatives thereof, according to the following formulas:
Bicyclic fused 5-5-membered aza heteroaromatic keratin dyeing compounds having a ring junction nitrogen and an N-hydroxy or N-amino group and derivatives thereof, according to the following formulas:
Vllb.d Villa, c Vlllb,d
IXa,c,e IXb,d,f Xa,c Xb,d
XVIb XVIIa XVIIb
XVIIIa XVIIIb
Bicyclic fused 5-5-membered aza heteroaromatic keratin dyeing compounds having a ring junction nitrogen and an N-hydroxy or N-amino group and derivatives thereof, according to the following formulas:
B wherein Bi, B2, B , B4j and B5 are selected from the group consisting of CH and N; wherein the corresponding R1,R2, R3, R4 , and R5 is absent when B is N; wherein all of the aforementioned R groups are the same or different and are selected from the group consisting of: (a) C-linked monovalent substituents selected from the group consisting of: (i) substituted or unsubstituted, straight or branched, alkyl, mono- or poly- unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefinic systems, (ii) substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems, and (iii) substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems; wherein said systems of (i), (ii) and (iii) comprise from about 1 to about 10 carbon atoms and from about 0 to about 5 heteroatoms selected from the group consisting of O, S, N, P, and Si; wherein substituents of the substituted systems of the C-linked monovalent substituents are selected from the group consisting of amino, hydroxyl, alkylamino (linear, branched, or cyclic C1-C5), dialkylamino (linear, branched, or cyclic C1-C5), hydroxyalkylamino (linear, branched, or cyclic C1-C5), dihydroxyalkylamino (linear, branched, or cyclic C1-C5), arylamino or substituted arylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), heteroarylamino or substituted heteroarylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), arylmethylamino or substituted arylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), and heteroarylmethylamino or substituted heteroarylmethylamino (substituents are halogen, C1-C5 alkyl, C1-C5 alkoxy, trifluoromethyl, amino, C1-C5 alkylamino), (b) S-linked monovalent substituents selected from the group consisting of SA1, SOzA1, SO3A1, SSA1, SOA1, SO2NA'A2, SNA'A2, and SONA'A2; (c) O-linked monovalent substituents selected from the group consisting of OA1, and ONA!A2; (d) N-linked monovalent substituents selected from the group consisting of NA'A2, (NA!A2A3)+, NA!OA2, NA'SA2, NO2, N=NA!, N=NOA1, and NA1CN, NA NA2A3; (e) monovalent substituents selected from the group consisting of COO A1, CONA1 ., CONA'COA2, C(=NA1)NA1A2, CN, and X; (f) fluoroalkyl monovalent substituents selected from the group consisting of mono-, poly-, and per-fluoro alkyl systems comprising from about 1 to about 12 carbon atoms and from about 0 to about 4 heteroatoms; and (g) hydrogen, wherein A1, A2, and A3 are monovalent and are independently selected from the group consisting of: H; substituted or unsubstituted, straight or branched, alkyl, mono- or poly-unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefinic systems; substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems; and substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems, or A1 and A2 together with nitrogen atoms to which they are bound form a ring; wherein said systems comprise from about 1 to about 10 carbon atoms and from about 0 to about 5 heteroatoms selected from the group consisting of O, S, N, P, and Si; wherein X is a halogen selected from the group consisting of F, CI, Br, and I.
D. Direct Dyes The inventive compositions may also comprise compatible direct dyes, in an amount sufficient to provide additional coloring, particularly with regard to intensity. Typically, such an amount will range from 0.05% to 4%, by weight, of the composition. Suitable direct dyes include but are not limited to: Acid Yellow 1, Acid Orange 3, Disperse Red 17, Basic Brown 17, Acid Black 52, Acid Black 1, Disperse Violet 4, 4- Nitro-o-Phenylenediamine, 2-Nitro-p-Phenylenediamine, Picramic Acid, HC Red No. 13, l,4-Bis-(2'-Hydroxyethyl)-amino-2-nitrobenzene, HC Yellow No. 5, HC Red No. 7, HC Blue No. 2, HC Yellow No. 4, HC Yellow No. 2, HC Orange No. 1, HC Red No. 1, 2- Chloro-5-nitro-N-Hydroxyethyl-p-phenylenediamine, HC Red No. 3, 4-Amino-3- nitrophenol, 2-Hydroxyethylamino-5-nitroanisole, 3-nitro-p-Hydroxyethylaminophenol, 2-amino-3-nitrophenol, 6-nitro-o-toluidine, 3-methylamino-4-nitrophenoxyethanol, 2- nitro-5-glycerymethylanaline, HC Yellow No. 11, HC Violet No. 1, HC Orange No. 2, HC Orange No. 3, HC Yellow No. 9, 4-Nitrophenyl Aminoethylurea, HC Red No. 10, HC Red No. 11, 2-Hydroxyethyl picramic acid, HC Blue No. 12, HC Yellow No. 6, Hydroxyethyl-2-nitiO-p-toluidine, HC Yellow No. 12, HC Blue No. 10, HC Yellow No. 7, HC Yellow No. 10, HC Blue No. 9, N-ethy 1-3 -nitro PABA, 4-amino-2-nitrophenyl- amine-2'-carboxylic acid, 2-chloro-6-ethylamino-4-nitrophenol, 6-Nitro-2,5- pyridinediamine, HC Violet No. 2, 2-amino-6-chloro-4-nitrophenol, 4- hydroxypropylamino-3-nitrophenol, HC Yellow No. 13, l,2,3,4-Tetrahydro-6- nitrochinoxalin, HC Red No. 14, HC Yellow No. 15, HC Yellow No. 14, 3-Amino-6- methylamino-2-nitropyridine, 2,6-diamino-3-((pyridine-3-yl)azo)pyridine, Basic Red No. 118, Basic Orange No. 69, N-(2-nitro-4-aminophenyl)-allylamine, 4-[(4-Amino-3- methylphenyl)(4-Imino-3-methyl-2,5-Cyclohexadien-l-ylidene) Methyl]-2-Methyl- benzeneamine-Hydrochloride, lH-Imidazolium,2-[[4-(dimethyl-amino)phenyl]azo]- 1 ,3- dimethylchloride, Pyridinium, l-methyl-4-[(methylphenyl-hydrazono)methyl]-, methyl sulfate, lH-Imidazolium, 2-[(4-aminophenyl)azo]-l,3-dimethyl, chloride, Basic Red 22, Basic Red 76, Basic Brown 16, Basic Yellow 57, 7-(2',4'-Dimethyl-5'-sulfophenylazo)-5- sulfo-8-hydroxynaphthalene, Acid Orange 7, Acid Red 33, l-(3'-Nitro-5'-sulfo-6'- oxophenylazo)-oxo-naphthalene chromium complex, Acid Yellow 23, Acid Blue 9, Basic Violet 14, Basic Blue 7, Basic Blue 26, Sodium salt of mixture of mono- & disulfonic acids (mainly the latter) of quinophthlanone or 2-quinolylindandione, Basic Red 2, Basic Blue 99, Disperse Red 15, Acid Violet 43, Disperse Violet 1, Acid Blue 62, Pigment Blue 15, Acid Black 132, Basic Yellow 29, Disperse Black 9, l-(N-Methylmoφholinium- propylamino)-4-hydroxy-anthraquinone methylsulfate, HC Blue No. 8, HC Red No. 8, HC Green No. 1, HC Red No. 9, 2-Hydroxy-l,4-naphthoquinone, Acid Blue 199, Acid Blue 25, Acid Red 4, Henna Red, Indigo, Cochenille, HC Blue 14, Disperse Blue 23, Disperse Blue 3, Violet 2, Disperse Blue 377, Basic Red 51, Basic Orange 31, Basic Yellow 87, and mixtures thereof. Preferred direct dyes include but are not limited to: Disperse Black 9, HC Yellow 2, HC Yellow 4, HC Yellow 15, 4-nitro-o- phenylenediamine, 2-amino-6-chloro-4-nitrophenol, HC Red 3, Disperse Violet 1, HC Blue 2, Disperse Blue 3, Disperse Blue 377, Basic Red 51, Basic Orange 31, Basic Yellow 87, and mixtures thereof. E. Oxidizing Agent The inventive compositions may comprise an oxidizing agent, present in an amount sufficient to bleach melanin pigment in hair and/or cause formation of dye chromophores from oxidative dye precursors (including developers and/or couplers when present). Typically, such an amount ranges from 1% to 20%, preferably from 3% to 15%, more preferably from 6% to 12%, by weight, of the developer composition. Inorganic peroxygen materials capable of yielding hydrogen peroxide in an aqueous medium are preferred, and include but are not limited to: hydrogen peroxide; inorganic alkali metal peroxides (e.g. sodium periodate and sodium peroxide); organic peroxides (e.g. urea peroxide, melamine peroxide); inorganic perhydrate salt bleaching compounds (e.g. alkali metal salts of perborates, percarbonates, peφhosphates, persilicates, and persulphates, preferably sodium salts thereof), which may be incoφorated as monohydrates, tetrahydrates, etc.; alkali metal bromates; enzymes; and mixtures thereof. Preferred is hydrogen peroxide. F. Thickeners The inventive compositions may comprise a thickener in an amount sufficient to provide the composition with a viscosity so that it can be readily applied to the hair without unduly dripping off the hair and causing mess. Typically, such an amount will be at least 0.1%, preferably at least 0.5%, more preferably, at least 1%, by weight, of the composition. Preferred for use herein are salt tolerant thickeners, including but not limited to: xanthan, guar, hydroxypropyl guar, scleroglucan, methyl cellulose, ethyl cellulose (available as AQUACOTE (TM)), hydroxyethyl cellulose (NATROSOL (TM)), carboxymethyl cellulose, hydroxypropylmethyl cellulose, microcrystalline cellulose, hydroxybutylmethyl cellulose, hydroxypropyl cellulose (available as KLUCEL (TM)), hydroxyethyl ethyl cellulose, cetyl hydroxyethyl cellulose (available as NATROSOL (TM) Plus 330), N-vinylpyrollidone (available as POVIDONE (TM)), Acrylates/Ceteth- 20 Itaconate Copolymer (available as STRUCTURE (TM) 3001), hydroxypropyl starch phosphate (available as STRUCTURE (TM) ZEA), polyethoxylated urethanes or polycarbamyl polyglycol ester (e.g. PEG-150/Decyl/SMDI copolymer (available as ACULYN(TM) 44), PEG-150/Stearyl/SMDI copolymer available as ACULYN(TM) 46), trihydroxystearin (available as THIXCIN(TM)), acrylates copolymer (e.g. available as ACULYN(TM) 33) or hydrophobically modified acrylate copolymers (e.g. Acrylates / Steareth-2O Methacrylate Copolymer (available as ACULYN(TM) 22), non-ionic amphophilic polymers comprising at least one fatty chain and at least one hydrophilic unit selected from polyether urethanes comprising at least one fatty chain, and blends of Ceteth - 10 phosphate, Di-cetyl phosphate and Cetearyl alcohol (available as CRODAFOS(TM) CES). G. Chelants The inventive compositions may comprise chelants in an amount sufficient to reduce the amount of metals available to interact with formulation components, particularly oxidizing agents, more particularly peroxides. Typically such an amount will range from at least 0.25%, preferably at least 0.5%, by weight, of the composition. Suitable chelants for use herein include but are not limited to: diamine-N,N'-dipolyacid, monoamine monoamide-N,N'-dipolyacid, and N,N'-bis(2- hydroxybenzyl)ethylenediamine-N,N'-diacetic acid chelants (preferably EDDS (ethylenediaminedisuccinic acid)), carboxylic acids (preferably aminocarboxylic acids), phosphonic acids (preferably aminophosphonic acids) and polyphosphoric acids (in particular straight polyphosphoric acids), their salts and derivatives. H. pH Modifiers and Buffering agents The inventive compositions may further comprise a pH modifier and/or buffering agent in an amount that is sufficiently effective to adjust the pH of the composition to fall within a range from 3 to 13, preferably from 8 to 12, more preferably from 9 to 11. Suitable pH modifiers and/or buffering agents for use herein include, but are not limited to: ammonia, alkanolamides such as monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, dipropanolamine, tripropanolamine, tripropanolamine, 2-amino-2- methyl-1 -propanol, and 2-amino-2-hydroxymethyl-l,3,-propandiol and guanidium salts, alkali metal and ammonium hydroxides and carbonates, preferably sodium hydroxide and ammonium carbonate, and acidulents such as inorganic and inorganic acids, e.g., phosphoric acid, acetic acid, ascorbic acid, citric acid or tartaric acid, hydrochloric acid, and mixtures thereof. I. Carbonate ion source and Radical Scavenger System The inventive compositions may comprise a system comprising a source of carbonate ions, carbamate ions and or hydrocarbonate ions, and a radical scavenger, in a sufficient amount to reduce damage to the hair during the coloring process. Typically, such an amount will range from 0.1% to 15%, preferably 0.1% to 10%, more preferably 1% to 7%, by weight of the composition, of the carbonate ion, and from 0.1% to 10%, preferably from 1% to 7%, by weight of the composition, of radical scavenger. Preferably, the radical scavenger is present at an amount such that the ratio of radical scavenger to carbonate ion is from 1:1 to 1:4. The radical scavenger is preferably selected such that it is not an identical species as the alkalizing agent. Suitable sources for the ions include but are not limited to: sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, guanidine carbonate, guanidine hydrogen carbonate, lithium carbonate, calcium carbonate, magnesium carbonate, barium carbonate, ammonium carbonate, ammonium hydrogen carbonate and mixtures thereof. Preferred sources of carbonate ions are sodium hydrogen carbonate and potassium hydrogen carbonate. Also preferred are ammonium carbonate, and ammonium hydrogen carbonate. The radical scavenger is a species that can react with a carbonate radical to convert the carbonate radical by a series of fast reactions to a less reactive species. Preferably, when the radical scavenger comprises an N atom, it has a pKa > 7 to prevent the protonation of the nitrogen. Preferred radical scavengers may be selected from the classes of alkanolamines, amino sugars, amino acids and mixtures thereof, and may include, but are not limited to: monoethanolamine, 3-amino-l -propanol, 4-amino-l- butanol,5-amino-l-pentanol, l-amino-2-propanol, l-amino-2-butanol, l-amino-2- pentanol, l-amino-3-pentanol, l-amino-4-pentanol, 3-amino-2-methylpropan-l-ol, 1- amino-2-methylpropan-2-ol, 3-aminopropane-l,2-diol, glucosamine, N- acetylglucosamine, glycine, arginine, lysine, proline, glutamine, histidine, serine, tryptophan and potassium, sodium and ammonium salts of the above and mixtures thereof. Other preferred radical scavenger compounds include benzylamine, glutamic acid, imidazole, di-tert-butylhydroxytoluene, hydroquinone, catechol and mixtures thereof.
III. Methods of Manufacture The compounds of this invention may be obtained using conventional methods. A general description of how to make the compounds is provided above and specific examples are provided below. The compositions of this invention may also be obtained using conventional methods. The keratin dyeing compositions may be formed as solutions, preferably as aqueous or aqueous-alcohol solutions. The hair dye product compositions may preferably be formed as thick liquids, creams, gels, or emulsions whose composition is a mixture of the dye compound and other dye ingredients with conventional cosmetic additive ingredients suitable for the particular preparation.
IV. Methods of Use The inventive keratin dyeing compositions may be used by admixing them with a suitable oxidant, which reacts with the oxidative dye precursors to develop the hair dye product composition. The oxidant is usually provided in an aqueous composition, which normally is provided as a separate component of the finished keratin dyeing product system and present in a separate container. Upon mixing the keratin dyeing composition, the adjuvants are provided in the hair dye composition as it is applied to the hair to achieve desired product attributes, e.g., pH, viscosity, rheology, etc. The keratin dyeing composition, as it is applied to the hair, can be weakly acidic, neutral or alkaline according to their composition, typically having a pH from 6 to 11, preferably from 7 to 10, more preferably from 8 to 10. The pH of the developer composition is typically acidic, and generally the pH is from 2.5 to 6.5, preferably from 3 to 5. The pH of the hair compositions may be adjusted using a pH modifier as mentioned above. In order to use the keratin dyeing composition, the above-described compositions are mixed immediately prior to use and a sufficient amount of the mixture is applied to the hair, according to the hair abundance, generally from 60 to 200 grams. Upon such preparation the hair dye composition is applied to the hair to be dyed and remains in contact with the hair for an amount of time effective to dye the hair. Typically, the hair dye composition is allowed to act on the hair for 2 to 60, preferably 15 to 45, more preferably, 30 minutes, at a temperature ranging from 15° to 50°C. Thereafter, the hair is rinsed with water, to remove the hair dye composition and dried. If necessary, the hair is washed with a shampoo and rinsed, e.g., with water or a weakly acidic solution, such as a citric acid or tartaric acid solution, and dried. Optionally, a separate conditioning product may also be provided. Together, components of the keratin dyeing composition form a system for dyeing hair. This system may be provided as a kit comprising in a single package separate containers of the keratin dyeing composition components or other hair treatment product, and instructions for use. Examples The following are non-limiting examples of the compositions of the present invention. The examples are given solely for the puφose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention, which would be recognized by one of ordinary skill in the art. In the examples, all concentrations are listed as weight percent, unless otherwise specified. The following compositions can be used for dyeing hair. Mix the dyeing composition with an equal weight of a 20-volume hydrogen peroxide solution (6% by weight). Apply the resulting mixture to the hair and permit it to remain in contact with the hair for 30 minutes. Shampoo dyed hair and rinse with water and dry. Common base (CB) for dyeing
While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention. All documents cited in the Background, Summary of the Invention, and Detailed Description of the Invention are, in relevant part, incoφorated herein by reference; the citation of any document is not to be construed as an admission that it is prior art with respect to the present invention.

Claims

WHAT IS CLAIMED IS:
1. A keratin dyeing composition comprising: (A) a medium suitable for dyeing; and (B) one or more bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms relating to the following compounds:
wherein Y and Z are independently selected from the group consisting of NA1, S and O; wherein R1, R2, R3, and R4 are the same or different and are selected from the group consisting of: (a) C-linked monovalent substituents selected from the group consisting of: (i) substituted or unsubstituted, straight or branched, alkyl, mono- or poly- unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefϊnic systems, (ii) substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems, and (iii) substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems; wherein said systems of (i), (ii) and (iii) comprise from 1 to 10 carbon atoms and from 0 to 5 heteroatoms selected from the group consisting of O, S, N, P, and Si; (b) S-linked monovalent substituents selected from the group consisting of SA1, S02A', SO3A', SSA1, SOA1, SO2NAΑ2, SNA'A2, and SONA'A2; (c) O-linked monovalent substituents selected from the group consisting of OA1, and ONA'A2; (d) N-linked monovalent substituents selected from the group consisting of NA'A2, (NA'A^^NA'OA2, NA'SA2, NO2, N=NA\ N=NOA', NA'CN, and NA'NA2A3; (e) monovalent substituents selected from the group consisting of COOA1, CONA'2, CONA'COA2, C(=NA1)NA1A2, CN, and X; (f) fluoroalkyl monovalent substituents selected from the group consisting of mono-, poly-, and per-fluoro alkyl systems comprising from 1 to 12 carbon atoms and from 0 to 4 heteroatoms; and (g) hydrogen; wherein A1, A2, and A3 are monovalent and are independently selected from the group consisting of: H; substituted or unsubstituted, straight or branched, alkyl, mono- or poly- unsaturated alkyl, heteroalkyl, aliphatic, heteroaliphatic, or heteroolefinic systems; substituted or unsubstituted, mono- or poly-cyclic aliphatic, aryl, or heterocyclic systems; and substituted or unsubstituted, mono-, poly-, or per-fluoro alkyl systems, or A1 and A2 together with nitrogen atom to which they are bound form a ring; wherein said systems comprise from 1 to 10 carbon atoms and from 0 to 5 heteroatoms selected from the group consisting of O, S, N, P, and Si; and wherein X is a halogen selected from the group consisting of F, CI, Br, and I.
2. The composition of claim 1 wherein said R1, R2, R3, and R4 are independently selected from the group consisting of a hydrogen atom; a halogen atom; an amino substituent, a hydroxyl substituent; a cyano substituent; a Cj-C4 alkyl substituent; a trifluoromethyl substituent; an alkylamino substituent; a hydroxyalkylamino substituent; an acetylamido substituent; a carboxyl substituent or its esters; an alkoxy substituent; an alkoxyalkyl substituent; a carbamoyl substituent; an alkylcarbamoylsubstituent; a hydroxyalkylcarbamoyl substituent; an amido substituent; an alkylamido substituent; an alkylcarbonyl substituent; an alkoxycarbonyl substituent; an aryloxy substituent; an acyloxy substituent; an alkylthio substituent; an arylthio substituent; a heteroarylthio substituent; a heteroaryloxy substituent; a thiocyano substituent; a 3-, 4-, 5-, 6-, or 7- membered heterocycle having at least one nitrogen, oxygen or sulfur atom; an aryl substituent which is optionally substituted; a sulfonyl substituent; a sulfmyl substituent; a phosphonyl substituent; a sulfamoyl substituent; a siloxy substituent; an acyloxy substituent; a carbamoyloxy substituent; a sulphonamide substituent; an imide substituent; a ureido substituent; a sulfamoylamino substituent; an alkoxycarbonylamino substituent; an aryloxycarbonylamino substituent; an aryloxycarbonyl substituent; and a benzenesulfonamido substituent.
3. The composition according to claim 1 or 2 wherein said bicyclic fused 5-5 heteroaromatic keratin dyeing compound has two heteroatoms, preferably said bicyclic fused 5-5 heteroaromatic keratin dyeing compound is selected from the group consisting of Pyrrolopyrroles, Furopyrroles, Thienopyrroles, Furofurans, Thienofϊirans, Thienothiophenes, and substitutions thereof.
4. The composition according to claim 1 or 2 wherein said bicyclic fused 5-5 heteroaromatic keratin dyeing compound has three heteroatoms, preferably said bicyclic fused 5-5 heteroaromatic keratin dyeing compound is selected from the group consisting of furooxazoles, pyrrolooxazoles, thienooxazoles, furoimidazoles, pyrroloimidazoles, thienoimidazoles, furothiazoles, pyrrolothiazoles, thienothiazoles, furooxazoles, and substitutions thereof.
5. The composition according to any one of the preceding claims further comprising at least one fϊve-membered ring developer selected from the group consisting of thiophenes, pyrroles, furans, pyrazoles, imidazoles, thiazoles, oxazoles, isothiazoles, and isoxazoles, preferably pyrazoles.
6. The composition according to any one of the preceding claims wherein said bicyclic fused 5-5 heteroaromatic keratin dyeing compound contains a nucleofugic leaving group selected from the group consisting of chlorine, cyano, alkoxy, phenoxy, methylsulfonyoxy, pyridine, and pyridazone.
7. The composition according to any one of the preceding claims further comprising at least one additional component selected from the group consisting of auxiliary developers, auxiliary couplers, direct dyes, oxidizing agents, thickeners, chelants, pH modifiers, buffering agents, and carbonate ion source and radical scavenger systems.
8. A method of dyeing hair comprising the steps of (a) applying the composition according to any one of the preceding claims; and (b) rinsing hair.
9. A kit comprising (a) the composition according to any one of claims 1 to 7; (b) an oxidizing agent; and (c) auxiliary couplers and/or auxiliary developers.
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DE602005011404D1 (en) 2009-01-15
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ATE415939T1 (en) 2008-12-15
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