EP1713798A4 - TAXANES SUBSTITUTED BY A C10 CYCLOPENTYL ESTER - Google Patents

TAXANES SUBSTITUTED BY A C10 CYCLOPENTYL ESTER

Info

Publication number
EP1713798A4
EP1713798A4 EP05713407A EP05713407A EP1713798A4 EP 1713798 A4 EP1713798 A4 EP 1713798A4 EP 05713407 A EP05713407 A EP 05713407A EP 05713407 A EP05713407 A EP 05713407A EP 1713798 A4 EP1713798 A4 EP 1713798A4
Authority
EP
European Patent Office
Prior art keywords
taxanes
substituted
cyclopentyl ester
cyclopentyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05713407A
Other languages
German (de)
French (fr)
Other versions
EP1713798A2 (en
EP1713798B1 (en
Inventor
Robert A Holton
Phong Vu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University Research Foundation Inc
Original Assignee
Florida State University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University Research Foundation Inc filed Critical Florida State University Research Foundation Inc
Publication of EP1713798A2 publication Critical patent/EP1713798A2/en
Publication of EP1713798A4 publication Critical patent/EP1713798A4/en
Application granted granted Critical
Publication of EP1713798B1 publication Critical patent/EP1713798B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
EP05713407A 2004-02-13 2005-02-14 C10 cyclopentyl ester substituted taxanes Expired - Lifetime EP1713798B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54475504P 2004-02-13 2004-02-13
US61350304P 2004-09-27 2004-09-27
PCT/US2005/004442 WO2005079319A2 (en) 2004-02-13 2005-02-14 C10 cyclopentyl ester substituted taxanes

Publications (3)

Publication Number Publication Date
EP1713798A2 EP1713798A2 (en) 2006-10-25
EP1713798A4 true EP1713798A4 (en) 2007-12-05
EP1713798B1 EP1713798B1 (en) 2010-11-03

Family

ID=34890477

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05713407A Expired - Lifetime EP1713798B1 (en) 2004-02-13 2005-02-14 C10 cyclopentyl ester substituted taxanes

Country Status (21)

Country Link
US (2) US7589111B2 (en)
EP (1) EP1713798B1 (en)
JP (1) JP4879757B2 (en)
KR (1) KR101169818B1 (en)
AR (1) AR047704A1 (en)
AT (1) ATE486596T1 (en)
AU (1) AU2005214065B2 (en)
BR (1) BRPI0507671A (en)
CA (1) CA2556200C (en)
CR (1) CR8554A (en)
DE (1) DE602005024518D1 (en)
EC (1) ECSP066765A (en)
HN (1) HN2005000054A (en)
IL (1) IL177372A (en)
NO (1) NO20064090L (en)
NZ (1) NZ548769A (en)
PE (1) PE20050693A1 (en)
RU (1) RU2006132741A (en)
SV (1) SV2006002010A (en)
TW (1) TWI353354B (en)
WO (1) WO2005079319A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1303077C (en) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 Preparation process for synthesized taxane
JP4833126B2 (en) * 2007-03-26 2011-12-07 Ｎｔｎ株式会社 Lubricant deterioration detection device and bearing with detection device
CN113209287B (en) * 2021-02-04 2022-07-08 中国农业科学院农业环境与可持续发展研究所 Water-in-oil type nano vaccine adjuvant, preparation method and application thereof

Citations (3)

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EP0600517A1 (en) * 1992-12-04 1994-06-08 Bristol-Myers Squibb Company 6,7-Modified paclitaxels
WO1996030356A1 (en) * 1995-03-27 1996-10-03 Rhone-Poulenc Rorer S.A. Novel taxoids, preparation thereof and pharmaceutical compositions containing same

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US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
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US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5445908A (en) 1991-10-17 1995-08-29 Matsushita Electric Industrial Co., Ltd. Alkaline dry cell
DK0552041T3 (en) 1992-01-15 2000-10-09 Squibb & Sons Inc Enzymatic methods for cleavage of enantiomeric mixtures of compounds useful as intermediates at fr
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
FR2691460B1 (en) 1992-05-21 1994-07-22 Rhone Poulenc Rorer Sa NEW TAXANE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM.
US5254580A (en) 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
FR2696461B1 (en) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa New derivatives of taxol analogs, their preparation and compositions containing them.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MX9308012A (en) 1992-12-24 1994-08-31 Bristol Myers Squibb Co PHOSPHONOOXIMETHYL ETHER OF TAXANE DERIVATIVES, SOLUBLE IN WATER AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM.
US6593482B2 (en) * 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
FR2702212B1 (en) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa New taxoids, their preparation and the pharmaceutical compositions containing them.
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (en) 1993-05-20 1996-05-29 TAX FOR ANTI-CANCER ACTIVITIES.
ES2205663T3 (en) 1993-06-11 2004-05-01 PHARMACIA & UPJOHN COMPANY ANTINEOPLASIC USE OF DELTA 6,7-TAXOLS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
WO1995004154A1 (en) 1993-07-27 1995-02-09 Nippon Steel Corporation Process for producing taxol and its analogues using microorganisms
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
DE69507702T2 (en) 1994-07-26 1999-08-26 Indena S.P.A. SEMISYNTHETIC TAXAL DERIVATIVES WITH ANTITUMOR EFFECT
US6100411A (en) 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
EP0788493A1 (en) 1994-10-28 1997-08-13 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US5719177A (en) 1994-11-04 1998-02-17 Pharmacia S.P.A. Taxane derivatives
FR2732342B1 (en) 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2732968B1 (en) 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
US5760251A (en) 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
WO1997009979A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
US5767297A (en) 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
AU724499B2 (en) 1996-05-06 2000-09-21 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
ES2151277T3 (en) 1996-05-22 2000-12-16 Protarga Inc COMPOSITIONS INCLUDING CONJUGATES OF CIS-DOCOSAHEXAENOIC ACID AND TAXOTERE.
AU710156B2 (en) 1996-07-15 1999-09-16 Kabushiki Kaisha Yakult Honsha Taxane derivatives and drugs containing the same
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
CA2206739C (en) 1997-06-03 2006-10-10 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
JPH1192468A (en) 1997-09-17 1999-04-06 Yakult Honsha Co Ltd New taxane derivatives
WO1999032473A1 (en) 1997-12-19 1999-07-01 Kabushiki Kaisha Yakult Honsha Taxane derivatives
US6156789A (en) 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
JP2003026673A (en) 1999-03-05 2003-01-29 Asahi Kasei Corp Bone formation promoter
TR200102857T1 (en) 2000-02-02 2002-06-21 Florida State University Research Foundation Inc. C7 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
JP2003522171A (en) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド C10 carbonate substituted taxanes as antitumor agents
HUP0600302A2 (en) 2000-02-02 2006-07-28 Univ Florida State Res Found C10 ester substituted taxanes as antitumor agents
KR20010111580A (en) 2000-02-02 2001-12-19 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 Taxane formulations having improved solubility
CA2367661A1 (en) 2000-02-02 2001-08-09 Robert A. Holton Taxane formulations having improved solubility
IT1319168B1 (en) 2000-03-17 2003-09-26 Indena Spa ANTI-CANCER CONDENSATION DERIVATIVES, THEIR METHOD OF PREPARATION AND FORMULATIONS CONTAINING THEM.
JP4717252B2 (en) * 2001-04-25 2011-07-06 株式会社小松製作所 Press slide drive device
CA2354471A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 ester substituted taxanes
JP2008530122A (en) 2005-02-14 2008-08-07 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド C10 cyclopropyl ester substituted taxane composition
CA2808297C (en) * 2010-08-13 2018-09-18 Roilblue Corporation Oil containment assembly and method of using same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590267A2 (en) * 1992-10-01 1994-04-06 Bristol-Myers Squibb Company Deoxy taxols
EP0600517A1 (en) * 1992-12-04 1994-06-08 Bristol-Myers Squibb Company 6,7-Modified paclitaxels
WO1996030356A1 (en) * 1995-03-27 1996-10-03 Rhone-Poulenc Rorer S.A. Novel taxoids, preparation thereof and pharmaceutical compositions containing same

Also Published As

Publication number Publication date
AU2005214065A1 (en) 2005-09-01
JP2007522236A (en) 2007-08-09
EP1713798A2 (en) 2006-10-25
ECSP066765A (en) 2006-12-29
EP1713798B1 (en) 2010-11-03
RU2006132741A (en) 2008-03-20
US7589111B2 (en) 2009-09-15
KR20060129018A (en) 2006-12-14
US8003812B2 (en) 2011-08-23
NO20064090L (en) 2006-11-10
CR8554A (en) 2008-04-25
IL177372A (en) 2011-09-27
TWI353354B (en) 2011-12-01
US20050228037A1 (en) 2005-10-13
AU2005214065B2 (en) 2009-11-12
US20100056614A1 (en) 2010-03-04
ATE486596T1 (en) 2010-11-15
BRPI0507671A (en) 2007-07-17
SV2006002010A (en) 2006-08-23
PE20050693A1 (en) 2005-09-27
HK1097534A1 (en) 2007-06-29
JP4879757B2 (en) 2012-02-22
NZ548769A (en) 2009-10-30
DE602005024518D1 (en) 2010-12-16
CA2556200C (en) 2012-06-26
IL177372A0 (en) 2006-12-10
AR047704A1 (en) 2006-02-08
WO2005079319A3 (en) 2005-11-17
AU2005214065A2 (en) 2005-09-01
TW200530209A (en) 2005-09-16
WO2005079319A2 (en) 2005-09-01
CA2556200A1 (en) 2005-09-01
KR101169818B1 (en) 2012-07-30
HN2005000054A (en) 2009-02-18

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