EP1670486A4 - Traitement d'un trouble chez un mammifere par administration d'une sucre amine et utilisations associees - Google Patents

Traitement d'un trouble chez un mammifere par administration d'une sucre amine et utilisations associees

Info

Publication number
EP1670486A4
EP1670486A4 EP04789289A EP04789289A EP1670486A4 EP 1670486 A4 EP1670486 A4 EP 1670486A4 EP 04789289 A EP04789289 A EP 04789289A EP 04789289 A EP04789289 A EP 04789289A EP 1670486 A4 EP1670486 A4 EP 1670486A4
Authority
EP
European Patent Office
Prior art keywords
adminisration
aminosugar
mammal
treatment
condition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04789289A
Other languages
German (de)
English (en)
Other versions
EP1670486A1 (fr
Inventor
Youe-Kong Shue
Franklin W Okumu
Alexander R Shikhman
Martin Lotz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Optimer Pharmaceuticals LLC
Original Assignee
Scripps Research Institute
Optimer Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute, Optimer Pharmaceuticals LLC filed Critical Scripps Research Institute
Publication of EP1670486A1 publication Critical patent/EP1670486A1/fr
Publication of EP1670486A4 publication Critical patent/EP1670486A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
EP04789289A 2003-10-01 2004-09-30 Traitement d'un trouble chez un mammifere par administration d'une sucre amine et utilisations associees Withdrawn EP1670486A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50771603P 2003-10-01 2003-10-01
PCT/US2004/032048 WO2005034961A1 (fr) 2003-10-01 2004-09-30 Traitement d'un trouble chez un mammifere par administration d'une sucre amine et utilisations associees

Publications (2)

Publication Number Publication Date
EP1670486A1 EP1670486A1 (fr) 2006-06-21
EP1670486A4 true EP1670486A4 (fr) 2009-04-01

Family

ID=34434891

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04789289A Withdrawn EP1670486A4 (fr) 2003-10-01 2004-09-30 Traitement d'un trouble chez un mammifere par administration d'une sucre amine et utilisations associees

Country Status (5)

Country Link
EP (1) EP1670486A4 (fr)
JP (1) JP2007507516A (fr)
CN (1) CN1909911A (fr)
CA (1) CA2540586A1 (fr)
WO (1) WO2005034961A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007518814A (ja) * 2004-01-20 2007-07-12 ザ・スクリップス・リサーチ・インスティテュート グリコシダーゼ阻害剤によるほ乳類での変性軟骨症の治療
MX338123B (es) * 2008-07-18 2016-04-04 Genis Hf Composicion de glucosamina y quitobiomero.
KR101098581B1 (ko) * 2009-01-09 2011-12-26 서울대학교산학협력단 Ａｂｈ 항원을 이용한 염증질환 개선용 조성물
MX347014B (es) * 2010-11-24 2017-04-07 Durect Corp Composición para administración de fármaco biodegradable.
CN102614111B (zh) * 2012-04-05 2013-11-06 苏州豫源生物医药有限公司 氨基葡萄糖的凝胶剂及其制备方法
CN105884720A (zh) * 2016-04-23 2016-08-24 陈斌 一种盐酸丁螺环酮的药物组合物及其医药用途
WO2020104833A1 (fr) * 2018-11-19 2020-05-28 4P-Pharma Composition et procédés pour réguler la prolifération de chondrocytes et augmenter la production de matrice cartilagineuse
CN112169713A (zh) * 2020-09-09 2021-01-05 江南大学 一种n-烷基乳糖胺表面活性剂小分子醇凝胶及其制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0379753A1 (fr) * 1989-01-26 1990-08-01 Steigerwald Arzneimittelwerk Gmbh Préparations de N-acétylglucosamine pour utilisation buccale
WO1997021434A1 (fr) * 1995-12-11 1997-06-19 Inholtra, Inc. Regime alimentaire a base de complements nutritionnels permettant de soulager les symptomes de l'arthrite
WO1998025631A1 (fr) * 1996-12-13 1998-06-18 Lescarden, Inc. Traitement de l'arthrose par administration de poly-n-acetyl-d-glucosamine
US6346519B1 (en) * 1998-09-09 2002-02-12 Advanced Medical Instruments Method and composition for treating arthritis
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
WO2002078445A1 (fr) * 2001-03-29 2002-10-10 The Scripps Research Institute Formulations comprenant des ingredients actifs pieges et utilisations de ces formulations
WO2003026677A1 (fr) * 2001-09-26 2003-04-03 Primex Ehf. Composition pharmaceutique comprenant des chito-oligomeres

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM666894A0 (en) * 1994-07-07 1994-07-28 University Of Melbourne, The Diagnostic methods and compositions
US5840715A (en) * 1995-12-11 1998-11-24 Inholtra Investment Holdings & Trading, N.V. Dietary regimen of nutritional supplements for relief of symptoms of arthritis
US6514983B1 (en) * 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6514522B2 (en) * 1998-04-08 2003-02-04 Chondros, Inc. Polymer constructs
JP2002515488A (ja) * 1998-05-15 2002-05-28 ギルフォード ファーマシューティカルズ インコーポレイテッド カルボキサミド化合物、組成物、及びｐａｒｐ活性の抑制方法
US6506785B2 (en) * 1998-05-22 2003-01-14 Pfizer, Inc. Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives
US6656925B2 (en) * 1998-09-09 2003-12-02 Advanced Medical Instruments Composition and method of treating arthritis
US6662805B2 (en) * 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
MXPA01011542A (es) * 2001-11-13 2003-05-22 Alcon Inc Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel.
EP1448166A1 (fr) * 2001-11-30 2004-08-25 Pfizer Inc. Compositions polymeres a liberation controlee de composes stimulant la formation osseuse
JP2003225093A (ja) * 2001-11-30 2003-08-12 Sumitomo Pharmaceut Co Ltd 軟骨障害マーカー及びその利用

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0379753A1 (fr) * 1989-01-26 1990-08-01 Steigerwald Arzneimittelwerk Gmbh Préparations de N-acétylglucosamine pour utilisation buccale
WO1997021434A1 (fr) * 1995-12-11 1997-06-19 Inholtra, Inc. Regime alimentaire a base de complements nutritionnels permettant de soulager les symptomes de l'arthrite
WO1998025631A1 (fr) * 1996-12-13 1998-06-18 Lescarden, Inc. Traitement de l'arthrose par administration de poly-n-acetyl-d-glucosamine
US6117851A (en) * 1996-12-13 2000-09-12 Lescarden Inc. Treatment of osteoarthritis by administering poly-N-acetyl-D-glucosamine
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
US6346519B1 (en) * 1998-09-09 2002-02-12 Advanced Medical Instruments Method and composition for treating arthritis
WO2002078445A1 (fr) * 2001-03-29 2002-10-10 The Scripps Research Institute Formulations comprenant des ingredients actifs pieges et utilisations de ces formulations
WO2003026677A1 (fr) * 2001-09-26 2003-04-03 Primex Ehf. Composition pharmaceutique comprenant des chito-oligomeres

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GREILING H ET AL: "DIE HEMMUNG LYSOSOMALER ENZYME DURCH EIN GLYKOSAMINOGLYKANPOLYSULFAT ZUR THERAPIE CHRONISCHER GELENKERKRANKUNGEN MIT ANTIDEGENERATIV WIRKSAMEN VERDINGUNGEN; EIN BEITRAG ZUR BIOCHEMIE", ARZNEIMITTEL FORSCHUNG. DRUG RESEARCH, ECV EDITIO CANTOR VERLAG, AULENDORF, DE, vol. 23, no. 4, 1 January 1973 (1973-01-01), pages 593 - 597, XP000990352, ISSN: 0004-4172 *
LIU J ET AL: "Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 8, no. 7, 1 January 2001 (2001-01-01), pages 701 - 711, XP002444424, ISSN: 1074-5521 *
See also references of WO2005034961A1 *
SHIKHMAN A R ET AL: "N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes", JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 166, no. 8, 15 April 2001 (2001-04-15), pages 5155 - 5160, XP002505181, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
CN1909911A (zh) 2007-02-07
WO2005034961A1 (fr) 2005-04-21
JP2007507516A (ja) 2007-03-29
CA2540586A1 (fr) 2005-04-21
EP1670486A1 (fr) 2006-06-21

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060421

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: OPTIMER PHARMACEUTICALS

Owner name: THE SCRIPPS RESEARCH INSTITUTE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SHUE, YOUE-KONG

Inventor name: LOTZ, MARTIN

Inventor name: OKUMU, FRANKLIN, W.

Inventor name: SHIKHMAN, ALEXANDER, R.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE SCRIPPS RESEARCH INSTITUTE

Owner name: OPTIMER PHARMACEUTICALS, INC.

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20090304

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 19/02 20060101ALI20090226BHEP

Ipc: A61K 31/70 20060101AFI20050425BHEP

17Q First examination report despatched

Effective date: 20091013

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20101122