EP1605893A4 - Trans-membrane-antibody induced inhibition of apoptosis - Google Patents

Trans-membrane-antibody induced inhibition of apoptosis

Info

Publication number
EP1605893A4
EP1605893A4 EP04718110A EP04718110A EP1605893A4 EP 1605893 A4 EP1605893 A4 EP 1605893A4 EP 04718110 A EP04718110 A EP 04718110A EP 04718110 A EP04718110 A EP 04718110A EP 1605893 A4 EP1605893 A4 EP 1605893A4
Authority
EP
European Patent Office
Prior art keywords
apoptosis
trans
membrane
induced inhibition
antibody induced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04718110A
Other languages
German (de)
French (fr)
Other versions
EP1605893A2 (en
Inventor
Heinz Kohler
Sybille Muller
Thomas L Brown
Yunfeng Zhao
Alton C Morgan Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innexus Biotechnology Inc Canada
Immpheron Inc
Original Assignee
Innexus Biotechnology Inc Canada
Immpheron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innexus Biotechnology Inc Canada, Immpheron Inc filed Critical Innexus Biotechnology Inc Canada
Publication of EP1605893A2 publication Critical patent/EP1605893A2/en
Publication of EP1605893A4 publication Critical patent/EP1605893A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
EP04718110A 2003-03-05 2004-03-05 Trans-membrane-antibody induced inhibition of apoptosis Withdrawn EP1605893A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45198003P 2003-03-05 2003-03-05
US451980P 2003-03-05
PCT/US2004/006911 WO2004078146A2 (en) 2003-03-05 2004-03-05 Trans-membrane-antibody induced inhibition of apoptosis

Publications (2)

Publication Number Publication Date
EP1605893A2 EP1605893A2 (en) 2005-12-21
EP1605893A4 true EP1605893A4 (en) 2008-08-13

Family

ID=32962675

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04718110A Withdrawn EP1605893A4 (en) 2003-03-05 2004-03-05 Trans-membrane-antibody induced inhibition of apoptosis

Country Status (5)

Country Link
EP (1) EP1605893A4 (en)
JP (1) JP2006522122A (en)
KR (1) KR20060006775A (en)
CA (1) CA2518119A1 (en)
WO (1) WO2004078146A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004049479A1 (en) * 2004-10-11 2006-04-13 Scil Proteins Gmbh Protein conjugates for use in therapy, diagnosis and chromatography
US8361462B2 (en) 2005-09-01 2013-01-29 National Research Council Of Canada Anti-apoptotic protein antibodies
IT1392238B1 (en) * 2008-12-02 2012-02-22 Fond Santa Lucia USE OF CASPASI-3 FOR ALZHEIMER DISEASE
WO2010119249A1 (en) * 2009-04-14 2010-10-21 Trojan Technologies Ltd. Therapeutic antennapedia-antibody molecules and methods of use thereof
WO2014144542A2 (en) * 2013-03-15 2014-09-18 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
US10456475B2 (en) 2015-02-03 2019-10-29 Kennsaw State University Research and Service Foundation, Inc. Cell penetrating protein adaptor molecules and their application in research and medicine
US10435446B2 (en) 2015-06-03 2019-10-08 Kennesaw State University Research and Service Foundation Inc. Cell penetrating protein adaptor molecules and their application in research and medicine
MA44334A (en) 2015-10-29 2018-09-05 Novartis Ag ANTIBODY CONJUGATES INCLUDING A TOLL-TYPE RECEPTOR AGONIST
EP3411387A4 (en) 2016-02-03 2019-12-04 Kennesaw State University Research And Services Foundation Inc. Signal molecules as cell penetration agents

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060866A1 (en) * 2000-02-15 2001-08-23 The Secretary Of State For Defence Anti-viral conjugate comprising a factor allowing the translocation of a protein across a cell membrane and comprising a single-chain antibody fragment directed against a viral protein
US6316003B1 (en) * 1989-12-21 2001-11-13 Whitehead Institute For Biomedical Research Tat-derived transport polypeptides
US20020143142A1 (en) * 1998-03-31 2002-10-03 Vanderbilt University Sequence and method for genetic engineering of proteins with cell membrane translocating activity
EP1488804A1 (en) * 2002-03-22 2004-12-22 Bipha Corporation Immunoglobulin/hydrophilic peptide complexes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2813630B2 (en) * 1987-02-20 1998-10-22 ジェネンテク，インコーポレイテッド Human immunodeficiency virus envelope polypeptide and its antibody
US5242824A (en) * 1988-12-22 1993-09-07 Oncogen Monoclonal antibody to human carcinomas
DE60043784D1 (en) * 1999-12-06 2010-03-18 Agensys Inc SERPENTINETRANSMEMBRANE RECEPTORS EXPRESSED IN HUMAN PROSTATE CANCER AND ITS USES
CA2421172A1 (en) * 2000-09-08 2002-03-14 Merck Frosst Canada & Co. Gamma-ketoacid dipeptides as inhibitors of caspase-3
JP2002355077A (en) * 2001-02-23 2002-12-10 Takeda Chem Ind Ltd Caspase 3 inhibitor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316003B1 (en) * 1989-12-21 2001-11-13 Whitehead Institute For Biomedical Research Tat-derived transport polypeptides
US20020143142A1 (en) * 1998-03-31 2002-10-03 Vanderbilt University Sequence and method for genetic engineering of proteins with cell membrane translocating activity
WO2001060866A1 (en) * 2000-02-15 2001-08-23 The Secretary Of State For Defence Anti-viral conjugate comprising a factor allowing the translocation of a protein across a cell membrane and comprising a single-chain antibody fragment directed against a viral protein
EP1488804A1 (en) * 2002-03-22 2004-12-22 Bipha Corporation Immunoglobulin/hydrophilic peptide complexes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MULLER SYBILLE ET AL: "TransMabs: cell-penetrating antibodies, the next generation", EXPERT OPINION ON BIOLOGICAL THERAPY, ASHLEY, LONDON, GB, vol. 5, no. 2, 1 February 2005 (2005-02-01), pages 237 - 241, XP008093137, ISSN: 1471-2598 *
ROJAS M ET AL: "GENETIC ENGINEERING OF PROTEINS WITH CELL MEMBRANE PERMEABILITY", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 16, no. 4, 1 April 1998 (1998-04-01), pages 370 - 375, XP001118371, ISSN: 1087-0156 *
STEIN S ET AL: "A disulfide conjugate between anti-tetanus antibodies and HIV (37-72)Tat neutralizes tetanus toxin inside chromaffin cells", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 458, no. 3, 24 September 1999 (1999-09-24), pages 383 - 386, XP004260296, ISSN: 0014-5793 *
ZHAO Y ET AL: "MTS-conjugated-antiactive caspase 3 antibodies inhibit actinomycin D-induced apoptosis.", APOPTOSIS : AN INTERNATIONAL JOURNAL ON PROGRAMMED CELL DEATH DEC 2003, vol. 8, no. 6, December 2003 (2003-12-01), pages 631 - 637, XP002485667, ISSN: 1360-8185 *

Also Published As

Publication number Publication date
CA2518119A1 (en) 2004-09-16
WO2004078146A3 (en) 2006-01-05
KR20060006775A (en) 2006-01-19
JP2006522122A (en) 2006-09-28
WO2004078146A2 (en) 2004-09-16
EP1605893A2 (en) 2005-12-21

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Inventor name: MORGAN, ALTON C., JR.,INNEXUS BIOTECHNOLOGY, INC.

Inventor name: ZHAO, YUNFENG,C/O LSU HEALTH SCIENCE CENTER

Inventor name: BROWN, THOMAS, L.

Inventor name: MULLER, SYBILLE

Inventor name: KOHLER, HEINZ

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