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Vaginal spray nozzle

Info

Publication number
EP1600185A1
EP1600185A1 EP20050011210 EP05011210A EP1600185A1 EP 1600185 A1 EP1600185 A1 EP 1600185A1 EP 20050011210 EP20050011210 EP 20050011210 EP 05011210 A EP05011210 A EP 05011210A EP 1600185 A1 EP1600185 A1 EP 1600185A1
Authority
EP
Grant status
Application
Patent type
Prior art keywords
vaginal
part
inside
cylindrical
spray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP20050011210
Other languages
German (de)
French (fr)
Inventor
Lapo Landi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Progine Farmaceutici Srl
Original Assignee
PROGINE FARMACEUTICI SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators
    • A61M3/02Enemata; Irrigators
    • A61M3/0233Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0254Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators
    • A61M3/02Enemata; Irrigators
    • A61M3/0279Cannula; Nozzles; Tips; their connection means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus
    • B05B11/30Single-unit, i.e. unitary, hand-held apparatus comprising a container and a discharge nozzle attached thereto, in which flow of liquid or other fluent material is produced by the muscular energy of the operator at the moment of use or by an equivalent manipulator independent from the apparatus the flow being effected by a pump
    • B05B11/3001Piston pumps
    • B05B11/3023Piston pumps having an outlet valve opened by deformation or displacement of the piston relative to its actuating stem
    • B05B11/3025Piston pumps having an outlet valve opened by deformation or displacement of the piston relative to its actuating stem a spring urging the outlet valve in its closed position

Abstract

A container (1) with an upper threaded part (2) is provided to which is screwed a suction pump (3) with inside thread (4). Said pump with a cylindrical outside body (5) and with a lower pipe (6) to suck the liquid contained in the container (1). Said pipe (6) is fitted into a valve (7) having in the upper part a push-rod (11) with piston (12) in contact with the main spring (13) and having in its inside a stem (14) that goes to fit into the cylindrical concavity (16) with a hole (17) communicates with a cannula (18) having on its end a hole (20) and placed onto the outside part of a cylindrical body (19).

Description

  • [0001]
    Within the gynecology has big importance the getting in of pharmaceutical substances and/or detergents inside the vagina. The distribution of said substances is of fundamental importance both for the absorption to the vaginal tissues than for the permanence of the active factor of the medicinal substance in the parts with inflammations or lesions. In the art the medical substances and/or detergents are put inside the vagina by means of lavages, foams or ovules. The vaginal lavages consists of liquids inside containers with cannulas. Squeezing the container walls the liquid runs off. Said liquid goes out to the cannula to flow inside the vagina and then it flows outside. Unfortunately this kind of use has the risk of contamination upward. Infact, said liquid, running upward, brings a diffusion of bacteria, cells or others microorganisms to the uterus and to the cervix uteri. Moreover, this application way brings the active factors of the medicament in contact with the inflamed or ill tissue for short time and it is little persistent. Other method provides the application of vaginal foams. These are spray foams with compressed gas into a bombs from which get out liquid or foam. Unfortunately also this method has sides that limit its uses. Infact, the gas used like propellant is also it an irritation cause. While the methods that use ecological foams without propellant gas have only the deterging function. In these cases, infact, the foam gets out and, turning into water solution, it percolates to the part in which was put so being, in this way, troublesome. Moreover, this kind of use has a short contact time onto the irritated or infect part. Other kind of application of the medicaments is actuated by means of vaginal ovules. These ovules are introduced in the vagina with a finger, but so introducing also bacteria. The vaginal ovules have a longer time of application, such as they remain in position for some hours, but, being formed of excipients like semisynthetic triglycerides and thickenings or similar substances, they leaves residuals so to have the necessity to do vaginal lavages after that said ovules are dissolved. The used excipients and thickenings have, moreover, the problem to often create allergies to the vaginal walls. Moreover the ovule, such as it is very concentrated in the active factor, determines heartburns in the point where it is positioned. Similar problems are given to the creams or to the vaginal gels, sometimes used in single-dose to be applied with tubes and syringes, because they have creams and excipients that leave inside fat residuals. The invented means, different to the previous art, consists of a spray nozzle that permits to reach the critical points of the vagina without manual contact, actuating a nebulization of the medical and/or deterging substance. In this way a uniform distribution to the vaginal walls is obtained helping to the presence in position of gel with low viscosity or liquids in solution put in circulation to the nozzle spray. In this way good adherence characteristics are obtained with consequent longer contact time of the lavages or of the foams with the parts to be treated. The getting in is, then, actuated with a jet having the least pressure so to not go upward the bacteria or the vaginal secretion residuals so avoiding to help vaginal erosions. The invented means, infact, reaches directly the cervix uteri acting onto the parts interested to lesions or inflammations. Moreover, different to the ovule that concentrates the substance effect in one point, the invented means permits to distribute the active substance long all the vaginal duct, starting to the top and in succession descending, with an uniform and persistent distribution onto the vaginal walls. The invented spray nozzle consists of a container 1 with the upper part having a thread 2. In said container 1 is threaded, through the upper thread 2, a suction pump 3. Said pump has an inside thread 4, complementary to the previous one, and it has an outside cylindrical body 5. The suction pump 3 has in the lower part a pipe 6 that goes to suck the fluid inside the container 1. Said pipe 6 is then fitted in the cylindrical body of a valve 7. Inside said valve is put a sphere 8 pressing against the inside walls of the valve by means of a spring 9 and of a holding means 10. In the upper part and in the middle of the spring 9 is present a push-rod 11 with, in standstill to in the upper part, a piston 12. Said piston is itself in contact with the main spring 13. Inside said piston, coaxially, is provided a stem 14 inside which runs the upper cylindrical part of the push-rod 11.To contain the valve 7 there is a flange 15 fitted in onto the inside part of the cylindrical body 5. The jutted out part of the stem 14 is fitted into the cylindrical concavity 16 with a hole 17 communicates with the cannula 18 placed onto the outside part of the cylindrical body 19. Said cannula 18 has a length so to can easy reach the cervix uteri. The cannula 18 has on its end a hole 20 from where the contained liquid is nebulized. The end of said cannula is in ogive shape. Squeezing in the upper part the cylindrical body 19, and consequently the stem 14, the substance present inside the container 1 is nebulized. The invented means is, moreover, equipped of changing parts to be used only one time to not bring, through the cannula 18, again the bacteria into the vagina. For this reason the upper part fitted in onto the stem 14 is to be changed after each use. Said part, i.e. the upper cylindrical body 19 and the cannula 18, in non-toxic plastic material, is the part that is introduced into the vagina and so can be subjected to bacteria , virus, cells and other formations. Moreover, being the nebulizaton with at least pressure but sufficient to permit it , does not bring into the vagina neither what previous cited nor neoplastic cells. The invented means, moreover, permits to increase the contact time of the active medical substances and to have an uniform distribution long all the vaginal duct such as, moving the spray nozzle during the use, there is an uniform and persistent distribution onto the walls. The invented means is illustrated in a merely indicative and not limiting way in the drawings of sheets 1, 2 and 3. In sheet 1 figure 1 is perspective view of the vaginal spray nozzle with the part to be changed in the subsequent use. In sheet 2 the figure 2 is exploded view to the nozzle. In sheet 3 figure 2 is view of the use with the medical substance puts into the vagina by means of the invented spray nozzle.

Claims (7)

  1. Vaginal spray nozzle characterized in that to consist of a container (1) with an upper threaded part (2) to which is screwed a suction pump (3) with inside thread (4), with cylindrical outside body (5) and with a lower pipe (6) to suck the liquid contained in the container (1); and with said pipe (6) fitted into a valve (7) having in the upper part a push-rod (11) with piston (12) in contact with the main spring (13) and having in its inside a stem (14) that goes to fit into the cylindrical concavity (16) with a hole (17) communicates with a cannula (18) having on its end a hole (20) and placed onto the outside part of a cylindrical body (19).
  2. Vaginal spray nozzle, as per claim 1, characterized in that the cannula (18) has a length so to easy reach the cervix uteri.
  3. Vaginal spray nozzle, as per claim 1, characterized in that the hole (20) at the end of the cannula (18) permits to nebulization of the liquid present in the container (1).
  4. Vaginal spray nozzle, as per claim 1, characterized in that squeezing in the upper part the cylindrical body (19) and consequently the stem (14), the substance present inside the container (1) is nebulized.
  5. Vaginal spray nozzle, as per claim 1, characterized in that the upper cylindrical body (19) and the cannula (18), in non-toxic plastic material, are to be changed after each use to avoid infections.
  6. Vaginal spray nozzle, as per claim 1, characterized in that it permits to increase the contact time of the medical substances and to have an uniform distribution long all the vaginal duct.
  7. Vaginal spray nozzle, as per claim 1, characterized in that being the nebulization with least pressure, but sufficient to permit it, does not bring into the vagina the bacteria, virus or other.
EP20050011210 2004-05-28 2005-05-24 Vaginal spray nozzle Ceased EP1600185A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITBO20040338 2004-05-28
ITBO20040338 2004-05-28

Publications (1)

Publication Number Publication Date
EP1600185A1 true true EP1600185A1 (en) 2005-11-30

Family

ID=34981840

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20050011210 Ceased EP1600185A1 (en) 2004-05-28 2005-05-24 Vaginal spray nozzle

Country Status (1)

Country Link
EP (1) EP1600185A1 (en)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008117320A1 (en) * 2007-03-28 2008-10-02 Bormioli Rocco & Figlio S.P.A. An applicator assembly for hygienic-medical irrigation, in particular for vaginal irrigation
US8114385B2 (en) 2003-08-04 2012-02-14 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US8119106B2 (en) 2003-04-28 2012-02-21 Foamix Ltd Foamable iodine compositions
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US8343945B2 (en) 2007-12-07 2013-01-01 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8362091B2 (en) 2003-08-04 2013-01-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
US8435498B2 (en) 2002-10-25 2013-05-07 Foamix Ltd. Penetrating pharmaceutical foam
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
US8618081B2 (en) 2009-10-02 2013-12-31 Foamix Ltd. Compositions, gels and foams with rheology modulators and uses thereof
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US8722021B2 (en) 2002-10-25 2014-05-13 Foamix Ltd. Foamable carriers
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8795635B2 (en) 2006-11-14 2014-08-05 Foamix Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US9622947B2 (en) 2002-10-25 2017-04-18 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US9884017B2 (en) 2017-06-30 2018-02-06 Foamix Pharmaceuticals Ltd. Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3108590A (en) 1962-05-21 1963-10-29 Esta Medical Lab Inc Combination aerosol, container and applicator
GB1507116A (en) 1975-07-21 1978-04-12 Spatz Corp Fluid dispensing devices
US4157093A (en) 1978-02-09 1979-06-05 Brodsky Ralph H Hygiene system
US5857991A (en) 1995-08-10 1999-01-12 Grothoff; Hans Device for applying medication fluid on mucus membrane in body cavities
US6354519B1 (en) 1999-11-16 2002-03-12 Asahi Kogaku Kogyo Kabushiki Kaisha Spray device for an endoscope

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3108590A (en) 1962-05-21 1963-10-29 Esta Medical Lab Inc Combination aerosol, container and applicator
GB1507116A (en) 1975-07-21 1978-04-12 Spatz Corp Fluid dispensing devices
US4157093A (en) 1978-02-09 1979-06-05 Brodsky Ralph H Hygiene system
US5857991A (en) 1995-08-10 1999-01-12 Grothoff; Hans Device for applying medication fluid on mucus membrane in body cavities
US6354519B1 (en) 1999-11-16 2002-03-12 Asahi Kogaku Kogyo Kabushiki Kaisha Spray device for an endoscope

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US8741265B2 (en) 2002-10-25 2014-06-03 Foamix Ltd. Penetrating pharmaceutical foam
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US9713643B2 (en) 2002-10-25 2017-07-25 Foamix Pharmaceuticals Ltd. Foamable carriers
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8435498B2 (en) 2002-10-25 2013-05-07 Foamix Ltd. Penetrating pharmaceutical foam
US9492412B2 (en) 2002-10-25 2016-11-15 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US8840869B2 (en) 2002-10-25 2014-09-23 Foamix Ltd. Body cavity foams
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US9622947B2 (en) 2002-10-25 2017-04-18 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US8722021B2 (en) 2002-10-25 2014-05-13 Foamix Ltd. Foamable carriers
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8486375B2 (en) 2003-04-28 2013-07-16 Foamix Ltd. Foamable compositions
US8119106B2 (en) 2003-04-28 2012-02-21 Foamix Ltd Foamable iodine compositions
US9636405B2 (en) 2003-08-04 2017-05-02 Foamix Pharmaceuticals Ltd. Foamable vehicle and pharmaceutical compositions thereof
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8703105B2 (en) 2003-08-04 2014-04-22 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8362091B2 (en) 2003-08-04 2013-01-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
US9101662B2 (en) 2003-08-04 2015-08-11 Foamix Pharmaceuticals Ltd. Compositions with modulating agents
US8114385B2 (en) 2003-08-04 2012-02-14 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US9050253B2 (en) 2003-08-04 2015-06-09 Foamix Pharmaceuticals Ltd. Oleaginous pharmaceutical and cosmetic foam
US8518378B2 (en) 2003-08-04 2013-08-27 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8795635B2 (en) 2006-11-14 2014-08-05 Foamix Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US9682021B2 (en) 2006-11-14 2017-06-20 Foamix Pharmaceuticals Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
WO2008117320A1 (en) * 2007-03-28 2008-10-02 Bormioli Rocco & Figlio S.P.A. An applicator assembly for hygienic-medical irrigation, in particular for vaginal irrigation
US9662298B2 (en) 2007-08-07 2017-05-30 Foamix Pharmaceuticals Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US8343945B2 (en) 2007-12-07 2013-01-01 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US9549898B2 (en) 2007-12-07 2017-01-24 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US9795564B2 (en) 2007-12-07 2017-10-24 Foamix Pharmaceuticals Ltd. Oil-based foamable carriers and formulations
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
US9161916B2 (en) 2007-12-07 2015-10-20 Foamix Pharmaceuticals Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8900553B2 (en) 2007-12-07 2014-12-02 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US9572775B2 (en) 2009-07-29 2017-02-21 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9675700B2 (en) 2009-10-02 2017-06-13 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
US8865139B1 (en) 2009-10-02 2014-10-21 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
US8871184B2 (en) 2009-10-02 2014-10-28 Foamix Ltd. Topical tetracycline compositions
US8618081B2 (en) 2009-10-02 2013-12-31 Foamix Ltd. Compositions, gels and foams with rheology modulators and uses thereof
US8945516B2 (en) 2009-10-02 2015-02-03 Foamix Pharmaceuticals Ltd. Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US8992896B2 (en) 2009-10-02 2015-03-31 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
US9884017B2 (en) 2017-06-30 2018-02-06 Foamix Pharmaceuticals Ltd. Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof

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