EP1599494A4 - Wiederherstellung der funktion von mutanten des gonadotropin-freisetzungshormonrezeptors - Google Patents

Wiederherstellung der funktion von mutanten des gonadotropin-freisetzungshormonrezeptors

Info

Publication number
EP1599494A4
EP1599494A4 EP04705679A EP04705679A EP1599494A4 EP 1599494 A4 EP1599494 A4 EP 1599494A4 EP 04705679 A EP04705679 A EP 04705679A EP 04705679 A EP04705679 A EP 04705679A EP 1599494 A4 EP1599494 A4 EP 1599494A4
Authority
EP
European Patent Office
Prior art keywords
restoring
functions
mutant receptors
release hormone
gonadotrophin release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04705679A
Other languages
English (en)
French (fr)
Other versions
EP1599494A2 (de
Inventor
P Michael Conn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health and Science University
Original Assignee
Oregon Health and Science University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health and Science University filed Critical Oregon Health and Science University
Publication of EP1599494A2 publication Critical patent/EP1599494A2/de
Publication of EP1599494A4 publication Critical patent/EP1599494A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
EP04705679A 2003-01-29 2004-01-27 Wiederherstellung der funktion von mutanten des gonadotropin-freisetzungshormonrezeptors Withdrawn EP1599494A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44369103P 2003-01-29 2003-01-29
US443691P 2003-01-29
PCT/US2004/002290 WO2004069859A2 (en) 2003-01-29 2004-01-27 Restoring function to gonadotropin releasing hormone receptor mutants

Publications (2)

Publication Number Publication Date
EP1599494A2 EP1599494A2 (de) 2005-11-30
EP1599494A4 true EP1599494A4 (de) 2010-01-06

Family

ID=32850796

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04705679A Withdrawn EP1599494A4 (de) 2003-01-29 2004-01-27 Wiederherstellung der funktion von mutanten des gonadotropin-freisetzungshormonrezeptors

Country Status (4)

Country Link
EP (1) EP1599494A4 (de)
AU (1) AU2004208990B2 (de)
CA (1) CA2514449A1 (de)
WO (1) WO2004069859A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
AU2010254092B2 (en) * 2009-05-26 2015-11-12 Amicus Therapeutics, Inc. Utilization of pharmacological chaperones to improve manufacturing and purification of biologics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003038036A2 (en) * 2001-10-09 2003-05-08 Oregon Health & Science University Rescue of gonadotropin releasing hormone receptor mutants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003038036A2 (en) * 2001-10-09 2003-05-08 Oregon Health & Science University Rescue of gonadotropin releasing hormone receptor mutants

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CONN P MICHAEL ET AL: "Protein origami: therapeutic rescue of misfolded gene products.", MOLECULAR INTERVENTIONS SEP 2002, vol. 2, no. 5, September 2002 (2002-09-01), pages 308 - 316, XP002556613, ISSN: 1543-2548 *
JANOVICK J A ET AL: "Structure-Activity Relations of successful Pharmacologic Chaperones for rescue of Naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 305, no. 2, 11 February 2003 (2003-02-11), pages 608 - 614, XP008107968, ISSN: 0022-3565 *
JANOVICK, JO ANN ET AL: "Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM , 87 (7), 3255 -3262 CODEN: JCEMAZ; ISSN: 0021-972X, 2002, XP002960366 *
LEANOS-MIRANDA ALFREDO ET AL: "Receptor-misrouting: An unexpectedly prevalent and rescuable etiology in GnRHR-mediated hypogonadotropic hypogonadism", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 87, no. 10, October 2002 (2002-10-01), pages 4825 - 4828, XP002556612, ISSN: 0021-972X *

Also Published As

Publication number Publication date
WO2004069859A3 (en) 2009-04-02
AU2004208990A1 (en) 2004-08-19
AU2004208990B2 (en) 2010-11-11
CA2514449A1 (en) 2004-08-19
EP1599494A2 (de) 2005-11-30
WO2004069859A2 (en) 2004-08-19

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