EP1589980A4 - Methods of diagnosis and treatment of interstitial lung disease - Google Patents

Methods of diagnosis and treatment of interstitial lung disease

Info

Publication number
EP1589980A4
EP1589980A4 EP03811670A EP03811670A EP1589980A4 EP 1589980 A4 EP1589980 A4 EP 1589980A4 EP 03811670 A EP03811670 A EP 03811670A EP 03811670 A EP03811670 A EP 03811670A EP 1589980 A4 EP1589980 A4 EP 1589980A4
Authority
EP
European Patent Office
Prior art keywords
diagnosis
treatment
methods
lung disease
interstitial lung
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03811670A
Other languages
German (de)
French (fr)
Other versions
EP1589980A2 (en
Inventor
Jeffrey A Whitsett
Stephan W Glasser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cincinnati Childrens Hospital Medical Center
Original Assignee
Cincinnati Childrens Hospital Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Childrens Hospital Medical Center filed Critical Cincinnati Childrens Hospital Medical Center
Publication of EP1589980A2 publication Critical patent/EP1589980A2/en
Publication of EP1589980A4 publication Critical patent/EP1589980A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
EP03811670A 2002-12-09 2003-12-09 Methods of diagnosis and treatment of interstitial lung disease Withdrawn EP1589980A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43194902P 2002-12-09 2002-12-09
US431949P 2002-12-09
PCT/US2003/038915 WO2004056310A2 (en) 2002-12-09 2003-12-09 Methods of diagnosis and treatment of interstitial lung disease

Publications (2)

Publication Number Publication Date
EP1589980A2 EP1589980A2 (en) 2005-11-02
EP1589980A4 true EP1589980A4 (en) 2007-04-04

Family

ID=32681947

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03811670A Withdrawn EP1589980A4 (en) 2002-12-09 2003-12-09 Methods of diagnosis and treatment of interstitial lung disease

Country Status (7)

Country Link
EP (1) EP1589980A4 (en)
JP (1) JP2006519588A (en)
CN (1) CN100401896C (en)
AU (1) AU2003302740A1 (en)
BR (1) BR0317132A (en)
CA (1) CA2507613A1 (en)
WO (1) WO2004056310A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009183176A (en) * 2008-02-05 2009-08-20 Univ Of Tokyo Il-1 type ii receptor gene deletion mutant mouse
JP5801206B2 (en) * 2009-01-30 2015-10-28 アルファベータ・エービーＡｌｐｈａＢｅｔａ ＡＢ Compounds and methods for the treatment of Alzheimer's disease
WO2011162655A1 (en) 2010-06-24 2011-12-29 Alphabeta Ab Compound and method for treatment of alzheimer's disease and familial dementia
JP6227523B2 (en) 2011-04-05 2017-11-08 アルファベータ・エービーＡｌｐｈａＢｅｔａ ＡＢ Amyrodosis targets useful in therapeutic methods and for compound screening
CN107075470A (en) * 2014-09-18 2017-08-18 北卡罗来纳大学 Mammal lung spheroid and lung sphere cells and its application
CN111972354B (en) * 2019-05-24 2021-11-30 凯斯艾生物科技（苏州）有限公司 Method for constructing interstitial pneumonia model with autoimmune characteristics
EP3811777A1 (en) 2019-10-27 2021-04-28 Shanghai Raas Blood Products Co., Ltd. Genetically modified non-human animals humanised for protein c
CN111296364B (en) * 2019-10-27 2022-06-24 上海莱士血液制品股份有限公司 Gene modification method for mouse animal model and application thereof
CN115772539A (en) * 2022-11-17 2023-03-10 南京医科大学 Bilateral lung deficiency mouse model with I-type tracheodysplasia phenotype and construction method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047623A1 (en) * 1999-02-12 2000-08-17 Chiesi Farmaceutici S.P.A. Artificial peptides having surface activity and the use thereof in the preparation of artificial surfactant
WO2000076535A1 (en) * 1999-06-11 2000-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
WO2001080633A2 (en) * 2000-04-26 2001-11-01 Children's Hospital Medical Center Surfactant protein d for the prevention and diagnosis of pulmonary emphysema
US6458759B1 (en) * 1996-04-26 2002-10-01 Ony, Inc. Compositions and methods for isolating lung surfactant hydrophobic proteins SP-B and SP-C
US20030221199A1 (en) * 1998-10-20 2003-11-27 Whitsett Jeffrey A. Surfactant protein D for the prevention and diagnosis of pulmonary emphysema

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0644200B1 (en) * 1993-01-13 1998-04-29 Ajinomoto Co., Inc. Cell surface protein from brevibacterium lactofermentum

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458759B1 (en) * 1996-04-26 2002-10-01 Ony, Inc. Compositions and methods for isolating lung surfactant hydrophobic proteins SP-B and SP-C
US20030221199A1 (en) * 1998-10-20 2003-11-27 Whitsett Jeffrey A. Surfactant protein D for the prevention and diagnosis of pulmonary emphysema
WO2000047623A1 (en) * 1999-02-12 2000-08-17 Chiesi Farmaceutici S.P.A. Artificial peptides having surface activity and the use thereof in the preparation of artificial surfactant
WO2000076535A1 (en) * 1999-06-11 2000-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
WO2001080633A2 (en) * 2000-04-26 2001-11-01 Children's Hospital Medical Center Surfactant protein d for the prevention and diagnosis of pulmonary emphysema

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AMIN R S ET AL: "Surfactant protein deficiency in familial interstitial lung disease.", THE JOURNAL OF PEDIATRICS. JUL 2001, vol. 139, no. 1, July 2001 (2001-07-01), pages 85 - 92, XP002394844, ISSN: 0022-3476 *
DAVIS A J ET AL: "Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant.", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE FEB 1998, vol. 157, no. 2, February 1998 (1998-02-01), pages 553 - 559, XP002418346, ISSN: 1073-449X *
GLASSER S W ET AL: "Altered stability of pulmonary surfactant in SP-C-deficient mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 22 MAY 2001, vol. 98, no. 11, 22 May 2001 (2001-05-22), pages 6366 - 6371, XP002394842, ISSN: 0027-8424 *
GLASSER STEPHAN W ET AL: "Pneumonitis and emphysema in sp-C gene targeted mice.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 18 APR 2003, vol. 278, no. 16, 18 April 2003 (2003-04-18), pages 14291 - 14298, XP002394847, ISSN: 0021-9258 *
HAFNER D ET AL: "CYCLOOXYGENASE-INHIBITION ENHANCES THE EFFECTS OF RSP-C SURFACTANT THERAPY IN A RAT LAVAGE MODEL OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)", EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, JENA, DE, vol. 55, no. 1, July 2003 (2003-07-01), pages 59 - 68, XP009024125, ISSN: 0940-2993 *
IKEGAMI MACHIKO ET AL: "Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD. : 1985) FEB 2002, vol. 92, no. 2, February 2002 (2002-02-01), pages 519 - 526, XP002394843, ISSN: 8750-7587 *
NOGEE LAWRENCE M ET AL: "Mutations in the surfactant protein C gene associated with interstitial lung disease.", CHEST. MAR 2002, vol. 121, no. 3 Suppl, March 2002 (2002-03-01), pages 20S - 21S, XP009070987, ISSN: 0012-3692 *
SANFORD L P ET AL: "Influence of genetic background on knockout mouse phenotypes.", METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) 2001, vol. 158, 2001, pages 217 - 225, XP009071124, ISSN: 1064-3745 *
THOMAS ALAN Q ET AL: "Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred.", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1 MAY 2002, vol. 165, no. 9, 1 May 2002 (2002-05-01), pages 1322 - 1328, XP002394845, ISSN: 1073-449X *

Also Published As

Publication number Publication date
JP2006519588A (en) 2006-08-31
AU2003302740A1 (en) 2004-07-14
WO2004056310A2 (en) 2004-07-08
CA2507613A1 (en) 2004-07-08
CN1731932A (en) 2006-02-08
WO2004056310A3 (en) 2005-09-01
BR0317132A (en) 2005-10-25
EP1589980A2 (en) 2005-11-02
CN100401896C (en) 2008-07-16

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