EP1587432A4 - Clamp permettant l'occlusion d'une artere uterine - Google Patents

Clamp permettant l'occlusion d'une artere uterine

Info

Publication number
EP1587432A4
EP1587432A4 EP04704961A EP04704961A EP1587432A4 EP 1587432 A4 EP1587432 A4 EP 1587432A4 EP 04704961 A EP04704961 A EP 04704961A EP 04704961 A EP04704961 A EP 04704961A EP 1587432 A4 EP1587432 A4 EP 1587432A4
Authority
EP
European Patent Office
Prior art keywords
clamping
intrauterine
clamping device
uterine
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04704961A
Other languages
German (de)
English (en)
Other versions
EP1587432A2 (fr
Inventor
Fred H Burbank
Michael L Jones
Greig E Altieri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vascular Control Systems Inc
Original Assignee
Vascular Control Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/355,809 external-priority patent/US7404821B2/en
Application filed by Vascular Control Systems Inc filed Critical Vascular Control Systems Inc
Publication of EP1587432A2 publication Critical patent/EP1587432A2/fr
Publication of EP1587432A4 publication Critical patent/EP1587432A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/28—Surgical forceps
    • A61B17/2812—Surgical forceps with a single pivotal connection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00057—Light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/28—Surgical forceps
    • A61B17/2812—Surgical forceps with a single pivotal connection
    • A61B17/2833—Locking means
    • A61B2017/2837—Locking means with a locking ratchet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound

Definitions

  • the invention is generally directed to the treatment of uterine disorders by detecting and regulating blood flow through one or both of the patient's uterine arteries.
  • Hysterectomy surgical removal of the uterus
  • Hysterectomy is often the therapeutic choice for the treatment of uterine cancer, adenomyosis, menorrhagia, prolapse, dysfunctional uterine bleeding (abnormal menstrual bleeding that has no discrete anatomic explanation such as a tumor or growth), and muscular tumors of the uterus, known as leimyoma or uterine fibroids.
  • hysterectomy is a drastic treatment, having many undesirable characteristics. Thus, any method which can approximate the therapeutic result of a hysterectomy without removing the uterus would be a significant improvement in this field. Newer treatment methods have been developed for some diseases which may
  • uterine fibroids could be treated without hysterectomy using a non-surgical therapy, specifically comprising bilateral intraluminal occlusion of the uterine arteries (Ravina et al., "Arterial Embolization to Treat Uterine Myomata", Lancet Sept. 9, 1995; Vol. 346; pp. 671-672, incorporated in its entirety herein). This technique is known as "uterine artery embolization”.
  • uterine arteries are accessed via a transvascular route from a common femoral artery into the left and right uterine arteries by means of an intravascular catheter and embolic material, such as small metallic coils, polyvinyl alchohol particulate and the like, is delivered through the catheter to the uterine arteries which quickly become occluded.
  • embolic material such as small metallic coils, polyvinyl alchohol particulate and the like
  • the uterus has a dual (or redundant) blood supply, the primary blood supply being from the bilateral uterine arteries, and the secondary blood supply from the bilateral ovarian arteries. Consequently, when both uterine arteries are occluded, i.e. bilateral vessel occlusion, the uterus and the fibroids contained within the uterus are both deprived of their blood supply.
  • both uterine arteries are occluded, i.e. bilateral vessel occlusion
  • the uterus and the fibroids contained within the uterus are both deprived of their blood supply.
  • the invention is directed to a relatively non-invasive uterine artery occlusion device and system and the procedure for using the device and system for occluding a female patient's uterine artery.
  • the instruments and their use may be utilized in the treatment of uterine fibroids, dysfunctional uterine bleeding, post partum hemorrhage and other uterine disorders by reducing or terminating blood flow through a patient's uterine artery.
  • a device embodying features of the invention includes an intrauterine clamp which has a pressure applying or clamping member configured to apply pressure against the exterior of the patient's uterine cervix or against the patient's vaginal fornix.
  • the intravaginal clamp also has a stabilizing or positioning member which is configured to be inserted into the patient's uterine cervix so as to stabilize at least a portion of the interior of the uterine cervix and facilitate the more effective application of pressure by the pressure applying member to the exterior of the cervix or the vaginal fornix to ensure effective occlusion of the patient's uterine artery.
  • the uterine artery occlusion is temporary, and may be partial or complete.
  • One method of occluding a blood vessel comprises clamping the blood vessel effective to compress it so that blood flow through the vessel is reduced, or is abolished.
  • Such clamping of a blood vessel may be direct or may be indirect.
  • clamping of a blood vessel effective to compress it is accomplished by applying a non-invasive blood vessel occlusion device to tissue near to a blood vessel (e.g., onto tissue surrounding the vessel).
  • a blood vessel occlusion device may also be applied directly onto a blood vessel effective to compress the blood vessel.
  • a non-invasive blood vessel occluding device (such as a clamp with a sensor) may be applied to a portion of a vaginal wall to detect and/or locate, and to occlude the uterine arteries.
  • a vaginal clamp embodying features of the invention may used to sense the location of a uterine artery adjacent a vaginal wall, and may be used to compress and occlude a uterine artery adjacent a vaginal wall.
  • the vaginal wall may be distended by an occlusion device so as to more closely approach a uterine artery; such an approach may aided by applying pressure or force to the uterus (e.g., by pulling on the uterine cervix).
  • a uterine cervix may be grasped or pulled by any suitable device or implement, including forceps, suction devices, and other instruments, such as a tenaculum.
  • a non-invasive blood vessel occluding device embodying features of the invention may be a non-invasive intravaginal uterine artery occlusion device, comprising a pair of pressure-applying members having opposed tissue-contacting surfaces on distal portions thereof; at least one supporting shaft extending from a proximal extremity of at least one of the pressure-applying members which is configured to adjust the distance between the opposed tissue-contacting surfaces of the pressure-applying members; and at least one blood flow sensing sensor on one of the opposed tissue-contacting surfaces.
  • An embodiment of a non-invasive blood vessel occlusion device embodying features of the invention may have, for example, a handle, a clamping member configured to apply pressure or force to body tissue, and a sensor for locating a blood vessel.
  • a pressure-applying member such as a clamping member
  • a supporting shaft such as a handle, is preferably configured for manipulating the jaw or jaws.
  • a pressure-applying member may be attached to a connecting portion that is configured so that a jaw may be placed within a vagina while a handle remains outside a patient's body and available for use by an operator.
  • the clamping member is preferably provided with a blood flow sensor for locating the blood vessel to be occluded.
  • the sensor may sense sound, pressure, strain, stress, chemical entity, electromagnetic radiation and the like, and may be a combination of such sensors.
  • a sensor is preferably a Doppler ultrasound sensor.
  • the sensor is mounted to the face of a tissue-contacting surface of the clamping member, such as the face of a jaw of a clamp, and is preferably oriented perpendicularly to the clamp face, although other orientations may be employed.
  • Ultrasound energy useful for sensing a location of a blood vessel or of blood flow in a blood vessel has a frequency of less than about 20 MegaHertz (MHz), such as between about 5 MHz and about 19 MHz, and preferably between about 6 MHz and about 10 MHz. In commercially available Doppler sensors the frequency is typically about 8 MHz.
  • the EM energy should have a wavelength of about 500 nanometers (nm) to about 2000 nm, preferably about 700 nm to about 1000 nm.
  • a system embodying features of the invention includes an blood vessel occluding device as described above with a blood flow sensor on the clamping member for locating the target blood vessel, and a sensor controller which may include an energy source for the sensor.
  • the sensor controller may be configured to aid in detecting a location of a blood vessel, by, e.g., providing a signal related to the output of a sensor that may be readily used by an operator.
  • a sensor controller may include an energy source configured to provide energy for operating a blood flow sensor.
  • a method for occluding a uterine artery which embodies features of the invention include advancing the clamping device through the patient's vaginal canal, guiding the stabilizing member of the clamping device through the cervical os, into the cervical canal with the clamping member spaced from the stabilizing member so that the pressure applying surfaces of the clamping member is pressed into the patient's vaginal fornix. Adjustment of the clamping member allows the sensor on the distal end thereof to locate the uterine artery a short distance from the surface of the vaginal fornix. With the clamping member adjacent to the target blood vessel, the clamping device can be closed to compress underlying tissue and thereby occlude the uterine artery.
  • the uterine artery is located with the blood flow sensor on the distal end of the clamping member. Tension may be applied to the uterine cervix with a grasping implement (e.g., by pulling on the uterine cervix) while applying force or pressure to a vaginal wall to occlude a uterine artery.
  • the invention allows for the non-surgical location and occlusion of blood vessels such as the uterine artery, providing effective therapeutic treatment.
  • the present invention allows for the occlusion of a female patient's uterine artery without the need for radiographic equipment or for extensive training in the use of radiographic techniques.
  • the devices and methods are simple and readily used for treating uterine fibroids, dysfunctional uterine bleeding (DUB), adenomyosis, post-partum hemorrhage, and other uterine disorders.
  • the devices, systems and methods embodying features of the invention allow for the separate occlusion of individual uterine arteries which provides effective therapy in those situations in which the uterine anatomy will not allow for the use of a single bilateral artery occlusion device.
  • Figure 1 is an elevational view of a uterine artery clamping device embodying features of the invention in an open configuration.
  • Figure 2 is a perspective view of the clamping device shown in Fig. 1.
  • Figure 3 is an enlarged perspective view of the distal portion of an alternative clamping device having a serrated surface and a plurality of teeth to grasp tissue.
  • Figure 4 is an enlarged perspective view of an alternative clamping device in which the clamping element and the stabilizer element are provided with teeth to grasp tissue.
  • Figure 5 is a schematic illustration of the intra-uterine clamp in position to occlude a female patient's uterine artery.
  • Figure 6 is a perspective view of an alternative embodiment in which the clamping element and the stabilizing element are angled with respect to the handles of the clamp.
  • Figure 7 is a perspective view of an alternative embodiment in which the spacing between the stabilizing member and the clamping member is adjusted by a spring coil.
  • Figure 8 is perspective view of an alternative embodiment in which the spacing between the stabilizing member and the damping member is adjusted by a rack and pinion arrangement.
  • FIGS 1 and 2 show a relatively non-invasive intra-uterine occluding clamp 10 embodying features of the invention.
  • the clamp 10 includes a clamping member 11 having an elongated handle 12 with a finger grip 13, and pressure- applying clamping element or jaw 14 on the distal end of the clamping element.
  • the intra-uterine clamp also includes stabilizing member 15 which is configured to readily follow or track the patient's cervical os and cervical canal.
  • the stabilizing member 15 has an elongated handle 16 with a finger grip 17.
  • a uterine artery clamp embodying features of the invention is preferably provided with a blood flow sensor 22, preferably a Doppler ultrasonic sensing system, on the leading surface of the jaw 14. This sensor location allows the operator to more easily guide the jaw 14 to the location of the patient's target uterine artery.
  • Sensor 22 is provided with a signal transmission cable 23 which is operatively connected to sensor control device 24.
  • Cable 23 may be an insulated wire, plurality of wires, optical fiber, waveguide, or other connection effective to carry signals and/or energy or power between a sensor 22 and sensor controller 24.
  • Sensor 22 may be a blood flow sensor for locating a blood vessel, and may be a passive sensor, configured to detect intrinsic signals indicating the presence of a blood vessel (i.e., a sound sensor, a motion sensor, a pH sensor, or other sensor configured to detect a physical, chemical, electrical, or physiological indication of the location of a blood vessel).
  • a blood flow sensor for locating a blood vessel may be an active sensor, configured to emit energy or a signal, and configured to detect signals in response to, or derived from, the emitted energy or signal indicating the presence of a blood vessel (i.e., a source of ultrasound having an ultrasound sensor configured to detect ultrasound reflections from a blood vessel, a source of infrared radiation configured to detect reflections from a blood vessel, or other source of energy and a sensor configured to detect a response indicating the location of a blood vessel).
  • a source of ultrasound having an ultrasound sensor configured to detect ultrasound reflections from a blood vessel, a source of infrared radiation configured to detect reflections from a blood vessel, or other source of energy and a sensor configured to detect a response indicating the location of a blood vessel.
  • the operation of a sensor may be aided by an energy source such as the sensor controller 24.
  • an energy source may provide electrical energy which aids an ultrasound sensor to produce and to detect ultrasound energy (as, e.g., in the MedaSonics® CardioBeat® Blood Flow Doppler with Integrated Speaker (Cooper Surgical, Inc., Trumbull CT 06611 )).
  • Other commercially available Doppler ultrasound sensors suitable for use in the present invention include the Koven model ES 100X MiniDop VRP-8 probe (St. Louis, MO) and the DWL/Neuro Scan Medical Systems' Multi-Dop B+ system (Sterling, VA).
  • jaw 14 may be provided with a serrated, tissue- grasping surface 25 configured to engage and hold onto tissue when jaw 14 is pressed into tissue of the patient's vaginal fornix.
  • tissue- grasping surface 25 configured to engage and hold onto tissue when jaw 14 is pressed into tissue of the patient's vaginal fornix.
  • one or both of the jaw 14 and/or stabilizer 15 may have retractable fingers or teeth 26 to better secure the contacting members to the target tissue.
  • Figure 5 illustrates an alternative embodiment wherein the clamping member 11 and the stabilizing member 15 are oriented at an angle ⁇ with respect to the handles 12 and 16.
  • the angulation provides a more direct attack angle to facilitate insertion of the stabilizing member 15 into the patient's cervix and direction of the jaw 14 toward a desired location at the patient's vaginal fornix to facilitate location and occlusion of the patient's uterine artery.
  • Closure of a blood vessel is effected by pressure applied through the wall of the patient's vaginal fornix. Sufficient pressure or force applied to the tissue of the vaginal wall to compress and to at least partially occlude the underlying uterine artery.
  • the blood flow sensor for detecting or locating the uterine artery should be disposed on the leading face off the clamping element and generally perpendicular to the tissue-contacting surface of a jaw 14 to be effective.
  • a non-invasive blood vessel occluding device embodying features of the invention may be configured to lock into a clamping position. Such a locked configuration may be temporary and releasable, or may be permanent.
  • Non-invasive blood vessel occluding devices embodying features of the invention may have a locking mechanism, such as a ratchet, configured to hold at least one pressure- applying member in a pressure-applying position.
  • Such locking mechanisms may include a release mechanism effective to allow the cessation of pressure or force application when desired.
  • a non-invasive blood vessel occlusion device embodying features of the invention may be configured to release a locking mechanism effective to relieve the occlusion of a blood vessel by ending the application of pressure or force that had been previously applied to occlude a blood vessel.
  • a vagina determines what size clamping device is suitable, taking into consideration that the clamping device should readily reach the vaginal fornix and be operated from outside of a patient's body.
  • a clamping device may be between about 5 to about 16 inches in length, preferably between about 6 inch to about 12 inches in length for most applications.
  • FIG. 6 schematically illustrates in part a human female reproductive system, including a uterus 30, uterine cervix 31 , uterine artery 32, vaginal canal 33 and vaginal fornix 34.
  • a method of using the uterine artery clamp embodying features of the invention includes introducing the clamp 10 into the patient's vaginal canal 33 and advancing the clamp therein until the distal portions of the clamp are adjacent to the patient's uterine cervix 31.
  • the position of the handles 12 and 16 are adjusted to increase the spacing between the jaw 14 and the distal portion of the stabilizer 16.
  • the distal end of the stabilizer is guided through the cervical os 35 into the uterine cervix.
  • the distal end of jaw 14 is urged against the vaginal fornix 34 and 14.
  • the pressure applying surface of the jaw is positioned as close as possible to the patient's uterine artery 32.
  • Sufficient pressure is applied to the uterine artery 32 or the tissue surrounding the uterine artery by jaw 14 to facilitate occlusion of the uterine artery.
  • the handles 12 and 16 are locked by ratchet members 19 and 20 to press the jaw 14 against the tissue between the jaw 14 and the stabilizer 15.
  • the clamped position is maintained for about 0.5 to about 48 hours, preferably about 1 to about 24 hours for effective therapeutic treatment of a uterine disorder, e.g. for fibroids, PPH, DUB and the like.
  • Blood flow sensor 22 is effective to locate uterine artery 48 by detecting blood flow and monitoring the treatment by detecting the lack of blood flow in the artery.
  • Blood flow in the left uterine artery 50 may be similarly occluded, by a separate uterine artery clamp of the same design or the same clamp can be used on the other side after release of the occlusion of the right uterine artery 34.
  • FIG. 7 and 8 illustrate alternate clamp design wherein the spacing between the jaw 14 and stabilizer 15 is controlled by a spring 40 as shown in Fig. 7 and a rack and pinion mechanism 50 as shown in Fig. 8. A variety of other means may be employed to open and close the jaw 14 and stabilizer 15.
  • Uterine artery clamp 10 embodying features of the invention may be made from any suitable material or combination of materials, including metals such as stainless steel and superelastic shape memory alloys such as nickel titanium alloys having a stable austenite phase at body temperature, high strength plastics, ceramics, and other materials known in the art.
  • metals such as stainless steel and superelastic shape memory alloys such as nickel titanium alloys having a stable austenite phase at body temperature, high strength plastics, ceramics, and other materials known in the art.
  • Biocompatible polymers such as polycarbonate, polysulfone, polyester, polyacetal and a variety of fluoropolymers can be suitable for a variety of embodiments of the invention.
  • the device or system may be designed for single use (disposable) or may be sterilizable and capable of multiple use.

Abstract

La présente invention se rapporte à un clamp pour artère utérine, et à une méthode de traitement relativement non effractive faisant appel audit clamp. Le clamp utérin selon l'invention comprend un élément de clampage possédant une mâchoire dotée de surfaces venant en contact avec les tissus qui permettent d'appliquer une pression sur un tissu cible, et un élément de stabilisation qui est adapté de manière à être introduit dans le canal cervical utérin d'une patiente. Le clamp selon l'invention peut être doté de poignées allongées permettant de régler manuellement l'espacement entre la mâchoire et le stabilisateur, et d'appliquer ainsi une pression sur une artère utérine en dessous d'un paquet de tissu maintenu entre la mâchoire et le stabilisateur. Des clamps utérins possédant les caractéristiques selon l'invention peuvent être utilisés dans des méthodes permettant de traiter des troubles utérins tels que les fibromyomes utérins, la ménométrorragie, l'hémorragie de la délivrance, et analogues.
EP04704961A 2003-01-30 2004-01-23 Clamp permettant l'occlusion d'une artere uterine Withdrawn EP1587432A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/355,809 US7404821B2 (en) 2003-01-30 2003-01-30 Treatment for post partum hemorrhage
US355809 2003-01-30
US430880 2003-05-06
US10/430,880 US7329265B2 (en) 2003-01-30 2003-05-06 Uterine artery occlusion clamp
PCT/US2004/001935 WO2004069025A2 (fr) 2003-01-30 2004-01-23 Clamp permettant l'occlusion d'une artere uterine

Publications (2)

Publication Number Publication Date
EP1587432A2 EP1587432A2 (fr) 2005-10-26
EP1587432A4 true EP1587432A4 (fr) 2008-12-31

Family

ID=32853081

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04704961A Withdrawn EP1587432A4 (fr) 2003-01-30 2004-01-23 Clamp permettant l'occlusion d'une artere uterine

Country Status (5)

Country Link
EP (1) EP1587432A4 (fr)
JP (1) JP4455581B2 (fr)
AU (1) AU2004210130B2 (fr)
CA (1) CA2514545C (fr)
WO (1) WO2004069025A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070005061A1 (en) * 2005-06-30 2007-01-04 Forcept, Inc. Transvaginal uterine artery occlusion
US20090093758A1 (en) 2006-07-24 2009-04-09 Yossi Gross Fibroid treatment apparatus and method
JP5308741B2 (ja) * 2008-08-25 2013-10-09 オリンパスメディカルシステムズ株式会社 医療機器
US8403953B2 (en) 2009-07-27 2013-03-26 Fibro Control, Inc. Balloon with rigid tube for occluding the uterine artery
TW201129344A (en) * 2010-02-23 2011-09-01 Ying-Jie Su Disease search device
JP5684433B2 (ja) * 2013-01-18 2015-03-11 オリンパスメディカルシステムズ株式会社 処置具
WO2016027529A1 (fr) 2014-08-22 2016-02-25 オリンパス株式会社 Dispositif de préhension de tissu
RU2701210C1 (ru) * 2019-02-04 2019-09-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) Способ прогнозирования экспульсии миоматозного узла после эмболизации маточных артерий у пациентки с миомой матки

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US4120302A (en) * 1976-10-08 1978-10-17 American Hospital Supply Corporation Disposable pads for surgical instruments
US6293954B1 (en) * 1999-06-21 2001-09-25 Novare Surgical Systems, Inc. Surgical clamp with replaceable clamp members
US20020124853A1 (en) * 2000-04-21 2002-09-12 Fred Burbank Methods for minimally-invasive, non-permanent occlusion of a uterine artery
US20020183771A1 (en) * 2001-03-28 2002-12-05 Vascular Control Systems, Inc. Method and apparatus for the detection and ligation of uterine arteries
EP1587436A2 (fr) * 2003-01-30 2005-10-26 Vascular Control Systems, Inc. Traitement de l'hemorragie de la delivrance

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GB2302025A (en) * 1995-06-10 1997-01-08 Mark Steven Whiteley Vascular doppler forceps
US5697937A (en) * 1996-02-23 1997-12-16 Toma; Doina Surgical clamp with manipulable guide means
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Publication number Priority date Publication date Assignee Title
US3779248A (en) * 1971-10-18 1973-12-18 Medical Concepts Inc Forceps
US4120302A (en) * 1976-10-08 1978-10-17 American Hospital Supply Corporation Disposable pads for surgical instruments
US6293954B1 (en) * 1999-06-21 2001-09-25 Novare Surgical Systems, Inc. Surgical clamp with replaceable clamp members
US20020124853A1 (en) * 2000-04-21 2002-09-12 Fred Burbank Methods for minimally-invasive, non-permanent occlusion of a uterine artery
US20020183771A1 (en) * 2001-03-28 2002-12-05 Vascular Control Systems, Inc. Method and apparatus for the detection and ligation of uterine arteries
US20020188306A1 (en) * 2001-03-28 2002-12-12 Burbank Fred H. Multi-axial uterine artery identification, characterization, and occlusion pivoting devices and methods
EP1587436A2 (fr) * 2003-01-30 2005-10-26 Vascular Control Systems, Inc. Traitement de l'hemorragie de la delivrance

Also Published As

Publication number Publication date
JP4455581B2 (ja) 2010-04-21
CA2514545A1 (fr) 2004-08-19
AU2004210130B2 (en) 2009-01-29
AU2004210130A1 (en) 2004-08-19
EP1587432A2 (fr) 2005-10-26
WO2004069025A2 (fr) 2004-08-19
CA2514545C (fr) 2011-03-15
WO2004069025A3 (fr) 2005-04-28
JP2006517444A (ja) 2006-07-27

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