EP1581261A4 - Cytotoxines et agents d'imagerie de diagnostic comprenant des ligands hsp90 - Google Patents

Cytotoxines et agents d'imagerie de diagnostic comprenant des ligands hsp90

Info

Publication number
EP1581261A4
EP1581261A4 EP03741983A EP03741983A EP1581261A4 EP 1581261 A4 EP1581261 A4 EP 1581261A4 EP 03741983 A EP03741983 A EP 03741983A EP 03741983 A EP03741983 A EP 03741983A EP 1581261 A4 EP1581261 A4 EP 1581261A4
Authority
EP
European Patent Office
Prior art keywords
cytotoxins
diagnostic imaging
imaging agents
hsp90 ligands
hsp90
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03741983A
Other languages
German (de)
English (en)
Other versions
EP1581261A1 (fr
Inventor
Adeela Kamal
Francis Burrows
Lin Zhang
Marcus Boehm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Conforma Therapeutics Corp
Original Assignee
Conforma Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/039993 external-priority patent/WO2003050295A2/fr
Application filed by Conforma Therapeutics Corp filed Critical Conforma Therapeutics Corp
Publication of EP1581261A1 publication Critical patent/EP1581261A1/fr
Publication of EP1581261A4 publication Critical patent/EP1581261A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
EP03741983A 2002-12-12 2003-06-12 Cytotoxines et agents d'imagerie de diagnostic comprenant des ligands hsp90 Withdrawn EP1581261A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2002/039993 WO2003050295A2 (fr) 2001-12-12 2002-12-12 Essais et mises en oeuvre permettant de determiner et de moduler une activite de liaison hsp90
WOPCT/US02/39993 2002-12-12
PCT/US2003/018776 WO2004054624A1 (fr) 2002-12-12 2003-06-12 Cytotoxines et agents d'imagerie de diagnostic comprenant des ligands hsp90

Publications (2)

Publication Number Publication Date
EP1581261A1 EP1581261A1 (fr) 2005-10-05
EP1581261A4 true EP1581261A4 (fr) 2009-10-21

Family

ID=32592278

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03741983A Withdrawn EP1581261A4 (fr) 2002-12-12 2003-06-12 Cytotoxines et agents d'imagerie de diagnostic comprenant des ligands hsp90

Country Status (4)

Country Link
EP (1) EP1581261A4 (fr)
AU (1) AU2003303058A1 (fr)
CA (1) CA2549463A1 (fr)
WO (1) WO2004054624A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP4791183B2 (ja) 2002-08-23 2011-10-12 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロン、その中間体、類似体の合成およびその使用
US7691838B2 (en) * 2003-05-30 2010-04-06 Kosan Biosciences Incorporated Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics
US20050020556A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes
GB0526615D0 (en) * 2005-12-30 2006-02-08 Novartis Ag Organic compounds
GB0603880D0 (en) * 2006-02-27 2006-04-05 Novartis Ag Organic compounds
CN100519536C (zh) * 2006-03-21 2009-07-29 中国医学科学院医药生物技术研究所 一组连有核苷碱基的格尔德霉素衍生物
EP2200653A2 (fr) 2007-09-10 2010-06-30 University of Massachusetts Agents antitumoraux ciblant les mitochondries
WO2010028389A1 (fr) * 2008-09-08 2010-03-11 The Methodist Hospital Research Institute Dépôt d’énergie assisté par imagerie pour l’administration ciblée de médicaments
US20140079636A1 (en) 2012-04-16 2014-03-20 Dinesh U. Chimmanamada Targeted therapeutics
WO2015038649A1 (fr) 2013-09-10 2015-03-19 Synta Pharmaceuticals Corp. Thérapeutique ciblée
WO2015066053A2 (fr) 2013-10-28 2015-05-07 Synta Pharmaceuticals Corp. Thérapies ciblées
WO2015116774A1 (fr) 2014-01-29 2015-08-06 Synta Pharmaceuticals Corp. Agents thérapeutiques cibles
WO2015134464A2 (fr) 2014-03-03 2015-09-11 Synta Pharmaceuticals Corp. Thérapies ciblées
WO2015143004A1 (fr) 2014-03-18 2015-09-24 Synta Pharmaceuticals Corp. Agents thérapeutiques cibles
EP3641647A4 (fr) 2017-06-20 2021-05-05 Madrigal Pharmaceuticals, Inc. Agents thérapeutiques ciblés
IL299892A (en) 2017-06-20 2023-03-01 Madrigal Pharmaceuticals Inc Combination therapies that include prescribed medications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000003737A2 (fr) * 1998-07-17 2000-01-27 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Medicaments solubles a l'eau et procedes de preparation de ceux-ci
WO2003045319A2 (fr) * 2001-11-21 2003-06-05 Activbiotics, Inc. Agents therapeutiques cibles et leurs utilisations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000003737A2 (fr) * 1998-07-17 2000-01-27 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Medicaments solubles a l'eau et procedes de preparation de ceux-ci
WO2003045319A2 (fr) * 2001-11-21 2003-06-05 Activbiotics, Inc. Agents therapeutiques cibles et leurs utilisations

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 224, no. 1-2, 2002, 224TH NATIONAL MEETING OF THE AMERICAN CHEMICAL SOCIETY; BOSTON, MA, USA; AUGUST 18-22, 2002, pages BIOT 64, ISSN: 0065-7727 *
CHIOSIS GABRIELA ET AL: "A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells", CHEMISTRY AND BIOLOGY, vol. 8, no. 3, March 2001 (2001-03-01), LONDON, pages 289 - 299, XP002542023, ISSN: 1074-5521 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, MANDLER RAYA ET AL: "Strategies in conjugating geldanamycin derivatives to monoclonal antibodies that enhance herceptin efficacy in mice bearing HER2-overexpressing xenografts", XP002542020, Database accession no. PREV200200490291 *
FUKAZAWA H ET AL: "Labeling of v-Src and BCR-ABL tyrosine kinases with [<14>C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism", FEBS LETTERS, vol. 340, no. 3, 1994, NL, pages 155 - 158, XP002542022, ISSN: 0014-5793 *
MANDLER R ET AL: "Synthesis and evaluation of antiproliferative activity of a geldanamycin-Herceptin TM immunoconjugate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 10, 1 May 2000 (2000-05-01), PERGAMON, ELSEVIER SCIENCE, GB, pages 1025 - 1028, XP004204597, ISSN: 0960-894X *
SCHNUR R C ET AL: "Preparation of 17-amino-22-(4'-azido-3'-<125>iodophenacyl)-17- demethoxygeldanamycin (1): An ansamycin for photoaffinity labeling", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 34, no. 6, 1994, GB, pages 529 - 536, XP002542021, ISSN: 0362-4803 *
See also references of WO2004054624A1 *

Also Published As

Publication number Publication date
AU2003303058A1 (en) 2004-07-09
EP1581261A1 (fr) 2005-10-05
CA2549463A1 (fr) 2004-07-01
WO2004054624A1 (fr) 2004-07-01

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DAX Request for extension of the european patent (deleted)
RIN1 Information on inventor provided before grant (corrected)

Inventor name: BOEHM, MARCUS

Inventor name: ZHANG, LIN

Inventor name: BURROWS, FRANCIS

Inventor name: KAMAL, ADEELA

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 43/00 20060101ALI20090907BHEP

Ipc: A61M 36/14 20060101ALI20090907BHEP

Ipc: A61K 51/00 20060101AFI20040705BHEP

A4 Supplementary search report drawn up and despatched

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