EP1569648A4 - Prodrugs für ophthalmika - Google Patents

Prodrugs für ophthalmika

Info

Publication number
EP1569648A4
EP1569648A4 EP03796804A EP03796804A EP1569648A4 EP 1569648 A4 EP1569648 A4 EP 1569648A4 EP 03796804 A EP03796804 A EP 03796804A EP 03796804 A EP03796804 A EP 03796804A EP 1569648 A4 EP1569648 A4 EP 1569648A4
Authority
EP
European Patent Office
Prior art keywords
prodrugs
ophthalmic agents
ophthalmic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03796804A
Other languages
English (en)
French (fr)
Other versions
EP1569648A1 (de
Inventor
Laszlo Prokai
Katalin Prokai
James Simpkins
Neeraj Agarwal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
University of North Texas
University of North Texas Health Science Center
Original Assignee
University of Florida
University of North Texas
University of North Texas Health Science Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/405,413 external-priority patent/US7026306B2/en
Application filed by University of Florida, University of North Texas, University of North Texas Health Science Center filed Critical University of Florida
Publication of EP1569648A1 publication Critical patent/EP1569648A1/de
Publication of EP1569648A4 publication Critical patent/EP1569648A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
EP03796804A 2002-12-09 2003-12-09 Prodrugs für ophthalmika Withdrawn EP1569648A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43235402P 2002-12-09 2002-12-09
US432354P 2002-12-09
US405413 2003-04-01
US10/405,413 US7026306B2 (en) 2002-04-01 2003-04-01 Steroidal quinols and their use for antioxidant therapy
PCT/US2003/038987 WO2004069248A1 (en) 2002-12-09 2003-12-09 Prodrugs for use a ophthalmic agents

Publications (2)

Publication Number Publication Date
EP1569648A1 EP1569648A1 (de) 2005-09-07
EP1569648A4 true EP1569648A4 (de) 2006-10-04

Family

ID=32853159

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03796804A Withdrawn EP1569648A4 (de) 2002-12-09 2003-12-09 Prodrugs für ophthalmika

Country Status (3)

Country Link
EP (1) EP1569648A4 (de)
AU (1) AU2003297739A1 (de)
WO (1) WO2004069248A1 (de)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2910486A (en) * 1957-12-20 1959-10-27 Searle & Co 10-hydroxyestra-1, 4-diene-3, 17-dione and acetate
US5041434A (en) * 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
DE19654750A1 (de) * 1996-12-30 1998-07-02 Helmut Dr Med Zander Verwendung von Wirkstoffen mit Östrogen-Wirkung zur Vorbeugung und Behandlung von Makuladegeneration
WO2002036605A2 (en) * 2000-11-03 2002-05-10 Washington University Estrone-derivatives having cytoprotective activity
WO2003084978A1 (en) * 2002-04-01 2003-10-16 University Of Florida Steroidal quinols as prodrugs of antioxidants

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004779A1 (en) * 1995-08-02 1997-02-13 Chiroscience Limited Quinolones and their therapeutic use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2910486A (en) * 1957-12-20 1959-10-27 Searle & Co 10-hydroxyestra-1, 4-diene-3, 17-dione and acetate
US5041434A (en) * 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
DE19654750A1 (de) * 1996-12-30 1998-07-02 Helmut Dr Med Zander Verwendung von Wirkstoffen mit Östrogen-Wirkung zur Vorbeugung und Behandlung von Makuladegeneration
WO2002036605A2 (en) * 2000-11-03 2002-05-10 Washington University Estrone-derivatives having cytoprotective activity
WO2003084978A1 (en) * 2002-04-01 2003-10-16 University Of Florida Steroidal quinols as prodrugs of antioxidants

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIGSBY R M ET AL: "Protective effects of estrogen in a rat model of age-related cataracts", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 96, August 1999 (1999-08-01), pages 9328 - 9332, XP002980815, ISSN: 0027-8424 *
MCKINNEY K A ET AL: "Hormone replacement therapy and the eye", JOURNAL OF THE BRITISH MENOPAUSE SOCIETY, BRITISH MENOPAUSE SOCIETY, MARLOW, GB, vol. 6, no. 1, 2000, pages 15 - 17, XP002980814, ISSN: 1362-1807 *
PROKAI L ET AL: "CHEMICAL SHIELD MECHANISM FOR ESTROGEN NEUROPROTECTION: STEROIDAL QUINOLS AS NEW MOLECULE LEADS", AMERICAN CHEMICAL SOCIETY. ABSTRACTS OF PAPER. AT THE NATIONAL MEETING, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 225, no. 1/2, 23 March 2003 (2003-03-23) - 27 March 2003 (2003-03-27), XP008042778, ISSN: 0065-7727 *
PROKAI L: "QUINOL-BASED METABOLIC CYCLE FOR ESTROGENS IN RAT LIVER MICROSOMES", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS., BALTIMORE, MD, US, vol. 31, no. 6, June 2003 (2003-06-01), pages 701 - 704, XP008042777, ISSN: 0090-9556 *
See also references of WO2004069248A1 *

Also Published As

Publication number Publication date
AU2003297739A8 (en) 2004-08-30
EP1569648A1 (de) 2005-09-07
WO2004069248A1 (en) 2004-08-19
AU2003297739A1 (en) 2004-08-30

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20050616

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20060905

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/567 20060101ALI20060830BHEP

Ipc: A61K 31/565 20060101ALI20060830BHEP

Ipc: A61K 31/566 20060101ALI20060830BHEP

Ipc: A61K 31/47 20060101AFI20040824BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: AGARWAL, NEERAJ

Inventor name: SIMPKINS, JAMES

Inventor name: PROKAI, KATALIN

Inventor name: PROKAI, LASZLO

RIN1 Information on inventor provided before grant (corrected)

Inventor name: AGARWAL, NEERAJ

Inventor name: SIMPKINS, JAMES

Inventor name: PROKAI, KATALIN

Inventor name: PROKAI, LASZLO

17Q First examination report despatched

Effective date: 20070604

GRAP Despatch of communication of intention to grant a patent

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RIC1 Information provided on ipc code assigned before grant

Ipc: C07J 1/00 20060101ALI20100914BHEP

Ipc: A61K 9/08 20060101ALI20100914BHEP

Ipc: A61P 27/02 20060101ALI20100914BHEP

Ipc: A61K 31/566 20060101ALI20100914BHEP

Ipc: A61K 31/565 20060101AFI20100914BHEP

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20110218