EP1565387A1 - Plaquette alveolaire - Google Patents

Plaquette alveolaire

Info

Publication number
EP1565387A1
EP1565387A1 EP02777502A EP02777502A EP1565387A1 EP 1565387 A1 EP1565387 A1 EP 1565387A1 EP 02777502 A EP02777502 A EP 02777502A EP 02777502 A EP02777502 A EP 02777502A EP 1565387 A1 EP1565387 A1 EP 1565387A1
Authority
EP
European Patent Office
Prior art keywords
dosage apparatus
monitored dosage
monitored
adhesive
base member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02777502A
Other languages
German (de)
English (en)
Inventor
David John Fenn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SINGULAR PRODUCTS Ltd
Original Assignee
Wright Fenn and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wright Fenn and Co Ltd filed Critical Wright Fenn and Co Ltd
Publication of EP1565387A1 publication Critical patent/EP1565387A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/04—Articles or materials wholly enclosed in single sheets or wrapper blanks
    • B65D75/20—Articles or materials wholly enclosed in single sheets or wrapper blanks in sheets or blanks doubled around contents and having their opposed free margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/22—Articles or materials wholly enclosed in single sheets or wrapper blanks in sheets or blanks doubled around contents and having their opposed free margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding the sheet or blank being recessed to accommodate contents
    • B65D75/24—Articles or materials wholly enclosed in single sheets or wrapper blanks in sheets or blanks doubled around contents and having their opposed free margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding the sheet or blank being recessed to accommodate contents and formed with several recesses to accommodate a series of articles or quantities of material

Definitions

  • the invention relates to a monitored dosage apparatus for containing and presenting medication, particularly medication in the form of tablets, pills, or capsules.
  • Monitored dosage apparatus are designed to contain and present medication safely and securely for dosage to patients on a regular basis. Such patients are often in care homes or hospitals and nurses or carers are required to provide the patient with regular medication in a reliable manner.
  • Monitored dosage systems essentially take the form of a container with, for example, twenty eight pockets marked with the day of the week and date or day, into which a pharmacist places the prescribed dose for that particular patient on that day.
  • the container is then sealed and provided to the nurse or carer who may open the appropriate sealed pocket on the appropriate day.
  • Conventional monitored dosage systems consist of a plastics member provided with at least seven formations for creating individual pockets, each for receiving a particular day's medication.
  • the pharmacist sorts the relevant medication into the relevant pockets and then places the plastics member on a framework in a holding fixture. The pockets are then closed by heat-sealing an aluminium foil, for example, to the plastics member. When it is time to dose the patient, the medication may be released from the pockets by manually pushing through the aluminium foil.
  • a container is classed as Grade A if the moisture transmission is less than 0.5 g/m 2 per day and as Grade B if the vapour transmission is less than 5 g/m 2 per day. No conventional monitored dosage systems perform better than Grade B.
  • a monitored dosage apparatus including: a base member including a plastics sheet having a plurality of formations therein, each providing an open-topped receptacle for receiving medication; a lid member including a plastics sheet for sealing to the base member to close and seal the receptacles, the seal being formed by an adhesive; and means for selectively opening individual sealed receptacles, to release the medication contained therein.
  • the base member and the lid member are formed as a unitary component.
  • a plastics hinge may be provided between the base member and the lid member so that the lid member may be hinged between an open position and a closed position where it closes the receptacles.
  • base member and the lid member may be formed as separate components.
  • the base member and the lid member are formed from polypropylene which is preferably between 200 and 400 micrometers thick and most preferably about 300 micrometers thick.
  • the receptacles may be generally cuboid in shape.
  • each receptacle is between 15mm and 40mm in length, between 5mm and 25mm in width and between 5mm and 25mm in depth. Most preferably, each receptacle is about 25mm in length, 15mm in width and 10mm in depth.
  • the base member includes at least 28 receptacles.
  • the means for selectively opening the individual sealed receptacles may include means for removing a part of the plastics sheet of the lid member covering the top of the receptacle to be opened. These means may include a weakened region in the plastics sheet defining a perimeter of the portion of plastics sheet to be removed. A protruding tab may be attached to the portion of the sheet to be removed, manipulation of the tab enabling the weakened region to tear, thereby allowing the removal of the portion of plastics sheet.
  • the plastics material of the base member and/or the lid member is pre-coated with the adhesive.
  • the thickness of the coating is at least 15 micrometers.
  • the adhesive is preferably a hot melt adhesive which may include a polyester resin.
  • the hot melt adhesive may be a single component, solvent- borne formulation based on the polyester resin.
  • the resin may a thermoplastic, high molecular weight, saturated polyester.
  • the polyester resin may be a flexible amorphous polymer, which preferably has slight tackiness at room temperature, high elongation and moderate tensile strength.
  • the adhesive may be a heat sealable plastic film, preferably polyethylene.
  • the film is preferably at least 40 micrometers thick.
  • the polyethylene film may be a food-grade film.
  • a method of sealing a monitored dosage apparatus including the steps of: bringing an inner face of the lid member into contact with a top face of the base member; and applying heat and pressure to melt the adhesive and to push the lid member and the base member into firm contact with one another to seal the two members together.
  • a pressure of up to about 501b/sq inch, and preferably 301b/sq inch is applied.
  • a sealed monitored dosage apparatus including: a base member including a plastics sheet having a plurality of formations therein, each providing an open-topped receptacle for receiving medication; a lid member including a plastics sheet sealed to the base member to close and seal the receptacles, the seal being formed by an adhesive; and means for selectively opening individual sealed receptacles, to release the medication contained therein.
  • the adhesive may be applied all over the top face of the base member or may be applied to selected areas only.
  • the adhesive may be applied all over the inner face of the lid member or may be applied to selected areas only.
  • Fig. 1 is a diagrammatic plan view of a monitored dosage apparatus according to the invention in an open position before sealing, viewed from the inside;
  • Fig. 2 is a side view of the monitored dosage apparatus of Fig. 1;
  • Fig. 3 is a diagrammatic plan view of the monitored dosage apparatus of Figs. 1 and 2, in the closed position;
  • Fig. 4 is a diagrammatic side view of the monitored dosage apparatus of Fig. 3.
  • a monitored dosage apparatus 10 includes a base 12 and a lid 14.
  • the base 12 includes a sheet of polypropylene provided with a plurality of formations, which create open-topped pockets 16, protruding down from a generally planar part 18.
  • the pockets 16 are generally cuboid in shape and, when the pack is in its open position as illustrated in Figs. 1 and 2, their open tops allow medication to be placed therein, as described in more detail below.
  • Each pocket 16 is about 25mm in length, 15mm in width and 10mm in depth and there are twenty eight pockets provided in the base 12.
  • the base 12 is made of polypropylene which is about 300 micrometers thick.
  • the lid 14 is also made of polypropylene and is formed as a unitary component with the base 12, a plastics hinge 20 being provided therebetween.
  • the lid 14 comprises a sheet of polypropylene which again is about 300 micrometers thick.
  • the lid 14 is provided with twenty eight widows 22 which, when the lid is hinged into contact with the base 12, cover the open tops of the pockets 16.
  • Each window 22 is defined by a weakened portion 24 in the plastics material of the lid 14, each weakened portion defining a perimeter of its respective window 22.
  • the weakened portion 24 is formed by partially cutting through the plastics sheet of the lid 14.
  • Attached to each window 22 is a release tab 26, manipulation of which allows the weakened portion 24 to be broken and the window 22 to be removed from the remainder of the lid 14.
  • a top face of the generally planar part 18 of the base 12 is pre-coated with a hot melt adhesive.
  • a suitable adhesive is Bostik Estersol 5309 which is a single component, solvent-borne formulation based on polyester resin.
  • the resin is a thermoplastic, high molecular weight, saturated polyester which is a flexible amorphous polymer, very slight tacky at room temperature, with high elongation and moderate tensile strength.
  • the coating may be about 15 to 20 micrometers thick.
  • An inner face of the lid 14 is also pre-coated with hot melt adhesive.
  • the monitored dosage apparatus is used as follows. With the apparatus in the open position illustrated in Figs. 1 and 2, a pharmacist de-blisters the relevant medication for the patient in question and places the medication for each day of a four week period into the appropriate pocket 16.
  • the lid 14 is then pivoted about the hinge 20 to bring its inner face into contact with the top face of the base 12. Temperature and pressure is then applied to melt the adhesive and force the lid 14 and the base 12 into contact with one another thereby adhering the two to each other.
  • a known heat sealing apparatus may be used, which applies temperatures of about 160°C and pressures of about 301b/sq inch.
  • each individual pocket 16 forms a sealed container (see Figs. 3 and 4).
  • the monitored dosage apparatus may then be provided to the nurse or carer who is to dose the patient.
  • the appropriate pocket may be opened by manipulating its release tab 26 and pulling, causing the weakened portion 24 to break and allowing the window 22 to be released from the remainder of the lid 14. This opens the individual pocket 16 allowing the medication to be released therefrom.
  • the apparatus of the invention tends to have a much lower moisture transmission than the prior art and may be classified as Grade A moisture transmission, i.e. less than 0.5 g/m 2 per day.
  • Grade A moisture transmission i.e. less than 0.5 g/m 2 per day.
  • the apparatus allows tamper evident opening of individual pockets.
  • an alternative adhesive could be used to pre-coat the base 12.
  • a polyethylene film which is heat sealable, could be used.
  • the film may be about 40 to 50 micrometers thick.
  • a suitable film would be 40 micron LP8 which is a natural, three layer co-extruded film from British Polythene Limited.
  • the lid 14 and the base 12 may be formed as separate units.
  • the shape of the pockets 16 may be altered as may the system for releasing the education from the pockets.
  • a thin polypropylene film could form the lid and the film could be perforated by thumb pressure in order to release the medication from the pockets.
  • the preferred plastics material for both the lid and the base is polypropylene, between 150 and 300 micrometers thick and having a density of about 0.9 g/cm 3 . This has a tensile strength of at least 30N/mm 2 and a permeability of less than 0.4 g/m 2 per day. However, alternative plastics materials may be used.
  • the polypropylene preferably has a 40 micrometer thick polyethylene laminated to it, to act as a hot melt adhesive. It may only be necessary to coat or laminate one side of the polypropylene but for convenience in a one piece pack both can be coated.
  • the pack may be pre-printed with appropriate information or advertising and because it may be produced in one piece with one pass through a thermoforming or cold forming machine, it can be printed conveniently in short runs.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)

Abstract

L'invention concerne un dispositif de dosage contrôlé (10) comprenant un élément de base (12) comportant une feuille de plastique dans laquelle sont formés des réceptacles (16) ouverts à leur sommet, pouvant contenir un médicament. Ce dispositif (10) comprend également un couvercle (14) comportant une feuille en plastique destinée à être fixée sur l'élément de base (12) pour fermer les réceptacles (16) de manière étanche, le joint étant formé à l'aide d'un adhésif. Le dispositif (10) comprend également un moyen (24, 26) permettant d'ouvrir sélectivement chaque réceptacle pour libérer le médicament.
EP02777502A 2002-11-11 2002-11-11 Plaquette alveolaire Withdrawn EP1565387A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2002/005069 WO2004043823A1 (fr) 2002-11-11 2002-11-11 Plaquette alveolaire

Publications (1)

Publication Number Publication Date
EP1565387A1 true EP1565387A1 (fr) 2005-08-24

Family

ID=32310050

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02777502A Withdrawn EP1565387A1 (fr) 2002-11-11 2002-11-11 Plaquette alveolaire

Country Status (3)

Country Link
EP (1) EP1565387A1 (fr)
AU (1) AU2002339125A1 (fr)
WO (1) WO2004043823A1 (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8303600D0 (en) * 1983-02-09 1983-03-16 Wiggins Teape Group Ltd Blister sheet
CH688372A5 (de) * 1994-12-08 1997-08-29 Alusuisse Lonza Services Ag Blisterpackung.
WO1997010159A1 (fr) * 1995-09-13 1997-03-20 Dai Nippon Printing Co., Ltd. Emballage, son procede de fabrication et combinaison d'un dispositif d'emballage et d'une boite de stockage
EP0838409A1 (fr) * 1996-09-03 1998-04-29 Ricardo Enrique Maclen Feuilles combinables pour l'emballage de tablettes et capsules
EP0860271A1 (fr) * 1997-02-19 1998-08-26 Fujimori Kogyo Co., Ltd. Feuille pour matériau d'emballage
DK1057743T3 (da) * 1997-10-02 2006-03-06 Kyowa Hakko Kogyo Kk Blisterpakning og fremgangsmåde til at udtage og at opdele tabletter
EP0959020A1 (fr) * 1998-05-20 1999-11-24 Alusuisse Technology & Management AG Emballage permettant la sécurité lors de manipulations
EP1157682A1 (fr) * 2000-05-25 2001-11-28 Cilag AG Emballage blister pour comprimés de topiramate
JP3935677B2 (ja) * 2001-01-30 2007-06-27 大和グラビヤ株式会社 包装体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2004043823A1 *

Also Published As

Publication number Publication date
WO2004043823A1 (fr) 2004-05-27
AU2002339125A1 (en) 2004-06-03

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20050608

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SINGULAR PRODUCTS LIMITED

17Q First examination report despatched

Effective date: 20091216

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20100427