EP1551450A4 - Markers of blood barrier permeability and methods of using same - Google Patents

Markers of blood barrier permeability and methods of using same

Info

Publication number
EP1551450A4
EP1551450A4 EP03816193A EP03816193A EP1551450A4 EP 1551450 A4 EP1551450 A4 EP 1551450A4 EP 03816193 A EP03816193 A EP 03816193A EP 03816193 A EP03816193 A EP 03816193A EP 1551450 A4 EP1551450 A4 EP 1551450A4
Authority
EP
European Patent Office
Prior art keywords
markers
methods
same
barrier permeability
blood barrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP03816193A
Other languages
German (de)
French (fr)
Other versions
EP1551450A1 (en
Inventor
Damir Janigro
Nicola Marchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cleveland Clinic Foundation
Original Assignee
Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation filed Critical Cleveland Clinic Foundation
Publication of EP1551450A1 publication Critical patent/EP1551450A1/en
Publication of EP1551450A4 publication Critical patent/EP1551450A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP03816193A 2002-06-12 2003-06-12 Markers of blood barrier permeability and methods of using same Ceased EP1551450A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38837102P 2002-06-12 2002-06-12
US388371P 2002-06-12
PCT/US2003/018780 WO2004078204A1 (en) 2002-06-12 2003-06-12 Markers of blood barrier permeability and methods of using same

Publications (2)

Publication Number Publication Date
EP1551450A1 EP1551450A1 (en) 2005-07-13
EP1551450A4 true EP1551450A4 (en) 2005-11-23

Family

ID=32962110

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03816193A Ceased EP1551450A4 (en) 2002-06-12 2003-06-12 Markers of blood barrier permeability and methods of using same

Country Status (3)

Country Link
EP (1) EP1551450A4 (en)
AU (1) AU2003243563A1 (en)
WO (1) WO2004078204A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1519194A1 (en) 2003-09-24 2005-03-30 Roche Diagnostics GmbH Use of gfap for identification of intracerebral hemorrhage
US8492107B2 (en) 2004-04-15 2013-07-23 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
WO2010019553A2 (en) 2008-08-11 2010-02-18 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
WO2010030203A1 (en) * 2008-09-09 2010-03-18 Biocodex - Incubação De Empresas De Ciências Da Vida, S.A. Monoclonal antibody to human amyloidogenic and modified forms of transthyretin and its use in the detection and treatment of fap and pathologies presenting modified ttr
EP2478360B1 (en) 2009-09-14 2018-06-27 Banyan Biomarkers, Inc. Autoantibody markers for diagnosis of traumatic brain injury

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268223B1 (en) * 1999-08-27 2001-07-31 Viatech Imagin, Llc Assay for detecting damage to the central nervous system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268223B1 (en) * 1999-08-27 2001-07-31 Viatech Imagin, Llc Assay for detecting damage to the central nervous system

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HAMILTON J A ET AL: "Transthyretin: A review from a structural perspective", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 58, no. 10, September 2001 (2001-09-01), pages 1491 - 1521, XP009054580, ISSN: 1420-682X *
HIRAOKA A ET AL: "Sodium dodecylsulfate capillary gel electrophoretic measurement of the concentration ratios of albumin and alpha2-macroglobulin in cerebrospinal fluid and serum of patients with neurological disorders", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 895, no. 1-2, 20 October 2000 (2000-10-20), pages 339 - 344, XP004217511, ISSN: 0021-9673 *
JANIGRO D ET AL: "MARKERS OF BBB DAMAGE AND INFLAMMATORY PROCESS.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 580.9 URL, XP009054609 *
See also references of WO2004078204A1 *

Also Published As

Publication number Publication date
AU2003243563A1 (en) 2004-09-28
EP1551450A1 (en) 2005-07-13
WO2004078204A1 (en) 2004-09-16

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20050105

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

A4 Supplementary search report drawn up and despatched

Effective date: 20051007

17Q First examination report despatched

Effective date: 20060410

STAA Information on the status of an ep patent application or granted ep patent

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18R Application refused

Effective date: 20081116