EP1551383A4 - Methods for preventing and treating microbial infections by modulating transcription factors - Google Patents

Methods for preventing and treating microbial infections by modulating transcription factors

Info

Publication number
EP1551383A4
EP1551383A4 EP03742158A EP03742158A EP1551383A4 EP 1551383 A4 EP1551383 A4 EP 1551383A4 EP 03742158 A EP03742158 A EP 03742158A EP 03742158 A EP03742158 A EP 03742158A EP 1551383 A4 EP1551383 A4 EP 1551383A4
Authority
EP
European Patent Office
Prior art keywords
preventing
methods
transcription factors
microbial infections
treating microbial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03742158A
Other languages
German (de)
French (fr)
Other versions
EP1551383A2 (en
Inventor
Michael N Alekshun
Stuart B Levy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Priority to EP12158058.3A priority Critical patent/EP2586440A2/en
Publication of EP1551383A2 publication Critical patent/EP1551383A2/en
Publication of EP1551383A4 publication Critical patent/EP1551383A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
EP03742158A 2002-06-24 2003-06-24 Methods for preventing and treating microbial infections by modulating transcription factors Withdrawn EP1551383A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12158058.3A EP2586440A2 (en) 2002-06-24 2003-06-24 Methods for preventing and treating microbial infections by modulating transcription factors

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US39134502P 2002-06-24 2002-06-24
US391345P 2002-06-24
US42121802P 2002-10-25 2002-10-25
US421218P 2002-10-25
US42914202P 2002-11-26 2002-11-26
US429142P 2002-11-26
US45893503P 2003-03-31 2003-03-31
US458935P 2003-03-31
PCT/US2003/019831 WO2004000228A2 (en) 2002-06-24 2003-06-24 Methods for preventing and treating microbial infections by modulating transcription factors

Publications (2)

Publication Number Publication Date
EP1551383A2 EP1551383A2 (en) 2005-07-13
EP1551383A4 true EP1551383A4 (en) 2007-12-05

Family

ID=30003984

Family Applications (2)

Application Number Title Priority Date Filing Date
EP12158058.3A Withdrawn EP2586440A2 (en) 2002-06-24 2003-06-24 Methods for preventing and treating microbial infections by modulating transcription factors
EP03742158A Withdrawn EP1551383A4 (en) 2002-06-24 2003-06-24 Methods for preventing and treating microbial infections by modulating transcription factors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP12158058.3A Withdrawn EP2586440A2 (en) 2002-06-24 2003-06-24 Methods for preventing and treating microbial infections by modulating transcription factors

Country Status (5)

Country Link
EP (2) EP2586440A2 (en)
JP (3) JP2006504677A (en)
AU (2) AU2003279273B2 (en)
CA (1) CA2489943A1 (en)
WO (1) WO2004000228A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2507733A4 (en) * 2009-12-02 2017-01-25 Zymeworks Inc. Combined on-lattice/off-lattice optimization method for rigid body docking
WO2014059313A1 (en) * 2012-10-12 2014-04-17 Lehigh University Thermally stable enzymes, compositions thereof and methods of using same
CN111166743B (en) * 2020-01-02 2022-03-22 中国医学科学院医药生物技术研究所 Anti-infection application of thiazole structure-containing compound

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3830697A1 (en) * 1988-09-09 1990-03-22 Knoll Ag Substituted phenylacetonitriles for use for breaking resistance
JPH0826991A (en) * 1994-07-14 1996-01-30 Kureha Chem Ind Co Ltd Sensitizer for medicine sensitivity of antibiotic-resistant microorganism
WO1998006837A1 (en) * 1996-08-16 1998-02-19 Yale University Phenotypic conversion of drug-resistant bacteria to drug-sensitivity
WO1998037188A1 (en) * 1997-02-21 1998-08-27 Hybridon, Inc. OLIGONUCLEOTIDES SPECIFIC FOR THE marORAB OPERON
US5817793A (en) * 1992-08-28 1998-10-06 Trustees Of Tufts College Multiple antibiotic resistance operon assays
WO2000052144A1 (en) * 1999-03-03 2000-09-08 Board Of Regents, The University Of Texas System Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors
WO2004001058A2 (en) * 2001-05-04 2003-12-31 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4745056A (en) 1984-10-23 1988-05-17 Biotechnica International, Inc. Streptomyces secretion vector
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4820639A (en) 1985-12-04 1989-04-11 Massachusetts Institute Of Technology Process for enhancing translational efficiency of eukaryotic mRNA
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5270181A (en) 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
US5292646A (en) 1991-02-06 1994-03-08 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
US5491084A (en) 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US5563036A (en) * 1994-04-29 1996-10-08 Tularik, Inc. Transcription factor-DNA binding assay
ES2170220T3 (en) 1995-01-31 2002-08-01 Bioimage As PROCEDURE TO DETECT BIOLOGICALLY ACTIVE SUBSTANCES.
US5679364A (en) 1995-06-07 1997-10-21 Lee County Mosquito Control District Compositions and methods for reducing the amount of contaminants in aquatic and terrestrial environments
US6057367A (en) * 1996-08-30 2000-05-02 Duke University Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses
EP1080232A2 (en) 1998-05-22 2001-03-07 Tufts University MarA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3830697A1 (en) * 1988-09-09 1990-03-22 Knoll Ag Substituted phenylacetonitriles for use for breaking resistance
US5817793A (en) * 1992-08-28 1998-10-06 Trustees Of Tufts College Multiple antibiotic resistance operon assays
JPH0826991A (en) * 1994-07-14 1996-01-30 Kureha Chem Ind Co Ltd Sensitizer for medicine sensitivity of antibiotic-resistant microorganism
WO1998006837A1 (en) * 1996-08-16 1998-02-19 Yale University Phenotypic conversion of drug-resistant bacteria to drug-sensitivity
WO1998037188A1 (en) * 1997-02-21 1998-08-27 Hybridon, Inc. OLIGONUCLEOTIDES SPECIFIC FOR THE marORAB OPERON
WO2000052144A1 (en) * 1999-03-03 2000-09-08 Board Of Regents, The University Of Texas System Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors
WO2004001058A2 (en) * 2001-05-04 2003-12-31 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof

Also Published As

Publication number Publication date
AU2003279273A1 (en) 2004-01-06
JP2009280591A (en) 2009-12-03
AU2003279273B2 (en) 2009-10-01
AU2009213078A1 (en) 2009-10-08
JP2006504677A (en) 2006-02-09
WO2004000228A3 (en) 2004-10-28
AU2009213078C1 (en) 2013-01-17
AU2009213078B2 (en) 2012-01-19
CA2489943A1 (en) 2003-12-31
JP2012214493A (en) 2012-11-08
EP1551383A2 (en) 2005-07-13
EP2586440A2 (en) 2013-05-01
WO2004000228A2 (en) 2003-12-31

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Effective date: 20071107

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/555 20060101ALI20071031BHEP

Ipc: A61K 31/54 20060101ALI20071031BHEP

Ipc: A61K 31/41 20060101ALI20071031BHEP

Ipc: A61K 31/38 20060101ALI20071031BHEP

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Effective date: 20140103