EP1540012A4 - Polymorphisms for predicting disease and treatment outcome - Google Patents

Polymorphisms for predicting disease and treatment outcome

Info

Publication number
EP1540012A4
EP1540012A4 EP03772163A EP03772163A EP1540012A4 EP 1540012 A4 EP1540012 A4 EP 1540012A4 EP 03772163 A EP03772163 A EP 03772163A EP 03772163 A EP03772163 A EP 03772163A EP 1540012 A4 EP1540012 A4 EP 1540012A4
Authority
EP
European Patent Office
Prior art keywords
polymorphisms
treatment outcome
predicting disease
predicting
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03772163A
Other languages
German (de)
French (fr)
Other versions
EP1540012A2 (en
Inventor
Heinz-Josef Lenz
Jan Stoehlmacher
David Jong-Han Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Southern California USC filed Critical University of Southern California USC
Priority to EP10184531A priority Critical patent/EP2385139A1/en
Priority to EP10184438A priority patent/EP2385137A1/en
Priority to EP10184512A priority patent/EP2385138A1/en
Publication of EP1540012A2 publication Critical patent/EP1540012A2/en
Publication of EP1540012A4 publication Critical patent/EP1540012A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP03772163A 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome Withdrawn EP1540012A4 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10184531A EP2385139A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome
EP10184438A EP2385137A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome
EP10184512A EP2385138A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40025002P 2002-07-31 2002-07-31
US40027602P 2002-07-31 2002-07-31
US40024902P 2002-07-31 2002-07-31
US40025302P 2002-07-31 2002-07-31
US400249P 2002-07-31
US400250P 2002-07-31
US400276P 2002-07-31
US400253P 2002-07-31
PCT/US2003/024065 WO2004011625A2 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome

Publications (2)

Publication Number Publication Date
EP1540012A2 EP1540012A2 (en) 2005-06-15
EP1540012A4 true EP1540012A4 (en) 2006-03-22

Family

ID=31192379

Family Applications (4)

Application Number Title Priority Date Filing Date
EP10184438A Withdrawn EP2385137A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome
EP03772163A Withdrawn EP1540012A4 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome
EP10184531A Withdrawn EP2385139A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome
EP10184512A Withdrawn EP2385138A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10184438A Withdrawn EP2385137A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP10184531A Withdrawn EP2385139A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome
EP10184512A Withdrawn EP2385138A1 (en) 2002-07-31 2003-07-31 Polymorphisms for predicting disease and treatment outcome

Country Status (6)

Country Link
US (4) US7662553B2 (en)
EP (4) EP2385137A1 (en)
JP (1) JP2005534686A (en)
AU (1) AU2003257110A1 (en)
CA (1) CA2494262A1 (en)
WO (1) WO2004011625A2 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036686A2 (en) * 1999-11-15 2001-05-25 University Of Southern California Genomic polymorphism for predicting therapeutic response
AU2002241911B9 (en) 2001-01-19 2007-01-25 Celmed Oncology (Usa), Inc. Methods to treat autoimmune and inflammatory conditions
AU2003257110A1 (en) 2002-07-31 2004-02-16 University Of Southern California Polymorphisms for predicting disease and treatment outcome
US20050014165A1 (en) * 2003-07-18 2005-01-20 California Pacific Medical Center Biomarker panel for colorectal cancer
EP1730306A2 (en) * 2004-03-01 2006-12-13 University of Chicago Polymorphisms in the epidermal growth factor receptor gene promoter
EP1781809A1 (en) * 2004-04-08 2007-05-09 BRAUCH, Hiltrud Ercc2 polymorphisms
US20060115827A1 (en) * 2004-07-01 2006-06-01 University Of Southern California Genetic markers for predicting disease and treatment outcome
GB2424886A (en) 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
EP1960549A4 (en) * 2005-11-30 2010-01-13 Univ Southern California Fc polymorphisms for predicting disease and treatment outcome
EP1991268A4 (en) * 2006-03-03 2009-08-26 Univ Southern California Angiogenesis pathway gene polymorphisms for therapy selection
US20070218487A1 (en) * 2006-03-03 2007-09-20 University Of Southern California Genetic markers for predicting disease and treatment outcome
EP1991707A4 (en) * 2006-03-03 2012-11-21 Univ Southern California Polymorphisms in voltage-gated sodium channel alpha 1-subunit as markers for therapy selection
WO2007114896A2 (en) 2006-03-31 2007-10-11 Ordway Research Institute Prognostic and diagnostic method for cancer therapy
EP2059615A2 (en) * 2006-08-17 2009-05-20 Ordway Research Institute, Inc. Prognostic and diagnostic method for disease therapy
FR2906532B1 (en) * 2006-09-28 2008-12-12 Biomerieux Sa NEW OLIGONUCLEOTIDE BRAND
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
WO2008088860A2 (en) 2007-01-18 2008-07-24 University Of Southern California Polymorphisms in the egfr pathway as markers for cancer treatment
WO2008088861A2 (en) 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms predictive for dual tki therapy
AU2008205544A1 (en) * 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms as predictors of tumor progression and their use in cancer therapy
WO2008089465A2 (en) * 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms as sex-specific predictors in cancer therapy
EP2155908A4 (en) * 2007-05-18 2010-12-01 Univ Southern California Germline polymorphisms in the angiogenic pathway predict tumor recurrence in cancer therapy
WO2009009776A2 (en) * 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Patient selection and therapeutic methods using markers of prostaglandin metabolism
EP2170062A4 (en) 2007-07-12 2010-12-29 Tragara Pharmaceuticals Inc Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
DE102007036404A1 (en) * 2007-07-27 2009-01-29 Eberhard-Karls-Universität Tübingen Universitätsklinikum Detection of platinum resistance
WO2009113989A1 (en) * 2008-03-14 2009-09-17 Bionumerik Pharmaceuticals, Inc. Compositions and methods of use of compounds to increase cancer patient survival time
EP2283148A4 (en) * 2008-04-25 2011-11-30 Integrated Bioscience Solutions Llc Cytological methods for detecting cancer
CA2724346A1 (en) * 2008-05-15 2009-11-19 University Of Southern California Ercc-1 expression predicts chemotherapy outcome
EP2806054A1 (en) 2008-05-28 2014-11-26 Genomedx Biosciences Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
GB2467691A (en) 2008-09-05 2010-08-11 Aueon Inc Methods for stratifying and annotating cancer drug treatment options
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
CN104523661A (en) 2009-02-06 2015-04-22 南加利福尼亚大学 Therapeutic compositions comprising monoterpenes
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
US8568968B2 (en) * 2009-04-13 2013-10-29 University Of Southern California EGFR polymorphisms predict gender-related treatment
WO2010124239A2 (en) * 2009-04-24 2010-10-28 University Of Southern California Genetic polymorphisms associated with clinical outcomes of topoisomerase inhibitor therapy for cancer
WO2010129934A2 (en) 2009-05-07 2010-11-11 Veracyte, Inc. Methods and compositions for diagnosis of thyroid conditions
EP2311977A1 (en) * 2009-10-15 2011-04-20 INSERM (Institut National de la Santé et de la Recherche Medicale) Method for predicting responsiveness of a patient to a chemoradiation treatment
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
US10513737B2 (en) 2011-12-13 2019-12-24 Decipher Biosciences, Inc. Cancer diagnostics using non-coding transcripts
DK3435084T3 (en) 2012-08-16 2023-05-30 Mayo Found Medical Education & Res PROSTATE CANCER PROGNOSIS USING BIOMARKERS
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
EP3770274A1 (en) 2014-11-05 2021-01-27 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
EP3504348B1 (en) 2016-08-24 2022-12-14 Decipher Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
US11873532B2 (en) 2017-03-09 2024-01-16 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
WO2018205035A1 (en) 2017-05-12 2018-11-15 Genomedx Biosciences, Inc Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
RU2732336C1 (en) * 2020-01-14 2020-09-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Method for predicting effectiveness of neoadjuvant chemoradiotherapy in rectal adenocarcinoma

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036686A2 (en) * 1999-11-15 2001-05-25 University Of Southern California Genomic polymorphism for predicting therapeutic response
WO2004037852A2 (en) * 2002-10-21 2004-05-06 University Of Medicine And Dentistry Of New Jersey Thymidylate synthase polymorphisms for use in screening for cancer susceptibility

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4998617A (en) 1986-09-15 1991-03-12 Laura Lupton Inc Facial cosmetic liquid make up kit
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5256775A (en) 1989-06-05 1993-10-26 Gilead Sciences, Inc. Exonuclease-resistant oligonucleotides
FR2650840B1 (en) 1989-08-11 1991-11-29 Bertin & Cie RAPID DETECTION AND / OR IDENTIFICATION OF A SINGLE BASED ON A NUCLEIC ACID SEQUENCE, AND ITS APPLICATIONS
US5264564A (en) 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
EP0500727B1 (en) 1989-11-13 1998-01-21 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal dna
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
DE69322266T2 (en) 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. SAMPLES COMPOSITION AND METHOD
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5547835A (en) 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
AU687801B2 (en) 1993-03-19 1998-03-05 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US5593826A (en) 1993-03-22 1997-01-14 Perkin-Elmer Corporation, Applied Biosystems, Inc. Enzymatic ligation of 3'amino-substituted oligonucleotides
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5705336A (en) * 1995-03-07 1998-01-06 The United States Of America As Represented By The Department Of Health And Human Services Assay for sensitivity of tumors to DNA-platinating chemotherapy
US5571676A (en) 1995-06-07 1996-11-05 Ig Laboratories, Inc. Method for mismatch-directed in vitro DNA sequencing
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
WO1997046715A1 (en) 1996-06-03 1997-12-11 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Fc receptor polymorphism
US6248535B1 (en) 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
US6716581B2 (en) 2000-03-31 2004-04-06 University Of Southern California Manganese superoxide dismutase gene polymorphism for predicting cancer susceptibility
US7049059B2 (en) 2000-12-01 2006-05-23 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression
US6518416B1 (en) 2000-12-01 2003-02-11 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 expression
US6602670B2 (en) 2000-12-01 2003-08-05 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 expression
US20040265813A1 (en) 2001-07-05 2004-12-30 Teiji Takechi Dna arrays for measuring sensitivity to anticancer agent
DE02782887T1 (en) 2001-10-19 2005-01-13 Centre Hospitalier Regional et Universitair de Tours METHODS AND COMPOSITIONS TO EVALUATE ANTIBODY TREATMENT
AU2003257110A1 (en) 2002-07-31 2004-02-16 University Of Southern California Polymorphisms for predicting disease and treatment outcome
EP1584691A1 (en) * 2003-01-10 2005-10-12 Fundacion para la Investigacion Clinica y Molecular del Cancer de Pulmon Device for assaying polymorphisms of gene xpd/ercc2 for the correct administration of chemotherapy for lung cancer
US9109255B2 (en) 2004-06-18 2015-08-18 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining responsiveness to antibody therapy
US20060115827A1 (en) 2004-07-01 2006-06-01 University Of Southern California Genetic markers for predicting disease and treatment outcome
EP1960549A4 (en) 2005-11-30 2010-01-13 Univ Southern California Fc polymorphisms for predicting disease and treatment outcome
US20070218487A1 (en) 2006-03-03 2007-09-20 University Of Southern California Genetic markers for predicting disease and treatment outcome
EP1991707A4 (en) 2006-03-03 2012-11-21 Univ Southern California Polymorphisms in voltage-gated sodium channel alpha 1-subunit as markers for therapy selection
EP1991268A4 (en) 2006-03-03 2009-08-26 Univ Southern California Angiogenesis pathway gene polymorphisms for therapy selection
AU2008205544A1 (en) 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms as predictors of tumor progression and their use in cancer therapy
CA2675305A1 (en) 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms in vegf and vegf receptor 2 as markers for cancer therapy
WO2008089465A2 (en) 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms as sex-specific predictors in cancer therapy
EP2109686A2 (en) 2007-01-18 2009-10-21 University Of Southern California Genetic markers for predicting responsiveness to combination therapy
WO2008088860A2 (en) 2007-01-18 2008-07-24 University Of Southern California Polymorphisms in the egfr pathway as markers for cancer treatment
WO2008088861A2 (en) 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms predictive for dual tki therapy
EP2132328A2 (en) 2007-01-18 2009-12-16 University Of Southern California Tissue factor promoter polymorphisms
US9031642B2 (en) 2013-02-21 2015-05-12 Medtronic, Inc. Methods for simultaneous cardiac substrate mapping using spatial correlation maps between neighboring unipolar electrograms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036686A2 (en) * 1999-11-15 2001-05-25 University Of Southern California Genomic polymorphism for predicting therapeutic response
WO2004037852A2 (en) * 2002-10-21 2004-05-06 University Of Medicine And Dentistry Of New Jersey Thymidylate synthase polymorphisms for use in screening for cancer susceptibility

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
FOX S H ET AL: "Angiogenesis in normal tissue adjacent to colon cancer.", JOURNAL OF SURGICAL ONCOLOGY. DEC 1998, vol. 69, no. 4, December 1998 (1998-12-01), pages 230 - 234, XP002362465, ISSN: 0022-4790 *
IACOPETTA B ET AL: "A POLYMORPHISM IN THE ENHANCER REGION OF THE THYMIDYLATE SYNTHASE PROMOTER INFLUENCES THE SURVIVAL OF COLORECTAL CANCER PATIENTS TREATED WITH 5-FLUOROURACIL", BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 85, no. 6, 14 September 2001 (2001-09-14), pages 827 - 830, XP001199503, ISSN: 0007-0920 *
KUNIYASU H ET AL: "Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer.", AMERICAN JOURNAL OF PATHOLOGY. NOV 2000, vol. 157, no. 5, November 2000 (2000-11-01), pages 1523 - 1535, XP002362464, ISSN: 0002-9440 *
LENZ HEINZ-JOSEF ET AL: "A 6 base-pair deletion in the 3 UTR of the thymidylate synthase (TS) gene predicts TS mRNA expression in colorectal tumors: A possible candidate gene for colorectal cancer risk", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 43, March 2002 (2002-03-01), & 93RD ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; SAN FRANCISCO, CALIFORNIA, USA; APRIL 06-10, 2002, pages 660, XP001207619, ISSN: 0197-016X *
LIOTTA L A ET AL: "The microenvironment of the tumour-host interface.", NATURE. 17 MAY 2001, vol. 411, no. 6835, 17 May 2001 (2001-05-17), pages 375 - 379, XP002362466, ISSN: 0028-0836 *
PARK DAVID J ET AL: "Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer", INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, vol. 17, no. 1, January 2002 (2002-01-01), pages 46 - 49, XP002347623, ISSN: 0179-1958 *
PULLARKAT S ET AL: "THYMIDYLATE SYNTHASE GENE POLYMORPHISM DETERMINES RESPONSE AND TOXICITY OF 5-FU CHEMOTHERAPY", PHARMACOGENOMICS JOURNAL, NATURE PUBLISHING GROUP, GB, vol. 1, no. 1, 2001, pages 65 - 70, XP001013686, ISSN: 1470-269X *
SHIROTA Y ET AL: "ERCC1 AND THYMIDYLATE SYNTHASE MRNA LEVELS PREDICT SURVIVAL FOR COLORECTAL CANCER PATIENTS RECEIVING COMBINATION OXALIPLATIN AND FLUOROURACIL CHEMOTHERAPY", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 19, no. 23, 1 December 2001 (2001-12-01), pages 4298 - 4304, XP009002481, ISSN: 0732-183X *
ULRICH ET AL: "Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene", CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION, AMERICAN ASSOCIATION FOR CANCER RESEARCH,, US, vol. 9, no. 12, December 2000 (2000-12-01), pages 1381 - 1385, XP002979555, ISSN: 1055-9965 *
VILLAFRANCA E ET AL: "POLYMORPHISMS OF THE REPEATED SEQUENCES IN THE ENHANCER REGION OF THE THYMIDYLATE SYNTHASE GENE PROMOTER MAY PREDICT DOWNSTAGING AFTER PREOPERATIVE CHEMORADIATION IN RECTAL CANCER", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 19, no. 6, 15 March 2001 (2001-03-15), pages 1779 - 1786, XP008033687, ISSN: 0732-183X *

Also Published As

Publication number Publication date
US7662553B2 (en) 2010-02-16
US20100173922A1 (en) 2010-07-08
EP2385138A1 (en) 2011-11-09
EP2385139A1 (en) 2011-11-09
US20130196955A1 (en) 2013-08-01
US20120122946A1 (en) 2012-05-17
AU2003257110A8 (en) 2004-02-16
AU2003257110A1 (en) 2004-02-16
EP2385137A1 (en) 2011-11-09
CA2494262A1 (en) 2004-02-05
EP1540012A2 (en) 2005-06-15
US20060094012A1 (en) 2006-05-04
JP2005534686A (en) 2005-11-17
WO2004011625A3 (en) 2004-11-11
WO2004011625A2 (en) 2004-02-05

Similar Documents

Publication Publication Date Title
AU2003257110A8 (en) Polymorphisms for predicting disease and treatment outcome
EP1774039A4 (en) Genetic markers for predicting disease and treatment outcome
GB0201850D0 (en) Therapeutic treatment
GB0216321D0 (en) Therapeutic treatment
AU2003290548A8 (en) Prevention and treatment of synucleinopathic disease
IL165575A0 (en) System for treating obesity and implant therefor
EP1960549A4 (en) Fc polymorphisms for predicting disease and treatment outcome
AU2002325435A8 (en) Medication and method for treating pathological syndrome
HK1078784A1 (en) Therapeutic treatment
EP1567198A4 (en) Materials and methods for treating ocular-related disorders
AU2003266291A8 (en) Single nucleotide polymorphisms predicting adverse drug reactions and drug efficacy in cardiovascular disease
GB0223367D0 (en) Therapeutic treatment
IL165242A0 (en) Treatment for diabetes
GB2388557B (en) Treatment system
EP1576109A4 (en) Methods and compositions for categorizing patients
AU2003223780A8 (en) Treatment for pompe disease
GB0210464D0 (en) Therapeutic treatment
AU2003301348A8 (en) Compositions and methods for diagnosing and treating autoimmune disease
AU2003277202A8 (en) Methods for diagnosing bone turnover disease
AU2003201159A8 (en) Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy
GB2385333B (en) Plate treatment
EP1569928A4 (en) Therapeutic compounds and methods
AU2003248679A8 (en) Treating disease using radium-225
GB0229139D0 (en) Gene polymorphisms
AU2003297912A8 (en) Methods for screening compounds for use in the treatment of disease

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20050202

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20060203

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PARK, DAVID, (JONG-HAN)

Inventor name: STOEHLMACHER, JAN

Inventor name: LENZ, HEINZ-JOSEF

17Q First examination report despatched

Effective date: 20070821

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110607