Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
  • A61F2/2493—Transmyocardial revascularisation [TMR] devices

Definitions

• the present invention relates to stents for connecting a first compartment to a second compartment.
• the invention relates to cardiovascular stents e.g. for connection of the left ventricle of the heart to a coronary artery.
• Coronary artery disease is. a major problem thoughout the world, particularly in Western society. Coronary arteries, as well as other blood vessels, can become clogged with plaque, impairing the efficiency of the heart's pumping action. This can lead to heart attacks, angina and death.
• a number of methods are used to treat clogged coronary arteries such as bypass operations or balloon angioplasty.
• bypass operations one or more venous segments are inserted between the aorta and the coronary arteries to bypass the blocked portion of the coronary artery such that an unobstructed flow of blood and thus blood supply to the heart is achieved. More than 500,000 bypass procedures are performed in the US every year.
• bypass surgery is a very intrusive procedure requiring expensive and time-consuming surgery.
• an incision is made through the patient's skin and the patient is placed on a bypass pump such that the heart can be operated on, while it is not beating.
• a saphenous vein graft is harvested from a patient's leg and the vein is then grafted into position between the aorta and the coronary artery to allow unobstructed blood flow.
• This surgery is both traumatic to the patient and requires a substantial period of time in hospital and prolonged convalescence.
• a balloon angioplasty procedure is used instead of the above method, to treat coronary artery plaque occlusion.
• a deflated balloon catheter is placed within the narrowed segment of the coronary artery.
• the balloon is then inflated to a high pressure, transmitting circumferential pressure to the plaque occluding the artery, compressing the plaque and thus increasing the diameter through which blood can flow.
• balloon angioplasty is minimally invasive, this procedure can only be used in a limited number of circumstances.
• a more recent procedure allows a stent to be positioned between the coronary artery and the left ventricle of the heart such that blood can flow unobstructed from the left ventricle of the heart to the coronary artery, bypassing the occluded portion of the coronary artery.
• the stent may be positioned between the left ventricle of the heart and the coronary artery using a less invasive procedure than that required for coronary bypass surgery.
• the stent is a conduit with a passage extending longitudinally therethrough.
• a stent is cylindrical in cross section and is generally an elongate tube.
• a disadvantage of providing a stent extending from the left ventricle of the heart to the coronary artery is that during diastole blood may reflux from the coronary artery back into the left ventricle of the heart. Such refluxes of blood are undesirable.
• the present inventor has overcome a number of problems of stents of the prior art.
• a cardiovascular stent comprising a generally tubular body and a synthetic one-way valve capable of moving from a first open position to a second closed position, wherein, in use, movement of fluid, e.g. blood, in a first direction through the stent causes the valve to adopt the open position and movement of fluid in a second opposite direction causes the valve to adopt the closed position.
• fluid e.g. blood
• the valve is deemed to be in the closed position when it restricts the passage of fluid in the second direction e.g. from a second compartment to a first compartment.
• a stent as described by the present invention can be used to enable the movement of fluid from a proximal position in a first cardiovascular compartment to a distal position in the same cardiovascular compartment or a different cardiovascular compartment.
• the valve allows movement of fluid in the second direction of less than 40% that when the valve is in the open position.
• the valve allows movement of fluid in a second direction of less than 30%, preferably less than 20%, even more preferably less than 10%, even more preferably less than 5%, even more preferably less than 2% and most preferably less than 1% that when the valve is in the open position.
• a stent with a synthetic valve is advantageous as it can restrict the passage of fluid in a second direction, e.g. from a second compartment to a first compartment, e.g. from a coronary artery to the left ventricle of the heart.
• This provides for an increase in the net flow rate of blood from the first compartment into the second compartment and minimises the likelihood of e.g. the myocardium, of which the coronary artery provides the blood supply, receiving an inadequate supply of blood.
• the movement of fluid in the first direction e.g. from the first compartment to the second compartment causes a pressure difference across the valve sufficient to cause the valve to adopt the open position.
• Fluid flow in the second opposite direction e.g. from the second compartment to the first compartment across the valve, causes the valve to adopt the closed position.
• valve Preferably in the absence of movement of fluid in either a first or second direction the valve adopts the closed position.
• the valve is resiliently biased towards the closed configuration.
• the stent is for use in linking cardiovascular compartments.
• the first compartment is a first cardiovascular compartment and the second compartment is a second cardiovascular compartment.
• a cardiovascular stent is a stent suitable for use to link one part of a cardiovascular compartment to another part of the same cardiovascular compartment or to another cardiovascular compartment.
• a cardiovascular compartment is defined as any organ or any structure of the circulatory system including an artery, vein or chamber of the heart.
• the stent is for use as a stent between the left ventricle of the heart and a coronary artery.
• valve is formed from resilient material.
• a valve formed from resilient material is advantageous as it requires few mechanical components to enable the valve to move between the open and closed positions and thus there is less likelihood of damage to red blood corpuscles moved through the stent .
• the flexible resilient material is a suitable biostable biocompatible polymer.
• the flexible resilient material includes Elast-EonTM, Biomer or Biospan.
• the valve in the closed position, preferably at least a portion of the aperture formed by the resilient material of the valve is ellipsoidal shape in cross-section. This ellipsoidal shape restricts blood flow from the second cardiovascular compartment into the first cardiovascular compartment.
• the valve is constructed such that movement of fluid such as blood in the first direction through the stent urges the resilient material of the valve to adopt a configuration in which the aperture defined by the material is substantially circular in cross-section thereby enabling increased fluid to flow through the valve and thus through the stent .
• the aperture defined by the material is substantially circular in cross-section thereby enabling increased fluid to flow through the valve and thus through the stent .
• the valve may comprise at least two leaflets formed from resilient material which when fluid is flowing in the second direction through the stent or when no fluid is flowing through the stent, the leaflets are urged towards each other such that the passage of fluid e.g. blood is minimised.
• movement of fluid in the first direction e.g. from a first compartment to a second compartment urges the leaflets of the valve to move apart from each other enabling the passage of fluid through the stent.
• the valve may be located at any position in the stent.
• valve is located at either end of the stent .
• Such an embodiment is advantageous as a valve portion of the stent can extend into a cardiovascular compartment. This can be of importance, for example, if the stent is for use between the left ventricle of the heart and the coronary artery as positioning of the valve in the heart muscle may restrict the movement of the valve, as the muscle contracts and relaxes.
• the valve is integral to the stent .
• valve means provided on the stent
• the stent may be constructed of any suitable material.
• the stent may comprise a suitable rigid biocompatible metal which may include, but is not limited to one or more of stainless steel, spring steel, Nitinol and / or a flexible resilient material.
• the stent may be constructed from scaffold mesh.
• the stent comprises a flange portion located towards or at one end of the stent.
• the depth of the stent in the tissue can be controlled by the flange portion. If, for example, the flange portion is towards or at the rear portion of the stent, the front portion being the portion inserted first into the tissue, on pushing the stent into tissue from one compartment to another the flange provided at the rear will prevent the stent being pushed too far into the tissue, ensuring that the lumen of the stent extends from a first compartment into a second compartment . Moreover the flange portion can also be used to secure the stent in position, the tissue at around the flange preventing movement of the stent from a first compartment to a second compartment .
• the valve comprises at least one cantilever member, having a first end and a second end, said cantilever member being pivoted at said first end to the stent, the cantilever member being resiliently pivotable from a first extended position in which the valve is in a closed position to a second position in which the valve is open.
• the material forming the valve and defining the aperture of the valve when in the open position, is pulled such that the area of the aperture formed by the material is decreased.
• movement of fluid in a first direction through the stent causes the second end of the cantilever member to resiliently move radially inwards towards the central longitudinal axis of the stent.
• This movement of the second end of the cantilever member causes the material forming the valve and defining the aperture of the valve to form a larger aperture (preferably substantially circular) in cross section enabling increased fluid to flow through the valve .
• the cantilever member resiliently pivots to the extended position.
• This movement of the second end of the cantilever member to the extended position causes the material forming the valve and defining the aperture of the valve to be pulled to form an aperture of reduced area in cross section.
• the aperture has less area in cross section than the substantially circular aperture, fluid flow in both the first and second directions is restricted.
• the valve comprises two cantilever members.
• the two cantilever members are resiliently pivoted at first ends of the members to the stent.
• the second ends of the cantilever members pivot radially outwards to an extended position.
• Such an embodiment may function as follows: Movement of fluid in a first direction through the stent causes the second ends of the cantilever members to resiliently move radially inwards towards the central longitudinal axis of the stent . This movement of the second ends of the cantilever members causes the material forming the valve and defining the aperture of the valve to form a substantially circular aperture in cross section enabling blood to flow through the valve.
• the second ends of the cantilever members again resiliently pivot to an extended position.
• the movement of the second ends of the cantilever members to their extended positions again causes the material forming the valve and defining the aperture of the valve to be pulled to form an ellipsoid aperture of reduced area in cross section.
• the aperture has less area in cross section than the substantially circular aperture, fluid flow in both the first and second directions is restricted.
• the aperture formed by the resilient material is preferably pulled from a substantially circular cross section to a substantially ellipsoidal cross section, which, in use, restricts the flow of fluid from a second compartment toward a first compartment.
• the stent is constructed such that it can be expanded in diameter from a "collapsed” configuration to an “expanded” configuration, wherein, in the collapsed configuration, the stent is of narrower diameter that in the expanded configuration.
• Such a structure enables the stent to be suitably placed in the body in the narrowed collapsed configuration and then expanded from its collapsed configuration to a fully expanded configuration.
• the diameter of the stent can be increased from the collapsed to expanded position using any suitable procedures, for example, using a balloon angioplasty procedure.
• the stent in a collapsed position, may be delivered to the desired location in the body, for example, the heart muscle between the left ventricle and a coronary artery on a catheter.
• the suitably located stents may then be deployed by expanding a balloon placed in the stent such that the diameter of the stent increases from that of the collapsed stent position to the increased diameter of the stent in the expanded position.
• the stent locks in the expanded position, holding the stent against the heart muscle and maintaining the stent in its expanded position with increased diameter.
• the collapsed stent can be placed by suitable minimally invasive techniques such as percutaneous delivery.
• the stent may be constructed of material with memory such that once suitably placed in the body the diameter of the stent expands from a collapsed position to a fully expanded position.
• the stent may adopt a collapsed position at low temperatures, for example temperatures below body temperature, but an expanded position at body temperature.
• valve of the stent is moved to a closed position on increasing the diameter of the stent from a collapsed position to an expanded position when the stent is suitably positioned in the body.
• the valve comprises at least one cantilever member as discussed above. Expansion of diameter of the stent e.g. on deployment of the stent, causes the valve to adopt the closed configuration.
• the cantilever member may be resiliently pivoted at a first end to the stent such that on expansion of the diameter of the stent a second end of the cantilever member pivots to an extended position in which the material forming the valve and defining the aperture of the valve when in the open position is pulled such that the area of the aperture formed by the material is decreased.
• the valve comprises two cantilever members which, on deployment of the stent, cause the diameter of the stent to expand from a collapsed configuration in which the valve portion of the stent is in an open position to an expanded configuration in which the valve is in a closed position.
• the circular cross section increased flow through the stent is enabled and with the > ellipsoidal cross section flow in the second direction is minimised.
• the aperture formed by the resilient material is preferably pulled from a substantially circular cross section to a substantially ellipsoidal cross section, which, in use, restricts the flow of fluid from a second compartment toward a first compartment.
• the diameter and length of the stent depends on its use.
• the stent may be of suitable length to extend between the left ventricle of heart and coronary artery.
• the stent is two to fifteen millimetres in diameter.
• the stent may be constructed such that a number of stents may be positioned "end to end" to increase the effective length of the stent arrangment .
• the stent is resiliently deformable at at least one end to receive and enable connection with a second stent.
• the stent may be shaped at one or both ends to enable connection to a second stent .
• the stent may comprise drug coatings or chemical and / or mechanical coatings such as a TEFLON TM membrane to minimise stenosis.
• stents of the present invention may be used to link or repair two cardiovascular compartments .
• stents of the invention may be used to link a coronary artery to the left ventricle of the heart.
• Stents of the present invention may also be used in non coronary structures e.g. non coronary veins and / or arteries.
• the stents may be used to link a first portion of an ascending venous structure such as the saphenous vein and a second portion of the same ascending venous structure. If the region between the first and second portions of the femoral artery is damaged or occluded, a stent of the invention may be located between the first and second portions to enable the movement of blood from the first portion to the second portion.
• a stent of the present invention may be provided between a first and second portion of a vein e.g. a saphenous vein, to allow blood to flow from the first portion to the second portion, but restrict blood flow from the second portion to the first portion.
• a vein e.g. a saphenous vein
• Such an arrangement could be used to treat varicose veins .
• a method for treating a full or partial occlusion of a blood vessel comprising the step of
• stent means wherein said stent means comprise at least one stent of the first aspect of the invention
• a first end of the lumen of the stent means being in communication with a cardiovascular compartment on one side of the occlusion
• the second end of the lumen of the stent means being in communication with a cardiovascular compartment on the other side of the occlusion allowing blood flow from the first side to the second side of the cardiovascular compartment through the lumen of the stent means .
• the cardiovascular compartments on each side of the occlusion may be in same the blood vessel in which the occlusion is present.
• the cardiovascular compartments may be different compartments, for example the left ventricle of the heart and a coronary artery.
• the stent means may comprise a single stent.
• the stent means may comprise a plurality of stents longitudinally aligned to allow the flow of blood from a stent at a first end of the stent means to a stent at a second end of the stent means.
• the stent means comprise a single stent of the first aspect of the invention.
• the method further comprises the step of positioning the stent means between the compartments, increasing the diameter of the stent means from a reduced diameter in a collapsed position to an increased diameter in an expanded position.
• the method comprises the steps of inserting the stent into position between a first cardiovascular compartment and a second cardiovascular compartment;
• a method for treating varicose veins comprising positioning stent means comprising at least one stent of the first aspect of the invention in a vein or replacing all or part of a vein with stent means comprising at least one stent of the first aspect of the invention.
• stent means may comprise a plurality of stents longitudinally aligned to allow the flow of fluid from a stent at a first end of the stent means to a stent at a second end of the stent means.
• a stent comprising a valve comprising at least one cantilever member.
• the use of such a valve is not limited to uses within the body.
• tube means comprising a valve which comprises at least one cantilever member, having a first end and a second end, said cantilever member being pivoted at said first end to the tube, the cantilever member being resiliently pivotable from a first extended position in which the valve is in a closed position to a second position in which the valve is open.
• Tubes comprising such valves may be used to link a first cardiovascular compartment with a compartment in a cardiovascular device or vice versa .
• tubes comprising such valves may be used to link first and second compartments in a device to transport fluid, for example blood.
• such tubes comprising at least one cantilever member can be used in machines or devices used to move fluid, for example blood, such as dialysis machines.
• a further independent aspect of the present invention is a device for the movement of fluid.
• the fluid is blood.
• Figure 1 is an illustration of an embodiment of a stent of the present invention extending from the left ventricle of the heart into the coronary artery;
• Figure 2 is an enlarged view of an embodiment of a stent of the present invention connecting the left ventricle of the heart to the coronary artery;
• Figure 3 is an illustration of an embodiment of a stent of the present invention wherein a second end of the stent is in a closed position;
• Figure 4 (A) is an illustration of an embodiment of a stent in a collapsed form, (B) is an illustration of an embodiment of a stent of the present invention in an expanded form;
• Figure 5 is an illustration of an embodiment of a stent of the present invention where a second end of a stent is in an open position;
• Figure 6 is an illustration of at least two embodiments of stents of the present invention aligned along their longitudinal axes such that blood can flow from the lumen of a first stent to the lumen of a second adjacent stent;
• Figure 7 is an illustration of stents according to an embodiment of the present invention aligned along their longitudinal length wherein the first stent has a shaped end to receive the second stent and another stent is deformable to receive a stent inside one end.
• the coronary artery 10 is known to branch off the aorta 12 and be positioned along the external surface of the heart wall 14.
• the oxygenated blood flows from the heart 16 into the aorta 12 and onto the rest of the body. Some of the oxygenated blood is circulated along the coronary artery 10 in order to oxygenate the muscles of the heart . In some individuals an occlusion is formed within the coronary artery due to plaque build up. These occlusions can lead to a variety of symptoms and diseases ranging from mild angina to heart attack.
• a stent 18 which extends from the left ventricle 20 of the heart into the coronary artery 10, as shown in figure 2.
• Location of the stent 18 as shown in figure 2 allows blood to flow unobstructed from the left ventricle 20 of the heart to the coronary artery 10.
• Allowing blood flow past or around occlusions of the coronary artery 10 using a stent 18 is preferable to traditional bypass surgery in that the stent 18 may be located and fitted using minimally invasive techniques.
• the stents previously used to connect the left ventricle 20 of the heart to the coronary artery 10 are stents formed by hollow tubes comprising biocompatible material such as titanium alloys, nickel alloys or biocompatible polymers. These tubes may be provided and located between the left ventricle 20 of the heart and the coronary artery 10 in a collapsed position and when suitably located, expanded from a collapsed position to a fully expanded position, using an inflatable balloon catheter or other method.
• a stent of the present invention is provided with a synthetic valve 22, one example of the valve being a portion of flexible resilient material located at the second end 24 of the stent.
• This flexible resilient material is preferably integral with the rest of the stent.
• the valve may be formed during manufacture of the stent, prior to insertion of the stent into the body.
• the valve can be created by the pivotal movement of cantilever members during the movement of the stent from a collapsed position to an expanded position, while the stent is located in the body.
• the resilient material held by two cantilever members 21, forms a substantially cylindrical aperture 28.
• the cantilever members are conjoined to the stent at a first end only and from the rigid biocompatible metal portion 23 of the stent.
• the second ends of the cantilevers move away from each other to an extended position. This movement pulls the resilient material such that its cross sectional shape is changed from substantially circular to substantially ellipsoidal.
• the change in the cross sectional shape restricts the flow of blood in a second direction from the second compartment into the first compartment through the stent. Blood flow through the stent from a first compartment to a second compartment causes the material of the leaflets to be pushed such that the cantilever members resiliently move towards each other and the aperture of the valve becomes substantially circular in cross section.
• the area of the circular cross section is larger that the ellipsoidal cross section and blood can thus easily flow from the first compartment to the second compartment.
• the second ends of the resilient cantilever members can again move away from each other and cause the valve material to form an ellipsoidal cross section.
• the cross sectional shape will not be elliptical, but substantially triangular, rectangular or pentacle shaped.
• Different shaped openings may be used as appropriate to restrict the flow of blood from the second compartment to the first compartment .
• different shaped openings can be chosen to minimise, pressure on the arterial wall caused by the cantilever members.
• a valve formed from resilient material does not require expansion, of the diameter of the stent to cause the resilient material to adopt the closed position.
• cantilever members are not required to pull the material of the valve to a closed position and the valve is manufactured in the closed position. Blood flow in a first direction from the first compartment towards the second compartment causes the resilient material to adopt an open position.
• the blood is pumped by the heart through the stent 18 from the first end 26 located at the left ventricle 20 of the heart towards the second end 24 of the stent located at the coronary artery.
• the blood of the left ventricle of the heart is moved in a first direction through the stent causing the valve to move from an ellipsoidal shape (closed position) to an open (circular cross sectional shape) position.
• the ellipsoidal shape causes the area through which blood can flow from the second compartment to the first compartment to be reduced to 10% the area of the open position of the valve.
• the backflow of blood is thus reduced when blood is not being pumped through the stent from the first compartment to the second compartment.
• reflux of blood through the valve from the second compartment to the first compartment may be 25% that which would be expected if the valve is in the open position.
• the movement of the resilient material in this manner increases the area of the aperture 28 through which the blood can flow from the first compartment (in this case the left ventricle of the heart) into the second compartment (in this case the coronary artery) and allows the unobstructed flow of blood through the valve .
• the resilient material is urged by the material (and in particular embodiments the cantilever members of the rigid portion of the stent) to cause the valve to adopt a resting position, wherein the aperture of the valve into the coronary artery forms an ellipsoidal shape.
• This change in shape of the aperture reduces the area of the aperture located at the second compartment and minimises the blood flow from the coronary artery into the left ventricle of the heart.
• Movement of the stent from a collapsed position to an expanded position causes the stent to be gripped by the heart muscle.
• a flange or other projection may also be provided on the stent to aid location of the stent.
• At least two stents can be aligned along their longitudinal axes such that blood can be communicated from the lumen of a first stent to the lumen of a second adjacent stent.
• blood may be moved from a first proximal position to a second distal position, either between two different cardiovascular compartments such as the left ventricle of the heart and a coronary artery or within the same cardiovascular compartments such as a blood vessel.
• each of the stents comprise a valve
• the stents more closely mimic the situation in actual veins preventing the backflow of blood and allowing blood to be moved upwards.
• An example of when the blood may be required to be moved upwards is in the leg of a patient when said patient is standing.
• each of the stents allow blood to be pushed through the valve on contraction of the heart, but minimise the backward movement of the blood during diastole. This allows blood to be moved up the leg and through the body.
• a first end of a stent may be capable of deformation (as shown in figure 7 (30) ) to allow a second stent to be partially inserted therein.
• the stent may also be widened (figure 7 (32) ) to allow ingress of a second stent as shown in figure 7.
• the valve may be formed from at least two leaflets, which in a resting position are urged towards each other minimising blood flow from the second cardiovascular compartment into the first cardiovascular compartment.
• these leaflets On movement of blood in a first direction through the stent, from the first compartment to the second compartment, these leaflets may be pushed apart from each other, enabling blood flow from the first compartment into the second compartment .
• the two leaflets of the valve will be urged towards each other due to the resilience of the material.
• different methods may be used to align the stents along their longitudinal length such as providing junction means.

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• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Cardiology (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Transplantation (AREA)
• Heart & Thoracic Surgery (AREA)
• Vascular Medicine (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Prostheses (AREA)

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• 2002
  • 2002-09-02 GB GB0220242A patent/GB0220242D0/en not_active Ceased
• 2003
  • 2003-09-02 JP JP2004532348A patent/JP2005537073A/ja active Pending
  • 2003-09-02 AU AU2003267558A patent/AU2003267558A1/en not_active Abandoned
  • 2003-09-02 WO PCT/GB2003/003810 patent/WO2004019814A2/en not_active Application Discontinuation
  • 2003-09-02 EP EP03748250A patent/EP1534172A2/de not_active Withdrawn

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