EP1513404A4 - Intramyocardial injection of autologous bone marrow - Google Patents

Intramyocardial injection of autologous bone marrow

Info

Publication number
EP1513404A4
EP1513404A4 EP03756182A EP03756182A EP1513404A4 EP 1513404 A4 EP1513404 A4 EP 1513404A4 EP 03756182 A EP03756182 A EP 03756182A EP 03756182 A EP03756182 A EP 03756182A EP 1513404 A4 EP1513404 A4 EP 1513404A4
Authority
EP
European Patent Office
Prior art keywords
bone marrow
autologous bone
intramyocardial injection
intramyocardial
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03756182A
Other languages
German (de)
French (fr)
Other versions
EP1513404A1 (en
Inventor
Stephen Epstein
Shmuel Fuchs
Ran Kornowski
Martin B Leon
Kenneth W Carpenter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myocardial Therapeutics Inc
Original Assignee
Myocardial Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myocardial Therapeutics Inc filed Critical Myocardial Therapeutics Inc
Publication of EP1513404A1 publication Critical patent/EP1513404A1/en
Publication of EP1513404A4 publication Critical patent/EP1513404A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
EP03756182A 2002-05-30 2003-05-16 Intramyocardial injection of autologous bone marrow Withdrawn EP1513404A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US160514 1998-09-24
US16051402A 2002-05-30 2002-05-30
PCT/US2003/015529 WO2003101201A1 (en) 2002-05-30 2003-05-16 Intramyocardial injection of autologous bone marrow

Publications (2)

Publication Number Publication Date
EP1513404A1 EP1513404A1 (en) 2005-03-16
EP1513404A4 true EP1513404A4 (en) 2006-01-04

Family

ID=29709714

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03756182A Withdrawn EP1513404A4 (en) 2002-05-30 2003-05-16 Intramyocardial injection of autologous bone marrow

Country Status (5)

Country Link
EP (1) EP1513404A4 (en)
JP (1) JP4111950B2 (en)
AU (1) AU2003232152A1 (en)
CA (1) CA2487410C (en)
WO (1) WO2003101201A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH086437A (en) * 1994-06-17 1996-01-12 Nec Corp Photosensitive drum driving gear of electrophotographic device
CA2554775A1 (en) * 2004-01-30 2005-08-18 Chemgenex Pharmaceuticals, Inc. Naphthalimide dosing by n-acetyl transferase genotyping
US20130078224A1 (en) 2010-03-30 2013-03-28 Life Sciences Research Partners Vzw Induction/monitoring of arteriogenesis using sdf1 and pdgfb or inhibition of phd2
EP3097928A1 (en) * 2015-05-28 2016-11-30 Organes Tissus Régénération Réparation Remplacement Composition for the treatment of brain lesions
EP3097922A1 (en) 2015-05-28 2016-11-30 Denis Barritault Composition for the treatment of tissue lesions
US10881692B2 (en) 2018-04-05 2021-01-05 Medeor Therapeutics, Inc. Compositions for establishing mixed chimerism and methods of manufacture thereof
US10842821B2 (en) 2018-04-05 2020-11-24 Medeor Therapeutics, Inc. Cellular compositions derived from prior organ donors and methods of manufacture and use thereof
US11813376B2 (en) 2018-09-18 2023-11-14 Medeor Therapeutics, Inc. Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013780A (en) * 1996-09-06 2000-01-11 Technion Research & Development Co. Ltd. VEGF145 expression vectors
DK1171165T3 (en) * 1999-03-30 2007-09-03 Ran Kornowski Injection of autologous bone marrow into the myocardium

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ASAHARA T ET AL.: "Gene therapy of endothelial progenitor cell for vascular development in severe ischemic disease", CIRCULATION, vol. 100, 1999, pages I-481, XP009051610 *
ISNER JEFFREY M: "Myocardial gene therapy", NATURE (LONDON), vol. 415, no. 6868, 10 January 2002 (2002-01-10), pages 234 - 239, XP002340057, ISSN: 0028-0836 *
See also references of WO03101201A1 *

Also Published As

Publication number Publication date
JP2005527228A (en) 2005-09-15
EP1513404A1 (en) 2005-03-16
WO2003101201A1 (en) 2003-12-11
AU2003232152A1 (en) 2003-12-19
CA2487410C (en) 2015-03-24
CA2487410A1 (en) 2003-12-11
JP4111950B2 (en) 2008-07-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20041221

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

A4 Supplementary search report drawn up and despatched

Effective date: 20051116

RIN1 Information on inventor provided before grant (corrected)

Inventor name: EPSTEIN, STEPHEN

Inventor name: CARPENTER, KENNETH, W.

Inventor name: LEON, MARTIN B.

Inventor name: KORNOWSKI, RAN

Inventor name: FUCHS, SHMUEL

RIN1 Information on inventor provided before grant (corrected)

Inventor name: FUCHS, SHMUEL

Inventor name: EPSTEIN, STEPHEN

Inventor name: KORNOWSKI, RAN

Inventor name: CARPENTER, KENNETH, W.

Inventor name: LEON, MARTIN B.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20081202