EP1510254A3 - Method and device for detecting an analyte in a fluid - Google Patents

Method and device for detecting an analyte in a fluid Download PDF

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Publication number
EP1510254A3
EP1510254A3 EP20040020359 EP04020359A EP1510254A3 EP 1510254 A3 EP1510254 A3 EP 1510254A3 EP 20040020359 EP20040020359 EP 20040020359 EP 04020359 A EP04020359 A EP 04020359A EP 1510254 A3 EP1510254 A3 EP 1510254A3
Authority
EP
European Patent Office
Prior art keywords
liquid
analyte
substrate
examined
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20040020359
Other languages
German (de)
French (fr)
Other versions
EP1510254A2 (en
Inventor
Hans-Peter Wahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Priority to EP20040020359 priority Critical patent/EP1510254A3/en
Publication of EP1510254A2 publication Critical patent/EP1510254A2/en
Publication of EP1510254A3 publication Critical patent/EP1510254A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Die Anmeldung betrifft ein Verfahren zur Bestimmung eines Analyten in einer Flüssigkeit, wobei das zu untersuchende Flüssigkeitsvolumen (19,20) auf ein Substrat (1) einer Transportebene aufgebracht wird, das zu untersuchende Flüssigkeitsvolumen (19,20) auf diesem Substrat (1) an den Ort der Untersuchung bewegt wird, wobei die Flüssigkeit ausschließlich mit dem Substrat der Transportebene in Kontakt ist, die zu untersuchende Flüssigkeit am Ort der Untersuchung zusätzlich mit einem sensorischen Element (21) in Kontakt gebracht wird, welches sich in einer dem Substrat gegenüberliegenden Nachweisebene befindet, und der Analyt im zu untersuchenden Flüssigkeitsvolumen direkt oder indirekt durch das sensorische Element bestimmt wird. Die Anmeldung betrifft weiterhin eine Vorrichtung zur Bestimmung eines Analyten in einer Flüssigkeit entsprechend den erfindungsgemäßen Verfahren.

Figure 00000001
The application relates to a method for determining an analyte in a liquid, wherein the liquid volume (19, 20) to be examined is applied to a substrate (1) of a transport plane, the liquid volume (19, 20) to be examined on this substrate (1) the location of the examination is moved, wherein the liquid is in contact exclusively with the substrate of the transport plane, the liquid to be examined is additionally brought into contact with a sensory element (21) which is located in a detection plane opposite to the substrate and the analyte in the volume of fluid to be tested is determined directly or indirectly by the sensory element. The application further relates to a device for determining an analyte in a liquid according to the methods of the invention.
Figure 00000001
EP20040020359 2003-08-30 2004-08-27 Method and device for detecting an analyte in a fluid Withdrawn EP1510254A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20040020359 EP1510254A3 (en) 2003-08-30 2004-08-27 Method and device for detecting an analyte in a fluid

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03019811 2003-08-30
EP03019811 2003-08-30
EP20040020359 EP1510254A3 (en) 2003-08-30 2004-08-27 Method and device for detecting an analyte in a fluid

Publications (2)

Publication Number Publication Date
EP1510254A2 EP1510254A2 (en) 2005-03-02
EP1510254A3 true EP1510254A3 (en) 2005-09-28

Family

ID=34105742

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20040020359 Withdrawn EP1510254A3 (en) 2003-08-30 2004-08-27 Method and device for detecting an analyte in a fluid

Country Status (1)

Country Link
EP (1) EP1510254A3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1885885A4 (en) * 2005-05-11 2008-08-27 Nanolytics Inc Method and device for conducting biochemical or chemical reactions at multiple temperatures
JP4835311B2 (en) * 2006-08-03 2011-12-14 横河電機株式会社 Cartridge inspection device
DE102008028404B4 (en) * 2008-06-17 2013-07-18 Saw Instruments Gmbh Cartridge with integrated SAW sensor
WO2013009927A2 (en) 2011-07-11 2013-01-17 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based assays

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517160A (en) * 1979-04-14 1985-05-14 Olympus Optical Company Limited Automatic analyzing apparatus
WO2000051720A2 (en) * 1999-03-03 2000-09-08 Symyx Technologies, Inc. Chemical processing microsystems and methods for preparing and using same
WO2002018785A1 (en) * 2000-08-31 2002-03-07 Advanced Sensor Technologies Micro-fluidic system
US20020187564A1 (en) * 2001-06-08 2002-12-12 Caliper Technologies Corp. Microfluidic library analysis
WO2004101152A1 (en) * 2003-05-09 2004-11-25 Caliper Life Sciences, Inc. Automated sample analysis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517160A (en) * 1979-04-14 1985-05-14 Olympus Optical Company Limited Automatic analyzing apparatus
WO2000051720A2 (en) * 1999-03-03 2000-09-08 Symyx Technologies, Inc. Chemical processing microsystems and methods for preparing and using same
WO2002018785A1 (en) * 2000-08-31 2002-03-07 Advanced Sensor Technologies Micro-fluidic system
US20020187564A1 (en) * 2001-06-08 2002-12-12 Caliper Technologies Corp. Microfluidic library analysis
WO2004101152A1 (en) * 2003-05-09 2004-11-25 Caliper Life Sciences, Inc. Automated sample analysis

Also Published As

Publication number Publication date
EP1510254A2 (en) 2005-03-02

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