EP1501869A4 - Phosphorylated histone h2b as an apoptosis marker - Google Patents

Phosphorylated histone h2b as an apoptosis marker

Info

Publication number
EP1501869A4
EP1501869A4 EP02756877A EP02756877A EP1501869A4 EP 1501869 A4 EP1501869 A4 EP 1501869A4 EP 02756877 A EP02756877 A EP 02756877A EP 02756877 A EP02756877 A EP 02756877A EP 1501869 A4 EP1501869 A4 EP 1501869A4
Authority
EP
European Patent Office
Prior art keywords
apoptosis marker
phosphorylated histone
histone
phosphorylated
apoptosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02756877A
Other languages
German (de)
French (fr)
Other versions
EP1501869A2 (en
Inventor
C David Allis
Wang L Cheung
Kozo Ajiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Virginia UVA
University of Virginia Patent Foundation
Original Assignee
University of Virginia UVA
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Virginia UVA, University of Virginia Patent Foundation filed Critical University of Virginia UVA
Priority claimed from PCT/US2002/024405 external-priority patent/WO2003014142A2/en
Publication of EP1501869A2 publication Critical patent/EP1501869A2/en
Publication of EP1501869A4 publication Critical patent/EP1501869A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
EP02756877A 2001-08-03 2002-08-01 Phosphorylated histone h2b as an apoptosis marker Withdrawn EP1501869A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31001501P 2001-08-03 2001-08-03
US310015P 2001-08-03
US36438602P 2002-03-14 2002-03-14
US364386P 2002-03-14
US37589202P 2002-04-26 2002-04-26
US375892P 2002-04-26
PCT/US2002/024405 WO2003014142A2 (en) 2001-08-03 2002-08-01 Phosphorylated histone h2b as an apoptosis marker

Publications (2)

Publication Number Publication Date
EP1501869A2 EP1501869A2 (en) 2005-02-02
EP1501869A4 true EP1501869A4 (en) 2006-01-11

Family

ID=33545224

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02756877A Withdrawn EP1501869A4 (en) 2001-08-03 2002-08-01 Phosphorylated histone h2b as an apoptosis marker

Country Status (1)

Country Link
EP (1) EP1501869A4 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241782A (en) * 1990-03-08 1991-09-11 Morinaga & Co Serodiagnosis method and the kit used therefor
WO1992011029A1 (en) * 1990-12-17 1992-07-09 The Johns Hopkins University Suppression of immune responses with oligomeric forms of antigen of controlled chemistry
US5637465A (en) * 1993-06-03 1997-06-10 Boehringer Mannheim Gmbh Method for the detection of a programmed or induced cell death of eukaryotic cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241782A (en) * 1990-03-08 1991-09-11 Morinaga & Co Serodiagnosis method and the kit used therefor
WO1992011029A1 (en) * 1990-12-17 1992-07-09 The Johns Hopkins University Suppression of immune responses with oligomeric forms of antigen of controlled chemistry
US5637465A (en) * 1993-06-03 1997-06-10 Boehringer Mannheim Gmbh Method for the detection of a programmed or induced cell death of eukaryotic cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AJIRO KOZO: "Histone H2B phosphorylation in mammalian apoptotic cells: An association with DNA fragmentation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 1, 7 January 2000 (2000-01-07), pages 439 - 443, XP002353258, ISSN: 0021-9258 *
CHEUNG P; ALLIS C D; SASSONE-CORSI P: "Signaling to chromatin through histone modifications.", CELL, vol. 103, no. 2, 13 October 2000 (2000-10-13), US, pages 263 - 271 *
CHEUNG WANG L ET AL: "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.", CELL, vol. 113, no. 4, 16 May 2003 (2003-05-16), pages 507 - 517, XP002353259, ISSN: 0092-8674 *
GRAVES J D ET AL: "Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 4 MAY 2001, vol. 276, no. 18, 4 May 2001 (2001-05-04), pages 14909 - 14915, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP1501869A2 (en) 2005-02-02

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Legal Events

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