EP1501869A4 - PHOSPHORYLATED HISTON H2B AS APOPTOSEMARKER - Google Patents

PHOSPHORYLATED HISTON H2B AS APOPTOSEMARKER

Info

Publication number
EP1501869A4
EP1501869A4 EP02756877A EP02756877A EP1501869A4 EP 1501869 A4 EP1501869 A4 EP 1501869A4 EP 02756877 A EP02756877 A EP 02756877A EP 02756877 A EP02756877 A EP 02756877A EP 1501869 A4 EP1501869 A4 EP 1501869A4
Authority
EP
European Patent Office
Prior art keywords
apoptosemarker
histon
phosphorylated
phosphorylated histon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02756877A
Other languages
German (de)
French (fr)
Other versions
EP1501869A2 (en
Inventor
C David Allis
Wang L Cheung
Kozo Ajiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UVA Licensing and Ventures Group
University of Virginia UVA
Original Assignee
University of Virginia UVA
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Virginia UVA, University of Virginia Patent Foundation filed Critical University of Virginia UVA
Priority claimed from PCT/US2002/024405 external-priority patent/WO2003014142A2/en
Publication of EP1501869A2 publication Critical patent/EP1501869A2/en
Publication of EP1501869A4 publication Critical patent/EP1501869A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
EP02756877A 2001-08-03 2002-08-01 PHOSPHORYLATED HISTON H2B AS APOPTOSEMARKER Withdrawn EP1501869A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31001501P 2001-08-03 2001-08-03
US310015P 2001-08-03
US36438602P 2002-03-14 2002-03-14
US364386P 2002-03-14
US37589202P 2002-04-26 2002-04-26
US375892P 2002-04-26
PCT/US2002/024405 WO2003014142A2 (en) 2001-08-03 2002-08-01 Phosphorylated histone h2b as an apoptosis marker

Publications (2)

Publication Number Publication Date
EP1501869A2 EP1501869A2 (en) 2005-02-02
EP1501869A4 true EP1501869A4 (en) 2006-01-11

Family

ID=33545224

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02756877A Withdrawn EP1501869A4 (en) 2001-08-03 2002-08-01 PHOSPHORYLATED HISTON H2B AS APOPTOSEMARKER

Country Status (1)

Country Link
EP (1) EP1501869A4 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241782A (en) * 1990-03-08 1991-09-11 Morinaga & Co Serodiagnosis method and the kit used therefor
WO1992011029A1 (en) * 1990-12-17 1992-07-09 The Johns Hopkins University Suppression of immune responses with oligomeric forms of antigen of controlled chemistry
US5637465A (en) * 1993-06-03 1997-06-10 Boehringer Mannheim Gmbh Method for the detection of a programmed or induced cell death of eukaryotic cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241782A (en) * 1990-03-08 1991-09-11 Morinaga & Co Serodiagnosis method and the kit used therefor
WO1992011029A1 (en) * 1990-12-17 1992-07-09 The Johns Hopkins University Suppression of immune responses with oligomeric forms of antigen of controlled chemistry
US5637465A (en) * 1993-06-03 1997-06-10 Boehringer Mannheim Gmbh Method for the detection of a programmed or induced cell death of eukaryotic cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AJIRO KOZO: "Histone H2B phosphorylation in mammalian apoptotic cells: An association with DNA fragmentation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 1, 7 January 2000 (2000-01-07), pages 439 - 443, XP002353258, ISSN: 0021-9258 *
CHEUNG P; ALLIS C D; SASSONE-CORSI P: "Signaling to chromatin through histone modifications.", CELL, vol. 103, no. 2, 13 October 2000 (2000-10-13), US, pages 263 - 271 *
CHEUNG WANG L ET AL: "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.", CELL, vol. 113, no. 4, 16 May 2003 (2003-05-16), pages 507 - 517, XP002353259, ISSN: 0092-8674 *
GRAVES J D ET AL: "Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 4 MAY 2001, vol. 276, no. 18, 4 May 2001 (2001-05-04), pages 14909 - 14915, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP1501869A2 (en) 2005-02-02

Similar Documents

Publication Publication Date Title
NL301200I2 (en) Voclosporin
NO20040084L (en) Peptide-based compounds
DE60235192D1 (en) COVER
DE60227853D1 (en) Substituted pyridinylamines
IS6915A (en) composition
BR0210619A (en) composition
DE50206892D1 (en) SUBSTITUTED IMIDAZOTRIAZINONE
IS7081A (en) composition
NO20034452L (en) Disease-associated protein
DK1373228T3 (en) Substituted fluoroalkoxyphenylsulfonylureas
DE50213651D1 (en) SUBSTITUTED 4-AMINOCYCLOHEXANOLE
DE60211116D1 (en) COMPENSATION MECHANISM
EP1359932A4 (en) TIP39 POLYPEPTIDE
DE50309081D1 (en) NEW DIKETOPYRROLOPYROLPIGMENTS
ITTO20020747A0 (en) COMPOSITION
DE50209213D1 (en) GMR module
EP1501869A4 (en) PHOSPHORYLATED HISTON H2B AS APOPTOSEMARKER
ITTO20020745A0 (en) COMPOSITION
NO20014954D0 (en) Peptide-based compounds
SE0102618D0 (en) Novel compounds
SE0102403D0 (en) Novel compounds
SE0103271D0 (en) Novel compounds
SE0102053D0 (en) Novel compounds
SE0101617D0 (en) Novel compounds
SE0104473D0 (en) Novel Compounds

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040301

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/53 19850101ALI20051115BHEP

Ipc: C07K 14/00 19950101ALI20051115BHEP

Ipc: C07K 16/18 19950101ALI20051115BHEP

Ipc: C07K 16/00 19950101AFI20041215BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20051128

17Q First examination report despatched

Effective date: 20070215

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20081209