EP1490089A4 - Peptides selectively lethal to malignant and transformed mammalian cells - Google Patents
Peptides selectively lethal to malignant and transformed mammalian cellsInfo
- Publication number
- EP1490089A4 EP1490089A4 EP03760194A EP03760194A EP1490089A4 EP 1490089 A4 EP1490089 A4 EP 1490089A4 EP 03760194 A EP03760194 A EP 03760194A EP 03760194 A EP03760194 A EP 03760194A EP 1490089 A4 EP1490089 A4 EP 1490089A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- malignant
- mammalian cells
- transformed mammalian
- peptides selectively
- selectively lethal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36378502P | 2002-03-12 | 2002-03-12 | |
US363785P | 2002-03-12 | ||
PCT/US2003/007687 WO2003105880A1 (en) | 2002-03-12 | 2003-03-12 | Peptides selectively lethal to malignant and transformed mammalian cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1490089A1 EP1490089A1 (en) | 2004-12-29 |
EP1490089A4 true EP1490089A4 (en) | 2006-08-30 |
Family
ID=29736031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03760194A Withdrawn EP1490089A4 (en) | 2002-03-12 | 2003-03-12 | Peptides selectively lethal to malignant and transformed mammalian cells |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1490089A4 (en) |
JP (1) | JP2005520866A (en) |
AU (1) | AU2003277292A1 (en) |
CA (1) | CA2477878C (en) |
WO (1) | WO2003105880A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040038902A1 (en) * | 2000-04-05 | 2004-02-26 | Pincus Matthew R. | Peptides selectively lethal to malignant and transformed mammalian cells |
JP2008505846A (en) * | 2004-01-13 | 2008-02-28 | ザ リサーチ ファンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | Peptides that are selectively lethal to malignant and transformed mammalian cells |
WO2005074521A2 (en) * | 2004-01-30 | 2005-08-18 | The Trustees Of Columbia University In The City Of New York | C-TERMINAL p53 PALINDROMIC PEPTIDE THAT INDUCES APOPTOSIS OF CELLS WITH ABERRANT p53 AND USES THEREOF |
WO2008081812A1 (en) * | 2006-12-28 | 2008-07-10 | Toagosei Co., Ltd. | Anti-tumor peptide and use thereof |
US9539327B2 (en) | 2007-11-26 | 2017-01-10 | The Research Foundation For The State University Of New York | Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells |
WO2010040051A2 (en) * | 2008-10-03 | 2010-04-08 | The Research Foundation Of State University Of New York | Membrane resident peptide in anti-cancer peptides causes tumor cell necrosis rather than apoptosis of cancer cells |
WO2011005219A1 (en) * | 2009-07-07 | 2011-01-13 | Agency For Science, Technology And Research | Novel mdm2 binding peptides and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996002642A1 (en) * | 1994-07-20 | 1996-02-01 | University Of Dundee | INTERRUPTION OF BINDING OF MDM2 AND p53 PROTEIN AND THERAPEUTIC APPLICATION THEREOF |
WO2004081030A2 (en) * | 2003-03-12 | 2004-09-23 | The Research Foundation Of The State University Of New York | Peptides selectively lethal to malignant and transformed mammalian cells |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4215102A (en) * | 1979-01-05 | 1980-07-29 | Lee Sin H | Cytochemical agents and methods for the detection of steroid hormone receptors in human tissues |
US5369012A (en) * | 1992-03-26 | 1994-11-29 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method of making a membrane having hydrophilic and hydrophobic surfaces for adhering cells or antibodies by using atomic oxygen or hydroxyl radicals |
-
2003
- 2003-03-12 CA CA2477878A patent/CA2477878C/en not_active Expired - Lifetime
- 2003-03-12 AU AU2003277292A patent/AU2003277292A1/en not_active Abandoned
- 2003-03-12 EP EP03760194A patent/EP1490089A4/en not_active Withdrawn
- 2003-03-12 JP JP2004512781A patent/JP2005520866A/en active Pending
- 2003-03-12 WO PCT/US2003/007687 patent/WO2003105880A1/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996002642A1 (en) * | 1994-07-20 | 1996-02-01 | University Of Dundee | INTERRUPTION OF BINDING OF MDM2 AND p53 PROTEIN AND THERAPEUTIC APPLICATION THEREOF |
WO2004081030A2 (en) * | 2003-03-12 | 2004-09-23 | The Research Foundation Of The State University Of New York | Peptides selectively lethal to malignant and transformed mammalian cells |
Non-Patent Citations (2)
Title |
---|
KANOVSKY MECHEAL ET AL: "Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 22, 23 October 2001 (2001-10-23), pages 12438 - 12443, XP002391084, ISSN: 0027-8424 * |
See also references of WO03105880A1 * |
Also Published As
Publication number | Publication date |
---|---|
CA2477878A1 (en) | 2003-12-24 |
JP2005520866A (en) | 2005-07-14 |
CA2477878C (en) | 2013-05-14 |
AU2003277292A1 (en) | 2003-12-31 |
WO2003105880A1 (en) | 2003-12-24 |
EP1490089A1 (en) | 2004-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20041004 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060801 |
|
17Q | First examination report despatched |
Effective date: 20061005 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20070417 |