EP1485938B1

EP1485938B1 - Self-aligned ion guide construction

Info

Publication number: EP1485938B1
Application number: EP02778308A
Authority: EP
Inventors: Roger C. Tong
Original assignee: Varian Inc
Current assignee: Varian Inc
Priority date: 2002-03-12
Filing date: 2002-09-24
Publication date: 2010-06-02
Anticipated expiration: 2022-09-24
Also published as: EP1485938A1; DE60236626D1; WO2003079398A1; JP3927178B2; JP2005520301A

Description

FIELD OF THE INVENTION

The invention relates in general to an assemblage of rods for generation of multipole fields to be employed for ion guide and mass analysis purposes, and more particularly to economical and precise construction arrangements thereof.

BACKGROUND OF THE INVENTION

The transport of ions over some spatial interval is a functional description of an ion guide. Such an ion guide is an electro-optical device for confining the ion trajectories to a generally axial locus and that confinement is achieved through the influence of an appropriate electric multipole field distribution that returns a non-axially directed ion trajectory back toward the axis. The most common structural form for such a guide consists of a number, 2N, of metal rods arranged equidistant from a central axis. Opposite and/or 180° phase shifted AC potentials are applied in common to alternate rods. The efficacy of the ion guide depends upon precise geometry of the rod assembly as well as the congruence of virtual source and exit apertures of the guide with the real apertures of devices between which the ion guide operates. In one system (a mass spectrometer), an ion source is disposed spaced apart from a mass analyzer with the ion guide therebetween. Separation of the ionization and mass analysis procedures and devices permits optimization of these procedures and hardware subject to the efficiency of the ion guide.
The prior art has approached ion guide construction through support of the array of rods with at least a pair of axially spaced support assemblies having holes for retaining the relative positions of the rods and also for providing the desired common electrical contact of alternate rods. These prior art support assemblies typically include a ceramic insulating ring having holes through which the rods pass, to define the relative disposition of the rods. Metal rings are secured to the opposite faces of the ceramic insulator and each metal ring forms a common electrical contact with one corresponding sub-set of alternate rods while maintaining electrical isolation from the other sub-set of rods. Such arrangements are described in US 6,329,654 B1 and in 5,852,294 .
The above mentioned US 6,329,654 B 1 further discloses a multipole rod assembly for ion guides in which the rods are equidistantly spaced from the central ion guiding axis. The rods are supported by ceramic discs. Gold coated metal discs are arranged on both sides of the ceramic discs rotationally offset by 60° and are electrically isolated from each other. Each of the metal discs electrically connects to every second to the six rods by solder connections and is electrically insulated from the other 3 rods. Thus the potential between the rods is supplied via the interdigital metal discs. The metal discs are screwed to the ceramic discs.

SUMMARY OF THE INVENTION

It is desired to achieve a precise geometry for an ion guide with a simplified assembly.
The invention is defined in claims 1, 5, 6 and 10 respectively.
Particular embodiments are set out in the dependent claims. This is obtained with a support collar construction employing an insulating ring having axial extent sufficient to accommodate two axially spaced peripheral grooves on the outer azimuthal surface. An inner azimuthal surface has rod conformal arcuate surface portions formed therein to locate each rod. Each groove is characterized by a set of radially directed holes azimuthally spaced 2π/N radians for an assembly of 2N rods. The angular positions for the hole set for one groove is staggered π/N with respect to the other groove. Common electrical contact for one sub-set of N rods is realized by a conductor disposed within the groove, which contacts a rod through the respective radially directed hole.
The arcuate surface receives and constrains the outward radial locus of a rod. Electrical contact is established with a strong conducting wire captured in the groove and stressed such that when bonded through the holes to respective rods, there is an outward force on the rods balancing the inward constraining force of the arcuate surface portion against the rod, e.g., preloading the rod against the collar. As a result the ion guide assembly is a robust self aligned structure and is characterized by an aperture limited only by the rods themselves.

BRIEF DESCRIPTION OF THE FIGURES

Figure 1 shows one context for the invention.
Figure 2a is a perspective view of an ion guide assembly according to the invention.
Figure 2b is an elevation of the ion guide of figure 2a.
Figure 2c is a section through one support collar of the invention.
Figure 3 shows a detail of a support collar of the invention.
Figure 4 is a perspective representation of an alternative form of constructing an ion guide similar to figure 2a.

DETAILED DESCRIPTION OF THE INVENTION

The context of the invention is schematically shown in figure 1 for one representative example. For this example, an ionization chamber 12 operates on a sample to produce an ionized portion of the sample that is extracted from the ionization chamber 12 for transport through ion guide 16 to analyzer 14. Schematically shown herein is an ion trap mass analyzer comprising the ion trap 18, detector/display, recorder 20 and trap support electronics 22. The separation of the ionization process from the analysis is often advantageous for a variety of reasons outside the scope of this work.
The ion guide 16 shown in figures 2a and 2b incorporates features of the present invention, as specialized for the example, a hexapole ion guide. An assembly 30 of 6 cylindrical rods 32 are disposed axially equidistant on a circular locus orthogonal to the rod axes. The assembly 30 further includes one or more (preferably, two) insulating collars 34 and 36 of generally cylindrical geometry Figure 3 is a detailed illustration of the salient features of one such collar. Two grooves, 38 and 39, are inscribed on the outer azimuthal periphery of collars 34 and 36 and mutually axially displaced. The inner azimuthal periphery is characterized by rod-conformal arcuate (scalloped) surface portions 40 disposed at equal angular increments (here 60°). Each scalloped portion 40 defines the radial location of the rod in contact therewith and determines the axis of that individual rod, which is most usually parallel to the axes the other rods. Each groove 38 and 39 has radially directed holes formed to coincide with alternate scalloped portions 40. Conductors, preferably wires 42 and 44, are disposed within respective grooves 38 and 39 and are suitably bonded through the radially directed holes to the corresponding rods to form electrical contact as well as a durable mechanical bond therewith. As an example, figure 3 shows a wire 44 bonded by spot weld 48 through hole 45 to one underlying rod 32. The wires 42 and 44 are captured in the grooves 38 and 39 under sufficient stress that, when bonded through corresponding holes to respective rods, such rods are preloaded in respect to the collars at the scalloped portions.
Assembly of the ion guide 16 is practiced by arranging the rods about a mandrel centrally disposed within the set of rods to urge the rods outwardly against the scalloped surface portions 40. A wire 42, for example, is inwardly urged against the bottom of the groove and through each radially directed hole and preferably spot welded to the respective rod 32. The mandrel is then withdrawn. For a hexapole ion guide 16 comprising 6 rods (denominated A, B, C, D, E and F) each urged against scalloped portions A', B', C', D', E' and F', respectively, a wire in groove 38 for example, communicates with rods A, C and E while a wire in groove 39 would contact rods B, D and F through the corresponding radially directed holes. Electrical contact from each sub-set of rods may be effected from the wire or by a radially outward directed lead from a selected rod of each subset of rods.
In one ion guide assembly of this invention, the insulating collars are formed from a plastic such as poly-ether-ether-ketone (PEEK) to produce a robust but flexible structure. Another choice is polyphnylene sulfide (PPS), preferably glass filled for temperature stability. Ceramic, or other brittle insulator would also suffice for this purpose. Rods may be constructed of any suitable conductor, although it is generally desired that these be relatively chemically inert to an ion flux of varying character. Stainless steel wire has been used for the wire conductor 42 and spot welding to rods 32 has proved a simple and effective bond. The inventive arrangement is inherently self-aligning and easily assembled. The resulting ion guide exhibits no limiting inner diameter due to the support collars as would be the case where rods are led through holes in such supporting member. It is useful for one collar to further include a radial extension forming a flange 46 to mate with a terminal device as represented by ionization chamber 12 or analyzer 18.
A hexapole ion guide in accord with the above description has been constructed having gross dimensions of 6 cm. in length with outer collar diameter (excluding flange) of 1.27 cm (0.50 inch). The rods were 2.4 mm. stainless steel disposed at equal 60° increments on a circle of 0.737 cm (0.290 inch) diameter. The connecting wires 42 were 0.051 cm (0.020 in) stainless steel. The construction as described herein has been used in a mass spectrometer system as indicated in figure 1 and is particularly robust and tolerant of disassembly and re-assembly for cleaning, maintenance and the like.
In another embodiment illustrated in figure 4, the ion guide structure described above is constructed through a casting process by placing the rods 32 in a fixture 52 that establishes the desired spatial relationship of such rods. Conductor wires 42 are then bonded to the appropriate rods as described, via solder or tack welding. A mold 50 forms a slip fit about the assembly of the fixture 52 and rods 32 sufficient to contain a (temporary) fluid phase insulating medium, such as an epoxy. Any of a wide choice of epoxy materials may be found to be useful and a particular choice will depend upon electric field strength to be applied, outgassing characteristics, possible contaminating effects (upon the analysis instrument) realized from low energy ion induced erosion, mechanical and thermal properties and the like. These aspects are outside the scope of this work. By way of example, a commercially available epoxy, Epoxi-patch (1C-white), available from Dexter Corporation, Seabrook, NH, has been employed with satisfactory results. Molds 50 and fixture 52 were constructed of tetrafluoroethylene (Teflon) which will easily slide off the resulting casting.
It will be clear to one skilled in the art that the above embodiments may be altered in many ways without departing from the scope of the invention. Suitable applications of the conveyer may include applications other than mass spectroscopy applications. The ion guide need not be straight, but can take on a desired non-linear trajectory. Lengthy guides may be achieved with more collars spaced appropriately. Accordingly, the scope of the invention should be determined by the following claims.

Claims

An ion guide assembly (30) comprising:
2N rods (32) equidistantly spaced from a central axis, and

at least one support collar (34, 36) having rod conformal arcuate surface portions (40) on its inner surface, wherein each surface portion (40) receiver and defines the radial location of are of said rods (32) and for electrically connecting N alternate said rods (32), whereby adjacent rods (32) are electrically unconnected,

characterized in that

said collar (34, 36) comprises an insulating ring having first and second axially displaced grooves (38, 39) formed on the outer azimuthal periphery thereof, each said groove (38, 39) intercepting N radially directed holes (45) therethrough, said radially directed holes (45) each aligned with one of said rods conformal arcuate surface portions (40) on the inner azimuthal periphery for locating corresponding said alternate rods, whereby said N holes (45) of said first groove (38) are azimuthally shifted by π/N with respect to the N holes (45) of said second groove (39), and

an electrical conductor (42, 44) is disposed in each said groove (38, 39) to contact and bond with a corresponding said rod (32) through a respective said radially directed hole (45).
The ion guide assembly of claim 1, wherein said conductor (42, 44) comprises a wire and said wire is spotwelded to said corresponding rod (32).
The ion guide assembly of claim 1, wherein N = 3 and said ion guide supports a 2-dimensional hexapolar field.
The ion guide assembly of claim 1, wherein said axis comprises a straight line.
A system for ion analysis comprising an ion source (12) and an analysis device (14, 16) spaced apart from said ion source, and therebetween an ion guide assembly (30) according to any of the previous claims 1 to 4.
A method of stably supporting 2N rods (32) in an ion guide assembly (30) to produce a 2-dimensional electric multipole field distribution comprising:
(a) forming 2N rod conformal arcuate surface portions (40) equally spaced azimuthally on the inner surface of an insulating ring (34, 36),

(b) producing first and second grooves (38, 39) on the outer peripheral surface of said ring (34, 36),

(c) drilling N radially directed holes (45) in each said groove (38, 39) in alignment with alternating corresponding said rod conformal surfaces,

(d) bringing each said 2N rods (32) into intimate contact with said rod conformal surfaces,

(e) separately disposing within each said first and second grooves (38, 39) respective first and second electrical conductors (42, 44) and contacting and bonding each said rod (32) through a corresponding radially directed hole (45) with one said conductor.
The method of claim 6, further comprising energizing said rod assembly (30) by contacting said first conductor (42) with a first electrical potential and contacting the second conductor (44) with an opposite polarity potential.
The method of claim 7, wherein said opposite polarity potentials comprise a DC voltage drop.
The method of claim 7, wherein said opposite polarity potentials comprise AC voltages having a substantial phase shift therebetween.
A method of stably supporting 2N rods (32) in an ion guide assembly (30) to produce a 2 dimensional electric multipole field distribution comprising:
(a) capturing 2N rod conformal arcuate surface portions (40) equally spaced azimuthally on the outer surface of a fixture (52),

(b) bonding a first wire (42) to alternate said rods (32) for electrical contact therewith while establishing an electrically isolate relation to rods (32) disposed between said alternate said rods, and bonding a second wire (44) to each said rods (32) disposed between said alternate said rods while establishing an electrically isolate relation to said alternate said rods, whereby electrical conducting bonds are established between said first wire (42) and a first group of N rods (32) and electrical conducting bonds are established between said second wire (44) and a second group of N rods (32),

(c) placing a mold (50) surrounding said rods (32) in the regions proximate said bonds,

(d) introducing a castable electrically insulating medium in a temporary fluid phase into said mold (50) and allowing said medium to transform into a solid phase, and

(e) removing said mold (50) and said fixture (52) from the resulting assembly (30) of said rods (32).
The method of claim 10, further comprising providing a first electrical lead to said first group of rods (32) and a second electrical lead to said second group of rods (32).