EP1455881A1 - Guide wire with adjustable flexibility - Google Patents

Guide wire with adjustable flexibility

Info

Publication number
EP1455881A1
EP1455881A1 EP02776024A EP02776024A EP1455881A1 EP 1455881 A1 EP1455881 A1 EP 1455881A1 EP 02776024 A EP02776024 A EP 02776024A EP 02776024 A EP02776024 A EP 02776024A EP 1455881 A1 EP1455881 A1 EP 1455881A1
Authority
EP
European Patent Office
Prior art keywords
guide wire
variable stiffness
flexibility
polymeric member
heat source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02776024A
Other languages
German (de)
French (fr)
Other versions
EP1455881B1 (en
Inventor
Stephen Griffin
Gregory E. Mirigian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Publication of EP1455881A1 publication Critical patent/EP1455881A1/en
Application granted granted Critical
Publication of EP1455881B1 publication Critical patent/EP1455881B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/0915—Guide wires having features for changing the stiffness
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09175—Guide wires having specific characteristics at the distal tip

Definitions

  • the present invention generally relates to intravascular guide wires.
  • the present invention relates to intravascular guide wires having adjustable flexibility.
  • Intravascular guide wires are often used to facilitate the delivery of therapeutic and diagnostic devices to remote vascular sites in the human body.
  • intravascular guide wires are used to navigate through a patient's vasculature from a convenient location outside the patient's body, to a target site inside the patient's body requiring diagnosis and/or therapy. Once access to the target site has been provided by the guide wire, a therapeutic or diagnostic device (e.g., catheter) may then be advanced over the guide wire to the target site, and the desired therapeutic or diagnostic steps may be performed.
  • a therapeutic or diagnostic device e.g., catheter
  • the guide wire To facilitate navigation in tortuous vasculature, it is desirable that the guide wire have a relatively flexible distal end. To provide good support for devices advanced over the guide wire, it is desirable that the guide wire have a relatively stiff distal end. Conventional guide wires typically address these competing needs by establishing a compromise in flexibility and stiffness. However, it would be desirable to have a guide wire that does not compromise these competing needs.
  • the present invention provides, in one exemplary embodiment, a guide wire that has a distal portion with adjustable flexibility.
  • the guide wire includes a distal polymeric member and a heat source.
  • the heat source may be activated by a power supply, which causes the polymeric member to increase in temperature, to thereby increase the flexibility of the distal portion of the guide wire.
  • the polymeric member may comprise a shape memory polymer having a glass transition temperature, wherein the increase in temperature is across the glass transition temperature.
  • the increase in flexibility of the distal portion of the guide wire enhances the ability of the guide wire to navigate vasculature of varying degrees of tortuosity.
  • the heat source may be deactivated, which causes the polymeric member to decrease in temperature, to thereby increase the stiffness of the distal portion of the guide wire and provide enhanced support for devices advanced thereon.
  • Figure 1 is a plan view of a guide wire system, including a guide wire, a controller/power source and a coupling/lead therebetween, in accordance with an exemplary embodiment of the present invention
  • Figure 2 is a longitudinal cross-sectional view taken along line 2 - 2 in Figure
  • the guide wire system includes a guide wire 10 connected to a controller and power source 50 by a coupling 40 and lead 60.
  • Guide wire 10 includes an elongate shaft 12 having a proximal portion 14 and a distal portion 16.
  • Distal portion 16 includes a soft atraumatic tip 18.
  • the proximal portion 14 of the shaft 12 is relatively stiff to provide pushability and torquability, and the distal portion 16 has adjustable flexibility to provide trackability in navigating tortuous vasculature and support for devices advanced thereover.
  • the guide wire 10 may have conventional dimensions and may be formed of conventional materials using conventional techniques known for intravascular guide wires used to navigate the human vasculature to remote locations including, but not limited to, the neurovasculature, the coronary vasculature, and the peripheral vasculature.
  • the distal portion 16 of the guide wire 10 includes a heat source that is thermally connected to a polymeric member that increases in flexibility when heated, and increases in stiffness (e.g., returns to its nominal flexibility or stiffness at body temperature) when cooled.
  • a heat source that is thermally connected to a polymeric member that increases in flexibility when heated, and increases in stiffness (e.g., returns to its nominal flexibility or stiffness at body temperature) when cooled.
  • the flexibility of the polymeric member, and thus the flexibility of the distal portion 16 may be adjusted.
  • the flexibility of the distal portion 16 may be increased by activating the heat source, which enhances the ability of the guide wire 10 to navigate tortuous vasculature to a target site.
  • the heat source may be deactivated to cause the distal portion 16 to increase in stiffness, which enhances guide wire 10 support provided for devices (e.g., catheters) advanced thereon.
  • a controller/power supply 50 is connected by lead 60 to a coupling 40 which is releasably and rotatably connected to the proximal portion 14 of the guide wire shaft 12.
  • Controller/power supply 50 may comprise a conventional power supply with conventional control circuitry to provide a constant or modulated AC or DC signal.
  • the signal is transmitted by lead 60, which may comprise two (or more) conductors.
  • the conductors in the lead 60 may be connected to leads in the shaft 12 of the guide wire by coupling 40.
  • Coupling 40 may be removable to permit devices such as catheters to be advanced over the proximal end of the guide wire 10.
  • Coupling 40 may also be rotatable to permit the guide wire to be rotated and steered during intravascular navigation.
  • the shaft 12 includes a hypotube 22 which may comprise, for example, stainless steel or a super elastic metal such as a nickel titanium alloy, Nitinol, MP35N, Inconel, etc.
  • the hypotube 22 may extend from the proximal end of the guide wire shaft 12, and may include an outer sleeve 24 comprising a polymer such as polyurethane.
  • a tapered core wire 26 may extend through the lumen in the hypotube 22, and may comprise stainless steel or a super elastic metal such as a nickel titanium alloy, Nitinol, MP35N, Inconel, etc.
  • the distal end of the hypotube 22 in the region of the distal tip 18 may be helically slotted 28 to enhance flexibility.
  • the distal end of the core wire 26 may be welded to the distal end of the slotted portion 28 of the hypotube 22 to form an atraumatic weld ball 30.
  • the distal portion 16 of the guide wire shaft 12 includes a heat source.
  • the heat source comprises a resistive element 32.
  • Resistive element 32 may comprise a tungsten or steel alloy that may be formed into a coil and heated by electro-resistive heating.
  • Heater coil 32 may be disposed between adjacent turns in the slotted portion 28 of the hypotube 22.
  • the resistive heater coil 32 is connected to insultated leads 34 which may be disposed in the lumen of the hypotube 22 around the core wire 26. Leads 34 are connected to coupling 40, which in turn is connected to controller/power supply 50 via lead 60.
  • a polymeric outer tube 36 may be disposed about the resistive heater coil 32, and a polymeric inner tube 38 may be provided to support the heater coil 32.
  • the polymeric outer tube 36 and/or the polymeric inner tube 38 may be formed of a polymer that changes in stiffness when heated.
  • the polymeric outer tube 36 and/or the polymeric inner tube 38 may be formed of a polymer that is relatively stiff at temperatures at or below body temperature (37°C or less) and relatively flexible at temperatures above body temperature.
  • a polymer may be selected with a glass transition temperature (T g ) that is above body temperature, such that heating the polymer above T g results in the distal portion 16 of the guide wire 10 becoming relatively more flexible, and cooling the polymer below T g , even when the guide wire 10 is disposed in the patient's body, results in the distal portion 16 of the guide wire 10 becoming relatively more stiff.
  • the polymeric outer tube 36 and/or the polymeric inner tube 38 may be formed of a shape memory polymer (SMP) such as a shape memory polyurethane available from Mitsubishi.
  • SMPs include polynorbomenes, polycaprolactones and copolymers thereof available from Pnemoscience.
  • Some SMPs, such as polynorbomene may change flexibility without changing temperature across T g .
  • Such SMPs may be above T g at room temperature or body temperature, and may exhibit SMP characteristics at or near the melt temperature (T m ).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Endoscopes (AREA)

Abstract

A guide wire with a distal portion having adjustable flexibility. The guide wire may include a distal polymeric member and a heat source. The heat source may be activated to cause the polymeric member to increase in temperature and increase in flexibility. The increase in flexibility of the distal portion of the guide wire enhances the ability of the guide wire to navigate tortuous vasculature to a target site. After the guide wire has been navigated to the target site, the heat source may be deactivated to cause the polymeric member to decrease in temperature and increase in stiffness. The increase in stiffness of the distal portion of the guide wire enhances support provided for devices (e.g., catheters) advanced thereon.

Description

GUIDE WIRE WITH ADJUSTABLE FLEXIBELITY
Field of the Invention The present invention generally relates to intravascular guide wires. In particular, the present invention relates to intravascular guide wires having adjustable flexibility.
Background of the Invention
Intravascular guide wires are often used to facilitate the delivery of therapeutic and diagnostic devices to remote vascular sites in the human body. In particular, intravascular guide wires are used to navigate through a patient's vasculature from a convenient location outside the patient's body, to a target site inside the patient's body requiring diagnosis and/or therapy. Once access to the target site has been provided by the guide wire, a therapeutic or diagnostic device (e.g., catheter) may then be advanced over the guide wire to the target site, and the desired therapeutic or diagnostic steps may be performed.
To facilitate navigation in tortuous vasculature, it is desirable that the guide wire have a relatively flexible distal end. To provide good support for devices advanced over the guide wire, it is desirable that the guide wire have a relatively stiff distal end. Conventional guide wires typically address these competing needs by establishing a compromise in flexibility and stiffness. However, it would be desirable to have a guide wire that does not compromise these competing needs.
Summary of the Invention
To address these needs, the present invention provides, in one exemplary embodiment, a guide wire that has a distal portion with adjustable flexibility. In one example, the guide wire includes a distal polymeric member and a heat source. The heat source may be activated by a power supply, which causes the polymeric member to increase in temperature, to thereby increase the flexibility of the distal portion of the guide wire. The polymeric member may comprise a shape memory polymer having a glass transition temperature, wherein the increase in temperature is across the glass transition temperature.
The increase in flexibility of the distal portion of the guide wire enhances the ability of the guide wire to navigate vasculature of varying degrees of tortuosity. After the guide wire has been navigated to the target site, the heat source may be deactivated, which causes the polymeric member to decrease in temperature, to thereby increase the stiffness of the distal portion of the guide wire and provide enhanced support for devices advanced thereon.
Brief Description of the Drawings Figure 1 is a plan view of a guide wire system, including a guide wire, a controller/power source and a coupling/lead therebetween, in accordance with an exemplary embodiment of the present invention; and Figure 2 is a longitudinal cross-sectional view taken along line 2 - 2 in Figure
1, illustrating in detail the distal portion of the guide wire shown in Figure 1.
Detailed Description The following description should be read with reference to the drawings wherein like reference numerals indicate like elements throughout the several views. The detailed description and drawings illustrate embodiments by way of example, not limitation.
Refer now to Figure 1 which illustrates a guide wire system in accordance with an exemplary embodiment of the present invention. The guide wire system includes a guide wire 10 connected to a controller and power source 50 by a coupling 40 and lead 60.
Guide wire 10 includes an elongate shaft 12 having a proximal portion 14 and a distal portion 16. Distal portion 16 includes a soft atraumatic tip 18. The proximal portion 14 of the shaft 12 is relatively stiff to provide pushability and torquability, and the distal portion 16 has adjustable flexibility to provide trackability in navigating tortuous vasculature and support for devices advanced thereover.
Except as described herein and implicit in the drawings, the guide wire 10 may have conventional dimensions and may be formed of conventional materials using conventional techniques known for intravascular guide wires used to navigate the human vasculature to remote locations including, but not limited to, the neurovasculature, the coronary vasculature, and the peripheral vasculature.
As will be discussed in more detail with reference to Figure 2, the distal portion 16 of the guide wire 10 includes a heat source that is thermally connected to a polymeric member that increases in flexibility when heated, and increases in stiffness (e.g., returns to its nominal flexibility or stiffness at body temperature) when cooled. Thus, by activating or deactivating the heat source, the flexibility of the polymeric member, and thus the flexibility of the distal portion 16, may be adjusted. For example, the flexibility of the distal portion 16 may be increased by activating the heat source, which enhances the ability of the guide wire 10 to navigate tortuous vasculature to a target site. After the guide wire 10 has been navigated to the desired target site, the heat source may be deactivated to cause the distal portion 16 to increase in stiffness, which enhances guide wire 10 support provided for devices (e.g., catheters) advanced thereon.
To control activation and deactivation of the heat source, a controller/power supply 50 is connected by lead 60 to a coupling 40 which is releasably and rotatably connected to the proximal portion 14 of the guide wire shaft 12. Controller/power supply 50 may comprise a conventional power supply with conventional control circuitry to provide a constant or modulated AC or DC signal. The signal is transmitted by lead 60, which may comprise two (or more) conductors. The conductors in the lead 60 may be connected to leads in the shaft 12 of the guide wire by coupling 40. Coupling 40 may be removable to permit devices such as catheters to be advanced over the proximal end of the guide wire 10. Coupling 40 may also be rotatable to permit the guide wire to be rotated and steered during intravascular navigation.
Refer now to Figure 2 which illustrates in detail certain aspects of the distal portion 16 of the guide wire 10, which may be in common with certain aspects of the proximal portion 14. As seen in Figure 2, the shaft 12 includes a hypotube 22 which may comprise, for example, stainless steel or a super elastic metal such as a nickel titanium alloy, Nitinol, MP35N, Inconel, etc. The hypotube 22 may extend from the proximal end of the guide wire shaft 12, and may include an outer sleeve 24 comprising a polymer such as polyurethane. A tapered core wire 26 may extend through the lumen in the hypotube 22, and may comprise stainless steel or a super elastic metal such as a nickel titanium alloy, Nitinol, MP35N, Inconel, etc. The distal end of the hypotube 22 in the region of the distal tip 18 may be helically slotted 28 to enhance flexibility. The distal end of the core wire 26 may be welded to the distal end of the slotted portion 28 of the hypotube 22 to form an atraumatic weld ball 30. As mentioned previously, the distal portion 16 of the guide wire shaft 12 includes a heat source. In this particular example, the heat source comprises a resistive element 32. Resistive element 32 may comprise a tungsten or steel alloy that may be formed into a coil and heated by electro-resistive heating. Heater coil 32 may be disposed between adjacent turns in the slotted portion 28 of the hypotube 22. The resistive heater coil 32 is connected to insultated leads 34 which may be disposed in the lumen of the hypotube 22 around the core wire 26. Leads 34 are connected to coupling 40, which in turn is connected to controller/power supply 50 via lead 60.
A polymeric outer tube 36 may be disposed about the resistive heater coil 32, and a polymeric inner tube 38 may be provided to support the heater coil 32. The polymeric outer tube 36 and/or the polymeric inner tube 38 may be formed of a polymer that changes in stiffness when heated. For example, the polymeric outer tube 36 and/or the polymeric inner tube 38 may be formed of a polymer that is relatively stiff at temperatures at or below body temperature (37°C or less) and relatively flexible at temperatures above body temperature. For example, a polymer may be selected with a glass transition temperature (Tg) that is above body temperature, such that heating the polymer above Tg results in the distal portion 16 of the guide wire 10 becoming relatively more flexible, and cooling the polymer below Tg, even when the guide wire 10 is disposed in the patient's body, results in the distal portion 16 of the guide wire 10 becoming relatively more stiff. In a preferred embodiment, the polymeric outer tube 36 and/or the polymeric inner tube 38 may be formed of a shape memory polymer (SMP) such as a shape memory polyurethane available from Mitsubishi. Other examples of suitable SMPs include polynorbomenes, polycaprolactones and copolymers thereof available from Pnemoscience. Some SMPs, such as polynorbomene, may change flexibility without changing temperature across Tg. Such SMPs may be above Tg at room temperature or body temperature, and may exhibit SMP characteristics at or near the melt temperature (Tm).
It should be understood that this disclosure is, in many respects, only illustrative. Changes may be made in details, particularly in matters of shape, size, arrangement of parts and order of steps without departing from the scope of the invention. The invention's scope is, of course, defined in the language in which the appended claims are expressed.

Claims

What is claimed is:
1. A variable stiffness guide wire, comprising: a guide wire shaft having a proximal portion and a distal portion, the distal potion having a flexibility; a polymeric member disposed on the distal portion of the shaft, the polymeric member having a first flexibility at a first temperature and a second flexibility at a second temperature, wherein the first temperature is less than the second temperature and the first flexibility is less than the second flexibility; and a heat source disposed on the distal portion of the shaft, the heat source being in thermal communication with the polymeric member, whereby activation of the heat source causes the polymeric member to rise from the first temperature to the second temperature to thereby change the flexibility of the distal portion of the guide wire.
2. A variable stiffness guide wire as in claim 1, wherein the polymeric member comprises a shape memory polymer.
3. A variable stiffness guide wire as in claim 2, wherein the shape memory polymer has a glass transition temperature, and wherein the first temperature is below the glass transition temperature.
4. A variable stiffness guide wire as in claim 3, wherein the second temperature is above the glass transition temperature.
5. A variable stiffness guide wire as in claim 1, wherein the heat source comprises a resistive heating element.
6. A variable stiffness guide wire as in claim 5, wherein the distal portion of the shaft includes a tip portion.
7. A variable stiffness guide wire as in claim 6, wherein the tip portion includes the polymeric member and resistive heating element.
8. A variable stiffness guide wire as in claim 1, wherein the polymeric member comprises a tube.
9. A variable stiffness guide wire as in claim 8, wherein the resistive heating element comprises a coiled wire.
10. A variable stiffness guide wire as in claim 9, furtlier comprising one or more lead wires connected to and extending proximally from the coiled wire.
11. A variable stiffness guide wire as in claim 10, wherein the polymeric tube is disposed on the coiled wire.
12. A variable stiffness guide wire as in claim 11, wherein a core wire extends through the tip portion.
13. A variable stiffness guide wire as in claim 12, wherein the proximal portion of the guide wire shaft includes a hypotube.
14. A variable stiffness guide wire as in claim 13, wherein the distal portion of the guide wire shaft includes a slotted hypotube.
15. A variable stiffness guide wire as in claim 14, wherein the coiled wire is disposed in the slots of the slotted hypotube.
16. A variable stiffness guide wire, comprising: a guide wire shaft including a proximal portion and a distal portion having a flexibility; a polymeric member disposed on the distal portion of the shaft; and a heat source in thermal communication with the polymeric member, whereby activation of the heat source causes the polymeric member to change the flexibility of the distal portion of the guide wire shaft.
17. A variable stiffness guide wire as in claim 16, wherein the polymeric member comprises a shape memory polymer.
18. A variable stiffness guide wire as in claim 17, wherein activation of the heat source causes the shape memory polymer to change temperature.
19. A variable stiffness guide wire as in claim 18, wherein the shape memory polymer has a glass transition temperature, and wherein the change in temperature is across the glass transition temperature.
20. A variable stiffness guide wire as in claim 18, wherein the shape memory polymer has a glass transition temperature, and wherein the change in temperature is near the melt temperature.
21. A variable stiffness guide wire as in claim 16, wherein the heat source comprises a resistive heating element.
22. A variable stiffness guide wire as in claim 21, wherein the distal portion of the shaft includes a tip portion.
23. A variable stiffness guide wire as in claim 22, wherein the tip portion includes the polymeric member and resistive heating element.
24. A variable stiffness guide wire as in claim 23, wherein the polymeric member comprises a tube.
25. A variable stiffness guide wire as in claim 24, wherem the resistive heating element comprises a coiled wire.
26. A variable stiffness guide wire as in claim 25, further comprising one or more lead wires connected to and extending proximally from the coiled wire.
27. A variable stiffness guide wire as in claim 26, wherein the polymeric tube is disposed on the coiled wire.
28. A variable stiffness guide wire as in claim 27, wherein a core wire extends through the tip portion.
29 A variable stiffness guide wire as in claim 28, wherein the proximal portion of the guide wire shaft includes a hypotube.
30. A variable stiffness guide wire as in claim 29, wherein the distal portion of the guide wire shaft includes a slotted hypotube.
31. A variable stiffness guide wire as in claim 30, wherein the coiled wire is disposed in the slots of the slotted hypotube.
32. A variable stiffness guide wire system, comprising: a guide wire including a distal portion having a flexibility, a distal polymeric member, and a heat source in thermal communication with the polymeric member; and a power supply connected to the heat source, whereby activation of the heat source by the power supply causes the polymeric member to change the flexibility of the distal portion of the guide wire.
33. A method of using a variable stiffness guide wire, comprising the steps of: providing a guide wire including a distal portion having a flexibility, a distal polymeric member, and a heat source in thermal communication with the polymeric member; and changing the flexibility of the distal portion of the guide wire by activating or deactivating the heat source.
34. A method of using a variable stiffness guide wire as in claim 33, wherein the flexibility changing step comprises activating the heat source to increase the flexibility of the distal portion of the guide wire, the method further comprising the step of navigating the guide wire through a patient's vasculature to a target site.
35. A method of using a variable stiffness guide wire as in claim 34, further comprising the step of deactivating the heat source to decrease the flexibility of the distal portion of the guide wire.
36. A method of using a variable stiffness guide wire as in claim 35, further comprising the step of advancing a device over the guide wire to the target site.
37. A method of using a variable stiffness guide wire as in claim 33, wherem the polymeric member comprises a shape memory polymer having a glass transition temperature, and wherein the flexibility changing step comprises heating the polymeric member near the melt temperature.
38. A method of using a variable stiffness guide wire as in claim 33, wherein the polymeric member comprises a shape memory polymer having a glass transition temperature, and wherein the flexibility changing step comprises heating the polymeric member above the glass transition temperature.
39. A method of using a variable stiffness guide wire as in claim 33, wherein the heat source comprises a resistive heating element, and wherein the activating step comprises supplying electrical energy to the resistive heating element.
EP02776024A 2001-12-18 2002-09-26 Guide wire with adjustable flexibility Expired - Lifetime EP1455881B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25428 1998-02-18
US10/025,428 US7018346B2 (en) 2001-12-18 2001-12-18 Guide wire with adjustable flexibility
PCT/US2002/030771 WO2003051445A1 (en) 2001-12-18 2002-09-26 Guide wire with adjustable flexibility

Publications (2)

Publication Number Publication Date
EP1455881A1 true EP1455881A1 (en) 2004-09-15
EP1455881B1 EP1455881B1 (en) 2008-12-03

Family

ID=21825993

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02776024A Expired - Lifetime EP1455881B1 (en) 2001-12-18 2002-09-26 Guide wire with adjustable flexibility

Country Status (8)

Country Link
US (2) US7018346B2 (en)
EP (1) EP1455881B1 (en)
JP (1) JP4276544B2 (en)
AT (1) ATE415999T1 (en)
AU (1) AU2002341869A1 (en)
CA (1) CA2470598A1 (en)
DE (1) DE60230183D1 (en)
WO (1) WO2003051445A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7018346B2 (en) * 2001-12-18 2006-03-28 Scimed Life Systems, Inc. Guide wire with adjustable flexibility
EP1765158B1 (en) * 2004-05-25 2017-08-09 U.S. Endoscopy Group, Inc. Delivery device
GB0414222D0 (en) * 2004-06-24 2004-07-28 Univ Cardiff pH sensor
US7989042B2 (en) * 2004-11-24 2011-08-02 Boston Scientific Scimed, Inc. Medical devices with highly flexible coated hypotube
US7828790B2 (en) 2004-12-03 2010-11-09 Boston Scientific Scimed, Inc. Selectively flexible catheter and method of use
US8876772B2 (en) 2005-11-16 2014-11-04 Boston Scientific Scimed, Inc. Variable stiffness shaft
US20070293857A1 (en) * 2006-06-16 2007-12-20 Wilson-Cook Medical Inc. Wire Guide Sphincterotome
US20090118675A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Elongate medical device with a shapeable tip
US7998089B2 (en) * 2007-11-08 2011-08-16 Radi Medical Systems Ab Method of making a guide wire based assembly and reusing an energy source
US8663096B2 (en) * 2007-11-13 2014-03-04 Covidien Lp System and method for rigidizing flexible medical implements
US8246575B2 (en) 2008-02-26 2012-08-21 Tyco Healthcare Group Lp Flexible hollow spine with locking feature and manipulation structure
US20110015490A1 (en) * 2008-03-20 2011-01-20 Koninklijke Philips Electronics N.V. Method and system for cannula positioning
US20090275862A1 (en) * 2008-04-30 2009-11-05 Cook Incorporated Guidewire and method of making same
US20100101295A1 (en) * 2008-10-28 2010-04-29 Warsaw Orthopedic, Inc. Isulated sheath for bending polymer-based rod
US20100168858A1 (en) * 2008-12-30 2010-07-01 Mitchell Hardenbrook Expandable interbody implant and method
US20100228150A1 (en) * 2009-03-05 2010-09-09 Lake Region Medical, Inc. Neuro guidewire
US9295812B2 (en) * 2011-07-28 2016-03-29 Wright-Ahn Technologies, Llc Variable stiffness guidewire systems and methods
US9066828B2 (en) 2012-06-15 2015-06-30 Trivascular, Inc. Endovascular delivery system with flexible and torqueable hypotube
US10835183B2 (en) 2013-07-01 2020-11-17 Zurich Medical Corporation Apparatus and method for intravascular measurements
JP5976983B1 (en) 2013-07-01 2016-08-24 ズーリック・メディカル・コーポレイションＺｕｒｉｃｈ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ Apparatus and method for intravascular measurement
CN106573125B (en) * 2014-06-18 2020-05-22 皇家飞利浦有限公司 Elongated interventional device with variable stiffness
WO2017147041A1 (en) * 2016-02-22 2017-08-31 Arizona Board Of Regents On Behalf Of Arizona State University Adjustable guidewire
US11278701B2 (en) 2016-10-13 2022-03-22 Lake Region Manufacturing, Inc. Apparatus including multiple joined hypotubes and method of making same
US10953204B2 (en) 2017-01-09 2021-03-23 Boston Scientific Scimed, Inc. Guidewire with tactile feel
CN111163831A (en) * 2017-09-14 2020-05-15 W.L.戈尔及同仁股份有限公司 Variable stiffness guidewire

Family Cites Families (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416531A (en) 1964-01-02 1968-12-17 Edwards Miles Lowell Catheter
US3485234A (en) 1966-04-13 1969-12-23 Cordis Corp Tubular products and method of making same
US3612058A (en) 1968-04-17 1971-10-12 Electro Catheter Corp Catheter stylets
US3612038A (en) 1969-02-03 1971-10-12 Becton Dickinson Co Preformable catheter package assembly and method of preforming
US3725116A (en) * 1969-07-09 1973-04-03 Ppg Industries Inc Method of coating with acryloxy esters of anhydrides
US4210478A (en) 1973-05-08 1980-07-01 International Paper Company Method of making a catheter
US4359453A (en) 1978-04-07 1982-11-16 Gordon Robert T Atherosclerosis treatment method
US4341218A (en) 1978-05-30 1982-07-27 University Of California Detachable balloon catheter
DE2830953A1 (en) * 1978-07-14 1980-01-24 Bayer Ag AMMONIUM SALTS OF ALPHA KETOCARBONIC ACIDS
US4292270A (en) 1979-06-22 1981-09-29 Baxter Travenol Laboratories, Inc. Method and apparatus for making coude catheters
US4385635A (en) * 1980-04-25 1983-05-31 Ruiz Oscar F Angiographic catheter with soft tip end
US4588399A (en) * 1980-05-14 1986-05-13 Shiley Incorporated Cannula with radiopaque tip
US4419095A (en) 1980-05-14 1983-12-06 Shiley, Inc. Cannula with radiopaque tip
JPS5812637A (en) 1981-07-13 1983-01-24 オリンパス光学工業株式会社 Apparatus for erecting treating tool of endoscope
US4690175A (en) 1981-11-17 1987-09-01 Kabushiki Kaisha Medos Kenkyusho Flexible tube for endoscope
JPS5886129A (en) * 1981-11-17 1983-05-23 旭光学工業株式会社 Flexible tube of endoscope and production thereof
US4516972A (en) * 1982-01-28 1985-05-14 Advanced Cardiovascular Systems, Inc. Guiding catheter and method of manufacture
SE445884B (en) * 1982-04-30 1986-07-28 Medinvent Sa DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION
US4516970A (en) * 1982-09-13 1985-05-14 Kaufman Jack W Medical device
US4651751A (en) 1982-10-14 1987-03-24 American Hospital Supply Corporation Guiding catheter and method of use
US4622953A (en) 1983-01-13 1986-11-18 Gordon Robert T Process for the treatment of atherosclerotic lesions
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
US4563181A (en) * 1983-02-18 1986-01-07 Mallinckrodt, Inc. Fused flexible tip catheter
US4531943A (en) 1983-08-08 1985-07-30 Angiomedics Corporation Catheter with soft deformable tip
US4590922A (en) * 1983-08-19 1986-05-27 Gordon Robert T Use of ferromagnetic, paramagnetic and diamagnetic particles in the treatment of infectious diseases
US4672962A (en) * 1983-09-28 1987-06-16 Cordis Corporation Plaque softening method
US5090956A (en) 1983-10-31 1992-02-25 Catheter Research, Inc. Catheter with memory element-controlled steering
US5055101A (en) 1983-10-31 1991-10-08 Catheter Research, Inc. Variable shape guide apparatus
US6017335A (en) 1983-12-12 2000-01-25 Burnham; Warren R. Method for making a tubular product, especially a catheter, and article made thereby
JPS60126170A (en) * 1983-12-14 1985-07-05 テルモ株式会社 Catheter and its production
US4627436A (en) 1984-03-01 1986-12-09 Innoventions Biomedical Inc. Angioplasty catheter and method for use thereof
US4747405A (en) * 1984-03-01 1988-05-31 Vaser, Inc. Angioplasty catheter
US4685458A (en) 1984-03-01 1987-08-11 Vaser, Inc. Angioplasty catheter and method for use thereof
US4636346A (en) * 1984-03-08 1987-01-13 Cordis Corporation Preparing guiding catheter
US4767611A (en) 1984-07-03 1988-08-30 Gordon Robert T Method for affecting intracellular and extracellular electric and magnetic dipoles
US4705511A (en) 1985-05-13 1987-11-10 Bipore, Inc. Introducer sheath assembly
US4654024A (en) * 1985-09-04 1987-03-31 C.R. Bard, Inc. Thermorecanalization catheter and method for use
US4748979A (en) * 1985-10-07 1988-06-07 Cordis Corporation Plaque resolving device
US4643186A (en) * 1985-10-30 1987-02-17 Rca Corporation Percutaneous transluminal microwave catheter angioplasty
JPS62140385A (en) * 1985-12-16 1987-06-23 三理株式会社 Quick heating unit
US4735620A (en) * 1986-01-16 1988-04-05 Ruiz Oscar F Non-whip catheter
US4728322A (en) * 1986-02-05 1988-03-01 Menlo Care, Inc. Adjustable catheter assembly
JPS62261371A (en) * 1986-05-08 1987-11-13 テルモ株式会社 Catheter
US4740574A (en) * 1986-05-09 1988-04-26 E. I. Du Pont De Nemours And Company Aluminum nitride structures
US4790311A (en) 1986-06-03 1988-12-13 Ruiz Oscar F Radio frequency angioplasty catheter system
US4923437A (en) * 1986-07-18 1990-05-08 Gordon Robert T Process for applying a localized magnetic or electric field
US4753223A (en) 1986-11-07 1988-06-28 Bremer Paul W System for controlling shape and direction of a catheter, cannula, electrode, endoscope or similar article
EP0277366A1 (en) 1987-01-06 1988-08-10 Advanced Cardiovascular Systems, Inc. Guiding catheter assembly and method for making it
US4869248A (en) 1987-04-17 1989-09-26 Narula Onkar S Method and apparatus for localized thermal ablation
US5211183A (en) 1987-05-13 1993-05-18 Wilson Bruce C Steerable memory alloy guide wires
US5143085A (en) 1987-05-13 1992-09-01 Wilson Bruce C Steerable memory alloy guide wires
US5025799A (en) 1987-05-13 1991-06-25 Wilson Bruce C Steerable memory alloy guide wires
US4838859A (en) 1987-05-19 1989-06-13 Steve Strassmann Steerable catheter
US4807620A (en) * 1987-05-22 1989-02-28 Advanced Interventional Systems, Inc. Apparatus for thermal angioplasty
US4817613A (en) * 1987-07-13 1989-04-04 Devices For Vascular Intervention, Inc. Guiding catheter
US4863442A (en) 1987-08-14 1989-09-05 C. R. Bard, Inc. Soft tip catheter
US4840622A (en) * 1987-10-06 1989-06-20 Menlo Care, Inc. Kink resistant catheter
US5041089A (en) 1987-12-11 1991-08-20 Devices For Vascular Intervention, Inc. Vascular dilation catheter construction
US4895168A (en) * 1988-01-21 1990-01-23 Schneider (Usa) Inc., A Pfizer Company Guidewire with movable core and external tubular safety cover
JP2561853B2 (en) 1988-01-28 1996-12-11 株式会社ジェイ・エム・エス Shaped memory molded article and method of using the same
US4930494A (en) * 1988-03-09 1990-06-05 Olympus Optical Co., Ltd. Apparatus for bending an insertion section of an endoscope using a shape memory alloy
US5078702A (en) * 1988-03-25 1992-01-07 Baxter International Inc. Soft tip catheters
US5116317A (en) * 1988-06-16 1992-05-26 Optimed Technologies, Inc. Angioplasty catheter with integral fiber optic assembly
US5249585A (en) 1988-07-28 1993-10-05 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US4898591A (en) * 1988-08-09 1990-02-06 Mallinckrodt, Inc. Nylon-PEBA copolymer catheter
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
US4981478A (en) * 1988-09-06 1991-01-01 Advanced Cardiovascular Systems Composite vascular catheter
US4984581A (en) 1988-10-12 1991-01-15 Flexmedics Corporation Flexible guide having two-way shape memory alloy
US5017259A (en) * 1988-10-13 1991-05-21 Terumo Kabushiki Kaisha Preparation of catheter including bonding and then thermoforming
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US4985022A (en) 1988-11-23 1991-01-15 Med Institute, Inc. Catheter having durable and flexible segments
US5257635A (en) 1988-11-25 1993-11-02 Sensor Electronics, Inc. Electrical heating catheter
US5203772A (en) 1989-01-09 1993-04-20 Pilot Cardiovascular Systems, Inc. Steerable medical device
EP0382974A1 (en) 1989-01-23 1990-08-22 C.R. Bard, Inc. Braided guide wire and method for the use thereof
CA2030786C (en) 1989-04-13 1997-04-01 Atsushi Utsumi Catheter
US5009655A (en) 1989-05-24 1991-04-23 C. R. Bard, Inc. Hot tip device with optical diagnostic capability
US5019040A (en) * 1989-08-31 1991-05-28 Koshin Sangyo Kabushiki Kaisha Catheter
NL8902286A (en) 1989-09-13 1991-04-02 Cordis Europ DRAINAGE CATHETER AND METHOD FOR MANUFACTURING THAT.
US5217440A (en) 1989-10-06 1993-06-08 C. R. Bard, Inc. Multilaminate coiled film catheter construction
US5176660A (en) * 1989-10-23 1993-01-05 Cordis Corporation Catheter having reinforcing strands
EP0434334B1 (en) 1989-12-21 1994-02-02 Minnesota Mining And Manufacturing Company Dental compositions, a method of making shaped dental articals via photoiniferter polymerization of the dental compositions, and shaped dental articles produced thereby
US5093385A (en) * 1989-12-21 1992-03-03 Minnesota Mining And Manufacturing Company Method of accelerating photoiniferter polymerization, polymer produced thereby, and product produced therewith
US5047025A (en) 1990-01-12 1991-09-10 Metcal, Inc. Thermal atherectomy device
US5057092A (en) 1990-04-04 1991-10-15 Webster Wilton W Jr Braided catheter with low modulus warp
NL9000833A (en) 1990-04-09 1991-11-01 Cordis Europ ANGIOGRAPHY CATHETER.
US5098429A (en) * 1990-04-17 1992-03-24 Mmtc, Inc. Angioplastic technique employing an inductively-heated ferrite material
US5180376A (en) * 1990-05-01 1993-01-19 Cathco, Inc. Non-buckling thin-walled sheath for the percutaneous insertion of intraluminal catheters
US5190540A (en) * 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
US5433200A (en) 1990-07-09 1995-07-18 Lake Region Manufacturing, Inc. Low profile, coated, steerable guide wire
US5279596A (en) * 1990-07-27 1994-01-18 Cordis Corporation Intravascular catheter with kink resistant tip
JPH0447402U (en) 1990-08-24 1992-04-22
US5190520A (en) * 1990-10-10 1993-03-02 Strato Medical Corporation Reinforced multiple lumen catheter
US5160559A (en) 1990-10-31 1992-11-03 Scimed Life Systems, Inc. Method for forming a guide catheter tip bond
US6387052B1 (en) * 1991-01-29 2002-05-14 Edwards Lifesciences Corporation Thermodilution catheter having a safe, flexible heating element
US5156596A (en) 1991-02-04 1992-10-20 Menlo Care, Inc. Catheter with changeable number of lumens
US5254107A (en) 1991-03-06 1993-10-19 Cordis Corporation Catheter having extended braid reinforced transitional tip
US5234416A (en) 1991-06-06 1993-08-10 Advanced Cardiovascular Systems, Inc. Intravascular catheter with a nontraumatic distal tip
US5221270A (en) 1991-06-28 1993-06-22 Cook Incorporated Soft tip guiding catheter
NL9101159A (en) 1991-07-03 1993-02-01 Industrial Res Bv FORMATTABLE EXPANDABLE RING, CYLINDER OR SLEEVE.
CA2073750C (en) * 1991-07-18 1996-11-12 Toshiaki Yutori Catheter guide wire and catheter
US5222949A (en) 1991-07-23 1993-06-29 Intermed, Inc. Flexible, noncollapsible catheter tube with hard and soft regions
US5308342A (en) * 1991-08-07 1994-05-03 Target Therapeutics, Inc. Variable stiffness catheter
US5335305A (en) 1991-12-19 1994-08-02 Optex Biomedical, Inc. Optical sensor for fluid parameters
US6179824B1 (en) * 1993-05-10 2001-01-30 Arthrocare Corporation System and methods for electrosurgical restenosis of body lumens
US5318032A (en) 1992-02-05 1994-06-07 Devices For Vascular Intervention Guiding catheter having soft tip
US5221372A (en) 1992-02-13 1993-06-22 Northwestern University Fracture-tough, high hardness stainless steel and method of making same
US5578008A (en) 1992-04-22 1996-11-26 Japan Crescent, Inc. Heated balloon catheter
US5290230A (en) * 1992-05-11 1994-03-01 Advanced Cardiovascular Systems, Inc. Intraluminal catheter with a composite shaft
US5349946A (en) 1992-10-07 1994-09-27 Mccomb R Carter Microprocessor controlled flow regulated molecular humidifier
US6090072A (en) * 1992-10-15 2000-07-18 Scimed Life Systems, Inc. Expandable introducer sheath
EP0746373A1 (en) 1992-12-01 1996-12-11 Intelliwire, Inc. Vibratory element for crossing stenoses
US5358493A (en) 1993-02-18 1994-10-25 Scimed Life Systems, Inc. Vascular access catheter and methods for manufacture thereof
US5370109A (en) 1993-02-19 1994-12-06 United States Surgical Corporation Deformable endoscopic surgical retractor
US5538512A (en) 1993-02-25 1996-07-23 Zenzon; Wendy J. Lubricious flow directed catheter
NL9300500A (en) 1993-03-22 1994-10-17 Industrial Res Bv Expandable hollow sleeve for locally supporting and / or strengthening a body vessel, as well as a method for manufacturing it.
EP0696176B1 (en) * 1993-04-28 2002-07-03 Biosense Webster, Inc. Electrophysiology catheter with pre-curved tip
US5349964A (en) * 1993-05-05 1994-09-27 Intelliwire, Inc. Device having an electrically actuatable section with a portion having a current shunt and method
US5769796A (en) 1993-05-11 1998-06-23 Target Therapeutics, Inc. Super-elastic composite guidewire
US5531715A (en) 1993-05-12 1996-07-02 Target Therapeutics, Inc. Lubricious catheters
US5531685A (en) 1993-06-11 1996-07-02 Catheter Research, Inc. Steerable variable stiffness device
US5334168A (en) 1993-06-11 1994-08-02 Catheter Research, Inc. Variable shape guide apparatus
US5502087A (en) * 1993-06-23 1996-03-26 Dentsply Research & Development Corp. Dental composition, prosthesis, and method for making dental prosthesis
US5954651A (en) 1993-08-18 1999-09-21 Scimed Life Systems, Inc. Catheter having a high tensile strength braid wire constraint
DE4428914C2 (en) 1993-08-18 2000-09-28 Scimed Life Systems Inc Thin-walled multi-layer catheter
US5951495A (en) 1993-12-22 1999-09-14 Scimed Life Systems, Inc. Catheter having an adhesive braid wire constraint and method of manufacture
US5443495A (en) 1993-09-17 1995-08-22 Scimed Lifesystems Inc. Polymerization angioplasty balloon implant device
WO1995010321A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Creating curvilinear lesions in body tissue
JPH09507399A (en) 1993-11-12 1997-07-29 マイクロ インターベンショナル システムズ Catheter with small diameter and high torque
CA2135143C (en) * 1993-12-22 2006-01-03 Todd A. Berg Catheter joint with restraining device
US5423773A (en) 1994-01-21 1995-06-13 Exonix Research Corp. Catheter with gear body and progressively compliant tip
US5445624A (en) 1994-01-21 1995-08-29 Exonix Research Corporation Catheter with progressively compliant tip
US5911715A (en) 1994-02-14 1999-06-15 Scimed Life Systems, Inc. Guide catheter having selected flexural modulus segments
US5569218A (en) 1994-02-14 1996-10-29 Scimed Life Systems, Inc. Elastic guide catheter transition element
US5511547A (en) * 1994-02-16 1996-04-30 Biomedical Sensors, Ltd. Solid state sensors
US5509910A (en) * 1994-05-02 1996-04-23 Medtronic, Inc. Method of soft tip attachment for thin walled catheters
US5423774A (en) 1994-05-17 1995-06-13 Arrow International Investment Corp. Introducer sheath with irregular outer surface
US5665063A (en) 1994-06-24 1997-09-09 Focal, Inc. Methods for application of intraluminal photopolymerized gels
US5497786A (en) 1994-08-18 1996-03-12 Scimed Life Systems, Inc. Apparatus and method for formable guide wire tip
US5599319A (en) * 1994-09-01 1997-02-04 Cordis Corporation Soft flexible catheter tip for use in angiography
US5514108A (en) * 1994-09-01 1996-05-07 Cordis Corporation Soft flexible catheter tip for use in angiography
US5938623A (en) 1994-10-28 1999-08-17 Intella Interventional Systems Guide wire with adjustable stiffness
US5545151A (en) 1994-11-22 1996-08-13 Schneider (Usa) Inc Catheter having hydrophobic properties
US6027450A (en) * 1994-12-30 2000-02-22 Devices For Vascular Intervention Treating a totally or near totally occluded lumen
NL9500493A (en) 1995-03-13 1996-10-01 Cordis Europ Catheter with light guide.
NL9500516A (en) * 1995-03-15 1996-10-01 Cordis Europ Balloon catheter with light-guiding basic body.
US5662622A (en) * 1995-04-04 1997-09-02 Cordis Corporation Intravascular catheter
US5658263A (en) 1995-05-18 1997-08-19 Cordis Corporation Multisegmented guiding catheter for use in medical catheter systems
US5591199A (en) * 1995-06-07 1997-01-07 Porter; Christopher H. Curable fiber composite stent and delivery system
US5779673A (en) 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
US5662621A (en) * 1995-07-06 1997-09-02 Scimed Life Systems, Inc. Guide catheter with shape memory retention
US5800500A (en) * 1995-08-18 1998-09-01 Pi Medical Corporation Cochlear implant with shape memory material and method for implanting the same
US5891094A (en) * 1995-09-07 1999-04-06 Innerdyne, Inc. System for direct heating of fluid solution in a hollow body organ and methods
US20030069522A1 (en) * 1995-12-07 2003-04-10 Jacobsen Stephen J. Slotted medical device
US5772628A (en) 1996-02-13 1998-06-30 Imagyn Medical, Inc. Surgical access device and method of constructing same
NL1002423C2 (en) 1996-02-22 1997-08-25 Cordis Europ Temporary filter catheter.
US5830224A (en) 1996-03-15 1998-11-03 Beth Israel Deaconess Medical Center Catheter apparatus and methodology for generating a fistula on-demand between closely associated blood vessels at a pre-chosen anatomic site in-vivo
US5997526A (en) 1996-03-25 1999-12-07 The Uab Research Foundation Shape memory catheter
US5836925A (en) 1996-04-03 1998-11-17 Soltesz; Peter P. Catheter with variable flexibility properties and method of manufacture
US5931819A (en) 1996-04-18 1999-08-03 Advanced Cardiovascular Systems, Inc. Guidewire with a variable stiffness distal portion
US6042578A (en) * 1996-05-13 2000-03-28 Schneider (Usa) Inc. Catheter reinforcing braids
US6090099A (en) 1996-05-24 2000-07-18 Target Therapeutics, Inc. Multi-layer distal catheter section
US6072154A (en) 1996-09-05 2000-06-06 Medtronic, Inc. Selectively activated shape memory device
US6197844B1 (en) * 1996-09-13 2001-03-06 3M Innovative Properties Company Floor finish compositions
SI0901341T1 (en) 1997-01-03 2005-04-30 Biosense Webster, Inc. Bend-responsive catheter
US5911737A (en) 1997-02-28 1999-06-15 The Regents Of The University Of California Microfabricated therapeutic actuators
US6017323A (en) * 1997-04-08 2000-01-25 Target Therapeutics, Inc. Balloon catheter with distal infusion section
US6165166A (en) 1997-04-25 2000-12-26 Schneider (Usa) Inc. Trilayer, extruded medical tubing and medical devices incorporating such tubing
US5810867A (en) * 1997-04-28 1998-09-22 Medtronic, Inc. Dilatation catheter with varied stiffness
US6056844A (en) * 1997-06-06 2000-05-02 Triton Systems, Inc. Temperature-controlled induction heating of polymeric materials
US5971979A (en) 1997-12-02 1999-10-26 Odyssey Technologies, Inc. Method for cryogenic inhibition of hyperplasia
US6240231B1 (en) * 1997-12-22 2001-05-29 Micrus Corporation Variable stiffness fiber optic shaft
US6562021B1 (en) * 1997-12-22 2003-05-13 Micrus Corporation Variable stiffness electrically conductive composite, resistive heating catheter shaft
JP2001526926A (en) * 1997-12-31 2001-12-25 ファーマソニックス，インコーポレイテッド Methods and systems for suppressing vascular hyperplasia
US5957966A (en) 1998-02-18 1999-09-28 Intermedics Inc. Implantable cardiac lead with multiple shape memory polymer structures
ATE327287T1 (en) * 1998-02-23 2006-06-15 Mnemoscience Gmbh SHAPE MEMORY POLYMER
EP0947223B1 (en) 1998-04-04 2003-03-12 Job Lizenz GmbH & Co. KG Tensile cable shortening for fire fighting equipment
US6102917A (en) 1998-07-15 2000-08-15 The Regents Of The University Of California Shape memory polymer (SMP) gripper with a release sensing system
US6006756A (en) 1998-08-03 1999-12-28 Shadduck; John H. Non-contact magnetoresonant implant system and techniques for periodic corneal re-shaping
US6428563B1 (en) 2000-01-21 2002-08-06 Radiant Medical, Inc. Heat exchange catheter with improved insulated region
US6224610B1 (en) * 1998-08-31 2001-05-01 Micrus Corporation Shape memory polymer intravascular delivery system with heat transfer medium
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6290692B1 (en) 1998-11-03 2001-09-18 Daniel J. Klima Catheter support structure
US6086599A (en) 1999-02-08 2000-07-11 The Regents Of The University Of California Micro devices using shape memory polymer patches for mated connections
US6468297B1 (en) 1999-02-24 2002-10-22 Cryovascular Systems, Inc. Cryogenically enhanced intravascular interventions
US6428534B1 (en) 1999-02-24 2002-08-06 Cryovascular Systems, Inc. Cryogenic angioplasty catheter
US6258195B1 (en) 1999-03-19 2001-07-10 Scimed Life Systems, Inc. Multi-cord fusing manufacturing process for catheter members
US6555288B1 (en) * 1999-06-21 2003-04-29 Corning Incorporated Optical devices made from radiation curable fluorinated compositions
US6323251B1 (en) 1999-09-24 2001-11-27 3M Innovative Properties Co Thermoplastic/thermoset hybrid foams and methods for making same
US6533752B1 (en) * 2000-01-05 2003-03-18 Thomas C Waram Variable shape guide apparatus
US6520952B1 (en) * 2000-03-23 2003-02-18 Neich Medical Co., Ltd. Ceramic reinforced catheter
EP1285012B1 (en) 2000-05-26 2007-01-10 Akzo Nobel Coatings International B.V. Photoactivatable coating composition
US6626905B1 (en) * 2000-08-02 2003-09-30 Sulzer Spine-Tech Inc. Posterior oblique lumbar arthrodesis
US6485512B1 (en) 2000-09-27 2002-11-26 Advanced Cardiovascular Systems, Inc. Two-stage light curable stent and delivery system
US6740094B2 (en) * 2000-11-06 2004-05-25 The Regents Of The University Of California Shape memory polymer actuator and catheter
US7018371B2 (en) 2001-05-07 2006-03-28 Xoft, Inc. Combination ionizing radiation and radiosensitizer delivery devices and methods for inhibiting hyperplasia
US7018346B2 (en) * 2001-12-18 2006-03-28 Scimed Life Systems, Inc. Guide wire with adjustable flexibility
US6740107B2 (en) * 2001-12-19 2004-05-25 Trimedyne, Inc. Device for treatment of atrioventricular valve regurgitation
US6945970B2 (en) 2001-12-27 2005-09-20 Scimed Life Systems, Inc. Catheter incorporating a curable polymer layer to control flexibility and method of manufacture
GB0219779D0 (en) * 2002-08-23 2002-10-02 Smiths Group Plc Embryo transfer catheters
US7309318B2 (en) * 2002-09-18 2007-12-18 Boston Scientific Scimed, Inc. Flexible composite guidewire for intravascular catheter
US7378048B2 (en) 2002-12-03 2008-05-27 Boston Scientific Scimed, Inc. Method for forming catheter curves
US7828790B2 (en) * 2004-12-03 2010-11-09 Boston Scientific Scimed, Inc. Selectively flexible catheter and method of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO03051445A1 *

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US7018346B2 (en) 2006-03-28
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US20060127561A1 (en) 2006-06-15
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US7918806B2 (en) 2011-04-05
JP2005528931A (en) 2005-09-29
CA2470598A1 (en) 2003-06-26

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