EP1453817A1 - Thiazole derivatives with fungicidal activity - Google Patents
Thiazole derivatives with fungicidal activityInfo
- Publication number
- EP1453817A1 EP1453817A1 EP02795153A EP02795153A EP1453817A1 EP 1453817 A1 EP1453817 A1 EP 1453817A1 EP 02795153 A EP02795153 A EP 02795153A EP 02795153 A EP02795153 A EP 02795153A EP 1453817 A1 EP1453817 A1 EP 1453817A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- group
- optionally substituted
- branched
- linear
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Definitions
- the present invention relates to new thiazole derivatives.
- the present invention relates to new thiazole derivatives having high fungicidal activity, the process for their preparation, and their use for the control of phytopathogenic fungi, in particular in the agrarian field.
- Strobilurines are fungal metabolites chemically characterized by the presence of the group 1- r ⁇ ethoxycarbonyl-2-methoxyethen-l-yl ("Pesticide Science", 1991, page 499) .
- the Applicant has now found new analogous products of strobilurines, chemically characterized by the presence of a 4-thiazole group, having a good stability and surprisingly high fungicidal activity with respect to phytopathogenic fungi, together with a good selectivity towards the vegetables to which they are applied.
- the object of the present invention therefore relates to compounds having general formula (I) :
- Ri represents a hydrogen atom; a linear or branched C ⁇ -C 6 alkyl or haloalkyl group, optionally substituted; a C 2 -C 6 alkenyl or haloalkenyl group, optionally substituted; a C 2 -
- R 2 represents a hydrogen atom; a halogen atom selected from chlorine, fluorine, bromine or iodine; a linear or branched C ⁇ -C 6 alkyl or haloalkyl group, optionally substituted; a linear or branched C 2 -C 6 alkenyl or haloalkenyl group, optionally substituted; a linear or branched C 2 -C 3 alkynyl or haloalkynyl group, optionally substituted; a C 3 -C 6 cycloalkyl group, optionally substituted; a linear or branched Ci- C 6 alkoxy or haloal
- R 3 and R 4 independently represent a linear or branched C 1 -C 4 alkyl group
- R 5 represents a halogen atom, optionally selected from fluorine, chlorine, bromine or iodine; a linear or branched Ci-C ⁇ haloalkyl group, optionally substituted; a linear or branched C ⁇ -C 6 alkoxy group, optionally substituted; a linear or branched C ⁇ -C 6 haloalkoxy group, optionally substituted; a linear or branched C ⁇ -C 6 alkylthio group, optionally substituted; a linear or branched Ci- C 6 haloalkylthio group, optionally substituted; a C 3 -C 6 cycloalkyl group optionally substituted; a linear or branched C 2 -C 8 alkoxycarbonyl group; a cyano group; when R x represents a linear or branched C ⁇ -C 6 haloalkyl group, substituted by at least two halogen atoms, the same
- R 5 also represents a linear or branched Ci-Ce alkyl group, optionally substituted;
- Y represents an oxygen atom; an NH group;
- Z represents a nitrogen atom or a CH group;
- n is a number ranging from 0 to 4.
- Ri represents a hydrogen atom; a linear or branched C ⁇ -C 3 alkyl or haloalkyl group, optionally substituted; a C 2 -C 6 alkenyl or haloalkenyl group, optionally substituted; a C 2 - C 6 alkynyl or haloalkynyl group, optionally substituted; a C 3 -C 6 cycloalkyl group, optionally substituted; an aryl group, optionally substituted; a heteroaryl group, optionally substituted; a heterocyclic group, optionally substituted; a halogen atom;
- R 2 represents a hydrogen atom; a halogen atom selected from chlorine, fluorine, bromine or iodine; a linear or branched C ⁇ -C 6 alkyl or haloalkyl group, optionally substituted; a linear or branched C 2 -C 6 alkenyl or haloalkenyl group, obtionally substituted; a linear or branched C 2 ⁇ C 6 alkynyl or haloalkynyl group, optionally substituted; a C 3 -C 6 cycloalkyl group, optionally substituted; a linear or branched C ⁇ C 6 alkoxy or haloalkoxy group, optionally substituted; a linear or branched C ⁇ -C 6 alkylthio or haloalkylthio group, optionally substituted; a C 3 -C 6 cycloalkoxy group, optionally substituted; a cyano group; a linear or branched C 2 -C 8
- R 5 represents a halogen atom, optionally selected from fluorine, chlorine, bromine or iodine; a linear or branched C ⁇ -C 6 haloalkyl group, optionally substituted; a linear or branched C ⁇ -C 6 alkoxy group, optionally substituted; a linear or branched C ⁇ -C 6 haloalkoxy group, optionally substituted; a linear or branched C ⁇ -C 6 alkylthio group, optionally substituted; a linear or branched Ci- C 6 haloalkylthio group, optionally substituted; a C 3 -C 6 cycloalkyl group, optionally substituted; a linear or branched C 2 -C 8 alkoxycarbonyl group; a cyano group; when R x represents a linear or branched C ⁇ -C 6 haloalkyl group substituted by at least two halogen atoms, the
- R 5 also represents a linear or branched C ⁇ -C 6 alkyl group, optionally substituted;
- Y represents an oxygen atom; an NH group;
- Z represents a nitrogen atom or a CH group;
- n is a number ranging from 0 to 4, he control of phytopathogenic fungi.
- the use of the compounds having formula (I) for the control of phytopathogenic fungi is curative and/or preventive.
- the Ri group is preferably selected from a linear or branched Ci- C 6 alkyl or haloalkyl group, optionally substituted; a C 3 ⁇ C 6 cycloalkyl group, optionally substituted; an aryl group, optionally substituted; a heteroaryl group, optionally substituted.
- the R 2 group is preferably selected from a hydrogen atom; a halogen atom; a linear or branched Ci-Ce alkyl or haloalkyl group, optionally substituted; a C 3 -C 6 cycloalkyl group, optionally substituted; a linear or branched C 2 -C 8 alkoxycarbonyl group, optionally substituted.
- R 3 and R 4 are preferably equal to a methyl group, whereas R 5 is preferably selected from a halogen atom, a C ⁇ -C 6 haloalkyl group or, when Ri represents a Ci-C ⁇ haloalkyl group, R 5 preferably represents a linear or branched C ⁇ -C 6 alkyl group, optionally substituted.
- n is preferably equal to 0 or 1
- Z is preferably equal to CH and Y is preferably an oxygen atom.
- a C ⁇ -C 6 alkyl group refers to a linear or branched C ⁇ -C 6 alkyl group.
- Ci-C ⁇ haloalkyl group refers to a linear or branched alkyl group substituted by one or more halogen atoms, the same or different.
- a polyhaloalkyl group refers to a haloalkyl group substituted by at least two halogen atoms, the same or different.
- Examples of this group are: fluoromethyl, chlorodifluoro ethyl, difluoromethyl, trifluoro- methyl, trichloro ethyl, 2, 2, 2-trifluoroethyl, 2,2,2- trichloroethyl, 1, 1, 2, 2, 2-pentafluoroethyl, 1,1,2,2- tetrafluoroethyl, 1, 2, 2, 2-tetrafluoroethyl, 2,2,3,3- tetrafluoropropyl, 2,2,3,3, 3-pentafluoropropyl .
- a C 2 -C 6 alkenyl group refers to a linear or branched C 2 -C 6 alkenyl group.
- Examples of this group are: ethenyl, propenyl, butenyl .
- a C 2 -C 6 haloalkenyl group refers to a linear or branched C 2 -C alkenyl group, substituted by one or more halogen atoms, the same or different.
- Examples of this group are: 2, 2-dichloropropenyl, 1,2,2-trichloropropenyl.
- Examples of C 2 -C 6 alkynyl groups are: ethynyl, propargyl .
- a C 2 -C 6 haloalkynyl group refers to a C 2 -C 6 alkynyl group substituted by one or more halogen atoms, the same or different.
- C 2 -C 6 haloalkynyl group 3- chloropropynyl .
- a C 3 -C 6 cycloalkyl group refers to a cycloalkyl group whose ring consists of 3-6 carbon atoms, optionally substituted by one or more substituents, the same or different.
- Examples of this group are: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl.
- a C ⁇ C 6 alkoxy group refers to a C ⁇ -C 6 alkoxy group, wherein the aliphatic portion is a C ⁇ -C 6 alkyl group, as defined above.
- Examples of this group are: methoxy, ethoxy.
- a C ⁇ -C 6 haloalkoxy group refers to a C ⁇ -C 6 haloalkoxy group, wherein the aliphatic portion is a C ⁇ -C 6 haloalkyl group, as defined above.
- a C ⁇ -C 6 alkylthio group refers to a C ⁇ -C 3 alkylthio group, wherein the aliphatic portion is a C ⁇ -C 6 alkyl group, as defined above.
- Examples of this group are: methylthio, ethylthio .
- Ci-C ⁇ haloalkylthio group refers to a C ⁇ -C 6 haloalkylthio group wherein the aliphatic portion is a Ci-C ⁇ haloalkyl group, as defined above.
- Examples of this group are: trifluoromethylthio, 1, 1,2, 2-tetrafluoroethylthio.
- a C 3 -C 6 cycloalkoxy group refers to a C 3 -C 6 cycloalkoxy group wherein the aliphatic portion is a C 3 -C 6 cycloalkyl group, as defined above.
- Examples of this group are: cyclopentoxy, cyclohexyloxy.
- a C 2 -C 8 alkoxycarbonyl group refers to an alkoxycarbonyl group wherein the aliphatic portion is a Ci-C alkyl group, as defined above.
- Examples of this group are: methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl .
- a C 2 -C 8 alkylaminocarbonyl or C 3 -C ⁇ 5 dialkylaminocarbonyl group refers to an alkylaminocarbonyl or dialkylaminocarbonyl group wherein the aliphatic portion is one or two C ⁇ -C 7 alkyl groups respectively, as defined above. Examples of this group are: N- methylaminocarbonyl, N,N-dimethylaminocarbonyl, N- isopropylaminocarbonyl, N-ethyl-N-methylaminocarbo- nyl.
- a C 2 -C 8 alkylcarbonyl group refers to an alkylcarbonyl group wherein the aliphatic portion is a C 1 -C7 alkyl group, as defined above.
- aryl group refers to an aromatic carbocyclic group optionally substituted by one or more groups the same or different.
- Examples of this group are: phenyl, naphthyl.
- a heteroaryl group refers to an aromatic heterocyclic penta- or hexa-atomic group, also benzocondensed or heterobicyclic, containing from 1 to 4 hetero-atoms selected from nitrogen, oxygen, sulfur, optionally substituted by one or more groups, the same or different.
- heteroaryl groups are: pyridine, pyrimidine, pyridazine, pyrazine, triazine, tetrazine, quinoline, quinoxaline, quinazoline, furan, thiophene, pyrrole, oxazole, thiazole, isoxazole, isothiazole, oxadiazole, thiadiazole, pyrazole, imidazole, triazole, tetrazole, indole, benzofurane, benzothiophene, benzoxazole, benzothiazole, benzoxadiazole, benzothiadiazole, benzopyrazole, benzimidazole, benzotriazole, triazolopyridine, triazolopyrimidine, thiazolotriazo- le.
- a heterocyclic group refers to a saturated or unsaturated ring with from three to twelve units, • containing at least one hetero-atom selected from nitrogen, oxygen, sulfur, optionally condensed with another aromatic or non-aromatic ring.
- heterocyclic rings are: pyrrolidine, piperidine, dihydropiperidine, dihydropyridine, piperazine, morpholine, thiazine, indoline.
- the term optionally or possibly substituted refers to a group which can have one or more substituents, the same or different, preferably selected from the following groups: halogen atoms possibly selected from chlorine, fluorine, bromine, iodine; C ⁇ -C 6 alkyl, alkoxy, alkylthio, in turn optionally substituted by halogen atoms; alkoxycarbonyl or alkylaminocarbonyl optionally halogenated; aminocarbonyl; C 2 -C a dialkylaminocarbonyl optionally halogenated; C 2 -C 8 alkylcarbonyl; C 2 -C 8 alkylcarbonyloxy; cyano; nitro; formyl; hydroxy; amino; carboxy.
- the compounds having formula (I) have high fungicidal activity.
- a further object of the present invention relates to the processes for the preparation of the compounds having general formula (I) .
- the compounds having general formula (I) can be obtained by the condensation of a compound having general formula (II) with a thiazolyl derivative having general formula (III) , according to reaction scheme A: Scheme A
- L represents a leaving group such as a chlorine atom, a bromine atom, an RS0 3 ⁇ group wherein R represents a C ⁇ -C 6 alkyl or haloalkyl or a phenyl optionally substituted.
- the reaction can be conveniently carried out in an inert organic solvent, at a temperature ranging from 0°C to the boiling point of the reaction mixture, optionally in the presence of an inorganic or organic base.
- Preferred solvents for the reaction are: alcohols (methanol, ethanol, propanol, methoxyethanol etc.); ethers (ethyl ether, isopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane, etc.); esters (ethyl acetate, etc.); ketones (acetone, methylethylketone etc.); chlorinated hydrocarbons (methylene chloride, dichloroethane, chloroform, carbon tetrachloride, etc.); aromatic hydrocarbons
- Preferred inorganic bases are: hydrides, hydroxides, carbonates of alkaline or earth-alkaline metals (sodium, potassium, calcium, etc.).
- Preferred organic bases are: pyridine, dimethylaminopyridine, aliphatic amines, (diethyl- amine, triethylamine, etc.), cyclic amines (morpholine, piperidine, diazabicycloundecene, etc.); alcoholates of alkaline metals (potassium t-butylato, etc. ) .
- the compounds having general formula (I), wherein Z is N and Y is NH can be alternatively obtained by the reaction of the corresponding compound having formula (I) wherein Z is N and Y is 0 with a suitable a ine having the formula R 4 NH 2 wherein R 4 has the meanings defined above.
- the reaction can be conveniently carried out in an inert organic solvent, at a temperature ranging from 0°C to the boiling point of the reaction mixture .
- Preferred solvents for the reaction are: alcohols (methanol, ethanol, propanol, methoxyethanol, etc.); ethers (ethyl ether, isopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane, etc.); ketones (acetone methylethylketone etc.); chlorinated hydrocarbons (methylene chloride, dichloroethane, chloroform, carbon tetrachloride etc.); aromatic hydrocarbons (benzene, toluene, xylene, etc.); aliphatic hydrocarbons (hexane, heptane cyclohexane, etc.); dipolar aprotic solvents (N,N- dimethylformamide, dimethylsulfoxide, sulfolane, etc.); or mixtures
- isomers E of the compounds having formula (I) are preferred, and consequently the use of isomers E of the compounds having formula (I), is also preferred.
- the intermediates having general formula (II) are known compounds .
- the thiazoles having general formula (III) when not known as such, can be prepared by means of the methods known in literature, according to what is described, for example, in: Journal of Medicinal Chemistry 1991, vol.34, pages 2158-2165.
- the thiazoles having general formula (III) wherein Ri has the meaning of a linear or branched Cx-C ⁇ polyhaloalkyl group are new compounds .
- a further object of the present invention therefore relates to compounds having general formula (III') :
- Ri' represents a linear or branched C ⁇ -C 6 polyhaloalkyl group and R 2 ' has the same meaning as R 2 and their use as intermediates for the preparation of compounds useful both in the agrochemical and pharmaceutical field.
- a C ⁇ -C 6 polyhaloalkyl group refers to a linear or branched C ⁇ -C 6 alkyl group substituted by at least two halogen atoms, the same or different.
- the group Ri' is selected from trifluoromethyl, difluoromethyl, chlorodifluoro- methyl, 2, 2, 2-trifluoroethyl, 2, 2, 3, 3-tetrafluoropropyl, 2,2, 3,3, 3-pentafluoropropyl, 1,1,2,2,2- pentafluoroethyl, 1, 2, 2, 2-tetrafluoroethyl, 1,1,2,2- tetrafluoroethyl .
- the group R 2 ' is preferably selected from a hydrogen atom, a halogen atom, a linear or branched C ⁇ -C 6 alkyl or haloalkyl group, optionally substituted, a C 3 -C 6 cycloalkyl group, optionally substituted; an aryl group, optionally substituted; a heteroaryl group, optionally substituted; a cyano group; a linear or branched C 2 -C 8 alkoxycarbonyl group, optionally substituted.
- the compounds having formula (III' ) can also exist in a tautomeric ketonic form (IV), and also in mixtures between the two forms (III') e (IV) .
- a further object of the present invention relates to the processes for the preparation of the compounds having general formula (III').
- Ri' and R 2 ' have the meanings defined above
- X represents a leaving group such as a chlorine atom, a bromine atom, a RS0 ⁇ group
- W represents an OR group, wherein R has the meaning of a linear or branched C ⁇ -C 6 alkyl or haloalkyl or phenyl, optionally substituted; or a halogen atom; or an H2 group.
- the reaction can be conveniently carried out in an inert organic solvent, at a temperature ranging from -70°C to the boiling point of the reaction mixture, optionally in the presence of an inorganic or organic base.
- Preferred solvents for the reaction are: aromatic hydrocarbons (benzene, toluene, xylene, etc.); aliphatic hydrocarbons (hexane, heptane, cyclohexane, etc.); alcohols (methanol, ethanol, etc.); ethers (ethyl ether, isopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane, etc.); esters (ethyl acetate, etc.); ketones (acetone, methylethylketone, etc.); chlorinated hydrocarbons (methylene chloride, dichloroethane, chloroform, carbon tetrachloride, etc.); dipolar aprotic solvents (N,N-dimethylformamide, dimethylsulfoxide, sulfolane, etc. ) .
- Preferred inorganic bases are: hydrides, hydroxides, carbonates of alkaline and earth-alka
- Preferred organic bases are: pyridine, dimethylaminopyridine, aliphatic amines, (diethylamine, triethylamine, etc.), cyclic amines (morpholine, piperidine, diazabicycloundecene, etc.); alcoholates of alkaline metals (potassium t-butylate, etc. ) .
- the thioamides having general formula (V) when they are not known as such, can be prepared by means of the methods known in literature, according to what is described, for example, in : Houben-Weil Band E5 / Opera 1 (pages 1218-1277) .
- the intermediates having general formula (VI) are compounds known in literature, for example, in: Journal American Chemical Society (1944), vol.66, page 2074; Synthesis (1969), page 39.
- the compounds having general formula (III') can be obtained by condensation between a nitrile having formula (VII) and a carboxylic derivative having formula (VIII) according to reaction scheme C:
- T represents an OH group or an OR group wherein R has the meaning of a linear or branched d.-
- the reaction can be conveniently carried out in the presence of or in the absence of an inert organic solvent, at a temperature ranging from ⁇ 70°C to the boiling point of the reaction mixture, optionally in the presence of an inorganic or organic base or alternatively in the presence of an inorganic or organic acid.
- Preferred solvents for the reaction are: aromatic hydrocarbons (benzene, toluene, xylene, etc.); aliphatic hydrocarbons (hexane, heptane, cyclohexane, etc.); alcohols (methanol, ethanol, ecc.) ; ethers (ethyl ether, isopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane, etc.); esters (ethyl acetate, etc.); ketones (acetone, methylethylketone, etc.); chlorinated hydrocarbons (methylene chloride, dichloroethane, chloroform, carbon tetrachloride, etc.); dipolar aprotic solvents (N,N-dimethylformamide, dimethylsulfoxide, sulfolane, etc. ) .
- Preferred inorganic bases are: hydroxides, carbonates of alkaline or earth-al
- Preferred organic bases are: pyridine, dimethylaminopyridine, aliphatic amines, (diethyl- amine, triethylamine, etc.), cyclic amines
- Preferred inorganic acids are: hydrochloric acid, sulfuric acid, etc.
- Preferred organic acids are: acetic acid, citric acid, etc.
- the nitriles having general formula (VII) and the carboxylic derivatives having general formula (VIII) when they are not known as such, can be prepared by means of the methods known in literature, for example, according to what is described in Journal American Chemical Society (1943), vol.65, page 1459.
- the compounds having general formula (I) have a particularly high fungicidal activity against phytopathogenic fungi which attack vines, sugar beet, cereals, vegetables, rice, Cucurbitaceae, fruit trees.
- phytopathogenic fungi which can be effectively fought with the compounds having general formula (I) are:
- the compounds having general formula (I) are capable of exerting a fungicidal action of both a curative and preventive nature and have a low or non- existing phytotoxicity.
- An object of the present invention therefore also relates to the use of the compounds having general formula (I) as insecticides and/or acaricides.
- a further object of the present invention consequently relates to a method for the control of phytopathogenic fungi in agricultural crops by the application of the compounds having general formula
- the quantity of compound to be applied to obtain the desired effect can vary in relation to various factors such as, for example, the compound used, the crop to be preserved, the type of pathogen, the degree of infection, the climatic conditions, the method of application, the formulation adopted.
- compositions or compounds having formula (I) can be effected on any part of the plant, for example on the leaves, stems, branches and roots, or on the seeds themselves before sowing, or on the ground in which the plant grows .
- compositions can be used in the form of dry powders, wettable powders, emulsifiable concentrates, micro-emulsions, pastes, granulates, solutions, suspensions, etc.: the choice of the type of composition will depend on the specific use.
- compositions are prepared in the known way, for example by diluting or dissolving the active substance with a solvent medium and/or a solid diluent, optionally in the presence of surface-active agents .
- Solid diluents, or carriers which can be used are, for example: silica, kaolin, bentonite, talc, fossil flour, dolomite, calcium carbonate, magnesia, chalk, clays, synthetic silicates, attapulgite, seppiolite.
- Liquid diluents which can be used are, for example, in addition to water, aromatic organic solvents (xylols or alkyl benzene mixtures, chlorobenzene, etc.), paraffins (oil fractions), alcohols (methanol, propanol, butanol, octanol, glycerine, etc.), esters (ethyl acetate, isobutyl acetate etc.), ketones (cyclohexanone, acetone, acetophenone, isophorone, ethylamylketone, etc.), amides (N,N-dimethylformamide, N-methylpyrrolidone, etc. ) .
- aromatic organic solvents xylols or alkyl benzene mixtures, chlorobenzene, etc.
- paraffins oil fractions
- alcohols methanol, propanol, butanol, octanol, gly
- compositions can also contain special additives for particular purposes, for example adhesion agents such as arabic rubber, polyvinyl alcohol , polyvinylpyrrolidone, etc..
- compositions compatible with the compounds having general formula (I), such as for example other fungicides, phytoregulators, antibiotics, herbicides, insecticides, fertilizers.
- fungicides which can be included in the compositions of the invention are: AC-382042, acibenzolar, ampropylphos, anilazine, azaconazole, azoxystrobin, benalaxyl (in its racemic form or as an optically active R isomer) , benclothiaz, beno yl, bitertanol, blasticidin-S, bromuconazole, bupirimate, buthiobate, captafol, captan, carbendazim, carboxin, carpropamid, chinomethionat, chloroneb, chlorothalonil, chlozolinate, cyazofamid, cymoxanil, cyproconazole, cyprodinil, debacarb, dichlofluanid, dichlone, dichlobutrazol, dichlomezine, dichloran, dicyclomet, diethofencarb, diphen
- fungicidal compounds are commercial compounds or compounds about to be commercialized. Their description can be easily found in technical literature, for example in "The pesticide manual", 2000, XII edition, British Crop Protection Council Ed.
- Dipeptide with a fungicidal activity refers to one of the compounds among those claimed in patent application EP-A-1028125.
- concentration of active principle in the above compositions can vary within a wide range depending on the active compound, the applications for which they are destined, the environmental conditions and type of formulation adopted.
- the concentration of active principle generally ranges from 1% to 90%, preferably from 5 to 50%.
- reaction mixture is diluted with water (200 ml) and extracted with ethyl acetate (100 ml x 2 times) .
- the mixture is diluted with water (20 ml) and extracted with ethyl acetate (20 ml x 2 times) .
- the organic phases are joined, anhydrified with sodium sulfate and concentrated at reduced pressure.
- the raw product obtained is purifed by chromatography on silica gel eluating with hexane/ethyl acetate 9/1. 1.3 g of the desired product are obtained.
- the mixture is diluted with water (20 ml) and extracted with ethyl acetate (20 ml x 2 times) .
- the organic phases are joined, anhydrified with sodium sulfate and concentrated at reduced pressure.
- the raw product obtained is purified by chromatography on silica gel eluating with hexane/ethyl acetate 9/1. 2.9 g of the desired product are obtained.
- reaction mixture is kept under stirring at -10°C for about 20' , and a solution of methyl 2-bromopropionate (27.6 ml) in N,N-dimehylformamide (60 ml) is then added dropwise.
- reaction mixture After 45' at a temperature ranging from -10°C to -5°C, the reaction mixture is diluted with acid water (200 ml) , bringing the pH to about 6, and extracted with ethyl acetate (100 ml x 2 times) .
- the organic phases are joined, anhydrified with sodium sulfate and concentrated at reduced pressure.
- the raw product obtained is purified by chromatography on silica gel eluating with hexane/ethyl acetate 99/1.
- Leaves of vines (cultivar Dolcetto) , cultivated in vases in a conditioned environment (20 ⁇ 1°C, 70% relative humidity) are treated by spraying both sides of the leaves with compounds 1, 2 and 3, dispersed in a hydroacetone solution at 20% by volume of acetone.
- the plants After remaining 24 hours in a conditioned environment, the plants are sprayed on both sides of the leaves with an aqueous suspension of conidia of Plasmopara viticola (20000 conidia per cm 3 ) .
- the plants are kept in a humidity saturated environment at 21°C for the incubation period of the fungus .
- the fungicidal activity is evaluated according to a percentage evaluation scale from 0 (completely infected plant) to 100 (healthy plant) . All the compounds tested showed a fungus control of over 90 at a concentration of 1000 ppm. EXAMPLE 9.
- the plants After remaining 24 hours in a conditioned environment, the plants are sprayed on both sides of the leaves with an aqueous suspension of conidia of Erysiphe graminis (200000 conidia per cm 3 ) .
- the plants are kept in a humidity saturated environment at a temperature ranging from 18 to 24°C for the incubation period of the fungus.
- the fungicidal activity is evaluated according to a percentage evaluation scale from 0 (completely infected plant) to 100 (healthy plant) .
- Leaves of wheat plants (cultivar Gemini) , cultivated in vases in a conditioned environment (20 ⁇ 1°C, 70% relative humidity) are treated by spraying both sides of the leaves with compounds 1, 2 and 3, dispersed in a hydroacetone solution at 20% by volume of acetone.
- the plants After remaining 24 hours in a conditioned environment, the plants are sprayed on both sides of the leaves with an aqueous suspension of conidia of Puccinia recondita (200000 conidia per cm 3 ) .
- the plants are kept in a humidity saturated environment at a temperature ranging from 18 to 24°C for the incubation period of the fungus.
- the fungicidal activity is evaluated according to a percentage evaluation scale from 0 (completely infected plant) to 100 (healthy plant) . All the compounds tested showed a fungus control of over 90 at a concentration of 1000 ppm.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI20012640 ITMI20012640A1 (en) | 2001-12-13 | 2001-12-13 | NEW TAZOLIC DERIVATIVES WITH FUNGICIDE ACTIVITY |
ITMI20010264 | 2001-12-13 | ||
IT2002MI000753A ITMI20020753A1 (en) | 2002-04-09 | 2002-04-09 | NEW FUNGICIDE AND INTERMEDIATE THIAZOLIC DERIVATIVES FOR THEIR PREPARATION |
ITMI20020075 | 2002-04-09 | ||
PCT/EP2002/014070 WO2003050096A1 (en) | 2001-12-13 | 2002-12-11 | Thiazole derivatives with fungicidal activity |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1453817A1 true EP1453817A1 (en) | 2004-09-08 |
EP1453817B1 EP1453817B1 (en) | 2006-04-26 |
Family
ID=26332793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02795153A Expired - Lifetime EP1453817B1 (en) | 2001-12-13 | 2002-12-11 | Thiazole derivatives with fungicidal activity |
Country Status (9)
Country | Link |
---|---|
US (1) | US7166620B2 (en) |
EP (1) | EP1453817B1 (en) |
JP (1) | JP2005511739A (en) |
AT (1) | ATE324370T1 (en) |
AU (1) | AU2002361049A1 (en) |
BR (1) | BR0214651A (en) |
DE (1) | DE60211018T2 (en) |
ES (1) | ES2263845T3 (en) |
WO (1) | WO2003050096A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070098900A1 (en) * | 2004-11-05 | 2007-05-03 | Fuji Hunt Photographic Chemicals, Inc. | Media providing non-contacting formation of high contrast marks and method of using same, composition for forming a laser-markable coating, a laser-markable material and process of forming a marking |
BR112016000386B1 (en) * | 2013-07-12 | 2020-04-07 | Sumitomo Chemical Co | tetrazolinone compounds, their use, pyridine compounds, plague control agent and method |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9122098D0 (en) | 1991-10-17 | 1991-11-27 | Ici Plc | Fungicides |
DE4305502A1 (en) * | 1993-02-23 | 1994-08-25 | Basf Ag | Ortho-substituted 2-methoxyiminophenylacetic acid methylamides |
WO1999040076A1 (en) * | 1998-02-05 | 1999-08-12 | Nippon Soda Co., Ltd. | Thiazole compounds, production process, pest control agent, and antifungal agent |
-
2002
- 2002-12-11 WO PCT/EP2002/014070 patent/WO2003050096A1/en active IP Right Grant
- 2002-12-11 DE DE60211018T patent/DE60211018T2/en not_active Expired - Lifetime
- 2002-12-11 BR BR0214651-7A patent/BR0214651A/en not_active IP Right Cessation
- 2002-12-11 EP EP02795153A patent/EP1453817B1/en not_active Expired - Lifetime
- 2002-12-11 ES ES02795153T patent/ES2263845T3/en not_active Expired - Lifetime
- 2002-12-11 JP JP2003551121A patent/JP2005511739A/en active Pending
- 2002-12-11 US US10/497,611 patent/US7166620B2/en not_active Expired - Fee Related
- 2002-12-11 AT AT02795153T patent/ATE324370T1/en not_active IP Right Cessation
- 2002-12-11 AU AU2002361049A patent/AU2002361049A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO03050096A1 * |
Also Published As
Publication number | Publication date |
---|---|
DE60211018T2 (en) | 2006-12-21 |
JP2005511739A (en) | 2005-04-28 |
WO2003050096A1 (en) | 2003-06-19 |
BR0214651A (en) | 2004-09-14 |
DE60211018D1 (en) | 2006-06-01 |
EP1453817B1 (en) | 2006-04-26 |
ATE324370T1 (en) | 2006-05-15 |
ES2263845T3 (en) | 2006-12-16 |
AU2002361049A1 (en) | 2003-06-23 |
US20050065197A1 (en) | 2005-03-24 |
US7166620B2 (en) | 2007-01-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10149473B2 (en) | Aminoindanes amides having a high fungicidal activity and their phytosanitary compositions | |
AU2011347585A1 (en) | Aminoindanes amides having a high fungicidal activity and their phytosanitary compositions | |
US7332518B2 (en) | Carboxamides as fungicides in agriculture | |
WO2010109301A1 (en) | Benzamidic compounds having fungicidal activity and relative use | |
ITMI20101564A1 (en) | PHENYLAMIDINE WITH HIGH FUNGICIDAL ACTIVITY AND RELATED USE | |
US5668160A (en) | Fungicidal oxazolyl and oxadiazolyl derivatives | |
WO2015121802A1 (en) | Benzoylphenyl-formamidines having a fungicidal activity, their agronomic compositions and relative use | |
EP2231637B1 (en) | Pyridazine fungicides | |
WO1998021174A1 (en) | Strobilurine analogue compounds with fungicidal activity | |
EP1453817A1 (en) | Thiazole derivatives with fungicidal activity | |
US6124356A (en) | Fungicides | |
JP2007502314A (en) | Copper salts of organic acids and their use as fungicides | |
ITMI20012640A1 (en) | NEW TAZOLIC DERIVATIVES WITH FUNGICIDE ACTIVITY | |
WO1997038997A1 (en) | Substituted oxazolidinediones and their use as fungicides | |
IT202000007234A1 (en) | Compounds with fungicidal activity, relative agronomic compositions and use for the control of phytopathogenic fungi | |
ITMI20101575A1 (en) | PHENYLAMIDINE WITH HIGH FUNGICIDAL ACTIVITY AND RELATED USE | |
WO1997038995A1 (en) | Fungicidal oxazolidinedione derivatives | |
EP0909760A1 (en) | New analogs of strobilurine having fungicidal properties, and their application for controlling phytopathogenous fungi |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20040524 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO |
|
17Q | First examination report despatched |
Effective date: 20041203 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: ISAGRO RICERCA S.R.L. |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
REF | Corresponds to: |
Ref document number: 60211018 Country of ref document: DE Date of ref document: 20060601 Kind code of ref document: P |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060726 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060726 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: AMMANN PATENTANWAELTE AG BERN |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060926 |
|
NLV1 | Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act | ||
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20061211 |
|
ET | Fr: translation filed | ||
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2263845 Country of ref document: ES Kind code of ref document: T3 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20061231 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20070129 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060727 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060726 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20061211 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20060426 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20091215 Year of fee payment: 8 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: ES Payment date: 20100113 Year of fee payment: 8 Ref country code: FR Payment date: 20091221 Year of fee payment: 8 Ref country code: GB Payment date: 20091209 Year of fee payment: 8 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20091203 Year of fee payment: 8 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20091211 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20091222 Year of fee payment: 8 |
|
PGRI | Patent reinstated in contracting state [announced from national office to epo] |
Ref country code: IT Effective date: 20110616 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20101211 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20110831 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20101231 Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110103 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20101231 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 60211018 Country of ref document: DE Effective date: 20110701 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110701 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20101211 |
|
PGRI | Patent reinstated in contracting state [announced from national office to epo] |
Ref country code: IT Effective date: 20110616 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20120220 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20101212 |