Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
  • A61B5/316—Modalities, i.e. specific diagnostic methods
  • A61B5/369—Electroencephalography [EEG]
  • A61B5/375—Electroencephalography [EEG] using biofeedback
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
  • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
  • A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
  • A61B5/25—Bioelectric electrodes therefor
  • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
  • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
  • A61B5/7235—Details of waveform analysis
  • A61B5/7253—Details of waveform analysis characterised by using transforms
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N1/00—Electrotherapy; Circuits therefor
  • A61N1/18—Applying electric currents by contact electrodes
  • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
  • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
  • A61B5/4035—Evaluating the autonomic nervous system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
  • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
  • A61B5/4041—Evaluating nerves condition
  • A61B5/4047—Evaluating nerves condition afferent nerves, i.e. nerves that relay impulses to the central nervous system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N1/00—Electrotherapy; Circuits therefor
  • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Definitions

• the brain is one of the last great f ontiers in the bio-medical sciences.
• the unraveling of its mysterious complexities as related to medical diagnosis and treatment is a quest as great as inventing technology and gathering resources to travel to the moon.
• Brain signals direct
• the brain senses, computes and decides before it sends electrical and chemical instructions to the
• the brain is a beautiful information processor that not only controls the body it lives in, but communicates with other brains residing in other bodies. Such interrelation to another brain can alter the electrochemical function in both brains.
• This fountain of knowledge now makes it possible to open up a new technology for electrical modulation of organ function.
• Such knowledge opens new electrical treatment modalities for life threatening emergencies and cardiac, respiratory and digestive conditions, unaccessible before.
• This new technology makes it possible to detect the electrical waveforms being generated by the brain and to ascertain what the signal is for.
• This invention provides a way to evolve the known and unknown waveforms into electronic devices which can broadcast such signals onto selected nervous system components as medical treatments.
• the brain controls, via the autonomic nervous network, the vegetative functions of the major organs. These organs represent the minimal requirement to support life. These are the organs that must function even if the brain is in coma, and the owner unable to think or do anything, if life is to continue. Major organ function must always be maintained at a certain minimal level for maintaining organism life, otherwise death is certain. Such control is done via a nervo.us system that consists of two main divisions: a) the central nervous system (brain)
• the peripheral system consisting of cranial and spinal nerves plus ganglia.
• the autonomic nervous system (ANS) which carries all efferent impulses except for the motor innervation of skeletal muscles.
• the ANS is mainly outside voluntary control and regulates the heart beat and smooth muscle contraction of many organs including digestive and respiratory. Also, the ANS controls exocrine and some endocrine organs along with certain metabolic activity. In addition, there is activity from parasympathetic and sympathetic innervation which oppose each other to attain a balance of tissue and organ function.
• the nervous system is constructed of nerve cells called neurons which have supporting cells called glia. Neurons are electrically excitable and provide a method whereby instructions are carried from the brain to modulate critical
• the neuron has a protrusion called an axon that can be as short as a few millimeters or longer than a meter.
• the axon provides and uses nerve fibers to carry electrical signals that end at a synapse.
• a synapse is at the end of an axon. It faces another synapse from a neighboring axon across a gap. To cross such a gap the electrical signal from the brain must
• Neurons have a body (or soma) and are the morphological and functioning unit that sends signals along their axons until such signals instruct the organ it reaches.
• Operative neuron units that carry signals from the brain are classified as "efferent” nerves.
• "Afferent" nerves are those that carry sensor or status information to the brain.
• the brain computes and generates those electrical signals that are required as a result of the incoming data (afferent signals) it has collected.
• afferent signals received by the brain provide sophisticated organ and overall body operational status. Such information spans the entire body from within and also environmental status detected from areas immediately outside of the body proper and at some distance.
• Outside data reaching the brain may relate to temperature change or a dangerous situation like approaching strangers or even potential mating possibilities.
• Such outside afferent sensory data is provided by eyes, ears, nose, tongue and skin.
• proprioception providing sensation in the musculoskeletal system, i.e., deep sensations.
• Other afferent-type nerve sensors called nociceptors detect noxious stimuli and pain. Nociceptors alert the brain to tiny things that are deemed undesirable and require some immediate action within the brain. This range of information arriving at the brain is processed for action.
• the efferent nerves provide quick adjustment on performance for the various organ systems or even instruct the skeletal-motor neurons to run, walk, hide, help or physically approach for more sensory information.
• the invention describes specific waveforms and a method to precisely acquire the key operative electrical waveforms from selected axons, nerveplexus or ganglion connections of the autonomic nervous system.
• Such waveform data is stored and categorized as to the actual purpose of such signals. This is much like the ongoing effort to identify and categorize human genes.
• the invention provides a method for modulating body organ functioning. According to the method, waveforms that are generated and carried in a body are collected from the body. Such collected waveforms are then electrically stored. Then, one or more of the collected waveforms can be transmitted to a body organ to stimulate or regulate organ function.
• the collected waveforms are transformed into a readable format for a processor.
• the transformation of the collected coded waveforms into a readable format includes transforming analog signals into a digital form.
• the collected waveforms are stored and cataloged according to the function performed by the waveforms in the body.
• a digital to analog converter is used to convert the cataloged waveforms to an analog form, and the converted waveforms are then applied to a body organ to regulate for medical treatment purposes.
• the invention further provides an apparatus for modulating body organ functioning.
• the apparatus includes a source of collected waveforms that are indicative of body organ functioning, means for transmitting collected waveforms to a body organ, and means for applying the transmitted waveforms to the body organ to stimulate or adjust organ function.
• the transmitting means may include a digital to analog converter.
• collected waveforms comprises a computer which has the collected waveforms stored in digital format.
• the computer includes separate storage areas for collected waveforms of different categories.
• the apparatus further includes means for collecting waveforms from a body and cataloging and transmitting such collected waveforms to the source.
• the collecting means may be comprised of a sensor placed on the body.
• a recorder is provided to record the sensed waveforms in analog form.
• An analog to digital converter is connected to the recorder for
• the apparatus includes a digital to analog converter for converting the collected waveforms for retransmission to a body for medical treatment purposes.
• FIG. 1 is a schematic diagram of one form of apparatus for practicing the method according to the invention
• FIG 2 is a flow chart of the software program when the waveform enters the computer
• FIG. 3 is a flow chart of the software program when the operator retrieves and broadcasts the waveform from within the computer;
• FIGS. 4 A - 4H are schematics of representative waveforms, embodied in the invention, carried by neurons after generation in the medulla oblongata or from sensory neurons going to the medulla oblongata; and
• FIGS. 5 A - 5H are schematics of alternative waveforms, as described in the invention, that affect the nervous system.
• the vagus nerve is a wandering nerve (Vagus means wandering) that winds throughout the body after it emerges from the medulla oblongata located in the hind brain.
• the hypoglossal and accessory nerves also emerge from the medulla oblongata and are interlaced with the vagus to harmoniously accomplish basic life support.
• the signals travel on the surface of the vagus nerve but below its insulating myelin sheath.
• the electrical output of selected afferent and efferent nerves can be made accessible
• Afferent and efferent nerves travel in the same nerve bundles or can be routed separately.
• To gain direct measurement of the electrical waveforms it may initially require shaving away the insulating fasciculus and myelin sheath. Seismic, ultrasonic, receiving antennas, direct conduction and other methods may be used to capture the coded brain signals as they relate to body organ performance. Such signals are then stored and replicated for electrical return to the appropriate place for medical treatment concerned with modulating organ function.
• the invention comprises a method for recording, storing, and broadcasting specific brain waveforms to modulate human and animal body organ functioning.
• One form of the method for recording, storing, and broadcasting brain waveforms is comprised of at least one sensor in the form of an electrode or pair of electrodes 10, an analog recorder 12, an analog to digital converter 14, a computer 16, and a digital to analog converter 18.
• the electrode 10 is attached to a nerve 20 in the human or animal body, and receives the coded electric waveform from the nerve 20.
• the electrode 10 may be comprised of silver wire, tungsten wire, or any wire suitable for conduction of the pe ceptible electrical signals transported by the nerve 20.
• the electric waveform is recorded by an analog recorder 12 because the nerve 20 only transmits electric signals in analog form. Once the waveforms are recorded they are sent from the analog recorder 12 to the analog to digital converter 14.
• the converter 14 in a conventional fashion, transforms the waveforms from the analog format into a digital format, which is more suitable for computer processing.
• the converter 14 then transmits the converted waveforms to a computer 16 where the waveform is processed, stored, adjusted, and/or broadcast, as desired.
• Selected signals that have been digitized may be transferred to an application specific
• the processor or a linear analog device to be utilized to prepare and broadcast signals recognized by the brain or a selected organ as a modulating treatment.
• the waveform is transmitted from the computer 16 through a digital to analog converter 18.
• the waveform is converted back into analog form because the body only transmits
• the computer 16 contains software which is capable of identifying the function associated with particular waveforms. Many types of software can be developed by those skilled in the art to perform the functions of the invention, and particular software is not part of the present invention. As shown in the flow chart in Fig. 2, after beginning at step 22, at step 24 the computer 16 receives a digital waveform from the analog to digital converter 14. After the waveform is received, the software reads the waveform and at step 26 identifies the function of the particular waveform. Once the software identifies the function associated with the particular waveform, at step 28 the waveform or coded signal is directed to a particularized storage area. For example, if the waveform is used for digestive functions it may be stored in a separate area from waveforms used for respiratory functions.
• step 34 the software adjusts the waveform as required, in step 34. However, if it is decided that the waveform does not need to be adjusted, step 34 is bypassed and step 36 is performed whereby the waveform signal is broadcast to the specified body organ, after conversion to analog form.
• the brain often makes modifications to the waveforms in order to fine tune the function the brain requires or needs a particular organ to perform, and such is also performed by the present invention.
• Fig. 4 Representative waveforms that neurons carry after generation in the medulla oblongata are shown in Fig. 4. Such waveforms have a central linear carrier which is analog. The signal is of a direct current nature and has many coded modulations that provide directions or instructions to the receptor organ or system receiving it. Other representative waveforms for signals that can affect the nervous system are shown in Fig. 5. The waveforms can provide instructions as they leave the vagus or other nerve and arrive at organs of the body. Such signals are similar to the modulating instructions broadcast from the medulla oblongata.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Biomedical Technology (AREA)
• Pathology (AREA)
• Biophysics (AREA)
• Heart & Thoracic Surgery (AREA)
• Medical Informatics (AREA)
• Molecular Biology (AREA)
• Surgery (AREA)
• Physics & Mathematics (AREA)
• Hematology (AREA)
• Immunology (AREA)
• Vascular Medicine (AREA)
• Psychiatry (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Radiology & Medical Imaging (AREA)
• Psychology (AREA)
• Artificial Intelligence (AREA)
• Computer Vision & Pattern Recognition (AREA)
• Physiology (AREA)
• Signal Processing (AREA)
• Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
• Electrotherapy Devices (AREA)

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• 2002
  • 2002-11-18 CN CNB028273281A patent/CN1319489C/zh not_active Expired - Fee Related
  • 2002-11-18 JP JP2004504072A patent/JP2005519716A/ja active Pending
  • 2002-11-18 KR KR10-2004-7007748A patent/KR20040068924A/ko not_active Application Discontinuation
  • 2002-11-18 WO PCT/US2002/036879 patent/WO2003096145A2/en active IP Right Grant
  • 2002-11-18 AU AU2002367920A patent/AU2002367920B8/en not_active Ceased
  • 2002-11-18 IL IL16208902A patent/IL162089A0/xx unknown
  • 2002-11-18 CA CA002466445A patent/CA2466445A1/en not_active Abandoned
  • 2002-11-18 EP EP02807422A patent/EP1453417A4/en not_active Withdrawn
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• 2004
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• 2005
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