EP1438558A1 - Appareil d'echantillonnage et d'analyse d'echantillons - Google Patents

Appareil d'echantillonnage et d'analyse d'echantillons

Info

Publication number
EP1438558A1
EP1438558A1 EP01996075A EP01996075A EP1438558A1 EP 1438558 A1 EP1438558 A1 EP 1438558A1 EP 01996075 A EP01996075 A EP 01996075A EP 01996075 A EP01996075 A EP 01996075A EP 1438558 A1 EP1438558 A1 EP 1438558A1
Authority
EP
European Patent Office
Prior art keywords
shaft
closure
cassette
container
interior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01996075A
Other languages
German (de)
English (en)
Other versions
EP1438558A4 (fr
Inventor
Kenneth A. Alley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US2001/045749 external-priority patent/WO2003087776A1/fr
Publication of EP1438558A1 publication Critical patent/EP1438558A1/fr
Publication of EP1438558A4 publication Critical patent/EP1438558A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0003—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person
    • A61B2010/0006—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person involving a colour change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0009—Testing for drug or alcohol abuse
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above

Definitions

  • the present invention relates generally to a specimen testing apparatus and, more specifically, to a self-contained, tamper-proof system for screening
  • specimen is taken and tested by a local lab. If the test turns up positive, the specimen must then be sent to a more sophisticated, usually remotely located,
  • test strips turn a specific color in the presence of particular drug residues.
  • Each pregnancy test kits comprise a test strip designed to turn a specific color or to form a symbol (e.g. a "+" sign) in the presence of a hormone.
  • the hormone appears in a woman's urine only when she is pregnant.
  • Drug Free Enterprises, Inc. of Scott Valley, California, produces a self-contained urinalysis screening device that it markets under the name DRUGCHECK and claims to be able to detect a number of drug metabolites in minutes.
  • Phamatech, Inc. of San Diego, California markets a self-contained pregnancy test kit under the name CLEARCHOICE.
  • the present invention is a self-contained, tamper-proof
  • the present invention consists of a container,
  • a liquid specimen is stored in the container.
  • a series of windows or inlets permit the operator of the testing apparatus to activate the test by
  • This invention is designed for
  • the test may be conducted without having to physically access the specimen.
  • This feature has two important advantages; first, the nurse or other personnel supervising the test is not exposed to the specimen; second, it limits a person's ability to tamper with the specimen, especially if the closure is equipped with a tamper-proof tape.
  • the cassette is designed to allow the sample specimen to be shut off or isolated from the test area after the results are read, thereby preserving the remainder of the specimen.
  • the container can be
  • the closure has a substantially tubular portion that extends into the center of the container. This tubular
  • the tubular portion is sized to accept a pipe section of the cassette.
  • portion may be initially closed-off by a cap thereby forming a second, inner container within the first or original specimen container.
  • Figure 1 is a perspective view of a self-contained, tamper-proof screening apparatus in accordance with the present invention
  • Figure 2 is a cross-sectional view of the closure of the screening apparatus shown in Figure 1 taken along line 2-2;
  • Figure 3 is a longitudinal cross-sectional view of the cassette assembly shown in Figure 1 ;
  • Figure 4 is a cross-sectional view of the cassette or closure having a modified absorbent insert in accordance with the present invention
  • Figure 5 is an enlarged perspective view of a collar used to align the test strip and to apply a controlled amount of pressure on the test strip;
  • Figure 6A is an enlarged top view of a plug that may be used to
  • desired event i.e., unlocking the plug when a cassette is inserted
  • Figure 6B is a perspective view of the plug shown in Figure 6A;
  • Figure 7 is a top view of the cassette cover illustrated in Figure 3;
  • Figure 8A is an enlarged top view of closure
  • FIG. 8B is a detailed view of cover plug adapter to closure shaft
  • Figure 9 is a top view of another embodiment of a cassette having a
  • Figure 10 is a cross-sectional view of the cassette of Figure 9
  • Figure 11 is a special test strip with a tapered lower portion
  • Fig.12A is a top view of the testing and sampling apparatus
  • Fig.12B is another embodiment of the sampling and testing
  • Figure 13 is another embodiment of the testing apparatus disclosing a second, separate inner container, that isolates a portion of the specimen from the specimen in the outer container.
  • apparatus 10 comprises an outer container 12, a closure 14, and a test
  • the container 12 has a closed end 13 and an open end 15:
  • the container 12 is designed to hold liquid specimen (e.g., urine, blood,
  • the container 12 may be one of a
  • the closure 14 is adapted to securely attach to the container 12
  • closure 14 may be snapped on, screwed on, frictionally engaged or
  • tamper-proof tape,18, or other tamper prevention mechanism may be
  • closure has been removed or separated from the container.
  • the container 12 and closure 14 are illustrated. In a preferred embodiment, the container 12 and closure 14
  • methods for securing the closure to the container may be used (e.g., a snap top closure similar to prescription bottles, rubber O-ring with a mating
  • the container 12 need not have a cylindrical shape. If the container
  • a snap top or adhesive may be
  • the threads 18b of the closure 14 are located on a head section 24
  • the head section 24 is
  • the container 12 has a cylindrical shape; accordingly the
  • head section 24 of the closure 14 will have a circular shape to close and
  • the container 12 need not have a cylinder shape. If the container
  • a snap top or adhesive may be
  • the container 12 must be large enough to hold enough liquid
  • test cassette 16 is designated to be inserted into and removed
  • the test cassette holds one or more test strips 20 that
  • the closure 14 includes a lower shaft 26
  • the shaft 26 is tubular and defines and interior chamber
  • the shaft 26 has a closed distal end 25 and an inlet 22 near said distal
  • the shaft 26 should be long enough so that the distal end 25 (i.e.,
  • the shaft 26 has a circular cross-section. It
  • the shaft 26 may have a rectangular (including square), oval or other cross-
  • closure and cassette may be increased in order to minimize their linear length. This allows the closure and cassette to be used with any manufacturer's container.
  • An inlet 22 is positioned near the bottom end of the shaft 26, as
  • the inlet 22 defines a passageway from the
  • the inlet 22 allows a sample of the specimen to enter through the wall of the shaft 26 into the
  • the cassette 16 comprises a cover
  • the pipe section 38 has a valve opening 37.
  • pipe section 38 must be slightly less than the diameter of the interior
  • the pipe section 38 is
  • pipe section are designed to align with depressions in the shaft for locking
  • valve opening 37 of the cassette opens into inner cavity 39 of
  • the interior cavity 39 allows the valve opening 37 to
  • test strip 20 (preferably a rapid test strip) is positioned proximate
  • cover 34 is clear (or at least the portion of the cover that overlies the test
  • cover 34 may also be designed with a
  • magnifying window 84 that enlarges the appearance of any markings or
  • the cover may contain indicia 85 to identify the
  • test strip or the metabolites or compounds the test strip will screen.
  • Other indicia on the cover may identify the patient, indicate the series of the particular test, identify the lab and its location or provide other instructional or even marketing information.
  • the cover 34 may also identify the patient, indicate the series of the particular test, identify the lab and its location or provide other instructional or even marketing information.
  • the cover 34 may also identify the patient, indicate the series of the particular test, identify the lab and its location or provide other instructional or even marketing information.
  • the cassette is designed to rotate with
  • the cassette rotates when a technician turns the cassette cover 34.
  • the cover 34 may include a pair of gripping ears 137 which
  • the cassette cover 34 may be sealed onto the cassette 16 during
  • the cover 34 will prevent any leakage or contamination of the specimen once the test is activated.
  • the cover also protects the test
  • FIG. 3 only illustrates an apparatus 10 utilizing a single
  • test strip multiple strips may be included. Further, each test strip 20 may be included. Further, each test strip 20 may be included. Further, each test strip 20 may be included.
  • test strip may be designed to test for one drug, a plurality of drugs and/or biological organisms or any application where a test strip may be applied (i.e., micro
  • the subject invention may be used independent of a test strip (e.g., to store and transport a specimen).
  • test strip 20 is bent or flexed
  • test strip is in a
  • test strip 20 extends into the inner
  • test strip 20 a lateral flow colloidal gold test strip. Also, by flexing the test strip 20 the
  • lateral flow is enhanced by microscopically stretching (i.e., elongating) the
  • test strip membrane in the lateral direction of the flow of any specimen at the point of flexing.
  • the flexing of the test strip is just
  • a collar 52 having a living hinge 56 may
  • the collar 52 acts as a barrier that prevents contamination of the area
  • test strip 20 is exposed to a controlled or desired quantity
  • the living hinge 56 of the collar is designed to apply controlled
  • test strip 20 In prior art test cassettes, the test strip lays
  • test strip i.e., the test strip is made from many layers of material and many different chemicals which tend to separate if not for the exterior pressure).
  • the collar 52 replaces the need for protruding
  • test strip material preferably without the chemically
  • reactive portion may extend vertically to the bottom of the inner cavity 39,
  • test strip overlap an absorbent wick 78.
  • embodiment illustrates a specially designed absorbent pad 79 that
  • absorbent pad 79 grips the test strip for the purpose of positioning the test
  • test strip provides the needed pressure that improves the performance of the chemical portion of the test strip, and wicks the specimen up to the test strip 20.
  • This absorbent pad 79 also helps position the test strip during
  • the absorbent pad 79 includes at the upper end a collar 77
  • test strip designed to provide a more controlled wetting of the test strip.
  • test strip membrane region onto the test strip membrane region. It may be desired to have a testing apparatus that is not in the upright position or in the case the specimen has
  • the absorbent pad will control the amount of sample onto the test
  • strip It may also be used as a filter or buffer (adding a reagent) to work in
  • the absorbent pad 79 may be chemically treated
  • treatment of the absorbent pad may provide a reagent mix to the sample at
  • test strip may have an extended
  • the cassette's inner cavity 39 may be
  • the portion of the test strip that lays against top section 36 may
  • the absorption pad assists in the wicking process and may also absorb any excess specimen that may have been wicked up to the chemically reactive portion of the test strip.
  • Rails 120 be incorporated in the top section 36 of the cassette to
  • a gully 92 may be
  • rails 120 also help to prevent the lid 34 from compressing the test strip by
  • Cassette 16 may be snapped into closure 14 at the
  • the cassette 16 is uniquely configured to have lips 61 that provide a snap fit.
  • test strip is pre-positioned in the cassette and
  • the cover 34 is secured to the top section 36 of the cassette.
  • valve opening 37 is not aligned with inlet 22.
  • Closure 14 is
  • inlet 22 is
  • the container 12 is totally self-contained and there is no reason for a technician in the local lab
  • the container may be shipped to a first party.
  • the drug test or drug screening in this example is activated by
  • ears 37 may be pushed in the desired direction (i.e., clockwise or
  • opening 37 in the cassette will eventually align with the inlet 22 of the shaft
  • the arcuate length of the grooves 54 determine the total amount of the
  • the test strip absorption section is located within the inner cavity 39.
  • test strip 20 eventually delivers an amount of specimen that activates the test strip 20.
  • the horizontal portion of the test strip 20 is readable through the cassette
  • the collar 56 that fits around the test strip may be designed to
  • the cassette's design provides an air lock to keep unwanted sample material from
  • vent openings may aid in air-to-liquid displacement.
  • the vent openings are usually positioned directly over the corresponding inlet or valve opening so that the vent openings are closed when the inlet/valve opening is closed, and are aligned to let air or liquid in when the cassette is rotated in order to activate the test.
  • Detents may be placed proximate the various vent opening(s), to assist in aligning the cassette with respect to the closure and to ensure a snug frictional engagement between the pipe section and the inner wall of the shaft of the closure 14.
  • a plug 70 may be adapted to snap into the interior chamber 28 of
  • the plug 70 includes a control opening 72 that
  • cassette 16 may include a key that matingly engages a key opening 93 in
  • the plug 70 has a unique key opening
  • This plug will be placed near the bottom end of the shaft to seal the
  • the key 93 may help align the plug 70 within the shaft
  • the closure can function as a standard lid
  • a cassette 16 may be inserted into
  • test cassettes 16 will snap into
  • valve opening 37, inlet 22 and plug opening 72 are all aligned (i.e., all three holes must be in proper position to allow the
  • test cassettes same specimen in the sealed container by interchanging the test cassettes. It may be desired to have a sample sealed in a container and after the
  • this procedure reseals the container and shipping the container can be shipped to the remote lab without spilling or contaminating the specimen.
  • the technician at the remote lab may conduct the same test by inserting a fresh cassette into the closure, rotating the cassette in the appropriate direction thereby allowing specimen to flow through inlet 22 and into inner chamber 39. Additional tests may be performed by inserting additional cassettes having the same or different
  • Another embodiment would be to utilize a plug that will
  • the typical use of a chemical reagent test strip includes positioning
  • test strip into a specimen in a small open container, where the test strip
  • test strip is placed onto the holder's sample section, with the entire test strip in a horizontal position.
  • a collar 52 provides a slight pressure to
  • An aspect of the invention is that once the closure and the built-in
  • test cassette are secured to the container 12, a sample specimen in the
  • container can be tested without opening the container.
  • Another aspect is that it provides a means for test personnel to have physical control over the cassette and to physically activate the test when desired. This reduces the
  • the present invention allows the sample specimen to be isolated from
  • Fig. 6 can be adapted with a keyed plug (Fig.6) to prevent the closure from leaking if the cassette is not adapted to the closure. It maybe desired to
  • the keyed plug provides means
  • the window may consist of the entire
  • the cassette cover On the underside of the cassette cover there is a grove that helps position the test strip and positions the test strips absorbent well.
  • the grove may be deeper at the outer edge to encapsulate the heavier absorbent material.
  • the tested specimen from the remaining specimen. This may be desired in cases where there may be legal ramifications that may imply that the tested
  • test cassette may have a rectangular shaped shaft and complimentary cone shapes or any other desired shape, to work with other test cassette
  • closure 14 When closure 14 is placed onto a filled specimen cup with a tapered
  • closure 14 is placed into the cup the specimen will also seeks its level
  • the cone section 184 of the Isolator System may be attached
  • Isolator System is connected to the shaft section 182 before the specimen
  • the windows may be in the open
  • the windows can be
  • the windows can in the closed position and opened by the cassette .
  • the windows can in the closed position and opened by the cassette .
  • an elongated cover 70A may be adapted to
  • the elongated cover 70A performs many of
  • the elongated cover 70 A is not keyed, although when a cassette is
  • the bottom plug 133 of the cover 70A is forced downward when the cassette pushes on the landing area 131 of the cover 70A; simultaneously the entire cover is slid downward aligning the windows 129 and 72 of the cover 70A relative to the gates inlets/outlets of the closure 14. In this position, the sampling /testing apparatus will
  • the windows129 and 72 of the cover are also designed to mate with an
  • the windows 129 and 72 may also be meshed to
  • the cover 70 may also have an alignment control 127.
  • the bottom plug 133 of the cover may incorporate a locking mechanism (not shown) that will latch onto the bottom of the
  • FIG.10 Another embodiment of a cassette with a tapered interior forming a
  • Fig.11 A Special test strip with a tapered lower portion, designed to fit into a tapered cassette or other tapered container.
  • the cassette and test strip as illustrated in Figures 10 and 11 is designed for times when there is only a small amount of a specimen and/or additional reagents added to a test strip.
  • volume may be absorbed into or through the tapered test strip.
  • test strips are designed with a flat bottom.
  • sample specimen is available or desired. There are several test performed in the lab that require a sample specimen and then a few drops of
  • Sampling apparatus can be designed to receive multiple samples and or
  • test strip allowing each to be absorbed through the test strip. This will allow the system to be used for numerous applications such as an HIV, STD's, bacteriological,
  • test strip 140 Pointed end of test strip, designed to fit into a tapered chamber.
  • FIG. 12A a top view of another embodiment of the testing and sampling apparatus using multiple test compartments incorporated into a single test.
  • a cassette cover with viewing window and finger grips 146 is illustrated.
  • Thev finger grips 46 are used to rotate the cassette in order to receive multiple samples and or reagents into the cassette's chamber.
  • Reference positions 142 represent the multiple positions to which the dial may be adjusted to during a test. In this case position a. b. and c.
  • testing apparatus which is adapted to a containerthat has multiple chambers
  • This embodiment may also be designed to be built as
  • chambered container allows the operator to rotate the finger grips 146 on the
  • test strip is being used in the cassettes chamber the samples or reagents can be control to meet the required testing
  • test may utilize a multi-chambered insert or container may be to incorporate a large window that allows a whole blood sample to be applied directly onto an absorbent or test strip. Then afterwards placing the closure with cassette into an multi chambered container. At this point the sample may be treated with reagents and eventually designed to give a visual
  • Multiple openings 148 may be used as vents to displace the contents of inner
  • vents or the inlets/gates will allow interaction or
  • the apparatus includes an outer container having a first end that is open and a second end that is closed, the outer container being capable of holding a liquid specimen; a closure having a top side and a bottom side, the bottom side facing the interior of the container, the closure having means to releasably attach to the first end of the container, the closure includes an elongated tube that extends away from the closure and into the container, said tube having an isolator bottom attached to the distal end of the tube, the isolator bottom having at least one window for allowing at least a portion of any liquid specimen stored in the outer container into the interior of the tube, the closure communicates with the bottom of the outer container via said tube
  • the outer container for isolating said at least portion of the liquid specimen
  • the apparatus further includes a shaft
  • distal end attached to an isolator bottom that partially seals off said distal end
  • the isolator bottom having at least one window that defines a passage from
  • the hollow interior of the shaft communicates with the closure, thereby relating a pathway from
  • an elongated shaft cover having a first end and a second end, said second end of the shaft cover being closed off, said shaft cover having an interior dimension slightly larger than the exterior dimension of the shaft so that the shaft cover functions as a sheath over said shaft and has an initial position that sealedly isolates the interior of the shaft from the interior of the tube; wherein said elongated body section has a sufficiently long longitudinal dimension such that it engages the closed end of the shaft cover before the test cassette is secured to the closure so that when the test cassette is secured to the closure said elongated body section applies a longitudinal force to the shaft cover thereby moving said shaft cover in said pre ⁇

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Pulmonology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un appareil (10) servant à analyser un échantillon.
EP01996075A 2001-10-24 2001-10-24 Appareil d'echantillonnage et d'analyse d'echantillons Ceased EP1438558A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2001/045749 WO2003087776A1 (fr) 2000-10-24 2001-10-24 Appareil d'echantillonnage et d'analyse d'echantillons

Publications (2)

Publication Number Publication Date
EP1438558A1 true EP1438558A1 (fr) 2004-07-21
EP1438558A4 EP1438558A4 (fr) 2008-09-24

Family

ID=32592267

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01996075A Ceased EP1438558A4 (fr) 2001-10-24 2001-10-24 Appareil d'echantillonnage et d'analyse d'echantillons

Country Status (2)

Country Link
EP (1) EP1438558A4 (fr)
AU (1) AU2002227150A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58488C (de) * HÖNEMANN, Ober-Steuer-Controleur, in Hannover, Körnerstrafse 1 IL, und L. MEYER in Hannover, Ernst Auguststr. 5 Probenehmer für Flüssigkeiten
EP0332572A2 (fr) * 1988-01-27 1989-09-13 Will G. Ryan Dispositif de prélèvement d'une fraction d'une série d'échantillons liquides
US5797855A (en) * 1993-11-09 1998-08-25 Hazard; James Taylor Urine specimen and other body fluids collection device
WO1998038917A1 (fr) * 1997-03-05 1998-09-11 Point Of Care Technologies, Inc. Dispositif pour recueillir et analyser des prelevements fluides

Patent Citations (4)

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AU2002227150A1 (en) 2003-10-27

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