EP1434494A1 - Method for preparing animal plasma powder and animal feed thus obtained - Google Patents

Method for preparing animal plasma powder and animal feed thus obtained

Info

Publication number
EP1434494A1
EP1434494A1 EP02765695A EP02765695A EP1434494A1 EP 1434494 A1 EP1434494 A1 EP 1434494A1 EP 02765695 A EP02765695 A EP 02765695A EP 02765695 A EP02765695 A EP 02765695A EP 1434494 A1 EP1434494 A1 EP 1434494A1
Authority
EP
European Patent Office
Prior art keywords
animal
feed
plasma
blood
plasma powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02765695A
Other languages
German (de)
French (fr)
Inventor
Hendrikus Bernardus Johannes Roodink
Theodoor Abram Niewold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harimex BV
Original Assignee
Harimex BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harimex BV filed Critical Harimex BV
Publication of EP1434494A1 publication Critical patent/EP1434494A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/06—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from blood
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/20—Animal feeding-stuffs from material of animal origin
    • A23K10/24—Animal feeding-stuffs from material of animal origin from blood
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Definitions

  • the present invention relates to a method for preparing animal plasma powder by starting from treated animal blood and converting said blood into blood plasma and drying it.
  • the invention furthermore relates to a method for preparing animal feed, in which the usual components of the feed are mixed with an active component.
  • the invention also relates to the animal feed thus obtained.
  • a method for preparing animal plasma powder and incorporating the same into nutritious substances is known from US patent No 6,004,576. It has become apparent that it is possible to stimulate the health and the growth of animals by adding spray-dried animal plasma, generally obtained from pigs, to animal feed.
  • PWD post-weaning diarrhoea
  • PWD a form of diarrhoea which occurs directly after weaning
  • the method according to the present invention is characterized in that the treatment of the blood takes place by immunising the animal with pathogens for the animal in question and/or. components there- of. As a result of said immunisation according to the invention, hyperim- mune blood plasma is obtained.
  • a method for stimulating the health and the growith of animals is obtained by feeding the animals with a feed containing spray-dried plasma powder, which method is characterized in that the animals are fed with an animal feed obtained by using a method as defined in claims 6 - 8.
  • the use of the method according to the present invention not only leads to an improved ingestion of feed and an improved health of the animals, in particular of the (sucking) pigs, as well as to a reduction as regards the occurrence of diarrhoea among sucking pigs after weaning (PWD), but also that the sucking pigs in question secrete fewer diarrhoea-causing bacteria, mainly E.
  • the use of the method according to the present invention not only alleviates the seriousness of the PWD disorder, but it also reduces the extent to which said disorder is spread.
  • the expression "spray-dried hyperimmune porcine plasma powder” is understood to mean spray-dried powder from blood plasma from immunised pigs.
  • the immunised pigs may be immunised with various pathogenic substances or micro-organisms, but in particular with a vaccine containing the so-called F4- factor and/or the heat-unstable toxin (LT) .
  • LT heat-unstable toxin
  • the sucking pigs are fed with a feed which contains 1-15 wt.%, preferably 5-15 wt.%, of spray-dried hyperimmune porcine plasma powder.
  • the present invention also relates to an animal feed containing spray-dried plasma board, in which the animal feed contains spray-dried hyperimmune (porcine) plasma powder.
  • the animal feed may be intended for various animal species, for example for cows, pigs, sheep, poultry and the like, which are important for the agrarian sector.
  • the blood plasma may have been obtained from animals, in particular from pigs that have been immunised with pathogenic substances or micro-organisms for the animal species in question, but also with the aforesaid pathogenic substances or microorganisms for pigs.
  • said animal feed is pig feed, which contains 1-15 wt.%, preferably 5-15 wt.%, of spray-dried hyperimmune pig plasma powder. Experimental research carried out by the applicant shows that satisfactory results are obtained by using the preferred pig feed.
  • the present invention also relates to a method for prepa- ring pig feed, in which porcine plasma powder is dried, preferably spray- dried, and processed together with the other components for said feed.
  • porcine plasma powder is used, and said spray-drying step is carried out in such a manner that maximally 25% of the anti-E coli activity of the hyperimmune plasma is lost.
  • research carried out by the applicant showed that the biological activity of the animal feed containing spray- dried hyperimmune porcine plasma powder is influenced most by the step of spray-drying.
  • the other treatments for example the processing into pellets, do not lead to any appreciable loss of the biological activity.
  • the spray- dried hyperimmune porcine plasma powder contains a titre of 1:500 anti-LT antibodies.
  • the so-called heat-unstable toxin (LT), which is related to the cholera toxin (CT) is an important cause of all kinds of intestinal disorders.
  • CT cholera toxin
  • Animals such as pigs or cows are immunised by administering pathogenic substances, viz. F4-factor, using a method which is known to those skilled in this field.
  • pathogenic substances viz. F4-factor
  • the blood from said ante-mortem and post-, mortem approved, immunised animals is collected in a hygienic manner at a slaughterhouse.
  • the red blood cells are separated from the so-called buffy-coat and other plasma fractions by centrifuging.
  • the plasma fraction and the buffy-coat can be concentrated by means of separation tech- niques such as ultrafiltration, microfiltration, chromatography or precipitation.
  • the pel leti sing step is carried out at a supply temperature of 30 °C. a discharge temperature of about 60 ° C and a rate of 200 kg/hour, so that pellets having a diameter of 3.2 mm are obtained.
  • Example II The method of example I is used, with the immunisation step being carried out with a vaccine containing the heat-unstable toxin (LT) .

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

The present invention relates to a method for preparing animal plasma powder by starting from treated animal blood and converting said blood into blood plasma and drying it, in which the treatment of the blood takes place by immunising the animal with pathogens for the animal in question and/or components thereof. The invention furthermore relates to an animal feed in which the usual components of the feed are mixed with an active component. The invention also relates to the animal feed thus obtained.

Description

METHOD FOR PREPARING ANIMAL PLASMA POWDER AND ANIMAL FEED THUS OBTAINED
The present invention relates to a method for preparing animal plasma powder by starting from treated animal blood and converting said blood into blood plasma and drying it. The invention furthermore relates to a method for preparing animal feed, in which the usual components of the feed are mixed with an active component. The invention also relates to the animal feed thus obtained. A method for preparing animal plasma powder and incorporating the same into nutritious substances is known from US patent No 6,004,576. It has become apparent that it is possible to stimulate the health and the growth of animals by adding spray-dried animal plasma, generally obtained from pigs, to animal feed. This leads in particular to an improved ingestion of feed and a reduction in the occurrence of the so-called "post-weaning diarrhoea", a form of diarrhoea which occurs directly after weaning (hereinafter abbreviated PWD). Consequently it is one of the objectives of the invention to alleviate the seriousness of the PWD disorder, which is caused as such by a bacterial infection. The PWD disorder leads to significant losses within the agrarian sector in question.
The method according to the present invention is characterized in that the treatment of the blood takes place by immunising the animal with pathogens for the animal in question and/or. components there- of. As a result of said immunisation according to the invention, hyperim- mune blood plasma is obtained.
Furthermore according to the invention, a method for stimulating the health and the growith of animals is obtained by feeding the animals with a feed containing spray-dried plasma powder, which method is characterized in that the animals are fed with an animal feed obtained by using a method as defined in claims 6 - 8. Research carried out by the applicant has shown that the use of the method according to the present invention not only leads to an improved ingestion of feed and an improved health of the animals, in particular of the (sucking) pigs, as well as to a reduction as regards the occurrence of diarrhoea among sucking pigs after weaning (PWD), but also that the sucking pigs in question secrete fewer diarrhoea-causing bacteria, mainly E. col i bacteria, in their excrements, and that as a result less infection occurs in the group of which the sucking pigs in question form part. Thus, the use of the method according to the present invention not only alleviates the seriousness of the PWD disorder, but it also reduces the extent to which said disorder is spread.
Within the framework of the present invention the expression "spray-dried hyperimmune porcine plasma powder" is understood to mean spray-dried powder from blood plasma from immunised pigs. The immunised pigs may be immunised with various pathogenic substances or micro-organisms, but in particular with a vaccine containing the so-called F4- factor and/or the heat-unstable toxin (LT) .
According to a preferred application of the present method, the sucking pigs are fed with a feed which contains 1-15 wt.%, preferably 5-15 wt.%, of spray-dried hyperimmune porcine plasma powder.
The present invention also relates to an animal feed containing spray-dried plasma board, in which the animal feed contains spray-dried hyperimmune (porcine) plasma powder. The animal feed may be intended for various animal species, for example for cows, pigs, sheep, poultry and the like, which are important for the agrarian sector. The blood plasma may have been obtained from animals, in particular from pigs that have been immunised with pathogenic substances or micro-organisms for the animal species in question, but also with the aforesaid pathogenic substances or microorganisms for pigs. According to a preferred embodiment said animal feed is pig feed, which contains 1-15 wt.%, preferably 5-15 wt.%, of spray-dried hyperimmune pig plasma powder. Experimental research carried out by the applicant shows that satisfactory results are obtained by using the preferred pig feed.
The present invention also relates to a method for prepa- ring pig feed, in which porcine plasma powder is dried, preferably spray- dried, and processed together with the other components for said feed. In accordance with the method according to the present invention, hyperimmune porcine plasma powder is used, and said spray-drying step is carried out in such a manner that maximally 25% of the anti-E coli activity of the hyperimmune plasma is lost. Research carried out by the applicant showed that the biological activity of the animal feed containing spray- dried hyperimmune porcine plasma powder is influenced most by the step of spray-drying. The other treatments, for example the processing into pellets, do not lead to any appreciable loss of the biological activity. According to an especially preferred embodiment, the spray- dried hyperimmune porcine plasma powder contains a titre of 1:500 anti-LT antibodies. The so-called heat-unstable toxin (LT), which is related to the cholera toxin (CT) , is an important cause of all kinds of intestinal disorders. The invention will be explained in more detail hereinafter by means of the following examples. Example I
Animals such as pigs or cows are immunised by administering pathogenic substances, viz. F4-factor, using a method which is known to those skilled in this field. The blood from said ante-mortem and post-, mortem approved, immunised animals is collected in a hygienic manner at a slaughterhouse. The red blood cells are separated from the so-called buffy-coat and other plasma fractions by centrifuging. The plasma fraction and the buffy-coat can be concentrated by means of separation tech- niques such as ultrafiltration, microfiltration, chromatography or precipitation. Also other techniques may be used for removing undesirable substances (as mentioned in EP-B-0438 196) before a fraction is stabilised by carrying out a drying step, such as spray-drying or freeze-drying. The equipment that is used meets the hygienic requirements that apply in the foodstuffs industry and/or the pharmaceutical industry. 8 kg of the immunised, dried blood plasma thus obtained is added to 100 kg of a usual animal feed and mixed therewith. The animal feed contains as its main components 48 wt.% barley, 28 wt.% wheat, 7 wt.% soybean flour, 6% lactose, 4% fat, with the remainder including a ino acids, calcium phosphate, salt and molasses. The pel leti sing step is carried out at a supply temperature of 30 °C. a discharge temperature of about 60 °C and a rate of 200 kg/hour, so that pellets having a diameter of 3.2 mm are obtained. Example II The method of example I is used, with the immunisation step being carried out with a vaccine containing the heat-unstable toxin (LT) .

Claims

1. A method for preparing animal plasma powder by starting from treated animal blood and converting said blood into blood plasma and drying it, characterized in that the treatment of the blood takes place by immunising the animal with pathogens for the animal in question and/or components thereof.
2. A method according to claim 1, characterized in that the step of preparing hyperimmune porcine plasma powder is carried out.
3. A method according to claims 1 - 2, characterized in that the step of drying the blood plasma is carried out by spray-drying.
4. A method according to claims 1 - 3, characterized in that said immunisation step is carried out with a vaccine containing the F4-factor and/or the heat-unstable toxin (LT).
5. A method according to claims 1 - 4, characterized in that said (spray) drying step is carried out in such a manner that maximally 25% of the anti-E coli activity of the hyperimmune plasma is lost.
6. A method for preparing animal feed, in which the usual components of the feed are mixed with an active component, characterized in that said active component is a hyperimmu- ne animal plasma powder obtained by carrying out the method according to claims 1 - 5.
7. A method according to claim 6, characterized in that said method is based on the use of porcine plasma.
8. A method according to claims 5 - 7, characterized in that a pig feed is prepared.
9. A method for stimulating the health and the growith of animals is obtained by feeding the animals with a feed containing plasma powder, characterized in that the animals are fed with an animal feed obtained by using a method as defined in claims 6 - 8.
10. A method according to claim 9, characterized in that said animal is a pig.
11. A method according to claim 10, characterized in that said animal is a (sucking) pig.
12. A method according to claims 9 - 11, characterized in that said feed contains 1-15 wt.% dried hyperimmune plasma powder.
13. An animal feed containing dried plasma powder, characterized in that said animal feed contains animal plasma powder prepared by carrying out the method defined in claims 1 - 5.
14. An animal feed according to claims 13 - 14, characterized in that said feed ; contains 1-15 wt.% dried hyperimmune plasma powder.
15. An animal feed according to claims 13 - 15, characterized in that said feed is in the form of pellets.
EP02765695A 2001-10-08 2002-10-07 Method for preparing animal plasma powder and animal feed thus obtained Withdrawn EP1434494A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL1019142A NL1019142C2 (en) 2001-10-08 2001-10-08 Method for the preparation of animal plasma powder, method for promoting the health and growth of animals and the animal feed thus obtained.
NL1019142 2001-10-08
PCT/NL2002/000641 WO2003030654A1 (en) 2001-10-08 2002-10-07 Method for preparing animal plasma powder and animal feed thus obtained

Publications (1)

Publication Number Publication Date
EP1434494A1 true EP1434494A1 (en) 2004-07-07

Family

ID=19774151

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EP02765695A Withdrawn EP1434494A1 (en) 2001-10-08 2002-10-07 Method for preparing animal plasma powder and animal feed thus obtained

Country Status (3)

Country Link
EP (1) EP1434494A1 (en)
NL (1) NL1019142C2 (en)
WO (1) WO2003030654A1 (en)

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Publication number Priority date Publication date Assignee Title
US8092853B2 (en) 2003-12-02 2012-01-10 Purina Mills, Llc Gel based livestock feed, method of manufacture and use
WO2010117976A1 (en) 2009-04-09 2010-10-14 Entegrion, Inc Spray-dried blood products and methods of making same
US8407912B2 (en) 2010-09-16 2013-04-02 Velico Medical, Inc. Spray dried human plasma
US20110142885A1 (en) 2009-09-16 2011-06-16 Velico Medical, Inc. Spray-dried human plasma
CA2816090A1 (en) 2010-10-29 2012-05-03 Velico Medical, Inc. System and method for spray drying a liquid
US20140083628A1 (en) 2012-09-27 2014-03-27 Velico Medical, Inc. Spray drier assembly for automated spray drying
US9561184B2 (en) 2014-09-19 2017-02-07 Velico Medical, Inc. Methods and systems for multi-stage drying of plasma
CN111871625A (en) * 2020-07-15 2020-11-03 江苏永盛生物科技有限公司 Preparation process and device of low-ash porcine plasma protein powder
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system
US11975274B2 (en) 2022-09-15 2024-05-07 Velico Medical, Inc. Blood plasma product

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SE374811B (en) * 1973-01-18 1975-03-17 Sintab Swedinventor Ab
CA1046407A (en) * 1975-06-20 1979-01-16 Canada Packers Limited Dried particulate animal serum of reduced saline content
JPS6240251A (en) * 1985-08-16 1987-02-21 Ito Ham Kk Feed for piglet
US5575999A (en) * 1993-12-03 1996-11-19 Ampc, Inc. Animal feed supplement containing co-sprayed dried plasma protein and amylase
US5785990A (en) * 1995-07-10 1998-07-28 Merrick's, Inc. Feed fortifier and enhancer for preruminant calves and method of using same
US6004576A (en) * 1997-08-11 1999-12-21 Ampc, Inc. Granular plasma protein supplement with increased bio-efficacy

Non-Patent Citations (1)

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Title
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Also Published As

Publication number Publication date
NL1019142C2 (en) 2003-04-09
WO2003030654A1 (en) 2003-04-17

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