EP1432796A4 - Stable episomal vectors - Google Patents

Stable episomal vectors

Info

Publication number
EP1432796A4
EP1432796A4 EP02759488A EP02759488A EP1432796A4 EP 1432796 A4 EP1432796 A4 EP 1432796A4 EP 02759488 A EP02759488 A EP 02759488A EP 02759488 A EP02759488 A EP 02759488A EP 1432796 A4 EP1432796 A4 EP 1432796A4
Authority
EP
European Patent Office
Prior art keywords
episomal vectors
stable episomal
stable
vectors
episomal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02759488A
Other languages
German (de)
French (fr)
Other versions
EP1432796A1 (en
Inventor
Thomas E Wagner
Xianzhang Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1432796A1 publication Critical patent/EP1432796A1/en
Publication of EP1432796A4 publication Critical patent/EP1432796A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP02759488A 2001-08-30 2002-08-30 Stable episomal vectors Withdrawn EP1432796A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31569801P 2001-08-30 2001-08-30
US315698P 2001-08-30
PCT/US2002/027542 WO2003020926A1 (en) 2001-08-30 2002-08-30 Stable episomal vectors

Publications (2)

Publication Number Publication Date
EP1432796A1 EP1432796A1 (en) 2004-06-30
EP1432796A4 true EP1432796A4 (en) 2004-12-22

Family

ID=23225651

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02759488A Withdrawn EP1432796A4 (en) 2001-08-30 2002-08-30 Stable episomal vectors

Country Status (4)

Country Link
US (1) US7294505B2 (en)
EP (1) EP1432796A4 (en)
CA (1) CA2459269A1 (en)
WO (1) WO2003020926A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2536026A1 (en) * 2003-08-22 2005-05-06 Nucleonics Inc. Eukariotic expression systems for expression of inhibitory rna in multiple intracellular compartments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591601A (en) * 1993-05-14 1997-01-07 Ohio University Edison Animal Biotechnology Institute DNA polymerase gene expression system utilizing an RNA polymerase co-delivered with the gene expression vector system
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
WO1999025831A2 (en) * 1997-11-14 1999-05-27 The Regents Of The University Of California Slit polypeptide and method of modulation of robo with ligands

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BRISSON M ET AL: "A novel T7 RNA polymerase autogene for efficient cytoplasmic expression of target genes", GENE THERAPY, vol. 6, no. 2, February 1999 (1999-02-01), pages 263 - 270, XP002302503, ISSN: 0969-7128 *
CRAENENBROECK VAN K VANHOENACKER P HAEGEMAN G: "Episomal vectors for gene expression in mammalian cells", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 267, 2000, pages 5665 - 5678, XP002954557, ISSN: 0014-2956 *
LANGLE-ROUAULT F ET AL: "UP TO 100-FOLD INCREASE OF APPARENT GENE EXPRESSION IN THE PRESENCEOF EPSTEIN-BARR VIRUS ORIP SEQUENCES AND EBNA1: IMPLICATIONS OF THENUCLEAR IMPORT OF PLASMIDS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 72, no. 7, July 1998 (1998-07-01), pages 6181 - 6185, XP002924894, ISSN: 0022-538X *
See also references of WO03020926A1 *
WANG S ET AL: "A NOVEL HERPESVIRUS AMPLICON SYSTEM FOR IN VIVO GENE DELIVERY", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 4, no. 11, November 1997 (1997-11-01), pages 1132 - 1141, XP000964755, ISSN: 0969-7128 *

Also Published As

Publication number Publication date
EP1432796A1 (en) 2004-06-30
CA2459269A1 (en) 2003-03-13
US20030064472A1 (en) 2003-04-03
WO2003020926A1 (en) 2003-03-13
US7294505B2 (en) 2007-11-13

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20040329

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AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 12N 15/85 B

Ipc: 7A 61K 31/70 B

Ipc: 7A 01N 43/04 B

Ipc: 7C 12N 15/74 B

Ipc: 7C 12N 15/70 B

Ipc: 7C 12N 15/63 B

Ipc: 7C 12N 15/09 B

Ipc: 7C 12N 15/00 A

A4 Supplementary search report drawn up and despatched

Effective date: 20041108

17Q First examination report despatched

Effective date: 20050203

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071207