EP1429721A1

EP1429721A1 - Skin and hand care agents

Info

Publication number: EP1429721A1
Application number: EP01274496A
Authority: EP
Inventors: Marcel Veeger; Andreas Klotz; Gerda Maehse; Beatrice HÄUSLER; Karin Faensen
Original assignee: Stockhausen GmbH and Co KG; Chemische Fabrik Stockhausen GmbH
Current assignee: Evonik Operations GmbH
Priority date: 2001-09-20
Filing date: 2001-09-20
Publication date: 2004-06-23
Also published as: US7241452B2; WO2003026609A1; US20040247557A1

Abstract

The invention concerns aqueous agents for skin and hand care, compatible with the skin and having good cleansing effect. Said agents are characterized in that they contain 10 to 60 wt. % of one or more triglycerides, saturated or unsaturated fatty acids or mixtures thereof, 5 to 40 wt. % of at least a fatty alcohol ethoxylate, 10 to 65 wt. % of water, 0 to 30 wt. % of one or more abrasives, relative to the composition of the cleansing agents, and optionally one or more viscosity agents and other auxiliary agents, additives of active cosmetic agents.

Description

Skin and hand cleanser

The invention relates to water-containing skin and hand cleaning agents, in particular "waterless hand cleaners" with improved dermatological compatibility and the use of the agents for removing extreme dirt.

Skin and hand cleaning agents are used extensively in industry, especially where stubborn soiling occurs, which is caused by paints, greases, oils, lubricants, metal dusts, graphite, soot and others. are caused.

Such cleaning agents are known per se as so-called coarse hand cleaners (cf. H. Tronnier, J. Kresken, K. Jablonski, B. Komp, "Haut und Beruf", Grosse Verlag, Berlin, pp. 75-108 [1989]). These are usually preparations which contain an abrasive, surfactant / surfactant mixtures, thickeners and, if appropriate, auxiliaries for regulating the consistency, appearance, odor and stability, such as pigments, fragrances, stabilizers and preservatives. For particularly stubborn dirt, there are products in which the use of the above-mentioned ingredients is not sufficient. Organic solvents are added to these preparations, e.g. aliphatic hydrocarbons, terpenes, carboxylic acid esters of the dimethyl adipate type, dimethyl glutarate, dimethyl succinate (DBE) and di-n-butyl adipate or di-isopropyl adipate, as described in DE 4335933 A1.

In this context, reference is made here to the so-called "waterless cleaners" available on the market, the good cleaning action of which is based primarily on the abovementioned organic solvents, in particular petrol, kerosene, short-chain paraffin oils. Commercial "waterless cleaners" have the following composition:

Petroleum distillates: 35.0 to 45.0% by weight

Water: 30.0 to 35.0% by weight

Mineral oils: 10.0 to 20.0% by weight

Sodium oleate: 10.0 to 20.0% by weight

Trideceth-9: 1.0 to 5.0% by weight propylene glycol: 1.0 to 5.0% by weight Petrolatum: 1.0 to 5.0% by weight

Lanolin: 1.0 to 5.0% by weight

Zinc pyrithione: 0.1 to 1.0% by weight

Further examples of such solvent-containing "waterless cleaners" can be found in Ernest W. Flick, "Cosmetic and Toiletry Formulations", Second Edition, 1989, pages 737 to 744. Such coarse hand cleaners are used without the addition of water, the cleaning being carried out exclusively with the product and a drying cloth.

The more often such products are used on the skin in the industrial sector (up to 6 times and more often a day), the more clearly the adverse effects of the surfactants and especially the solvents occur, namely the degreasing and drying out of the skin through the destruction of the hydro-lipid Coat of the skin, in the foreground. This leads to increased absorption of toxic and allergenic substances or to microorganisms or, as a result, to toxic or allergenic skin reactions.

WO 99/06021 describes water-containing "waterless handcleaner" formulations which have a water content of 75 to 99% by weight, up to 25% by weight of a fatty acid ester or mixtures of such esters and at least one surfactant. Formulations of this type are a significant improvement over the previously mentioned products containing organic solvents, in particular from a toxicological point of view. Nonetheless, the improved skin tolerance and the improved protection against drying out of the skin went hand in hand with a loss of cleansing action in comparison to these solvent-containing "waterless cleaners" or Coarse hand cleaner containing solvents.

DE 4424210 A 1 describes water-free shower oils which contain at least 45% by weight of oil selected from the group of oils with a high content of triglycerides, saturated and / or unsaturated fatty acids, such as soybean oil, sunflower oil, wheat germ oil, and a maximum of 55% by weight. % Surfactants, preferably monoisopropanolamine lauryl ether sulfate (MIPA), laureth sulfate, laureth-4 and coconut fatty acid diethanolamide. A disadvantage of these preparations is that the cleaning action of such shower oils is not sufficient to withstand extreme contamination, such as that of coarse hand cleaners is required to remove. In addition, the preparations contain fatty acid mono- or diethanolamide, which, according to Fiedler, Edito Cantor Verlag, 4th edition, 1996, p. 376, is known to be a risk of sensitization.

Water-containing shower preparations are known from EP 0769292 A 1, with rapeseed oil or rapeseed oil derivatives being used as skin care components in addition to surfactant mixtures. Because of the lack of cleaning power, these agents are also unsuitable as coarse hand cleaners, in particular also because such shower preparations have to meet a different requirement profile with regard to consumer acceptance than with coarse hand cleaners, which focus on the cleaning performance of the product.

DE 19748 921 A1 relates to water-containing liquid, pasty or cream-shaped hand cleaning agents, in particular coarse hand cleaning agents with a rubbing agent, which have a content of 10 to 30% by weight of at least one vegetable oil, selected from the group consisting of triglycerides, saturated and / or unsaturated fatty acids , from 10 to 30% by weight of at least one surfactant from the group consisting of fatty alcohol ethoxylates, fatty alcohol ether sulfates and / or castor oil sulfonates and 10 to 65% by weight of water, in each case based on the composition of the cleaning agents. As a coarse hand cleaner, these compositions contain 1 to 30% by weight of at least one abrasive in the composition. The coarse hand cleaners described there are very well tolerated by the skin from a dermatological point of view and, even if they are used several times a day, only have a slight drying out of the skin.

In view of the diverse fields of application, however, there is still a need for skin or hand cleaning agents which are free from organic solvents and abrasives and a cleaning action in the case of water-free use, ie as a "waterless cleaner" comparable to solvent-containing cleaning agents or for use with water show a cleaning effect comparable to that of the coarse hand cleaners described in DE 19748 921 A1, with good skin tolerance and low skin drying out at the same time. The task was therefore to provide such skin and hand cleaning agents, in particular rough hand cleaning agents. This task was surprisingly achieved by a skin and hand cleaning agent that contains

a.). 10 to 60% by weight of one or more triglycerides, saturated and / or unsaturated fatty acids, based on the composition of the cleaning agent, b.) 5 to 40% by weight, based on the composition of the cleaning agent, of at least one fatty alcohol ethoxylate c.) 10 to 65% by weight of water, based on the composition of the cleaning agent, d.) 0 to 30% by weight, based on the composition of the cleaning agent, of one or more abrasives, e.) Optionally one or more viscosity-forming agents , f.) if appropriate, further cosmetic auxiliaries, additives and / or active ingredients,

the sum of components a) to f) being 100% by weight.

The triglycerides, saturated and / or unsaturated fatty acids to be used according to the invention can be produced synthetically or from naturally occurring oils, such as e.g. animal fats or vegetable oils originate, the latter being correspondingly industrially prepared or cleaned for cosmetic use. Vegetable oils are particularly preferred here. Preferred vegetable oils are, for example, safflower oil, olive oil, avocado oil, coconut oil, cottonseed oil, menhaden oil, palm kernel oil, palm oil, peanut oil, soybean oil, rapeseed oil, linseed oil, rice palm oil, pine oil, sesame oil, wheat germ oil, cowslip oil and sunflower oil. The oils can be used alone or as mixtures, vegetable oils, in particular rapeseed oil, soybean oil and / or linseed oil or a mixture thereof, being particularly preferred.

The triglycerides, saturated, unsaturated fatty acids and / or mixtures thereof are contained in the skin and hand cleansing agents according to the invention in an amount of 10 to 60% by weight, preferably 25 to 55% by weight and particularly preferably 40 to 45% by weight, in the preferred embodiment, the triglycerides used have a higher proportion of unsaturated fatty acids. The fatty alcohol ethoxylates used as component b.) Preferably have the general formula

R-O- (CH2-CH2-O) nH

on, where

R = saturated, unsaturated, branched or unbranched alkyl radical, n = integer from 1 to 11.

R = C8 to C18, in particular C10 to C16 and particularly preferably C11 to, are preferably used as the saturated, unsaturated, branched or unbranched alkyl radical

C14 is used, preferably n = 3 to 6, in particular n = 5 to 7.

I.

The skin and hand cleaning agents according to the invention contain 5 to 40% by weight, preferably 10 to 35 and particularly preferably 15 to 30% by weight, of fatty alcohol ethoxylates, based on the composition of the cleaning agent. In a preferred embodiment, the skin and hand cleaning agents according to the invention contain 15 to 25% by weight, based on the composition of the cleaning agent, of Laureth-6 as fatty alcohol ethoxylate.

The skin and hand cleaning agents according to the invention, which are free from organic solvents, contain 10 to 65, based on the composition of the cleaning agent, 20 to 50 and particularly preferably 20 to 35% by weight of water.

Although the skin and hand cleaning agents according to the invention have a very good cleaning action, so that the addition of abrasives to these cleaning agents is unnecessary, the skin and hand cleaning agents can optionally contain abrasives for certain cleaning applications. The proportion of the abrasive or abrasives can then contain 1 to 30, based on the composition of the cleaning agent, preferably 10 to 20% by weight. Abrasives to be used with preference are, for example, plastic rubbing agents based on polyethylene or polyurethane, abrasives based on natural kernel and / or shell flours, in particular walnut shell, almond shell, hazelnut shell, olive kernel, apricot kernel and cherry kernel flour or any mixtures these shell and core flours and pearls from waxes, such as jojoba waxes, with walnut shell flour bleached with hydrogen peroxide being particularly preferred. In a further embodiment of the invention, the skin and hand cleansing agents optionally contain one or more viscosity-forming agents such as, for example, organophilic and / or hydrophilic phyllosilicates, in particular bentonites, polysaccharides, such as, for example, cellulose, guar gum and / or xanthans, modified polysaccharides, preferably cellulose ethers, carboxymethyl cellulose and / or hydroxyalkyl celluloses, preferably hydroxyethyl cellulose and / or inorganic electrolytes, preferably sodium chloride and / or magnesium sulfate.

The skin and hand cleansing agents according to the invention can optionally contain further cosmetic auxiliaries, additives and / or active ingredients, for example pH regulators, stabilizers, preferably cetearyl alcohol and / or hydrogenated castor oils, such as e.g. Trihydroxystearin, fragrances, preservatives, preferably organic acids and antioxidants, e.g. Contain vitamin E acetate. Oily or aqueous care components such as e.g. Bisabolol, aloe vera, panthenol, sodium PCA, jojoba oil etc. can be used to underline the care effect.

The skin and hand cleansing agents according to the invention, in particular coarse hand cleaners, are usually produced by means of known devices in a batch or continuous process, the skin and hand cleansing agents preferably being obtained as creamy agents or as flowable viscous pastes. Suitable devices are temperature-controlled kettles with stirrers, mixers and extruders.

The skin and hand cleaning agents according to the invention are used by first distributing the cleaning agent on the skin, preferably without water, and then wiping with a cloth, preferably a disposable article made of paper, plastic or textile fabric, etc., without water. However, application with the aid of water is also possible. The product is rinsed off together with the dirt. In the former case, one speaks of a so-called "leave on" product. Good dermatological compatibility is particularly important for this, which is achieved with the skin and hand cleansing agents according to the invention.

The skin and hand cleansing agents according to the invention, in particular coarse hand cleaners, are used to remove coarse soiling that strongly adheres to the skin, such as fats, oils and other lubricants, paints, varnishes, tar, graphite, carbon black, color pigments and similar substances as they are used in industrial and public areas Area, in the craft, in agriculture as well as in the household. The skin and hand cleaning agents according to the invention are particularly advantageous when cleaning the most stubborn paint soiling if the proportion of triglycerides in the composition of the compositions is greater than the proportion of fatty alcohol ethoxylate, the detergent here comprising at least 15% by weight, based on the composition, Should contain fatty alcohol ethoxylates.

Particularly preferred skin and hand cleaning agents are agents which contain at least 40% by weight of rapeseed oil and at least 20% by weight, based on the composition of the cleaning agent, of fatty alcohol ethoxylates, preferably Laureth-6.

It has surprisingly been found that, despite the use of fatty alcohol ethoxylates, which are primarily responsible for the cleaning action in the skin and hand cleansing agents according to the invention, in particular in the case of paint soiling, they dry the skin more strongly when used topically, so that skin tolerance decreases, this can be compensated according to the invention by a higher proportion of triglycerides. Without the addition of mild surfactants, e.g. Fatty alcohol ether sulfates or sulfated castor oils, which must be present in the hand cleaner formulations described in DE 19748 921, could be used in anhydrous form, i.e. As a "waterless cleaner" of the skin and hand cleaning agents according to the invention, a cleaning effect can be achieved which is comparable to solvent-based cleaning agents or, when used with water, has a cleaning effect comparable to that of the coarse hand cleaners described in DE 19748 921 A1, with good skin tolerance and less Dehydration of the skin, although the skin and hand cleaning agents according to the invention are free from organic solvents and abrasives.

The invention is described by the following examples and tests, such as skin compatibility test using the Duhring chamber test, skin drying using the corneometer and cleaning power using the hand washing test. Test Methods

The skin compatibility test is carried out using the Duhring chamber test according to P.J. Frosch, A.M. Kligman, Contact Dermatities 5, page 73, 1979; modified from J.

Kresken, W.S. Wassilew, H + G4, page 334, 1992; A. Klotz, Am. J. Cont. Derm., 2001, 12 (1), page 52 and A. Klotz, M. Veeger, Pharm. Ztg. 2000, 145 (35), pages 47 to 51.

This method is an in vivo test model for checking the skin tolerance of different test products in a direct comparison. The test subjects are applied to the test area in 4 air-tight aluminum chambers on the volar side of the forearms for 4 days in a row. The resulting skin irritation is assessed according to the scale given below or the application time 1 day after the last product application.

R = redness (erythema): 0 = no erythema 4 = severe erythema S = scaling: 0 = no scaling 4 = strong scaling F = fissures: 0 = no fissures 3 = strong fissures

The result are the assessment criteria

1. Irritation x as the mean of the sum of the irritation values of R, S and F of the n subjects

2. Application time h as the mean value of the tolerated application time in hours of the n subjects.

The relative skin tolerance (A value) can be calculated from these two values using the following formula: h

A =

Λ] X

It is thus possible to describe a relation between the application time and the irritation that occurred during this time with a value. As an aid to the appraisal The following table can be used to determine the skin tolerance of the tested products: A value:

> 23 excellent skin tolerance 18 - 23 very good skin tolerance 13 - 18 good skin tolerance 8 - 13 satisfactory skin tolerance 3 - 8 sufficient skin tolerance <3 poor skin tolerance

Examination of skin dehydration using the corneometer

The comeometer measurement is a non-invasive capacitive measurement method for assessing the moisture status of the uppermost skin layers of the stratum comeum. For skin-healthy subjects, this is largely determined by external influences. , .

Frequent skin cleaning leads to degreasing of the skin and thus to a decrease in moisture in the uppermost layers of the skin. The decrease in the moisture content of the skin represents a deterioration in the skin condition and causes an increased risk of eczema. This effect can be achieved with the comeometer e.g. the CM 825 from Courage & Khazaka Electronic GmbH, Cologne, can be measured.

Before starting the test, the initial values (C ₀ ) are determined and at the end of the test the final values (C _π ) are determined. The change in skin moisture C is calculated as follows: C = (C _n - C ₀ )

Negative values mean an increase in skin moisture, positive values mean a decrease in skin moisture.

Check the cleaning power using the hand wash test

The test model of the hand wash test with standardized dirt or varnish provides information about the cleaning effect of the products to be tested. For practical relevance, it is necessary that all subjects have a characteristic, manual Work-related skin structure of the palms of the hands. The following test is carried out in the morning and in the afternoon with one product each:

Test execution with water:

5

- 0.5 g of dirt (model dirt, practice dirt or paint) is distributed and rubbed on the palm and on the back of the hand - 1 V min. Let dry - 1, 2 g of cleaning agent are applied and rubbed in

.0 - 1 ml of water is added and washed for 30 s

- Add another 1 ml of water and wash for 30 s

- rinse under running cold water

- Visual assessment of residual dirt (RV) on the back of the hand and the palm of the hand according to the scale below.

L5

Test execution without water:

- 0.5 g of dirt (model dirt, practice dirt or paint) is distributed and rubbed on the palm and on the back of the hand .0 - 1 Vz min. let dry

- 1, 2 g cleaning agent are applied and rubbed

- with cellulose paper, the dirt on the palms of the hands are removed together with the product ..;

- Visual assessment of residual dirt (RV) on the back of the hand and the inside surface according to the scale below.

0 = clean 5 = no cleaning effect (gradation in steps of 0.5 possible)

The percentage cleaning effect is calculated using the following formula:

0 cleaning effect [%] = ^1Q - ( ^RV ^ ° ^{+ RV} ^) * ₁₀₀ %

R inner = mean value of residual contamination on the palms of hands from n series of measurements (test persons)

RVoutside = mean value of residual soiling on the outer surfaces of hands from n series of measurements (subjects) Since the determination of the cleaning effect as a result of the test method has a larger fluctuation range, an absolute deviation of 5% between two series of measurements is permissible.

Composition of a suitable model pollution:

Mptpröl: 54.15%

Vaseline: 18.05%

Wool wax: 18.05%

Graphite: 3.61%

Soot: 5.42%

Iron oxide (Fe2Ü3): 0.72%

EXAMPLES

Skin and hand cleansing agents according to the compositions given in Table 1 were produced by stirring all the components together using the cold-cold, hot-cold or hot-hot processes customary in cosmetics, up to a maximum of 70 ° C. The agents were characterized in terms of their skin tolerance, skin drying and cleaning effect against model dirt and paint.

The example formulations 1 to 6 according to the invention have a comparable, very good skin tolerance in the described skin tolerance test in comparison to the solvent-free comparison formulation No. 7, which was produced in accordance with W / O 99/06021, and a comparable skin drying out after cleaning in the comeometer test , In contrast, the skin tolerance of the example formulations 1 to 6 according to the invention is significantly better compared to the solvent-based, commercially available comparison product No. 8.

In addition, the formulations 1 to 6 according to the invention showed a comparable, very good cleaning effect in the described, standardized cleaning test in comparison with the solvent-containing comparative product No. 8 with respect to paint contamination and with respect to model contamination. However, the cleaning effect of the example formulations 1 to 6 according to the invention is significantly better in comparison to the very skin-compatible, solvent-free formulation No. 7. according to WO 99/06021. Table 1:

Claims

claims

1. Skin and hand cleanser characterized by a content of

a.) 10 to 60 wt .-% of one or more triglycerides, saturated, unsaturated fatty acids and / or their. Mixtures, based on the composition of the cleaning agent, b.) 5 to 40% by weight, based on the composition of the cleaning agent, of at least one fatty alcohol ethoxylate c.) 10 to 65% by weight of water, based on the composition of the cleaning agent, d. ) 0 to 30% by weight, based on the composition of the cleaning agent, one or more abrasives, e.) Optionally one or more viscosity-forming agents, f.) Optionally further cosmetic auxiliaries, additives and / or active ingredients,

the sum of components a) to f) being 100% by weight.

2. Skin and hand cleanser according to claim 1, characterized in that the triglycerides, saturated, unsaturated fatty acids and / or mixtures thereof to 25 to 55 wt .-%, preferably 40 to 45 wt .-%, based on the additive composition of the cleaning agent, contained in the agent.

3. Skin and hand cleanser according to claim 1 or 2, characterized in that the triglycerides, saturated, unsaturated fatty acids and / or their mixtures are synthetically produced and / or come from naturally occurring fats and / or oils.

4. skin and hand cleaning agent according to claims 1 to 3, characterized in that the agent vegetable oils, in particular. Contains rape oil, soybean oil and / or linseed oil or a mixture thereof.

5. skin and hand cleaning agent according to claims 1 to 4, characterized in that the agent contains 10 to 35, preferably 15 to 30 wt .-% at least one fatty alcohol ethoxylate.

6. skin and hand cleanser according to claims 1 to 5, characterized in that the agent fatty alcohol ethoxylates of the general formula

R-0- (CH2-CH2-) nH contains, where

7. skin and hand cleaning agent according to claims 1 to 6, characterized in that the agent, based on the composition of the cleaning agent, contains 20 to 50, preferably 25 to 35 wt .-% water.

8. skin and hand cleaning agent according to claims 1 to 7, characterized in that the abrasive content is 0 to 30 wt .-%, preferably 10 to 20 wt .-% ..

9. skin and hand cleaning agent according to claims 1 to 8, characterized in that the agent as an abrasive plastic rubbing agent based on polyethylene or polyurethane and / or rubbing agent based on natural core and / or shell powder and / or pearls from waxes contains.

10. skin and hand cleanser according to claims 1 to 9, characterized in that the agent as a viscosity-forming agent organophilic and / or hydrophilic phyllosilicates and / or polysaccharides, in particular cellulose, guar gum and / or xanthans, modified polysaccharides, preferably cellulose ether, Contains carboxymethyl cellulose and / or hydroxyalkyl celluloses, and / or inorganic electrolytes.

11. Skin and hand cleaning agent according to claims 1 to 10, characterized in that the agent as a cosmetic auxiliary, additive and / or active ingredients pH

Regulators, stabilizers, preferably cetearyl alcohol and / or hydrogenated castor oils, fragrances, preservatives, preferably organic acids, in particular citric acid, antioxidants, and / or oily or aqueous care components, preferably bisabolol, aloe vera, panthenol and jojoba oil.

12. Skin and hand cleaning agent according to claims 1 to 11, characterized in that the agent contains 15 to 25 wt .-%, based on the composition of the cleaning agent, Laureth-6 as fatty alcohol ethoxylate.

13. Use of the skin and hand cleaning agents according to claims 1 to 12, characterized in that the agents are used without additional use of water with the aid of a cloth, preferably a disposable article for skin or hand cleaning.

14. Use of the skin and hand cleaning agents according to claims 1 to 12, characterized in that the agents are used with water for skin or hand cleaning.