EP1423119A4 - Ligands de liaison avec les proteines de fixation de fk-506 heterobicycles - Google Patents
Ligands de liaison avec les proteines de fixation de fk-506 heterobicyclesInfo
- Publication number
- EP1423119A4 EP1423119A4 EP02731761A EP02731761A EP1423119A4 EP 1423119 A4 EP1423119 A4 EP 1423119A4 EP 02731761 A EP02731761 A EP 02731761A EP 02731761 A EP02731761 A EP 02731761A EP 1423119 A4 EP1423119 A4 EP 1423119A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- heterobicycles
- fkbp
- ligands
- heterobicycles fkbp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28982801P | 2001-05-10 | 2001-05-10 | |
US289828P | 2001-05-10 | ||
PCT/US2002/014966 WO2002089806A1 (fr) | 2001-05-10 | 2002-05-10 | Ligands de liaison avec les proteines de fixation de fk-506 heterobicycles |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1423119A1 EP1423119A1 (fr) | 2004-06-02 |
EP1423119A4 true EP1423119A4 (fr) | 2005-04-13 |
Family
ID=23113278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02731761A Withdrawn EP1423119A4 (fr) | 2001-05-10 | 2002-05-10 | Ligands de liaison avec les proteines de fixation de fk-506 heterobicycles |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1423119A4 (fr) |
JP (1) | JP2004532854A (fr) |
BR (1) | BR0210060A (fr) |
CA (1) | CA2446795A1 (fr) |
MX (1) | MXPA03010255A (fr) |
WO (1) | WO2002089806A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2008002234A (es) * | 2005-08-19 | 2008-03-27 | Elan Pharm Inc | Inhibidores de sulfonamida n-biciclico puenteados de gamma secretasa. |
EP2690102A1 (fr) * | 2012-07-24 | 2014-01-29 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Aza-amides bicycliques pour le traitement de troubles psychiatriques |
WO2015110271A1 (fr) * | 2014-01-24 | 2015-07-30 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Dérivés de diazabicyclo[4.3.1]décane pour le traitement de troubles psychiatriques |
EP2899192A1 (fr) * | 2014-01-24 | 2015-07-29 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Dérivés de diazabicyclo[4.3.1]décane pour le traitement de troubles psychiatriques |
MX2016016190A (es) * | 2014-08-27 | 2017-03-08 | Hoffmann La Roche | Derivados de pirazino[2,1-a]isoquinolina sustituida para el tratamiento de trastornos del sistema nervioso central. |
US10597378B2 (en) | 2017-09-08 | 2020-03-24 | National Health Research Institutes | Tetrahydroisoquinolines for use as MOR/NOP dual agonists |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001042245A1 (fr) * | 1999-12-08 | 2001-06-14 | Bristol-Myers Squibb Company | Diamides bicycliques neurotrophiques |
WO2002032901A2 (fr) * | 2000-10-19 | 2002-04-25 | Pfizer Products Inc. | Derives de piperazine pontes |
WO2002060894A2 (fr) * | 2001-01-30 | 2002-08-08 | Bristol-Myers Squibb Company | Lactames sulfonamide inhibiteurs de facteur xa |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3880927A (en) * | 1972-06-19 | 1975-04-29 | Lilly Co Eli | {62 -Phenyl-{62 ,{62 -difluoroethylamines |
HUP0200637A3 (en) * | 1998-07-17 | 2003-05-28 | Agouron Pharmaceuticals Inc La | Compounds, compositions, and their use for stimulating neuronal growth and elongation |
-
2002
- 2002-05-10 EP EP02731761A patent/EP1423119A4/fr not_active Withdrawn
- 2002-05-10 BR BR0210060-6A patent/BR0210060A/pt not_active IP Right Cessation
- 2002-05-10 CA CA002446795A patent/CA2446795A1/fr not_active Abandoned
- 2002-05-10 MX MXPA03010255A patent/MXPA03010255A/es unknown
- 2002-05-10 WO PCT/US2002/014966 patent/WO2002089806A1/fr active Application Filing
- 2002-05-10 JP JP2002586941A patent/JP2004532854A/ja not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001042245A1 (fr) * | 1999-12-08 | 2001-06-14 | Bristol-Myers Squibb Company | Diamides bicycliques neurotrophiques |
WO2002032901A2 (fr) * | 2000-10-19 | 2002-04-25 | Pfizer Products Inc. | Derives de piperazine pontes |
WO2002060894A2 (fr) * | 2001-01-30 | 2002-08-08 | Bristol-Myers Squibb Company | Lactames sulfonamide inhibiteurs de facteur xa |
Non-Patent Citations (2)
Title |
---|
GUO, C. ET AL: "A concise synthesis of AG5473/5507 utilizing N-acyliminium ion chemistry", TETRAHEDRON LETTERS, 41(28), 5307-5311 CODEN: TELEAY; ISSN: 0040-4039, 2000, XP004222061 * |
See also references of WO02089806A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2004532854A (ja) | 2004-10-28 |
CA2446795A1 (fr) | 2002-11-14 |
MXPA03010255A (es) | 2005-03-07 |
EP1423119A1 (fr) | 2004-06-02 |
BR0210060A (pt) | 2004-08-17 |
WO2002089806A1 (fr) | 2002-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20031210 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20050228 |
|
17Q | First examination report despatched |
Effective date: 20070307 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20070918 |