EP1417329A4 - Methods for generating antibiotic resistant microbes and novel antibiotics - Google Patents

Methods for generating antibiotic resistant microbes and novel antibiotics

Info

Publication number
EP1417329A4
EP1417329A4 EP01963754A EP01963754A EP1417329A4 EP 1417329 A4 EP1417329 A4 EP 1417329A4 EP 01963754 A EP01963754 A EP 01963754A EP 01963754 A EP01963754 A EP 01963754A EP 1417329 A4 EP1417329 A4 EP 1417329A4
Authority
EP
European Patent Office
Prior art keywords
methods
antibiotic resistant
novel antibiotics
resistant microbes
generating antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01963754A
Other languages
German (de)
French (fr)
Other versions
EP1417329A1 (en
Inventor
Nicholas C Nicolaides
Philip M Sass
Luigi Grasso
J Bradford Kline
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphotek Inc
Original Assignee
Morphotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphotek Inc filed Critical Morphotek Inc
Publication of EP1417329A1 publication Critical patent/EP1417329A1/en
Publication of EP1417329A4 publication Critical patent/EP1417329A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C12Q1/20—Testing for antimicrobial activity of a material using multifield media

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP01963754A 2001-07-25 2001-07-25 Methods for generating antibiotic resistant microbes and novel antibiotics Withdrawn EP1417329A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2001/023888 WO2003012130A1 (en) 2001-07-25 2001-07-25 Methods for generating antibiotic resistant microbes and novel antibiotics

Publications (2)

Publication Number Publication Date
EP1417329A1 EP1417329A1 (en) 2004-05-12
EP1417329A4 true EP1417329A4 (en) 2005-05-11

Family

ID=21742739

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01963754A Withdrawn EP1417329A4 (en) 2001-07-25 2001-07-25 Methods for generating antibiotic resistant microbes and novel antibiotics

Country Status (3)

Country Link
EP (1) EP1417329A4 (en)
CA (1) CA2455686A1 (en)
WO (1) WO2003012130A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1572971B1 (en) * 2002-11-15 2009-09-30 Morphotek Inc. Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
TWI778025B (en) * 2017-02-24 2022-09-21 碁米庫斯生物科技股份有限公司 Antibiotic testing and screening system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146894A (en) * 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
WO2002054856A1 (en) * 2001-01-15 2002-07-18 Morphotek Inc. Chemical inhibitors of mismatch repair

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY103919A (en) * 1988-03-30 1993-10-30 Kao Corp Mutant resistant to cell membrane synthesis inhibitor and process for preparing the same.
DE19717346C2 (en) * 1997-04-24 1999-05-20 Max Planck Gesellschaft DNA probes, methods and kit for identifying antibiotic resistant bacterial strains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146894A (en) * 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
WO2002054856A1 (en) * 2001-01-15 2002-07-18 Morphotek Inc. Chemical inhibitors of mismatch repair

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DRUMMOND ET AL.: "DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutS alpha /hMutS beta ratio and reduces the efficiency of base-base mismatch repair.", PROC. NATL. ACAD. SCI. USA, vol. 94, July 1997 (1997-07-01), pages 10144 - 10149, XP002320277 *
DRUMMOND J T ET AL: "CISPLATIN AND ADRIAMYCIN RESISTANCE ARE ASSOCIATED WITH MUTL-ALPHA AND MISMATCH REPAIR DEFICIENCY IN AN OVARIAN TUMOR CELL LINE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 33, 16 August 1996 (1996-08-16), pages 19645 - 19648, XP002939396, ISSN: 0021-9258 *
PETER KARRAN: "Mechanisms of tolerance to DNA damaging therapeutic drugs", CARCINOGENESIS, vol. 22, no. 12, December 2001 (2001-12-01), pages 1931 - 1937, XP002320360 *
See also references of WO03012130A1 *

Also Published As

Publication number Publication date
EP1417329A1 (en) 2004-05-12
CA2455686A1 (en) 2003-02-13
WO2003012130A1 (en) 2003-02-13

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Legal Events

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Effective date: 20060522