EP1408890A2 - Contoured spinal fusion implants - Google Patents

Contoured spinal fusion implants

Info

Publication number
EP1408890A2
EP1408890A2 EP02757921A EP02757921A EP1408890A2 EP 1408890 A2 EP1408890 A2 EP 1408890A2 EP 02757921 A EP02757921 A EP 02757921A EP 02757921 A EP02757921 A EP 02757921A EP 1408890 A2 EP1408890 A2 EP 1408890A2
Authority
EP
European Patent Office
Prior art keywords
implant
bone
vertebral bodies
opposite sides
leading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02757921A
Other languages
German (de)
English (en)
French (fr)
Inventor
Gary Karlin Michelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SDGI Holdings Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1408890A2 publication Critical patent/EP1408890A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/02—Prostheses implantable into the body
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A61F2002/30112—Rounded shapes, e.g. with rounded corners
    • A61F2002/30131—Rounded shapes, e.g. with rounded corners horseshoe- or crescent- or C-shaped or U-shaped
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    • A61F2002/30476—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism
    • A61F2002/30507—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism using a threaded locking member, e.g. a locking screw or a set screw
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    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30841—Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30904—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves serrated profile, i.e. saw-toothed
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30975—Designing or manufacturing processes made of two halves
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/448—Joints for the spine, e.g. vertebrae, spinal discs comprising multiple adjacent spinal implants within the same intervertebral space or within the same vertebra, e.g. comprising two adjacent spinal implants
    • A—HUMAN NECESSITIES
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    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
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    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A—HUMAN NECESSITIES
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    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
    • A—HUMAN NECESSITIES
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    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0041—J-shaped
    • A—HUMAN NECESSITIES
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    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
    • A—HUMAN NECESSITIES
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    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00131—Tantalum or Ta-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Definitions

  • the present invention relates generally to interbody spinal implants preferably adapted for placement into an implantation space created across the height of a disc space between two adjacent vertebral bodies for the purpose of correcting spinal disease at that interspace.
  • the implants are adapted such that fusion occurs at least in part through the implants.
  • the implant may be made cortical bone, a bone composite, or a material other than bone.
  • Implants for placement between adjacent vertebral bodies in the spine come in a variety of shapes and sizes and are made of a variety of materials.
  • Such implants for use in human spinal surgery include implants made of bone or selected inert materials, such as titanium, that have a structure designed to promote fusion of the adjacent vertebral bodies by allowing bone to grow through the implant to thereby fuse the adjacent vertebral bodies.
  • Implants made of bone and utilized in interbody spinal surgery are often formed from a portion of the diaphysis.
  • the diaphysis is the shaft of a major long bone between the epiphyses, the ends of the bone forming the joints.
  • a diaphyseal ring is formed by making two spaced apart cuts approximately perpendicular to the long axis of the diaphyseal portion of a major long bone with the medullary canal forming an opening through the ring.
  • Such rings are generally harvested from femurs for use in the lumbar spine.
  • Other bones from the arm or leg or other part of the human skeleton may be useful in various regions of the spine.
  • the cuts are generally spaced apart so as to form a ring of bone having a height corresponding to the restored disc space or slightly greater.
  • Diaphyseal ring bone grafts are placed into the spine within and across the height of the space previously occupied by a spinal disc between adjacent vertebral bodies to achieve interbody fusion of those vertebral bodies through the disc space.
  • the diaphyseal ring bone graft is incorporated into the bony fusion over time.
  • the surgeon typically prepares an opening at the site of the intended fusion by removing some or all of the disc material that exists between the adjacent vertebral bodies to be fused. Because the outermost layers of bone of the vertebral end plate are relatively inert to new bone growth, the surgeon must work on the end plate to remove at least the outermost cell layers of bone to gain access to the blood-rich, vascular bone tissue within the vertebral body. In this manner, the vertebrae are prepared in a way that encourages new bone to grow into or through an implant that is placed between the vertebral bodies.
  • Present methods of forming this space between adjacent vertebral bodies generally include the use of one or more of the following: hand held biting and grasping instruments known as rongeurs; drills and drill guides; rotating burrs driven by a motor; osteotomes and chisels, and a double wheel cutter or vertebral interspace preparation device.
  • the double wheel cutter or vertebral interspace preparation device as disclosed by Michelson in WO 99/63891 , incorporated herein by reference, is adapted for linear insertion, i.e., insertion along a single axis, and without the need to substantially move the device from side to side within the disc space along a second axis.
  • the device has at its working end an abrading element having a width generally corresponding to the width of the implant to be implanted.
  • Interbody spinal implants that are entirely or almost entirely made of cortical bone or a bone composite material offer the advantages of that material including an appropriate modulus of elasticity and strength for the prescribed use, the capacity to be bioactive, including being osteoconductive, osteoinductive, osteogenic, and to more generally provide a good substrate for the formation of new bone as fusion occurs.
  • an improved interbody spinal fusion implant made of bone, a bone composite material, or a material other than bone having a configuration that provides for an improved congruity of the implant to the vertebral bodies and improved implant stability.
  • an interbody spinal fusion implant made of cortical bone for insertion at least in part into an implantation space formed across the height of a disc space between adjacent vertebral bodies of a human spine.
  • the implant includes a leading end for insertion first into the disc space and a trailing end opposite the leading end.
  • the implant has a length from the leading end to the trailing end.
  • the leading end is configured in the shape of half a circle from side to side.
  • the implant also includes opposed upper and lower portions between the leading and trailing ends that are adapted to be placed within the disc space to contact and support the adjacent vertebral bodies.
  • the upper and lower portions are non-arcuate along at least a portion of the length of the implant.
  • the implant also includes opposite sides between the upper portion and lower portion, and between the leading and trailing ends. At least one of the opposite sides is at least in part straight along at least a portion of the length of the implant.
  • an interbody spinal fusion implant made of cortical bone for insertion at least in part into an implantation space formed across the height of a disc space between adjacent vertebral bodies of a human spine.
  • the implant includes a leading end for insertion first into the disc space and a trailing end opposite the leading end.
  • the implant has a length from the leading end to the trailing end.
  • the leading end is configured from side to side in the shape of approximately one half of a first circle.
  • the trailing end has a radius of curvature of a second circle from side to side.
  • the second circle has a radius greater than the radius of the first circle.
  • the implant also includes opposed upper and lower portions between the leading and trailing ends that are adapted to be placed within the disc space to contact and support the adjacent vertebral bodies.
  • the implant has a maximum width that is greater than one-half of the width of the adjacent vertebral bodies into which the implant is adapted to be inserted.
  • the implants mentioned above are preferably manufactured from a bone ring obtained from a major long bone of a human having a medullary canal.
  • the implant includes at least a portion of the medullary canal passing through the upper and lower portions to form a passage adapted to hold bone growth promoting material for permitting for the growth of bone from vertebral body to vertebral body through the passage.
  • the implants mentioned above may be manufactured from a bone composite material.
  • an artificial interbody spinal fusion implant made of a material other than bone is provided for insertion at least in part into an implantation space formed across the height of a disc space between adjacent vertebral bodies of a human spine.
  • the implant includes a leading end for insertion first into the disc space and a trailing end opposite the leading end.
  • the implant has a length from the leading end to the trailing end.
  • the leading end is configured in the shape of approximately one half of a circle from side to side.
  • the implant also includes opposed upper and lower portions between the leading and trailing ends that are adapted to be placed within the disc space to contact and support the adjacent vertebral bodies.
  • the upper and lower portions are non-arcuate along at least a portion of the length of the implant.
  • the upper and lower portions include at least one opening in communication with one another and adapted to hold bone growth promoting material for permitting for the growth of bone from vertebral body to vertebral body through the implant.
  • the implant also includes opposite sides between the upper portion and lower portion, and between the leading and trailing ends. At least one of the opposite sides is at least in part straight along at least a portion of the length of the implant.
  • an artificial interbody spinal fusion implant made of a material other than bone is provided for insertion at least in part into an implantation space formed across the height of a disc space between adjacent vertebral bodies of a human spine.
  • the implant includes a leading end for insertion first into the disc space and a trailing end opposite the leading end.
  • the implant has a length from the leading end to the trailing end.
  • the leading end is configured from side to side in the shape of approximately one half of a first circle.
  • the trailing end has a radius of curvature of a second circle from side to side.
  • the second circle has a radius greater than the radius of the first circle.
  • the implant also includes opposed upper and lower portions between the leading and trailing ends that are adapted to be placed within the disc space to contact and support the adjacent vertebral bodies.
  • the upper and lower portions include at least one opening in communication with one another and adapted to hold bone growth promoting material for permitting for the growth of bone from vertebral body to vertebral body through the implant.
  • the implant has a maximum width that is greater than one-half of the width of the adjacent vertebral bodies into which the implant is adapted to be inserted.
  • Fig. 1 is a top plan view of a vertebral body in the lumbar spine with an implantation space formed to receive a spinal implant having a radius of curvature at the leading end that is less than the radius of curvature of the trailing end of the anterior aspect of the vertebral body between the sides of the implantation space.
  • Fig. 2 is a side elevation view of two adjacent vertebral bodies in the lumbar spine with the implantation space of Fig. 1 formed across the height of the spinal disc and into the adjacent vertebral bodies.
  • Fig. 3 is a side perspective view of the implantation space of Fig. 1.
  • Fig. 4 is a top plan view of a vertebral body in the cervical spine with an implantation space formed to receive a spinal implant having a radius of curvature at the leading end that is less than the radius of curvature of the trailing end of the anterior aspect of the vertebral body.
  • Fig. 5 is a side elevation view of two adjacent vertebral bodies in the cervical spine with the implantation space of Fig. 4 formed across the height of the spinal disc and into the adjacent vertebral bodies.
  • Fig. 6 is a side perspective view of the implantation space of Fig. 4.
  • Fig. 7 is a top plan view of a vertebral body in the lumbar spine and a preferred embodiment of an implant in accordance with the present invention installed into the implantation space of Fig.1.
  • Fig. 8 is a side elevation view of two adjacent vertebral bodies with the implant of Fig. 7 installed into the implantation space of Fig. 1 formed across the height of the spinal disc and into the adjacent vertebral bodies.
  • Fig. 9 is a top plan view of the implant of Fig. 7.
  • Fig. 10 is a side elevation view of the implant of Fig. 7.
  • Fig. 11 is a leading end view of the implant of Fig. 7.
  • Fig. 12 is a trailing end view of the implant of Fig. 7.
  • Fig. 13 is a top plan view of a vertebral body in the lumbar spine and another preferred embodiment of an implant in accordance with the present invention installed into the implantation space of Fig.1.
  • Fig. 14 is a side elevation view of two adjacent vertebral bodies with the implant of Fig. 13 installed into the implantation space of Fig. 1 formed across the height of the spinal disc and into the adjacent vertebral bodies.
  • Fig. 15 is a top plan view of the implant of Fig. 13.
  • Fig. 16 is a side elevation view of the implant of Fig. 13.
  • Fig. 17 is a leading end view of the implant of Fig. 13.
  • Fig. 18 is a trailing end view of the implant of Fig. 13.
  • Fig. 19 is a top plan view of another preferred embodiment of an implant in accordance with the present invention for use in the implantation space of Fig. 4.
  • Fig. 20 is a top plan view of another preferred embodiment of an implant in accordance with the present invention for use in the implantation space of Fig. 4.
  • Fig. 21 is a rear perspective view of another preferred embodiment of an implant in accordance with another preferred embodiment of the present invention having two members that are preferably mirror images of one another.
  • Fig. 22 is a top plan view of one of the members of the implant of Fig. 21.
  • Fig. 23 is an interior side elevation view of one of the members of the implant of Fig. 21.
  • Fig. 24 is an exterior side elevation view of one of the members of the implant of Fig. 21.
  • Fig. 25 is a leading end view of one of the members of the implant of Fig. 21.
  • Fig. 26 is a trailing end view of one of the members of the implant of Fig. 21.
  • Fig. 27 is a rear perspective view of another preferred embodiment of an implant in accordance with another preferred embodiment of the present invention having two members that are preferably mirror images of one another.
  • Fig. 28 is a top plan view of one of the members of the implant of Fig. 27.
  • Fig. 29 is an interior side elevation view of one of the members of the implant of Fig. 27.
  • Fig. 30 is an exterior side elevation view of one of the members of the implant of Fig. 27.
  • Fig. 31 is a leading end view of one of the members of the implant of Fig. 27.
  • Fig. 32 is a trailing end view of one of the members of the implant of Fig. 27.
  • Fig. 33 is a top plan view of another preferred embodiment of an implant in accordance with the present invention and a second implant that is a mirror image thereof illustrated in dashed line, both implants being shown implanted from an anterior approach to the spine in a vertebral body illustrated in dashed line.
  • Fig. 34 is a top plan view of another preferred embodiment of an implant in accordance with the present invention and a second implant that is a mirror image thereof illustrated in dashed line, both implants being shown implanted from an anterior approach to the spine in a vertebral body illustrated in dashed line.
  • Fig. 35 is a top plan view of another preferred embodiment of an implant in accordance with the present invention and a second implant that is a mirror image thereof illustrated in dashed line, both implants being shown implanted from a posterior approach to the spine in a vertebral body illustrated in dashed line.
  • Fig. 36 is a top plan view of another preferred embodiment of an implant in accordance with the present invention with bone engaging screws.
  • Fig. 37 is a side elevation view of the implant of Fig. 36.
  • Fig. 38 is a leading end view of the implant of Fig. 36.
  • Fig. 39 is a trailing end view of the implant of Fig. 36 with the bone engaging screws and lock installed.
  • Fig. 40 is a trailing end view of the implant of Fig. 39 without the bone engaging screws and lock installed.
  • Fig. 41 is a partial cross sectional side view of a preferred embodiment of a bone screw lock in accordance with the present invention for use with the implant of Fig. 36.
  • Fig. 42 is a cross sectional side view of another preferred embodiment of a bone screw lock in accordance with the present invention.
  • Fig. 43 is a top plan view of another preferred embodiment of an implant in accordance with the present invention with bone engaging screws.
  • Fig. 44 is a side elevation view of the implant of Fig. 43.
  • Fig. 45 is a leading end view of the implant of Fig. 43.
  • Fig. 46 is a trailing end view of the implant of Fig. 43 with the bone engaging screws and lock installed.
  • Fig. 47 is a trailing end view of the implant of Fig. 46 without the bone engaging screws and lock installed.
  • Fig. 48 is a partial cross sectional side view of a preferred embodiment of a bone screw lock in accordance with the present invention for use with the implant of Fig. 43.
  • Fig. 49 is a cross sectional side view of another preferred embodiment of a bone screw lock in accordance with the present invention. DETAILED DESCRIPTION OF THE INVENTION
  • Figs. 1-3 show an implantation space 50 formed across the height of the space occupied by a spinal disc D and into vertebral bodies V in the lumbar spine.
  • Implantation space 50 is preferably formed with the apparatus and method disclosed by Michelson in U.S. Patent No. 6,083,228, and WO 99/63891 , the disclosures of which are both incorporated herein by reference.
  • the instruments and method are not the subject matter of this application. It is understood that the preparation of the implantation space shown therein are a preferred instrument and method of preparing the implantation spaces and that any method and instrumentation suitable for the purpose may be utilized to prepare the desired implantation space.
  • Implantation space 50 is preferably formed in the endplate region ER in the subchondral bone of the vertebral body V.
  • Implantation space 50 preferably is formed to have a leading edge 52 with a shape from side to side of approximately one-half of a first circle A.
  • the trailing portion 54 of implantation space 50 preferably includes at least a portion of the anterior aspect of the vertebral body having a radius of curvature of a second circle B from side to side.
  • the radius of circle A is less than the radius of circle B.
  • Implantation space 50 may further include side edges 56, 58.
  • Side edges 56, 58 preferably include at least a straight portion, may be parallel to one another along lines P and form a curved transition with leading edge 52.
  • Figs. 4-6 show an implantation space 60 formed across the height of the space occupied by a spinal disc D and into vertebral bodies V in the cervical spine.
  • Implantation space 60 preferably is formed to have a leading edge 62 with a shape from side to side of approximately one half of a first circle A.
  • the trailing portion of implantation space 60 preferably includes at least a portion of the anterior aspect of the vertebral body having a radius of curvature of a second circle C from side to side.
  • the radius of circle A is less than the radius of circle C.
  • Implantation space 60 preferably does not have straight side edges like implantation space 50 because the anterior to posterior depth of cervical vertebral bodies is less than the anterior to posterior depth of lumbar vertebral bodies.
  • the radius of circle C is smaller in the cervical spine than the radius of circle B in the lumbar spine.
  • Implant 100A is preferably manufactured from a bone ring obtained from a major long bone of a human.
  • Implant 100A has a leading end 102A for insertion first into the disc space between two adjacent vertebral bodies and a trailing end 104A opposite leading end 102A, and opposite sides 110A, 112A therebetween.
  • Leading end 102A is preferably configured to match the contour of leading edge 52 of implantation space 50 and trailing end 104A is preferably configured to conform to the contour of the anterior aspect of the vertebral body at trailing portion 54 of implantation space 50.
  • Sides 110A, 112A are generally planar and preferably correspond to the configuration of side edges 56, 58 of implantation space 50.
  • leading end 102A, trailing end 104A, and opposite sides 110A, 112A are machined to have various configurations.
  • Leading end 102A is preferably machined to have a shape of approximately half a first circle from side to side. Where the implantation space is prepared into the vertebral bodies to have a lip or ridge that is at least in part curved, leading end 102A may be adapted to abut at least that portion of the implantation space.
  • One or both of sides 110A, 112A may also be formed to be at least in part oriented generally parallel to the mid-longitudinal axis of implant 100A and/or to each other. Further, leading end 102A may be tapered to facilitate insertion of implant 100A between the two adjacent vertebral bodies.
  • Trailing end 104A preferably forms an arc of a second circle from side to side having a radius greater than the radius of the first circle associated with leading end 102A.
  • at least a portion of trailing end 104A is adapted to conform to at least a portion of the peripheral contour of the anterior aspect of the vertebral bodies adjacent the disc space into which the implant is adapted to be inserted, though the invention is not so limited.
  • Fig. 12 shows that implant 100A preferably has a driver opening 116A at trailing end 104A for cooperatively engaging an instrument for installing implant 100A into the implantation space.
  • Driver opening 116A is preferably configured for threaded engagement with an insertion instrument.
  • Figs. 8, 10, and 11 show at least a portion of upper and lower surfaces 106A, 108A in an angular relationship to each other from trailing end 104A to leading end 102A for allowing for angulation of the adjacent vertebral bodies relative to each other.
  • upper and lower surfaces 106A, 108A are non- arcuate in a direction along the mid-longitudinal axis of implant 100A.
  • Implant 100A preferably has a maximum height that is less than the maximum width of the implant.
  • upper and lower surfaces 106A, 108A preferably have a passage 114A passing therethrough between leading and trailing ends 102A, 104A, respectively, and opposite sides 110A, 112A.
  • Passage 114A is preferably adapted to hold bone growth promoting material to permit for the growth of bone from vertebral body to vertebral body through passage 114A.
  • upper and lower surfaces 106A, 108A may include at least one opening in communication with one another to permit for the growth of bone from vertebral body to vertebral body through implant 100A, though the invention is not so limited.
  • Upper and lower surfaces 106A, 108A may also be porous and may include a bone ingrowth surface.
  • the implants described herein may include a bone- engaging surface 118A such as knurling for example.
  • Bone engaging surface 118A is configured to engage the bone of the adjacent vertebral bodies to maintain implant 100A within the adjacent vertebral bodies after implantation.
  • Other preferred embodiments of bone-engaging surfaces may include the surfaces of the implant being roughened, ratcheted, splined, or may include at least one protrusion to penetrably engage the bone of the vertebral bodies.
  • the implants of the present invention may include the surface configuration taught by Michelson in U.S. Patent Application No. 09/457,228, entitled "Spinal Implant Surface Configuration," the disclosure of which is incorporated by reference herein.
  • Implant 100A is preferably, but need not be manufactured from a diaphyseal bone ring.
  • the diaphyseal bone ring is preferably obtained from a major long bone of the human skeleton.
  • the bone ring is formed by making two spaced apart cuts approximately perpendicular to the long axis of the diaphyseal portion of the major long bone with a portion of the medullary canal forming an opening through the ring.
  • Such rings are generally harvested from femurs for use in the lumbar spine.
  • Other bones from the arm or leg or other part of the human skeleton may be useful in various regions of the spine.
  • the cuts may be made into the long bone generally perpendicular to or at other angles transverse to the long axis of the diaphyseal bone to form the bone ring having upper and lower surfaces. Making the cuts at an angle to each other creates a bone ring with upper and lower surfaces that are angled relative to each other.
  • the angular relationship of the upper and lower surface of the bone ring when subsequently formed into an implant and implanted into the spine, position the adjacent vertebral bodies in angular relationship to each other to restore the natural curvature of the spine, such as lordosis for example.
  • the bone may be machined to form an implant having a selected shape suitable for the intended purpose.
  • tools which may be used to machine the implant include, but are not limited to, burrs, reamers, mills, saws, trephines, chisels, and the like.
  • the leading end may be shaped to be approximately half a circle from side to side.
  • the sides may be machined to be at least in part straight.
  • the trailing end may be machined to any desired shape suitable for the intended purpose and may preferably be shaped to conform to the anatomical contour of the adjacent vertebral bodies between which the implant is adapted to be inserted.
  • the medullary canal preferably forms a passage adapted to hold bone growth promoting materials and/or substances. Where it is appropriate, it may be desirable to preserve at least a portion of the natural curvature of the perimeter of the bone ring as part of the configuration of the implant shape.
  • Implant 100A preferably has a length greater than one-half the depth of the vertebral bodies adjacent the disc space into which the implant is adapted to be inserted as measured between the anterior and posterior aspects of the vertebral bodies. Implant 100A also preferably has a maximum width that is greater than one-half the width of the adjacent vertebral bodies into which the implant is adapted to be inserted.
  • the implant can be manufactured from a composite bone material which may include at least one of cortical bone fibers, bone filaments, bone particles, or bone dust, and a binding material which may or may not be bioactive and/or bioresorbable such as a plastic, ceramic, for example.
  • bioresorbable materials may include polygalactone. Once formed, the composite implant material may be machined or molded, into the desired shape.
  • Implant 100B preferably made of a material other than bone in accordance with a preferred embodiment of the present invention.
  • Implant 100B has a leading end 102B for insertion first into the disc space between two adjacent vertebral bodies and a trailing end 104B opposite leading end 102B, and opposite sides 110B, 112B therebetween.
  • Leading end 102B is preferably configured to match the contour of leading edge 52 of implantation space 50 and trailing end 104B is preferably configured to conform to the contour of the anterior aspect of the vertebral body at trailing portion 54 of implantation space 50.
  • Sides 110B, 1 2B are generally planar and preferably correspond to the configuration of side edges 56, 58 of implantation space 50.
  • leading end 102B, trailing end 104B, and opposite sides 110B, 112B may have various configurations.
  • Leading end 102B is preferably is in the shape of approximately half a first circle from side to side. Where the implantation space is prepared into the vertebral bodies to have a lip or ridge that is at least in part curved, leading end 102B may be adapted to abut at least that portion of the implantation space.
  • One or both of sides 110B, 112B may also be formed to be at least in part oriented generally parallel to the mid-longitudinal axis of implant 100B and/or to each other.
  • One or both of sides 110B, 112B may include at least one opening 119B to permit for the growth of bone therethrough and into implant 100B, though the invention is not so limited.
  • leading end 102B may be tapered to facilitate insertion of implant 100B between the two adjacent vertebral bodies.
  • Trailing end 104B preferably forms an arc of a second circle from side to side having a radius greater than the radius of the first circle associated with leading end 102B.
  • at least a portion of trailing end 104B is adapted to conform to at least a portion of the peripheral contour of the anterior aspect of the vertebral bodies adjacent the disc space into which the implant is adapted to be inserted, though the invention is not so limited.
  • Fig. 18 shows that implant 100B preferably has a driver opening 116B at trailing end 104B for cooperatively engaging an instrument for installing implant 100 into the implantation space.
  • Driver opening 116B is preferably configured for threaded engagement with an insertion instrument.
  • Figs. 14, 16, and 17 show at least a portion of upper and lower surfaces 106B, 108B in an angular relationship to each other from trailing end 104B to leading end 102B for allowing for angulation of the adjacent vertebral bodies relative to each other.
  • upper and lower surfaces 106B, 108B are non- arcuate in a direction along the mid-longitudinal axis of implant 100B.
  • Implant 100B preferably has a maximum height that is less than the maximum width of the implant.
  • upper and lower surfaces 106B, 108B preferably have at least one opening 114B passing therethrough between leading and trailing ends 102B, 104B, respectively, and opposite sides 11 OB, 112B. Openings 114 are preferably adapted to hold bone growth promoting material to permit for the growth of bone from vertebral body to vertebral body through openings 114B and through implant 100B. Upper and lower surfaces 106B, 108B may also be porous and may include a bone ingrowth surface.
  • the implants described herein may include a bone- engaging surface 118B such as knurling for example.
  • Bone engaging surface 118B is configured to engage the bone of the adjacent vertebral bodies to maintain implant 100B within the adjacent vertebral bodies after implantation.
  • Other preferred embodiments of bone-engaging surfaces may include the surfaces of the implant being roughened, ratcheted, splined, or may include at least one protrusion to penetrably engage the bone of the vertebral bodies.
  • the base material used to form the implant of Figs. 13-18 is preferably a material other than bone.
  • the material of the implant may be formed of an artificial material such as metal including, but not limited to, titanium and its alloys, ASTM material, cobalt chrome, or tantalum, ceramic, various surgical grade plastics, plastic composites, carbon fiber composites, coral, and can include artificial materials which are at least in part bioresorbable.
  • Implant 100B preferably has a length greater than one-half the depth of the vertebral bodies adjacent the disc space into which the implant is adapted to be inserted as measured between the anterior and posterior aspects of the vertebral bodies.
  • Implant 100B also preferably has a maximum width that is greater than one-half the width of the adjacent vertebral bodies into which the implant is adapted to be inserted.
  • Fig. 19 shows another preferred embodiment of the present invention of an implant made of bone or a bone composite for use in the cervical spine generally referred to by the numeral 200A.
  • Implant 200A is preferably configured to conform to the shape of implantation space 60 formed in the endplates of adjacent cervical vertebral bodies with instrumentation and methods similar to those used in association with the lumbar spine but modified for use in the cervical spine.
  • Implant 200A may, for example, have a leading end 202A formed to have a shape of approximately one-half a first circle from side to side.
  • Trailing end 204A preferably may be formed as an arc of a second circle from side to side that intersects the curvature of leading end 202A from side to side.
  • the radius of the second circle associated with trailing end 204A is preferably greater that the radius of the first circle associated with leading end 202A.
  • Fig. 20 shows another preferred embodiment of the present invention of an implant made of a material other than bone for use in the cervical spine generally referred to by the numeral 200B.
  • Implant 200B is preferably configured to conform to the shape of implantation space 60 formed in the endplates of adjacent cervical vertebral bodies.
  • Implant 200B may, for example, have a leading end 202B formed to have a shape of approximately one-half a first circle from side to side.
  • Trailing end 204B preferably may be formed as an arc of a second circle from side to side that intersects the curvature of leading end 202B from side to side.
  • the radius of the second circle associated with trailing end 204B is preferably greater that the radius of the first circle associated with leading end 202B.
  • Figs. 21-26 show an implant 300A preferably made of bone or a bone composite material in accordance with another preferred embodiment of the present invention adapted for use from the anterior approach to the spine.
  • Fig. 21 shows a rear perspective view of implant 300A.
  • Implant 300A includes at least two members 300A', 300A" that are adapted to be placed side by side with one another.
  • Member 300A' is preferably, but need not be a mirror image of member 300A". The description of member 300A' is equally applicable to member 300A".
  • Member 300A' has a leading portion 302A' for insertion first into the disc space between two adjacent vertebral bodies and a trailing portion 304A' opposite leading portion 302A'.
  • Member 300A' has a top 306A', a bottom 308A', an interior side 310A', and an exterior facing side 312A' opposite interior facing side 310A'.
  • interior side describes the side of the member adapted to be orientated toward the interior side of another member when a pair of members are inserted side by side into the disc space.
  • interior side 310A' includes at least a portion of the medullary canal of the bone ring.
  • Leading end 302A of implant 300A is preferably configured in the shape of one-half a first circle from side to side.
  • Trailing end 304A, composed of trailing portions 304A', 304A" when members 300A', 300A" are placed side by side to one another, may, but need not be formed as an arc of a second circle side to side having a radius greater than a radius of the first circle associated with leading end 302A of implant 300A.
  • Member 300A' is placed side by side with member 300A" so that the portion of the medullary canal of interior side 310A' of each member are adjacent one another to form a passage 314A through implant 300A.
  • passage 314A is adapted to hold bone growth promoting material to permit for the growth of bone from vertebral body to vertebral body through passage 314A.
  • Member 300A' preferably has a maximum width W that is less than approximately one-half the width of the adjacent vertebral bodies into which the member is adapted to be inserted. Also, the combined width of both members 300A', 300A" is preferably greater than one-half the width of the adjacent vertebral bodies into which the members are adapted to be inserted.
  • Members 300A', 300A" provide the added advantage in that each member can be inserted through a smaller space than a single larger implant, to achieve the same effect as the larger implant.
  • Figs. 27-32 show an implant 300B made of a material other than bone in accordance with another preferred embodiment of the present invention adapted for use from the anterior approach to the spine.
  • Fig. 27 shows a rear perspective view of implant 300B.
  • Implant 300B includes at least two members 300B', 300B" that are adapted to be placed side by side with one another.
  • Member 300B' is preferably, but need not be a mirror image of member 300B". The description of member 300B' is equally applicable to member 300B".
  • Member 300B' has a leading portion 302B' for insertion first into the disc space between two adjacent vertebral bodies and a trailing portion 304B' opposite leading portion 302B'.
  • Member 300B' has a top 306B', a bottom 308B', an interior side 31 OB', and an exterior facing side 312B' opposite interior facing side 31 OB'.
  • Leading end 302B of implant 300B is preferably configured in the shape of one-half a first circle from side to side.
  • Trailing end 304B, composed of trailing portions 304B', 304B" when members 300B', 300B" are placed side by side to one another, may, but need not be formed as an arc of a second circle side to side having a radius greater than a radius of the first circle associated with leading end 302B of implant 300B.
  • Member 300' is placed side by side with member 300B" so that a portion of interior side 31 OB' of each member are adjacent one another.
  • Top 306B' and bottom 308B' preferably have at least one opening 314B' passing therethrough between leading and trailing portions 302B', 304B', respectively, and sides 31 OB', 312B'. Openings 314B' are adapted to hold bone growth promoting material to permit for the growth of bone from vertebral body to vertebral body through openings 314B.
  • Interior side 310B' may also include at least one opening 314B' passing therethrough configured to permit bone growth between and into adjacent members 300B', 300B".
  • Member 300B' preferably has a maximum width W that is less than approximately one-half the width of the adjacent vertebral bodies into which the member is adapted to be inserted. Also, the combined width of both members 300B', 300B" is preferably greater than one- half the width of the adjacent vertebral bodies into which the members are adapted to be inserted.
  • FIG. 33 shows an implant 400A in accordance with another preferred embodiment of the present invention adapted for use from an anterior approach to the spine.
  • Implant 400A is similar to implant 100A and has a leading end 402A that is shaped as approximately one-half a first circle.
  • Implant 400A is adapted to have a maximum width between sides 410A, 412A that is less than one-half of the width of the adjacent vertebral bodies into which implant 400A is adapted to be inserted.
  • Trailing end 404A forms an arc of a second circle having a radius that is substantially greater than the radius of the first circle associated with leading end 402A.
  • Implants 400A can be made of bone, a bone composite, or a material other than bone.
  • Fig. 34 shows an implant 500A in accordance with another preferred embodiment of the present invention adapted for use from an anterior approach to the spine.
  • Implant 500A is similar to implant 400A except that both leading end 502A and trailing end 504A are preferably in the shape of a half circle side to side.
  • Implants 500A can be made of bone, a bone composite, or a material other than bone.
  • Fig. 35 shows an implant 600A in accordance with another preferred embodiment of the present invention adapted for use from a posterior approach to the spine.
  • Implant 600A is similar to implant 400A except that trailing end 604A is preferably at least in part straight from side to side.
  • Implants 600A can be made of bone, a bone composite, or a material other than bone.
  • Implant 700A is similar to implant 100A and has a leading end 702A in the shape of approximately one-half a first circle A and a trailing end 704A formed as an arc of a second circle C.
  • Implant 700A preferably includes straight portions 711A, 713A along at least a portion of sides 710A, 712A, respectively, that are preferably parallel to each other along lines P.
  • Implant 700A also preferably includes a curved transition from each straight portion 711A, 713A of sides 710A, 712A, respectively, to trailing end 704A to form rounded portions 715A, 717A, respectively.
  • Rounded portion 715A, 717A may be an arc of a third circle E that preferably has a radius less than the radii of circle A associated with leading end 702A and/or circle C associated with trailing end 704A.
  • implant 700A may be machined so as to be adapted to receive through bone screw receiving holes 720A at trailing end 704A at least a pair of opposed appropriately sized bone screws 722A preferably, but not necessarily, made of cortical bone. Bone engaging screws 722A may be aligned or offset from each other. At least one screw 722A engages each of the vertebral bodies adjacent a disc space to be fused and into which implant 700A is implanted.
  • a purpose of the bone screws is to rigidly secure the implant within the vertebral segment.
  • a further purpose is to pull each of the adjacent vertebral bodies toward the implant and towards each other.
  • Trailing end 704A of implant 700A preferably includes a recess 724A having bone screw receiving holes 720A therein and an opening 726A configured to cooperatively receive a locking cap 728A adapted to lock at least one bone screw 722A to implant 700A.
  • implant 700A is preferably further machined and adapted to receive a lock 728A, preferably made of cortical bone, at trailing end 704A for securing bone engaging screws 722A therein and preventing the screws from backing out.
  • Locking cap 728A has a top 730A, a stem 732A, and a tool engagement area 734A. In use, locking cap cooperatively engages trailing end 704A of implant 700A at opening 726A to lock at least one bone screw to implant 700A.
  • locking cap 728A may include a thread on stem 732A to allow locking cap 728A to rotationally engage implant 700A.
  • Fig. 42 shows another preferred embodiment of a locking cap, generally referred to by the numeral 736A.
  • Locking cap 736A includes a top 738A having a thread 740A at its outer perimeter that is adapted to cooperatively engage a corresponding threaded recess in the implant.
  • the bone implant, bone screws, and/or locks can be made of a bioresorbable material, including but not limited to cortical bone, plastics and composite plastics.
  • Suitable plastics may include those comprising lactides, galactides, glycolide, capronlactone, trimethylene carbonate, or dioxanone in various polymers, and/or combinations thereof.
  • Implant 700B is similar to implant 100B and has a leading end 702B in the shape of approximately one-half a first circle A and a trailing end 704B formed as an arc of a second circle C.
  • Implant 700B preferably includes straight portions 711 B, 713B along at least a portion of sides 71 OB, 712B, respectively, that are preferably parallel to each other along lines P.
  • Implant 700B also preferably includes a curved transition from each straight portion 711 B, 713B of sides 71 OB, 712B, respectively, to trailing end 704B to form rounded portions 715B, 717B, respectively.
  • Rounded portion 715B, 717B may be an arc of a third circle E that preferably has a radius less than the radii of circle A associated with leading end 702B and/or circle C associated with trailing end 704B.
  • implant 700B may be adapted to receive through bone screw receiving holes 720B at trailing end 704B at least a pair of opposed appropriately sized bone screws 722B.
  • Bone engaging screws 722B may be aligned or offset from each other.
  • At least one screw 722B engages each of the vertebral bodies adjacent a disc space to be fused and into which implant 700B is implanted.
  • Trailing end 704B of implant 700B preferably includes a recess 724B having bone screw receiving holes 720B therein and an opening 726B configured to cooperatively receive a locking cap 728B adapted to lock at least one bone screw 722B to implant 700B.
  • implant 700B is preferably adapted to receive a lock 728B at trailing end 704B for securing bone engaging screws 722B therein and preventing the screws from backing out.
  • Locking cap 728B has a top 730B, a stem 732B, and a tool engagement area 734B. In use, locking cap cooperatively engages trailing end 704B of implant 700B at opening 726B to lock at least one bone screw to implant 700B.
  • locking cap 728B may include a thread on stem 732B to allow locking cap 728B to rotationally engage implant 700B.
  • Fig. 49 shows another preferred embodiment of a locking cap, generally referred to by the numeral 736B.
  • Locking cap 736B includes a top 738B having a thread 740B at its outer perimeter that is adapted to cooperatively engage a corresponding threaded recess in the implant.
  • Implant 700B, bone screws 722B, and/or locks 728B, 736B can be made of a bioresorbable material, including but not limited to plastics and composite plastics. Suitable plastics may include those comprising lactides, galactides, glycolide, capronlactone, trimethylene carbonate, or dioxanone in various polymers, and/or combinations thereof.
  • the implants of the present invention may have a depth of approximately, 28-36 mm, a width of approximately, 30-38 mm, and a height (max) of approximately 8-20 mm.
  • the radius of curvature of the leading end may be approximately 15-19 mm and the radius of curvature of the trailing end may be approximately 20-30 mm.
  • the implant may include, be made of, treated, coated, filled, used in combination with, or have an opening, a hollow, or a passage for containing artificial or naturally occurring materials and/or substances suitable for implantation in the human spine.
  • materials and/or substances include any source of osteogenesis, bone growth promoting materials, bone, bone derived substances or products, demineralized bone matrix, mineralizing proteins, ossifying proteins, bone morphogenetic proteins, hydroxyapatite, genes coding for the production of bone, and bone including, but not limited to, cortical bone.
  • the implant can include at least in part of materials that are bioabsorbable and/or resorbable in the body such as bone and/or bone growth promoting materials.
  • the implant of the present invention can be formed of a porous material or can be formed of a material that intrinsically participates in the growth of bone from one of adjacent vertebral bodies to the other of adjacent vertebral bodies. Where such implants are for posterior implantation, the trailing ends of such implants may be treated with, coated with, or used in combination with chemical substances to inhibit scar tissue formation in the spinal canal.
  • the implant of the present invention may be modified, or used in combination with materials to make it antibacterial, such as, but not limited to, electroplating or plasma spraying with silver ions or other substance. At least a portion of the implant may be treated to promote bone ingrowth between the implant and the adjacent vertebral bodies.
  • the implant of the present invention may be used in combination with a spinal fixation implant such as any object, regardless of material, that can be inserted into any portion of the spine, such as but not limited to interbody spinal implants, structural bone grafts, mesh, cages, spacers, staples, bone screws, plates, rods, tethers of synthetic cords or wires, or other spinal fixation hardware
  • a spinal fixation implant such as any object, regardless of material, that can be inserted into any portion of the spine, such as but not limited to interbody spinal implants, structural bone grafts, mesh, cages, spacers, staples, bone screws, plates, rods, tethers of synthetic cords or wires, or other spinal fixation hardware

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CA2443442A1 (en) 2002-10-10
AU2002338239B2 (en) 2005-12-22
JP4141259B2 (ja) 2008-08-27
WO2002078514A2 (en) 2002-10-10
JP2004526506A (ja) 2004-09-02
WO2002078514A3 (en) 2004-02-12

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