EP1389233A4 - Anticorps monoclonaux a ligands anti-rank convenant au traitement de troubles induits par des ligands rank - Google Patents
Anticorps monoclonaux a ligands anti-rank convenant au traitement de troubles induits par des ligands rankInfo
- Publication number
- EP1389233A4 EP1389233A4 EP02736659A EP02736659A EP1389233A4 EP 1389233 A4 EP1389233 A4 EP 1389233A4 EP 02736659 A EP02736659 A EP 02736659A EP 02736659 A EP02736659 A EP 02736659A EP 1389233 A4 EP1389233 A4 EP 1389233A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- rank ligand
- treatment
- monoclonal antibodies
- mediated disorders
- antibodies useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29203101P | 2001-05-18 | 2001-05-18 | |
US292031P | 2001-05-18 | ||
PCT/US2002/014246 WO2002095012A1 (fr) | 2001-05-18 | 2002-05-03 | Anticorps monoclonaux a ligands anti-rank convenant au traitement de troubles induits par des ligands rank |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1389233A1 EP1389233A1 (fr) | 2004-02-18 |
EP1389233A4 true EP1389233A4 (fr) | 2006-03-08 |
Family
ID=23122878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02736659A Withdrawn EP1389233A4 (fr) | 2001-05-18 | 2002-05-03 | Anticorps monoclonaux a ligands anti-rank convenant au traitement de troubles induits par des ligands rank |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1389233A4 (fr) |
JP (1) | JP2005515752A (fr) |
WO (1) | WO2002095012A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001293030B2 (en) | 2000-09-22 | 2007-07-19 | Immunex Corporation | Screening assays for agonists or antagonists of receptor activat or of NF-kB |
US8765388B2 (en) | 2007-08-10 | 2014-07-01 | Agency For Science, Technology And Research (A*Star) | VHZ for diagnosis and treatment of cancer |
US9580513B2 (en) | 2008-08-08 | 2017-02-28 | Agency For Science, Technology And Research (A*Star) | VHZ for diagnosis and treatment of cancers |
CN102741286B (zh) * | 2010-03-26 | 2013-12-25 | 刘庆法 | 以pae技术开发的抗人rankl单抗及其应用 |
EP2692359B1 (fr) * | 2011-03-31 | 2017-06-07 | Oriental Yeast Co., Ltd. | Potentialisateur d'immunité anticancéreuse contenant un antagoniste de rankl |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001091793A1 (fr) * | 2000-05-26 | 2001-12-06 | Smithkline Beecham Corporation | Anticorps monoclonaux contre le ligand rank, utilises pour le traitement d'etats pathologiques lies au ligand rank |
WO2002015846A2 (fr) * | 2000-08-21 | 2002-02-28 | Smithkline Beecham Corporation | Anticorps monoclonaux à ligands anti-rank convenant au traitement de troubles à médiation des ligands des rank |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6392019B1 (en) * | 1997-11-22 | 2002-05-21 | John Ford | Antibodies specific for EGF motif proteins |
-
2002
- 2002-05-03 WO PCT/US2002/014246 patent/WO2002095012A1/fr not_active Application Discontinuation
- 2002-05-03 EP EP02736659A patent/EP1389233A4/fr not_active Withdrawn
- 2002-05-03 JP JP2002592475A patent/JP2005515752A/ja not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001091793A1 (fr) * | 2000-05-26 | 2001-12-06 | Smithkline Beecham Corporation | Anticorps monoclonaux contre le ligand rank, utilises pour le traitement d'etats pathologiques lies au ligand rank |
WO2002015846A2 (fr) * | 2000-08-21 | 2002-02-28 | Smithkline Beecham Corporation | Anticorps monoclonaux à ligands anti-rank convenant au traitement de troubles à médiation des ligands des rank |
Non-Patent Citations (4)
Title |
---|
MENAA C ET AL: "Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 105, no. 12, June 2000 (2000-06-01), pages 1833 - 1838, XP002278692, ISSN: 0021-9738 * |
NAGAI MASAZUMI ET AL: "Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 269, no. 2, 16 March 2000 (2000-03-16), pages 532 - 536, XP002278694, ISSN: 0006-291X * |
See also references of WO02095012A1 * |
TANAKA Y ET AL: "INTERCELLULAR ADHESION MOLECULE 1 DISCRIMINATES FUNCTIONALLY DIFFERENT POPULATIONS OF HUMAN OSTEOBLASTS: CHARACTERISTIC INVOLVEMENT OF CELL CYCLE REGULATORS", JOURNAL OF BONE AND MINERAL RESEARCH, NEW YORK, NY, US, vol. 15, no. 10, October 2000 (2000-10-01), pages 1912 - 1923, XP009030306, ISSN: 0884-0431 * |
Also Published As
Publication number | Publication date |
---|---|
JP2005515752A (ja) | 2005-06-02 |
WO2002095012A1 (fr) | 2002-11-28 |
EP1389233A1 (fr) | 2004-02-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20031120 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: SMITHKLINE BEECHAM PLC Owner name: SMITHKLINE BEECHAM CORPORATION |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060120 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/68 20060101ALI20060116BHEP Ipc: C07K 16/28 20060101ALI20060116BHEP Ipc: C07H 21/04 20060101ALI20060116BHEP Ipc: C07K 16/00 20060101ALI20060116BHEP Ipc: G01N 33/53 20060101ALI20060116BHEP Ipc: C12N 5/06 20060101AFI20021130BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060419 |