EP1370252A4 - Thrombopoietin mimetics - Google Patents
Thrombopoietin mimeticsInfo
- Publication number
- EP1370252A4 EP1370252A4 EP02728383A EP02728383A EP1370252A4 EP 1370252 A4 EP1370252 A4 EP 1370252A4 EP 02728383 A EP02728383 A EP 02728383A EP 02728383 A EP02728383 A EP 02728383A EP 1370252 A4 EP1370252 A4 EP 1370252A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- thrombopoietin mimetics
- thrombopoietin
- mimetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26995801P | 2001-03-01 | 2001-03-01 | |
US269958P | 2001-03-01 | ||
PCT/US2002/006259 WO2002085343A1 (en) | 2001-03-01 | 2002-03-01 | Thrombopoietin mimetics |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1370252A1 EP1370252A1 (en) | 2003-12-17 |
EP1370252A4 true EP1370252A4 (en) | 2006-04-05 |
Family
ID=23029313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02728383A Withdrawn EP1370252A4 (en) | 2001-03-01 | 2002-03-01 | Thrombopoietin mimetics |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1370252A4 (en) |
WO (1) | WO2002085343A1 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CY2010012I2 (en) | 2000-05-25 | 2020-05-29 | Novartis Ag | THROMBOPOIETIN MIMETICS |
MY142390A (en) | 2002-05-22 | 2010-11-30 | Glaxosmithkline Llc | 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
AU2003255030A1 (en) | 2002-08-14 | 2004-03-03 | Nissan Chemical Industries, Ltd. | Thrombopoetin receptor activator and process for producing the same |
TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
EP1622609A4 (en) * | 2003-04-29 | 2008-09-03 | Smithkline Beecham Corp | Methods for treating degenerative diseases/injuries |
UA82695C2 (en) | 2003-06-06 | 2008-05-12 | Нисан Кемикал Индастриз, Лтд. | Heteroaromatic compounds as thrombopoietin receptor activators |
CN100443472C (en) * | 2003-06-06 | 2008-12-17 | 日产化学工业株式会社 | 3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators |
TW200526638A (en) | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
TWI351954B (en) | 2004-12-08 | 2011-11-11 | Nissan Chemical Ind Ltd | Heterocyclic compounds and thrombopoietin receptor |
CA2590204C (en) | 2004-12-14 | 2012-12-04 | Nissan Chemical Industries, Ltd. | Amide compounds and thrombopoietin receptor activators |
JP5071375B2 (en) | 2005-07-15 | 2012-11-14 | 日産化学工業株式会社 | Thiophene compound and thrombopoietin receptor activator |
JP5104752B2 (en) | 2005-07-20 | 2012-12-19 | 日産化学工業株式会社 | Pyrazole compound and thrombopoietin receptor activator |
EP1947101A4 (en) | 2005-11-07 | 2009-09-16 | Nissan Chemical Ind Ltd | Hydrazide compound and thrombopoietin receptor activator |
WO2007062078A2 (en) * | 2005-11-23 | 2007-05-31 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
JP5157900B2 (en) | 2006-06-07 | 2013-03-06 | 日産化学工業株式会社 | Nitrogen-containing heterocyclic compounds and thrombopoietin receptor activators |
ECSP077628A (en) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | NEW PHARMACEUTICAL COMPOSITION |
PE20100362A1 (en) | 2008-10-30 | 2010-05-27 | Irm Llc | PURINE DERIVATIVES THAT EXPAND HEMATOPOYETIC STEM CELLS |
CN102458120A (en) | 2009-05-29 | 2012-05-16 | 葛兰素史密斯克莱有限责任公司 | Methods of administration of thrombopoietin agonist compounds |
WO2011098095A1 (en) | 2010-02-09 | 2011-08-18 | Aplagen Gmbh | Peptides binding the tpo receptor |
UA109287C2 (en) * | 2010-11-02 | 2015-08-10 | ORGANIC AMIN SALTS OF THE AMINOBENSIC ACID DERIVATIVES AND THE METHOD OF PREPARATION thereof | |
WO2012102937A2 (en) | 2011-01-25 | 2012-08-02 | Irm Llc | Compounds that expand hematopoietic stem cells |
AU2012347534B2 (en) | 2011-12-08 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
DK2807165T3 (en) | 2012-01-27 | 2019-07-15 | Univ Montreal | PYRIMIDO [4,5-B] INDOL DERIVATIVES AND USE THEREOF IN EXPANSION OF HEMATOPOITIC STUDY CELLS |
CN104628647A (en) * | 2013-11-12 | 2015-05-20 | 上海医药工业研究院 | Preparation method of 3-methyl-1-(3,4-dimethylphenyl)-2-pyrazoline-5-one |
CA2946446C (en) | 2014-04-22 | 2020-11-03 | Universite De Montreal | Pyrido-pyrrolo-pyrimidine and pyrido-indole compounds, pharmaceutical compositions containing same and their use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells |
SG11201703407UA (en) | 2014-10-31 | 2017-05-30 | Nissan Chemical Ind Ltd | Ligand-binding fiber and cell culture substrate using said fiber |
CN110467531B (en) * | 2018-05-09 | 2022-04-19 | 新发药业有限公司 | Preparation method of 3 '-nitro-2' -hydroxybiphenyl-3-formic acid |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035446A1 (en) * | 1998-12-17 | 2000-06-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
WO2001017349A1 (en) * | 1999-09-10 | 2001-03-15 | Smithkline Beckman Corporation | Thrombopoietin mimetics |
WO2001089457A2 (en) * | 2000-05-25 | 2001-11-29 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
-
2002
- 2002-03-01 EP EP02728383A patent/EP1370252A4/en not_active Withdrawn
- 2002-03-01 WO PCT/US2002/006259 patent/WO2002085343A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035446A1 (en) * | 1998-12-17 | 2000-06-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
WO2001017349A1 (en) * | 1999-09-10 | 2001-03-15 | Smithkline Beckman Corporation | Thrombopoietin mimetics |
WO2001089457A2 (en) * | 2000-05-25 | 2001-11-29 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
Non-Patent Citations (2)
Title |
---|
EL LATIF, F. M. A.: "An improved synthesis of pyrazolo(3,4-b)(1,5) , benzoxazepine, -benzothiazepine and -benzodiazepine derivatives via a convenient one-pot synthesis.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 37, no. 6, 2000, US HETEROCORPORATION. PROVO., pages 1659 - 1662, XP002366337 * |
See also references of WO02085343A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002085343A1 (en) | 2002-10-31 |
EP1370252A1 (en) | 2003-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030925 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060222 |
|
17Q | First examination report despatched |
Effective date: 20061214 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: GLAXOSMITHKLINE LLC |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20100615 |