EP1368757A2 - Automatisation d'acquisition, d'analyse et de diffusion electronique de donnees experimentales - Google Patents

Automatisation d'acquisition, d'analyse et de diffusion electronique de donnees experimentales

Info

Publication number
EP1368757A2
EP1368757A2 EP01914604A EP01914604A EP1368757A2 EP 1368757 A2 EP1368757 A2 EP 1368757A2 EP 01914604 A EP01914604 A EP 01914604A EP 01914604 A EP01914604 A EP 01914604A EP 1368757 A2 EP1368757 A2 EP 1368757A2
Authority
EP
European Patent Office
Prior art keywords
data
submitting
request
delivery
person
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01914604A
Other languages
German (de)
English (en)
Inventor
Gary Kruppa, Ph.D.
Marshall Mayer Siegel
Nelson Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bruker Corp
Original Assignee
Bruker Daltonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bruker Daltonics Inc filed Critical Bruker Daltonics Inc
Publication of EP1368757A2 publication Critical patent/EP1368757A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D1/00—Measuring arrangements giving results other than momentary value of variable, of general application

Definitions

  • This invention relates generally to a method of automating the
  • This invention relates in general to a method of automating
  • mass spectrometers are instruments that are used to determine the
  • the masses of the resultant ions are determined in vacuum by a mass
  • Mass/charge analyzer that measures their mass/charge (m/z) ratio.
  • analyzers come in a variety of types, including magnetic field (B) ,
  • TOF time-of-flight
  • spectrometric method has a unique set of attributes .
  • ion cyclotron resonance spectrometers operate by
  • the packet of ions passes close to the receiver plates in the
  • ICR cell and induces image currents that can be amplified
  • the signal induced in the receiver plates depends on
  • the image currents induced in the receiver plates will contain
  • the device includes a sample delivery pump for
  • a reagent delivery pump for dispensing a precise amount of the
  • test liquid passes along
  • MacPhail U.S. Patent No. 5,089,956 relates to a method for
  • a user indicates to the system
  • the selected document is
  • Kitain et al U.S. Patent No. 5,864,871 is directed to an
  • An integral database stores research reports produced by
  • a delivery module allows a user to submit a
  • query results may be delivered via the Internet .
  • Kitain et al is directed largely towards the financial and
  • a request is placed by a user for a particular
  • a storage location may
  • the system delivers the data to the storage location.
  • the device converts status signals from the
  • the device can then convert the e-mail
  • Described herein is a system that interfaces with an analytical instrument, e.g., a mass
  • delivery system could take the form of the creation of a web page
  • instrumentation need not be of the
  • FIG. 1 depicts a flow diagram of the system in an FTICR MS
  • FIG. 2 is an example of an acquired spectrum of a mixture of
  • FIG. 3 is an example of experimental results that could be e-
  • the FTICR mass spectrometer 101 The FTICR mass spectrometer 101
  • Model 1100 HPLC system (Degasser, Pump, Diode Array Detector,
  • ESI source was used as an external trap to accumulate ions for
  • bradykinin substance P
  • gramacidin substance P
  • bombesin substance P
  • actinomycin D actinomycin D
  • the carrier solvent used was 1 : 1
  • chlorothiazide C7 H6 N3 04 S2 Cl, MW 294.9488
  • chloramphenicol Cll H12 N2 05 C12 , MW
  • a PC 114 was used to download sample information from a
  • Tcl/Tk (Tool command language/Toolkit) .
  • Tcl/Tk is a platform
  • the processing software could be controlled completely by the Tel script .
  • the Tel scripts can also obtain information f om
  • the system can be divided into two
  • the autosampler within the FTICR MS 101, upon injecting a 5
  • FTICR MS sends a TTL trigger 104 to the mass spectrometer 101 to
  • the sample typically flows into the ESI source, typically about 30 s.
  • the pretuned and precalibrated instrument acquires and sums 30
  • domain data 102 is stored for future processing. After a total
  • sample information is
  • the sample list 110 is transferred as a
  • the sample list 110 information (chemist name, notebook
  • domain spectra 102 are automatically processed by preset operating
  • the processes 108 are apodization of the time-domain data, generally selected as a centered sine bell function, fast
  • this module 109 On to data correlation and interpretation, this module 109
  • test results for all the samples is generated automatically for
  • alias file is set up to link submitter names with their e-mail
  • the Tcl/Tk macro calls up an e-mail macro which
  • FIG. 2 is an example of an automatically acquired spectrum of
  • Exemplary peaks 201, 202, 203 correspond to mass values on the mass/charge x-axis 204 and their high relative intensity on the y-
  • FIG. 3 illustrates a typical e-mailed exact-mass report using
  • Exemplary adduct values 301, 302, 303 correspond to peak

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

L'invention concerne un système assurant essentiellement l'interface avec des instruments de laboratoire pour l'acquisition de données expérimentales, puis pour le traitement de ces données dans un format approprié à la diffusion électronique et pour leur transmission aux sujets. Selon une variante, le système décrit fait l'acquisition automatique de données d'analyse ES-MS à haute résolution, en spectrométrie de masse ICR-FTMS. A l'injection de chaque échantillon, un autoéchantillonneur transmet un signal de fermeture de contact au spectromètre de masse pour lancer l'acquisition de données. Un progiciel est ensuite utilisé hors ligne pour l'acceptation d'une liste d'échantillons comportant des informations d'entrée associées aux différents échantillons. Pour chacun des échantillons, le logiciel traite et interprète automatiquement les données acquises. Enfin, le système imprime les spectres, les listes de crêtes, les rapports de masse exacts, et adresse par messagerie électronique les rapports de masse exacts aux sujets.
EP01914604A 2000-02-28 2001-02-28 Automatisation d'acquisition, d'analyse et de diffusion electronique de donnees experimentales Withdrawn EP1368757A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US514793 1990-04-26
US51479300A 2000-02-28 2000-02-28
PCT/US2001/006569 WO2001065401A2 (fr) 2000-02-28 2001-02-28 Automatisation d'acquisition, d'analyse et de diffusion electronique de donnees experimentales

Publications (1)

Publication Number Publication Date
EP1368757A2 true EP1368757A2 (fr) 2003-12-10

Family

ID=24048716

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01914604A Withdrawn EP1368757A2 (fr) 2000-02-28 2001-02-28 Automatisation d'acquisition, d'analyse et de diffusion electronique de donnees experimentales

Country Status (2)

Country Link
EP (1) EP1368757A2 (fr)
WO (1) WO2001065401A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111078663A (zh) * 2019-11-26 2020-04-28 蔡竞慧 一种高效实验数据分析系统
CN112763432B (zh) * 2020-12-25 2023-04-28 中国科学院上海高等研究院 一种自动采集吸收谱实验数据的控制方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6216104B1 (en) * 1998-02-20 2001-04-10 Philips Electronics North America Corporation Computer-based patient record and message delivery system
US6470386B1 (en) * 1997-09-26 2002-10-22 Worldcom, Inc. Integrated proxy interface for web based telecommunications management tools

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996030767A1 (fr) * 1995-03-27 1996-10-03 Ngk Insulators, Ltd. Systeme d'analyse automatique
US5864871A (en) * 1996-06-04 1999-01-26 Multex Systems Information delivery system and method including on-line entitlements
JPH10132956A (ja) * 1996-10-30 1998-05-22 East Kurieiteibu:Kk 気象情報提供装置および方法
JPH10228311A (ja) * 1997-02-18 1998-08-25 Shimadzu Corp 機器故障の遠隔診断システム
US5923416A (en) * 1997-03-20 1999-07-13 Hartford Hospital Automated method and apparatus for evaluating the performance characteristics of endoscopes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6470386B1 (en) * 1997-09-26 2002-10-22 Worldcom, Inc. Integrated proxy interface for web based telecommunications management tools
US6216104B1 (en) * 1998-02-20 2001-04-10 Philips Electronics North America Corporation Computer-based patient record and message delivery system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0165401A3 *

Also Published As

Publication number Publication date
WO2001065401A2 (fr) 2001-09-07
WO2001065401A3 (fr) 2003-10-16

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