EP1365645A2 - Souris transgeniques contenant des disruptions geniques ciblees - Google Patents

Souris transgeniques contenant des disruptions geniques ciblees

Info

Publication number
EP1365645A2
EP1365645A2 EP01967934A EP01967934A EP1365645A2 EP 1365645 A2 EP1365645 A2 EP 1365645A2 EP 01967934 A EP01967934 A EP 01967934A EP 01967934 A EP01967934 A EP 01967934A EP 1365645 A2 EP1365645 A2 EP 1365645A2
Authority
EP
European Patent Office
Prior art keywords
gene
agent
disruption
cell
transgenic mouse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01967934A
Other languages
German (de)
English (en)
Inventor
Thomas J. Brennan
Michael W. Leviten
Robert Klein
William Matthews
Mark Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deltagen Inc
Original Assignee
Deltagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc filed Critical Deltagen Inc
Publication of EP1365645A2 publication Critical patent/EP1365645A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

La présente invention concerne des animaux transgéniques ainsi que des compositions et des méthodes relatives à la caractérisation de fonctions géniques. Spécifiquement, la présente invention concerne des souris transgéniques contenant des mutations dans le gène CIBLE. Ces souris transgéniques sont utiles en tant que cobaye pour des maladies et pour identifier des agents modulant l'expression génique et la fonction génique, et en tant que traitements potentiels contre divers états pathologiques et conditions pathologiques.
EP01967934A 2000-06-21 2001-06-21 Souris transgeniques contenant des disruptions geniques ciblees Withdrawn EP1365645A2 (fr)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US21320100P 2000-06-21 2000-06-21
US21402800P 2000-06-21 2000-06-21
US21367100P 2000-06-21 2000-06-21
US21367000P 2000-06-21 2000-06-21
US21319000P 2000-06-21 2000-06-21
US213190P 2000-06-21
US213670P 2000-06-21
US213201P 2000-06-21
US213671P 2000-06-21
US214028P 2000-06-21
US22312300P 2000-08-07 2000-08-07
US223123P 2000-08-07
US26604601P 2001-02-01 2001-02-01
US266046P 2001-02-01
US28070501P 2001-03-29 2001-03-29
US280705P 2001-03-29
US28270101P 2001-04-09 2001-04-09
US28266801P 2001-04-09 2001-04-09
US282701P 2001-04-09
US282668P 2001-04-09
PCT/US2001/020015 WO2001098508A2 (fr) 2000-06-21 2001-06-21 Souris transgeniques contenant des disruptions geniques ciblees

Publications (1)

Publication Number Publication Date
EP1365645A2 true EP1365645A2 (fr) 2003-12-03

Family

ID=27581158

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01967934A Withdrawn EP1365645A2 (fr) 2000-06-21 2001-06-21 Souris transgeniques contenant des disruptions geniques ciblees

Country Status (5)

Country Link
EP (1) EP1365645A2 (fr)
JP (1) JP2004517605A (fr)
AU (1) AU2001288214A1 (fr)
CA (1) CA2411978A1 (fr)
WO (1) WO2001098508A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001281933A1 (en) * 2000-06-30 2002-01-14 Ingenium Pharmaceuticals Ag Human g protein-coupled receptor igpcr17, and uses therof
US7416849B2 (en) * 2001-05-11 2008-08-26 Oscient Pharmaceuticals Corporation HBM variants that modulate bone mass and lipid levels
US7514594B2 (en) 2001-05-11 2009-04-07 Wyeth Transgenic animal model of bone mass modulation
JPWO2004074483A1 (ja) * 2003-02-20 2006-06-01 哲哉 野阪 Ｔｓｇ遺伝子ノックアウト動物
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
EP2878335B1 (fr) 2013-11-10 2018-01-03 Brainsgate Ltd. Implant et système d'implantation pour stimulateur neural
US10271907B2 (en) 2015-05-13 2019-04-30 Brainsgate Ltd. Implant and delivery system for neural stimulator

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0198508A2 *

Also Published As

Publication number Publication date
WO2001098508A2 (fr) 2001-12-27
CA2411978A1 (fr) 2001-12-27
WO2001098508A3 (fr) 2003-10-02
JP2004517605A (ja) 2004-06-17
AU2001288214A1 (en) 2002-01-02

Similar Documents

Publication Publication Date Title
WO2002046390A2 (fr) Souris transgeniques a disruptions geniques de tyrosine phosphatase rptpb
US20020169307A1 (en) Transgenic mice containing LPR5 gene disruptions
WO2002047477A2 (fr) Souris transgeniques presentant des disruptions geniques de la proteine interagissant avec l'huntingtine
EP1365645A2 (fr) Souris transgeniques contenant des disruptions geniques ciblees
US20060143724A1 (en) Transgenic mice containing anaphylatoxin C3a gene disruptions
WO2002006445A9 (fr) Souris transgenique contenant des disruptions geniques ciblees
US20030079243A1 (en) Transgenic mice containing TRP6 calcium ion channel gene disruptions
US20060253915A1 (en) Transgenic Mice Containing Kir3.3 Potassium Channel Gene Disruptions
US20030033624A1 (en) Transgenic mice containing adrenomedullin receptor gene disruptions
US20060143720A1 (en) Transgenic mice containing chordin gene disruptions
US20060156426A1 (en) Transgenic mice containing ABC transporter-like ATPase gene disruptions
US20030014769A1 (en) Transgenic mice containing GPCR-like transmembrane protein disruptions
US6717032B2 (en) Transgenic mice containing DEZ orphan receptor gene disruptions
US20020129397A1 (en) Transgenic mice containing brain-specific membrane-anchored protein gene disruptions
US20030023998A1 (en) Transgenic mice containing 5-HT-2B gene disruptions
US20020170075A1 (en) Transgenic mice comprising beta-1,3-N-acetyllactosamine disruptions
AU2001266936A1 (en) Transgenic mice containing nuclear hormone receptor gene disruptions
US20020177134A1 (en) Transgenic mice containing PAFR gene disruptions
US20020162131A1 (en) Transgenic mice containing cerberus gene disruptions
US20020088018A1 (en) Transgenic mice containing MAS orphan receptor gene disruptions
US20020184657A1 (en) Transgenic mice containing glucocorticoid-induced receptor gene disruptions
US20020194636A1 (en) Transgenic mice containing polycystin-related gene disruptions
US20060037094A1 (en) Secreted protein associated with depression, compositions and methods of use thereof
US20030023999A1 (en) Transgenic mice containing GNB1 gene disruptions
WO2002079426A2 (fr) Souris transgeniques contenant des disruptions geniques de l'hinibiteur de serine protease pai3

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030121

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20041231