EP1360191A4 - "verfahren und zusammensetzungen zur in-vivo-expression von polynukleotiden, spezifisch in glatten muskelzellen" - Google Patents

"verfahren und zusammensetzungen zur in-vivo-expression von polynukleotiden, spezifisch in glatten muskelzellen"

Info

Publication number
EP1360191A4
EP1360191A4 EP02704234A EP02704234A EP1360191A4 EP 1360191 A4 EP1360191 A4 EP 1360191A4 EP 02704234 A EP02704234 A EP 02704234A EP 02704234 A EP02704234 A EP 02704234A EP 1360191 A4 EP1360191 A4 EP 1360191A4
Authority
EP
European Patent Office
Prior art keywords
vivo
compositions
methods
smooth muscle
muscle cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02704234A
Other languages
English (en)
French (fr)
Other versions
EP1360191A2 (de
Inventor
Gary K Owens
Ichiro Manabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Setagon Inc
Original Assignee
Setagon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Setagon Inc filed Critical Setagon Inc
Publication of EP1360191A2 publication Critical patent/EP1360191A2/de
Publication of EP1360191A4 publication Critical patent/EP1360191A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP02704234A 2001-01-24 2002-01-24 "verfahren und zusammensetzungen zur in-vivo-expression von polynukleotiden, spezifisch in glatten muskelzellen" Withdrawn EP1360191A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26381101P 2001-01-24 2001-01-24
US263811P 2001-01-24
PCT/US2002/002016 WO2002059270A2 (en) 2001-01-24 2002-01-24 Methods and compositions for expressing polynucleotides specifically in smooth muscle cells in vivo

Publications (2)

Publication Number Publication Date
EP1360191A2 EP1360191A2 (de) 2003-11-12
EP1360191A4 true EP1360191A4 (de) 2004-08-25

Family

ID=23003314

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02704234A Withdrawn EP1360191A4 (de) 2001-01-24 2002-01-24 "verfahren und zusammensetzungen zur in-vivo-expression von polynukleotiden, spezifisch in glatten muskelzellen"

Country Status (4)

Country Link
EP (1) EP1360191A4 (de)
AU (1) AU2002237928A1 (de)
CA (1) CA2435631A1 (de)
WO (1) WO2002059270A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002306763A1 (en) * 2001-03-20 2002-10-03 University Of Virginian Patent Foundation Methods for identifying and purifying smooth muscle progenitor cells
CN102676527B (zh) * 2012-05-29 2013-09-25 山东农业大学 一种骨骼肌特异性MYHC-IIx启动子及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0807688A2 (de) * 1996-05-10 1997-11-19 Franz, Wolfgang-M., Dr. Nukleinsaürekonstrukt zur spezifischen Genexpression in glatten Gefässmuskelzellen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9305091D0 (en) * 1993-03-12 1993-04-28 Thrombosis Res Inst Eukaryotic expression vectors driven by a novel strong mammalian cell promoter
WO1999036101A1 (en) * 1998-01-16 1999-07-22 The University Of Virginia Patent Foundation Identification of a smooth muscle cell (smc) specific smooth muscle myosin heavy chain (sm-mhc) promoter/enhancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0807688A2 (de) * 1996-05-10 1997-11-19 Franz, Wolfgang-M., Dr. Nukleinsaürekonstrukt zur spezifischen Genexpression in glatten Gefässmuskelzellen

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
FRANZ WOLFGANG M ET AL: "The 2.3 kb smooth muscle myosin heavy chain promoter directs gene expression into the vascular system of transgenic mice and rabbits", CARDIOVASCULAR RESEARCH, vol. 43, no. 4, September 1999 (1999-09-01), pages 1040 - 1048, XP002286353, ISSN: 0008-6363 *
LI LI ET AL: "Evidence for serum response factor-mediated regulatory networks governing SM22-alpha transcription in smooth, skeletal, and cardiac muscle cells", DEVELOPMENTAL BIOLOGY, vol. 187, no. 2, 1997, pages 311 - 321, XP002286354, ISSN: 0012-1606 *
MADSEN C S ET AL: "EXPRESSION OF THE SMOOTH MUSCLE MYOSIN HEAVY CHAIN GENE IS REGULATED BY A NEGATIVE-ACTING GC-RICH ELEMENT LOCATED BETWEEN TWO POSITIVE-ACTING SERUM RESPONSE FACTOR-BINDING ELEMENTS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 10, 7 March 1997 (1997-03-07), pages 6332 - 6340, XP002918192, ISSN: 0021-9258 *
MADSEN C S ET AL: "SMOOTH MUSCLE-SPECIFIC EXPRESSION OF THE SMOOTH MUSCLE MYOSIN HEAVY CHAIN GENE IN TRANSGENIC MICE REQUIRES 5'-FLANKING AND FIRST INTRONIC DNA SEQUENCE", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 82, no. 8, 4 May 1998 (1998-05-04), pages 908 - 917, XP002918193, ISSN: 0009-7330 *
MANABE I ET AL: "Full transcriptional activity of the smooth muscle myosin heavy chain gene requires multiple CArG elements in the 5'flanking and first intronic sequence", FASEB JOURNAL, vol. 13, no. 4 PART 1, 12 March 1999 (1999-03-12), Annual Meeting of the Professional Research Scientists for Experimental Biology 99;Washington, D.C., USA; April 17-21, 1999, pages A437, XP001194405, ISSN: 0892-6638 *
MANABE ICHIRO ET AL: "CArG elements control smooth muscle subtype-specific expression of smooth muscle myosin in vivo", JOURNAL OF CLINICAL INVESTIGATION, vol. 107, no. 7, April 2001 (2001-04-01), pages 823 - 834, XP002286356, ISSN: 0021-9738 *
MANABE ICHIRO ET AL: "The smooth muscle myosin heavy chain gene exhibits smooth muscle subtype-selective modular regulation in vivo", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 42, 19 October 2001 (2001-10-19), pages 39076 - 39087, XP002286357, ISSN: 0021-9258 *
MERICSKAY MATHIAS ET AL: "An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cells", DEVELOPMENTAL BIOLOGY, vol. 226, no. 2, 15 October 2000 (2000-10-15), pages 192 - 208, XP002286355, ISSN: 0012-1606 *

Also Published As

Publication number Publication date
EP1360191A2 (de) 2003-11-12
WO2002059270A8 (en) 2003-11-06
CA2435631A1 (en) 2002-08-01
WO2002059270A2 (en) 2002-08-01
WO2002059270A3 (en) 2003-03-27
AU2002237928A1 (en) 2002-08-06

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Effective date: 20070806