EP1335708A4 - Controlled release metformin compositions - Google Patents

Controlled release metformin compositions

Info

Publication number
EP1335708A4
EP1335708A4 EP01991078A EP01991078A EP1335708A4 EP 1335708 A4 EP1335708 A4 EP 1335708A4 EP 01991078 A EP01991078 A EP 01991078A EP 01991078 A EP01991078 A EP 01991078A EP 1335708 A4 EP1335708 A4 EP 1335708A4
Authority
EP
European Patent Office
Prior art keywords
controlled release
release metformin
metformin compositions
compositions
controlled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01991078A
Other languages
German (de)
French (fr)
Other versions
EP1335708A1 (en
Inventor
Chen Chih-Ming
Cheng Xiu-Xiu
Steve Jan
Joseph Chou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Andrx Laboratories LLC
Original Assignee
Andrx Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/705,625 external-priority patent/US6790459B1/en
Priority claimed from US09/705,630 external-priority patent/US6866866B1/en
Application filed by Andrx Corp filed Critical Andrx Corp
Priority to EP06013969A priority Critical patent/EP1723948A1/en
Publication of EP1335708A1 publication Critical patent/EP1335708A1/en
Publication of EP1335708A4 publication Critical patent/EP1335708A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP01991078A 2000-11-03 2001-10-30 Controlled release metformin compositions Ceased EP1335708A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06013969A EP1723948A1 (en) 2000-11-03 2001-10-30 Controlled release compositions of biguanide with less side effects and treatment regimen thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US705625 1991-05-24
US09/705,625 US6790459B1 (en) 2000-11-03 2000-11-03 Methods for treating diabetes via administration of controlled release metformin
US09/705,630 US6866866B1 (en) 2000-11-03 2000-11-03 Controlled release metformin compositions
US705630 2000-11-03
PCT/US2001/048306 WO2002036100A1 (en) 2000-11-03 2001-10-30 Controlled release metformin compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP06013969A Division EP1723948A1 (en) 2000-11-03 2001-10-30 Controlled release compositions of biguanide with less side effects and treatment regimen thereof

Publications (2)

Publication Number Publication Date
EP1335708A1 EP1335708A1 (en) 2003-08-20
EP1335708A4 true EP1335708A4 (en) 2005-07-13

Family

ID=27107545

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06013969A Ceased EP1723948A1 (en) 2000-11-03 2001-10-30 Controlled release compositions of biguanide with less side effects and treatment regimen thereof
EP01991078A Ceased EP1335708A4 (en) 2000-11-03 2001-10-30 Controlled release metformin compositions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP06013969A Ceased EP1723948A1 (en) 2000-11-03 2001-10-30 Controlled release compositions of biguanide with less side effects and treatment regimen thereof

Country Status (9)

Country Link
EP (2) EP1723948A1 (en)
JP (1) JP2004531463A (en)
KR (1) KR20030061392A (en)
AU (1) AU2002230830A1 (en)
BR (1) BR0115390A (en)
CA (1) CA2427195C (en)
MX (1) MXPA03003994A (en)
NZ (1) NZ525559A (en)
WO (1) WO2002036100A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8323692B2 (en) * 2002-02-21 2012-12-04 Valeant International Bermuda Controlled release dosage forms
WO2003105809A1 (en) 2002-06-17 2003-12-24 Themis Laboratories Private Limited Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
EP1510208A1 (en) 2003-08-22 2005-03-02 Fournier Laboratories Ireland Limited Pharmaceutical composition comprising a combination of metformin and statin
CA2564750A1 (en) * 2004-04-29 2005-11-17 Andrx Labs, Llc Controlled release metformin compositions
JPWO2005117855A1 (en) * 2004-06-04 2008-04-03 興和株式会社 Drugs for the prevention or treatment of diabetes
CN101119748A (en) * 2004-12-13 2008-02-06 第一三共株式会社 Pharmaceutical composition for treatment of diabetes
PE20061245A1 (en) * 2005-03-30 2007-01-06 Generex Pharm Inc COMPOSITIONS FOR ORAL TRANSMUCOUS TRANSMISSION OF METFORMIN
KR100780553B1 (en) * 2005-08-18 2007-11-29 한올제약주식회사 Pharmaceutical compositions and formulations of Metformin extended release tablets and its preparing method
KR101362729B1 (en) 2007-05-08 2014-02-12 삼성디스플레이 주식회사 Optical sheet, method of manufacturing the same and display apparatus having the same
WO2010026467A2 (en) 2008-09-04 2010-03-11 Torrent Pharmaceuticals Ltd. Controlled release dosage form of high solubility active ingredient
KR101597004B1 (en) 2013-07-25 2016-02-23 씨제이헬스케어 주식회사 Pharmaceutical combination comprising sustained-release type metformin and immediate-release type HMG-CoA reductase inhibitor
CN106727407B (en) * 2017-01-04 2018-01-19 北京汇诚瑞祥医药技术有限公司 A kind of metformin controlled release preparation and preparation method thereof
KR20190036370A (en) 2017-09-27 2019-04-04 서원대학교산학협력단 Drug Delivery System for Sustained Release Formaulation of Drugs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012097A1 (en) * 1998-08-31 2000-03-09 Andrx Pharmaceuticals, Inc. Controlled release tablet comprising a hypoglycemic drug and an antihyperglycemic drug

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US411210A (en) 1889-09-17 Water-wheel
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
FR2243684B1 (en) 1973-09-19 1977-01-28 Semb
US4080472A (en) 1974-03-22 1978-03-21 Societe D'etudes Et D'exploitation De Marques Et Brevets S.E.M.S. Metformin 2-(p-chlorophenoxy)-2-methylpropionate
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US3952741A (en) 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US4034758A (en) 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US4036228A (en) 1975-09-11 1977-07-19 Alza Corporation Osmotic dispenser with gas generating means
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
US4522625A (en) 1982-09-29 1985-06-11 Alza Corporation Drug dispenser comprising wall formed of semipermeable member and enteric member
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US4587117A (en) 1983-06-06 1986-05-06 Alza Corporation Medical device for delivering drug to pH environments greater than 3.5
US4851229A (en) 1983-12-01 1989-07-25 Alza Corporation Composition comprising a therapeutic agent and a modulating agent
US4777049A (en) 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4892739A (en) 1988-04-25 1990-01-09 Ciba-Geigy Corporation Osmotic continuous dispensing oral delivery system containing a pharmaceutically acceptable active agent having a improved core membrane adhesion properties
US5071607A (en) 1990-01-31 1991-12-10 Alza Corporatino Method and apparatus for forming a hole in a drug dispensing device
US5178866A (en) 1990-03-23 1993-01-12 Alza Corporation Dosage form for delivering drug to the intestine
US5178867A (en) 1991-08-19 1993-01-12 Alza Corporation Dosage form for delivering drug in short-time period
DE4432757A1 (en) 1994-09-14 1996-03-21 Boehringer Mannheim Gmbh Pharmaceutical preparation containing metformin and process for its preparation
CN1203846C (en) 1998-03-19 2005-06-01 布里斯托尔-迈尔斯斯奎布公司 Biphasic controlled release delivery system for high solubility pharmaceuticals and method
US6099859A (en) 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
AU768994B2 (en) * 1998-11-12 2004-01-15 Smithkline Beecham Plc Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012097A1 (en) * 1998-08-31 2000-03-09 Andrx Pharmaceuticals, Inc. Controlled release tablet comprising a hypoglycemic drug and an antihyperglycemic drug

Also Published As

Publication number Publication date
EP1335708A1 (en) 2003-08-20
BR0115390A (en) 2004-02-25
AU2002230830A1 (en) 2002-05-15
JP2004531463A (en) 2004-10-14
CA2427195C (en) 2009-10-06
MXPA03003994A (en) 2004-09-10
CA2427195A1 (en) 2002-05-10
NZ525559A (en) 2005-07-29
EP1723948A1 (en) 2006-11-22
KR20030061392A (en) 2003-07-18
WO2002036100A9 (en) 2003-07-24
WO2002036100A1 (en) 2002-05-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030505

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20050601

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ANDRX LABS, LLC

17Q First examination report despatched

Effective date: 20060104

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

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18R Application refused

Effective date: 20121213