EP1307190A4 - Use of il-8 receptor antagonists in the treatment of virus infections - Google Patents

Use of il-8 receptor antagonists in the treatment of virus infections

Info

Publication number
EP1307190A4
EP1307190A4 EP01952777A EP01952777A EP1307190A4 EP 1307190 A4 EP1307190 A4 EP 1307190A4 EP 01952777 A EP01952777 A EP 01952777A EP 01952777 A EP01952777 A EP 01952777A EP 1307190 A4 EP1307190 A4 EP 1307190A4
Authority
EP
European Patent Office
Prior art keywords
treatment
receptor antagonists
virus infections
infections
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01952777A
Other languages
German (de)
French (fr)
Other versions
EP1307190A1 (en
Inventor
Susan B Dillon
Ruth Tal-Singer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1307190A1 publication Critical patent/EP1307190A1/en
Publication of EP1307190A4 publication Critical patent/EP1307190A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP01952777A 2000-07-18 2001-07-16 Use of il-8 receptor antagonists in the treatment of virus infections Withdrawn EP1307190A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21905300P 2000-07-18 2000-07-18
US219053P 2000-07-18
PCT/US2001/022328 WO2002005814A1 (en) 2000-07-18 2001-07-16 Use of il-8 receptor antagonists in the treatment of virus infections

Publications (2)

Publication Number Publication Date
EP1307190A1 EP1307190A1 (en) 2003-05-07
EP1307190A4 true EP1307190A4 (en) 2007-08-22

Family

ID=22817645

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01952777A Withdrawn EP1307190A4 (en) 2000-07-18 2001-07-16 Use of il-8 receptor antagonists in the treatment of virus infections

Country Status (17)

Country Link
EP (1) EP1307190A4 (en)
JP (1) JP2004509852A (en)
KR (1) KR20030019587A (en)
CN (1) CN1449285A (en)
AR (1) AR033830A1 (en)
AU (1) AU2001273497A1 (en)
BR (1) BR0112603A (en)
CA (1) CA2418162A1 (en)
CZ (1) CZ2003132A3 (en)
HU (1) HUP0300754A3 (en)
IL (1) IL153921A0 (en)
MX (1) MXPA03000500A (en)
NO (1) NO20030201L (en)
NZ (1) NZ523659A (en)
PL (1) PL365886A1 (en)
WO (1) WO2002005814A1 (en)
ZA (1) ZA200300474B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008509143A (en) * 2004-08-04 2008-03-27 シェーリング コーポレイション Pharmaceutical formulations containing pleconaril for the treatment of airway diseases
PE20170185A1 (en) * 2014-05-12 2017-04-01 Glaxosmithkline Intellectual Property (No 2) Ltd PHARMACEUTICAL COMPOSITIONS TO TREAT INFECTIOUS DISEASES
BR112022018294A2 (en) * 2020-03-26 2023-01-10 Dompe Farm Spa CXCL8 INHIBITORS FOR USE IN THE TREATMENT OF COVID-19
EP3884932A1 (en) * 2020-03-26 2021-09-29 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitors for use in the treatment of covid-19
EP4008325A1 (en) * 2020-12-02 2022-06-08 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitors for use in the treatment of covid-19

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005836A2 (en) * 1994-08-25 1996-02-29 Medical University Of South Carolina Methods of treating cold symptoms using pentoxifylline
WO2000009511A1 (en) * 1998-08-13 2000-02-24 Astrazeneca Ab Novel thiazolopyrimidine compounds
WO2000012489A1 (en) * 1998-09-01 2000-03-09 Astrazeneca Ab 1, 2, 4-triazole-3-thione compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547979A (en) * 1992-03-30 1996-08-20 Smithkline Beecham TNF inhibition
JPH11503110A (en) * 1995-02-17 1999-03-23 スミスクライン・ビーチャム・コーポレイション IL-8 receptor antagonist

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005836A2 (en) * 1994-08-25 1996-02-29 Medical University Of South Carolina Methods of treating cold symptoms using pentoxifylline
WO2000009511A1 (en) * 1998-08-13 2000-02-24 Astrazeneca Ab Novel thiazolopyrimidine compounds
WO2000012489A1 (en) * 1998-09-01 2000-03-09 Astrazeneca Ab 1, 2, 4-triazole-3-thione compounds

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GRAHAM R: "TAKING ON THE COMMON COLD", TECHNOLOGY REVIEW, ALUMNI ASSOCIATION, CAMBRIDGE, MS, US, February 1997 (1997-02-01), pages 19 - 21, XP002906903, ISSN: 0040-1692 *
HOPKEN ET AL: "467 Increased levels of interleukin-1, interleukin-6, interleukin-8, soluble intercellular adhesion molecule, and bradykinin are detected in nasal secretions of patients during naturally acquired rhinovirus colds", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 97, no. 1, January 1996 (1996-01-01), pages 299, XP005582004, ISSN: 0091-6749 *
See also references of WO0205814A1 *
TERAN LUIS M ET AL: "Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 155, no. 4, 1997, pages 1362 - 1366, XP009086497, ISSN: 1073-449X *
WINTHER B ET AL: "Viral-induced rhinitis.", AMERICAN JOURNAL OF RHINOLOGY 1998 JAN-FEB, vol. 12, no. 1, January 1998 (1998-01-01), pages 17 - 20, XP009086496, ISSN: 1050-6586 *

Also Published As

Publication number Publication date
KR20030019587A (en) 2003-03-06
CZ2003132A3 (en) 2003-09-17
ZA200300474B (en) 2004-08-17
WO2002005814A1 (en) 2002-01-24
AU2001273497A1 (en) 2002-01-30
BR0112603A (en) 2004-08-24
HUP0300754A3 (en) 2009-03-02
PL365886A1 (en) 2005-01-10
NZ523659A (en) 2006-01-27
MXPA03000500A (en) 2003-06-24
JP2004509852A (en) 2004-04-02
NO20030201D0 (en) 2003-01-15
EP1307190A1 (en) 2003-05-07
IL153921A0 (en) 2003-07-31
HUP0300754A2 (en) 2003-08-28
NO20030201L (en) 2003-03-17
CN1449285A (en) 2003-10-15
CA2418162A1 (en) 2002-01-24
AR033830A1 (en) 2004-01-07

Similar Documents

Publication Publication Date Title
EE05507B1 (en) Use of rosuvastatin ZD4522) in the treatment of heterosgococcal family h percolesterolemia
MXPA03004915A (en) Mch antagonists and their use in the treatment of obesity.
HK1056877A1 (en) Mch antagonists and their use in the treatment of obesity.
HUS1300015I1 (en) Antibodies to human il-1beta
DE60124863D1 (en) AGAINST HUMAN INTERLEUKIN-1-BETA RECOMBINANT ANTIBODIES
IL141034A0 (en) Uracil compounds and use thereof
PT1317485E (en) Myostatin antagonists and uses thereof
MXPA03005744A (en) Piperidine mch antagonists and their use in the treatment of obesity.
MXPA03004439A (en) Aminothiazoles and their use as adenosine receptor antagonists.
HUP0301308A3 (en) Human papilloma virus treatment
DE60026949D1 (en) Interconnects
EE200200484A (en) Low dose entecavir preparation and its use
IL152700A0 (en) Substituted 1-aminoalkyl-lactams and their use as muscarinc receptor antagonists
IL153708A0 (en) Benzimidazole derivatives, preparation and therapeutic use thereof
HK1061212A1 (en) Pyranoindazoles and their use for the treatment ofglaucoma
DE60102506D1 (en) Interconnects
HK1074446A1 (en) 3-phenyl substituted pyridoindolone, preparation and therapeutic use thereof
AR027945A1 (en) USE OF PRAMIPEXOL IN THE TREATMENT OF ADDICTION DISORDERS
HUP0401756A3 (en) Substituted benzimidazole compounds and their use
HUP0300599A3 (en) Il-8 receptor antagonists, pharmaceutical compositions containing them and their use
GB0105613D0 (en) Pharmaceutically effective compounds and their use
HUP0300754A3 (en) Use of il-8 receptor antagonists in the treatment of virus infections
DE60100973D1 (en) Interconnects
HUP0300470A3 (en) Il-8 receptor antagonists, pharmaceutical compositions containing them and their use
EP1322319A4 (en) Use of il-8 protein modulators in the treatment of viral infections

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030203

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20070720

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 11/02 20060101ALI20070717BHEP

Ipc: A61K 45/06 20060101ALI20070717BHEP

Ipc: A61K 31/00 20060101AFI20070717BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071018

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1056827

Country of ref document: HK