EP1290230A4 - Hepatitis c virus conjugates - Google Patents

Hepatitis c virus conjugates

Info

Publication number
EP1290230A4
EP1290230A4 EP01939609A EP01939609A EP1290230A4 EP 1290230 A4 EP1290230 A4 EP 1290230A4 EP 01939609 A EP01939609 A EP 01939609A EP 01939609 A EP01939609 A EP 01939609A EP 1290230 A4 EP1290230 A4 EP 1290230A4
Authority
EP
European Patent Office
Prior art keywords
hepatitis
virus conjugates
conjugates
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01939609A
Other languages
German (de)
French (fr)
Other versions
EP1290230A2 (en
Inventor
Anthony J Conley
Philip M Mckenna
Craig T Przysiecki
Paul M Keller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1290230A2 publication Critical patent/EP1290230A2/en
Publication of EP1290230A4 publication Critical patent/EP1290230A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
EP01939609A 2000-06-02 2001-05-29 Hepatitis c virus conjugates Withdrawn EP1290230A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20908900P 2000-06-02 2000-06-02
US209089P 2000-06-02
PCT/US2001/017302 WO2001093804A2 (en) 2000-06-02 2001-05-29 Hepatitis c virus conjugates

Publications (2)

Publication Number Publication Date
EP1290230A2 EP1290230A2 (en) 2003-03-12
EP1290230A4 true EP1290230A4 (en) 2004-10-20

Family

ID=22777281

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01939609A Withdrawn EP1290230A4 (en) 2000-06-02 2001-05-29 Hepatitis c virus conjugates

Country Status (4)

Country Link
EP (1) EP1290230A4 (en)
JP (1) JP2004509846A (en)
CA (1) CA2409287A1 (en)
WO (1) WO2001093804A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2479184A3 (en) * 2003-12-17 2013-09-04 Janssen Alzheimer Immunotherapy Beta immunogenic peptide carrier conjugates and methods of producing the same
WO2005058968A1 (en) * 2003-12-18 2005-06-30 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa A method to make a peptide-carrier conjugate with a high immunogenicity
JP2007531536A (en) * 2004-04-05 2007-11-08 ユニヴェルシテ ボルドー ２ Peptides and peptidomimetics that bind to CD23
EP1885395A4 (en) * 2005-05-16 2009-12-02 Merck & Co Inc A method for improving the immunogenicity of plasmodium antigens

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0467700A2 (en) * 1990-07-19 1992-01-22 Merck & Co. Inc. Coconjugate vaccines comprising immunogenic protein, HIV related peptides, and anionic moieties
US5274122A (en) * 1992-10-15 1993-12-28 Merck & Co., Inc. Acidic derivatives of homocysteine thiolactone
WO1999058561A1 (en) * 1998-05-14 1999-11-18 Pasteur Merieux Serums & Vaccins Hepatitis c virus mimotopes
WO1999060132A1 (en) * 1998-05-19 1999-11-25 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Mimotopes of hypervariable region 1 of the e2 glycoprotein of hcv and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709995A (en) * 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0467700A2 (en) * 1990-07-19 1992-01-22 Merck & Co. Inc. Coconjugate vaccines comprising immunogenic protein, HIV related peptides, and anionic moieties
US5274122A (en) * 1992-10-15 1993-12-28 Merck & Co., Inc. Acidic derivatives of homocysteine thiolactone
WO1999058561A1 (en) * 1998-05-14 1999-11-18 Pasteur Merieux Serums & Vaccins Hepatitis c virus mimotopes
WO1999060132A1 (en) * 1998-05-19 1999-11-25 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Mimotopes of hypervariable region 1 of the e2 glycoprotein of hcv and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Imject Activated SuperCarrier Immune Modulator", PIERCE INSTRUCTIONS, February 1998 (1998-02-01), XP002270167, Retrieved from the Internet <URL:http://www.piercenet.com/files/0137MR-1.PDF> [retrieved on 20040212] *
"Sulfo-SMCC", PIERCE INSTRUCTIONS, - November 2003 (2003-11-01), XP002270168, Retrieved from the Internet <URL:http://www.piercenet.com/files/0581as4.pdf> [retrieved on 20040212] *
GRAS-MASSE H ET AL: "Convergent peptide libraries, or mixotopes, to elicit or to identify specific immune responses", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, vol. 11, no. 2, April 1999 (1999-04-01), pages 223 - 228, XP004257528, ISSN: 0952-7915 *
MEYER KEITH ET AL: "Complement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoprotein", JOURNAL OF VIROLOGY, vol. 76, no. 5, March 2002 (2002-03-01), pages 2150 - 2158, XP002270169, ISSN: 0022-538X *
PUNTORIETO G ET AL: "Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 17, no. 13, 1 July 1998 (1998-07-01), pages 3521 - 3533, XP002111268, ISSN: 0261-4189 *
RUBINSTEIN A ET AL: "Immunologic responses of HIV-1-infected study subjects to immunization with a mixture of peptide protein derivative-V3 loop peptide conjugates.", JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999) UNITED STATES 15 DEC 1999, vol. 22, no. 5, 15 December 1999 (1999-12-15), pages 467 - 476, XP009025773, ISSN: 1525-4135 *

Also Published As

Publication number Publication date
JP2004509846A (en) 2004-04-02
EP1290230A2 (en) 2003-03-12
WO2001093804A3 (en) 2002-05-23
WO2001093804A2 (en) 2001-12-13
CA2409287A1 (en) 2001-12-13

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Legal Events

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Effective date: 20040902

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18D Application deemed to be withdrawn

Effective date: 20051228