EP1283674A4 - Therapy of proliferative disorders by direct irradiation of cell nuclei with tritiated nuclear targeting agents - Google Patents

Therapy of proliferative disorders by direct irradiation of cell nuclei with tritiated nuclear targeting agents

Info

Publication number
EP1283674A4
EP1283674A4 EP01928305A EP01928305A EP1283674A4 EP 1283674 A4 EP1283674 A4 EP 1283674A4 EP 01928305 A EP01928305 A EP 01928305A EP 01928305 A EP01928305 A EP 01928305A EP 1283674 A4 EP1283674 A4 EP 1283674A4
Authority
EP
European Patent Office
Prior art keywords
therapy
proliferative disorders
cell nuclei
targeting agents
direct irradiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01928305A
Other languages
German (de)
French (fr)
Other versions
EP1283674A2 (en
Inventor
Robert A Gatenby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple University of Commonwealth System of Higher Education
Original Assignee
Temple University of Commonwealth System of Higher Education
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple University of Commonwealth System of Higher Education filed Critical Temple University of Commonwealth System of Higher Education
Publication of EP1283674A2 publication Critical patent/EP1283674A2/en
Publication of EP1283674A4 publication Critical patent/EP1283674A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP01928305A 2000-03-24 2001-03-16 Therapy of proliferative disorders by direct irradiation of cell nuclei with tritiated nuclear targeting agents Withdrawn EP1283674A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19215300P 2000-03-24 2000-03-24
US192153P 2000-03-24
US19267100P 2000-03-28 2000-03-28
US192671P 2000-03-28
PCT/US2001/008446 WO2001072203A2 (en) 2000-03-24 2001-03-16 Therapy of proliferative disorders by direct irradiation of cell nuclei with tritiated nuclear targeting agents

Publications (2)

Publication Number Publication Date
EP1283674A2 EP1283674A2 (en) 2003-02-19
EP1283674A4 true EP1283674A4 (en) 2005-04-27

Family

ID=26887786

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01928305A Withdrawn EP1283674A4 (en) 2000-03-24 2001-03-16 Therapy of proliferative disorders by direct irradiation of cell nuclei with tritiated nuclear targeting agents

Country Status (3)

Country Link
EP (1) EP1283674A4 (en)
AU (1) AU2001255179A1 (en)
WO (1) WO2001072203A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR20180126582A (en) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 Steroid hormone pharmaceutical composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0490434A1 (en) * 1990-12-10 1992-06-17 Akzo Nobel N.V. Labelled, modified oligonucleotides
WO1994015646A1 (en) * 1993-01-07 1994-07-21 Thomas Jefferson University Antisense inhibition of c-myc to modulate the proliferation of smooth muscle cells
US5821354A (en) * 1996-11-26 1998-10-13 Angiogene Inc. Radiolabeled DNA oligonucleotide and method of preparation
US5847104A (en) * 1995-05-22 1998-12-08 Hybridon, Inc. Method of tritium labeling oligonucleotide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0490434A1 (en) * 1990-12-10 1992-06-17 Akzo Nobel N.V. Labelled, modified oligonucleotides
WO1994015646A1 (en) * 1993-01-07 1994-07-21 Thomas Jefferson University Antisense inhibition of c-myc to modulate the proliferation of smooth muscle cells
US5847104A (en) * 1995-05-22 1998-12-08 Hybridon, Inc. Method of tritium labeling oligonucleotide
US5821354A (en) * 1996-11-26 1998-10-13 Angiogene Inc. Radiolabeled DNA oligonucleotide and method of preparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
STRAUME T ET AL: "Transmitted proliferation disadvantage from mouse oocytes labeled in vivo with [3H]thymidine: radiosensitive target considerations.", MUTATION RESEARCH. 4 MAR 1997, vol. 374, no. 1, 4 March 1997 (1997-03-04), pages 11 - 19, XP008043131, ISSN: 0027-5107 *
TAN W ET AL: "An efficient synthesis of radioisotopically labeled oligonucleotides through direct solid-phase 5'-phosphitylation", TETRAHEDRON LETTERS 1995 UNITED KINGDOM, vol. 36, no. 30, 1995, pages 5323 - 5326, XP002318770, ISSN: 0040-4039 *
WILEY L M ET AL: "Radiosensitive target in the early mouse embryo exposed to very low doses of ionizing radiation.", MUTATION RESEARCH. 1 AUG 1994, vol. 309, no. 1, 1 August 1994 (1994-08-01), pages 83 - 92, XP008043130, ISSN: 0027-5107 *

Also Published As

Publication number Publication date
AU2001255179A1 (en) 2001-10-08
EP1283674A2 (en) 2003-02-19
WO2001072203A2 (en) 2001-10-04
WO2001072203A3 (en) 2002-10-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20021014

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 51/04 B

Ipc: 7A 01N 43/04 A

A4 Supplementary search report drawn up and despatched

Effective date: 20050311

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20061003